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Platelet rich plasma injection

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https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#1
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29906391/enhanced-rotator-cuff-repair-using-platelet-rich-plasma-adsorbed-on-branched-poly-ester-urea-s
#2
Erin P Childers, Nathan Z Dreger, Alex B Ellenberger, Mary Beth Wandel, Karen Domino, Yanyi Xu, Derek Luong, Jiayi Yu, David Orsini, Robert H Bell, Christopher Premanandan, Stephen D Fening, Matthew L Becker
Platelet-rich plasma (PRP) is a clinically relevant source of growth factors used commonly by surgeons. The clinical efficacy of PRP use as reported in the literature is widely variable which is likely attributed to poorly defined retention time of PRP at the repair site. To overcome this limitation, branched poly(ester urea) (PEU) nanofibers were used to adsorb and retain PRP at the implant site in an acute rotator-cuff tear model in rats. The adsorption of PRP to branched-PEU was characterized using quartz crystal microbalance (QCM) and immuno-protein assay...
June 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29905053/-effect-of-human-adipose-derived-stem-cells-on-pressure-ulcer-healing-in-mouse
#3
Chengliang Deng, Zhiyuan Liu, Yuanzhen Yao, Ruichi Liu, Zairong Wei, Dali Wang
Objective: To investigate the effect of human adipose-derived stem cells (hADSCs) on pressure ulcers in mouse. Methods: The subcutaneous adipose tissue from voluntary donation was harvested. Then the hADSCs were isolated and cultured by mechanical isolation combined with typeⅠcollagenase digestion. The 3rd generation cells were identified by osteogenic, adipogenic, chondrogenic differentiations and flow cytometry. The platelet rich plasma (PRP) from peripheral blood donated by healthy volunteers was prepared by centrifugation...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904992/platelet-rich-plasma-for-the-management-of-hair-loss-better-alone-or-in-combination
#4
Eduardo Anitua, Ander Pino, Pedro Jaén, Mª Rogelia Navarro
Platelet-rich plasma (PRP) and autologous protein-based treatments have recently emerged as a potential therapeutic approach for hair loss-related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs...
June 14, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29900994/comparison-of-effects-of-leukocyte-rich-and-leukocyte-poor-platelet-rich-plasma-on-pain-and-functionality-in-patients-with-lateral-epicondylitis
#5
Melek Yerlikaya, Havva Talay Çaliş, Serap Tomruk Sütbeyaz, Hatice Sayan, Nurdan Ibiş, Ali Koç, Çiğdem Karakükçü
Objectives: This study aims to compare the effect of leukocyte concentration in platelet-rich plasma (PRP) on pain, functionality and post-injection local inflammatory reactions in patients with lateral epicondylitis. Patients and methods: The study included 90 patients (26 males, 64 females; mean age 38.6 years; range 18 to 75 years) with lateral epicondylitis- related pain visual analog scale (VAS) score of ≥5 for more than three months. Patients were randomly assigned into three groups...
March 2018: Archives of rheumatology
https://www.readbyqxmd.com/read/29896019/osteochondritis-dissecans-does-platelet-rich-plasma-really-help
#6
Deepak Kumar Sharma, Narendra Kumar, Hitesh Lal, Binay Kumar Sahu, Sumon Singphow Saikia
Osteochondritis dissecans is a common disorder of knee and can be treated by various methods, depending on age of patient and stability of chondral fragment. In Osteochondritis dissecans ICRS type III lesion i.e. articular cartilage discontinuity but no dislocation, variable rate of union as well as high rate of non-union was observed in previous studies when treated with arthroscopic or open reduction and fixation. In previous study it has been also shown that platelet rich plasma help in fracture healing...
April 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29892605/subcutaneous-administration-of-low-molecular-weight-heparin-to-horses-inhibits-ex-vivo-equine-herpesvirus-type-1-induced-platelet-activation
#7
Tracy Stokol, Priscila B S Serpa, Marjory B Brooks, Thomas Divers, Sally Ness
Equine herpesvirus type 1 (EHV-1) is a major cause of infectious respiratory disease, abortion and neurologic disease. Thrombosis in placental and spinal vessels and subsequent ischemic injury in EHV-1-infected horses manifests clinically as abortion and myeloencephalopathy. We have previously shown that addition of heparin anticoagulants to equine platelet-rich plasma (PRP) can abolish ex vivo EHV-1-induced platelet activation. The goal of this study was to test whether platelets isolated from horses treated with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) were resistant to ex vivo EHV-1-induced activation...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29883240/the-use-of-platelet-rich-plasma-prp-to-improve-structural-impairment-of-rat-testis-induced-by-busulfan
#8
Farzaneh Dehghani, Narges Sotoude, Hossein Bordbar, M R Panjeshahin, Saied Karbalay-Doust
Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into four groups. Infertility was induced by the administration of busulfan (BUS) (10mg/kg, I.P., single dose). PRP (80μl, testis local injected, single dose) was administered for the subjects. After 48 days, semen analysis was performed and blood samples were taken from the heart to measure the testosterone...
June 8, 2018: Platelets
https://www.readbyqxmd.com/read/29881226/the-use-of-platelet-rich-fibrin-with-platelet-rich-plasma-support-meniscal-repair-surgery
#9
Masahiko Kemmochi, Shigeru Sasaki, Masako Takahashi, Tomitaka Nishimura, Chisa Aizawa, Jun Kikuchi
Introduction: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. Materials and Methods: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29878617/clinical-outcomes-are-associated-with-changes-in-ultrasonographic-structural-appearance-after-platelet-rich-plasma-treatment-for-knee-osteoarthritis
#10
Hamada S Ahmad, Sherief E Farrag, Amr E Okasha, Aisha O Kadry, Tamer B Ata, Amir A Monir, Ibrahim Shady
BACKGROUND: Hyaluronic acid (HA) and platelet-rich plasma (PRP) are two treatment options used for knee osteoarthritis (KOA) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of PRP intra-articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated. AIM: To compare the efficacy of PRP and HA intra-articular injections as mono-therapeutic options for primary KOA, and to determine whether the clinical outcomes are associated with changes in the ultrasonography structural appearance...
May 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29869472/-injection-of-prp-platelet-rich-plasma-as-a-treatment-for-androgenetic-alopecia-a-systematic-review-of-the-literature
#11
REVIEW
O Oth, J-J Stene, R Glineur, A Vujovic
INTRODUCTION: Androgenetic alopecia is the most frequent alopecia both in men and women. Despite it affects a large proportion of the population, they are few therapeutic options often restrictive. The injection of PRP in alopecic areas is a new and easy therapeutic option. The aim of this article is to systematically review the literature about this topic by analysing the articles describing the clinical results of this new technique in the treatment of androgenetic alopecia in men and / or women with a follow-up of minimum 6 months...
May 30, 2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29868619/ultrasonographic-findings-in-41-dogs-treated-with-bone-marrow-aspirate-concentrate-and-platelet-rich-plasma-for-a-supraspinatus-tendinopathy-a-retrospective-study
#12
Renee A McDougall, Sherman O Canapp, Debra A Canapp
Objective: To report sonographic findings for dogs with a supraspinatus tendinopathy (ST) treated with an ultrasound-guided intratendinous injection of bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP). Methods: Medical records for dogs diagnosed with an ST and treated with a BMAC-PRP injection were reviewed. Data collected included patient signalment, radiographic findings at the time of initial evaluation, and sonographic findings, including cross-sectional area (CSA), fiber pattern, and echogenicity...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29849470/systematic-clinical-evidence-review-of-nasha-durolane-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#13
REVIEW
Ross Leighton, Jane Fitzpatrick, Helen Smith, Daniela Crandall, Carl R Flannery, Thierry Conrozier
Background: Pain and limitations in joint mobility associated with knee osteoarthritis (OA) are clinically challenging to manage, and advanced progression of disease can often lead to total knee arthroplasty. Intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation, is a non-surgical treatment approach for OA, the effectiveness of which may depend on the HA composition, and the length of time over which it resides in the joint. One of the available options for such therapies includes NASHA (Durolane HA), a non-animal, biofermentation-derived product, which is manufactured using a process that stabilizes the HA molecules to slow down their rate of degradation and produce a unique formulation with a terminal half-life of ~1 month...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29844536/injectable-cartilaginous-template-transformed-bmscs-into-vascularized-bone
#14
Xiaoke Feng, Zhiye Li, Jianhua Wei, Zhihong Feng, Wei Wu, Yimin Zhao
Regeneration of alveolar bone for dental implant remains a major issue, partifcularly for patients suffering from severe bone adsorption and irregular socket trauma. Recapitulating embryological development is becoming an attractive approach for engineer organ or three-dimensional tissues from stem cells. In this study, we aimed to develop an injectable "cartilaginous" graft with adequate mechanical resistance and ideal bone remodelling potential. The cartilaginous graft was composed of a particulate decellularised cartilage matrix (PDCM), chondrogenically primed bone mesenchymal stem cell (BMSC) bricks (CB), and enriched platelet-rich plasma (P) gel...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29806425/-effect-of-intra-articular-injection-of-platelet-rich-plasma-on-interleukin-17-expression-in-synovial-fluid-and-venous-plasma-of-knee-osteoarthritis-patients
#15
Haisen Zhang, Yuming Bai, Chang Liu, Shengli Jin, Ke Su, Ying Liu, Zhichang Lü
Objective: To investigate the interleukin-17 (IL-17) levels changes in both synovial fluid and venous plasma of patients with primary knee osteoarthritis (OA) after intra-articular injection of platelet-rich plasma (PRP). Methods: Between January 2015 and January 2016, 30 patients with primary knee OA were treated by intra-articular injection of PRP once a week for 3 weeks (trial group). Thirty healthy individuals were recruited into the study as control. There was no significant difference in gender, age, and body mass index between 2 groups ( P >0...
August 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29803229/anterior-disc-derangement-with-reduction-of-the-temporomandibular-joint-a-case-report
#16
Katie L Crockett, Richard Bourassa, Tyler Friesen
BACKGROUND: Temporomandibular dysfunction involving anterior disc derangement with or without reduction, secondary to posterior ligament insufficiency is typically managed conservatively with success in a majority of patients. When conservative management fails, the next step in the continuum of care is unclear. Platelet-rich plasma injection combined with a 3-week immobilization period may be effective in treating posterior ligament insufficiency following a period of physical therapy...
May 27, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29803179/platelet-rich-plasma-stromal-vascular-fraction-and-autologous-conditioned-serum-in-treatment-of-knee-osteoarthritis
#17
REVIEW
Ali Fotouhi, Arash Maleki, Sanam Dolati, Ali Aghebati-Maleki, Leili Aghebati-Maleki
Osteoarthritis (OA) is a multifactorial chronic disease, causing several problems on patients, hygiene and community care systems. Conventional therapies, such as non-pharmacological mediations, systemic drug treatment and intra-articular therapies are applying previously; however, controlling and management approaches of the disease mainly remain insufficient. Injections of intra-articular therapies directly into the joint evade conservative obstacles to joint entry, rise bioavailability and minor systemic toxicity...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29798102/-experimental-study-of-using-chitosan-nerve-conduit-combined-with-prp-to-repair-facial-nerve-defect
#18
H B Lu, Y S Jia, X L Guo, H Yu, S J Wu
Objective: The purpose of this study was to produce chitosan nerve conduit in order to investigate the feasibility of chitosan nerve conduit combined with autologous platelet-rich plasma (PRP) for repairing facial nerve defects. Method: Forty New Zealand white rabbits were randomly divided into four groups (n=10 in each group).Establishment of the facial nerve defect model of the upper buccal branches was placed in the nerve regeneration catheter and injected with the same amount of PRP and saline. The PRP was injected into the chitosan nerve conduit as group A...
October 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29790267/systematic-review-of-platelet-rich-plasma-prp-preparation-and-composition-for-the-treatment-of-androgenetic-alopecia
#19
REVIEW
MaryJo E Kramer, Terrence C Keaney
BACKGROUND: Platelet-rich plasma (PRP) injections have gained popularity in dermatology practice as a treatment for hair loss. As an autologous blood product, PRP is categorized as a minimally manipulated tissue by the U.S. Food and Drug Administration (FDA) and thus evades extensive regulation. As a result, there is a lack of standardization of its preparation and final composition. OBJECTIVE: This study aims to provide a systematic review of the various PRP preparation protocols and PRP compositions utilized in clinical trials for the treatment of hair loss...
May 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29785224/pseudarthrosis-of-the-calcaneus-advantages-of-regenerative-medicine-in-the-management-of-a-rare-entity-a-case-report-and-review-of-literature
#20
Bouaziz Wajdi, Mohamed Ali Rebai, Walid Baya, Nabil Krid, Wassim Zribi, Hassib Keskes
Background: The follow-up of calcaneal fractures has shown that they are difficult to manage and lead to multiple complications such as malunion and subtalar osteoarthritis. Pseudarthrosis of the calcaneus is an extremely rare complication, which was described in the literature through case reports.In the existing literature, only seven studies, including thirteen patients have reported the nonunion. However, to the best of our knowledge, no study elucidates the role of new techniques of regenerative medicine such as Bone Marrow Concentrates (BMC) or Platelet Rich Plasma (PRP) in the management...
2018: Open Orthopaedics Journal
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