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https://www.readbyqxmd.com/read/29678987/protocol-for-a-phase-iii-non-inferiority-randomised-comparison-of-a-new-fibrinogen-concentrate-versus-cryoprecipitate-for-treating-acquired-hypofibrinogenaemia-in-bleeding-cardiac-surgical-patients-the-fibres-trial
#1
Keyvan Karkouti, Jeannie Callum, Vivek Rao, Nancy Heddle, Michael E Farkouh, Mark A Crowther, Damon C Scales
INTRODUCTION: Coagulopathic bleeding is a serious complication of cardiac surgery to which an important contributor is acquired hypofibrinogenaemia (plasma fibrinogen <1.5-2.0 g/L). The standard intervention for acquired hypofibrinogenaemia is cryoprecipitate, but purified fibrinogen concentrates are also available. There is little comparative data between the two therapies and randomised trials are needed. METHODS AND ANALYSIS: FIBrinogen REplenishment in Surgery (FIBRES) is a multicentre, randomised (1:1), active-control, single-blinded, phase III trial in adult cardiac surgical patients experiencing clinically significant bleeding related to acquired hypofibrinogenaemia...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29672208/evisceration-with-autogenous-scleral-graft-and-bioceramic-implantation-within-the-modified-scleral-shell-133-cases-over-17-years
#2
Jeremy Nadal, Vincent Daien, Jérôme Jacques, Didier Hoa, Frederic Mura, Max Villain
INTRODUCTION: To present long-term follow-up data on evisceration performed with autogenous scleral grafting and ceramic implantation in a modified scleral shell. METHODS: This was a retrospective analysis of all consecutive eviscerations performed in the Department of Ophthalmology, Montpellier University Hospital, France, between February 1998 and October 2015. For all patients, the technique used was a conventional anterior evisceration after total keratectomy, disinsertion of the medial rectus muscle, sectioning of the optic nerve and excision of sclera centered on the papilla...
April 19, 2018: Orbit
https://www.readbyqxmd.com/read/29643159/role-of-iodine-containing-multivitamins-during-pregnancy-for-children-s-brain-function-protocol-of-an-ongoing-randomised-controlled-trial-the-swiddich-study
#3
Sofia Manousou, Birgitta Johansson, Anna Chmielewska, Janna Eriksson, Kerstin Gutefeldt, Carl-Johan Tornhage, Robert Eggertsen, Helge Malmgren, Lena Hulthen, Magnus Domellöf, Helena Nystrom Filipsson
INTRODUCTION: Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. The aim of the Swedish Iodine in Pregnancy and Development in Children study is to determine the effect of daily supplementation with 150 µg iodine during pregnancy on the offspring's neuropsychological development up to 14 years of age...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29609818/reference-3-t-mri-parameters-of-the-normal-human-eye
#4
Laura Fanea
The purpose of this study is to establish magnetic resonance imaging (MRI) standard normative reference quantitative markers for future possible diagnosis in Ophthalmology based on relaxation times (T1 and T2) and retina/choroid complex (RCC) layer thickness values measured in vivo in normal human eyes. This research followed the tenets of the Declaration of Helsinki and was approved by the local Ethical Committee. 15 healthy subjects volunteered to undergo MRI of both eyes. 3 T MRI was performed using a circular surface detector coil with a 15 min acquisition protocol for each eye...
March 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29602860/protocol-for-the-trismus-trial-therabite-versus-wooden-spatula-in-the-amelioration-of-trismus-in-patients-with-head-and-neck-cancer-randomised-pilot-study
#5
Rana Lee, Alex Molassiotis, Simon N Rogers, Rhiannon Tudor Edwards, David Ryder, Nick Slevin
INTRODUCTION: Patients can develop trismus from their head and neck cancer or as a result of treatment. Trismus affects the jaw muscles and makes mouth opening difficult. To potentially combat trismus, patients could undertake proactive jaw stretching exercises prior to, during and after radiotherapy, although currently these are not the standard of care. METHODS AND ANALYSIS: This is a randomised, open-label, controlled, two-centre feasibility study, to assess the objective and subjective effectiveness and cost-effectiveness of therabite use compared with wooden spatula in ameliorating trismus in patients treated for stage 3 and 4 oral and oropharyngeal cancer, managed either by primary surgery followed by (chemo)radiotherapy or primary (chemo)radiotherapy...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29602847/protocol-for-the-mixed-methods-process-and-context-evaluation-of-the-tb-tobacco-randomised-controlled-trial-in-bangladesh-and-pakistan-a-hybrid-effectiveness-implementation-study
#6
Melanie Boeckmann, Iveta Nohavova, Omara Dogar, Eva Kralikova, Alexandra Pankova, Kamila Zvolska, Rumana Huque, Razia Fatima, Maryam Noor, Helen Elsey, Aziz Sheikh, Kamran Siddiqi, Daniel Kotz
INTRODUCTION: Tuberculosis (TB) remains a significant public health problem in South Asia. Tobacco use increases the risks of TB infection and TB progression. The TB& Tobacco placebo-controlled randomised trial aims to (1) assess the effectiveness of the tobacco cessation medication cytisine versus placebo when combined with behavioural support and (2) implement tobacco cessation medication and behavioural support as part of general TB care in Bangladesh and Pakistan. This paper summarises the process and context evaluation protocol embedded in the effectiveness-implementation hybrid design...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29590325/real-time-monitoring-using-a-breathalyzer-based-ehealth-system-can-identify-lapse-relapse-patterns-in-alcohol-use-disorder-patients
#7
Markku D Hämäläinen, Andreas Zetterström, Maria Winkvist, Marcus Söderquist, Elin Karlberg, Patrik Öhagen, Karl Andersson, Fred Nyberg
Aim: We introduce a new remote real-time breathalyzer-based method for monitoring and early identification of lapse/relapse patterns for alcohol use disorder (AUD) patients using a composite measure of sobriety, the Addiction Monitoring Index (AMI). Methods: We constructed AMI from (a) obtained test results and (b) the pattern of ignored tests using data from the first 30 patients starting in the treatment arms of two on-going clinical trials. The patients performed 2-4 scheduled breath alcohol content (BrAC)-tests per day presented as blood alcohol content (BAC) data...
March 24, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29580756/case-series-of-ocular-involvement-due-to-dengue-first-reported-cases-in-guatemala
#8
M A Carrillo-Soto
OBJECTIVE: Describe the ocular findings of a case series of 8 patients with a diagnosis of dengue. MATERIALS AND METHODS: Review of clinical records and interviews with patients during outpatient visits, after informed consent was obtained and following the ethical standards of the Helsinki declaration. The patients were diagnosed with diagnosis by IgM / IgG dengue serology in whom ocular involvement was identified, between January and October 2017 in Retinal-vascular clinic of the "Dr...
March 23, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29553442/factors-affecting-adherence-to-appointment-system-in-the-clinic-for-non-communicable-diseases-in-unrwa-s-khan-younis-health-centre-and-the-role-of-mobile-phone-text-messages-to-improve-adherence-a-descriptive-cross-sectional-study
#9
Sanaa Al Najjar, Tamer Al Shaer
BACKGROUND: To meet the emerging needs of the increasing numbers of patients with non-communicable diseases and to provide optimum care with optimum contact time and minimum waiting time, as stated in UNRWA guidelines, the mobile phone text messaging system was implemented in UNRWA centres to remind patients of upcoming appointments and to thereby improve the quality of care for vulnerable patients and regulate the work load in the clinics for non-communicable diseases. The aim of this study was to assess the causes for lack of adherence to the appointment system at UNRWA centres...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29544552/socio-economic-and-demographic-factors-associated-with-snacking-behavior-in-a-large-sample-of-french-adults
#10
Wendy Si Hassen, Katia Castetbon, Sandrine Péneau, Christine Tichit, Anouar Nechba, Aurélie Lampuré, France Bellisle, Serge Hercberg, Caroline Méjean
BACKGROUND: Few studies have specifically focused on demographic and socio-economic characteristics associated with snacking in adults, whereas their identification could be useful for defining effective public health measures. The aim of our study was to assess the associations of these factors with daily snacking behavior and its dietary quality. METHODS: This cross-sectional study included 84,692 women and 23,491 men from the NutriNet-Santé cohort study. Occurrence of snacking, energy intake from snacks, snack nutrient, and energy densities were assessed using 24-h dietary records of weekdays at baseline...
March 15, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29544543/ethical-principles-and-placebo-controlled-trials-interpretation-and-implementation-of-the-declaration-of-helsinki-s-placebo-paragraph-in-medical-research
#11
Antonia-Sophie Skierka, Karin B Michels
BACKGROUND: In October 2013, the Declaration of Helsinki was revised a seventh time in its 50 year history. While it is the most widely accepted set of ethical principles for the protection of patients participating in medical research, the Declaration of Helsinki has also been subject of constant controversy. In particular, its paragraph on the use of placebo controls in clinical trials divides the research community into active-control and placebo orthodox proponents, both continuously demanding revisions of the Declaration of Helsinki in favour of their position...
March 15, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29523569/a-tailored-strategy-for-designing-the-walk-copenhagen-walk-cph-intervention-to-increase-mobility-in-hospitalised-older-medical-patients-a-protocol-for-the-qualitative-part-of-the-walk-cph-project
#12
Jeanette Wassar Kirk, Ann Christine Bodilsen, Tine Tjørnhøj-Thomsen, Mette Merete Pedersen, Thomas Bandholm, Rasmus Skov Husted, Lise Kronborg Poulsen, Janne Petersen, Ove Andersen, Per Nilsen
INTRODUCTION: Older medical patients (>65 years) represent 54% of the admissions to Danish medical and emergency departments. Acute admissions and bed-rest during hospitalisation are independent risk factors for death and dependency in older patients. Even short hospitalisations are associated with increased dependency in activities of daily living after discharge. Interventions that increase mobility during hospitalisation are therefore important. The purpose of this protocol is to describe the intervention design of the WALK-Copenhagen project, aimed at increasing 24 hours mobility in older medical patients during acute hospitalisations and following discharge...
March 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29522919/brief-report-preliminary-study-on-evaluation-of-spasticity-in-patients-with-brain-lesions-using-mechanomyography
#13
Sang Woo Jun, Suk Joong Yong, Min Jo, Young Ho Kim, Sung Hoon Kim
BACKGROUND: Electromyography and the modified Ashworth scale (MAS) are among the most effective methods for evaluating spasticity; however, these are often inappropriate for clinical use, owing to the complicated procedure and subjective evaluation outcomes. METHODS: A passive stretch reflex test was performed on 10 subjects with brain lesions. Furthermore, mechanomyography and electromyography were conducted on the vastus lateralis muscle (agonist) and semitendinosus muscle (antagonist) of the subjects with brain lesions...
March 6, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29509335/issue-information-declaration-of-helsinki
#14
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29505469/nasal-glioma-a-rare-cause-of-congenital-inner-canthal-swelling
#15
Norman C Charles, Richard D Lisman, Payal Patel, Alison B Callahan
Nasal glioma, encephalocele, and ectopic brain are rare congenital anomalies. The terminology applied to these entities has been historically confusing. In many cases, the terms overlap and may be employed synonymously although some authors emphasize their differences. The authors describe herein a child with an inner canthal mass of brain-like tissue that they interpret as nasal glioma, a variety of encephalocele that has lost its connection to the intracranial contents. This research was conducted in conformity with the Helsinki Declaration and Health Insurance Portability and Accountability Act regulations...
March 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29490959/design-of-a-phase-iv-randomised-double-blind-placebo-controlled-trial-assessing-the-im-p-act-of-r-esidual-inflammation-detected-via-imaging-t-e-chniques-d-rug-levels-and-patient-characteristics-on-the-outcome-of-dose-taper-i-ng-of-adalimumab-in-c-linical-remission
#16
Paul Emery, Gerd R Burmester, Esperanza Naredo, Yijie Zhou, Maja Hojnik, Philip G Conaghan
INTRODUCTION: The current American College of Rheumatology and European League Against Rheumatism treatment recommendations advise tapering biological disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) who achieve stable clinical remission while receiving bDMARDs. However, not all patients maintain remission or low disease activity after tapering or discontinuation of bDMARDs. The aim of the Im P act of R esidual Inflammation Detected via Imaging T E chniques, D rug Levels and Patient Characteristics on the Outcome of Dose Taper I ng of Adalimumab in C linical Remission Rheumatoid Ar T hritis ( RA ) study, or PREDICTRA, is to generate data on patient and disease characteristics that may predict the clinical course of a fixed dose-tapering regimen with the bDMARD adalimumab...
February 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29486784/energy-nutrient-and-food-content-of-snacks-in-french-adults
#17
Wendy Si Hassen, Katia Castetbon, Christine Tichit, Sandrine Péneau, Anouar Nechba, Pauline Ducrot, Aurélie Lampuré, France Bellisle, Serge Hercberg, Caroline Méjean
BACKGROUND: Snacking raises concern since it may lead to an additional energy intake and poor nutrient quality. A snacking occasion can be defined as any eating occasion apart from main meals, regardless of the amount or type of foods consumed. We described the frequency of snacking occasions according to daily timing in French adults, and compared them between each other, and with the main meals, in terms of energy intake, energy and nutrient density, and food content. METHODS: This cross-sectional analysis included 104,265 adults from the NutriNet-Santé cohort...
February 27, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29484228/the-adverse-effects-of-oral-desmopressin-lyophilisate-melt-personal-experience-on-enuretic-children
#18
Pietro Ferrara, Giulia Franceschini, Serena Mercurio, Ester Del Vescovo, Francesca Ianniello, Tommasangelo Petitti
Objective: The aim of this study was to evaluate adverse effects of oral desmopressin lyophilisate (MELT) in enuretic children. Material and methods: We enrolled 260 children with nocturnal enuresis (NE) referred to the Pediatric Service, 'Campus Bio-Medico' University of Rome, from April 2014 to April 2017 in the study, of these 23 were excluded. The study was characterized by 2 phases. During Phase 1 a careful patient's medical history was obtained and physical examination was performed...
January 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29480460/integrative-physiological-aspects-of-brain-ras-in-hypertension
#19
REVIEW
Sharon D B de Morais, Julia Shanks, Irving H Zucker
PURPOSE OF REVIEW: The renin-angiotensin system (RAS) plays an important role in modulating cardiovascular function and fluid homeostasis. While the systemic actions of the RAS are widely accepted, the role of the RAS in the brain, its regulation of cardiovascular function, and sympathetic outflow remain controversial. In this report, we discuss the current understanding of central RAS on blood pressure (BP) regulation, in light of recent literature and new experimental techniques. RECENT FINDINGS: Studies using neuronal or glial-specifc mouse models have allowed for greater understanding into the site-specific expression and role centrally expressed RAS proteins have on BP regulation...
February 26, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29477983/the-social-value-of-research-interrogating-the-paradoxes
#20
Rakhi Ghoshal
The relation between science and society is, simply put, very complex. In the history of global bioethics, it is the Code of Nuremberg which foregrounded the acute ways in which biomedical/scientific research could (negatively) impact society; this 1947 Code became the point of reference for subsequent research concerning humans. The Code "required that medical experiments on human beings must have the potential to yield fruitful results for the good of society". The Declaration of Helsinki (DoH), 1964 reinstated this concern by stressing that "clinical research cannot be legitimately carried out unless the risks to participants are justified by the importance of the research" - invoking the idea of the "social value" of research...
January 2018: Indian Journal of Medical Ethics
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