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JOURNAL ARTICLE
Meiling Hong, Aiping Jiang, Na Li, Weihao Li, Haitao Shi, Kenneth B Storey, Li Ding
The red-eared slider ( Trachemys scripta elegans ), identified as one of the 100 most invasive species in the world, is a freshwater turtle originally from the eastern United States and northeastern Mexico. Field investigations have shown that T. s. elegans can survive and lay eggs in saline habitats. In order to understand the molecular mechanisms of salinity adaptation, high-throughput RNA-Seq was utilized to identify the changes in gene expression profiles in the liver of T. s. elegans in response to elevated salinity...
2019: PeerJ
#22
MULTICENTER STUDY
Sara Haydar, Florin Grigorescu, Mădălina Vintilă, Yannick Cogne, Corinne Lautier, Yildiz Tutuncu, Jean Frederic Brun, Jean Marie Robine, Michel Pugeat, Christophe Normand, Patrick Poucheret, Monica Livia Gheorghiu, Carmen Georgescu, Corin Badiu, Nicoleta Băculescu, Eric Renard, Dorina Ylli, Stephanie Badiou, Thibault Sutra, Jean Paul Cristol, Jacques Mercier, Ramon Gomis, Josep Maria Macias, Serghey Litvinov, Elza Khusnutdinova, Catalina Poiana, Renato Pasquali, Davide Lauro, Giorgio Sesti, Sabrina Prudente, Vincenzo Trischitta, Agathocles Tsatsoulis, Sonia Abdelhak, Abdelhamid Barakat, Akila Zenati, Agron Ylli, Ilhan Satman, Timo Kanninen, Yves Rinato, Sasa Missoni
Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development of diabetes. To define determinants of insulin resistance (IR) we investigated 73 genes involved in BCAA metabolism or regulation by fine-scale haplotype mapping in two European populations with metabolic syndrome. French and Romanians (n = 465) were genotyped for SNPs (Affymetrix) and enriched by imputation (BEAGLE 4...
2019: PloS One
#23
JOURNAL ARTICLE
Hua Ni, Min Xu, Gui-Lai Zhan, Yu Fan, Hejiang Zhou, Hong-Yan Jiang, Wei-Hong Lu, Liwen Tan, Deng-Feng Zhang, Yong-Gang Yao, Chen Zhang
Depression is one of the most frequent psychiatric symptoms observed in people during the development of Alzheimer's disease (AD). We hypothesized that genetic factors conferring risk of depression might affect AD development. In this study, we screened 31 genes, which were located in 19 risk loci for major depressive disorder (MDD) identified by two recent large genome-wide association studies (GWAS), in AD patients at the genomic and transcriptomic levels. Association analysis of common variants was performed by using summary statistics of the International Genomics of Alzheimer's Project (IGAP), and association analysis of rare variants was conducted by sequencing the entire coding region of the 31 MDD risk genes in 107 Han Chinese patients with early-onset and/or familial AD...
2018: Journal of Alzheimer's Disease: JAD
#24
JOURNAL ARTICLE
Aleksandra Szopa, Ewa Poleszak, Urszula Doboszewska, Mariola Herbet, Katarzyna Świąder, Elżbieta Wyska, Anna Serefko, Aleksandra Wlaź, Agnieszka Korga, Marta Ostrowska, Piotr Juś, Szymon Jedynak, Jarosław Dudka, Piotr Wlaź
RATIONALE: Depressed patients often present increased consumption of caffeine. OBJECTIVES: We aimed to investigate the effects of chronic treatment with caffeine (5 mg/kg, twice daily for 14 days) on the activity of single, ineffective doses of agomelatine (20 mg/kg) or mianserin (10 mg/kg) given on day 15 alone or simultaneously with caffeine. METHODS: We used the forced swim test (FST), tail suspension test (TST), and locomotor activity test in mice and quantitative real-time PCR analysis of the selected genes in the cerebral cortex (Cx)...
August 2018: Psychopharmacology
#25
JOURNAL ARTICLE
Bernard Mulvey, Dionnet L Bhatti, Sandeep Gyawali, Allison M Lake, Skirmantas Kriaucionis, Christopher P Ford, Michael R Bruchas, Nathaniel Heintz, Joseph D Dougherty
Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders. Such disorders are often treated by drugs targeting the CNS norepinephrine system. Despite roles for noradrenergic neurons in behavior and neuropsychiatric disease models, their molecular characterization has lagged. We profiled mouse noradrenergic neurons in vivo, defining over 3,000 high-confidence transcripts expressed therein, including druggable receptors...
May 22, 2018: Cell Reports
#26
JOURNAL ARTICLE
Aleksandra Szopa, Urszula Doboszewska, Mariola Herbet, Sylwia Wośko, Elżbieta Wyska, Katarzyna Świąder, Anna Serefko, Agnieszka Korga, Aleksandra Wlaź, Andrzej Wróbel, Marta Ostrowska, Joanna Terlecka, Adam Kanadys, Ewa Poleszak, Jarosław Dudka, Piotr Wlaź
Recent preclinical and clinical data suggest that low dose of caffeine enhances the effects of common antidepressants. Here we investigated the effects of chronic administration of caffeine (5mg/kg, twice daily for 14days) and its withdrawal on day 15th on the activity of per se ineffective doses of fluoxetine (5mg/kg) and escitalopram (2mg/kg) given on day 15th. We found decreased immobility time in the forced swim and tail suspension tests in mice in which caffeine was administered simultaneously with antidepressants on day 15th following a 14-day caffeine treatment and no alterations in the spontaneous locomotor activity...
December 15, 2017: Toxicology and Applied Pharmacology
#27
JOURNAL ARTICLE
Lijuan Wang, Zhifen Liu, Xiaohua Cao, Jianying Li, Aixia Zhang, Ning Sun, Chunxia Yang, Kerang Zhang
AIMS: The SLC6A15 gene has been identified as a novel candidate gene for major depressive disorder (MDD). However, the mechanism underlying the effects of how the SLC6A15 gene affects functional brain activity of patients with MDD remains unknown. METHODS: In the present study, we investigated the effect of the SLC6A15 gene polymorphism, rs1545843, on resting-state brain function in MDD with the imaging genomic technology and the regional homogeneity (ReHo) method...
September 2017: Genetic Testing and Molecular Biomarkers
#28
JOURNAL ARTICLE
Trillitye Paullin, Chase Powell, Christopher Menzie, Robert Hill, Feng Cheng, Christopher J Martyniuk, Sandy D Westerheide
Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. These poor statistics are related to a lack of early symptoms and inadequate screening techniques. This results in the cancer going undetected until later stages when the tumor has metastasized through a process that requires the epithelial to mesenchymal transition (EMT). In lieu of traditional monolayer cell culture, EMT and cancer progression in general is best characterized through the use of 3D spheroid models...
2017: PloS One
#29
JOURNAL ARTICLE
Ramesh Chandra, T Chase Francis, Hyungwoo Nam, Lace M Riggs, Michel Engeln, Sarah Rudzinskas, Prasad Konkalmatt, Scott J Russo, Gustavo Turecki, Sergio D Iniguez, Mary Kay Lobo
Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] in depression. Given our previous characterization of Slc6a15 as a striatal dopamine receptor 2 (D2)-neuron-enriched gene, we examined the role of Slc6a15 in NAc D2-neurons in mediating susceptibility to stress in male mice. First, we showed that Slc6a15 mRNA was reduced in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behavioral and molecular adaptations that resemble clinical depression...
July 5, 2017: Journal of Neuroscience
#30
JOURNAL ARTICLE
Jinhua Zheng, Xinglong Yang, Quanzhen Zhao, Sijia Tian, Hongyan Huang, Yalan Chen, Yanming Xu
OBJECTIVE: To investigate possible associations of Parkinson's disease (PD) with polymorphism in depression-related genes and in the alpha-synuclein (SNCA) gene. METHODS: A consecutive series of patients with PD were divided into those with depression and those without it. Patients (330) were genotyped at four single-nucleotide polymorphisms (SNPs) in four genes previously associated with depression, as well as four SNPs in the PD-associated SNCA gene. RESULTS: Of 330 patients, 125 (37...
April 15, 2017: Journal of the Neurological Sciences
#31
JOURNAL ARTICLE
Sunyoung Choi, Kyu-Man Han, June Kang, Eunsoo Won, Hun Soo Chang, Woo Suk Tae, Kyu Ri Son, Su-Jin Kim, Min-Soo Lee, Byung-Joo Ham
BACKGROUND: The SLC6A15 gene has been identified as a novel candidate gene for major depressive disorder (MDD). It is presumed to be involved in the pathophysiology of MDD through regulation of glutamate transmission in the brain. However, the involvement of this gene in microstructural changes in white matter (WM) tracts remains unclear. We aimed to investigate the influence of a polymorphism of this gene (rs1545853) on the structural integrity of WM tracts in the cortico-limbic network...
2016: PloS One
#32
JOURNAL ARTICLE
Gaia De Sanctis, Michela Spinelli, Marco Vanoni, Elena Sacco
BACKGROUND: Cancer cells have an increased demand for amino acids and require transport even of non-essential amino acids to support their increased proliferation rate. Besides their major role as protein synthesis precursors, the two proteinogenic sulfur-containing amino acids, methionine and cysteine, play specific biological functions. In humans, methionine is essential for cell growth and development and may act as a precursor for cysteine synthesis. Cysteine is a precursor for the biosynthesis of glutathione, the major scavenger for reactive oxygen species...
2016: PloS One
#33
JOURNAL ARTICLE
S Santarelli, K V Wagner, C Labermaier, A Uribe, C Dournes, G Balsevich, J Hartmann, M Masana, F Holsboer, A Chen, M B Müller, M V Schmidt
Major depression is a multifactorial disease, involving both environmental and genetic risk factors. Recently, SLC6A15 - a neutral amino acid transporter mainly expressed in neurons - was proposed as a new candidate gene for major depression and stress vulnerability. Risk allele carriers for a single nucleotide polymorphism (SNP) in a SLC6A15 regulatory region display altered hippocampal volume, glutamate levels, and hypothalamus-pituitary-adrenal axis activity, all markers associated with major depression...
2016: Stress: the International Journal on the Biology of Stress
#34
JOURNAL ARTICLE
Ingo Marenholz, Jorge Esparza-Gordillo, Franz Rüschendorf, Anja Bauerfeind, David P Strachan, Ben D Spycher, Hansjörg Baurecht, Patricia Margaritte-Jeannin, Annika Sääf, Marjan Kerkhof, Markus Ege, Svetlana Baltic, Melanie C Matheson, Jin Li, Sven Michel, Wei Q Ang, Wendy McArdle, Andreas Arnold, Georg Homuth, Florence Demenais, Emmanuelle Bouzigon, Cilla Söderhäll, Göran Pershagen, Johan C de Jongste, Dirkje S Postma, Charlotte Braun-Fahrländer, Elisabeth Horak, Ludmila M Ogorodova, Valery P Puzyrev, Elena Yu Bragina, Thomas J Hudson, Charles Morin, David L Duffy, Guy B Marks, Colin F Robertson, Grant W Montgomery, Bill Musk, Philip J Thompson, Nicholas G Martin, Alan James, Patrick Sleiman, Elina Toskala, Elke Rodriguez, Regina Fölster-Holst, Andre Franke, Wolfgang Lieb, Christian Gieger, Andrea Heinzmann, Ernst Rietschel, Thomas Keil, Sven Cichon, Markus M Nöthen, Craig E Pennell, Peter D Sly, Carsten O Schmidt, Anja Matanovic, Valentin Schneider, Matthias Heinig, Norbert Hübner, Patrick G Holt, Susanne Lau, Michael Kabesch, Stefan Weidinger, Hakon Hakonarson, Manuel A R Ferreira, Catherine Laprise, Maxim B Freidin, Jon Genuneit, Gerard H Koppelman, Erik Melén, Marie-Hélène Dizier, A John Henderson, Young Ae Lee
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12...
November 6, 2015: Nature Communications
#35
JOURNAL ARTICLE
Sara Santarelli, Christian Namendorf, Elmira Anderzhanova, Tamara Gerlach, Benedikt Bedenk, Sebastian Kaltwasser, Klaus Wagner, Christiana Labermaier, Judith Reichel, Jana Drgonova, Michael Czisch, Manfred Uhr, Mathias V Schmidt
Although mental disorders as major depression are highly prevalent worldwide their underlying causes remain elusive. Despite the high heritability of depression and a clear genetic contribution to the disease, the identification of genetic risk factors for depression has been very difficult. The first published candidate to reach genome-wide significance in depression was SLC6A15, a neuronal amino acid transporter. With a reported 1,42 fold increased risk of suffering from depression associated with a single nucleotide polymorphism (SNP) in a regulatory region of SLC6A15, the polymorphism was also found to affect hippocampal morphology, integrity, and hippocampus-dependent memory...
September 2015: Journal of Psychiatric Research
#36
JOURNAL ARTICLE
Serena Cuboni, Christian Devigny, Bastiaan Hoogeland, Andrea Strasser, Sebastian Pomplun, Barbara Hauger, Georg Höfner, Klaus T Wanner, Matthias Eder, Armin Buschauer, Florian Holsboer, Felix Hausch
B(0)AT2, encoded by the SLC6A15 gene, is a transporter for neutral amino acids that has recently been implicated in mood and metabolic disorders. It is predominantly expressed in the brain, but little is otherwise known about its function. To identify inhibitors for this transporter, we screened a library of 3133 different bioactive compounds. Loratadine, a clinically used histamine H1 receptor antagonist, was identified as a selective inhibitor of B(0)AT2 with an IC50 of 4 μM while being less active or inactive against several other members of the SLC6 family...
November 26, 2014: Journal of Medicinal Chemistry
#37
JOURNAL ARTICLE
Radosław Januchowski, Piotr Zawierucha, Marcin Ruciński, Małgorzata Andrzejewska, Karolina Wojtowicz, Michał Nowicki, Maciej Zabel
Ovarian cancer is characterized by the higher mortality among gynecological cancers. In results of MDR development during chemotherapy cancer cells become resistant to further treatment. Microarray techniques can provide information about MDR development at gene expression level. ABC and SLC transporters are most important proteins responsible for this phenomenon. In this study changes of ABC and SLC genes expression pattern in drugs resistant sublines of the A2780 ovarian cancer cell line were demonstrated...
May 2014: Biomedicine & Pharmacotherapy
#38
JOURNAL ARTICLE
Jingzi Wang, Xiaobei Mao, Youwei Zhang, Lijun Xue, Xiaobei Liu, Jian Geng, Lili Ren, Hongju Yu, Longbang Chen, Xiaoyuan Chu
OBJECTIVE: To study the methylation changes in promoter CpG islands induced by low-dose X-ray radiation (LDR). METHODS: Twenty male BALB/c mice were randomly divided into control and fractionated radiation group exposed to 6 MV X-ray for 10 days (0.05 Gy/day). All the mice were sacrificed 2 h after the last radiation on day 10, and blood samples were collected for detecting DNA methylation changes using Roche-NimbleGen mouse DNA methylation 3×720K Promoter Plus CpG Island Array...
February 2014: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
#39
JOURNAL ARTICLE
Susan M Mitchell, Jason P Ross, Horace R Drew, Thu Ho, Glenn S Brown, Neil F W Saunders, Konsta R Duesing, Michael J Buckley, Rob Dunne, Iain Beetson, Keith N Rand, Aidan McEvoy, Melissa L Thomas, Rohan T Baker, David A Wattchow, Graeme P Young, Trevor J Lockett, Susanne K Pedersen, Lawrence C Lapointe, Peter L Molloy
BACKGROUND: The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity and specificity of current cancer detection tests...
2014: BMC Cancer
#40
JOURNAL ARTICLE
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes.
Jana Drgonova, Josefin A Jacobsson, Joan C Han, Jack A Yanovski, Robert Fredriksson, Claude Marcus, Helgi B Schiöth, George R Uhl
Brain pathways, including those in hypothalamus and nucleus of the solitary tract, influence food intake, nutrient preferences, metabolism and development of obesity in ways that often differ between males and females. Branched chain amino acids, including leucine, can suppress food intake, alter metabolism and change vulnerability to obesity. The SLC6A15 (v7-3) gene encodes a sodium-dependent transporter of leucine and other branched chain amino acids that is expressed by neurons in hypothalamus and nucleus of the solitary tract...
2013: PloS One
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