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https://www.readbyqxmd.com/read/29671497/osteoarthritis-rapid-evidence-review
#1
Mark H Ebell
Osteoarthritis (OA) should be suspected in patients with pain in the fingers, shoulders, hips, knees, or ankles, especially if they are older than 40 years. Patients older than 50 years who have joint pain, minimal morning stiffness, and functional impairment likely have OA. Radiography can confirm the diagnosis and may be helpful before surgical referral, but findings generally do not correlate well with symptoms. Exercise, physical therapy, knee taping, and tai chi are beneficial for knee OA. Medical therapy provides modest benefits in pain reduction and functional improvement; however, nonsteroidal anti-inflammatory drugs, tramadol, and other opioids have significant potential harms...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#2
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29644468/-pharmacological-treatment-of-osteoarthritis-related-pain
#3
REVIEW
T A Nees, M Schiltenwolf
Joint pain due to osteoarthritis (OA) is often severe and disabling and affects a large proportion of the aging population impairing daily living and quality of life. Numerous pharmacological treatment approaches are available. Including major OA guidelines this review presents the current evidence of pharmacological therapies in OA-related pain and covers topical, oral and intraarticular treatment approaches. In patients with mild OA topical nonsteroidal antiinflammatory drugs (NSAIDs) can be recommended...
April 11, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29568025/are-pharmacological-treatments-for-oro-facial-pain-effective
#4
Debra Fischoff, Silvia Spivakovsky
Data sourcesElectronic searches of PubMed, the Cochrane Library, Embase, the National Health Service Economic Evaluation Database and HTA until March 2017. Also handsearched referenced in the original articles. Grey literature was not included.Study selectionRandomised controlled trials with more than ten participants with oro-facial pain duration of more than three months were sub grouped into: TMD-muscle pain (TMD-m), TMD-joint pain (TMD-j), burning mouth syndrome (BMS) and other oro-facial pain. Studies include any pharmacological treatment against another pharmacological, non-pharmacological treatment, placebo or no treatment...
March 23, 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29560329/comparison-between-extracorporeal-shock-wave-therapy-and-intra-articular-hyaluronic-acid-injections-in-the-treatment-of-first-carpometacarpal-joint-osteoarthritis
#5
Francesco Ioppolo, Fabiana Saracino, Rosaria Sabrina Rizzo, Giampaolo Monacelli, Danilo Lanni, Luca Di Sante, Angelo Cacchio, Valter Santilli, Teresa Venditto
Objective: To compare extracorporeal shockwave therapy (ESWT) with hyaluronic acid (HA) intra-articular injections in terms of pain relief, improvement in hand function, and strength in subjects with first carpometacarpal (CMC) joint osteoarthritis. Methods: Fifty-eight patients received either focused ESWT or HA injection once a week for 3 consecutive weeks. In the ESWT group, 2,400 consecutive pulses were performed during each treatment session using a frequency of 4 Hz and an energy flux density of 0...
February 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29560045/use-of-mesenchymal-stem-cells-seeded-on-the-scaffold-in-articular-cartilage-repair
#6
REVIEW
Kaoru Yamagata, Shingo Nakayamada, Yoshiya Tanaka
Articular cartilage has poor capacity for repair. Once damaged, they degenerate, causing functional impairment of joints. Allogeneic cartilage transplantation has been performed for functional recovery of articular cartilage. However, there is only a limited amount of articular cartilage available for transplantation. Mesenchymal stem cells (MSCs) could be potentially suitable for local implantation. MSCs can differentiate into chondrocytes. Several studies have demonstrated the therapeutic potential of MSCs in the repair of articular cartilage in animal models of articular cartilage damage and in patients with damaged articular cartilage...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29542009/a-comparison-between-rheological-properties-of-intra-articular-hyaluronic-acid-preparations-and-reported-human-synovial-fluid
#7
Mat Nicholls, Ajay Manjoo, Peter Shaw, Faizan Niazi, Jeffrey Rosen
INTRODUCTION: This study aims to compare the properties of currently available intra-articular hyaluronate (IA-HA) products widely available in the USA to those of healthy knee synovial fluid with respect to their bulk rheological properties. We hypothesize that products would have differing rheological properties, with some more closely resembling the properties and physiological aspects of healthy joint fluid HA. METHODS: We obtained reported HA product molecular weights, as well as measurements of the presence of cross-linking, zero shear rate viscosity, shear thinning ratio, and crossover frequency for the following IA-HA products available in the USA: Euflexxa® , Orthovisc® , Supartz® , Monovisc® , Synvisc® , Synvisc-One® , Gel-One® , and Hyalgan® ...
March 14, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29531292/label-free-analysis-of-physiological-hyaluronan-size-distribution-with-a-solid-state-nanopore-sensor
#8
Felipe Rivas, Osama K Zahid, Heidi L Reesink, Bridgette T Peal, Alan J Nixon, Paul L DeAngelis, Aleksander Skardal, Elaheh Rahbar, Adam R Hall
Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in numerous physiological functions in vivo, including tissue hydration, inflammation, and joint lubrication. Both the abundance and size distribution of HA in biological fluids are recognized as robust indicators of various pathologies and disease progressions. However, such analyses remain challenging because conventional methods are not sufficiently sensitive, have limited dynamic range, and/or are only semi-quantitative...
March 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29525231/effect-of-an-oral-joint-supplement-when-compared-to-carprofen-in-the-management-of-hip-osteoarthritis-in-working-dogs
#9
João Carlos Alves, Ana Margarida Santos, Patrícia Isabel Jorge
The goal of this study was to evaluate the effectiveness of an oral joint supplement in working dogs with hip osteoarthritis compared with a positive control group (CG). Fifteen animals were divided in treatment group (TG, n = 10) and CG (n = 5). To TG a commercially available joint supplement, containing glucosamine HCl, chondroitin sulphate, and hyaluronic acid was given for 40 days and a 70-day course of a placebo, to be administered as if it was carprofen. The CG received carprofen for 70 days, and a placebo to be administered as the joint supplement...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29524557/enhanced-anti-tumor-efficacy-of-temozolomide-loaded-carboxylated-poly-amido-amine-combined-with-photothermal-photodynamic-therapy-for-melanoma-treatment
#10
Jianqin Tang, Huige Zhou, Xiaoyang Hou, Liming Wang, Yaxi Li, Yanyu Pang, Chunying Chen, Guan Jiang, Yanqun Liu
Chemotherapy is an important treatment for malignant tumors; however, its efficacy and clinical application are limited by its side effects and drug resistance properties. Chemotherapy and phototherapy exhibit synergistic anti-tumor effects. In the present study, a carboxylated poly(amido-amine) (PAMAM) with low cytotoxicity was synthesized as a delivery nanocarrier for loading chemotherapeutic drugs, temozolomide (TMZ), and fluorescent dye indocyanine green (ICG). Hyaluronic acid (HA), which targets the CD44-overexpressing cancer cells, was modified on the nanocarrier surface to enhance the selective killing of melanoma cells...
March 7, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29516758/targeted-delivery-of-hyaluronic-acid-coated-solid-lipid-nanoparticles-for-rheumatoid-arthritis-therapy
#11
Meiling Zhou, Jierong Hou, Zhirong Zhong, Na Hao, Yan Lin, Chunhong Li
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease. Long-term, high-dose glucocorticoid therapy can be used to treat the disease, but the fact that the drug distributes systemically can give rise to severe adverse effects. Here we develop a targeted system for treating RA in which the glucocorticoid prednisolone (PD) is encapsulated within solid lipid nanoparticles (SLNs) coated with hyaluronic acid (HA), giving rise to HA-SLNs/PD. HA binds to hyaluronic receptor CD44, which is over-expressed on the surface of synovial lymphocytes, macrophages and fibroblasts in inflamed joints in RA...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29496227/efficacy-and-safety-of-repeated-courses-of-hyaluronic-acid-injections-for-knee-osteoarthritis-a-systematic-review
#12
REVIEW
Roy Altman, Josh Hackel, Faizan Niazi, Peter Shaw, Mathew Nicholls
INTRODUCTION: Hyaluronic acid (HA) is a commonly prescribed intra-articular (IA) therapy for knee osteoarthritis (OA). While a single series of IA-HA has been well studied, the efficacy and safety of repeated courses of IA-HA injection therapy in knee OA patients have not been evaluated as frequently. METHODS: A literature search was conducted using MEDLINE, EMBASE and PubMed databases. The primary outcome measure was knee pain reduction after each treatment course and/or last reported follow-up visit...
January 31, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29490683/exploring-determinants-predicting-response-to-intra-articular-hyaluronic-acid-treatment-in-symptomatic-knee-osteoarthritis-9-year-follow-up-data-from-the-osteoarthritis-initiative
#13
Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme, Johanne Martel-Pelletier
BACKGROUND: The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulness of intra-articular hyaluronic acid (IAHA) injections for the symptomatic treatment of knee osteoarthritis (OA). Among the reasons for the controversy is that the current literature provides inconsistent results and conclusions about such treatment. This study aimed at identifying determinants associated with a better response to IAHA treatment in knee OA...
March 1, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29490116/supplementation-of-specific-carbohydrates-results-in-enhanced-deposition-of-chondrogenic-specific-matrix-during-mesenchymal-stem-cell-differentiation
#14
Trudy Christiansen-Weber, Alexander Noskov, Dylan Cardiff, Ibon Garitaonandia, Alexa Dillberger, Andrey Semechkin, Rodolfo Gonzalez, Russell Kern
Repair or regeneration of hyaline cartilage in knees, shoulders, intervertebral discs and other assorted joints is a major therapeutic target. To date, therapeutic strategies utilizing chondrocytes or mesenchymal stem cells are limited by expandability or the generation of mechanically inferior cartilage. Our objective is to generate robust cartilage-specific matrix from human mesenchymal stem cells suitable for further therapeutic development. Human mesenchymal stem cells, in an alginate 3D format, were supplied with individual sugars and chains which comprise the glycan component of proteoglycans in articular cartilage (galactose, hyaluronic acid, glucuronic acid and xylose) during chondrogenesis...
February 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29464283/-osteoarthritis-of-the-shoulder-pathogenesis-diagnostics-and-conservative-treatment-options
#15
REVIEW
J Mehl, A B Imhoff, K Beitzel
PATHOGENESIS: Osteoarthritis of the shoulder is characterized by a progressive degenerative process, which is based on chronic inflammation with intra-articular release of different cytokines and proteolytic enzymes. The main predisposing factors are a history of trauma or surgery, as well as chronic overuse or instability of the glenohumeral joint. Affected patients especially suffer from impaired joint function and pain, which are often associated with cognitive and psychosocial restrictions...
February 20, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29429372/anti-inflammatory-effects-of-intra-articular-hyaluronic-acid-a-systematic-review
#16
Roy Altman, Asheesh Bedi, Ajay Manjoo, Faizan Niazi, Peter Shaw, Philip Mease
Objective Osteoarthritis (OA) is one of the leading causes of disability in the adult population. Common nonoperative treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, and intra-articular injections of hyaluronic acid (HA). HA is found intrinsically within the knee joint providing viscoelastic properties to the synovial fluid. HA therapy provides anti-inflammatory relief through a number of different pathways, including the suppression of pro-inflammatory cytokines and chemokines...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29396701/cartilage-turnover-and-intra-articular-corticosteroid-injections-in-knee-osteoarthritis
#17
Rainer Klocke, Kirsty Levasseur, George D Kitas, Jacqueline P Smith, George Hirsch
Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine...
February 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29389685/cost-effectiveness-of-different-intra-articular-drug-injections-on-wrist-and-or-elbow-compromise-in-patients-with-established-rheumatoid-arthritis-short-term-results-of-an-open-observational-evaluation
#18
Zhi Qin Li, Zhao Hui Zheng, Lin Xuan Pang, Jin Ding, Wang Lei Du, Xue Yi Li, Peng Zhao, Nan Leng, Zhen Biao Wu, Ping Zhu
BACKGROUND: Intra-articular (IA) injections are an integral part of the management of rheumatoid arthritis (RA). However, there are few reports regarding the association between drug effectiveness and cost. OBJECTIVES: The aim of this study was to assess the cost-effectiveness of various combinations of IA injections of betamethasone, hyaluronic acid (HA) or etanercept for oligoarthritis in RA. METHODS: Seventy RA patients were assigned to 4 groups according to the IA injection drug(s): betamethasone alone, betamethasone + etanercept, betamethasone + HA, or etanercept alone...
February 1, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29388085/comparison-of-hyaluronic-acid-and-prp-intra-articular-injection-with-combined-intra-articular-and-intraosseous-prp-injections-to-treat-patients-with-knee-osteoarthritis
#19
Ke Su, Yuming Bai, Jun Wang, Haisen Zhang, Hao Liu, Shiyun Ma
The aim of this study was to evaluate the benefit provided by intraosseous infiltration combined with intra-articular injection of platelet-rich plasma to treat mild and moderate stages of knee joint degeneration (Kellgren-Lawrence score II-III) compared with other treatments, specifically intra-articular injection of PRP and of HA. Eighty-six patients with grade II to grade III knee OA according to the Kellgren-Lawrence classification were randomly assigned to intra-articular combined with intraosseous injection of PRP (group A), intra-articular PRP (group B), or intra-articular HA (group C)...
January 31, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29385029/comparison-of-compressive-stress-relaxation-behavior-in-osteoarthritic-icrs-graded-human-articular-cartilage
#20
Rajesh Kumar, David M Pierce, Vidar Isaksen, Catharina de Lange Davies, Jon O Drogset, Magnus B Lilledahl
Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular cartilage in clinically defined osteoarthritic stages may have importance in diagnosis and prognosis of OA. In this study we investigated differences in the biomechanical responses among human cartilage of ICRS grades I, II and III using polymer dynamics theory. We collected 24 explants of human articular cartilage (eight each of ICRS grade I, II and III) and acquired stress-relaxation data applying a continuous load on the articular surface of each cartilage explant for 1180 s...
January 31, 2018: International Journal of Molecular Sciences
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