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Hyaluronic acid joint

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https://www.readbyqxmd.com/read/28100866/development-of-intra-knee-joint-sustained-release-gel-formulation-and-evaluation-of-its-pharmacological-efficiency-in-rats
#1
Takehiro Noda, Tomoyuki Okuda, Kousuke Ban, Ryota Mizuno, Tatsuaki Tagami, Tetsuya Ozeki, Hirokazu Okamoto
In the development of a drug for intra-articular administration, a sustained-release formulation is desirable since it is difficult to sustain the effects of conventional injections due to fast drug leakage from the joint cavity. In this study, we prepared sustained release gel formulations for intra-articular administration containing indocyanine green (ICG) as a model drug to follow its fate after intra-articular administration in rats with IVIS. ICG administered as an aqueous solution leaked from the joint cavity in a short time and was excreted out of the body within a day...
January 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28066733/viscosupplementation-with-intra-articular-hyaluronic-acid-for-hip-disorders-a-systematic-review-and-meta-analysis
#2
Eleonora Piccirilli, Francesco Oliva, Mihaela Aconstantinesei Murè, Asmaa Mahmoud, Calogero Foti, Umberto Tarantino, Nicola Maffulli
BACKGROUND: Hip joint diseases are common in adult population and their prevalence increases with age. Osteoarthritis, rheumatoid arthritis and femoroacetabular impingement are the most common chronic diseases in the hip joint. Viscosupplementation with exogenous hyaluronic acid (HA) is one of the most widely used conservative treatment aiming to improve synovial fluid properties and to decrease pain. There is no global consensus on the type of HA, method of injection and frequency, or on its efficacy in hip joint...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28058962/short-term-effect-of-ultrasound-guided-low-molecular-weight-hyaluronic-acid-injection-on-clinical-outcomes-and-imaging-changes-in-patients-with-rheumatoid-arthritis-of-the-ankle-and-foot-joints-a-randomized-controlled-pilot-trial
#3
Chien-Chih Wang, Si-Huei Lee, Hsiao-Yi Lin, Fu-Wei Liu, Hong-Jen Chiou, Rai-Chi Chan, Chen-Liang Chou
To determine whether hyaluronic acid (HA) injection into rheumatoid arthritis ankles and feet can achieve improvement in foot function and reduce synovial hyper-vascularization. Forty-four patients with RA having unilateral or bilateral painful ankle and foot involvement (N = 75) were studied. All the patients were randomized to receive HA (N = 40) or lidocaine (LI) (N = 35) injection at 2-week intervals; Clinical assessments were performed using a visual analog scale (VAS) and foot function index (FFItotal) including subscales of pain (FFIpain) before injection at baseline, 4 weeks (first evaluation) and 12 weeks (secondary evaluation)...
January 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28056915/predictors-of-response-to-viscosupplementation-in-patients-with-hip-osteoarthritis-results-of-a-prospective-observational-multicentre-open-label-pilot-study
#4
Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier, Thierry Conrozier
BACKGROUND: To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA). METHODS: Prospective, multicentre, open-label trial, achieved in daily practice conditions. Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol (HAnox-M-XL), using imaging guidance. WOMAC pain and function scores and patient global assessment (PGA) were assessed at baseline and day 90...
January 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28054366/the-role-of-molecular-pain-biomarkers-in-temporomandibular-joint-internal-derangement
#5
REVIEW
Malin Ernberg
There is evidence that low-grade inflammation may be responsible for pain and development of degenerative changes in temporomandibular joint internal derangement. This article reviews the current knowledge of the molecular mechanisms behind TMJ internal derangements. A non-systematic search was carried out in PubMed, Embase, and the Cochrane library for studies regarding pathophysiological mechanisms behind internal derangements focusing on pain mediating inflammatory and cartilage degrading molecules. Recent data suggests that release of cytokines may be the key event for pain and cartilage destruction in TMJ internal derangements...
January 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28002900/pain-reduction-and-improvement-of-function-following-ultrasound-guided-intra-articular-injections-of-triamcinolone-hexacetonide-and-hyaluronic-acid-in-hip-osteoarthritis
#6
J P Araújo, L Silva, R Andrade, M Paços, H Moreira, N Migueis, R Pereira, A Sarmento, H Pereira, N Loureiro, J Espregueira-Mendes
The scientific literature has shown positive results regarding intra-articular injections of hyaluronic acid in osteoarthritic joints. When injecting in the hip joint, the guidance of ultrasound can provide higher injection accuracy and repeatability. However, due to the methodological limitations in the current available literature, its recommendation in the current practice is still controversial. This study shows that ultrasound-guided intra-articular injections of triamcinolone hexacetonide and hyaluronic acid can improve pain, function and quality of life in patients with symptomatic and radiographic hip osteoarthritis...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28002895/hybrid-complexes-of-high-and-low-molecular-weight-evaluation-using-an-in-vitro-model-of-osteoarthritis
#7
A Stellavato, F De Novellis, S Reale, M De Rosa, C Schiraldi
Hyaluronan (HA) is central in joint and cartilage functions and to restore synovial fluid viscosity. In patients with osteoarthritis (OA), molecular weight (MW) and concentration of hyaluronic acid (HA) are reduced, diminishing joint lubrication. IL-1β treatment was used to mimic osteoarthritis in a chondrocytes based in vitro model. The aim of our research, using this model and human chondrocytes was to assess the anti-inflammatory effect of H/L-HA hybrid complexes (SINOVIAL-HL®) in comparison with HA at high (H-HA) and low molecular weight (L-HA) separately used, through the evaluation of specific biomarkers involved in cartilage degradation and correlated to osteoarthritis...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27993154/efficacy-and-safety-of-adult-human-bone-marrow-derived-cultured-pooled-allogeneic-mesenchymal-stromal-cells-stempeucel%C3%A2-preclinical-and-clinical-trial-in-osteoarthritis-of-the-knee-joint
#8
Pawan Kumar Gupta, Anoop Chullikana, Mathiyazhagan Rengasamy, Naresh Shetty, Vivek Pandey, Vikas Agarwal, Shrikant Yeshwant Wagh, Prasanth Kulapurathu Vellotare, Devi Damodaran, Pachaiyappan Viswanathan, Charan Thej, Sudha Balasubramanian, Anish Sen Majumdar
BACKGROUND: Osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the joints. Currently, cell-based therapy is being explored to address the repair of damaged articular cartilage in the knee joint. METHODS: The in vitro differentiation potential of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®) was determined by differentiating the cells toward the chondrogenic lineage and quantifying sulfated glycosaminoglycan (sGAG)...
December 20, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27982753/flexpro-md-a-mixture-of-krill-oil-astaxanthin-and-hyaluronic-acid-suppresses-lipopolysaccharide-induced-inflammatory-cytokine-production-through-inhibition-of-nf-%C3%AE%C2%BAb
#9
Doo Ri Park, Ryeojin Ko, Suk Hyung Kwon, Bokkee Min, Seong Ho Yun, Manh Heun Kim, John Minatelli, Stephen Hill, Soo Young Lee
FlexPro MD(®) (FP-MD), a novel multi-ingredient dietary supplement formulation, has been demonstrated to relieve knee joint pain in humans. However, the mechanisms of action responsible for the activity of FP-MD have not been elucidated. In this study, we show the anti-inflammatory effects of FP-MD in RAW264.7 macrophage cells and mice challenged with lipopolysaccharide (LPS). FP-MD significantly inhibited the mRNA levels of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-1β...
December 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27973762/intra-articular-injections-of-hyadd4-g-in-male-professional-soccer-players-with-traumatic-or-degenerative-knee-chondropathy-a-pilot-prospective-study
#10
Pasquale Tamburrino, Enrico Castellacci
BACKGROUND: Knee injuries are very common in some sports and particularly in soccer due to the highly repetitive loading of the mechanical stress involved in this practice. Knee-joint injuries account for 40% of all different kinds of lesions. Traumatic or degenerative patellofemoral or tibialfemoral chondropaties of knee cause disabling symptoms, joint pain and/or dysfunctions. The aim of the study was to evaluate the effects of HYADD4-G, a hydrogel based on a hyaluronic acid derivative, in professional soccer players affected by traumatic or degenerative knee chondropathy...
December 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27973684/the-impact-of-arthrocentesis-with-and-without-hyaluronic-acid-injection-in-the-prognosis-and-synovial-fluid-myeloperoxidase-levels-of-patients-with-painful-symptomatic-internal-derangement-of-temporomandibular-joint-a-randomized-controlled-clinical-trial
#11
Serap Moroğlu Ozdamar, Burcin Alev, Aysen Yarat
BACKGROUND: We aimed to assess the relationship between myeloperoxidase (MPO) and internal derangement (ID) of temporomandibular joint (TMJ) and effects of arthrocentesis procedure, either alone or in combination with hyaluronic acid (HA) injection on the prognosis of ID of TMJ. METHODS: A prospective randomized controlled trial has been conducted through patients, who underwent arthrocentesis for the treatment of ID of TMJ, were randomly divided into two groups...
December 14, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27960136/polyethylene-oxide-peo-hyaluronic-acid-ha-nanofibers-with-kanamycin-inhibits-the-growth-of-listeria-monocytogenes
#12
J J Ahire, D D Robertson, A J van Reenen, L M T Dicks
Listeria monocytogenes is well known to cause prosthetic joint infections in immunocompromised patients. In this study, polyethylene oxide (PEO) nanofibers, containing kanamycin and hyaluronic acid (HA), were prepared by electrospinning at a constant electric field of 10kV. PEO nanofibers spun with 0.2% (w/v) HA and 1% (w/v) kanamycin had a smooth, bead-free structure at 30-35% relative humidity. The average diameter of the nanofibers was 83±20nm. Attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy indicated that kanamycin was successfully incorporated into PEO/HA matrix...
December 10, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27955699/adelmidrol-in-combination-with-hyaluronic-acid-displays-increased-anti-inflammatory-and-analgesic-effects-against-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#13
Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri, Marika Cordaro, Domenico Britti, Valeria Maria Morittu, Maurizio Evangelista, Salvatore Cuzzocrea
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease produced by a cascade of events that can ultimately lead to joint damage. The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis. METHODS: OA was induced by intra-articular injection of MIA in the knee joint...
December 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27920810/hyaluronic-acid-in-the-management-of-osteoarthritis-injection-therapies-innovations
#14
Valter Santilli, Marco Paoloni, Massimiliano Mangone, Federica Alviti, Andrea Bernetti
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular (IA) hyaluronic acid (HA) could be a treatment option in OA, however recommendations made in different international guidelines for the non-surgical management of OA are not always concordant with regard to the role of IA injection therapies. Results from a recent Italian Consensus Conference underline how IA-HA to treat OA represents a widely used therapy in Italy...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27920709/shoulder-pain-after-fall-septic-shock-and-pyomyositis-associated-with-breast-cancer-chemotherapy-and-lymphedema
#15
Hiromitsu Kitayama, Junko Sugiyama, Michiaki Hirayama, Yosihiro Onada, Yasushi Tsuji
BACKGROUND: As a symptom of pyomyositis, sepsis usually follows local inflammation signs. Here, we report pyomyositis with lymphedema of upper extremity in which septic shock and poor local findings initially presented during chemotherapy for breast cancer. CASE REPORT: An 80-year-old woman presented with chronic right shoulder pain during chemotherapy for the recurrent disease. She had a history of postmastectomy lymphedema, diabetes mellitus, and repeated hyaluronic acid injections to the shoulder joint...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27905661/artificial-cartilage-bio-matrix-formed-of-hyaluronic-acid-and-mg2-polyphosphate
#16
X Wang, M Ackermann, E Tolba, M Neufurth, F Wurm, Q Feng, S Wang, H C Schröder, W E Müller
Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP...
November 29, 2016: European Cells & Materials
https://www.readbyqxmd.com/read/27895468/increased-localized-delivery-of-piroxicam-by-cationic-nanoparticles-after-intra-articular-injection
#17
Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang
Piroxicam (PRX), a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP) was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA) injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA) in the synovial cavity...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27895439/comparison-of-two-different-molecular-weight-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#18
I Gigis, E Fotiadis, A Nenopoulos, K Tsitas, I Hatzokos
BACKGROUND: Knee osteoarthritis (OA) is an incurable joint disorder, representing a major public health issue. Among options for symptom control, viscosupplementation with hyaluronic acid (HA) had established usefulness in pain and function improvement of the knee. However, it is not clear which form of HA yields better results. MATERIAL AND METHODS: We compared two HA preparations with high (HMW) or low molecular weight (LMW) in terms of pain control and function improvement using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the visual analog scale (VAS) score in patients with knee OA...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27881922/effectiveness-of-etofenamate-for-treatment-of-knee-osteoarthritis-a-randomized-controlled-trial
#19
Savaş Güner, Mehmet Ata Gökalp, Abdurrahim Gözen, Seyyid Şerif Ünsal, Şükriye İlkay Güner
The intramuscular application of etofenamate in the treatment of knee osteoarthritis was not observed in the existing English language literature. The objectives of this study were to compare the efficacy of etofenamate versus hyaluronic acid (HA) in reducing joint pain and functional improvement for mild to moderate knee osteoarthritis. The patients were randomly divided into etofenamate (n=29) and HA (n=30) groups. Intramuscular etofenamate injection was administered as a series of seven intramuscular injections at intervals of 1 day...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27847713/effect-of-intra-articular-hyaluronic-acid-injection-on-hemiplegic-shoulder-pain-after-stroke
#20
Myung Hun Jang, Chang-Hyung Lee, Yong-Il Shin, Soo-Yeon Kim, Sung Chul Huh
OBJECTIVE: To evaluate the efficacy of intra-articular hyaluronic acid (IAHA) injection for hemiplegic shoulder pain (HSP) after stroke. METHODS: Thirty-one patients with HSP and limited range of motion (ROM) without spasticity of upper extremity were recruited. All subjects were randomly allocated to group A (n=15) for three weekly IAHA injection or group B (n=16) for a single intra-articular steroid (IAS) injection. All injections were administered by an expert physician until the 8th week using a posterior ultrasonography-guided approach...
October 2016: Annals of Rehabilitation Medicine
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