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https://www.readbyqxmd.com/read/29040033/lower-eyelid-entropion-repair-with-retractor-mobilization-and-insertion-onto-the-anterior-surface-of-the-tarsal-plate
#1
Dnyaneshwar D Athavale, Brett A O'donnell
PURPOSE: To evaluate a modified surgical technique for the correction of lower eyelid involutional entropion in terms of recurrence rate and relief of symptoms. METHOD: A prospective series of 67 consecutive eyelids in 55 patients who underwent lower eyelid entropion repair using a modified surgical approach not previously published in the literature to the authors' knowledge. The surgical technique, via a skin crease incision, involves disinsertion of the lower eyelid retractors from the tarsus and conjunctiva and suturing the retractors onto the anterior surface of the tarsal plate...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29038625/mucoepidermoid-carcinoma-of-the-salivary-glands-survival-and-prognostic-factors
#2
Guevara-Canales Janet-Ofelia, Morales-Vadillo Rafael, Guzmán-Arias Guillermo, Cava-Vergiú Carlos-Enrique, Robello-Malatto José-Martín, Guerra-Miller Henry, Montes-Gil Jaime-Enrique
OBJECTIVE: The aim of this study was to establish global survival rates and potential prognostic factors for mucoepidermoid carcinoma (MC) of the salivary glands in patients diagnosed at the Dr. Eduardo Cáceres Graziani National Institute for Neoplastic Diseases (INEN), Lima, Peru, between 2002 and 2012. MATERIALS AND METHODS: This was an observational, analytical and longitudinal (information reconstructed in time) retrospective cohort study. Data were obtained from clinical records and used to determine the overall survival (OS) rate at 2 and 5 years, and the individual percentage survival for each prognostic factor using the actuarial technique...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29028134/issue-information-declaration-of-helsinki
#3
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29018526/design-of-the-pf-ild-trial-a-double-blind-randomised-placebo-controlled-phase-iii-trial-of-nintedanib-in-patients-with-progressive-fibrosing-interstitial-lung-disease
#4
Kevin R Flaherty, Kevin K Brown, Athol U Wells, Emmanuelle Clerisme-Beaty, Harold R Collard, Vincent Cottin, Anand Devaraj, Yoshikazu Inoue, Florence Le Maulf, Luca Richeldi, Hendrik Schmidt, Simon Walsh, William Mezzanotte, Rozsa Schlenker-Herceg
600 patients aged ≥18 years will be randomised in a 1:1 ratio to nintedanib or placebo. Patients with diagnosis of IPF will be excluded. The study population will be enriched with two-thirds having a usual interstitial pneumonia-like pattern on HRCT. The primary endpoint is the annual rate of decline in forced vital capacity over 52 weeks. The main secondary endpoints are the absolute change from baseline in King's Brief Interstitial Lung Disease Questionnaire total score, time to first acute interstitial lung disease exacerbation or death and time to all-cause mortality over 52 weeks...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018076/protocol-for-a-prospective-interventional-trial-to-develop-a-diagnostic-index-test-for-stroke-as-a-cause-of-vertigo-dizziness-and-imbalance-in-the-emergency-room-emvert-study
#5
Ken Möhwald, Stanislavs Bardins, Hans-Helge Müller, Klaus Jahn, Andreas Zwergal
INTRODUCTION: Identifying stroke as a cause of acute vertigo, dizziness and imbalance in the emergency room is still a clinical challenge. Many patients are admitted to stroke units, but only a minority will have strokes. This imposes a heavy financial burden on the healthcare system. The aim of this study is to develop a diagnostic index test to identify patients with a high risk of having a stroke as the cause of acute vertigo and imbalance. METHODS AND ANALYSIS: Patients with acute onset of vertigo, dizziness, postural imbalance or double vision within the last 24 hours lasting for at least 10 min are eligible to be included in the study...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28980297/remote-ischemic-preconditioning-of-human-myocardium-ripe-study-protocol-for-a-double-blinded-randomized-controlled-trial
#6
Marek A Deja, Ryszard Wiaderkiewicz, Piotr Czekaj, Ewa Czech, Marcin Malinowski, Leszek Machej, Andrzej Węglarzy, Adam Kowalówka, Magda Piekarska, Bartosz Szurlej, Tomasz Latusek
BACKGROUND: Remote preconditioning was showed to be a potent protective phenomenon in many animals. Several studies aimed to demonstrate it was feasible in humans by trying to show its protective effect during cardiac surgery. Of these studies some small studies and one bigger trial were positive while two other bigger studies showed no effectiveness of remote preconditioning as assessed by levels of postoperatively released cardiac markers. Recently two large clinical trials also failed to prove the benefit of remote preconditioning in cardiac surgery...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28963315/reducing-steroids-in-relapsing-nephrotic-syndrome-the-restern-study-protocol-of-a-national-double-blind-randomised-placebo-controlled-non-inferiority-intervention-study
#7
A M Schijvens, E M Dorresteijn, N Roeleveld, R Ter Heine, J A E van Wijk, A H M Bouts, M G Keijzer-Veen, N C A J van de Kar, L P W J van den Heuvel, M F Schreuder
INTRODUCTION: Oral corticosteroids are the first-line treatment for idiopathic childhood nephrotic syndrome. Most children experience several relapses, needing repeated courses of corticosteroid therapy. This exposes them to side effects and long-term complications. For most patients, long-term prognosis is for complete resolution of the disease over time and maintenance of normal kidney function. Therefore, it is vital to focus on minimising adverse events of the disease and its therapy...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28956967/undertaking-research-on-people-who-lack-decision-making-capacity
#8
Richard Griffith
The Declaration of Helsinki requires that health care research takes place with the informed consent of those who participate in the study. This approach upholds the autonomy of the participants, but restricts research to subjects who have decision-making capacity. The Mental Capacity Act 2005 introduced safeguards that enable researchers to investigate the care and treatment of people with incapacity, while protecting this vulnerable patient group. These safeguards allow people who lack decision-making capacity to benefit from research findings...
October 2, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28952921/four-way-kidney-exchange-transplant-with-desensitization-increases-access-to-living-donor-kidney-transplant-first-report-from-india
#9
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Govind S Kasat, Mayur V Patil, Jaydeep C Patel, Deepak P Kumar, Hargovind L Trivedi
OBJECTIVES: This study reports our experience of the first 4-way kidney exchange transplant combined with desensitization in India, which allows increased access to living-donor kidney transplant for sensitized patients. MATERIALS AND METHODS: Four-way kidney exchange transplant procedures were approved by the ethics committee of our institution and the Organ Transplantation Authorization Committee of state governments of India (as per the Transplantation of Human Organs Act of India)...
September 26, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28947465/cobi-continuous-hyperosmolar-therapy-for-traumatic-brain-injured-patients-trial-protocol-a-multicentre-randomised-open-label-trial-with-blinded-adjudication-of-primary-outcome
#10
Antoine Roquilly, Sigismond Lasocki, Jean Denis Moyer, Olivier Huet, Pierre François Perrigault, Claire Dahyot-Fizelier, Philippe Seguin, Tarek Sharshar, Thomas Geeraerts, Francis Remerand, Fanny Feuillet, Karim Asehnoune
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of death and severe prolonged disability. Intracranial hypertension (ICH) is a critical risk factor of bad outcomes after TBI. Continuous infusion of hyperosmolar therapy has been proposed for the prevention and the treatment of ICH. Whether an early administration of continuous hyperosmolar therapy improves long-term outcomes of patients with TBI is uncertain. The aim of the COBI study (number clinicaltrial.gov 03143751, pre-results stage) is to assess the efficiency and the safety of continuous hyperosmolar therapy in patients with TBI...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28945815/clinical-management-outcomes-of-childhood-glaucoma-suspects
#11
Matthew B Greenberg, Carla J Osigian, Kara M Cavuoto, Ta C Chang
PURPOSE: To investigate the outcomes of childhood glaucoma suspects. DESIGN: Retrospective case series. METHODS: Records of childhood glaucoma suspects were identified using financial claims data; medical history, baseline biometric and exam findings were recorded. Conversion from suspect to glaucoma was determined based on the Childhood Glaucoma Research Network criteria. The study adheres to the tenets of the Declarations of Helsinki. RESULTS: 214 subjects were enrolled, with median age at initial presentation of 6...
2017: PloS One
https://www.readbyqxmd.com/read/28940344/standards-of-care-in-global-health-identifying-the-right-question
#12
Paul Ndebele
Govind Persad and Ezekiel Emanuel's article "The Case for Resource Sensitivity: Why It Is Ethical to Provide Cheaper, Less Effective Treatments in Global Health," in this issue of the Hastings Center Report, is a reminder of the debates around resources for health care that raged during the years immediately preceding and following the fifth revision of the Declaration of Helsinki, in 2000. In global health, it is a common expectation for rich countries to assist poor countries in resolving health challenges, yet global health involves not only the governments of rich and poor nations but also nongovernmental organizations, pharmaceutical companies, the World Health Organization, philanthropic organizations, and other parties-all of whom take roles in ensuring that health interventions become available to poor countries, including deciding which types of interventions to make available...
September 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28912669/identification-of-novel-mutations-in-congenital-afibrinogenemia-patients-and-molecular-modeling-of-missense-mutations-in-pakistani-population
#13
Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S Shamsi, Johannes Oldenburg
BACKGROUND: Congenital afibrinogenemia (OMIM #202400) is a rare coagulation disorder that was first described in 1920. It is transmitted as an autosomal recessive trait that is characterized by absent levels of fibrinogen (factor I) in plasma. Consanguinity in Pakistan and its neighboring countries has resulted in a higher number of cases of congenital fibrinogen deficiency in their respective populations. This study focused on the detection of mutations in fibrinogen genes using DNA sequencing and molecular modeling of missense mutations in all three genes [Fibrinogen gene alpha (FGA), beta (FGB) and gamma (FGG)] in Pakistani patients...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28902090/endocrine-mucin-producing-sweat-gland-carcinoma-of-the-eyelid-associated-with-mucinous-adenocarcinoma
#14
Norman C Charles, Alan D Proia, Christopher Lo
Endocrine mucin-producing sweat gland carcinoma, a rare, low-grade neoplasm with predilection for the eyelids, has been posited as a precursor to invasive mucinous adenocarcinoma. Endocrine mucin-producing sweat gland carcinoma and its concurrence with mucinous adenocarcinoma have received little attention in the ophthalmic literature. The combination of the 2 histologic patterns parallels endocrine ductal carcinoma in situ of the breast and its transition to Type B invasive mucinous carcinoma. The authors describe a 59-year-old man who developed a tumor of the right upper eyelid showing endocrine mucin-producing sweat gland carcinoma in the outer dermis and extensive mucinous carcinoma in the deeper tissue...
September 1, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28869393/ethics-of-clinical-research-in-patients-with-als-is-there-a-risk-of-exploitation
#15
Carmel Armon
Amyotrophic lateral sclerosis is the most common degenerative disease of the motor neuron network. Due to its inevitably fatal outcome, numerous attempts have been made to ameliorate its course. The emergence of every new technology has spurred research to see if it might benefit patients with ALS (PALS). This paper suggests a detailed road map to be followed when performing clinical research in PALS to satisfy the ethics requirements of the Declaration of Helsinki, expressed using the terminology of Beauchamp and Childress...
September 4, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28866123/a-systematic-review-finds-underreporting-of-ethics-approval-informed-consent-and-incentives-in-clinical-trials
#16
Ly Quoc Trung, Mostafa Ebraheem Morra, Nguyen Duc Truong, Tarek Turk, Ahmed Elshafie, Amr Foly, Dao Ngoc Hien Tam, Ahmed Iraqi, Trinh Thi Hong Van, Ahmed Elgebaly, Tran Nhu Ngoc, Tran Le Huy Vu, Ngan Thy Chu, Kenji Hirayama, Juntra Karbwang, Nguyen Tien Huy
OBJECTIVES: In this study, we aim to review researchers' reporting practices of the ethics statement, financial incentives, and local ethical committees' profile in their clinical trials. STUDY DESIGN AND SETTING: A systematic search was done through top-ranked 50 medical journals (Scimago Ranking) to retrieve 2,000 latest publications. Only primary clinical trials were included with no restriction to language or participants. RESULTS: Among the 927 included trials, 14 trials (1...
September 1, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28860228/anterior-transversalis-fascia-approach-versus-preperitoneal-space-approach-for-inguinal-hernia-repair-in-residents-in-northern-china-study-protocol-for-a-prospective-multicentre-randomised-controlled-trial
#17
Qing Fan, De-Wei Zhang, Da-Ye Yang, Hong-Wu Li, Shi-Bo Wei, Liang Yang, Fu-Quan Yang, Shao-Jun Zhang, Yao-Qiang Wu, Wei-de An, Zhong-Shu Dai, Hui-Yong Jiang, Fu-Rong Wang, Shi-Feng Qiao, Hang-Yu Li
INTRODUCTION: Many surgical techniques have been used to repair abdominal wall defects in the inguinal region based on the anatomic characteristics of this region and can be categorised as 'tension' repair or 'tension-free' repair. Tension-free repair is the preferred technique for inguinal hernia repair. Tension-free repair of inguinal hernia can be performed through either the anterior transversalis fascia approach or the preperitoneal space approach. There are few large sample, randomised controlled trials investigating the curative effects of the anterior transversalis fascia approach versus the preperitoneal space approach for inguinal hernia repair in patients in northern China...
August 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28851779/protocol-for-a-randomised-double-masked-sham-controlled-phase-4-study-on-the-efficacy-safety-and-tolerability-of-intravitreal-aflibercept-monotherapy-compared-with-aflibercept-with-adjunctive-photodynamic-therapy-in-polypoidal-choroidal-vasculopathy-the-atlantic
#18
João Pedro Marques, Cláudia Farinha, Miguel Ângelo Costa, Ângela Ferrão, Sandrina Nunes, Rufino Silva
PURPOSE: The purpose of this study is to compare the efficacy and safety of intravitreal aflibercept (IVA) with sham photodynamic therapy (sPDT) versus IVA with verteporfin PDT (vPDT) in a Caucasian population with treatment-naive polypoidal choroidal vasculopathy (PCV), enrolling into a treat and extend (T&E) regimen. METHODS AND ANALYSIS: Randomised, double-masked, sham-controlled, multicentre phase 4 investigator-driven clinical trial. The primary outcomes are (1) change in best-corrected visual acuity (BCVA) from baseline and (2) polyp regression at week 52, assessed by indocyanine green angiography (ICGA)...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28838900/a-patient-cohort-on-long-term-sequelae-of-sepsis-survivors-study-protocol-of-the-mid-german-sepsis-cohort
#19
André Scherag, Christiane S Hartog, Carolin Fleischmann, Dominique Ouart, Franziska Hoffmann, Christian König, Miriam Kesselmeier, Sandra Fiedler, Monique Philipp, Anke Braune, Cornelia Eichhorn, Christin Gampe, Heike Romeike, Konrad Reinhart
INTRODUCTION: An increasing number of patients survive sepsis; however, we lack valid data on the long-term impact on morbidity from prospective observational studies. Therefore, we designed an observational cohort to quantify mid-term and long-term functional disabilities after intensive care unit (ICU)-treated sepsis. Ultimately, findings for the Mid-German Sepsis Cohort (MSC) will serve as basis for the implementation of follow-up structures for patients with sepsis and help to increase quality of care for sepsis survivors...
August 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28833418/conflicting-rationales-leader-s-experienced-ethical-challenges-in-community-health-care-for-older-people
#20
Åshild Slettebø, Ragnhild Skaar, Kari Brodtkorb, Anne Skisland
BACKGROUND: Ethical challenges arise in all types of care, and leaders need to be aware of how to resolve these challenges. Healthcare systems tend to be organised around medical conditions, and the patient is often faced with a series of uncoordinated visits to multiple specialties. Ideally, care should be organised around the patient's needs. AIM: The purpose of this article was to highlight some ethical challenges perceived by leaders with responsibility for management and service distribution, finance and ensuring quality of community health services for older people...
August 22, 2017: Scandinavian Journal of Caring Sciences
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