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Platelet rich plasma injection

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https://www.readbyqxmd.com/read/28105983/effect-of-bone-marrow-aspirate-concentrate-platelet-rich-plasma-on-tendon-derived-stem-cells-and-rotator-cuff-tendon-tear
#1
Sun Jeong, Da Hyun, Jong Wook, Silvia Park, Sang Jun
Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon derived stem cells (TDSCs) but there has been no study about the effect of BMAC-PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC-PRP on the TDSCs and to find the therapeutic effect of BMAC-PRP on the rotator cuff tendon tear. Chondrogenic and osteogenic potential of TDSCs decreased, but adipogenic potential of TDSCs revealed no significant difference when they were co-cultured with BMAC-PRP...
January 20, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28093371/sonographically-guided-knee-meniscus-injections-feasibility-techniques-and-validation
#2
Michael R Baria, Jacob L Sellon, Dan Lueders, Jay Smith
BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although prior research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described. OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28066748/the-use-of-platelet-rich-plasma-to-augment-conservative-and-surgical-treatment-of-hip-and-pelvic-disorders
#3
REVIEW
Matthew J Kraeutler, Tigran Garabekyan, Omer Mei-Dan
BACKGROUND: In recent years, platelet-rich plasma (PRP) has gained popularity within the orthopaedic community as a treatment modality to enhance tissue healing. PURPOSE: This review aims to concisely present the current indications for PRP injections in the treatment of hip and pelvic pathologies and to describe some novel applications for PRP which have not yet been reported in the literature. METHODS: We reviewed the literature on the non-operative and operative indications for PRP in the treatment of hip and pelvic pathologies...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28061032/effects-of-platelet-rich-plasma-with-concomitant-use-of-a-corticosteroid-on-tenocytes-from-degenerative-rotator-cuff-tears-in-interleukin-1%C3%AE-induced-tendinopathic-conditions
#4
Chris Hyunchul Jo, Seung Yeon Lee, Kang Sup Yoon, Sue Shin
BACKGROUND: A corticosteroid injection is commonly used to treat tendinopathy, but it has been associated with negative effects on tendon homeostasis. Platelet-rich plasma (PRP) is known to have proliferative and anabolic effects as well as cytoprotective effects against corticosteroids on tenocytes. However, the combined effects of a corticosteroid and PRP on the anti-inflammatory, matrix synthesis, and cytoprotective potential of tenocytes in conditions simulating tendinopathy have not been investigated...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28028519/beneficial-effects-of-platelet-rich-plasma-on-improvement-of-pain-severity-and-physical-disability-in-patients-with-plantar-fasciitis-a-randomized-trial
#5
Babak Vahdatpour, Lida Kianimehr, Ahmad Moradi, Shila Haghighat
BACKGROUND: The present study aimed to clinically examine the effects of platelet-rich plasma (PRP) on improvement of plantar fasciitis and its related manifestations. PATIENTS AND METHODS: This single-blind randomized controlled trial was performed on 32 consecutive patients with the final diagnosis of plantar fasciitis that were randomly assigned to the case group (that received PRP, n = 16) and the control group (that received corticosteroid as methylprednisolone 1 ml plus lidocaine 1 ml, n = 16)...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28024792/effects-of-local-platelet-rich-plasma-injection-on-the-rate-of-orthodontic-tooth-movement-in-a-rat-model-a-histomorphometric-study
#6
Ayşegül Güleç, Banu Çakırer Bakkalbaşı, Alev Cumbul, Ünal Uslu, Burçin Alev, Ayşen Yarat
INTRODUCTION: The aims of this study were to determine the effects of different concentrations of platelet-rich plasma (PRP) on alveolar bone density and orthodontic tooth movement. METHODS: Seventy-six rats were divided into 2 groups: a moderate concentration PRP injection group (n = 38) and a high concentration PRP injection group (n = 38). In each group, 5 time points were studied: 3, 7, 14, 21, and 60 days. Before orthodontic mesialization of the maxillary first molars, moderate and high concentrations of PRP were injected on the right sides of the molar buccal sulcus, and the left sides served as the controls...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28019703/a-clinically-relevant-hydrogel-based-on-hyaluronic-acid-and-platelet-rich-plasma-as-a-carrier-for-mesenchymal-stem-cells-rheological-and-biological-characterization
#7
Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Matteo D'Este, Caterina Cattani, Giuseppina Catanzaro, Maria Cristina Tirindelli, Lorenza Lazzari, Mauro Alini, Rosaria Giordano, Vincenzo Denaro
Intervertebral disc regeneration is quickly moving towards clinical applications. However, it is still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new injectable hydrogel composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed to generate a clinically relevant cell carrier for disc regeneration. PRP/HA/BTX blend was tested for rheological properties. Amplitude sweep, frequency sweep and rotational measurements were performed and viscoelastic properties were evaluated...
December 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28018908/partial-cranial-cruciate-ligament-tears-treated-with-stem-cell-and-platelet-rich-plasma-combination-therapy-in-36-dogs-a-retrospective-study
#8
Sherman O Canapp, Christopher S Leasure, Catherine Cox, Victor Ibrahim, Brittany J Carr
OBJECTIVE: To evaluate outcomes in 36 dogs with a partial cranial cruciate ligament (CCL) tear treated with autologous bone marrow aspirate concentrate (BMAC) or adipose-derived progenitor cells (ADPC) with platelet-rich plasma (PRP) combination. MATERIALS AND METHODS: Medical records of client-owned dogs diagnosed with an early partial (≤50%) tear of the craniomedial band of the CCL that was treated with BMAC-PRP or ADPC-PRP were reviewed from 2010 to 2015. Signalment, medical history, physical and orthopedic examination, objective temporospatial gait analyses, radiographs, day 0 and day 90 diagnostic arthroscopy findings, treatment, and outcome were among the data collected...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28018086/leukocyte-poor-platelet-rich-plasma-to-treat-degenerative-meniscal-tear-a-case-report
#9
J P Betancourt, W D Murrell
A traumatic and/or degenerative meniscus lesion is thought to be a clinical manifestation of early-onset osteoarthritis (OA), which is a chronic progressive condition that can cause substantial pain and disability. Platelet-rich plasma (PRP) is an emerging treatment option that has been reported to improve healing. Here, we present a case of a 29-year-old woman, with left anterior and medial knee pain, without history of trauma or injury. The patient was managed with leukocyte-poor PRP injections derived from her peripheral blood with high concentrations of platelets, platelet-derived growth factors, and bioactive proteins, with a total follow-up of 30 months...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28012636/efficacy-of-platelet-rich-plasma-in-the-treatment-of-knee-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#10
Wen-Li Dai, Ai-Guo Zhou, Hua Zhang, Jian Zhang
PURPOSE: To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections for the treatment knee of osteoarthritis (OA). METHODS: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane database through April 2016 to identify Level I randomized controlled trials that evaluated the clinical efficacy of PRP versus control treatments for knee OA. The primary outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores...
December 22, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28002901/homologous-platelet-rich-plasma-for-the-treatment-of-knee-involvement-in-primary-sj%C3%A3-gren%C3%A2-s-syndrome
#11
C Bottegoni, L Farinelli, A Aquili, E Chiurazzi, A Gigante
Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by dry eyes, dry mouth, and other clinical manifestations. The most common extraglandular manifestation of pSS is articular involvement and to date their management is unclear. The aims of the current pilot study were to assess the safety and the outcomes of homologous platelet-rich plasma (HPRP) injections in pSS cohort affected by knee arthralgia/arthritis at short-term follow up. This pilot study provides the first evidence that HPRP injections are a safe treatment and induce a short-term clinical improvement...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28002896/comparing-hybrid-hyaluronic-acid-with-prp-in-end-career-athletes-with-degenerative-cartilage-lesions-of-the-knee
#12
R Papalia, B Zampogna, F Russo, S Vasta, M C Tirindelli, C Nobile, A C Di Martino, G Vadalà, V Denaro
Cartilage lesions are very common causes of chronic knee pain in athletes. Current treatment options consist in conservative strategies, such as viscosupplementation and platelet-rich plasma injections. This randomized controlled trial aims to investigate the effect of intra-articular Hybrid Hyaluronic Acid injections compared to PRP for the treatment of cartilage lesions among athletes at the end of their career. Since March 2015, 48 professional soccer players were randomized into two groups: 24 patients received 3 injections of HHA and 23 patients received 3 intra-articular injections of PRP...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28002864/ultrasound-guided-platelet-rich-plasma-treatment-application-and-technique
#13
Kenneth S Lee
Platelet-rich plasma injection is a minimally invasive treatment method for common overuse tendon injuries. This article discusses the biology of platelet-rich plasma (PRP), the healing cascade that PRP promotes, and how PRP composition may differ depending on centrifuge method. It also highlights the common uses of PRP tendon injection and offers an update on the most current clinical evidence-based literature.
November 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/27999456/investigating-the-effect-of-intra-articular-platelet-rich-plasma-injection-on-union-pain-and-function-improvement-in-patients-with-scaphoid-fracture
#14
Hamid Namazi, Toomaj Kayedi
Introduction Fracture of the scaphoid bone is the most common fracture of the carpus. However, the fracture union occurs late or may not heal. Sometimes, fracture healing requires prolong immobilization. Because of potential for joint stiffness, muscle atrophy, or the inability to use the hand during and after prolonged immobilization, there is great incentive to develop therapies that will accelerate bone healing and allow a quick return to work. To date, the effect of platelet-rich plasma (PRP) on scaphoid fracture has not been studied...
December 2016: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/27998240/superparamagnetic-iron-oxide-nanoparticles-in-musculoskeletal-biology
#15
Shama R Iyer, Su Xu, Joseph P Stains, Craig H Bennett, Richard M Lovering
The use of platelet-rich plasma and mesenchymal stem cells has garnered much attention in orthopedic medicine, focusing on the biological aspects of cell function. However, shortly after systemic delivery, or even a local injection, few of the transplanted stem cells or platelets remain at the target site. Improvement in delivery, and the ability to track and monitor injected cells, would greatly improve clinical translation. Nanoparticles can effectively and quickly label most cells in vitro, and evidence to date suggests such labeling does not compromise the proliferation or differentiation of cells...
January 11, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27992290/patient-reported-outcomes-following-platelet-rich-plasma-injections-in-treating-osteochondral-lesions-of-the-talus-a-critically-appraised-topic
#16
Samuel F Jazzo, Daniel Scribner, Stephanie Shay, Kyung-Min Kim
: Clinical Scenario: Osteochondral lesions (OCLs) of the talus can result from ankle sprains which are the most common injury in the physically active. Recently, Platelet-rich Plasma (PRP) has been used to develop an innovate treatment for OCLs of the Talus. CLINICAL QUESTION: Do PRP injections improve self-reported pain and ankle function in patients with OCL of the talus? Summary of Key Findings: Three randomized-controlled trials were included. One of the studies compared a single dose of PRP to a single dose of hyaluronic acid (HA) or saline when added as an adjunct to microfracture surgery...
December 19, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27989008/a-prospective-study-comparing-platelet-rich-plasma-and-la-corticosteroid-in-intra-articular-injection-for-the-treatment-of-lumbar-facet-joint-syndrome
#17
Jiuping Wu, Jingjing Zhou, Chibing Liu, Jun Zhang, Wei Xiong, Yang Lv, Rui Liu, Ruiqiang Wang, Zhenwu Du, Zhang Guizhen, Qinyi Liu
OBJECTIVES: To compare the effectiveness and safety between autologous platelet-rich plasma (PRP) and LA/corticosteroid in intra-articular injection for the treatment of lumbar facet joint syndrome. METHODS: Forty-six eligible patients with lumbar facet joint syndrome were randomized into group A (intra-articular injection with PRP) and group B (intra-articular injection with LA/corticosteroid). The following contents were evaluated: pain visual analog scale (VAS) at rest and during flexion, and the Roland-Morris Disability Questionnaire (RMQ), Oswestry Disability Index (ODI), and modified MacNab criteria for pain relief and applications of post-treatment drugs...
December 18, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27986140/intradermal-injection-of-autologous-platelet-rich-plasma-for-the-treatment-of-vulvar-lichen-sclerosus
#18
Andrew T Goldstein, Michelle King, Charles Runels, Meghan Gloth, Richard Pfau
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27975027/use-of-platelet-rich-plasma-for-vulvovaginal-autoimmune-conditions-like-lichen-sclerosus
#19
Fariba Behnia-Willison, Nina Reza Pour, Behrang Mohamadi, Nadia Willison, Madeleine Rock, Ian W Holten, Robert O'Shea, Joseph Miller
BACKGROUND: Lichen sclerosus (LS) is an inflammatory dermatosis with autoimmune pathogenesis. Although relatively common, its true incidence is unknown and likely underestimated. LS is usually anogenital, but in around 10% of patients, it can present as extragenital lesions. Continuous administration of topical corticosteroids is the mainstay of medical treatment. Other treatments are available but are only occasionally prescribed along with or instead of topical steroids. Injection of platelet-rich plasma (PRP) into affected areas has been reported to result in the regeneration of normal skin...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27921443/platelet-rich-plasma-versus-corticosteroid-injections-for-carpal-tunnel-syndrome
#20
Hakan Uzun, Ozan Bitik, Öznur Uzun, Umut Sinan Ersoy, Erdem Aktaş
BACKGROUND: Platelet-rich plasma therapy has the potential to promote peripheral nerve regeneration through the autologous supply of growth factors. Therefore, this study aimed to compare the effects of platelet-rich plasma injections with the effects of corticosteroid injections in the treatment of carpal tunnel syndrome. METHODS: In total, 40 patients with mild carpal tunnel syndrome were equally divided into two groups. Nerve conduction studies were carried out, and the Boston Carpal Tunnel Questionnaire was administered to both groups before treatment...
December 6, 2016: Journal of Plastic Surgery and Hand Surgery
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