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Platelet rich plasma injection

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https://www.readbyqxmd.com/read/28629466/intra-articular-injection-in-the-knee-of-adipose-derived-stromal-cells-stromal-vascular-fraction-and-platelet-rich-plasma-for-osteoarthritis
#1
Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim
BACKGROUND: Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. We evaluated the safety and preliminary efficacy of administering SVF and PRP intra-articularly into patients with osteoarthritis grade 1 and 2. METHODS: A total of ten patients underwent a local tumescent liposuction procedure to remove approximately 100 ml of fat tissue from the abdomen...
June 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28627937/the-safety-of-intra-articular-injections-for-the-treatment-of-knee-osteoarthritis-a-critical-narrative-review
#2
Christelle Nguyen, François Rannou
International guidelines recommend that the management of knee osteoarthritis (OA) combine both nonpharmacological and pharmacological interventions. Intra-articular (IA) therapies are considered part of this multimodal approach and are well-established Food and Drug Administration (FDA) and European Medicines Agency (EMA)-approved treatments. Areas covered. Safety data for knee OA, including IA corticosteroids, hyaluronic acid, platelet-rich plasma and botulinum toxin are critically reviewed, and evidence- and pratice-based measures to improve safety of IA therapies are discussed...
June 19, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28608754/a-preliminary-study-comparing-microfracture-and-local-adherent-transplantation-of-autologous-adipose-derived-stem-cells-followed-by-intraarticular-injection-of-platelet-rich-plasma-for-the-treatment-of-chondral-defects-in-rabbits
#3
Timea Spakova, Judita Amrichova, Jana Plsikova, Denisa Harvanova, Slavomir Hornak, Valent Ledecky, Jan Rosocha
Objective This study aimed to compare microfracture and application of adipose-derived stem cells (ADSCs) by local adherent technique enhanced by platelet-rich plasma (PRP) to provide a new approach for the repair of cartilage defect. Design Full-thickness cylindrical defects were created in the medial femoral condyle in 9 New Zealand White rabbits (5 months old, 4.65 ± 0.20 kg). Two groups of rabbits ( n = 3) were either treated with ADSCs (Group 1) or the microfracture technique (Group 2) following intraarticular injection of PRP 3 times in weekly intervals...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28603367/effect-of-platelet-concentration-on-clinical-improvement-in-treatment-of-early-stage-knee-osteoarthritis-with-platelet-rich-plasma-concentrations
#4
Bahar Dernek, Fatma Nur Kesiktas, Tahir Mutlu Duymus, Tugba Aydin, Nilgun Isiksacan, Demirhan Diracoglu, Cihan Aksoy
[Purpose] To compare two platelet-rich plasma kits with different platelet concentrations for treatment of knee osteoarthritis. [Subjects and Methods] Male and female patients with knee osteoarthritis who had confirmed diagnosis with X-ray and magnetic resonance imaging were included in this retrospective study. Eligible patients were divided into two groups: Group I, which received platelet-rich plasma kit I, and Group II, which received platelet-rich plasma kit II. Platelet concentrations of both kits were measured by manual counting...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28602048/injected-corticosteroids-for-treating-plantar-heel-pain-in-adults
#5
REVIEW
Judy A David, Venkatesan Sankarapandian, Prince Rh Christopher, Ahana Chatterjee, Ashish S Macaden
BACKGROUND: Plantar heel pain, commonly resulting from plantar fasciitis, often results in significant morbidity. Treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), orthoses, physical therapy, physical agents (e.g. extracorporeal shock wave therapy (ESWT), laser) and invasive procedures including steroid injections. OBJECTIVES: To assess the effects (benefits and harms) of injected corticosteroids for treating plantar heel pain in adults. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials (the Cochrane Library), MEDLINE, Embase, CINAHL, clinical trials registries and conference proceedings...
June 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28590091/an-update-on-the-protocols-and-biologic-actions-of-platelet-rich-fibrin-in-dentistry
#6
Rucha Shah, Triveni M G, Raison Thomas, Dhoom Singh Mehta
Platelet rich fibrin (PRF) is a surgical biologic additive that is prepared by manipulation of autologous blood. It has now evolved to become one of the most widely used platelet concentrate in dentistry. It has almost replaced Platelet rich plasma (PRP) for usage owing to its advantages such as being 100% autogenous, easy technique, time and cost effectiveness, superior & prolonged growth factor release. It finds varied applications in dentistry including management of gingival recession, for guided bone regeneration in periodontal, peri-implant and endodontic bone defects...
June 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28584745/autologous-platelet-rich-plasma-versus-corticosteroid-in-the-management-of-elbow-epicondylitis-a-randomized-study
#7
Ankit Varshney, Rajesh Maheshwari, Anil Juyal, Atul Agrawal, Prabhnoor Hayer
INTRODUCTION: Elbow epicondylar tendinitis is a common problem for patients whose activities require strong gripping or repetitive wrist movements in the day-to-day activities of life. Histologic specimens from chronic cases confirm that tendinitis is not an acute inflammatory condition but rather a failure of the normal tendon repair mechanism associated with angiofibroblastic degeneration. Tendon regeneration may be improved by injecting autologous growth factors obtained from the patient's own blood...
April 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28577784/autologous-blood-and-platelet-rich-plasma-injections-for-treatment-of-lateral-epicondylitis
#8
REVIEW
James H Calandruccio, Murphy M Steiner
Lateral epicondylitis (tennis elbow) is a frequent cause of elbow pain; most patients (80%-90%) are successfully treated with standard nonoperative methods (rest, nonsteroidal anti-inflammatory drugs, bracing, and physical therapy). Autologous blood injections and platelet-rich plasma injections are the two most frequently used orthobiologic techniques in the treatment of lateral epicondylitis. Studies of the effectiveness of autologous blood injections and platelet-rich plasma report varying outcomes, some citing significant clinical relief and others reporting no beneficial effect...
July 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28567426/treatment-of-subacromial-impingement-syndrome-platelet-rich-plasma-or-exercise-therapy-a-randomized-controlled-trial
#9
Parisa Nejati, Armita Ghahremaninia, Farrokh Naderi, Safoora Gharibzadeh, Ali Mazaherinezhad
BACKGROUND: Subacromial impingement syndrome (SAIS) is the most common disorder of the shoulder. The evidence for the effectiveness of treatment options is inconclusive and limited. Therefore, there is a need for more evidence in this regard, particularly for long-term outcomes. HYPOTHESIS: Platelet-rich plasma (PRP) would be an effective method in treating subacromial impingement. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28566783/a-comparative-study-to-evaluate-the-efficacy-of-platelet-rich-plasma-and-triamcinolone-to-treat-tennis-elbow
#10
Vanamali B Seetharamaiah, Amrit Gantaguru, Sunil Basavarajanna
BACKGROUND: Lateral elbow pain is common with a population prevalence of 1%-3%. The study was a comparative trial to validate the efficacy of single injection of platelet-rich plasma (PRP) for tennis elbow as compared with single injections of triamcinolone and placebo (normal saline) over a short term period. MATERIALS AND METHODS: Comparative trial with 3- and 6-month followup evaluated with visual analog scale (VAS) and facial pain scale (FPS). Our study included a total of eighty patients with unilateral or bilateral tennis elbows...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28546769/treatment-of-chronic-low-back-pain-new-approaches-on-the-horizon
#11
REVIEW
Nebojsa Nick Knezevic, Shane Mandalia, Jennifer Raasch, Ivana Knezevic, Kenneth D Candido
Back pain is the second leading cause of disability among American adults and is currently treated either with conservative therapy or interventional pain procedures. However, the question that remains is whether we, as physicians, have adequate therapeutic options to offer to the patients who suffer from chronic low back pain but fail both conservative therapy and interventional pain procedures before they consider surgical options such as discectomy, disc arthroplasty, or spinal fusion. The purpose of this article is to review the potential novel therapies that are on the horizon for the treatment of chronic low back pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28530451/effect-of-high-volume-injection-platelet-rich-plasma-and-sham-treatment-in-chronic-midportion-achilles-tendinopathy-a-randomized-double-blinded-prospective-study
#12
Anders Ploug Boesen, Rudi Hansen, Morten Ilum Boesen, Peter Malliaras, Henning Langberg
BACKGROUND: Injection therapies are often considered alongside exercise for chronic midportion Achilles tendinopathy (AT), although evidence of their efficacy is sparse. PURPOSE: To determine whether eccentric training in combination with high-volume injection (HVI) or platelet-rich plasma (PRP) injections improves outcomes in AT. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 60 men (age, 18-59 years) with chronic (>3 months) AT were included and followed for 6 months (n = 57)...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28526154/an-analysis-of-new-approaches-and-drug-formulations-for-treatment-of-chronic-low-back-pain
#13
REVIEW
Karishma Patel Bhangare, Alan D Kaye, Nebojsa Nick Knezevic, Kenneth D Candido, Richard D Urman
The prevalence of chronic low back pain (CLBP) is increasing. Treatment is effective in less than 50% of patients after 1 year. This review investigates new treatments for CLBP. An extensive literature review focuses on new treatments for CLBP. Their safety and efficacy were evaluated and are described in detail in this review. The investigation identified new treatments for CLBP including chemonucleolysis, platelet-rich plasma injections, artemin, tanezumab, and stem cells. Further research and innovation are needed to implement these methods into practice and assess clinical significance...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28523446/in-vitro-quantification-of-luminal-denudation-after-crimping-and-balloon-dilatation-of-endothelialized-covered-stents
#14
Shigeo Ichihashi, Frederic Wolf, Thomas Schmitz-Rode, Kimihiko Kichikawa, Stefan Jockenhoevel, Petra Mela
PURPOSE: Covered stents have been demonstrated to reduce restenosis; however, the membrane's limited biocompatibility can still lead to thrombus formation. To obtain optimal surface hemocompatibility, endothelialization of the luminal surface has been proposed. However, the effect of delivery procedures, such as crimping and balloon dilatation, on the endothelial layer has not been quantified. This study investigated the impact of such procedures on endothelialized covered stents in vitro...
May 18, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28509340/prf-based-matrices-to-improve-angiogenesis-in-an-in-vitro-co-culture-model-for-bone-tissue-engineering
#15
Eva Dohle, Karima El Bagdadi, Robert Sader, Joseph Choukroun, C James Kirkpatrick, Shahram Ghanaati
In the context of prevascularization strategies for tissue engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence repair processes like wound healing or angiogenesis. The development of autologous injectable platelet rich fibrin (PRF), which can be generated from peripheral blood in a minimal invasive procedure, fulfils several requirements for clinically applicable cell-based tissue engineering strategies...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28504480/therapeutic-effect-of-microneedling-and-autologous-platelet-rich-plasma-in-the-treatment-of-atrophic-scars-a-randomized-study
#16
Zeinab A Ibrahim, Amal A El-Ashmawy, Ola A Shora
BACKGROUND: New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects. AIM OF THE WORK: The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination of both procedures in the treatment of atrophic scars. PATIENTS AND METHODS: This study included 90 patients with atrophic scars and were classified randomly into three groups: I: 28 patients treated with microneedling, one session every 4 weeks; II: 34 patients treated with intradermal injection of platelet-rich plasma, one session every 2 weeks; and III: 28 patients treated with alternative sessions of each microneedling and platelet-rich plasma, 2 weeks between each session, for a maximum of six sessions...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28503741/the-effect-of-autologous-activated-platelet-rich-plasma-injection-on-female-pattern-hair-loss-a-randomized-placebo-controlled-study
#17
Abeer Attia Tawfik, Mai Abdel Raouf Osman
BACKGROUND: Hair is an essential part of a woman's appearance and attractiveness. This is reflected in the predominantly psychological morbidity that can be associated with female pattern hair loss. Platelet-rich plasma(PRP) has been used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. OBJECTIVE: To evaluate the efficacy and safety of autologous platelet-rich plasma in the treatment of female pattern hair loss...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28498138/epidural-injection-of-platelet-rich-plasma-for-postlumbar-puncture-headaches
#18
Adnan I Qureshi, Asad Ahrar, Vikram Jadhav, Shawn S Wallery
No abstract text is available yet for this article.
May 11, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28476542/short-term-clinical-results-of-intra-articular-prp-injections-for-early-osteoarthritis-of-the-knee
#19
Po-Hua Huang, Ching-Jen Wang, Wen-Yi Chou, Jun-Wen Wang, Jih-Yang Ko
PURPOSE: To assess the short-term results of repeated intra-articular platelet rich plasma (PRP) injections into the knee in patients with early osteoarthritis (OA) and to determine a better treatment protocol. METHODS: This is a retrospective study in 191 knees (127 patients) with minimum of 12 months follow-up. We compared the clinical results of three types of injection method, once a month, twice monthly, and three injections at monthly interval. The outcomes were assessed using Visual Rating Scale (VRS), functional score, knee score, range of motion (ROM), WOMAC Stiffness/Pain/Function score, IKDC score, before the first injection and at 12 months post treatment...
June 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28470911/platelet-rich-plasma-for-chronic-synovitis-treatment-in-patients-with-haemophilia
#20
H Caviglia, M E Landro, C Daffunchio, G Galatro, A L Douglas Price, P Salgado, D Neme
INTRODUCTION: Haemophilic synovitis is caused by chronic accumulation of blood in the joint. Conservative treatment is insufficient to solve this pathology. Platelet-rich plasma (PRP) has a high concentration of growth factors (GFs) that play a key role in regulation and stimulation of healing processes. The aim of this study was to describe the effect of PRP injection in chronic synovitis of the joints in patients with haemophilia (PWH). PATIENTS AND METHODS: Nineteen patients with 28 joints were treated at our centre in Buenos Aires, Argentina between December 2014 and December 2015...
May 4, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
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