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Platelet rich plasma injection

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https://www.readbyqxmd.com/read/28806095/a-midterm-evaluation-of-postoperative-platelet-rich-plasma-injections-on-arthroscopic-supraspinatus-repair-a-randomized-controlled-trial
#1
Jay R Ebert, Allan Wang, Anne Smith, Robert Nairn, William Breidahl, Ming Hao Zheng, Timothy Ackland
BACKGROUND: Platelet-rich plasma (PRP) has been applied as an adjunct to rotator cuff repair to improve tendon-bone healing and potentially reduce the incidence of subsequent tendon retears. PURPOSE: To investigate whether the midterm clinical and radiographic outcomes of arthroscopic supraspinatus repair are enhanced after repeated postoperative applications of PRP. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 60 patients (30 control; 30 PRP) were initially randomized to receive 2 ultrasound-guided injections of PRP to the tendon repair site at 7 and 14 days after double-row arthroscopic supraspinatus repair or not...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28803906/viscosupplementation-for-hip-osteoarthritis-a-systematic-review-and-meta-analysis-of-the-efficacy-for-pain-disability-and-adverse-events
#2
REVIEW
Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler
OBJECTIVE: To assess the efficacy of viscosupplementation (HA) in hip osteoarthritis (OA) pain, disability and adverse events. DATA SOURCES: Pubmed, EMBASE, Cochrane Library, ClinicalTrials.gov database and specific journals up to March 2017. STUDY SELECTION: Randomized controlled trials comparing HA with any other intra-articular injection. DATA EXTRACTION: Performed according to Cochrane/GRADE criteria. Two authors extracted data, assessed risk of bias and quality of evidence...
August 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28800920/does-platelet-rich-plasma-lead-to-earlier-return-to-sport-when-compared-with-conservative-treatment-in-acute-muscle-injuries-a-systematic-review-and-meta-analysis
#3
Ujash Sheth, Tim Dwyer, Ira Smith, David Wasserstein, John Theodoropoulos, Sachdeep Takhar, Jaskarndip Chahal
PURPOSE: To compare the time to return to sport and reinjury rate after platelet-rich plasma (PRP) injection versus control therapy (i.e., physiotherapy or placebo injection) in patients with acute grade I or II muscle strains. METHODS: All eligible studies comparing PRP against a control in the treatment of acute (≤7 days) grade I or II muscle strains were identified. The primary outcome was time to return to play. The secondary outcome was the rate of reinjury at a minimum of 6 months of follow-up...
August 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28798878/treatment-of-knee-osteochondral-lesions-using-a-novel-clot-of-autologous-plasma-rich-in-growth-factors-mixed-with-healthy-hyaline-cartilage-chips-and-intra-articular-injection-of-prgf
#4
Ramón Cugat, Eduard Alentorn-Geli, Gilbert Steinbacher, Pedro Álvarez-Díaz, Xavier Cuscó, Roberto Seijas, David Barastegui, Jordi Navarro, Patricia Laiz, Montserrat García-Balletbó
Knee cartilage or osteochondral lesions are common and challenging injuries. To date, most symptomatic lesions warrant surgical treatment. We present two cases of patients with knee osteochondral defects treated with a one-step surgical procedure consisting of an autologous-based matrix composed of healthy hyaline cartilage chips, mixed plasma poor-rich in platelets clot, and plasma rich in growth factors (PRGF). Both patients returned to playing soccer at the preinjury activity level and demonstrated excellent defect filling in both magnetic resonance imaging and second-look arthroscopy (in one of them)...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28792974/implicit-hype-representations-of-platelet-rich-plasma-in-the-news-media
#5
Christen Rachul, John E J Rasko, Timothy Caulfield
Platelet Rich Plasma (PRP) has gained popularity in recent years for treating sports-related injuries and the news media frequently reports on elite athletes' and celebrities' use of PRP. We conducted a content analysis of newspaper coverage of PRP in Australia, Canada, Ireland, New Zealand, United Kingdom, and the United States. Findings show that news media coverage of PRP appears most frequently in sports-related stories, and in relation to elite athletes use of PRP. PRP injections are largely portrayed as a routine treatment for sports-related injuries and newspaper articles rarely discuss the limitations or efficacy of PRP...
2017: PloS One
https://www.readbyqxmd.com/read/28771982/original-article-platelet-rich-plasma-with-microneedling-in-androgenetic-alopecia-along-with-dermoscopic-pre-and-post-treatment-evaluation
#6
Abhijeet Kumar Jha, Uday Kumar Udayan, Prasoon Kumar Roy, Amar Kant Jha Amar, R K P Chaudhary
BACKGROUND: Platelet-rich plasma has shown beneficial effects in the treatment of androgenic alopecia with its growth factor properties in accelerating the dermal papilla. Dermoscopy is a noninvasive method that allows the in vivo evaluation of microstructures not visible to the naked eye. OBJECTIVE: To ascertain the role of platelet-rich plasma (PRP) with microneedling, and to compare the pre- and post-treatment dermoscopic features in androgenetic alopecia. (AGA)...
August 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28760127/does-platelet-rich-plasma-have-a-favorable-effect-in-the-early-stages-of-steroid-associated-femoral-head-osteonecrosis-in-a-rabbit-model
#7
Mustafa Karakaplan, Deniz Gülabi, Haldun Topgül, Nurzat Elmalı
OBJECTIVES: This study aims to investigate the effect of platelet-rich plasma (PRP) on femoral head osteonecrosis and compare it with bone marrow injection and core decompression. MATERIALS AND METHODS: A total of 30 healthy, adult, male New Zealand white rabbits (mean weight 2.25±0.15 kg; range 2.0 to 2.5 kg) were used in the study. To create experimental osteonecrosis in all rabbits, 40 mg/kg methylprednisolone acetate was applied intramuscularly. Rabbits were randomly allocated into three groups with 10 rabbits in each: drilling group, PRP group, and bone marrow group...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28760125/comparison-of-the-effects-of-human-recombinant-epidermal-growth-factor-and-platelet-rich-plasma-on-healing-of-rabbit-patellar-tendon
#8
Baran Sarıkaya, Nihat Yumuşak, Akın Yigin, Serkan Sipahioğlu, Ünal Yavuz, Mehmet Akif Altay
OBJECTIVES: This study aims to compare the histological healing process and gene expression profile in tendon after the administration of human recombinant epidermal growth factor (hrEGF) and platelet-rich plasma (PRP). MATERIALS AND METHODS: A total of 24 mature New Zealand white rabbits (6-month-old; weight 2.5-3.0 kg) were used in the study. Patellar tendons of rabbits were tenotomized and then repaired. Rabbits were separated into three groups and repair areas were injected with 1 mL hrEGF in group 1 (n=9) and 1 mL PRP in group 2 (n=9)...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28759287/the-use-of-platelet-rich-plasma-to-treat-chronic-tendinopathies-a-technical-analysis
#9
Jean-François Kaux, Thibault Emonds-Alt
Platelet-rich plasma (PRP) is blood plasma with a high concentration of autologous platelets which constitute an immense reservoir of growth factors. The clinical use of PRP is widespread in various medical applications. Although highly popular with athletes, the use of PRP for the treatment of tendinopathies remains scientifically controversial, particularly due to the diversity of products that go by the name of "PRP." To optimize its use, it is important to look at the various stages of obtaining PRP. In this literature review, we take a closer look at eight parameters which may influence the quality of PRP: 1) anticoagulants used to preserve the best platelet function, 2) the speed of centrifugation used to extract the platelets, 3) the platelet concentrations obtained, 4) the impact of the concentration of red and while blood cells on PRP actions, 5) platelet activators encouraging platelet degranulation and, hence, the release of growth factors, and 6) the use or nonuse of local anesthetics when carrying out infiltration...
July 31, 2017: Platelets
https://www.readbyqxmd.com/read/28755243/treatment-of-transsphincteric-fistula-in-ano-with-growth-factors-from-autologous-platelets-results-of-a-phase-ii-clinical-trial
#10
F de la Portilla, J J Segura-Sampedro, M L Reyes-Díaz, M V Maestre, A M Cabrera, R M Jimenez-Rodríguez, J M Vázquez-Monchul, J M Diaz-Pavón, F J Padillo-Ruiz
PURPOSE: The aim of this paper is to evaluate to the safety, feasibility and efficacy of a novel treatment for transsphincteric cryptoglandular fistula: injection of autologous plasma rich in growth factors (PRGF) into the fistula tract accompanied by sealing using a fibrin plug created from the activated platelet-poor fraction of the same plasma. METHOD: This article is a prospective, phase II clinical trial. The procedure was externally audited. Thirty-six patients diagnosed with transsphincteric fistula-in-ano were included...
July 29, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28752097/efficacy-of-platelet-rich-plasma-in-retarding-intervertebral-disc-degeneration-a-meta-analysis-of-animal-studies
#11
Pei Li, Ruijie Zhang, Qiang Zhou
OBJECTIVES: Several animal studies have demonstrated the positive effects of platelet-rich plasma (PRP) on disc degeneration retardation. The present meta-analysis was to verify the efficacy of PRP in retarding disc degeneration in animal. METHODS: Relevant studies were identified and evaluated according to our inclusion and exclusion criteria. The standardized mean difference (SMD) and related 95% confidence interval (95% CI) were estimated to assess PRP efficiency...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28745776/aryepiglottic-fold-augmentation-as-treatment-for-late-onset-dysphagia-following-surgical-treatment-of-recurrent-laryngeal-neuropathy
#12
Aleksandar Vidovic, Uta Delling
OBJECTIVE: Coughing and dysphagia have been described following prosthetic laryngoplasty (LP) with or without ventriculectomy/ventriculocordectomy (VE/VCE) for the treatment of recurrent laryngeal neuropathy. All previous case descriptions include patients with acute onset of clinical signs after surgery that persisted. The authors observed a late-onset of dysphagia and coughing months to years after LP ± VE/VCE. The condition was always associated with an abnormality of the aryepiglottic fold (AEF)...
July 26, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28721121/does-the-injection-of-platelet-rich-plasma-induce-changes-in-the-gene-expression-and-morphology-of-intact-thoroughbred-skeletal-muscle
#13
Kentaro Fukuda, Hirofumi Miyata, Atsutoshi Kuwano, Taisuke Kuroda, Norihisa Tamura, Yasumitsu Kotoyori, Yoshinori Kasashima
Platelet-rich plasma (PRP) therapy is promising for treating skeletal muscle injuries in human athletes by promoting muscle regeneration. It might also be useful for treating muscle injuries in equine athletes. In the present study, muscle regeneration induced by injection of PRP into intact muscle of Thoroughbred was investigated. Autologous PRP and saline were injected twice into intact left and right gluteus medius muscles of seven clinically healthy Thoroughbreds. Muscle samples were collected from the injection sites by needle biopsy at 2 and 7 days after PRP injection...
2017: Journal of Equine Science
https://www.readbyqxmd.com/read/28719231/biologic-injections-for-osteoarthritis-and-articular-cartilage-damage-can-we-modify-disease
#14
Weilong J Shi, Fotios P Tjoumakaris, Mayan Lendner, Kevin B Freedman
OBJECTIVE: The purpose of the present investigation is to conduct a systematic review of the literature to review the clinical results of platelet rich plasma (PRP) and mesenchymal stem cell treatments (MSC) (biologics) for articular cartilage lesions and osteoarthritis of the knee. METHODS: A search of the PubMed, EMBASE, and Cochrane databases was performed to identify studies involving biologic therapy for osteoarthritis or osteochondral defects. Only Level I-III clinical trials with at least 3-month follow-up were included...
July 28, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28717617/conservative-treatment-for-insertional-achilles-tendinopathy-platelet-rich-plasma-and-focused-shock-waves-a-retrospective-study
#15
Davide Erroi, Matilde Sigona, Tania Suarez, Donatella Trischitta, Antonio Pavan, Maria Chiara Vulpiani, Mario Vetrano
BACKGROUND: Insertional Achilles tendinopathy (IAT) represents a serious challenge for both physiatrists and surgeons. Here we analyse the results obtained by two conservative treatments [platelet-rich plasma (PRP) injections and focused extracorporeal shock-wave therapy (ESWT)] in physically active patients with IAT. METHODS: During two consecutive periods, 45 consecutive patients with IAT were treated with 3 sessions of ESWT (2400 impulses at 0.17-0.25 mJ/mm(2) per session) (24 cases between September 2011 and July 2013) or with 2 autologous PRP injections over two weeks (21 cases between September 2013 and July 2015)...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28714762/effectiveness-of-prp-injection-in-reducing-recovery-time-of-acute-hamstring-injury-a-critically-appraised-topic
#16
Mary Lynn Manduca, Stephen J Straub
Clinical Scenario Hamstring strains are common athletic injuries, with a high recurrence rate (34%).(2) Recently, platelet-rich-plasma (PRP) injections have gained popularity as a potential treatment option to accelerate healing of hamstring injury.(3) Focused Clinical Question Does the combination of PRP injection and rehabilitation decrease recovery time of acute hamstring injury as compared to rehabilitation alone in collegiate athletes? Summary of Key Findings A literature search resulted in three randomized controlled trials (RCT)...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28706837/intraosseous-infiltration-of-platelet-rich-plasma-for-severe-hip-osteoarthritis
#17
Nicolás Fiz, Juan Carlos Pérez, Jorge Guadilla, Ane Garate, Pello Sánchez, Sabino Padilla, Diego Delgado, Mikel Sánchez
This work describes a technique of platelet-rich plasma (PRP) infiltration for the treatment of severe hip osteoarthritis (OA). Although the results achieved with intra-articular infiltrations of PRP are promising, they may be insufficient in the long-term for severe hip OA. The technique consists of a combined intra-articular and intraosseous infiltration of PRP to reach all joint tissues, especially the subchondral bone, and hence facilitate a greater distribution of PRP. Diagnosis is based on clinical and radiographic findings, and patients with grade III OA according to the Tönnis scale, as well as patients who have not responded to conventional treatment, are considered candidates for this technique...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28689433/experimental-and-early-investigational-drugs-for-androgenetic-alopecia
#18
REVIEW
Hongwei Guo, Wendi Victor Gao, Hiromi Endo, Kevin John McElwee
Treatments for androgenetic alopecia constitute a multi-billion-dollar industry, however, currently available therapeutic options have variable efficacy. Consequently, in recent years small biotechnology companies and academic research laboratories have begun to investigate new or improved treatment methods. Research and development approaches include improved formulations and modes of application for current drugs, new drug development, development of cell-based treatments, and medical devices for modulation of hair growth...
August 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28688621/ultrasound-guided-perineural-injection-with-platelet-rich-plasma-improved-the-neurophysiological-parameters-of-carpal-tunnel-syndrome-a-case-report
#19
Ying-Chen Kuo, Chia-Cheng Lee, Lin-Fen Hsieh
Carpal tunnel syndrome (CTS) is a common and sometimes challenging condition, which causes pain; paresthesia; tingling of the thumb, index and long fingers; and even thenar weakness in the hands. The effectiveness of corticosteroid injections seems to be transient, and there is a lack of information around long-term effects in previous studies. In recent years, platelet-rich plasma (PRP) has proven to bean alternative as it encourages tissue regeneration. We hereby describe a patient with CTS showing significant improvements in electrophysiological parameters after receiving PRP injections...
July 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28676455/injections-of-platelet-rich-plasma-for-androgenic-alopecia-a-systematic-review
#20
F Picard, B Hersant, J Niddam, J-P Meningaud
The aim of this literature review was to evaluate the effects of PRP injections into the scalp of patients with androgenic alopecia. A literature review was conducted using the Pubmed and Google Scholar databases with the search terms "platelet-rich plasma" or "platelet-rich fibrin" and "hair" or "alopecia" or "androgenic alopecia". The publications included had to clinically assess the efficacy of PRP injections in patients with androgenic alopecia. Out of the 32 publications retrieved, 14 publications were included, of which 3 randomized, 4 prospective controlled, 4 prospective uncontrolled and 3 retrospective studies...
July 1, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
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