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https://www.readbyqxmd.com/read/29145187/diogenes-syndrome
#1
Frédéric Assal
Diogenes syndrome (DS) is not a specific disease but a real neurobehavioral syndrome, characterized by severe domestic squalor, pathological hoarding, lack of insight into the condition, and no need for help. DS can be secondary when associated to psychosis or bipolar disorder, or primary when it occurs as a single entity, usually in the elderly. DS is a clinically complex transnosographic syndrome for which multidimensional approaches need to be considered: medical, psychiatric, neurological, social, scientific, and ethical...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29137178/antidepressants-and-mood-stabilizers-novel-research-avenues-and-clinical-insights-for-bipolar-depression
#2
REVIEW
In Hee Shim, Young Sup Woo, Moon-Doo Kim, Won-Myong Bahk
The concept of the bipolar-spectrum and of mixed features being a bridge between major depressive disorders and bipolar disorders (BDs) has become increasingly important in mood-disorder diagnoses. Under these circumstances, antidepressants (ADs) and mood stabilizers (MSs) should be used with caution in the treatment of major depressive episodes (MDEs) and to obtain long-term stability in BDs. Before treating MDEs, screening tools, specific symptom evaluation and medical history should be used to distinguish between bipolarity and mixed features in patients for whom AD monotherapy may present a risk...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29070081/understanding-the-experience-of-initiating-community-based-physical-activity-and-social-support-by-people-with-serious-mental-illness-a-systematic-review-using-a-meta-ethnographic-approach
#3
Helen Quirk, Helen Crank, Deborah Harrop, Emma Hock, Robert Copeland
BACKGROUND: People with long-term serious mental illness live with severe and debilitating symptoms that can negatively influence their health and quality of life, leading to outcomes such as premature mortality, morbidity and obesity. An interplay of social, behavioural, biological and psychological factors is likely to contribute to their poor physical health. Participating in regular physical activity could bring symptomatic improvements, weight loss benefits, enhanced wellbeing and when undertaken in a community-based group setting can yield additional, important social support benefits...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29067142/intermittent-96-hour-auricular-electroacupuncture-for-hot-flashes-in-patients-with-prostate-cancer-a-pilot-study
#4
Tyvin Rich, Gerald W Porter, Luisel Ricks-Santi, Tzvi Milshtein, Thomas Corbin
Objective: The hot flash is a common vasomotor disorder that causes distress in menopausal women and that can be debilitating in men with prostate cancer who are treated with androgen deprivation therapy (ADT). The utility of auricular electroacupuncture (AEA) was tested exclusively for a small cohort of men with ADT-induced vasomotor symptoms while the men underwent a course of curative radiotherapy. Materials and Methods: Prior to and during radiotherapy treatment, men with vasomotor symptoms were given repeated questionnaires regarding severity and frequency of hot flashes, quality of life (QoL), and sleep over a 6-week span of an AEA protocol...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29027157/animal-models-for-bipolar-disorder-from-bedside-to-the-cage
#5
REVIEW
Dominik K E Beyer, Nadja Freund
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense of self, self-esteem, circadian rhythm, cognition, and increased risk for suicide. Effective treatment options are limited and diagnosis can be complicated. To overcome these obstacles, a better understanding of the neurobiology underlying bipolar disorder is needed...
October 13, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29021854/left-atrial-remodeling-regional-differences-between-paroxysmal-and-persistent-atrial-fibrillation
#6
Rikitake Kogawa, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Keiko Takahashi, Kazuki Iso, Ryuta Watanabe, Masaru Arai, Sayaka Kurokawa, Kimie Ohkubo, Toshiko Nakai, Atsushi Hirayama, Kazumasa Sonoda, Toshimasa Tosaka
BACKGROUND: The mechanisms underlying self-perpetuation of persistent atrial fibrillation (AF) are not well understood. To gain insight into these mechanisms, we conducted a study comparing left atrial (LA) electroanatomic maps obtained during sinus rhythm between patients with paroxysmal AF (PAF) and patients with persistent AF (PerAF). METHODS: The study included 23 men with PAF (age, 56.3±12.1 years) and 13 men with PerAF (age, 54.3±13.4 years). LA voltage mapping was performed during sinus rhythm...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28978249/the-influence-of-coercive-measures-on-patients-stances-towards-psychiatric-institutions
#7
Juliane Mielau, Jasmin Altunbay, Anja Lehmann, Felix Bermpohl, Andreas Heinz, Christiane Montag
OBJECTIVE: To examine the impact of coercive interventions (CI) on patients' evaluations of psychiatric hospitals as adversaries versus allies. METHODS: Self-constructed interviews were conducted relating to quantitative and subjective aspects of coercion and the attitude towards psychiatry of 79 patients with psychotic and bipolar disorders. The Coercion Experience Scale (CES) and the Admission Experience Survey (AES) were used to establish the subjective impact of CI...
October 5, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28953761/a-review-of-the-efficacy-and-role-of-the-card-sort-exercise-in-the-treatment-of-bipolar-disorder
#8
Paul Jie Wen Tern, Ali Abdaal, Jake Tobin, Katherine Macfarland, Molly Hunt, Mark Agius
The current card sort exercise described by Agius et al. in 2006 provides a tool for patients and their families to characterise the temporal pattern of occurrence of both stereotyped and idiosyncratic prodromal symptoms that serve as early warning signs predicting a relapse. This 'individual relapse signature' is highly specific for bipolar relapse, and aids identification of a relapse such that patients can be channeled into appropriate early intervention pathways. This review examines the role of the card sort exercise in the treatment of bipolar disorder, and evaluates the evidence for its efficacy...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28936160/the-energy-metabolism-dysfunction-in-psychiatric-disorders-postmortem-brains-focus-on-proteomic-evidence
#9
REVIEW
Giuliana S Zuccoli, Verônica M Saia-Cereda, Juliana M Nascimento, Daniel Martins-de-Souza
Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfunction in energy metabolism is one of the most consistent scientific findings associated with these disorders. With this is mind, this review compiled data on disturbances in energy metabolism found by proteomic analyses of postmortem brains collected from patients affected by the most prevalent psychiatric disorders: schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28751151/development-of-refractive-errors-what-can-we-learn-from-inherited-retinal-dystrophies
#10
MULTICENTER STUDY
Michelle Hendriks, Virginie J M Verhoeven, Gabriëlle H S Buitendijk, Jan Roelof Polling, Magda A Meester-Smoor, Albert Hofman, Maarten Kamermans, L Ingeborgh van den Born, Caroline C W Klaver
PURPOSE: It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and have a high risk of refractive errors, a study investigating the affected cell type, causal gene, and refractive error in IRDs may provide insight herein. DESIGN: Case-control study. METHODS: Study Population: Total of 302 patients with IRD from 2 ophthalmogenetic centers in the Netherlands...
October 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730651/a-comparison-of-the-electrophysiologic-and-electroanatomic-characteristics-between-the-right-and-left-atrium-in-persistent-atrial-fibrillation-is-the-right-atrium-a-window-into-the-left
#11
Sandeep Prabhu, Aleksandr Voskoboinik, Alex J A McLellan, Kah Y Peck, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
INTRODUCTION: The right atrium (RA) is readily accessible; however, it is unclear whether changes in the RA are representative of the LA. We performed detailed biatrial electroanatomic mapping to determine the electrophysiological relationship between the atria. METHODS AND RESULTS: Consecutive patients with persistent AF underwent biatrial electroanatomical mapping with a contact force catheter acquiring points with a CF >10 g prior to ablation. Points were analyzed for tissue voltage, complex electrograms, low voltage (<0...
October 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28728937/the-impact-of-machine-learning-techniques-in-the-study-of-bipolar-disorder-a-systematic-review
#12
REVIEW
Diego Librenza-Garcia, Bruno Jaskulski Kotzian, Jessica Yang, Benson Mwangi, Bo Cao, Luiza Nunes Pereira Lima, Mariane Bagatin Bermudez, Manuela Vianna Boeira, Flávio Kapczinski, Ives Cavalcante Passos
Machine learning techniques provide new methods to predict diagnosis and clinical outcomes at an individual level. We aim to review the existing literature on the use of machine learning techniques in the assessment of subjects with bipolar disorder. We systematically searched PubMed, Embase and Web of Science for articles published in any language up to January 2017. We found 757 abstracts and included 51 studies in our review. Most of the included studies used multiple levels of biological data to distinguish the diagnosis of bipolar disorder from other psychiatric disorders or healthy controls...
July 18, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28706826/arthroscopic-panlabral-repair-with-remplissage-of-hill-sachs-lesion
#13
Colten Luedke, John M Tokish
Recurrent shoulder instability in young contact athletes has been well established. The importance of bipolar bone loss in instability has come to the forefront in terms of proper management of this condition. It remains controversial, however, which patients would be better served with an arthroscopic versus open procedure and when additional procedures may reduce the risk of failure (i.e., remplissage). We present our arthroscopic technique of a panlabral repair with concomitant remplissage using the double-pulley technique...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28702349/distinct-multivariate-brain-morphological-patterns-and-their-added-predictive-value-with-cognitive-and-polygenic-risk-scores-in-mental-disorders
#14
Nhat Trung Doan, Tobias Kaufmann, Francesco Bettella, Kjetil Nordbø Jørgensen, Christine Lycke Brandt, Torgeir Moberget, Dag Alnæs, Gwenaëlle Douaud, Eugene Duff, Srdjan Djurovic, Ingrid Melle, Torill Ueland, Ingrid Agartz, Ole A Andreassen, Lars T Westlye
The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is known about the complementary clinical value of brain structural phenotypes when combined with data on cognitive performance and genetic risk. Using data-driven fusion of cortical thickness, surface area, and gray matter density maps (GMD), we found six biologically meaningful patterns showing strong group effects, including four statistically independent multimodal patterns reflecting co-occurring alterations in thickness and GMD in patients, over and above two other independent patterns of widespread thickness and area reduction...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28628109/truncating-mutations-in-rbm12-are-associated-with-psychosis
#15
Stacy Steinberg, Steinunn Gudmundsdottir, Gardar Sveinbjornsson, Jaana Suvisaari, Tiina Paunio, Minna Torniainen-Holm, Michael L Frigge, Gudrun A Jonsdottir, Johanna Huttenlocher, Sunna Arnarsdottir, Oddur Ingimarsson, Magnus Haraldsson, Thorarinn Tyrfingsson, Thorgeir E Thorgeirsson, Augustine Kong, Gudmundur L Norddahl, Daniel F Gudbjartsson, Engilbert Sigurdsson, Hreinn Stefansson, Kari Stefansson
Thus far, a handful of highly penetrant mutations conferring risk of psychosis have been discovered. Here we used whole-genome sequencing and long-range phasing to investigate an Icelandic kindred containing ten individuals with psychosis (schizophrenia, schizoaffective disorder or psychotic bipolar disorder). We found that all affected individuals carry RBM12 (RNA-binding-motif protein 12) c.2377G>T (P = 2.2 × 10(-4)), a nonsense mutation that results in the production of a truncated protein lacking a predicted RNA-recognition motif...
August 2017: Nature Genetics
https://www.readbyqxmd.com/read/28558365/reward-anticipation-revisited-evidence-from-an-fmri-study-in-euthymic-bipolar-i-patients-and-healthy-first-degree-relatives
#16
Bianca Kollmann, Vanessa Scholz, Julia Linke, Peter Kirsch, Michèle Wessa
BACKGROUND: Symptomatic phases in bipolar disorder (BD) are hypothesized to result from a hypersensitive behavioral activation system (BAS) being sensitive to potential rewards. However, studies on the neuronal underpinnings of reward anticipation in BD are scarce with contradictory findings and possibly confounded by effects of dopaminergic medication, necessitating further research on dysfunctional motivation in BD. Moreover, its role as vulnerability marker for BD is unclear. METHODS: Functional imaging was conducted in 16 euthymic BD-I patients free from dopaminergic medication and 19 healthy first-degree relatives using a monetary incentive delay task and compared to parallelized control groups...
May 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28554235/the-influence-of-current-mood-state-number-of-previous-affective-episodes-and-predominant-polarity-on-insight-in-bipolar-disorder
#17
Rafael de Assis da Silva, Daniel C Mograbi, Evelyn Vieira Miranda Camelo, Ursula Peixoto, Cristina Maria Teixeira Santana, Jesus Landeira-Fernandez, Robin G Morris, Elie Cheniaux
BACKGROUND: Although many studies have explored the effect of current affective episodes on insight into bipolar disorder, the potential interaction between current mood state and previous affective episodes has not been consistently investigated. OBJECTIVE: To explore the influence of dominant polarity, number of previous affective episodes and current affective state on insight in bipolar disorder patients in euthymia or mania. METHODS: A total of 101 patients with bipolar disorder were recruited for the study, including 58 patients in euthymia (30 with no defined predominant polarity and 28 with manic predominant polarity) and 43 in mania (26 with no defined predominant polarity and 17 with manic predominant polarity)...
May 30, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28546141/clinical-insight-into-latent-variables-of-psychiatric-questionnaires-for-mood-symptom-self-assessment
#18
Athanasios Tsanas, Kate Saunders, Amy Bilderbeck, Niclas Palmius, Guy Goodwin, Maarten De Vos
BACKGROUND: We recently described a new questionnaire to monitor mood called mood zoom (MZ). MZ comprises 6 items assessing mood symptoms on a 7-point Likert scale; we had previously used standard principal component analysis (PCA) to tentatively understand its properties, but the presence of multiple nonzero loadings obstructed the interpretation of its latent variables. OBJECTIVE: The aim of this study was to rigorously investigate the internal properties and latent variables of MZ using an algorithmic approach which may lead to more interpretable results than PCA...
May 25, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28501741/executive-functioning-deficits-among-adults-with-bipolar-disorder-types-i-and-ii-a-systematic-review-and-meta-analysis
#19
REVIEW
Tania Dickinson, Rodrigo Becerra, Jacqui Coombes
BACKGROUND: Executive functioning (EF) deficits contribute to a significant proportion of the burden of disease associated with bipolar disorder (BD). Yet, there is still debate in the literature regarding the exact profile of executive functioning in BD. The purpose of the present project was to assess whether EF deficits exist among adults suffering BD, and whether these deficits (if apparent) differ by BD subtype. METHODS: A systematic search identified relevant literature...
April 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28500272/probing-the-lithium-response-pathway-in-hipscs-implicates-the-phosphoregulatory-set-point-for-a-cytoskeletal-modulator-in-bipolar-pathogenesis
#20
Brian T D Tobe, Andrew M Crain, Alicia M Winquist, Barbara Calabrese, Hiroko Makihara, Wen-Ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D Sheridan, Ryan W Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C B Basa, Michael J McCarthy, Namrata D Udeshi, Philipp Mertins, Steven A Carr, Guy A Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J Gutierrez, Laurence M Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S Nye, Husseini Manji, Jeffrey H Price, Colleen A McClung, Hagop S Akiskal, Martin Alda, De-Maw M Chuang, Joseph T Coyle, Yang Liu, Yang D Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L Sidman, Shelley Halpain, Stephen J Haggarty, Yoshio Goshima, Evan Y Snyder
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling the proteomics of BDP-hiPSC-derived neurons, we found that lithium alters the phosphorylation state of collapsin response mediator protein-2 (CRMP2)...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
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