Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Gao
Avascular necrosis frequently occurs as a complication following surgery involving the distal perforator flap. Dihydrocapsaicin (DHC) can protect tissue from ischemia-reperfusion (I/R) injury, but its specific role in multizone perforator flaps remains unclear. In this study, the prospective target of DHC in the context of I/R injury was predicted using network pharmacology analysis. Flap viability was determined through survival area analysis, laser Doppler blood flow, angiograms, and histological examination...
March 8, 2024: Phytotherapy Research: PTR