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Devra D Huey, Brad Bolon, Krista M D La Perle, Priya Kannian, Steven Jacobson, Lee Ratner, Patrick L Green, Stefan Niewiesk
Chronic infection with human T-cell leukemia virus type 1 (HTLV1) can lead to adult T-cell leukemia (ATL). In contrast, infection with HTLV2 does not lead to leukemia, potentially because of distinct virus-host interactions and an active immune response that controls virus replication and, therefore, leukemia development. We created a humanized mouse model by injecting human umbilical-cord stem cells into the livers of immunodeficient neonatal NSG mice, resulting in the development of human lymphocytes that cannot mount an adaptive immune response...
February 1, 2018: Comparative Medicine
Aline Garcia Kozlowski, Márcia Alves Dias de Matos, Megmar Aparecida Dos Santos Carneiro, Carmen Luci Rodrigues Lopes, Sheila Araújo Teles, Carolina Paulo Vicente, Regina Maria Bringel Martins
Human T-cell lymphotropic virus (HTLV) may affect the clinical course of human immunodeficiency virus 1 (HIV1). Both infections are common in endemic areas because these viruses share similar routes of transmission. The aim of this study was to estimate the seroprevalence of HTLV1/2 in a population of HIV1-infected patients in the state of Goiás, Midwestern Brazil. Of the 505 studied patients, four (0.79%) were positive for anti-HTLV1/2 by enzyme-linked immunosorbent assay (ELISA), with HTLV1 infection confirmed by line immunoassay (LIA) and polymerase chain reaction (PCR) in all of the ELISA-positive samples...
November 3, 2016: Revista do Instituto de Medicina Tropical de São Paulo
Ivan V Litvinov, Anna Shtreis, Kenneth Kobayashi, Steven Glassman, Matthew Tsang, Anders Woetmann, Denis Sasseville, Niels Ødum, Madeleine Duvic
Most skin malignancies are caused by external and often preventable environmental agents. Multiple reports demonstrated that cutaneous T-cell lymphomas (CTCL) can occur in married couples and cluster in families. Furthermore, recent studies document geographic clustering of this malignancy in Texas as well as in other areas of the United States. Multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide diuretics, Staphylococcus aureus, dermatophytes, Mycobacterium leprae, Chlamydia pneumoniae, human T-Cell lymphotropic virus type 1 (HTLV1), Epstein-Barr virus (EBV), and herpes simplex virus (HSV)...
July 2016: Oncoimmunology
Rahul Dimber, Qi Guo, Courtney Bishop, Adine Adonis, Aisling Buckley, Agnes Kocsis, David Owen, Nicola Kalk, Rexford Newbould, Roger N Gunn, Eugenii A Rabiner, Graham P Taylor
HTLV-1-associated myelopathy (HAM; HTLV-1 is human T-lymphotropic virus type 1) is a chronic debilitating neuroinflammatory disease with a predilection for the thoracic cord. Tissue damage is attributed to the cellular immune response to HTLV-1-infected lymphocytes. The brains of HTLV-1-infected patients, with and without HAM but no clinical evidence of brain involvement, were examined using a specific 18-kDa translocator protein ligand, 11 C-PBR28, and T1-weighted and diffusion-weighted MRI. METHODS: Five subjects with HAM and 2 HTLV-1 asymptomatic carriers were studied...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Reza Shafiei, Mohsen Najjari, Ali Kargar Kheirabad, Golamreza Hatam
Cystoisospora belli, formerly Isospora belli, as an opportunistic infection agent, is seen in immunocompromised patients like HTLV-1. We describe here cystoisosporiasis in an HTLV1 Iranian female in Mashhad, northwestern Iran in 2012 who presented with a debilitating diarrheal illness and great weight loss. C. belli was detected in her stool by modified acid-fast staining and then by molecular detection. Serologic testing was negative for HIV but she showed positivity for HTLV-1 infection. Treatment with TMP/SMX led to improvement of her diarrhea but she died after one year due to malabsorption syndrome...
January 2016: Iranian Journal of Parasitology
Lorena A Pinto, Cássio S Meira, Cristiane F Villarreal, Marcos A Vannier-Santos, Claudia V C de Souza, Ivone M Ribeiro, Therezinha C B Tomassini, Bernardo Galvão-Castro, Milena B P Soares, Maria F R Grassi
Human T-lymphotropic virus type 1 (HTLV-1) induces a strong activation of the immune system, especially in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. The present study aimed to investigate the effects of physalin F on peripheral blood mononuclear cells (PBMC) of HAM/TSP subjects. A concentration-dependent inhibition of spontaneous proliferation of PBMC from HAM/TSP subjects was observed in the presence of physalin F, as evaluated by (3)H-thymidine uptake...
April 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
E L Murphy
Many countries currently perform antibody screening for HTLV-1 infection in blood donors, and this intervention is likely cost-effective in preventing HTLV-1 related diseases in high prevalence countries. However, a number of high-income countries with low prevalence of HTLV-1 infection also perform universal HTLV-1 screening and debate has arisen regarding the cost-effectiveness of these strategies. Filter-based leukoreduction is likely to substantially reduce HTLV-1 transmission by removing infected lymphocytes, but actual laboratory data on its efficacy is currently lacking...
February 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Masood Ziaee, Mohammad Hassan Namaei, Ghodseh Azarkar
BACKGROUND AND OBJECTIVE: Blood-borne infections, such as the HIV virus and hepatitis B and C, are major problems in patients receiving blood products. Here we examined the prevalence of HTLV-1, HCV, HBV, and HIV in hemophilic patients. METHODS: A cross-sectional study on 108 hemophilic patients (101 males and 7 females) involved detection of HBV, HCV, HIV and HTLV-1 infections using immunoassays for HBsAg, hepatitis B core antibodies (anti-HBc), hepatitis C antibodies (anti-HCV), HIV antibodies (anti-HIV) and Anti-HTLV-1...
September 2015: Pakistan Journal of Medical Sciences Quarterly
Akira Satou, Naoko Asano, Seiichi Kato, Hiroo Katsuya, Kenji Ishitsuka, Ahmed A Elsayed, Shigeo Nakamura
AIMS: Forkhead box protein 3-positive (FoxP3(+) ) T cell lymphoma, in the absence of human T cell lymphotrophic virus type 1 (HTLV-1) infection, is rare and its clinicopathological characteristics still remain unclear. The aim of this study was to elucidate its characteristics. METHODS AND RESULTS: We describe here 11 cases of peripheral T cell lymphoma not otherwise specified (PTCL-NOS) and two cases of mycosis fingoides (MF) which were positive for FoxP3. The median age of the 11 PTCL-NOS cases was 65 years (range: 48-80 years), and all the patients were male...
June 2016: Histopathology
Alidou Traore, Jean Cyr Yombi, Karim Tribak, Olivier Cornu
BACKGROUND: To evaluate the incidence and the risk of transmitting a virus through a bone allograft from a living donor. MATERIAL AND METHODS: A total 7032 femoral heads have been collected from 24 Belgian institutions. The tissue along with the screening blood tests were systematically sent to the bank. Serological screening included: for HIV, a HIV1-2 antibody test; for HBV, a HBS antigen and HBS and Hbcore antibodies; for HCV, a HCV antibody test. Syphilis was also screened with a non-specific and a specific assays...
September 2013: Journal of Clinical Orthopaedics and Trauma
A Moghadam-Ahmadi, R Boostani, Z Tafakhori, A Sharifi-Razavi
INTRODUCTION: Human T-lymphotropic virus type 1 (HTLV-1), was the first human retrovirus to be discovered in 1980. The majority of HTLV-1 infected individuals (95%) will remain asymptomatic for their lifelong; whereas 5% of these patients will be symptomatic, mainly hematologic and neurologic. CASE REPORT: We present four patients with HTLV-1 infection (from Mashhad and Neyshabur cities in Khorasan province in the northeast of Iran as an endemic region) who were referred with MS-like clinical picture associated with some hyperintense lesions in brain MRI...
November 2014: Multiple Sclerosis and related Disorders
Etienne Ghrenassia, Nihal Martis, Julien Boyer, Fanny Burel-Vandenbos, Arsène Mekinian, Paul Coppo
The Diffuse Infiltrative Lymphocytosis Syndrome (DILS) is a rare multisystemic syndrome described in HIV-infected patients. It is characterised by CD8(+) T-cell lymphocytosis associated with a CD8(+) T-cell infiltration of multiple organs. DILS is usually seen in uncontrolled or untreated HIV infection but can also manifest itself independently of CD4(+) T-cell counts. The syndrome may present as a Sjögren-like disease that generally associates sicca signs with bilateral parotiditis, lymphadenopathy, and extraglandular organ involvement...
May 2015: Journal of Autoimmunity
Abigail Morales-Sánchez, Ezequiel M Fuentes-Pananá
The first human tumor virus was discovered in the middle of the last century by Anthony Epstein, Bert Achong and Yvonne Barr in African pediatric patients with Burkitt's lymphoma. To date, seven viruses -EBV, KSHV, high-risk HPV, MCPV, HBV, HCV and HTLV1- have been consistently linked to different types of human cancer, and infections are estimated to account for up to 20% of all cancer cases worldwide. Viral oncogenic mechanisms generally include: generation of genomic instability, increase in the rate of cell proliferation, resistance to apoptosis, alterations in DNA repair mechanisms and cell polarity changes, which often coexist with evasion mechanisms of the antiviral immune response...
October 23, 2014: Viruses
Hamidreza Safabakhsh, Mehrdad Jalalian, Gharib Karimi
INTRODUCTION: Human T-cell lymphotropic virus (HTLV-I) is associated with adult T cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The major routes of HTLV-I transmission are mother-to-child, sexual contact, and blood transfusion. Mashhad is one of the main endemic areas in the world for HTLV-I, and minimizing the risk of HTLV-I transmission through blood transfusion is one of the main duties of the Blood Transfusion Center in Mashhad...
September 2014: Global Journal of Health Science
Kenneth S Charles, Niall Leelah, Desiree C Murray
The ophthalmic presentation of relapse in a patient with human T-lymphotropic virus type 1 (HTLV1) associated adult T-cell lymphoma leukaemia is described. Epidemiology, clinical features and therapeutic options are briefly reviewed. Antenatal screening and inclusion of HTLV1 in the differential diagnosis of inflammatory and neuromuscular eye conditions should be considered in endemic regions.
April 2014: Tropical Doctor
JoAnn L Yee, Nestor A Montiel, Amir Ardeshir, Amir Ardeshr, Nicholas W Lerche
Simian T-cell lymphotropic viruses (STLV), the nonhuman primate counterparts of human T-cell lymphotropic viruses (HTLV), are endemic in many populations of African and Asian monkeys and apes. Although an etiologic link between STLV1 infection and lymphoproliferative disorders such as malignant lymphomas has been suggested in some nonhuman primate species, most STLV infections are inapparent, and infected animals remain clinically healthy. The retroviral transactivator, tax, is well known to increase transcription of viral and cellular genes, resulting in altered cytokine profiles...
2013: Comparative Medicine
Abigail Morales-Sánchez, Roberto Bernáldez-Ríos, Francisco Javier Alvarez-Rodríguez, Vilma Carolina Bekker-Méndez, Arturo Fajardo-Gutiérrez, José de Diego Flores-Chapa, Janet Flores-Lujano, Elva Jiménez-Hernández, José Gabriel Peñaloza-González, María Del Carmen Rodríguez-Zepeda, José Refugio Torres-Nava, Martha Margarita Velázquez-Aviña, Raquel Amador-Sánchez, Martha Alvarado-Ibarra, Nancy Reyes-Zepeda, Rosa Martha Espinosa-Elizondo, Ezequiel M Fuentes-Pananá, Juan Manuel Mejía-Aranguré
BACKGROUND: In Mexico City, the incidence of childhood acute lymphoblastic leukemia (ALL) is one of the highest in the world; epidemiologic evidence suggests that infectious agents could be involved in the genesis of this disease. Early transmitted oncogenic retroviruses infecting lymphocytes are important candidates. METHODS: PCR-based assays were used to screen viral genomic sequences of human T-cell lymphotrophic virus, type 1 (HTLV1) and mouse mammary tumor virus (MMTV)-like virus (MMTV-LV) in leukemic cells from 67 pediatric patients with ALL...
November 2013: Cancer Epidemiology, Biomarkers & Prevention
Elise Gouhier, Emilie Gaubert-Maréchal, Philippe Abboud, Pierre Couppié, Mathieu Nacher
French Guiana, the French territory most affected by human immunodeficiency virus (HIV) (1.3% of pregnant women), is also endemic for human T lymphotropic virus 1 (HTLV1). The objective of this study was to determine if the HTLV1/HIV coinfected patients had particular characteristics. All HIV-infected patients having a computerized medical file containing an HTLV1 serology were included: there were 1,333 HIV monoinfections and 76 HTLV1/VIH coinfections. The prevalence of HTLV1/HIV coinfections was 5.39%. Women (odds ratio [OR] = 1...
September 2013: American Journal of Tropical Medicine and Hygiene
Paul Kirk, Aviva Witkover, Charles R M Bangham, Sylvia Richardson, Alexandra M Lewin, Michael P H Stumpf
Recent studies have highlighted the importance of assessing the robustness of putative biomarkers identified from experimental data. This has given rise to the concept of stable biomarkers, which are ones that are consistently identified regardless of small perturbations to the data. Since stability is not by itself a useful objective, we present a number of strategies that combine assessments of stability and predictive performance in order to identify biomarkers that are both robust and diagnostically useful...
December 2013: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
Javad Ghaffari, Mahbobeh Ebrahimi, Atieh Makhlough, Hamid Mohammadjafari, Zeinab Nazari
Human T-cell lymphotropic virus 1 (HTLV1) is a lymphotropic virus which can be transmitted through unprotected sexual activity, breast feeding, and blood transfusion. Although most of HTLV1-infected individuals remain asymptomatic carriers, 1% to 5% and 3% to 5% develop adult T-cell leukemia and HTLV1-associated myelopathy/tropical spastic paraparesis, respectively. The aim of this study was to determine the prevalence of HTLV1 infection in hemodialysis patients in Sari and Ghaemshahr. This cross-sectional study was conducted on160 patients using random samples selection, and included 80 men and 80 women (mean age, 59...
May 2013: Iranian Journal of Kidney Diseases
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