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https://www.readbyqxmd.com/read/27910026/recurrent-cytogenetic-abnormalities-in-myelodysplastic-syndromes
#1
Meaghan Wall
Cytogenetic analysis has an essential role in diagnosis, classification, and prognosis of myelodysplastic syndromes (MDS). Some cytogenetic abnormalities are sufficiently characteristic of MDS to be considered MDS defining in the appropriate clinical context. MDS with isolated del(5q) is the only molecularly defined MDS subtype. The genes responsible for many aspects of 5q- syndrome, the distinct clinical phenotype associated with this condition, have now been identified. Cytogenetics forms the cornerstone of the most widely adopted prognostic scoring systems in MDS, the international prognostic scoring system (IPSS) and the revised international prognostic scoring system (IPPS-R)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27872031/penile-prosthesis-infections-a-review-of-risk-factors-prevention-and%C3%A2-treatment
#2
REVIEW
Miguel Pineda, Arthur L Burnett
INTRODUCTION: Inflatable penile prosthesis (IPP) surgery has been performed for more than 40 years. IPP infection rates have decreased owing to advances in manufacturing and surgical technique but have remained a devastating complication. AIMS: To describe the pathophysiology of infections, examine evidence associating clinical risk factors with IPP infection, assess the benefit of techniques aimed at preventing and managing infection, and discuss future directions...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27851826/transcriptional-responses-and-gentiopicroside-biosynthesis-in-methyl-jasmonate-treated-gentiana-macrophylla-seedlings
#3
Xiaoyan Cao, Xiaorong Guo, Xinbing Yang, Huaiqin Wang, Wenping Hua, Yihan He, Jiefang Kang, Zhezhi Wang
Gentiana macrophylla, a medicinal plant with significant pharmacological properties, contains the bioactive compound gentiopicroside. Methyl jasmonate (MeJA) is an effective elicitor for enhancing the production of such compounds. However, little is known about MeJA-mediated biosynthesis of gentiopicroside. We investigated this phenomenon as well as gene expression profiles to determine the molecular mechanisms for MeJA-mediated gentiopicroside biosynthesis and regulation in G. macrophylla. Our HPLC results showed that Gentiana macrophylla seedlings exposed to MeJA had significantly higher concentrations of gentiopicroside when compared with control plants...
2016: PloS One
https://www.readbyqxmd.com/read/27814796/access-to-opportunities-for-bilingualism-for-individuals-with-developmental-disabilities-key-informant-interviews
#4
Julia Scherba de Valenzuela, Elizabeth Kay-Raining Bird, Karisa Parkington, Pat Mirenda, Kate Cain, Andrea A N MacLeod, Eliane Segers
The purpose of this article is to describe the results of a thematic analysis of 79 semi-structured interviews collected at six research sites in four countries in relation to the inclusion and exclusion of students with developmental disabilities (DD) in and from special education and bilingual opportunities. The participants were individuals with expertise either in special needs and/or language education to support bilingualism (e.g., second language (L2) instruction), who served as key informants about service delivery and/or policy in these areas...
September 2016: Journal of Communication Disorders
https://www.readbyqxmd.com/read/27790911/release-of-the-anti-hypertensive-tripeptides-valine-proline-proline-and-isoleucine-proline-proline-from-bovine-milk-caseins-during-in-vitro-gastro-intestinal-digestion
#5
Giuseppina Sefora Rutella, Lisa Solieri, Serena Martini, Davide Tagliazucchi
The aim of this study was to identify and quantify the release of antihypertensive tripeptides valine-proline-proline (VPP) and isoleucine-proline-proline (IPP) during in vitro oro-gastro-intestinal (OGI) digestion of bovine skimmed milk. The experimental approach combined the recently developed harmonized static in vitro digestion (IVD) model and targeted mass spectrometry in order to monitor peptide generation. We firstly demonstrated that VPP and IPP are released from bovine milk proteins during in vitro OGI digestion at final concentrations of 354...
October 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27782611/image-quality-method-as-a-possible-way-of-in-situ-monitoring-of-in-vessel-mirrors-in-a-fusion-reactor
#6
V G Konovalov, V S Voitsenya, M N Makhov, I V Ryzhkov, A N Shapoval, S I Solodovchenko, A F Stan, V N Bondarenko, A J H Donné, A Litnovsky
The plasma-facing (first) mirrors in ITER will be subject to sputtering and/or contamination with rates that will depend on the precise mirror locations. The resulting influence of both these factors can reduce the mirror reflectance (R) and worsen the transmitted image quality (IQ). This implies that monitoring the mirror quality in situ is an actual desire, and the present work is an attempt towards a solution. The method we propose is able to elucidate the reason for degradation of the mirror reflectance: sputtering by charge exchange atoms or deposition of contaminated layers...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27774312/repeatability-and-reproducibility-of-quantitative-corneal-shape-analysis-after-orthokeratology-treatment-using-image-pro-plus-software
#7
Ying Mei, Zhiping Tang, Zhouyue Li, Xiao Yang
Purpose. To evaluate the repeatability and reproducibility of quantitative analysis of the morphological corneal changes after orthokeratology treatment using "Image-Pro Plus 6.0" software (IPP). Methods. Three sets of measurements were obtained: two sets by examiner 1 with 5 days apart and one set by examiner 2 on the same day. Parameters of the eccentric distance, eccentric angle, area, and roundness of the corneal treatment zone were measured using IPP. The intraclass correlation coefficient (ICC) and repetitive coefficient (COR) were used to calculate the repeatability and reproducibility of these three sets of measurements...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27754129/os-25-04-the-changes-of-arterial-stiffness-monitored-with-cardio-ankle-vascular-index-cavi-during-raised-intracranial-pressure-in-the-rabbit
#8
Chikao Miyazaki, Mao Takahashi, Kazuhiro Shimizu, Tatsuo Chiba, Takenori Morisita, Tomoyuki Yamamoto, Nobuo Sugo, Akira Takahara, Kohji Shirai
OBJECTIVE: Cardio ankle vascular index (CAVI) is reflecting stiffness of the arterial tree from the origin of aorta to the ankles. We observed elevated CAVI in patients who suffered from apoplexy attack. To clarify the role and the mechanism by which arterial stiffness elevated just after apoplexy attack, the effect of enhanced intracranial pressure (ICP) by injecting saline into the cisterna magna of the rabbit on blood pressure, CAVI and cervical blood flow, were studied. Furthermore the role of sympathetic nerve was studied...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754016/br-04-2-concentration-response-modeling-of-antihypertensive-drugs-implication-in-clinical-development
#9
Dong-Seok Yim
In the early phase of clinical development of antihypertensive drugs, quantitative modeling to predict their dose-concentration-response relationship is important to plan future clinical development and finding optimal dosage regimen at marketing approval. Two cases of concentration-response models of antihypertensive are presented here.Case 1: Carvedilol is a α1- and nonselective β- adrenergic receptor antagonist currently used for the management of mild-to-moderate essential hypertension and congestive heart failure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27710765/divergent-perceptions-of-barriers-to-diabetic-retinopathy-screening-among-patients-and-care-providers-los-angeles-california-2014-2015
#10
Yang Lu, Lilian Serpas, Pauline Genter, Betty Anderson, David Campa, Eli Ipp
INTRODUCTION: Despite availability of screening for diabetic retinopathy, testing is underused by many low-income and racial/ethnic minority patients with diabetes. We examined perceived barriers to diabetic retinopathy screening among low-income patients and their health care providers and provider staffers. METHODS: We collected survey data from 101 patients with diabetes and 44 providers and staffers at a safety-net clinic where annual diabetic retinopathy screening rates were low...
October 6, 2016: Preventing Chronic Disease
https://www.readbyqxmd.com/read/27697865/the-inositol-pyrophosphate-kinase-asp1-modulates-chromosome-segregation-fidelity-and-spindle-function-in-s-pombe
#11
Boris Topolski, Visnja Jakopec, Natascha A Künzel, Ursula Fleig
Chromosome transmission fidelity during mitosis is of critical importance for the fitness of an organism as mistakes will lead to aneuploidy, which has a causative role in numerous severe diseases. Proper segregation of chromosomes depends on interdependent processes at the microtubule-kinetochore interface and the spindle assembly checkpoint. Here we report the discovery of a new element essential for chromosome transmission fidelity that implicates inositol pyrophosphates (IPPs) as playing a key role in this process...
October 3, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27685796/insights-into-the-utility-of-the-focal-adhesion-scaffolding-proteins-in-the-anaerobic-fungus-orpinomyces-sp-c1a
#12
Shelby Calkins, Noha H Youssef
Focal adhesions (FAs) are large eukaryotic multiprotein complexes that are present in all metazoan cells and function as stable sites of tight adhesion between the extracellular matrix (ECM) and the cell's cytoskeleton. FAs consist of anchor membrane protein (integrins), scaffolding proteins (e.g. α-actinin, talin, paxillin, and vinculin), signaling proteins of the IPP complex (e.g. integrin-linked kinase, α-parvin, and PINCH), and signaling kinases (e.g. focal adhesion kinase (FAK) and Src kinase). While genes encoding complete focal adhesion machineries are present in genomes of all multicellular Metazoa; incomplete machineries were identified in the genomes of multiple non-metazoan unicellular Holozoa, basal fungal lineages, and amoebozoan representatives...
2016: PloS One
https://www.readbyqxmd.com/read/27683231/nano-bio-engineered-carbon-dot-peptide-functionalized-water-dispersible-hyperbranched-polyurethane-for-bone-tissue-regeneration
#13
Satyabrat Gogoi, Somnath Maji, Debasish Mishra, K Sanjana P Devi, Tapas Kumar Maiti, Niranjan Karak
The present study delves into a combined bio-nano-macromolecular approach for bone tissue engineering. This approach relies on the properties of an ideal scaffold material imbued with all the chemical premises required for fostering cellular growth and differentiation. A tannic acid based water dispersible hyperbranched polyurethane is fabricated with bio-nanohybrids of carbon dot and four different peptides (viz. SVVYGLR, PRGDSGYRGDS, IPP, and CGGKVGKACCVPTKLSPISVLYK) to impart target specific in vivo bone healing ability...
September 29, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27676856/an-injury-prevention-program-is-able-to-reduce-the-number-of-injury-complaints-at-medium-term-in-athletics
#14
Pascal Edouard, Emmanuelle Cugy, Romain Dolin, Nicolas Morel, Kathrin Steffen
OBJECTIVE: The incidence of injuries in athletics is important, with consequences at short and long terms in sport, health, social and professional levels. It is therefore important to define strategies to reduce the incidence and severity of injuries in athletics. The objective of this study was to determine whether an injury prevention program (IPP) can reduce the occurrence and/or severity of injuries related to the practice of athletics. MATERIAL AND METHODS: The IPP has been developed, based on current scientific knowledge, targeting exercises on the most common injuries in athletics (hamstring muscle injury, Achilles and patellar tendinopathy, low back pain, ankle sprain) and selecting exercises known to treat and/or prevent these injuries (care stability, hamstrings and leg eccentric muscle strengthening, pelvis balance and stabilizing work)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27661293/examining-the-construct-validity-of-the-mmpi-2-rf-interpersonal-functioning-scales-using-the-computerized-adaptive-test-of-personality-disorder-as-a-comparative-framework
#15
Annabel O Franz, Tiffany M Harrop, David M McCord
This study aimed to examine the construct validity of the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) interpersonal functioning scales (Ben-Porath & Tellegen, 2008/2011 ) using as a criterion measure the Computerized Adaptive Test of Personality Disorder-Static Form (CAT-PD-SF; Simms et al., 2011 ). Participants were college students (n = 98) recruited through the university subject pool. A series of a priori hypotheses were developed for each of the 6 interpersonal functioning scales of the MMPI-2-RF, expressed as predicted correlations with construct-relevant CAT-PD-SF scales...
September 23, 2016: Journal of Personality Assessment
https://www.readbyqxmd.com/read/27643056/os-25-04-the-changes-of-arterial-stiffness-monitored-with-cardio-ankle-vascular-index-cavi-during-raised-intracranial-pressure-in-the-rabbit
#16
Chikao Miyazaki, Mao Takahashi, Kazuhiro Shimizu, Tatsuo Chiba, Takenori Morisita, Tomoyuki Yamamoto, Nobuo Sugo, Akira Takahara, Kohji Shirai
OBJECTIVE: Cardio ankle vascular index (CAVI) is reflecting stiffness of the arterial tree from the origin of aorta to the ankles. We observed elevated CAVI in patients who suffered from apoplexy attack. To clarify the role and the mechanism by which arterial stiffness elevated just after apoplexy attack, the effect of enhanced intracranial pressure (ICP) by injecting saline into the cisterna magna of the rabbit on blood pressure, CAVI and cervical blood flow, were studied. Furthermore the role of sympathetic nerve was studied...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642927/br-04-2-concentration-response-modeling-of-antihypertensive-drugs-implication-in-clinical-development
#17
Dong-Seok Yim
In the early phase of clinical development of antihypertensive drugs, quantitative modeling to predict their dose-concentration-response relationship is important to plan future clinical development and finding optimal dosage regimen at marketing approval. Two cases of concentration-response models of antihypertensive are presented here.Case 1: Carvedilol is a α1- and nonselective β- adrenergic receptor antagonist currently used for the management of mild-to-moderate essential hypertension and congestive heart failure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27641925/submuscular-abdominal-wall-placement-of-ipp-reservoir
#18
Tariq S Hakky, Taylor P Kohn, Ranjith Ramasamy
The Surgical Techniques Section is sponsored in part by Coloplast.
October 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27639798/a-novel-thermal-activated-shape-memory-penile-prosthesis-comparative-mechanical-testing
#19
Brian Le, Kevin McVary, Kevin McKenna, Alberto Colombo
OBJECTIVE: To compare a novel nickel-titanium (Ni-Ti) shape memory alloy (SMA) penile prosthesis of our own design with commercially available prostheses using a format similar to mechanical testing done at major penile prosthesis manufacturers. We evaluated the mechanical parameters of commercially available penile prostheses and used this information to guide the development of the Ni-Ti-based physiological penile prosthesis that expands and becomes erect with a small amount of heat applied...
September 14, 2016: Urology
https://www.readbyqxmd.com/read/27629988/global-ionospheric-modelling-using-multi-gnss-beidou-galileo-glonass-and-gps
#20
Xiaodong Ren, Xiaohong Zhang, Weiliang Xie, Keke Zhang, Yongqiang Yuan, Xingxing Li
The emergence of China's Beidou, Europe's Galileo and Russia's GLONASS satellites has multiplied the number of ionospheric piercing points (IPP) offered by GPS alone. This provides great opportunities for deriving precise global ionospheric maps (GIMs) with high resolution to improve positioning accuracy and ionospheric monitoring capabilities. In this paper, the GIM is developed based on multi-GNSS (GPS, GLONASS, BeiDou and Galileo) observations in the current multi-constellation condition. The performance and contribution of multi-GNSS for ionospheric modelling are carefully analysed and evaluated...
2016: Scientific Reports
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