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insight in bipolar patients

Clare Paterson, Yanhong Wang, Thomas M Hyde, Daniel R Weinberger, Joel E Kleinman, Amanda J Law
OBJECTIVE: Genes implicated in schizophrenia are enriched in networks differentially regulated during human CNS development. Neuregulin 3 (NRG3), a brain-enriched neurotrophin, undergoes alternative splicing and is implicated in several neurological disorders with developmental origins. Isoform-specific increases in NRG3 are observed in schizophrenia and associated with rs10748842, a NRG3 risk polymorphism, suggesting NRG3 transcriptional dysregulation as a molecular mechanism of risk...
October 24, 2016: American Journal of Psychiatry
Claire Montlahuc, Emmanuel Curis, Sarah Flora Jonas, Frank Bellivier, Sylvie Chevret
Gaussian mixture analysis is frequently used to model the age-at-onset (AAO) in bipolar I disorder and identify homogeneous subsets of patients. This study aimed to examine whether, using admixture analysis of AAO, cross-sectional designs (which cause right truncation), unreliable diagnosis for individuals younger than 10 years old (which causes left truncation) and the selection criterion used for admixture analysis impact the number of identified subsets. A simulation study was performed. Different criteria - the likelihood ratio test (LRT), the Akaike information criterion (AIC), and the Bayesian information criterion (BIC) - were compared using no, left and/or right truncation simulated data...
October 21, 2016: International Journal of Methods in Psychiatric Research
Boyin Liu, Torsten Bossing
We removed single identified neurons from living Drosophila embryos to gain insight into the transcriptional control of developing neuronal networks. The microarray analysis of the transcriptome of two sibling neurons revealed seven differentially expressed transcripts between both neurons (threshold: log21.4). One transcript encodes the RNA splicing factor B52. Loss of B52 increases growth of axon branches. B52 function is also required for Choline acetyltransferase (ChAT ) splicing. At the end of embryogenesis, loss of B52 function impedes splicing of ChAT, reduces acetylcholine synthesis, and extends the period of uncoordinated muscle twitches during larval hatching...
October 11, 2016: Scientific Reports
Claudia Pisanu, Carla Melis, Alessio Squassina
Preclinical Research Bipolar disorder (BPD) is a chronic and disabling psychiatric disorder with a prevalence of 0.8-1.2% in the general population. Although lithium is considered the first-line treatment, a large percentage of patients do not respond sufficiently. Moreover, lithium can induce severe side effects and has poor tolerance and a narrow therapeutic index. The genetics of lithium response has been largely investigated, but findings have so far failed to identify reliable biomarkers to predict clinical response...
September 16, 2016: Drug Development Research
Joanne H Huang, Shaunna S Berkovitch, Jonathan Iaconelli, Bradley Watmuff, Hyoungjun Park, Shrikanta Chattopadhyay, Donna McPhie, Dost Öngür, Bruce M Cohen, Clary B Clish, Rakesh Karmacharya
Many studies suggest the presence of aberrations in cellular metabolism in bipolar disorder. We studied the metabolome in bipolar disorder to gain insight into cellular pathways that may be dysregulated in bipolar disorder and to discover evidence of novel biomarkers. We measured polar and nonpolar metabolites in fibroblasts from subjects with bipolar I disorder and matched healthy control subjects, under normal conditions and with two physiologic perturbations: low-glucose media and exposure to the stress-mediating hormone dexamethasone...
July 2016: Molecular Neuropsychiatry
Ute Schneider, Lorenz Moser, Marzia Fornasetti, Michele Piattella, Giuseppe Siciliani
INTRODUCTION: The aims of the study were to determine how a panel of orthodontists, dentists, and laypersons rated the esthetic appeal of dentitions after orthodontic space closure by canine substitution compared with space opening and replacement of missing maxillary lateral incisors by implant-borne crowns and to compare the outcome with the results of a study in the United States in 2005. METHODS: A series of 9 posttreatment intraoral frontal photographs was presented to 87 orthodontists, 100 general dentists, and 100 laypersons...
September 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Carlos López-Jaramillo, Chantal Aristizábal Tobler, Constanza Ovalle Gómez, Jaime Escobar Triana
INTRODUCTION: Schizophrenia and bipolar disorder type I (BD-I) can affect patient autonomy and capacity to consent to participate in research. Other variables associated with the autonomy of patients must be explored in order to improve the quality of the currently available tools. OBJECTIVE: To evaluate the relationship between insight and the capacity to consent to participate in research in patients with BD-I and schizophrenia. METHODS: A cross-sectional and longitudinal study was conducted with 120 subjects (40 subjects with schizophrenia, 40 with BD-I, and 40 healthy controls)...
July 2016: Revista Colombiana de Psiquiatría
Yanling Zhou, Robert Rosenheck, Somaia Mohamed, Yufen Ou, Yuping Ning, Hongbo He
BACKGROUND: The difference of burden between caregivers of acute patients with schizophrenia and bipolar disorder has not been well studied in China, a culture where family responsibility has a very high value. Our aim is to compare family burden in these two categories diagnosis and to identify predictors of family burden in a large psychiatric hospital in China. METHODS: Two hundred forty-three schizophrenic patients and 200 bipolar patients were enrolled in a cross-sectional study...
2016: BMC Psychiatry
Judith C L M Duijkers, Constance Th W M Vissers, Jos I M Egger
In mental health, the term dual-diagnosis is used for the co-occurrence of Substance Use Disorder (SUD) with another mental disorder. These co-occurring disorders can have a shared cause, and can cause/intensify each other's expression. Forming a threat to health and society, dual-diagnosis is associated with relapses in addiction-related behavior and a destructive lifestyle. This is due to a persistent failure to control impulses and the maintaining of inadequate self-regulatory behavior in daily life. Thus, several aspects of executive functioning like inhibitory, shifting and updating processes seem impaired in dual-diagnosis...
2016: Frontiers in Psychology
Miroslav Hajda, Jan Prasko, Klara Latalova, Radovan Hruby, Marie Ociskova, Michaela Holubova, Dana Kamaradova, Barbora Mainerova
BACKGROUND: Bipolar disorder (BD) is a serious mental illness with adverse impact on the lives of the patients and their caregivers. BD is associated with many limitations in personal and interpersonal functioning and restricts the patients' ability to use their potential capabilities fully. Bipolar patients long to live meaningful lives, but this goal is hard to achieve for those with poor insight. With progress and humanization of society, the issue of patients' needs became an important topic...
2016: Neuropsychiatric Disease and Treatment
Alessandra Nivoli, Stefano Porcelli, Diego Albani, Gianluigi Forloni, Federica Fusco, Francesc Colom, Eduard Vieta, Alessandro Serretti
BACKGROUND/AIMS: Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleotide-dependent enzymes with a multifaceted role in the central nervous system. The aims of the present study were: (1) to investigate the effects of the rs10997870 SIRT1 gene variant on SB in BD; (2) to explore the effects of the same gene variant on specific depressive symptoms at the severest episode...
July 16, 2016: Neuropsychobiology
Jeffrey M Spielberg, Erik B Beall, Leslie A Hulvershorn, Murat Altinay, Harish Karne, Amit Anand
Research on resting functional brain networks in bipolar disorder (BP) has been unable to differentiate between disturbances related to mania or depression, which is necessary to understand the mechanisms leading to each state. Past research has also been unable to elucidate the impact of BP-related network disturbances on the organizational properties of the brain (eg, communication efficiency). Thus, the present work sought to isolate network disturbances related to BP, fractionate these into components associated with manic and depressive symptoms, and characterize the impact of disturbances on network function...
June 30, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Arul Saravanan Ramachandran, Rajkumar Ramanathan, Samir Kumar Praharaj, Haridas Kanradi, Podila Satya Venkata Narasimha Sharma
AIMS: To study insight correlates in schizophrenia and bipolar mood disorder in remission among out-patients attending the Psychiatry Department of a Tertiary Care Hospital. SETTINGS AND DESIGN: In a cross-sectional, naturalistic study, adult patients with schizophrenia and bipolar mood disorder in remission (n = 80; schizophrenia-40, mania-20, bipolar depression-20) were compared on insight measures and clinical correlates. MATERIALS AND METHODS: Scale to Assess the Unawareness of Mental Disorders (SUMD) was used as the main tool to assess current and past measures of insight...
May 2016: Indian Journal of Psychological Medicine
Saínza García, Mónica Martínez-Cengotitabengoa, Saioa López-Zurbano, Iñaki Zorrilla, Purificación López, Eduard Vieta, Ana González-Pinto
Antipsychotics are the drugs prescribed to treat psychotic disorders; however, patients often fail to adhere to their treatment, and this has a severe negative effect on prognosis in these kinds of illnesses. Among the wide range of risk factors for treatment nonadherence, this systematic review covers those that are most important from the point of view of clinicians and patients and proposes guidelines for addressing them. Analyzing 38 studies conducted in a total of 51,796 patients, including patients with schizophrenia spectrum disorders and bipolar disorder, we found that younger age, substance abuse, poor insight, cognitive impairments, low level of education, minority ethnicity, poor therapeutic alliance, experience of barriers to care, high intensity of delusional symptoms and suspiciousness, and low socioeconomic status are the main risk factors for medication nonadherence in both types of disorder...
August 2016: Journal of Clinical Psychopharmacology
Manuela V Boeira, Gabriela de Á Berni, Ives C Passos, Márcia Kauer-Sant'Anna, Flávio Kapczinski
Family history and traumatic experiences are factors linked to bipolar disorder. It is known that the lifetime risk of bipolar disorder in relatives of a bipolar proband are 5-10% for first degree relatives and 40-70% for monozygotic co-twins. It is also known that patients with early childhood trauma present earlier onset of bipolar disorder, increased number of manic episodes, and more suicide attempts. We have recently reported that childhood trauma partly mediates the effect of family history on bipolar disorder diagnosis...
June 14, 2016: Revista Brasileira de Psiquiatria
Martin Jones, Mellissa Kruger, Sandra M Walsh
UNLABELLED: WHAT IS KNOWN ON THE SUBJECT?: People diagnosed with schizophrenia or bipolar disorder have a life expectancy 10-15 years less than the general population. In rural and remote Australia, there is a shortage of health care professionals to provide physical health care for people living with a serious mental illness (SMI). A large proportion of the care for people living with a SMI is provided by non-government organizations (NGOs), often employing workers without formal qualifications...
June 2016: Journal of Psychiatric and Mental Health Nursing
Philippe Huguelet, Sébastien Guillaume, Sonia Vidal, Sylvia Mohr, Philippe Courtet, Lucile Villain, Chloé Girod, Roland Hasler, Paco Prada, Emilie Olié, Nader Perroud
Recovery is a personal process of growth that involves hope, self-identity, meaning in life and responsibility. Determinants of meaning have not been explored among populations of patients with persistent psychiatric conditions. However, an evidence-based approach aiming at assessing such determinants should provide some insight into the psychotherapeutic aspects of recovery. We tested a model hypothesizing that some symptoms and social parameters of patients are related to values, and secondarily to meaning in life, and in turn that meaning is associated with various parameters, such as depressiveness and self-esteem...
2016: Scientific Reports
Simon Coulombe, Stephanie Radziszewski, Sophie Meunier, Hélène Provencher, Catherine Hudon, Pasquale Roberge, Martin D Provencher, Janie Houle
CONTEXT: A shift toward person-centered care has been occurring in services provided to people with mood and anxiety disorders. Recovery is recognized as encompassing personal aspects in addition to clinical ones. Guidelines now recommend supporting people's engagement in self-management as a complementary recovery avenue. Yet the literature lacks evidence on how individualized combinations of self-management strategies used by people relate to their clinical and personal recovery indicators...
2016: Frontiers in Psychology
Behdin Nowrouzi, Roger S McIntyre, Glenda MacQueen, Sidney H Kennedy, James L Kennedy, Arun Ravindran, Lakshmi Yatham, Vincenzo De Luca
BACKGROUND: Many studies have used the admixture analysis to separate age-at-onset (AAO) subgroups in bipolar disorder, but none of them examined first episode patients. OBJECTIVE: The purpose of this study was to investigate the influence of clinical variables on AAO in first episode bipolar patients. METHODS: The admixture analysis was applied to identify the model best fitting the observed AAO distribution of a sample of 194 patients with DSM-IV diagnosis of bipolar disorder and the finite mixture model was applied to assess the effect of clinical covariates on AAO...
September 1, 2016: Journal of Affective Disorders
Rafael de Assis da Silva, Daniel C Mograbi, Jaqueline Bifano, Cristina M T Santana, Elie Cheniaux
BACKGROUND: Studies on insight in bipolar mania are not numerous and usually consider insight as a unitary construct. OBJECTIVE: Evaluate how different facets of insight are affected in bipolar mania and investigate correlations between insight for each specific object in bipolar disorder and manic symptomatology. METHOD: A group of 165 bipolar patients were followed during a year, with 51 patients having manic episodes according to DSM-IV-TR criteria...
July 15, 2016: Journal of Affective Disorders
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