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https://www.readbyqxmd.com/read/28796122/ocular-surface-lubricants
#1
Leonard Bielory, Preeti Wagle
PURPOSE OF REVIEW: The purpose of this article is to provide an overview of the ocular lubricants currently available, consider the components of the various formulations and highlight the status of preservative use in the treatment of anterior ocular surface diseases. RECENT FINDINGS: The primary components of ocular surface lubrication have been, in the past, based on various cellulose formulations that increase hydration. Advances in lubrication have come from areas of the human body requiring lubrication such as the skeletal joints as well as examining the use of natural components of the tear fluid...
August 8, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28768880/hyaluronan-supplementation-as-a-mechanical-regulator-of-cartilage-tissue-development-under-joint-kinematic-mimicking-loading
#2
Yabin Wu, Martin J Stoddart, Karin Wuertz-Kozak, Sibylle Grad, Mauro Alini, Stephen J Ferguson
Articular cartilage plays an essential role in joint lubrication and impact absorption. Through this, the mechanical signals are coupled to the tissue's physiological response. Healthy synovial fluid has been shown to reduce and homogenize the shear stress acting on the cartilage surfaces due to its unique shear-thinning viscosity. As cartilage tissues are sensitive to mechanical changes in articulation, it was hypothesized that replacing the traditional culture medium with a healthy non-Newtonian lubricant could enhance tissue development in a cartilage engineering model, where joint-kinematic-mimicking mechanical loading is applied...
August 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28761275/efficacy-of-arthrocentesis-versus-arthrocentesis-with-sodium-hyaluronic-acid-in-temporomandibular-joint-osteoarthritis-a-comparison
#3
Tikaram Gurung, R K Singh, Shadab Mohammad, U S Pal, Abbas Ali Mahdi, Manoj Kumar
INTRODUCTION: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease characterized by deterioration of articular tissue with concomitant osseous changes in the condyle and/or articular eminence, joint positive for TMJ noise with jaw movement or function, crepitus detected on palpation on opening, closing, right/left lateral, or protrusive movement. Hyaluronic acid (HA) is a polysaccharide of the family of glycosaminoglycans. HA has been shown to improve and restore normal lubrication in joint, provide nutrition to the avascular articulating disc, and stabilize the joint...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28731959/efficacy-of-intra-articular-botulinum-toxin-in-osteo-articular-joint-pain-a-meta-analysis-of-randomized-controlled-trials
#4
Mathilde Courseau, Pascale Vergne Salle, Danièle Ranoux, Anais de Pouilly Lachatre
OBJECTIVE: To evaluate the efficacy of intra-articular injections of botulinum toxin A (BT-A) into the painful joint diseases through a systematic review of the literature and a meta-analysis of controlled randomized trials. Indeed, intra articular therapies (corticosteroids, hyaluronic acid) have limited efficacy and run a risk of toxicity in patients with joint pain. New therapeutic options are needed to treat painful osteo-articular disease. METHODS: We searched via Pubmed, ACR and EULAR congresses and grey literature for the studies reported until June 2016 and addressing the issue of BT intra articular injections in patients with refractory joint pain...
July 20, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28728606/levels-of-serum-biomarkers-from-a-two-year-multicentre-trial-are-associated-with-treatment-response-on-knee-osteoarthritis-cartilage-loss-as-assessed-by-magnetic-resonance-imaging-an-exploratory-study
#5
Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some serum biomarkers to be associated with a better response to chondroitin sulfate in reducing cartilage volume loss. METHODS: Eight biomarkers were studied: hyaluronic acid (HA), C reactive protein (CRP), adipsin, leptin, N-terminal propeptide of collagen IIα (PIIANP), C-terminal crosslinked telopeptide of type I collagen (CTX-1), matrix metalloproteinase-1 (MMP-1), and MMP-3...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28708631/development-of-systemic-inflammatory-polyarthritis-after-zygapophyseal-joint-injection-with-hylan-g-f-20-synvisc-one
#6
Denizen Kocak, Thiru Annaswamy, Sharon Chong, Rashmi Arora
Hylan G-F 20 (Synvisc-One) is a hyaluronic acid derivative used for viscosupplementation of synovial fluid in osteoarthritic joints. Injection of hylan G-F 20 is Federal Drug Administration approved for use in knee osteoarthritis and is generally well tolerated with few reported adverse effects, the most common being local pain or swelling. We present the case of a 72-year-old man with bilateral, diffuse, joint pain and swelling with elevated inflammatory markers suggestive of a systemic inflammatory polyarthropathy that developed acutely 2 days after lumbar zygapophyseal joint injection with hylan G-F 20...
July 13, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28699498/is-the-addition-of-a-polyol-to-hyaluronic-acid-a-significant-advance-in-the-treatment-of-osteoarthritis
#7
Thierry Conrozier
Viscosupplementation with intra-articular injections of hyaluronic acid is recommended as a second line treatment for knee OA, after failure of non-pharmacological modalities and usual pain killers. Nevertheless there is still controversies regarding clinical relevance of its effects. Research is looking at the best means to improve the performance of viscosupplementation in order to obtain a faster, more sustainable and more marked effect. Antioxidants have been assessed in combination with hyaluronic acid because the injected hyaluronate is rapidly degraded by the reactive oxygen species present in large amounts in the OA synovial fluid, limiting its residence time into the joint...
July 10, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28669720/ultra-low-friction-between-boundary-layers-of-hyaluronan-phosphatidylcholine-complexes
#8
Linyi Zhu, Jasmine Seror, Anthony J Day, Nir Kampf, Jacob Klein
The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfaces bearing attached hyaluronan (hyaluronic acid, or HA) to which different phosphatidylcholine (PC) lipids had been added, in the form of small unilamellar vesicles (SUVs or liposomes), using a surface force balance, to shed light on possible cartilage boundary lubrication by such complexes...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28593930/intra-articular-injections-of-ketamine-and-25-dextrose-improve-clinical-and-pathological-outcomes-in-the-monosodium-iodoacetate-model-of-osteoarthritis
#9
Yashashri C Shetty, Amol E Patil, Sharmila V Jalgaonkar, Nirmala N Rege, Sweta Salgaonkar, Prachi A Teltumbde, Sagar Kshirsagar, Paresh G Koli, Smita Brahma
BACKGROUND: The study evaluated the effect of intra-articular injections of ketamine and 25% dextrose with triamcinolone acetate (TA) and hyaluronic acid (HA) on joint pathology and pain behavior in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in experimental mice. METHODS: In phase I, the MIA-induced OA model was standardized. In phase II, mice were divided into three groups: disease controls (DC), ketamine 12 mg/kg (K12) and ketamine 24 mg/kg (K24) to select an effective dose of ketamine for phase III...
May 5, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28569211/exosomal-amyloid-a-and-lymphatic-vessel-endothelial-hyaluronic-acid-receptor-1-proteins-are-associated-with-disease-activity-in-rheumatoid-arthritis
#10
Jihyung Yoo, Sang Kwang Lee, Mikyung Lim, Donghyuk Sheen, Eun-Hye Choi, Soon Ae Kim
BACKGROUND: Exosomes are thought to play an important role in exchanging information between cells. The proteins and lipids in exosomes play roles in mediating inflammatory and autoimmune diseases. The aim of this study was to identify exosomal candidate proteins that are related to other inflammatory parameters in rheumatoid arthritis (RA). METHODS: The study population consisted of 60 patients with RA: 30 in the clinical remission (CR) group with a Disease Activity Score in 28 joints based on erythrocyte sedimentation rate (DAS28-ESR) ≤2...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28554494/effects-of-a-viscosupplementation-therapy-on-rabbit-menisci-in-an-anterior-cruciate-ligament-transection-model-of-osteoarthritis
#11
A Levillain, H Magoariec, C Boulocher, A Decambron, V Viateau, T Hoc
The aim of this study was to evaluate the morphological, microstructural, and mechanical effects of a viscosupplementation therapy on rabbit menisci at an early stage of osteoarthritis (OA). Anterior cruciate ligament transection (ACLT) was performed in twelve male New-Zealand White rabbits on the right knee joint. Six of these twelve rabbits received a mono intra-articular injection of high molecular weight hyaluronic acid (HA) two weeks after ACLT. Six additional healthy rabbits served as controls. Medial menisci were removed from all right knees (n=18) six weeks after ACLT and were graded macroscopically...
May 17, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28535729/quantitative-genetics-of-circulating-hyaluronic-acid-ha-and-its-correlation-with-hand-osteoarthritis-and-obesity-related-phenotypes-in-a-community-based-sample
#12
Jai Prakash, Gulzhan Gabdulina, Svetlana Trofimov, Gregory Livshits
BACKGROUND: One of the potential molecular biomarkers of osteoarthritis (OA) is hyaluronic acid (HA). HA levels may be related to the severity and progression of OA. However, little is known about the contribution of major risk factors for osteoarthritis, e.g., obesity-related phenotypes and genetics to HA variation. AIM: To clarify the quantitative effect of these factors on HA. METHODS: An ethnically homogeneous sample of 911 apparently healthy European-derived individuals, assessed for radiographic hand osteoarthritis (RHOA), HA, leptin, adiponectin, and several anthropometrical measures of obesity-related phenotypes...
May 24, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28450242/modulating-carbohydrate-based-hydrogels-as-viscoelastic-lubricant-substitute-for-articular-cartilages
#13
Gesmi Milcovich, Filipe E Antunes, Rossella Farra, Gabriele Grassi, Mario Grassi, Fioretta Asaro
Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials...
September 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28420447/ck2-1-a-bone-morphogenetic-protein-receptor-type-ia-mimetic-peptide-repairs-cartilage-in-mice-with-destabilized-medial-meniscus
#14
Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B Kirn Safran, Anja Nohe
BACKGROUND: Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a novel bone morphogenetic protein receptor type I (BMPRI) mimetic peptide, CK2.1, that activates BMPRIa signaling in the absence of bone morphogenetic protein (BMP). Our previous research demonstrated that CK2.1 induced chondrogenesis in vitro and in vivo; however, it is unknown if CK2...
April 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28416171/the-comparison-of-knee-osteoarthritis-treatment-with-single-dose-bone-marrow-derived-mononuclear-cells-vs-hyaluronic-acid-injections
#15
Valdis Goncars, Eriks Jakobsons, Kristaps Blums, Ieva Briede, Liene Patetko, Kristaps Erglis, Martins Erglis, Konstantins Kalnberzs, Indrikis Muiznieks, Andrejs Erglis
OBJECTIVE: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. MATERIALS AND METHODS: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren-Lawrence stage II-III osteoarthritis during the 12-month period were performed...
March 22, 2017: Medicina
https://www.readbyqxmd.com/read/28409101/microdrilling-surgery-augmented-with-intra-articular-bone-marrow-aspirate-concentrate-platelet-rich-plasma-and-hyaluronic-acid-a-technique-for-cartilage-repair-in-the-knee
#16
Joseph E Broyles, M Adaire O'Brien, M Patrick Stagg
The ideal treatment of large full-thickness chondral lesions in the knee, especially "kissing lesions" and osteoarthritis, has not been determined. Microdrilling surgery augmented with injections of peripheral blood stem cells and hyaluronic acid has been used to treat patients with a wide range of articular cartilage disease including patients with bipolar lesions and joint space narrowing. Excellent results in this difficult patient population have been reported, and second-look biopsy has shown repair tissue very similar to native hyaline cartilage...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28397753/hip-arthropathy-in-haemophilia
#17
Christian Carulli, Anna Rosa Rizzo, Massimo Innocenti
Hip arthropathy in haemophilic patients is disabling for hip and other common target joints. Even if bleedings in the hip are not frequent, femoroacetabular alterations may affect the functional ability of patients at a very young age. A haematologic prophylaxis combined with an adequate lifestyle and regular and low-traumatic physical activity are the keys to preventing such arthropathy. In the early stages of arthropathy, anti-inflammatory drugs and physical therapy may be sufficient to limit its progression...
April 8, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28392718/single-arm-open-label-study-of-durolane-nasha-nonanimal-hyaluronic-acid-for-the-treatment-of-osteoarthritis-of-the-thumb
#18
Eloisa Velasco, Mª Victoria Ribera, Joan Pi
INTRODUCTION: Osteoarthritis of the trapeziometacarpal (TMC) joint of the thumb - also known as rhizarthrosis - is painful and has a significant impact on quality of life. Intra-articular injection of hyaluronic acid may potentially meet the need for effective, minimally invasive intervention in patients not responding adequately to initial treatment. We aimed to confirm the safety and effectiveness of viscosupplementation with Durolane (NASHA nonanimal hyaluronic acid) in rhizarthrosis...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28372297/chitosan-a-promising-polymer-for-cartilage-repair-and-viscosupplementation
#19
REVIEW
Fanny Comblain, Guillem Rocasalbas, Sandrine Gauthier, Yves Henrotin
Osteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments are limited to symptoms alleviation. There is a need for a new efficient and safe treatment. Viscosupplementation is a process that aims to restore the normal rheological properties of synovial fluid. For the past years, hyaluronic acid was usually used but this molecule has some limitations including the short residency time in joint cavity...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28359897/chitosan-hyaluronic-acid-hydrogel-for-cartilage-repair
#20
Neethu Mohan, P V Mohanan, A Sabareeswaran, Prabha Nair
The current study investigates the potential of chitosan-hyaluronic acid dialdehyde hydrogels for in vivo cartilage regeneration following two different approaches: Gel alone for cartilage regeneration or combination of chondrocytes and gel for cartilage repair. Critical size osteochondral defects were created in knee joints of Newzealand White rabbits. Allogenic rabbit chondrocytes were encapsulated in hydrogels and gel or gel+cells were implanted in defects aseptically. The regenerated cartilage was analyzed after 12 weeks of implantation...
March 27, 2017: International Journal of Biological Macromolecules
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