keyword
MENU ▼
Read by QxMD icon Read
search

Cancer branched chain amino acid

keyword
https://www.readbyqxmd.com/read/28179968/the-effectiveness-of-a-liver-disease-education-class-for-providing-information-to-patients-and-their-families
#1
Yukio Kadokawa, Kazuhiro Katayama, Kozo Takahashi, Nobuhisa Fukushima, Setsu Tanaka, Yuko Taniguchi, Takatoshi Nawa, Mitsuru Sakakibara, Kazuyoshi Ohkawa
BACKGROUND: We have been conducting liver disease education classes regularly in our hospital for the purpose of providing health information to patients and their families. METHODS: In order to evaluate the effectiveness of these classes, we conducted a questionnaire survey of patients and family members who attended the classes held three times in 2012. The cumulative total number of participants was 80 (49 patients, 26 family members, and five others). The classes focused on the following areas: 1) prevention of hepatic cancer; 2) treatment of hepatic cancer; 3) iron restriction diet for hepatitis C patients; and 4) importance of branched-chain amino acid preparations...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28138303/amino-acid-profiles-of-serum-and-urine-in-search-for-prostate-cancer-biomarkers-a-pilot-study
#2
Paweł Dereziński, Agnieszka Klupczynska, Wojciech Sawicki, Jerzy A Pałka, Zenon J Kokot
There is a great interest in searching for diagnostic biomarkers in prostate cancer patients. The aim of the pilot study was to evaluate free amino acid profiles in their serum and urine. The presented paper shows the first comprehensive analysis of a wide panel of amino acids in two different physiological fluids obtained from the same groups of prostate cancer patients (n = 49) and healthy men (n = 40). The potential of free amino acids, both proteinogenic and non-proteinogenic, as prostate cancer biomarkers and their utility in classification of study participants have been assessed...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28099419/genomic-deletion-of-malic-enzyme-2-confers-collateral-lethality-in-pancreatic-cancer
#3
Prasenjit Dey, Joelle Baddour, Florian Muller, Chia Chin Wu, Huamin Wang, Wen-Ting Liao, Zangdao Lan, Alina Chen, Tony Gutschner, Yaan Kang, Jason Fleming, Nikunj Satani, Di Zhao, Abhinav Achreja, Lifeng Yang, Jiyoon Lee, Edward Chang, Giannicola Genovese, Andrea Viale, Haoqiang Ying, Giulio Draetta, Anirban Maitra, Y Alan Wang, Deepak Nagrath, Ronald A DePinho
The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of cases. As loss of neighbouring housekeeping genes can confer collateral lethality, we sought to determine whether loss of the metabolic gene malic enzyme 2 (ME2) in the SMAD4 locus would create cancer-specific metabolic vulnerability upon targeting of its paralogous isoform ME3. The mitochondrial malic enzymes (ME2 and ME3) are oxidative decarboxylases that catalyse the conversion of malate to pyruvate and are essential for NADPH regeneration and reactive oxygen species homeostasis...
February 2, 2017: Nature
https://www.readbyqxmd.com/read/28095274/protein-intake-and-breast-cancer-survival-in-the-nurses-health-study
#4
Michelle D Holmes, Jun Wang, Susan E Hankinson, Rulla M Tamimi, Wendy E Chen
Purpose Greater protein intake has been associated with better breast cancer survival in several prospective studies, including among 1,982 women in the Nurses' Health Study. We proposed to extend this previous finding. We hypothesized that protein, essential amino acid, branched-chain amino acid, and leucine intakes are associated with improved survival and that these associations are stronger in tumors expressing insulin receptor (IR). Patients and Methods We included 6,348 women diagnosed with stage I to III breast cancer between 1976 and 2004...
January 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28052414/microrna-218-inhibits-tumor-growth-and-increases-chemosensitivity-to-cddp-treatment-by-targeting-bcat1-in-prostate-cancer
#5
Wenjing Zhu, Yiqun Shao, Yu Peng
MicroRNAs have been reported to be associated with chemosensitivity of several types of cancers. However, the underlying molecular mechanisms are poorly understood. In this study, we explored miR-218 increased the chemosensitivity to cis-diaminedichloroplatinum treatment of prostate cancer. We found that the expression level of miR-218 was down-regulated in the human prostate cancer specimens. Moreover, overexpression of miR-218 inhibited cell viability, migration, and invasion in PC3 and DU145 cells. Furthermore, we demonstrated that the tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression...
January 4, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28011449/association-of-plasma-concentrations-of-branched-chain-amino-acids-with-risk-of-colorectal-adenoma-in-a-large-japanese-population
#6
S Budhathoki, M Iwasaki, T Yamaji, H Yamamoto, Y Kato, S Tsugane
BACKGROUND: Available evidence from animal studies suggests that branched-chain amino acids (BCAAs) may have a protective effect against colorectal carcinogenesis. However, a possible effect of BCAAs against colorectal neoplasia has not been evaluated in humans. Here, we aimed to evaluate whether plasma concentrations of BCAA are associated with the risk of colorectal adenoma (CRA), a precursor lesion of colorectal cancer. PATIENTS AND METHODS: Colorectal adenoma cases and controls were identified from examinees who underwent total colonoscopy as part of a cancer screening program between 2004 and 2005 and responded to self-administered dietary and lifestyle questionnaires...
December 22, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27932423/integrated-genomic-analysis-of-survival-outliers-in-glioblastoma
#7
Sen Peng, Harshil Dhurv, Brock Armstrong, Bodour Salhia, Christophe Legendre, Jeffrey Kiefer, Julianna Parks, Selene Virk, Andrew E Sloan, Quinn T Ostrom, Jill S Barnholtz-Sloan, Nhan L Tran, Michael E Berens
BACKGROUND: To elucidate molecular features associated with disproportionate survival of glioblastoma (GB) patients, we conducted deep genomic comparative analysis of a cohort of patients receiving standard therapy (surgery plus concurrent radiation and temozolomide); "GB outliers" were identified: long-term survivor of 33 months (LTS; n = 8) versus short-term survivor of 7 months (STS; n = 10). METHODS: We implemented exome, RNA, whole genome sequencing, and DNA methylation for collection of deep genomic data from STS and LTS GB patients...
December 8, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27872968/new-functions-and-potential-applications-of-amino-acids
#8
Hisayuki Uneyama, Hisamine Kobayashi, Naoto Tonouchi
Currently, several types of amino acids are being produced and used worldwide. Nevertheless, several new functions of amino acids have been recently discovered that could result in other applications. For example, oral stimulation by glutamate triggers the cephalic phase response to prepare for food digestion. Further, the stomach and intestines have specific glutamate-recognizing systems in their epithelial mucosa. Regarding clinical applications, addition of monosodium glutamate to the medicinal diet has been shown to markedly enhance gastric secretion in a vagus-dependent manner...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27770143/-1-h-nuclear-magnetic-resonance-nmr-based-serum-metabolomics-of-human-gallbladder-inflammation
#9
Raj Kumar Sharma, Kumudesh Mishra, Alvina Farooqui, Anu Behari, Vinay Kumar Kapoor, Neeraj Sinha
OBJECTIVE AND DESIGN: We present in this article (1)H nuclear magnetic resonance (NMR)-based metabolic approach to screen the serum metabolic alterations in human gallbladder inflammation with chronic cholecystitis (CC). MATERIAL/METHODS: Total of 71 human serum samples was divided into two groups, (n = 41, CC) and (n = 30 control). (1)H NMR metabolic profiling was carried out for investigation of metabolic alterations. Multivariate statistical analysis was applied for pattern recognition and identification of metabolites playing crucial role in gallbladder inflammation...
January 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27716121/leucine-rich-diet-alters-the-1-h-nmr-based-metabolomic-profile-without-changing-the-walker-256-tumour-mass-in-rats
#10
Laís Rosa Viana, Rafael Canevarolo, Anna Caroline Perina Luiz, Raquel Frias Soares, Camila Lubaczeuski, Ana Carolina de Mattos Zeri, Maria Cristina Cintra Gomes-Marcondes
BACKGROUND: Cachexia is one of the most important causes of cancer-related death. Supplementation with branched-chain amino acids, particularly leucine, has been used to minimise loss of muscle tissue, although few studies have examined the effect of this type of nutritional supplementation on the metabolism of the tumour-bearing host. Therefore, the present study evaluated whether a leucine-rich diet affects metabolomic derangements in serum and tumour tissues in tumour-bearing Walker-256 rats (providing an experimental model of cachexia)...
October 3, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27698837/bcat1-promotes-tumor-cell-migration-and-invasion-in-hepatocellular-carcinoma
#11
Meng Xu, Qingquan Liu, Yuli Jia, Kangsheng Tu, Yingmin Yao, Qingguang Liu, Cheng Guo
Branched-chain amino acid transaminase 1 (BCAT1) has been associated with numerous types of tumors; however, few previous studies have evaluated the expression and role of BCAT1 in hepatocellular carcinoma (HCC). In the present study, the expression of BCAT1 was detected by reverse transcription-quantitative polymerase chain reaction and immunoblotting in six HCC cell lines and 74 pairs of HCC and adjacent non-cancerous liver tissues. In addition, the correlation between the expression levels of c-Myc and BCAT1 was analyzed using immunohistochemistry...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27697615/integrative-transcriptomic-analysis-of-nafld-animal-model-reveals-dysregulated-genes-and-pathways-in-metabolism
#12
Wenhui Yang, Yan He, Shijie Liu, Lulu Gan, Zhiguo Zhang, Jun Wang, Jie Liang, Yang Dong, Qing Wang, Zongliu Hou, Li Yang
Dysregulation of metabolism in hepatocytes leads to hepatic diseases such as hepatitis and non-alcoholic fatty liver disease (NAFLD). NAFLD represents a spectrum of liver diseases ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). NASH is likely to progress to cirrhosis, liver failure and hepatocellular carcinoma, which lead to poor long-term prognosis. However, the exact mechanism of development of NAFLD is not well elucidated. In order to better understand the pathogenesis of NAFLD, we have performed an integrative analysis to livers from NAFLD rat models in a global view of the transcriptome...
December 20, 2016: Gene
https://www.readbyqxmd.com/read/27621572/supportive-therapies-for-prevention-of-hepatocellular-carcinoma-recurrence-and-preservation-of-liver-function
#13
REVIEW
Taro Takami, Takahiro Yamasaki, Issei Saeki, Toshihiko Matsumoto, Yutaka Suehiro, Isao Sakaida
Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world and is associated with a high risk of recurrence. The development of a wide range of new therapies is therefore essential. In this study, from the perspective of supportive therapy for the prevention of HCC recurrence and preservation of liver function in HCC patients, we surveyed a variety of different therapeutic agents. We show that branched chain amino acids (BCAA) supplementation and late evening snack with BCAA, strategies that address issues of protein-energy malnutrition, are important for liver cirrhotic patients with HCC...
August 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27609895/tissue-of-origin-dictates-branched-chain-amino-acid-metabolism-in-mutant-kras-driven-cancers
#14
Jared R Mayers, Margaret E Torrence, Laura V Danai, Thales Papagiannakopoulos, Shawn M Davidson, Matthew R Bauer, Allison N Lau, Brian W Ji, Purushottam D Dixit, Aaron M Hosios, Alexander Muir, Christopher R Chin, Elizaveta Freinkman, Tyler Jacks, Brian M Wolpin, Dennis Vitkup, Matthew G Vander Heiden
Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathways is unknown. Kras activation and Trp53 deletion in the pancreas or the lung result in pancreatic ductal adenocarinoma (PDAC) or non-small cell lung carcinoma (NSCLC), respectively, but despite the same initiating events, these tumors use branched-chain amino acids (BCAAs) differently...
9, 2016: Science
https://www.readbyqxmd.com/read/27558401/is-cancer-a-severe-delayed-hypersensitivity-reaction-and-histamine-a-blueprint
#15
Mahin Khatami
Longevity and accumulation of multiple context-dependent signaling pathways of long-standing inflammation (antigen-load or oxidative stress) are the results of decreased/altered regulation of immunity and loss of control switch mechanisms that we defined as Yin and Yang of acute inflammation or immune surveillance. Chronic inflammation is initiated by immune disruptors-induced progressive changes in physiology and function of susceptible host tissues that lead to increased immune suppression and multistep disease processes including carcinogenesis...
December 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27514531/metabolic-signatures-and-risk-of-type-2-diabetes-in-a-chinese-population-an-untargeted-metabolomics-study-using-both-lc-ms-and-gc-ms
#16
Yonghai Lu, Yeli Wang, Choon-Nam Ong, Tavintharan Subramaniam, Hyung Won Choi, Jian-Min Yuan, Woon-Puay Koh, An Pan
AIMS/HYPOTHESIS: Metabolomics has provided new insight into diabetes risk assessment. In this study we characterised the human serum metabolic profiles of participants in the Singapore Chinese Health Study cohort to identify metabolic signatures associated with an increased risk of type 2 diabetes. METHODS: In this nested case-control study, baseline serum metabolite profiles were measured using LC-MS and GC-MS during a 6-year follow-up of 197 individuals with type 2 diabetes but without a history of cardiovascular disease or cancer before diabetes diagnosis, and 197 healthy controls matched by age, sex and date of blood collection...
November 2016: Diabetologia
https://www.readbyqxmd.com/read/27447733/metabolomics-analysis-of-hormone-responsive-and-triple-negative-breast-cancer-cell-responses-to-paclitaxel-identify-key-metabolic-differences
#17
Delisha A Stewart, Jason H Winnike, Susan L McRitchie, Robert F Clark, Wimal W Pathmasiri, Susan J Sumner
To date, no targeted therapies are available to treat triple negative breast cancer (TNBC), while other breast cancer subtypes are responsive to current therapeutic treatment. Metabolomics was conducted to reveal differences in two hormone receptor-negative TNBC cell lines and two hormone receptor-positive Luminal A cell lines. Studies were conducted in the presence and absence of paclitaxel (Taxol). TNBC cell lines had higher levels of amino acids, branched-chain amino acids, nucleotides, and nucleotide sugars and lower levels of proliferation-related metabolites like choline compared with Luminal A cell lines...
September 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27303377/capturing-one-of-the-human-gut-microbiome-s-most-wanted-reconstructing-the-genome-of-a-novel-butyrate-producing-clostridial-scavenger-from-metagenomic-sequence-data
#18
Patricio Jeraldo, Alvaro Hernandez, Henrik B Nielsen, Xianfeng Chen, Bryan A White, Nigel Goldenfeld, Heidi Nelson, David Alhquist, Lisa Boardman, Nicholas Chia
The role of the microbiome in health and disease is attracting great attention, yet we still know little about some of the most prevalent microorganisms inside our bodies. Several years ago, Human Microbiome Project (HMP) researchers generated a list of "most wanted" taxa: bacteria both prevalent among healthy volunteers and distantly related to any sequenced organisms. Unfortunately, the challenge of assembling high-quality genomes from a tangle of metagenomic reads has slowed progress in learning about these uncultured bacteria...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27246112/bcat1-a-key-prognostic-predictor-of-hepatocellular-carcinoma-promotes-cell-proliferation-and-induces-chemoresistance-to-cisplatin
#19
Yi-Hu Zheng, Wei-Jian Hu, Bi-Cheng Chen, Tan-Hooi-Min Grahn, Yan-Rong Zhao, Hai-Li Bao, Ye-Fan Zhu, Qi-Yu Zhang
: BACKGROUND & AIMS: BCAT1 initiates the catabolism of branched-chain amino acids. Here, we investigated the function of BCAT1 and its transcriptional regulatory mechanism in HCC. METHODS: RNA-seq was used to evaluate BCAT1 mRNA levels in HCC and normal matched specimens. After the exogenous expression of BCAT1 in BEL-7404 cells and the suppression of endogenous BCAT1 expression with shRNA in HepG2 cells, the cell proliferation, clone-forming ability, and cell-cycle changes were measured with MTT assay, colony-forming assay, and flow cytometry, respectively...
June 1, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27243100/protein-poly-amino-acid-nanocore-shell-mediated-synthesis-of-branched-gold-nanostructures-for-computed-tomographic-imaging-and-photothermal-therapy-of-cancer
#20
Sisini Sasidharan, Dhirendra Bahadur, Rohit Srivastava
Anisotropic noble metal nanoparticles especially branched gold nanoparticles with a large absorption cross-section and high molar extinction coefficient have promising applications in biomedical field. However, sophisticated and cumbersome methodologies of synthesis along with toxic precursors pose serious concern for its use. Herein, we report the synthesis of branched gold nanostructures from protein (albumin) nanoparticles by a simple reduction method. Albumin nanoparticles were synthesized by a modified desolvation technique with poly-l-arginine (cationic poly amino acid) substituting the conventional toxic cross-linker, glutaraldehyde...
June 29, 2016: ACS Applied Materials & Interfaces
keyword
keyword
92274
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"