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https://www.readbyqxmd.com/read/29464283/-osteoarthritis-of-the-shoulder-pathogenesis-diagnostics-and-conservative-treatment-options
#1
REVIEW
J Mehl, A B Imhoff, K Beitzel
PATHOGENESIS: Osteoarthritis of the shoulder is characterized by a progressive degenerative process, which is based on chronic inflammation with intra-articular release of different cytokines and proteolytic enzymes. The main predisposing factors are a history of trauma or surgery, as well as chronic overuse or instability of the glenohumeral joint. Affected patients especially suffer from impaired joint function and pain, which are often associated with cognitive and psychosocial restrictions...
February 20, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29429372/anti-inflammatory-effects-of-intra-articular-hyaluronic-acid-a-systematic-review
#2
Roy Altman, Asheesh Bedi, Ajay Manjoo, Faizan Niazi, Peter Shaw, Philip Mease
Objective Osteoarthritis (OA) is one of the leading causes of disability in the adult population. Common nonoperative treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, and intra-articular injections of hyaluronic acid (HA). HA is found intrinsically within the knee joint providing viscoelastic properties to the synovial fluid. HA therapy provides anti-inflammatory relief through a number of different pathways, including the suppression of pro-inflammatory cytokines and chemokines...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29396701/cartilage-turnover-and-intra-articular-corticosteroid-injections-in-knee-osteoarthritis
#3
Rainer Klocke, Kirsty Levasseur, George D Kitas, Jacqueline P Smith, George Hirsch
Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine...
February 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29389685/cost-effectiveness-of-different-intra-articular-drug-injections-on-wrist-and-or-elbow-compromise-in-patients-with-established-rheumatoid-arthritis-short-term-results-of-an-open-observational-evaluation
#4
Zhi Qin Li, Zhao Hui Zheng, Lin Xuan Pang, Jin Ding, Wang Lei Du, Xue Yi Li, Peng Zhao, Nan Leng, Zhen Biao Wu, Ping Zhu
BACKGROUND: Intra-articular (IA) injections are an integral part of the management of rheumatoid arthritis (RA). However, there are few reports regarding the association between drug effectiveness and cost. OBJECTIVES: The aim of this study was to assess the cost-effectiveness of various combinations of IA injections of betamethasone, hyaluronic acid (HA) or etanercept for oligoarthritis in RA. METHODS: Seventy RA patients were assigned to 4 groups according to the IA injection drug(s): betamethasone alone, betamethasone + etanercept, betamethasone + HA, or etanercept alone...
February 1, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29388085/comparison-of-hyaluronic-acid-and-prp-intra-articular-injection-with-combined-intra-articular-and-intraosseous-prp-injections-to-treat-patients-with-knee-osteoarthritis
#5
Ke Su, Yuming Bai, Jun Wang, Haisen Zhang, Hao Liu, Shiyun Ma
The aim of this study was to evaluate the benefit provided by intraosseous infiltration combined with intra-articular injection of platelet-rich plasma to treat mild and moderate stages of knee joint degeneration (Kellgren-Lawrence score II-III) compared with other treatments, specifically intra-articular injection of PRP and of HA. Eighty-six patients with grade II to grade III knee OA according to the Kellgren-Lawrence classification were randomly assigned to intra-articular combined with intraosseous injection of PRP (group A), intra-articular PRP (group B), or intra-articular HA (group C)...
January 31, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29385029/comparison-of-compressive-stress-relaxation-behavior-in-osteoarthritic-icrs-graded-human-articular-cartilage
#6
Rajesh Kumar, David M Pierce, Vidar Isaksen, Catharina de Lange Davies, Jon O Drogset, Magnus B Lilledahl
Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular cartilage in clinically defined osteoarthritic stages may have importance in diagnosis and prognosis of OA. In this study we investigated differences in the biomechanical responses among human cartilage of ICRS grades I, II and III using polymer dynamics theory. We collected 24 explants of human articular cartilage (eight each of ICRS grade I, II and III) and acquired stress-relaxation data applying a continuous load on the articular surface of each cartilage explant for 1180 s...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29379312/intra-articular-ozone-or-hyaluronic-acid-injection-which-one-is-superior-in-patients-with-knee-osteoarthritis-a-6-month-randomized-clinical-trial
#7
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Bijan Forogh, Porya Hassan Abadi, Mahsa Moridnia, Shahram Rahimi Dehgolan
Purpose: Knee osteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased function. There are many therapeutic modalities including non-pharmacologic choices and oral, topical, and intra-articular medications. New studies have shown promising results for ozone application in knee OA. Our aim was to compare the effects of ozone therapy versus hyaluronic acid (HA) intra-articular injection in knee OA patients. Methods: In this randomized clinical trial, a total of 174 patients with more than 3 months of chronic pain or swelling in the knee joints along with consistent imaging findings were enrolled and randomly allocated into two groups of HA and ozone, which were planned to undergo 3 weekly injections of HA (Hyalgan®) and 10 mL of a 30 μg/mL ozone solution, respectively...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29318429/effect-of-intra-articular-injection-of-intermediate-weight-hyaluronic-acid-on-hip-and-knee-cartilage-in-vivo-evaluation-using-t2-mapping
#8
Giulio Ferrero, Luca Maria Sconfienza, Francesco Fiz, Emanuele Fabbro, Angelo Corazza, Daniele Dettore, Davide Orlandi, Carlo Castellazzo, Stefano Tornago, Giovanni Serafini
OBJECTIVES: We used T2 mapping to quantify the effect of intra-articular hyaluronic acid administration (IAHAA) on cartilage with correlation to clinical symptoms. METHODS: One hundred two patients with clinical and MRI diagnosis of hip or knee grade I-III chondropathy were prospectively included. All patients received a standard MRI examination of the affected hip/knee (one joint/patient) and T2-mapping multiecho sequence for cartilage evaluation. T2 values of all slices were averaged and used for analysis...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29261165/anomalous-behavior-of-hyaluronan-crosslinking-due-to-the-presence-of-excess-phospholipids-in-the-articular-cartilage-system-of-osteoarthritis
#9
Piotr Bełdowski, Piotr Weber, Tomasz Andrysiak, Wayne K Augé Ii, Damian Ledziński, Tristan De Leon, Adam Gadomski
Lubrication of articular cartilage is a complex multiscale phenomenon in synovial joint organ systems. In these systems, synovial fluid properties result from synergistic interactions between a variety of molecular constituent. Two molecular classes in particular are of importance in understanding lubrication mechanisms: hyaluronic acid and phospholipids. The purpose of this study is to evaluate interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions...
December 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29245352/effect-of-multiple-intra-articular-injections-of-polynucleotides-on-treatment-of-intractable-knee-osteoarthritis-a-case-report
#10
Jong-Uk Mun, Hyung Rae Cho, Young Soon Choi, Young Uk Kim
RATIONALE: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all. Polynucleotides (PN) are recently noted as a valid substitute for HA. PATIENT CONCERNS: A 61-year-old female was admitted to the pain center with symptoms of pain over the knee and warmth feeling with stiffness in the left knee. The patient reported chronic severe pain in the left knee area despite 6 times IAI of HA...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#11
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29208903/a-novel-bioreactor-system-for-biaxial-mechanical-loading-enhances-the-properties-of-tissue-engineered-human-cartilage
#12
Christoph Meinert, Karsten Schrobback, Dietmar W Hutmacher, Travis J Klein
The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes associated with tissue-engineered implants are still limiting their application. To improve clinical outcomes and facilitate a wider use of engineered tissues, automated bioreactor systems capable of enhancing and monitoring neotissues are required. Here, we developed an innovative system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and automated fashion...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29202567/the-use-of-hyaluronic-acid-in-the-treatment-of-ankle-osteoarthritis-a-review-of-the-evidence
#13
R Papalia, E Albo, F Russo, A Tecame, G Torre, S Sterzi, F Bressi, V Denaro
Ankle osteoarthritis (OA) is a progressive degenerative joint disease that causes ankle pain and functional limitation especially during walking. It tends to involve younger people with high functional request and has often a post-traumatic origin. Symptoms control through conservative treatment is essential to procrastinate as long as possible the need for surgery. Although few data are present in literature about the use of local viscosupplementation in ankle OA, their potential use for ankle OA has been suggested...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202562/intrarticular-injections-of-hyaluronic-acid-for-trapezio-metacarpal-osteoarthritis-a-systematic-review
#14
R Papalia, L A Diaz, G Torre, E Albo, A Tecame, S Sterzi, F Bressi, V Denaro
Osteoarthritis (OA) of the base of the thumb, also known as Trapezio-Metacarpal (TM) OA, is a disabling condition, which mainly affects women and manual workers. When TM OA is not adequately treated, patients develop deformity and loss of function of the thumb. The surgical approach is a widespread strategy to treat this condition, but there is still no consensus on the most effective procedure. Therefore, several conservative strategies are commonly used, such as nonsteroidal anti-inflammatory drugs (NSAIDs) administration, thumb strengthening exercise, splinting, steroid (CS) and hyaluronic acid (HA) intrarticular injections...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202561/meniscal-extrusion-as-booster-of-osteoarthritis
#15
R Papalia, G Papalia, F Russo, L A Diaz, F Bressi, S Sterzi, V Denaro
Meniscal extrusion (ME) has shown to play a critical but still unclear role in osteoarthritis (OA) development. ME has been described as an important risk factor in the progression of knee OA, as it is involved in the thinning of articular cartilage, joint space narrowing, spontaneous osteonecrosis of the knee and subchondral bone marrow lesions. Meniscal damage of any degree of severity could cause ME in both compartments, but it is commonly associated with severe meniscal tears or root tears mainly in the medial meniscus...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202560/the-use-of-hyaluronic-acid-in-the-treatment-of-shoulder-capsulitis-a-systematic-review
#16
R Papalia, A Tecame, G Vadalà, F Russo, M Perna, G Papalia, F Bressi, S Sterzi, V Denaro
Adhesive capsulitis (AC) is a common pathological condition of the shoulder characterized by painful restriction of range of motion (ROM) of the glenohumeral joint. Currently, no consensus has been reached regarding the best treatment. Hyaluronic acid (HA) injection is a safe procedure that can result in significant improvement in active and passive ROM, alleviating pain and improving shoulder function. We systematically reviewed current literature in order to evaluate the best evidence about the effectiveness of intra-articular HA injection for the treatment of primary AC...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29186947/one-step-cartilage-repair-with-minced-chondral-fragment-on-a-composite-scaffold-an-in-vitro-human-study-at-low-oxygen-tension
#17
A G Marmotti, G M Peretti, S Mattia, L Mangiavini, D E Bonasia, F Dettoni, E Bellato, S Schwienbacher, F Castoldi
Minced cartilage fragments are a viable cell source for one stage cartilage repair. However, the joint surface is a low oxygen tension microenvironment and little evidence is present in literature regarding the behaviour of cartilage fragments in this peculiar condition. The aim of the study is i) to verify if low oxygen tension could negatively influence chondrocyte outgrowth from cartilage fragments into a Hyaluronic-Acid(HA)/fibrin scaffold and ii) to evaluate its effects on the behaviour of migrating chondrocyte, compared to normoxic condition...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29166937/a-putative-chondroprotective-role-for-il-1%C3%AE-and-mpo-in-herbal-treatment-of-experimental-osteoarthritis
#18
Nora M Aborehab, Mahitab H El Bishbishy, Abeer Refaiy, Nermien E Waly
BACKGROUND: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. METHODS: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400 mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1β) and superoxide dismutase activity (SOD) were measured using ELISA...
November 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29132341/can-hybrid-hyaluronic-acid-represent-a-valid-approach-to-treat-rizoarthrosis-a-retrospective-comparative-study
#19
Sara Tenti, Nicola Antonio Pascarelli, Stefano Giannotti, Mauro Galeazzi, Nicola Giordano, Antonella Fioravanti
BACKGROUND: Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological and pharmacological treatments that include intra-articular (i.a.) therapy. EULAR experts recommend corticosteroid injections in TMJ OA and underline the usefulness of hyaluronic acid (HA). The aim of this study was the assessment of the efficacy and tolerability of i...
November 13, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29130677/-dermoscopy-study-on-the-effects-of-gold-microacupuncture-hyaluronic-acid-injection-and-rb-bfgf-to-treat-facial-rejuvenation
#20
Ge Su, Xun Zhou
OBJECTIVE: To explore the dermoscopic changes facial rejuvenation after the combination therapy of gold microacupuncture,Hyaluronic acid (HA) injection,and recombinant bovine alkaline fibroblast growth factor (rbbFGF). METHODS: Twenty cases of patients (age from 30 to 55 yearold) with facial skin naturally aging were included. The patients received multisource radio frequency therapeutic apparatus for injection at the subbermaldermal levels from 1316 W. Noncrosslinking HA of 2 mL was injected in the upper dermis...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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