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https://www.readbyqxmd.com/read/28627956/evaluating-the-effects-of-botulinum-toxin-a-on-tear-metrics-in-patients-with-hemifacial-spasm
#1
Yasmin Poustchi Mali, Robert L Schultze, Edward J Wladis
Hemifacial spasm has been previously shown to result in dry eye and ocular surface diseases. This study was performed to assess the impact of chemodenervation with botulinum toxin on clinically-relevant metrics of tears. Tear osmolarity and lipid layer thickness were measured in patients with hemifacial spasm after they achieved relief from hemifacial spasm via botulinum toxin injections. Twelve eyes of 6 patients with hemifacial spasm (2 men and 4 women; mean age 55.5 years) were assessed in accordance with the Declaration of Helsinki and IRB approval...
June 19, 2017: Orbit
https://www.readbyqxmd.com/read/28627813/effect-of-the-oxidant-antioxidant-system-in-seminal-plasma-on-varicocele-and-idiopathic-infertility-in-male-humans
#2
Hayrullah Yazar, Fikret Halis, Yasemin Nasir, Derya Guzel, Mehmet Akdogan, Ahmet Gokce
BACKGROUND: The aim of this study was to investigate seminal oxidant-antioxidant activity in idiopathic and varicocele infertility in men. METHODS: Total anti-oxidant capacity (TAC), total oxidant status (TOS), paraoxonase (PON1), aryl esterase (ARE), and total thiol levels (TTL) were measured in seminal plasma with an autoanalyzer. The TOS/TAC ratio was determined as the oxidative stress index (OSI). A histopathological evaluation of the sperm was performed in the andrology laboratory of the hospital...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28625821/the-use-of-study-registration-and-protocols-in-plastic-surgery-research-a-systematic-review
#3
REVIEW
Thomas Edward Pidgeon, Christopher Limb, Riaz A Agha, Katharine Whitehurst, Charmilie Chandrakumar, Georgina Wellstead, Alexander J Fowler, Dennis P Orgill
BACKGROUND: In 2013, the Declaration of Helsinki changed to mandate that all research studies involving human subjects must have a protocol registered in a publicly accessible database prior to the enrolment of the first patient, rather than just clinical trials. The objective of this work was to assess the number of research studies involving human participants published in leading journals of plastic surgery that had either published or registered a protocol with a publicly accessible database...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28616041/efficacy-of-intraorbital-electroacupuncture-for-diabetic-abducens-nerve-palsy-study-protocol-for-a-prospective-single-center-randomized-controlled-trial
#4
Ling-Yun Zhou, Xue-Mei Li, Tie-Juan Liu, Xiao-Jie Ji, Ming Zhao, Chang Su, Ji-Chao Liu, Jiang-Yun Sun
Abducens nerve palsy (ANP) is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28614151/success-rate-of-variable-collar-size-frosted-jones-tubes
#5
C Blake Perry, Roger A Dailey
PURPOSE: To describe success rates and long-term outcomes of conjunctivodacryocystorhinostomy (CDCR) with larger collar (4.5 or 5.0 mm) frosted Jones tubes (FJTs). METHODS: A retrospective chart review of all patients who received a larger collar (4.5 or 5.0 mm) FJT following CDCR by an author (RAD) was performed between January 1, 2010 and July 1, 2016. Patient demographics, etiology of tearing, follow-up time from placement of larger collar FJT, original tube collar diameter, number and sizes of collar adjustments, tearing status, and complications were recorded...
June 13, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28604315/exploitation-of-the-vulnerable-in-research-responses-to-lessons-learnt-in-history
#6
Amaboo Dhai
The Nuremberg Trials raised insightful issues on how and why doctors who were trained in the Hippocratic tradition were able to commit such egregious and heinous medical crimes. The vulnerable were considered to be subhuman, of decreased intelligence, of no moral status and lacking human dignity. The reputation of the medical profession had been undermined, professionalism questioned and the doctor-patient relationship damaged as a result of the Nazi medical experiments. The World Medical Association's Declaration of Helsinki has been hailed as one of the most successful efforts in rescuing medical research from the darkness of the scandals and tragedies in health research...
May 24, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28601920/human-dignity-as-a-basis-for-providing-post-trial-access-to-healthcare-for-research-participants-a-south-african-perspective
#7
Pamela Andanda, Jane Wathuta
This paper discusses the need to focus on the dignity of human participants as a legal and ethical basis for providing post-trial access to healthcare. Debate about post-trial benefits has mostly focused on access to products or interventions proven to be effective in clinical trials. However, such access may be modelled on a broad fair benefits framework that emphasises both collateral benefits and interventional products of research, instead of prescribed post-trial access alone (Legal and ethical regulation of biomedical research in developing countries p...
June 10, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28599351/issue-information-declaration-of-helsinki
#8
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28592573/protocol-for-a-randomised-controlled-trial-of-the-effect-of-dapagliflozin-metformin-and-exercise-on-glycaemic-variability-body-composition-and-cardiovascular-risk-in-prediabetes-the-pre-d-trial
#9
Kristine Færch, Hanan Amadid, Lea Bruhn Nielsen, Mathias Ried-Larsen, Kristian Karstoft, Frederik Persson, Marit Eika Jørgensen
INTRODUCTION: The primary aim of this study is to compare the efficacy of three short-term glucose-lowering interventions (exercise, metformin and dapagliflozin) on glycaemic variability in overweight or obese men and women with elevated diabetes risk (ie, prediabetes, defined as haemoglobin A1c (HbA1c)39-47 mmol/mol / 5.7%-6.4%). The secondary aims are to investigate the effects of the interventions on body composition and cardiometabolic risk factors. METHODS AND ANALYSIS: The Pre-D Trial is an investigator-initiated, randomised, controlled, parallel, open-label, superiority trial...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28576892/study-protocol-of-a-pragmatic-randomised-controlled-pilot-trial-clinical-effectiveness-on-smoking-cessation-of-traditional-and-complementary-medicine-interventions-including-acupuncture-and-aromatherapy-in-combination-with-nicotine-replacement-therapy
#10
Soobin Jang, Sunju Park, Bo-Hyoung Jang, Yu Lee Park, Ju Ah Lee, Chung-Sik Cho, Ho-Yeon Go, Yong Cheol Shin, Seong-Gyu Ko
INTRODUCTION: Nicotine dependence is a disease, and tobacco use is related to 6 million deaths annually worldwide. Recently, in many countries, there has been growing interest in the use of traditional and complementary medicine (T&CM) methods, especially acupuncture, as therapeutic interventions for smoking cessation. The aim of this pilot study is to investigate the effectiveness of T&CM interventions on smoking cessation. METHODS AND ANALYSIS: The STOP (Stop Tobacco Programme using traditional Korean medicine) study is designed to be a pragmatic, open-label, randomised pilot trial...
June 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28562097/a-simple-point-of-care-test-can-indicate-the-need-for-periodontal-therapy-to-reduce-the-risk-for-adverse-pregnancy-outcomes-in-mothers-attending-antenatal-clinics
#11
Mervyn Sydney Turton, Ralf Reinhold Henkel, Charlene Wilma Joyce Africa
INTRODUCTION: Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for PD, may inform obstetricians and other antenatal healthcare practitioners, of the risk of adverse pregnancy outcomes in mothers attending antenatal clinics. METHODS: At first visit, the presence of suspected periodontopathogens was assessed by BANA testing of dental plaque from 443 mothers attending antenatal clinics in KwaZulu-Natal, South Africa and an association later sought with pregnancy outcomes...
June 6, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28558720/associations-between-transition-to-retirement-and-changes-in-dietary-intakes-in-french-adults-nutrinet-sant%C3%A3-cohort-study
#12
Wendy Si Hassen, Katia Castetbon, Eva Lelièvre, Aurélie Lampuré, Serge Hercberg, Caroline Méjean
BACKGROUND: Few studies have focused on the influence of retirement on dietary behaviors. Our study aimed at assessing the associations between transition to retirement and changes in dietary intake in French adults, particularly according to spousal retirement and baseline income. METHODS: This prospective study included 577 French participants from the NutriNet-Santé cohort who retired over a 5-year follow-up (2009-2014 or 2010-2015). At baseline and every year, dietary intakes were assessed using 24 h records...
May 30, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28550022/longitudinal-assessment-of-brain-derived-neurotrophic-factor-in-sardinian-psychotic-patients-labsp-a-protocol-for-a-prospective-observational-study
#13
Diego Primavera, Mirko Manchia, Luca Deriu, Massimo Tusconi, Roberto Collu, Maria Scherma, Paola Fadda, Walter Fratta, Bernardo Carpiniello
INTRODUCTION: Brain-derived neurotrophic factor (BDNF) plays a crucial role in neurodevelopment, synaptic plasticity and neuronal function and survival. Serum and plasma BDNF levels are moderately, but consistently, decreased in patients with schizophrenia (SCZ) compared with healthy controls. There is a lack of knowledge, however, on the temporal manifestation of this decline. Clinical, illness course and treatment factors might influence the variation of BDNF serum levels in patients with psychosis...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28526023/high-incidence-of-periprosthetic-joint-infection-with-propionibacterium-acnes-after-the-use-of-a-stemless-shoulder-prosthesis-with-metaphyseal-screw-fixation-a-retrospective-cohort-study-of-241-patients-propionibacter-infections-after-eclipse-tsa
#14
Lisa Johansson, Nils P Hailer, Hans Rahme
BACKGROUND: A stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (Eclipse®). The aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. METHODS: Two hundred and forty-one patients (54.8% females) were operated with a shoulder arthroplasty and followed for median 2.0 (0...
May 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28516404/screening-for-diabetic-eye-disease-among-samoan-adults-a-pilot-study
#15
V Swetha E Jeganathan, Tim Langford, Lucilla Ah-Ching Sefo, Alex W Hewitt, Nitin Verma
INTRODUCTION: The purpose of this study was to determine the prevalence of diabetic retinopathy in Samoa by piloting a retinal photography screening programme. METHODS: We performed a cross-sectional study of patients with diabetes who presented to the Tupua Tamasese Meaole eye clinic in Apia, Samoa, between May 2011 and September 2011. Study approval was granted by the National Health Service Board of Samoa, the Monash University Human Research Ethics Committee, and the study adhered to the Tenets of the Declaration of Helsinki...
June 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28490557/the-effect-of-empagliflozin-on-oxidative-nucleic-acid-modifications-in-patients-with-type-2-diabetes-protocol-for-a-randomised-double-blinded-placebo-controlled-trial
#16
Emil List Larsen, Vanja Cejvanovic, Laura Kofoed Kjær, Tina Vilsbøll, Filip Krag Knop, Jørgen Rungby, Henrik Enghusen Poulsen
INTRODUCTION: Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). Although glycaemic control reduces microvascular complications, the effect of intensive treatment strategies or individual drugs on macrovascular diseases is still debated. RNA oxidation is associated with increased mortality in patients with T2D. Inspired by animal studies showing effect of a sodium-glucose cotransporter-2 (SGLT-2) inhibitor (empagliflozin) on oxidative stress and a recent trial evaluating empagliflozin that demonstrated improved cardiovascular outcomes in patients with T2D at high risk of cardiovascular events, we hypothesise that empagliflozin lowers oxidative stress...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28464405/issue-information-declaration-of-helsinki
#17
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28446182/improving-preimplantation-genetic-diagnosis-pgd-reliability-by-selection-of-sperm-donor-with-the-most-informative-haplotype
#18
Mira Malcov, Veronica Gold, Sagit Peleg, Tsvia Frumkin, Foad Azem, Ami Amit, Dalit Ben-Yosef, Yuval Yaron, Adi Reches, Shimi Barda, Sandra E Kleiman, Leah Yogev, Ron Hauser
BACKGROUND: The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier's one. METHODS: A panel of 4-9 informative polymorphic markers, flanking the mutation in carriers of autosomal dominant/X-linked disorders, was tested in DNA of sperm donors before PGD. Whenever the lengths of donors' repeats overlapped those of the women, additional donors' DNA samples were analyzed...
April 26, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28437155/eyelid-reconstruction-using-the-hughes-tarsoconjunctival-advancement-flap-long-term-outcomes-in-122-consecutive-cases-over-a-13-year-period
#19
James McKelvie, Reid Ferguson, Stephen G J Ng
This article evaluates the complications and long term functional and cosmetic outcomes of tarsoconjunctival advancement flaps for repairing a range of lower eyelid defects in a large cohort of consecutive cases. A retrospective series of 122 consecutive cases of eyelid reconstruction using tarsoconjunctival-advancement flaps was conducted at Waikato Hospital, or Hamilton Eye Clinic, New Zealand. All cases of lid reconstruction using tarsoconjunctival-advancement flaps between January 1, 2001 until April 3, 2014 were included for analysis...
April 24, 2017: Orbit
https://www.readbyqxmd.com/read/28418621/issue-information-declaration-of-helsinki
#20
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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