keyword
https://read.qxmd.com/read/38181296/factors-associated-with-self-perceived-treatment-resistance-in-bipolar-disorder
#21
JOURNAL ARTICLE
Toshimasa Fujimura, Daiki Taira, Yoshihiro Uchida, Keitaro Takahashi, Kanako Yamasuji, Kentaro Shimizu, Yasuhito Nagai, Naoto Yoshinari, Tomoe Hirata, Kazuma Fujimoto, Yui Kurosawa, Seita Yasuda, Akane Yoshikawa, Yoshihide Takeshita, Masanobu Ito, Chihiro Kakiuchi, Tadafumi Kato
Patients with bipolar disorder often report self-perceived treatment resistance. However, it is not known to what extent it is due to actual treatment resistance. The Juntendo University provides "Bipolar Disorder Treatment Rebuilding Program," in which patients with self-reported treatment resistant bipolar disorder are hospitalized for 2 weeks and undergo detailed examinations. In this study, we report our experience with the initial 43 patients hospitalized during the one and half years after the launch of the program...
January 5, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38142892/clinical-outcomes-in-the-biomarkers-of-ketamine-bio-k-study-of-open-label-iv-ketamine-for-refractory-depression
#22
JOURNAL ARTICLE
Sagar V Parikh, Jennifer L Vande Voort, Anastasia K Yocum, Eric Achtyes, Fernando S Goes, Louis Nykamp, Balwinder Singh, Daniela Lopez-Vives, Cortney E Sera, Daniel Maixner, Vijay Tarnal, Jennifer Severe, Steven Bartek, Susannah J Tye, Jose Rico, Cynthia J Stoppel, Alexis Becerra, LeAnn Smart, Christina R Miller, Mark A Frye, John F Greden, William V Bobo
OBJECTIVE: We conducted an open-label clinical trial ("Bio-K") using IV ketamine for treatment-resistant depression to identify biomarkers linked to remission. Here, we report the clinical efficacy and side effect outcomes of Bio-K. METHODS: Across 4 US sites, 75 patients ages 18-65 with treatment-refractory unipolar or bipolar depression received 3 IV ketamine infusions over an 11-day period. Key exclusion criteria were psychotic symptoms, significant substance abuse, unstable medical conditions, and any use of cannabis...
March 1, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38142281/resolving-heterogeneity-in-schizophrenia-bipolar-i-disorder-and-attention-deficit-hyperactivity-disorder-through-individualized-structural-covariance-network-analysis
#23
JOURNAL ARTICLE
Lianjie Niu, Keke Fang, Shaoqiang Han, Chunmiao Xu, Xianfu Sun
Disruptions in large-scale brain connectivity are hypothesized to contribute to psychiatric disorders, including schizophrenia, bipolar I disorder, and attention-deficit/hyperactivity disorder. However, high inter-individual variation among patients with psychiatric disorders hinders achievement of unified findings. To this end, we adopted a newly proposed method to resolve heterogeneity of differential structural covariance network in schizophrenia, bipolar I disorder, and attention-deficit/hyperactivity disorder...
December 23, 2023: Cerebral Cortex
https://read.qxmd.com/read/38137094/enhanced-dynamic-laterality-based-on-functional-subnetworks-in-patients-with-bipolar-disorder
#24
JOURNAL ARTICLE
Dandan Li, Jiangping Hao, Jianchao Hao, Xiaohong Cui, Yan Niu, Jie Xiang, Bin Wang
An ocean of studies have pointed to abnormal brain laterality changes in patients with bipolar disorder (BD). Determining the altered brain lateralization will help us to explore the pathogenesis of BD. Our study will fill the gap in the study of the dynamic changes of brain laterality in BD patients and thus provide new insights into BD research. In this work, we used fMRI data from 48 BD patients and 48 normal controls (NC). We constructed the dynamic laterality time series by extracting the dynamic laterality index ( DLI ) at each sliding window...
November 27, 2023: Brain Sciences
https://read.qxmd.com/read/38129571/classifying-and-clustering-mood-disorder-patients-using-smartphone-data-from-a-feasibility-study
#25
JOURNAL ARTICLE
Carsten Langholm, Scott Breitinger, Lucy Gray, Fernando Goes, Alex Walker, Ashley Xiong, Cindy Stopel, Peter Zandi, Mark A Frye, John Torous
Differentiating between bipolar disorder and major depressive disorder can be challenging for clinicians. The diagnostic process might benefit from new ways of monitoring the phenotypes of these disorders. Smartphone data might offer insight in this regard. Today, smartphones collect dense, multimodal data from which behavioral metrics can be derived. Distinct patterns in these metrics have the potential to differentiate the two conditions. To examine the feasibility of smartphone-based phenotyping, two study sites (Mayo Clinic, Johns Hopkins University) recruited patients with bipolar I disorder (BPI), bipolar II disorder (BPII), major depressive disorder (MDD), and undiagnosed controls for a 12-week observational study...
December 21, 2023: NPJ Digital Medicine
https://read.qxmd.com/read/38113944/common-and-distinct-neural-correlates-of-emotional-processing-in-individuals-at-familial-risk-for-major-depressive-disorder-and-bipolar-disorder-a-comparative-meta-analysis
#26
JOURNAL ARTICLE
Kun Qin, Nanfang Pan, Du Lei, Feifei Zhang, Yifan Yu, John A Sweeney, Melissa P DelBello, Qiyong Gong
Individuals at familial risk for mood disorders exhibit deficits in emotional processing and associated brain dysfunction prior to illness onset. However, such brain-behavior abnormalities related to familial predisposition remain poorly understood. To investigate robust abnormal functional activation patterns during emotional processing in unaffected at-risk relatives of patients with major depressive disorder (UAR-MDD) and bipolar disorder (UAR-BD), we performed a meta-analysis of task-based functional magnetic resonance imaging studies using Seed-based d Mapping (SDM) toolbox...
December 17, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/38111594/functional-alterations-in-patients-with-bipolar-disorder-and-their-unaffected-first-degree-relatives-insight-from-genetic-epidemiological-and-neuroimaging-data
#27
REVIEW
Haonan Zhang, Jun Chen, Yiru Fang
Bipolar disorder (BD) profoundly affects cognitive and psychosocial functioning, leading to a significant illness burden on patients and their families. Genetic factors are predominant in the onset of bipolar disorder and functional impairments. This disorder exhibits a strong family aggregation, with heritability estimates reaching up to 80%. Individuals with BD often experience impaired functioning, especially in significant areas such as physical performance, sleep, cognition, interpersonal interactions, socioeconomic status, family and marital relationships, work and school performance, well-being, and life expectancy...
2023: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38111335/impulsivity-decision-making-and-risk-behavior-in-bipolar-disorder-and-major-depression-from-bipolar-multiplex-families
#28
JOURNAL ARTICLE
Almudena Ramírez-Martín, Lea Sirignano, Fabian Streit, Jerome C Foo, Andreas J Forstner, Josef Frank, Markus M Nöthen, Jana Strohmaier, Stephanie H Witt, Fermin Mayoral-Cleries, Berta Moreno-Küstner, Marcella Rietschel, Jose Guzmán-Parra
OBJECTIVES: Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision-making, and risk-taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision-making, and risk-taking behavior in BD and MDD patients from bipolar multiplex families...
December 18, 2023: Brain and Behavior
https://read.qxmd.com/read/38087387/real-world-predictors-of-divorce-among-outpatients-with-bipolar-disorder-sex-differences-and-clinical-implications
#29
JOURNAL ARTICLE
Keita Tokumitsu, Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Norio Yasui-Furukori
BACKGROUND: Bipolar disorder is a mental illness characterized by recurring episodes of mania and depression and is known to cause social impairment. Additionally, it has been revealed that bipolar disorder increases the risk of divorce and loss of family member support, which can worsen the prognosis. However, there is limited evidence regarding the predictive factors of divorce among patients with bipolar disorder in real-world settings. METHODS: This study utilized an observational approach and involved psychiatrists from 176 member clinics of the Japanese Association of Neuro-Psychiatric Clinics...
December 12, 2023: Annals of General Psychiatry
https://read.qxmd.com/read/38084608/dynamic-structure-function-coupling-across-three-major-psychiatric-disorders
#30
JOURNAL ARTICLE
Zhe Zhang, Wei Wei, Sujie Wang, Mingli Li, Xiaojing Li, Xiaoyu Li, Qiang Wang, Hua Yu, Yamin Zhang, Wanjun Guo, Xiaohong Ma, Liansheng Zhao, Wei Deng, Pak C Sham, Yu Sun, Tao Li
BACKGROUND: Convergent evidence has suggested atypical relationships between brain structure and function in major psychiatric disorders, yet how the abnormal patterns coincide and/or differ across different disorders remains largely unknown. Here, we aim to investigate the common and/or unique dynamic structure-function coupling patterns across major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). METHODS: We quantified the dynamic structure-function coupling in 452 patients with psychiatric disorders (MDD/BD/SZ = 166/168/118) and 205 unaffected controls at three distinct brain network levels, such as global, meso-, and local levels...
December 12, 2023: Psychological Medicine
https://read.qxmd.com/read/38074655/feasibility-of-intraoperative-neuromonitoring-and-cortical-subcortical-mapping-in-patients-with-cerebral-lesions-of-highly-functional-localizations-pathway-to-case-adapted-monitoring-and-mapping-procedures
#31
JOURNAL ARTICLE
Franziska Staub-Bartelt, Marion Rapp, Michael Sabel
BACKGROUND: Intraoperative neuromonitoring (IONM) and mapping procedures via direct cortical stimulation (DCS) are required for resection of eloquently located cerebral lesions. In our neurooncological department, mapping and monitoring are used either combined or separately for surgery of functional lesions. The study aims to provide a practical insight into strengths and pitfalls of intraoperative neuromonitoring and mapping in supratentorial functionally located infiltrating lesions...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38064608/systematic-review-and-meta-analysis-impact-of-various-hemostasis-methods-on-ovarian-reserve-function-in-laparoscopic-cystectomy-for-ovarian-endometriomas
#32
JOURNAL ARTICLE
Xiujuan Gao, Yanan Jin, Guixiang Zhang
BACKGROUND: Ovarian endometriomas, resulting from the invasion of endometriosis into ovarian tissue, can significantly affect ovarian reserve, potentially leading to infertility. When conservative treatments fail, it may further aggravate ovarian reserve decline by invading the ovarian cortex and, in severe cases, result in premature ovarian failure and infertility. OBJECTIVE: This study aimed to investigate the impact of various hemostasis methods on ovarian reserve function in cases of laparoscopic cystectomy for ovarian endometriomas...
December 8, 2023: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38041238/attitudes-of-patients-with-schizophrenia-spectrum-or-bipolar-disorders-towards-medication-self-management-during-hospitalisation
#33
JOURNAL ARTICLE
Elke Loots, Tinne Dilles, Bart Van Rompaey, Manuel Morrens
BACKGROUND: Medication self-management (MSM) is defined as a person's ability to cope with medication treatment for a chronic condition, along with the associated physical and psychosocial effects that the medication causes in their daily lives. For many patients, it is important to be able to self-manage their medication successfully, as they will often be expected to do after discharge. AIM: The aim of this study was to describe the willingness and attitudes of patients with schizophrenia spectrum or bipolar disorders regarding MSM during hospital admission...
December 1, 2023: Journal of Clinical Nursing
https://read.qxmd.com/read/38032730/understanding-mental-health-issues-in-different-subdomains-of-social-networking-services-computational-analysis-of-text-based-reddit-posts
#34
JOURNAL ARTICLE
Seoyun Kim, Junyeop Cha, Dongjae Kim, Eunil Park
BACKGROUND: Users increasingly use social networking services (SNSs) to share their feelings and emotions. For those with mental disorders, SNSs can also be used to seek advice on mental health issues. One available SNS is Reddit, in which users can freely discuss such matters on relevant health diagnostic subreddits. OBJECTIVE: In this study, we analyzed the distinctive linguistic characteristics in users' posts on specific mental disorder subreddits (depression, anxiety, bipolar disorder, borderline personality disorder, schizophrenia, autism, and mental health) and further validated their distinctiveness externally by comparing them with posts of subreddits not related to mental illness...
November 30, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/38025660/a-characteristic-cerebellar-biosignature-for-bipolar-disorder-identified-with-fully-automatic-machine-learning
#35
JOURNAL ARTICLE
Georgios V Thomaidis, Konstantinos Papadimitriou, Sotirios Michos, Evangelos Chartampilas, Ioannis Tsamardinos
BACKGROUND: Transcriptomic profile differences between patients with bipolar disorder and healthy controls can be identified using machine learning and can provide information about the potential role of the cerebellum in the pathogenesis of bipolar disorder.With this aim, user-friendly, fully automated machine learning algorithms can achieve extremely high classification scores and disease-related predictive biosignature identification, in short time frames and scaled down to small datasets...
December 2023: IBRO neuroscience reports
https://read.qxmd.com/read/38004146/vitamin-d-status-in-bipolar-disorder
#36
JOURNAL ARTICLE
Zita Späth, Adelina Tmava-Berisha, Frederike T Fellendorf, Tatjana Stross, Alexander Maget, Martina Platzer, Susanne A Bengesser, Alfred Häussl, Ina Zwigl, Armin Birner, Robert Queissner, Katharina Stix, Linda Wels, Melanie Lenger, Nina Dalkner, Sieglinde Zelzer, Markus Herrmann, Eva Z Reininghaus
Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2 D, and the vitamin D metabolite ratio (VMR) in BD and correlated the results with clinical affective symptomatology and functionality. The inactive precursor 25(OH)D, and its principal catabolite 24,25(OH)2 D, were measured simultaneously with a validated liquid chromatography-tandem mass spectrometry method in 170 BD outpatients and 138 healthy controls...
November 11, 2023: Nutrients
https://read.qxmd.com/read/38003702/can-ashwagandha-benefit-the-endocrine-system-a-review
#37
REVIEW
Michał Wiciński, Anna Fajkiel-Madajczyk, Zuzanna Kurant, Dominik Kurant, Karol Gryczka, Michal Falkowski, Magdalena Wiśniewska, Maciej Słupski, Jakub Ohla, Jan Zabrzyński
Withania somnifera , also known as Ashwagandha, has been used in traditional medicine for thousands of years. Due to the wide range of its activities, there has been interest in its possible beneficial effects on the human body. It is proved that, among others, Ashwagandha has anti-stress, anti-inflammatory, antimicrobial, anti-cancer, anti-diabetic, anti-obesity, cardioprotective, and hypolipidemic properties. Particularly interesting are its properties reported in the field of psychiatry and neurology: in Alzheimer's disease, Parkinson's disease, multiple sclerosis, depression, bipolar disorder, insomnia, anxiety disorders and many others...
November 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37986171/electroconvulsive-therapy-related-anxiety-in-patients-with-depression-the-influence-of-cognitive-coping-styles
#38
JOURNAL ARTICLE
Chelsea Verledens, Jasmien Obbels, Liese Van den Eynde, Eva Pilato, Shauni Verspecht, Kaat Hebbrecht, Emma De Schuyteneer, Kristof Vansteelandt, Pascal Sienaert
INTRODUCTION: Electroconvulsive therapy (ECT) related anxiety (ERA) is a common phenomenon with high individual variability. The way patients cognitively cope with the prospects of receiving ECT could be a mechanism explaining individual differences in ERA. Cognitive coping like monitoring (information seeking, paying attention to consequences) and blunting (seeking distraction and reassurance) has been linked to anxiety in various medical settings, with monitoring leading to more and blunting to less anxiety...
November 20, 2023: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/37961487/sex-stratified-phenotyping-of-comorbidities-associated-with-an-inpatient-delirium-diagnosis-using-real-world-data
#39
Lay Kodama, Sarah Woldemariam, Alice Tang, Yaqiao Li, Tomiko Oskotsky, Eva Raphael, Marina Sirota
UNLABELLED: Delirium is a heterogeneous and detrimental mental condition often seen in older, hospitalized patients and is currently hard to predict. In this study, we leverage large-scale, real- world data using the electronic health records (EHR) to identify two cohorts comprised of 7,492 UCSF patients and 19,417 UC health system patients (excluding UCSF patients) with an inpatient delirium diagnosis and the same number of propensity score-matched control patients without delirium. We found significant associations between comorbidities or laboratory test values and an inpatient delirium diagnosis which were validated independently...
November 4, 2023: medRxiv
https://read.qxmd.com/read/37954601/ankylosing-spondylitis-and-psychiatric-disorders-in-european-population-a-mendelian-randomization-study
#40
JOURNAL ARTICLE
Huifang Zuo, Min-Min Li
BACKGROUND: Epidemiologic evidence has demonstrated a correlation between ankylosing spondylitis and psychiatric disorders. However, little is known about the common genetics and causality of this association. This study aimed to investigate the common genetics and causality between ankylosing spondylitis (AS) and psychiatric disorders. METHODS: A two-sample Mendelian Randomization (MR) analysis was carried out to confirm causal relationships between ankylosing spondylitis and five mental health conditions including major depressive disorder (MDD), anxiety disorder (AXD), schizophrenia (SCZ), bipolar disorder (BIP), and anorexia nervosa (AN)...
2023: Frontiers in Immunology
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