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https://www.readbyqxmd.com/read/29315502/a-genome-wide-association-study-identifies-a-candidate-gene-associated-with-atazanavir-exposure-measured-in-hair
#1
Bani Tamraz, Yong Huang, Audrey L French, Seble Kassaye, Kathryn Anastos, Marek J Nowicki, Stephen Gange, Deborah R Gustafson, Peter Bacchetti, Ruth M Greenblatt, Pirro G Hysi, Bradley E Aouizerat
Hair provides a direct measure of long-term exposure of atazanavir (ATV). We report the results of the first genome-wide association study (GWAS) of ATV exposure measured in hair in an observational cohort representative of U.S. women living with HIV; the Women's Interagency HIV Study. Approximately 14.1 million SNPs were analyzed in linear regression-based GWAS, with replication, adjusted for non-genetic predictors collected under conditions of actual use of ATV in 398 participants. Lastly, the PharmGKB database was used to identify pharmacogene associations with ATV exposure...
January 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29301538/hair-product-use-age-at-menarche-and-mammographic-breast-density-in-multiethnic-urban-women
#2
Jasmine A McDonald, Parisa Tehranifar, Julie D Flom, Mary Beth Terry, Tamarra James-Todd
BACKGROUND: Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast density. METHODS: In two urban female cohorts (N = 248): 1) the New York site of the National Collaborative Perinatal Project and 2) the New York City Multiethnic Breast Cancer Project, we measured childhood and adult use of hair oils, lotions, leave-in conditioners, root stimulators, perms/relaxers, and hair dyes using the same validated questionnaire...
January 4, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29273420/allergens-of-permanent-hair-dyes-induces-epidermal-damage-skin-barrier-loss-and-il-1-%C3%AE-increase-in-epidermal-in-vitro-model
#3
Thalita Boldrin Zanoni, Tatiana Nascimento Pedrosa, Carolina Motter Catarino, Sander W Spiekstra, Danielle Palma de Oliveira, Gertjan Den Hartog, Aalt Bast, Geja Hagemann, Susan Gibbs, Silvia Berlanga de Moraes Barros, Silvya Stuchi Maria-Engler
Allergic and irritant skin reactions caused by topical exposure to permanent hair dyes are a common problem. For regulatory and ethnical purposes, it is required to perform chemical safety assessment following the replacement, reduction, and refinement of animal testing (3Rs). Permanent hair dyes are formed by a mixture of ingredients that vary from low to extreme skin sensitizing potency and that inter-react to form unknown by-products. Because of the complex reaction, this cytotoxic mechanism has not yet been elucidated and is the subject of this study...
December 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29241771/alopecia-areata-disease-characteristics-clinical-evaluation-and-new-perspectives-on-pathogenesis
#4
REVIEW
Lauren C Strazzulla, Eddy Hsi Chun Wang, Lorena Avila, Kristen Lo Sicco, Nooshin Brinster, Angela M Christiano, Jerry Shapiro
Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant variations in the clinical presentation of AA have been observed, ranging from small, well-circumscribed patches of hair loss to a complete absence of body and scalp hair. Patients affected by AA encompass all age groups, sexes, and ethnicities, and may experience frustration with the unpredictable nature of their disease for which there is currently no definitive treatment. The cause of AA remains incompletely understood, though it is believed to result-at least in part-from a loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle destruction, and the upregulation of inflammatory pathways...
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29240822/acne-keloidalis-nuchae-in-asian-a-single-institutional-experience
#5
Kiyong Na, Sang Ho Oh, Sang Kyum Kim
Acne keloidalis nuchae, a type of folliculitis involving the back of the neck, is common in black men, although rare cases have been reported in patients of other ethnicities. We analyzed the clinicopathological features of acne keloidalis nuchae in 17 Asians. Patients' age at the time of presentation ranged from 20 to 69 years. Most patients experienced the disease over 2 years (range, 3 months-20 years); follow-up data were available for 11 (65%) patients (range, 2-95 months). Nine (53%) patients had comorbidities, but none had a history of other skin disease or a family history of acne keloidalis nuchae...
2017: PloS One
https://www.readbyqxmd.com/read/29230660/dietary-intake-of-soy-and-cruciferous-vegetables-and-treatment-related-symptoms-in-chinese-american-and-non-hispanic-white-breast-cancer-survivors
#6
Sarah J O Nomura, Yi-Ting Hwang, Scarlett Lin Gomez, Teresa T Fung, Shu-Lan Yeh, Chiranjeev Dash, Laura Allen, Serena Philips, Leena Hilakivi-Clarke, Yun-Ling Zheng, Judy Huei-Yu Wang
PURPOSE: This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. METHODS: This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0-III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29226590/dheas-patterning-across-childhood-in-three-sub-saharan-populations-associations-with-age-sex-ethnicity-and-cortisol
#7
Courtney Helfrecht, Edward H Hagen, David DeAvila, Robin M Bernstein, Samuel J Dira, Courtney L Meehan
OBJECTIVES: Hormones have many roles in human ontogeny, including the timing of life history 'switch points' across development. Limited hormonal data exist from non-Western children, leaving a significant gap in our understanding of the diversity of life history patterning. This cross-sectional study examines dehydroepiandrosterone sulfate (DHEAS) production in relation to age, sex, ethnicity, and cortisol concentrations, as well as average age of adrenarche, among Aka and Ngandu children of the Central African Republic and Sidama children of Ethiopia...
December 11, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29210195/hair-nicotine-at-15-months-old-tobacco-exposure-and-wheeze-or-asthma-from-15-months-to-6-years-old
#8
Philip K Pattemore, Karen M Silvers, Chris M Frampton, Kristin Wickens, Tristram Ingham, David Fishwick, Julian Crane, G Ian Town, Michael J Epton
OBJECTIVE: To investigate the relationship between hair nicotine levels at 15 months of age and prior parent-reported smoking exposure, and the risk of wheezing and current asthma from 15 months to 6 years of age. STUDY DESIGN: We measured hair nicotine levels at 15 months of age in 376 of 535 infants enrolled in a prospective birth cohort in Christchurch, New Zealand. We obtained detailed information from parents about smoking exposure during pregnancy and in the home at 3 and 15 months of age...
December 6, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29186301/toenail-manganese-a-sensitive-and-specific-biomarker-of-exposure-to-manganese-in-career-welders
#9
Eric J Ward, David A Edmondson, Mahmoud M Nour, Sandy Snyder, Frank S Rosenthal, Ulrike Dydak
Manganese (Mn) is an essential trace metal. It is also a component of welding fume. Chronic inhalation of manganese from welding fume has been associated with decreased neurological function. Currently, there is not a universally recognized biomarker for Mn exposure; however, hair and toenails have shown promise. In a cohort of 45 male welders and 35 age-matched factory control subjects, we assessed the sensitivity and specificity of toenail Mn to distinguish occupationally exposed subjects from unexposed controls...
November 25, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29177146/patchy-frontal-fibrosing-alopecia-description-of-an-incomplete-clinical-presentation
#10
Leticia Arsie Contin, Yana Lya de Almeida Ledá, Kédima Caldeira Nassif, Maria Victoria Suárez Restrepo
We describe 6 incomplete cases of frontal fibrosing alopecia (FFA). All patients were postmenopausal women. Their average age was 60 years; 2 of the women were Caucasian, and the remaining 4 women were of a mixed ethnicity. The disease duration ranged from 3 to 17 years. The patients' lesions presented as irregular alopecic plaques in the frontal and/or temporal regions, with few signs of perifollicular inflammation, slow progression, and progressive loss of the vellus hair in the frontal area. Loss of the eyebrows, facial hyperpigmentation, and loss of the body hair were observed in 3 patients, 1 patient, and 2 patients, respectively...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29171081/in-vitro-determination-of-mexican-mestizo-hair-shaft-diameter-using-optical-coherence-tomography
#11
Maria Abril Martinez-Velasco, Marina Perper, Austin J Maddy, Jessica Cervantes, Ariel E Eber, Sebastian H Verne, Norma Elizabeth Vazquez-Herrera, Keyvan Nouri, Antonella Tosti
BACKGROUND: Mexican mestizo population has a pluriethnic mixture of Amerindian, European and African ancestry, predominant in most Latin American countries. Until now, there are no reports about hair characteristics in this population, necessary to define normal values, for hair diseases evaluation and comparison among other ethnic groups. METHODS: The VivoSight® swept-source multibeam optical coherence tomography system was used to evaluate hair diameter and shape in 30 females...
November 23, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/29145581/prospective-epidemiological-research-studies-in-iran-the-persian-cohort-rationale-objectives-and-design
#12
Hossein Poustchi, Sareh Eghtesad, Farin Kamangar, Arash Etemadi, Abbas-Ali Keshtkar, Azita Hekmatdoost, Zahra Mohammadi, Zahra Mahmoudi, Amaneh Shayanrad, Farzin Roozafzai, Mahdi Sheikh, Alireza Jalaeikhoo, Mohammad Hossein Somi, Fariborz Mansour-Ghanaei, Farid Najafi, Ehsan Bahramali, Amirhoushang Mehrparvar, Alireza Ansari-Moghaddam, Ahmad Ali Enayati, Ali Esmaeili Nadimi, Abbas Rezaianzadeh, Nader Saki, Fatemeh Alipour, Roya Kelishadi, Afarin Rahimi-Movaghar, Nayyereh Aminisani, Paolo Boffetta, Reza Malekzadeh
Non-communicable diseases (NCDs) account for 76% of deaths in Iran and this number is on the rise, parallel to global rates. Many risk factors associated with NCDs are preventable; however it is first necessary to conduct observational studies to identify relevant risk factors, and the most appropriate approach to control them. Iran is a multi-ethnic country, therefore the Ministry of Health and Medical Education sought to launch a nationwide cohort study-the Prospective Epidemiological Research Studies in IrAN (PERSIAN)-in order to identify the most prevalent NCDs among Iranian ethnicities, and to investigate effective methods of prevention...
November 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29141068/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach
#13
Neil S Sadick, Valerie D Callender, Leon H Kircik, Sophia Kogan
<p>Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29108540/cosmetic-concerns-among-ethnic-men
#14
REVIEW
Michelle Henry
Men of all races are currently more open to requesting and undergoing treatments for a plethora of cosmetic concerns. Among the most common goals are procedures that combat the signs of aging, rejuvenate the skin, even out the color tone, address textural issues such as acne scarring, and improve hair disorders. Given the differences in cultural ideals and anatomic/physiologic differences in ethnic skin, it is important for physicians to be aware and sensitive to the nuances required when providing consultation and treating non-Caucasian men...
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29105165/a-somewhat-unexpected-result-from-the-deconvolution-of-dsc-curves-for-human-hair-there-is-no-apparent-relation-between-cortical-cell-fractions-and-hair-curliness
#15
Franz J Wortmann, Gabriele Wortmann
A deconvolution process has been developed for curves obtained by Differential Scanning Calorimetry in water for Merino wool and the main ethnic hair types. This enables estimation of the fractions of ortho- and para-type cell groups. The results also indicate that hair may contain a further, low-sulphur sub-group of ortho-type cells. The sizes of the major cell fractions are in line with expectations from microscopical investigations. The fractions are comparable for hair types and no consistent association between cell type fractions and hair curvature is observed...
November 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29020129/maternal-pre-pregnancy-bmi-gestational-weight-gain-and-daughter-s-age-at-menarche-the-avon-longitudinal-study-of-parents-and-children
#16
Rebecca B Lawn, Debbie A Lawlor, Abigail Fraser
Earlier puberty and menarcheal age are associated with adverse health outcomes. Reported associations of maternal adiposity with daughters' menarcheal age are inconsistent. We examined associations between maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG), and daughters' age at menarche (n = 3,935), pubarche (Tanner stage 2 for pubic hair) and thelarche (Tanner stage 2 for breast development) (n = 2,942) in the Avon Longitudinal Study of Parents and Children, a UK prospective pregnancy cohort (baseline 1991-1992)...
September 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28988001/prevalence-of-and-risk-factors-for-non-suicidal-self-injury-in-rural-china-results-from-a-nationwide-survey-in-china
#17
Jie Tang, Guowei Li, Baoxin Chen, Zhijie Huang, Yanmei Zhang, Hongjuan Chang, Chunxia Wu, Xiaoguang Ma, Jiaji Wang, Yizhen Yu
BACKGROUND: Non-suicidal self-injury (NSSI) is a highly prevalent and serious public health problem among adolescents worldwide. However, to date there were no studies assessing the prevalence of NSSI defined by suggested DSM-5 criteria among Chinese adolescents. We aimed to conduct a nationwide survey to explore the prevalence of and risk factors for NSSI among school-based adolescents in rural China. METHODS: A total sample of 15,623 adolescents in rural China were enrolled by using a multistage sampling method...
September 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28983193/maternal-lifetime-trauma-exposure-prenatal-cortisol-and-infant-negative-affectivity
#18
Michelle Bosquet Enlow, Katrina L Devick, Kelly J Brunst, Lianna R Lipton, Brent A Coull, Rosalind J Wright
Little research has examined the impact of maternal lifetime trauma exposure on infant temperament. We examined associations between maternal trauma history and infant negative affectivity and modification by prenatal cortisol exposure in a sociodemographically diverse sample of mother-infant dyads. During pregnancy, mothers completed measures of lifetime trauma exposure and current stressors. Third-trimester cortisol output was assessed from maternal hair. When infants were 6 months old, mothers completed the Infant Behavior Questionnaire-Revised...
July 2017: Infancy: the Official Journal of the International Society on Infant Studies
https://www.readbyqxmd.com/read/28939588/childhood-socioeconomic-position-and-pubertal-onset-in-a-cohort-of-multiethnic-girls-implications-for-breast-cancer
#19
Robert A Hiatt, Susan L Stewart, Kristin S Hoeft, Lawrence H Kushi, Gayle C Windham, Frank M Biro, Susan M Pinney, Mary S Wolff, Susan L Teitelbaum, Dejana Braithwaite
BACKGROUND: Higher socioeconomic position (SEP) has been associated with increased risk of breast cancer. Its relationship with earlier age of pubertal onset, a risk factor for breast cancer, is less clear. METHODS: We studied the relationship of SEP to pubertal onset in multiethnic cohort of 1237 girls aged 6-8 years at baseline. Girls in three U.S. cities were followed for 5-8 years with annual clinical examinations from 2004 to 2012. SEP measures were examined for associations with pubertal onset, assessed by breast budding (thelarche) and pubic hair development (adrenarche)...
September 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28878338/the-clinical-characteristics-of-asian-patients-with-classical-type-hutchinson-gilford-progeria-syndrome
#20
Nanae Sato-Kawano, Minoru Takemoto, Emiko Okabe, Koutaro Yokote, Muneaki Matsuo, Rika Kosaki, Kenji Ihara
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that shows a characteristic progeria phenotype. We conducted a questionnaire survey of 1173 tertiary hospitals in Japan and reviewed the academic reports, to identify the characteristics of Asian patients with classical HGPS. As a result, four Japanese patients were identified; this was estimated to account for approximately two-third of the prevalence in Japan. Three Asian patients who had definitively been diagnosed with classical HGPS were identified in the literature; in total, the clinical characteristics of seven patients were evaluated...
September 7, 2017: Journal of Human Genetics
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