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https://www.readbyqxmd.com/read/29769459/the-framework-of-clinical-occupational-medicine-to-provide-new-insight-for-workaholism
#1
Quentin Durand-Moreau, Clarisse LE Deun, Brice Lodde, Jean-Dominique Dewitte
There is no single agreed definition of workaholism. Most interventions proposed for people suffering from workaholism target individuals. There is a paucity of descriptions of workplace risk factors. Our study examines case reports of patients suffering from workaholism with a focus on the role of the workplace. We describe case reports from patients of the Occupational Disease Centre in Brest, France between 2013 and 2016. Consultations were conducted within the framework of clinical occupational medicine with a focus on real work situations...
May 17, 2018: Industrial Health
https://www.readbyqxmd.com/read/29757762/corr-insights%C3%A2-how-often-do-acetabular-erosions-occur-after-bipolar-hip-endoprostheses-in-patients-with-malignant-tumors-and-are-erosions-associated-with-outcomes-scores
#2
David D Greenberg
No abstract text is available yet for this article.
May 11, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29751756/prevalence-of-asthma-among-the-adult-general-population-of-five-middle-eastern-countries-results-of-the-snapshot-program
#3
Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
BACKGROUND: Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated. The SNAPSHOT program was conducted to obtain updated information. METHODS: SNAPSHOT is a cross-sectional epidemiological program carried out in five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia, and the United Arab Emirates, the latter three grouped into a Gulf cluster) to collect data on asthma, allergic rhinitis, benign prostatic hyperplasia and bipolar disorder...
May 11, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29736131/the-association-of-insight-and-change-in-insight-with-clinical-symptoms-in-depressed-inpatients
#4
Hongbo He, Qing Chang, Yarong Ma
Background: Lack of insight has been extensively studied and was found to be adversely correlated with impaired treatment compliance and worse long term clinical outcomes among patients with schizophrenia, while not much is known about this phenonmenon in patients with severe depression. Aim: To explore the correlates of insight and its relation to symptom changes among the most seriously ill patients with affective disorders, those who require hospitalization. Methods: Patients hospitalized in a large psychiatric hospital in south China with either major depressive disorder (MDD)(N=55) or bipolar depression (BD) (N=85) based on ICD-10 diagnostic criteria were assessed with the Insight and Treatment Attitudes Questionnaire (ITAQ) one week after admission and at the time of discharge...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29736129/analysis-of-misdiagnosis-of-bipolar-disorder-in-an-outpatient-setting
#5
Hui Shen, Li Zhang, Chuchen Xu, Jinling Zhu, Meijuan Chen, Yiru Fang
Background: Bipolar disorder is a mental illness with a high misdiagnosis rate and commonly misdiagnosed as other mental disorders including depression, schizophrenia, anxiety disorders, obsessive-compulsive disorders, and personality disorders, resulting in the mistreatment of clinical symptoms and increasing of recurrent episodes. Aims: To understand the reasons for misdiagnosis of bipolar disorder in an outpatient setting in order to help clinicians more clearly identify the disease and avoid diagnostic errors...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29720363/users-perspectives-on-mhealth-self-management-of-bipolar-disorder-qualitative-focus-group-study
#6
Lise Switsers, Arthur Dauwe, Anneleen Vanhoudt, Hilde Van Dyck, Koen Lombaerts, Jfe Oldenburg
BACKGROUND: Recent research indicates that current mHealth apps for bipolar disorders (BDs) show crucial shortcomings. They lack important functionality, are of inconsistent quality, and are insufficiently evidence-based. mHealth apps need to be better adapted to the needs of users. The perspectives of adult service users with BD regarding mHealth apps have not been well investigated. OBJECTIVE: The objective of this study was to examine the needs and expectations of adults with BD regarding mHealth apps...
May 2, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29698917/a-mania-related-memory-bias-is-associated-with-risk-for-relapse-in-bipolar-disorder
#7
Thomas D Meyer, Martin Hautzinger, Isabelle E Bauer
OBJECTIVE: Previous work has shown that neuropsychological performance can predict outcome of psychotherapy. The present paper explores whether an affective bias in verbal memory is associated with recurrence of mood episodes in patients with Bipolar Disorder (BD). METHOD: 76 euthymic adult patients with BD were randomly assigned to either 9 months of Cognitive Behavioral Therapy (CBT) or Support Therapy (ST), and followed up for 2 years after completing therapy...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29666369/lithium-associated-transcriptional-regulation-of-crmp1-in-patient-derived-olfactory-neurons-and-symptom-changes-in-bipolar-disorder
#8
Charlee K McLean, Soumya Narayan, Sandra Y Lin, Narayan Rai, Youjin Chung, MariaMananita S Hipolito, Nicola G Cascella, John I Nurnberger, Koko Ishizuka, Akira S Sawa, Evaristus A Nwulia
There is growing evidence that lithium used in the treatment of bipolar disorder (BD) affects molecular targets that are involved in neuronal growth, survival, and maturation, but it remains unclear if neuronal alterations in any of these molecules predict specific symptom changes in BD patients undergoing lithium monotherapy. The goals of this study were to (a) determine which molecular changes in the olfactory neurons of symptomatic patients receiving lithium are associated with antimanic or antidepressant response, and (b) uncover novel intraneuronal regulatory mechanisms of lithium therapy...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29628501/excitatory-and-inhibitory-synaptic-dysfunction-in-mania-an-emerging-hypothesis-from-animal-model-studies
#9
REVIEW
Yeunkum Lee, Yinhua Zhang, Shinhyun Kim, Kihoon Han
Bipolar disorder (BD) is a common psychiatric disorder characterized by recurrent mood swings between depression and mania, and is associated with high treatment costs. The existence of manic episodes is the defining feature of BD, during which period, patients experience extreme elevation in activity, energy, and mood, with changes in sleep patterns that together severely impair their ability to function in daily life. Despite some limitations in recapitulating the complex features of human disease, several rodent models of mania have been generated and characterized, which have provided important insights toward understanding its underlying pathogenic mechanisms...
April 9, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29618019/differential-expression-of-synapsin-i-and-ii-upon-treatment-by-lithium-and-valproic-acid-in-various-brain-regions
#10
Hetshree Joshi, Roohie Sharma, Shreya Prashar, Joella Ho, Sharon Thomson, Ram Mishra
Introduction: Due to the heterogeneity of psychiatric illnesses and overlapping mechanisms, patients with psychosis are differentially responsive to pharmaceutical drugs. In addition to having therapeutic effects for schizophrenia and bipolar disorder, antipsychotics and mood stabilizers have many clinical applications and are used unconventionally due to their direct and indirect effects on neurotransmitters. Synapsins, a family of neuronal phosphoproteins, play a key regulatory role in neurotransmitter release at synapses...
March 30, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29580768/functional-connectivity-between-anterior-insula-and-key-nodes-of-frontoparietal-executive-control-and-salience-networks-distinguish-bipolar-depression-from-unipolar-depression-and-healthy-control-subjects
#11
Kristen K Ellard, Jared P Zimmerman, Navneet Kaur, Koene R A Van Dijk, Joshua L Roffman, Andrew A Nierenberg, Darin D Dougherty, Thilo Deckersbach, Joan A Camprodon
BACKGROUND: Patients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment...
February 7, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29522943/distinct-patterns-of-blood-oxygenation-in-the-prefrontal-cortex-in-clinical-phenotypes-of-schizophrenia-and-bipolar-disorder
#12
Kazuhiko Yamamuro, Sohei Kimoto, Junzo Iida, Naoko Kishimoto, Shohei Tanaka, Michihiro Toritsuka, Daisuke Ikawa, Yasunori Yamashita, Toyosaku Ota, Manabu Makinodan, Hiroki Yoshino, Toshifumi Kishimoto
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are characterized by different clinical symptoms, and have previously been considered as categorically separate. However, several lines of evidence controversially suggest that these two disorders may run on a continuum. While it is therefore important to evaluate the subtle differences between SZ and BD, few studies have investigated the difference of brain functioning between the two by focusing on the common symptoms of cognitive functioning and impulsivity, rather than positive/negative and mood symptoms...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29517871/-lithium-toxicity-after-bariatric-surgery
#13
R Niessen, T Sottiaux, A Schillaci, F Lejeune
Since many years a correlation between neuropsychiatric disorders and eating disorders resulting in obesity is well established. According to different studies, 1.2 - 4 % of patients scheduled for bariatric surgery are taking lithium as a mood stabilizer treatment for bipolar disorder. We are presenting a case of lithium toxicity after vertical sleeve gastrectomy surgery in a 40 years-old female. The patient developed severe neurological and renal signs needing an intensive care unit admission and continuous veno-venous hemodiafiltration...
February 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29486891/dynamic-changes-of-the-mitochondria-in-psychiatric-illnesses-new-mechanistic-insights-from-human-neuronal-models
#14
REVIEW
Rupali Srivastava, Travis Faust, Adriana Ramos, Koko Ishizuka, Akira Sawa
Mitochondria play a crucial role in neuronal function, especially in energy production, the generation of reactive oxygen species, and calcium signaling. Multiple lines of evidence have suggested the possible involvement of mitochondrial deficits in major psychiatric disorders, such as schizophrenia and bipolar disorder. This review will outline the current understanding of the physiological role of mitochondria and their dysfunction under pathological conditions, particularly in psychiatric disorders. The current knowledge about mitochondrial deficits in these disorders is somewhat limited because of the lack of effective methods to dissect dynamic changes in functional deficits that are directly associated with psychiatric conditions...
May 1, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29419640/a-mixed-program-of-psychoeducational-and-psychological-rehabilitation-for-patients-with-bipolar-disorder-in-a-day-hospital-setting
#15
Giovanni Camardese, Massimo Vasale, Lucio DʼAlessandris, Marianna Mazza, Riccardo Serrani, Federico Travagliati, Coco Walstra, Leonardo Zaninotto, Beniamino Leone, Marco Di Nicola, Raffaella Franza, Giuseppe Marano, Lucio Rinaldi, Luigi Janiri
The present study describes a new mixed program of psychoeducational and psychological interventions for bipolar patients, applicable during everyday practice. Thirty-two bipolar patients recruited at a psychiatric day-hospital service have been admitted to a program consisting of 30 meetings and 2 follow-ups at 6 and 12 months. The psychoeducational support determined a general improvement of all included patients. At baseline, patients with residual depression had higher Hamilton Depression Rating Scale (HDRS) scores than euthymic patients (mean score ± SD: 21...
April 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29366907/electrodiagnostic-applications-of-somatosensory-evoked-high-frequency-eeg-oscillations-technical-considerations
#16
A J Simpson, M O Cunningham, M R Baker
INTRODUCTION: High frequency oscillations (HFOs) embedded within the somatosensory evoked potential (SEP) are not routinely recorded/measured as part of standard clinical SEPs. However, HFOs could provide important additional diagnostic/prognostic information in various patient groups in whom SEPs are tested routinely. One area is the management of patients with hypoxic ischaemic encephalopathy (HIE) in the intensive care unit (ICU). However, the sensitivity of standard clinical SEP recording techniques for detecting HFOs is unknown...
March 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29352661/mechanistic-insights-into-the-genetics-of-affective-psychosis-from-prader-willi-syndrome
#17
REVIEW
Lucie C S Aman, Katherine E Manning, Joyce E Whittington, Anthony J Holland
Schizophrenia and bipolar disorder are common, severe, and disabling psychotic disorders, which are difficult to research. We argue that the genetically determined neurodevelopmental disorder Prader-Willi syndrome (PWS), which is associated with a high risk of affective psychotic illness, can provide a window into genetic mechanisms and associated neural pathways. People with PWS can all show non-psychotic psychopathology and problem behaviours, but the prevalence of psychotic illness differs markedly by genetic subtype; people with PWS due to chromosome 15 maternal uniparental disomy have higher prevalence of psychotic illness compared with patients with PWS due to 15q11-13 deletions of paternal origin...
April 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29230399/role-of-protein-kinase-c-in-bipolar-disorder-a-review-of-the-current-literature
#18
REVIEW
Ashwini Saxena, Giselli Scaini, Daniela V Bavaresco, Camila Leite, Samira S Valvassoria, André F Carvalho, João Quevedo
Bipolar disorder (BD) is a major health problem. It causes significant morbidity and imposes a burden on the society. Available treatments help a substantial proportion of patients but are not beneficial for an estimated 40-50%. Thus, there is a great need to further our understanding the pathophysiology of BD to identify new therapeutic avenues. The preponderance of evidence pointed towards a role of protein kinase C (PKC) in BD. We reviewed the literature pertinent to the role of PKC in BD. We present recent advances from preclinical and clinical studies that further support the role of PKC...
November 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29145187/diogenes-syndrome
#19
Frédéric Assal
Diogenes syndrome (DS) is not a specific disease but a real neurobehavioral syndrome, characterized by severe domestic squalor, pathological hoarding, lack of insight into the condition, and no need for help. DS can be secondary when associated to psychosis or bipolar disorder, or primary when it occurs as a single entity, usually in the elderly. DS is a clinically complex transnosographic syndrome for which multidimensional approaches need to be considered: medical, psychiatric, neurological, social, scientific, and ethical...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29137178/antidepressants-and-mood-stabilizers-novel-research-avenues-and-clinical-insights-for-bipolar-depression
#20
REVIEW
In Hee Shim, Young Sup Woo, Moon-Doo Kim, Won-Myong Bahk
The concept of the bipolar-spectrum and of mixed features being a bridge between major depressive disorders and bipolar disorders (BDs) has become increasingly important in mood-disorder diagnoses. Under these circumstances, antidepressants (ADs) and mood stabilizers (MSs) should be used with caution in the treatment of major depressive episodes (MDEs) and to obtain long-term stability in BDs. Before treating MDEs, screening tools, specific symptom evaluation and medical history should be used to distinguish between bipolarity and mixed features in patients for whom AD monotherapy may present a risk...
November 13, 2017: International Journal of Molecular Sciences
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