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https://www.readbyqxmd.com/read/28526023/high-incidence-of-periprosthetic-joint-infection-with-propionibacterium-acnes-after-the-use-of-a-stemless-shoulder-prosthesis-with-metaphyseal-screw-fixation-a-retrospective-cohort-study-of-241-patients-propionibacter-infections-after-eclipse-tsa
#1
Lisa Johansson, Nils P Hailer, Hans Rahme
BACKGROUND: A stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (Eclipse®). The aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. METHODS: Two hundred and forty-one patients (54.8% females) were operated with a shoulder arthroplasty and followed for median 2.0 (0...
May 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28516404/screening-for-diabetic-eye-disease-among-samoan-adults-a-pilot-study
#2
V Swetha E Jeganathan, Tim Langford, Lucilla Ah-Ching Sefo, Alex W Hewitt, Nitin Verma
INTRODUCTION: The purpose of this study was to determine the prevalence of diabetic retinopathy in Samoa by piloting a retinal photography screening programme. METHODS: We performed a cross-sectional study of patients with diabetes who presented to the Tupua Tamasese Meaole eye clinic in Apia, Samoa, between May 2011 and September 2011. Study approval was granted by the National Health Service Board of Samoa, the Monash University Human Research Ethics Committee, and the study adhered to the Tenets of the Declaration of Helsinki...
May 17, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28490557/the-effect-of-empagliflozin-on-oxidative-nucleic-acid-modifications-in-patients-with-type-2-diabetes-protocol-for-a-randomised-double-blinded-placebo-controlled-trial
#3
Emil List Larsen, Vanja Cejvanovic, Laura Kofoed Kjær, Tina Vilsbøll, Filip Krag Knop, Jørgen Rungby, Henrik Enghusen Poulsen
INTRODUCTION: Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). Although glycaemic control reduces microvascular complications, the effect of intensive treatment strategies or individual drugs on macrovascular diseases is still debated. RNA oxidation is associated with increased mortality in patients with T2D. Inspired by animal studies showing effect of a sodium-glucose cotransporter-2 (SGLT-2) inhibitor (empagliflozin) on oxidative stress and a recent trial evaluating empagliflozin that demonstrated improved cardiovascular outcomes in patients with T2D at high risk of cardiovascular events, we hypothesise that empagliflozin lowers oxidative stress...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28464405/issue-information-declaration-of-helsinki
#4
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28446182/improving-preimplantation-genetic-diagnosis-pgd-reliability-by-selection-of-sperm-donor-with-the-most-informative-haplotype
#5
Mira Malcov, Veronica Gold, Sagit Peleg, Tsvia Frumkin, Foad Azem, Ami Amit, Dalit Ben-Yosef, Yuval Yaron, Adi Reches, Shimi Barda, Sandra E Kleiman, Leah Yogev, Ron Hauser
BACKGROUND: The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier's one. METHODS: A panel of 4-9 informative polymorphic markers, flanking the mutation in carriers of autosomal dominant/X-linked disorders, was tested in DNA of sperm donors before PGD. Whenever the lengths of donors' repeats overlapped those of the women, additional donors' DNA samples were analyzed...
April 26, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28437155/eyelid-reconstruction-using-the-hughes-tarsoconjunctival-advancement-flap-long-term-outcomes-in-122-consecutive-cases-over-a-13-year-period
#6
James McKelvie, Reid Ferguson, Stephen G J Ng
This article evaluates the complications and long term functional and cosmetic outcomes of tarsoconjunctival advancement flaps for repairing a range of lower eyelid defects in a large cohort of consecutive cases. A retrospective series of 122 consecutive cases of eyelid reconstruction using tarsoconjunctival-advancement flaps was conducted at Waikato Hospital, or Hamilton Eye Clinic, New Zealand. All cases of lid reconstruction using tarsoconjunctival-advancement flaps between January 1, 2001 until April 3, 2014 were included for analysis...
April 24, 2017: Orbit
https://www.readbyqxmd.com/read/28418621/issue-information-declaration-of-helsinki
#7
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28348182/constraint-choice-in-revision-knee-arthroplasty-study-protocol-of-a-randomised-controlled-trial-assessing-the-effect-of-level-of-constraint-on-postoperative-outcome
#8
Hagen Hommel, Kai Wilke, Daniel Kunze, Peggy Hommel, Peter Fennema
INTRODUCTION: The proper management of total knee arthroplasty (TKA) in patients with severe deformities regarding the preferable prosthetic design and the required amount of constraint is a controversial subject. In the absence of any high-level clinical evidence, we designed a randomised clinical trial to investigate if rotating hinged (RTH) and constrained condylar knee (CCK) designs yield similar outcomes. METHODS AND ANALYSIS: This study is a multicentre, randomised clinical trial including two groups of 85 patients...
March 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28331367/knowledge-attitudes-and-behaviors-of-primary-health-care-nurses-and-midwives-in-breast-cancer-early-diagnosis-applications
#9
Aliye Bulut, Aziz Bulut
PURPOSE: The purpose of this research was to analyze the knowledge, attitudes and behaviors of the nurses and midwives about the early diagnosis of breast cancer. MATERIALS AND METHODS: This cross-sectional study was carried out at 9 family medical centers (FMCs) and 1 community health center (CHC) in Bingol; the population of this research consisted of 25 midwives and 38 nurses. The protocol for this study was approved by the regional ethics committee of Bingol University...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28290964/anabolic-adaptations-occur-in-conscripts-during-basic-military-training-despite-high-prevalence-of-vitamin-d-deficiency-and-decrease-in-iron-status
#10
Vahur Ööpik, Saima Timpmann, Leho Rips, Indrek Olveti, Kersti Kõiv, Martin Mooses, Hanno Mölder, Ahti Varblane, Hele-Reet Lille, Helena Gapeyeva
INTRODUCTION: In Estonian Defense Forces that are drawn up on the basis of the conscription model considerable numbers of young men are prematurely discharged from military service for medical reasons, but causes leading to premature dropout of conscripts have not been systematically studied. However, one of the factors involved could be relatively demanding physical training that starts at the beginning of military service in the form of basic military training (BMT). Cumulative training and nontraining stresses experienced by conscripts during BMT may exceed their physiological adaptability and increase the probability of becoming prematurely discharged...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28281157/climate-change-and-professional-responsibility-a-declaration-of-helsinki-for-engineers
#11
Rob Lawlor, Helen Morley
In this paper, we argue that the professional engineering institutions ought to develop a Declaration of Climate Action. Climate change is a serious global problem, and the majority of greenhouse gas emissions come from industries that are enabled by engineers and represented by the engineering professional institutions. If the professional institutions take seriously the claim that a profession should be self-regulating, with codes of ethics that go beyond mere obedience to the law, and if they take their own ethical codes seriously, recognising their responsibility to the public and to future generations (and also recognising a duty of "responsible leadership"), the professional institutions ought to develop a declaration for engineers, addressing climate change...
March 9, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28280304/factors-associated-with-preoperative-anxiety-levels-of-turkish-surgical-patients-from-a-single-center-in-ankara
#12
Ezgi Erkilic, Elvin Kesimci, Cem Soykut, Cihan Doger, Tülin Gumus, Orhan Kanbak
BACKGROUND: Preoperative anxiety and stress are undoubtedly a difficult experience in patients undergoing elective surgery. These unpleasant sensations depend on several factors. The objective of this study was to evaluate the preoperative anxiety levels in a sample of Turkish population, as well as the underlying causes using the Spielberger State-Trait Anxiety Inventory (STAI anxiety) scale. METHODS: The study was conducted according to the Declaration of Helsinki and was approved by the local ethical committee...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28266774/issue-information-declaration-of-helsinki
#13
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28260450/questionnaire-on-brain-death-and-organ-procurement
#14
Saleh Hammad, Manal Alnammourah, Farah Almahmoud, Mais Fawzi, Abdel-Hadi Breizat
OBJECTIVES: The subject of organs for transplant after brain death raises many concerns, including definition and timing of death, how to permit human organ transplant, and the idea of paying for organs. Many ethical concerns are raised regarding regulations and procedures for organ transplant in developing countries. These include where and how to obtain organs and the concept of justice in organ distribution. MATERIALS AND METHODS: We administered 2682 questionnaires to 628 men and 2054 women over 24 months (range, 18 to 70 years old)...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260347/adhd-and-enuresis-a-study-about-effectiveness-of-treatment-with-methylphenidate-or-desmopressin-in-a-pediatric-population
#15
Pietro Ferrara, Valeria Sannicandro, Francesca Ianniello, Enrica Quattrocchi, Annamaria Sbordone, Tommasangelo Petitti, Paolo Mariotti
BACKGROUND: To evaluate the effectiveness of treatment with methylphenidate or desmopressin (dDAVP) in patients with comorbid ADHD and enuresis. METHODS: We enrolled 103 patients affected by ADHD and 125 patients with monosymptomatic nocturnal enuresis (NE). Data were collected between January 2014 and December 2015. The study was carried out in compliance with the Helsinki Declaration. RESULTS: About children with ADHD, 9/103 (8,7%) were also suffering from NE; of those 8/9 followed treatment with methylphenidate and cognitive behavioral therapy...
March 3, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28245293/protective-effect-of-1%C3%AE-25-dihydroxyvitamin-d3-on-effector-cd4-t-cell-induced-injury-in-human-renal-proximal-tubular-epithelial-cells
#16
Byung Ha Chung, Bo-Mi Kim, Kyoung Chan Doh, Mi-La Cho, Kyoung Woon Kim, Chul Woo Yang
BACKGROUND: The aim of this study was to investigate the protective effect of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] on effector CD4+ T cells or on inflammatory cytokine-induced injury in human renal proximal tubular epithelial cells (HRPTEpiC). METHODS: First, we investigated the effect of 1,25(OH)2D3 on CD4+ T cell proliferation. Second, we examined the effect of 1,25(OH)2D3 on inflammatory cytokine secretion or fibrosis in HRPTEpiC induced by inflammatory cytokines or activated CD4+ T cells using ELISA and real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28219961/protocol-for-the-development-of-a-core-domain-set-for-hidradenitis-suppurativa-trial-outcomes
#17
Linnea Thorlacius, John R Ingram, Amit Garg, Bente Villumsen, Solveig Esmann, Joslyn S Kirby, Alice B Gottlieb, Joseph F Merola, Robert Dellavalle, Robin Christensen, Gregor B E Jemec
INTRODUCTION: Randomised controlled trials (RCTs) should have well-defined primary and secondary outcomes to answer questions generated by the main hypotheses. However, for the chronic, inflammatory skin disease hidradenitis suppurativa (HS), the reported outcome measures are numerous and diverse. A recent systematic review found a total of 30 outcome measure instruments in 12 RCTs. This use of a broad range of outcome measures can increase difficulties in interpretation and comparison of results and may potentially obstruct appropriate evidence synthesis by causing reporting bias...
February 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28214788/authorship-criteria-and-reporting-of-ethical-compliance-in-indian-biomedical-journals
#18
Pravin Bolshete
The "instructions to authors" of a total of 55 PubMed/MEDLINE indexed Indian biomedical journals were evaluated to assess the authorship criteria and guidance on reporting of research ethics including incorporation of recent updates. Thirty-seven (67.3%) journals recommended the ICMJE guidelines for manuscript preparation. Thirty-two of 55 (58.2%) journals defined authorship; only two journals defined authorship as per the latest (2013) ICMJE criteria. The journals' recommendations which indicated ethical compliance in articles were - the conduct of a study in accordance with the Declaration of Helsinki(n=39); ethical approval (n=37); consent (n=26); assent (n=10); and consent for identifiable information (n=31)...
February 1, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28160317/issue-information-declaration-of-helsinki
#19
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28132008/compensatory-changes-in-energy-balance-during-dapagliflozin-treatment-in-type-2-diabetes-mellitus-a-randomised-double-blind-placebo-controlled-cross-over-trial-energize-study-protocol
#20
Surya Panicker Rajeev, Victoria S Sprung, Carl Roberts, Jo A Harrold, Jason C G Halford, Andrej Stancak, Emma J Boyland, Graham J Kemp, Daniel J Cuthbertson, John P H Wilding
INTRODUCTION: Sodium glucose cotransporter 2 (SGLT2) inhibitors are effective blood-glucose-lowering medications with beneficial effects on body weight in patients with type 2 diabetes mellitus (T2DM). However, observed weight loss is less than that predicted from quantified glycosuria, suggesting a compensatory increase in energy intake or a decrease in energy expenditure. Studies using dual-energy X-ray absorptiometry (DEXA) have suggested most body weight change is due to loss of adipose tissue, but organ-specific changes in fat content (eg, liver, skeletal muscle) have not been determined...
January 27, 2017: BMJ Open
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