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https://www.readbyqxmd.com/read/28725595/a-prospective-evaluation-of-penile-measures-and-glans-penis-sensory-changes-after-penile-prosthetic-surgery
#1
Donghua Xie, Marilin Nicholas, Victor Gheiler, Dylan Perito, Luanda Siano, Igor Kislinger, Guy M Nehrenz, Boris Klopukh, Fernando J Bianco, Paul Perito, Edward Gheiler
BACKGROUND: With better designed devices and lower infection rates, satisfaction with inflatable penile prosthesis (IPP) placement is increasingly high. However, dissatisfaction is still present and there is disagreement regarding length and sensation changes after the IPP placement. The aim of this study was to evaluate changes in penile length, girth and sensitivity after IPP placement. METHODS: From August 2012 to January 2013 all patients undergoing "de novo" IPP surgery were invited to participate in this study...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28698250/clinical-relevance-of-intraperitoneal-pressure-in-peritoneal-dialysis-patients
#2
Loreley A Betancourt
INTRODUCTION: Intraperitoneal pressure (IPP) in peritoneal dialysis (PD) increases in sitting and upright positions and is related to some individual characteristics. Adverse effects can appear with IPP > 20 cm H2O. Few studies about peritoneal transport or abdominal wall problems have directly measured IPP. We measured IPP in our prevalent PD patients to identify the clinical factors related to its variability and its possible association with peritoneal transport and abdominal wall complications...
July 11, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28695490/role-of-cys73-in-the-thermostability-of-farnesyl-diphosphate-synthase-from-geobacillus-stearothermophilus
#3
Petrus Yesaya Samori, Koki Makabe, Norimasa Ohya, Bunpei Hatano, Satoshi Murakami, Tatsuro Kijima
Farnesyl diphosphate synthase (FPPase) is an enzyme that catalyzes the condensation between one molecule of dimethylallyl diphosphate (DMAPP) and two molecules of isopentenyl diphosphate (IPP) to produce farnesyl diphosphate (FPP). FPP is an important precursor in the isoprenoid synthesis pathway. In this study, the crystal structure of FPPase from Geobacillus stearothermophilus (GsFPPase) was determined at 2.31 Å resolution. The structure of GsFPPase shows a three-layered all α-helical fold and conserved functional domains similar to other prenyltransferases...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28686408/mechanism-of-allosteric-inhibition-of-the-enzyme-ispd-by-three-different-classes-of-ligands
#4
Anatol Schwab, Boris Illarionov, Annika Frank, Andrea Kunfermann, Michael Seet, Adelbert Bacher, Matthias C Witschel, Markus Fischer, Michael Groll, François Diederich
Enzymes of the nonmevalonate pathway of isoprenoid biosynthesis are attractive targets for the development of herbicides and drugs against infectious diseases. While this pathway is essential for many pathogens and plants, mammals do not depend on it for the synthesis of isoprenoids. IspD, the third enzyme of the nonmevalonate pathway, is unique in that it has an allosteric regulatory site. We elucidated the binding mode of phenylisoxazoles, a new class of allosteric inhibitors. Allosteric inhibition is effected by large conformational changes of a loop region proximal to the active site...
July 7, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28672185/utilization-of-biodiesel-by-product-as-substrate-for-high-production-of-%C3%AE-farnesene-via-relatively-balanced-mevalonate-pathway-in-escherichia-coli
#5
Shengping You, Qingdian Yin, Jianye Zhang, Chengyu Zhang, Wei Qi, Lan Gao, Zhiping Tao, Rongxin Su, Zhimin He
Farnesene has been identified as suitable jet fuel substitutes and metabolic engineering for microbial production of farnesene is an alternative and attractive route. In this study, due to accumulation of toxic intermediate isopentenyl pyrophosphate (IPP), an engineered Escherichia coli strain harboring heterologous mevalonate pathway produced only 4.11mg/L β-farnesene. Through higher-level expression of isopentenyl diphosphate isomerase and farnesyl diphosphate synthase to minimize the accumulated IPP, another engineered strain with relatively balanced mevalonate pathway was constructed and had the highest production of β-farnesene to date (8...
June 13, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28670326/isolation-and-biochemical-characterization-of-bradykinin-potentiating-peptides-from-bitis-gabonica-rhinoceros
#6
Tamara M Fucase, Juliana M Sciani, Ingrid Cavalcante, Vincent L Viala, Bruno B Chagas, Daniel C Pimenta, Patrick J Spencer
BACKGROUND: Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (BPPs) comprise a class of angiotensin-I converting enzyme (ACE) inhibitors. The BPPs usually consist of oligopeptides with 5 to 13 residues with a high number of proline residues and the tripeptide Ile-Pro-Pro (IPP-tripeptide) in the C-terminus region and have a conserved N-terminal pyroglutamate residue...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28669030/v%C3%AE-9v%C3%AE-2-t-cell-activation-by-strongly-agonistic-nucleotidic-phosphoantigens
#7
Morgane Moulin, Javier Alguacil, Siyi Gu, Asmaa Mehtougui, Erin J Adams, Suzanne Peyrottes, Eric Champagne
Human Vγ9Vδ2 T cells can sense through their TCR tumor cells producing the weak endogenous phosphorylated antigen isopentenyl pyrophosphate (IPP), or bacterially infected cells producing the strong agonist hydroxyl dimethylallyl pyrophosphate (HDMAPP). The recognition of the phosphoantigen is dependent on its binding to the intracellular B30.2 domain of butyrophilin BTN3A1. Most studies have focused on pyrophosphate phosphoantigens. As triphosphate nucleotide derivatives are naturally co-produced with IPP and HDMAPP, we analyzed their specific properties using synthetic nucleotides derived from HDMAPP...
July 1, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28659631/a-retrospective-analysis-of-risk-factors-for-ipp-reservoir-entry-into-the-peritoneum-after-abdominal-wall-placement
#8
M S Gross, D S Stember, B B Garber, P E Perito
Placement of an inflatable penile prosthesis (IPP) is the most effective treatment modality for men with ED refractory to medical management. We have previously demonstrated a protocol for IPP reservoir placement within the abdominal wall musculature, which was shown to be a safer location than traditional placement in the retropubic space of Retzius. The aim of this study was to review our complications with IPP reservoir entry into the peritoneum after abdominal wall placement of the reservoir. We retrospectively reviewed our two patients with peritoneal entry of the reservoir after posterior to transversalis fascia and anterior to transversalis fascia placement during virgin and compromised IPP cases, respectively...
June 29, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28655749/polyprenols-are-synthesized-by-a-plastidial-cis-prenyltransferase-and-influence-photosynthetic-performance
#9
Tariq A Akhtar, Przemysław Surowiecki, Hanna Siekierska, Magdalena Kania, Kristen Van Gelder, Kevin Rea, Lilia Virta, Maritza Vatta, Katarzyna Gawarecka, Jacek Wojcik, Witold Danikiewicz, Daniel Buszewicz, Ewa Swiezewska, Liliana Surmacz
Plants accumulate a family of hydrophobic polymers known as polyprenols, yet how they are synthesized, where they reside in the cell, and what role they serve is largely unknown. Using Arabidopsis thaliana as a model, we present evidence for the involvement of a plastidial cis-prenyltransferase (AtCPT7) in polyprenol synthesis. Gene inactivation and RNAi-mediated knockdown of AtCPT7 eliminated leaf polyprenols while its overexpression increased their content. Complementation tests in the polyprenol-deficient yeast ∆rer2 mutant and enzyme assays with recombinant AtCPT7 confirmed that the enzyme synthesizes polyprenols of approximately 55 carbons in length using geranylgeranyl diphosphate (GGPP) and isopentenyl diphosphate (IPP) as substrates...
June 27, 2017: Plant Cell
https://www.readbyqxmd.com/read/28652878/randomized-controlled-trial-of-laser-vs-bipolar-plasma-vaporization-treatment-of-benign-prostatic-hyperplasia
#10
Thomas A A Skinner, Robert J Leslie, Stephen S Steele, J Curtis Nickel
INTRODUCTION: Prostate vaporization technology is becoming a standard of care for treatment of moderate, symptomatic benign prostatic hyperplasia (BPH). We compared two transurethral prostate vaporization technologies with respect to cost, efficiency, efficacy, safety, and surgical team satisfaction. METHODS: Fifty-five patients meeting standardized symptom criteria for BPH were randomized to either Olympus Plasma Button(TM) or Biolitec EVOLVE(®) diode laser vaporization...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28631916/-intravesical-prostatic-protrusion-in-diagnosing-infravesical-obstruction-in-men-with-benign-prostatic-hyperplasia
#11
G G Krivoborodov, N S Efremov, A D Bolotov
Infravesical obstruction (IVO) is an important characteristic of the functional state of male lower urinary tract. It is believed that IVO confirmed by pressure-flow study findings warrants switching from a medical to surgical management of lower urinary tract symptoms (LUTS). Intravesical prostatic protrusion (IPP) is a new indicator for detecting IVO secondary to benign prostatic hyperplasia (BPH). This indicator has several advantages over other non-invasive methods for evaluating IVO. The initial findings on the relationship between IPP and IVO suggest the feasibility of its clinical use as a screening tool in men with obstructive voiding symptoms...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28612663/development-of-multiple-unit-pellet-system-tablets-by-employing-the-sedem-expert-diagram-system-i-pellets-with-different-sizes
#12
Hannlie Hamman, Josias Hamman, Anita Wessels, Jacques Scholtz, Jan Steenekamp
Multiple-unit pellet systems (MUPS) provide several pharmacokinetic and pharmacodynamic advantages over single-unit dosage forms, however, compression of pellets into MUPS tablets present certain challenges. Although the SeDeM Expert Diagram System (SeDeM EDS) was originally developed to provide information about the most appropriate excipient and the minimum amount thereof that is required for producing direct compressible tablets, this study investigated the possibility to apply the SeDeM EDS in the production of MUPS tablets...
June 14, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28612271/overexpression-of-dnaj-like-chaperone-enhances-carotenoid-synthesis-in-chlamydomonas-reinhardtii
#13
Tateki Morikawa, Yusuke Uraguchi, Shohei Sanda, Satoshi Nakagawa, Shigeki Sawayama
Production of functional carotenoids using microalgae may facilitate the commercialization of anti-aging nutritional supplements. The green alga Chlamydomonas reinhardtii uses a non-mevalonate (MEP) pathway for isopentenyl diphosphate (IPP) synthesis. Two enzymes thought to play important roles in this MEP pathway to IPP synthesis are 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and reductase (DXR). DnaJ-like chaperone (Orange protein) is thought to support phytoene synthase, a key enzyme in plant carotenoid synthesis...
June 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28606775/oxidized-regenerated-cellulose-fibrillar%C3%A2-reduces-risk-of-postoperative-corporal-bleeding-following-inflatable-penile-prosthesis-surgery
#14
Alexander T Rozanski, Boyd R Viers, Alexander G Liu, Nabeel A Shakir, Travis J Pagliara, Jeremy M Scott, Mary L West, Allen F Morey
OBJECTIVES: To report our initial experience with oxidized regenerated cellulose (ORC; Surgicel Fibrillar™) as a hemostatic adjunct during inflatable penile prosthesis (IPP) surgery. MATERIALS AND METHODS: Beginning in April 2016, ORC pledgets were placed within the corporotomy closures of all men undergoing IPP insertion. Perioperative characteristics and outcomes including cumulative postoperative drain output were evaluated among consecutive cases with (April 2016 to October 2016) and without ORC (December 2015 to March 2016) using an identical surgical technique by a single surgeon...
June 9, 2017: Urology
https://www.readbyqxmd.com/read/28595821/modified-inflatable-penile-prosthesis-reservoir-placement-into-space-of-retzius-comparing-outcomes-in-men-with-or-without-prior-pelvic-surgery
#15
Edward M Capoccia, Jessica N Phelps, Laurence A Levine
BACKGROUND: Traditional inflatable penile prosthesis (IPP) reservoir placement has rare but potentially serious complications including damage to local structures, and Levine and Hoeh (J Sex Med 2012;9:2759-2769) described a modified technique designed to avoid these complications. AIM: To determine whether the modified Jorgenson scissors technique is safe and effective in patients who have had prior pelvic surgery. METHODS: A retrospective chart review was performed on all patients who had a three-piece IPP placed by a single urologist from 2011 to 2015...
June 5, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28580927/the-atp-binding-cassette-transporter-a1-regulates-phosphoantigen-release-and-v%C3%AE-9v%C3%AE-2-t-cell-activation-by-dendritic-cells
#16
Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti, Massimo Massaia
Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms. Here we show that the ATP-binding cassette transporter A1 (ABCA1) mediates extracellular IPP release from dendritic cells (DC) in cooperation with apolipoprotein A-I (apoA-I) and butyrophilin-3A1. IPP concentrations in the supernatants are sufficient to induce Vγ9Vδ2 T cell proliferation after DC mevalonate pathway inhibition with zoledronic acid (ZA)...
June 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28553002/full-characterization-of-multiphase-multimorphological-kinetics-in-flow-induced-crystallization-of-ipp-at-elevated-pressure
#17
E M Troisi, H J M Caelers, G W M Peters
Understanding the complex crystallization behavior of isotactic polypropylene (iPP) in conditions comparable to those found in polymer processing, where the polymer melt experiences a combination of high shear rates and elevated pressures, is key for modeling and therefore predicting the final structure and properties of iPP products. Coupling a unique experimental setup, capable to apply wall shear rates similar to those experienced during processing and carefully control the pressure before and after flow is imposed, with in situ X-ray scattering and diffraction techniques (SAXS and WAXD) at fast acquisition rates (up to 30 Hz), a well-defined series of short-term flow experiments are carried out using 16 different combinations of wall shear rates (ranging from 110 to 440 s(-1)) and pressures (100-400 bar)...
May 23, 2017: Macromolecules
https://www.readbyqxmd.com/read/28549159/a-non-photosynthetic-diatom-reveals-early-steps-of-reductive-evolution-in-plastids
#18
Ryoma Kamikawa, Daniel Moog, Stefan Zauner, Goro Tanifuji, Ken-Ichiro Ishida, Hideaki Miyashita, Shigeki Mayama, Tetsuo Hashimoto, Uwe-G Maier, John M Archibald, Yuji Inagaki
Non-photosynthetic plastids retain important biological functions and are indispensable for cell viability. However, the detailed processes underlying the loss of plastidal functions other than photosynthesis remain to be fully understood. In this study, we used transcriptomics, subcellular localization, and phylogenetic analyses to characterize the biochemical complexity of the non-photosynthetic plastids of the apochlorotic diatom Nitzschia sp. NIES-3581. We found that these plastids have lost isopentenyl pyrophosphate (IPP) biosynthesis and ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO)-based carbon fixation but have retained various proteins for other metabolic pathways, including amino acid biosynthesis, and a portion of the Calvin-Benson cycle comprised only of glycolysis/gluconeogenesis, and the reductive pentose phosphate pathway (rPPP)...
May 26, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28546878/effects-of-medicare-coverage-of-a-welcome-to-medicare-visit-on-use-of-preventive-services-among-new-medicare-enrollees
#19
Boon Peng Ng, Gail A Jensen, Heather Fritz
In January 2005, Medicare began covering a one-time initial preventive physical examination (IPPE), also called a "Welcome-to-Medicare" visit, during a beneficiary's first 6 months under Part B. This paper examines the effects of offering Medicare IPPE coverage on the use of mammograms, breast self-exams, Pap smears, prostate cancer screenings, cholesterol screenings, and flu vaccines among beneficiaries new to Part B. We adopt a difference-in-difference estimator and estimate a set of multivariate logit models to quantify the effects of introducing Medicare IPPE coverage on the use of preventive services...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28546066/v-neck-technique-a-novel-improvement-to-the-infra-pubic-placement-of-an-inflatable-penile-implant
#20
Bhavik B Shah, Adam S Baumgarten, Kevin Morgan, Jonathan A Beilan, Michael Bickell, Ricardo Munarriz, Justin Parker, Rafael Carrion
BACKGROUND: Infra-pubic placement of an inflatable penile prosthesis (IPP) has a well-known configuration deformity from contralateral tubing that crosses the corporal bodies, resulting in tubing visibility and irritation under the penile skin. AIM: To present a novel step to eliminate this tubing crossover deformity. METHODS: The V-neck technique was applied to five patients, two of whom underwent suprapubic fat pad excision with simultaneous infra-pubic IPP placement and three patients who underwent only infra-pubic IPP placement...
May 22, 2017: Journal of Sexual Medicine
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