keyword
MENU ▼
Read by QxMD icon Read
search

boberg

keyword
https://www.readbyqxmd.com/read/28526456/combined-exposure-to-low-doses-of-pesticides-causes-decreased-birth-weights-in-rats
#1
Ulla Hass, Sofie Christiansen, Marta Axelstad, Martin Scholze, Julie Boberg
Decreased birth weight is a common effect of many pesticides in reproductive toxicity studies, but there are no empirical data on how pesticides act in combination on this endpoint. We hypothesized that a mixture of six pesticides (cyromazine, MCPB, pirimicarb, quinoclamine, thiram, and ziram) would decrease birth weight, and that these mixture effects could be predicted by the Dose Addition model. Data for the predictions were obtained from the Draft Assessment Reports of the individual pesticides. A mixture of equi-effective doses of these pesticides was tested in two studies in Wistar rats, showing mixture effects in good agreement with the additivity predictions...
May 16, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28450750/environmental-influences-on-ovarian-dysgenesis-developmental-windows-sensitive-to-chemical-exposures
#2
REVIEW
Hanna Katarina Lilith Johansson, Terje Svingen, Paul A Fowler, Anne Marie Vinggaard, Julie Boberg
A woman's reproductive health and ability to have children directly affect numerous aspects of her life, from personal well-being and socioeconomic standing, to morbidity and lifespan. In turn, reproductive health depends on the development of correctly functioning ovaries, a process that starts early during fetal life. Early disruption to ovarian programming can have long-lasting consequences, potentially manifesting as disease much later in adulthood. A growing body of evidence suggests that exposure to chemicals early in life, including endocrine-disrupting chemicals, can cause a range of disorders later in life, such as those described in the ovarian dysgenesis syndrome hypothesis...
April 28, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28396165/commentary-role-of-mesenchymal-stromal-cell-mediated-crosstalk-with-macrophages-in-graft-versus-host-disease-and-tissue-repair
#3
Lindsay C Davies, Erik Boberg, Katarina Le Blanc
No abstract text is available yet for this article.
April 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28390501/internet-based-extinction-therapy-for-worry-a-randomized-controlled-trial
#4
Erik Andersson, Erik Hedman, Olle Wadström, Julia Boberg, Emil Yaroslav Andersson, Erland Axelsson, Johan Bjureberg, Timo Hursti, Brjánn Ljótsson
Worry is a common phenotype in both psychiatric patients and the normal population. Worry can be seen as a covert behavior with primary function to avoid aversive emotional experiences. Our research group has developed a treatment protocol based on an operant model of worry, where we use exposure-based strategies to extinguish the catastrophic worry thoughts. The aim of this study was to test this treatment delivered via the Internet in a large-scale randomized controlled trial. We randomized 140 high-worriers (defined as > 56 on the Penn State Worry Questionnaire [PSWQ]) to either Internet-based extinction therapy (IbET) or to a waiting-list condition (WL)...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28274849/patient-age-sex-and-inflammatory-bowel-disease-phenotype-associate-with-course-of-primary-sclerosing-cholangitis
#5
Tobias J Weismüller, Palak J Trivedi, Annika Bergquist, Mohamad Imam, Henrike Lenzen, Cyriel Y Ponsioen, Kristian Holm, Daniel Gotthardt, Martti A Färkkilä, Hanns-Ulrich Marschall, Douglas Thorburn, Rinse K Weersma, Johan Fevery, Tobias Mueller, Olivier Chaouillères, Kornelius Schulze, Konstantinos N Lazaridis, Sven Almer, Stephen P Pereira, Cynthia Levy, Andrew Mason, Sigrid Naess, Christopher L Bowlus, Annarosa Floreani, Emina Halilbasic, Kidist K Yimam, Piotr Milkiewicz, Ulrich Beuers, Dep K Huynh, Albert Pares, Christine N Manser, George N Dalekos, Bertus Eksteen, Pietro Invernizzi, Christoph P Berg, Gabi I Kirchner, Christoph Sarrazin, Vincent Zimmer, Luca Fabris, Felix Braun, Marco Marzioni, Brian D Juran, Karouk Said, Christian Rupp, Kalle Jokelainen, Maria Benito de Valle, Francesca Saffioti, Angela Cheung, Michael Trauner, Christoph Schramm, Roger W Chapman, Tom H Karlsen, Erik Schrumpf, Christian P Strassburg, Michael P Manns, Keith D Lindor, Gideon M Hirschfield, Bettina E Hansen, Kirsten M Boberg
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC. METHODS: We performed a retrospective outcome analysis of patients diagnosed with PSC from 1980 through 2010 at 37 centers in Europe, North America, and Australia. For each patient, we collected data on sex, clinician-reported age at and date of PSC and IBD diagnoses, phenotypes of IBD and PSC, and date and indication of IBD-related surgeries...
March 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28267887/enhanced-liver-fibrosis-test-predicts-transplant-free-survival-in-primary-sclerosing-cholangitis-a-multi-centre-study
#6
Elisabeth M G de Vries, Martti Färkkilä, Piotr Milkiewicz, Johannes R Hov, Bertus Eksteen, Douglas Thorburn, Olivier Chazouillères, Albert Pares, Ståle Nygård, Odd H Gilja, Ewa Wunsch, Pietro Invernizzi, Marco Carbone, Francesca Bernuzzi, Kirsten M Boberg, Helge Røsjø, William Rosenberg, Ulrich H Beuers, Cyriel Y Ponsioen, Tom H Karlsen, Mette Vesterhus
BACKGROUND & AIMS: Biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC) have not been firmly established. Enhanced liver fibrosis (ELF) test was previously reported to predict outcome in PSC. We aimed to validate the prognostic utility of ELF test in an independent, multi-centre, retrospective PSC study population. METHODS: We collected serum samples from PSC patients from seven countries. We estimated rates of transplant-free survival by the Kaplan-Meier method, used Cox proportional hazards regression to explore the association between ELF test and clinical outcome and determined prognostic performance of ELF test by computing the area under the receiver operating characteristic (AUC-ROC) curve...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28161472/novel-serum-and-bile-protein-markers-predict-primary-sclerosing-cholangitis-disease-severity-and-prognosis
#7
Mette Vesterhus, Anders Holm, Johannes Roksund Hov, Ståle Nygård, Erik Schrumpf, Espen Melum, Liv Wenche Thorbjørnsen, Vemund Paulsen, Knut Lundin, Inge Dale, Odd Helge Gilja, Serge J L B Zweers, Morten Vatn, Frank G Schaap, Peter L M Jansen, Thor Ueland, Helge Røsjø, Bjørn Moum, Cyriel Y Ponsioen, Kirsten Muri Boberg, Martti Färkkilä, Tom H Karlsen, Fridtjof Lund-Johansen
BACKGROUND & AIMS: Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy. We aimed to identify novel protein biomarkers of disease severity and prognosis in primary sclerosing cholangitis (PSC). METHODS: Using a bead-based array targeting 63 proteins, we profiled a derivation panel of Norwegian endoscopic retrograde cholangiography bile samples (55 PSC, 20 disease controls) and a Finnish validation panel (34 PSC, 10 disease controls)...
June 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28150710/foliar-fungi-of-betula-pendula-impact-of-tree-species-mixtures-and-assessment-methods
#8
Diem Nguyen, Johanna Boberg, Michelle Cleary, Helge Bruelheide, Lydia Hönig, Julia Koricheva, Jan Stenlid
Foliar fungi of silver birch (Betula pendula) in an experimental Finnish forest were investigated across a gradient of tree species richness using molecular high-throughput sequencing and visual macroscopic assessment. We hypothesized that the molecular approach detects more fungal taxa than visual assessment, and that there is a relationship among the most common fungal taxa detected by both techniques. Furthermore, we hypothesized that the fungal community composition, diversity, and distribution patterns are affected by changes in tree diversity...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27992413/genome-wide-association-study-of-primary-sclerosing-cholangitis-identifies-new-risk-loci-and-quantifies-the-genetic-relationship-with-inflammatory-bowel-disease
#9
Sun-Gou Ji, Brian D Juran, Sören Mucha, Trine Folseraas, Luke Jostins, Espen Melum, Natsuhiko Kumasaka, Elizabeth J Atkinson, Erik M Schlicht, Jimmy Z Liu, Tejas Shah, Javier Gutierrez-Achury, Kirsten M Boberg, Annika Bergquist, Severine Vermeire, Bertus Eksteen, Peter R Durie, Martti Farkkila, Tobias Müller, Christoph Schramm, Martina Sterneck, Tobias J Weismüller, Daniel N Gotthardt, David Ellinghaus, Felix Braun, Andreas Teufel, Mattias Laudes, Wolfgang Lieb, Gunnar Jacobs, Ulrich Beuers, Rinse K Weersma, Cisca Wijmenga, Hanns-Ulrich Marschall, Piotr Milkiewicz, Albert Pares, Kimmo Kontula, Olivier Chazouillères, Pietro Invernizzi, Elizabeth Goode, Kelly Spiess, Carmel Moore, Jennifer Sambrook, Willem H Ouwehand, David J Roberts, John Danesh, Annarosa Floreani, Aliya F Gulamhusein, John E Eaton, Stefan Schreiber, Catalina Coltescu, Christopher L Bowlus, Velimir A Luketic, Joseph A Odin, Kapil B Chopra, Kris V Kowdley, Naga Chalasani, Michael P Manns, Brijesh Srivastava, George Mells, Richard N Sandford, Graeme Alexander, Daniel J Gaffney, Roger W Chapman, Gideon M Hirschfield, Mariza de Andrade, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Carl A Anderson
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A...
February 2017: Nature Genetics
https://www.readbyqxmd.com/read/27895113/age-dependent-absolute-abundance-of-hepatic-carboxylesterases-ces1-and-ces2-by-lc-ms-ms-proteomics-application-to-pbpk-modeling-of-oseltamivir-in-vivo-pharmacokinetics-in-infants
#10
Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J Steven Leeder, Bhagwat Prasad
The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in human liver was investigated and applied to predict infant pharmacokinetics (PK) of oseltamivir. The CES absolute protein abundance was determined by liquid chromatography-tandem mass spectrometry proteomics in human liver microsomal and cytosolic fractions prepared from tissue samples obtained from 136 pediatric donors and 35 adult donors. Two surrogate peptides per protein were selected for the quantification of CES1 and CES2 protein abundance...
February 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27647428/gut-and-liver-t-cells-of-common-clonal-origin-in-primary-sclerosing-cholangitis-inflammatory-bowel-disease
#11
Eva Kristine Klemsdal Henriksen, Kristin Kaasen Jørgensen, Fatemeh Kaveh, Kristian Holm, David Hamm, Johanna Olweus, Espen Melum, Brian K Chung, Tor J Eide, Knut E A Lundin, Kirsten Muri Boberg, Tom H Karlsen, Gideon M Hirschfield, Evaggelia Liaskou
BACKGROUND & AIMS: Recruitment of gut-derived memory T-cells to the liver is believed to drive hepatic inflammation in primary sclerosing cholangitis (PSC). However, whether gut-infiltrating and liver-infiltrating T-cells share T cell receptors (TCRs) and antigenic specificities is unknown. We used paired gut and liver samples from PSC patients with concurrent inflammatory bowel disease (PSC-IBD), and normal tissue samples from colon cancer controls, to assess potential T cell clonotype overlap between the two compartments...
January 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/27592323/low-dose-developmental-exposure-to-bisphenol-a-alters-the-femoral-bone-geometry-in-wistar-rats
#12
M H Lejonklou, S Christiansen, J Örberg, L Shen, S Larsson, J Boberg, U Hass, P M Lind
BACKGROUND: Bisphenol A (BPA) is a chemical produced in large volumes for use in manufacturing of consumer products and industrial applications, and an endocrine disruptor known to affect several hormonal systems. Bone produces hormones and is additionally a sensitive hormone target tissue, and is thus potentially sensitive to low doses of endocrine disruptors such as BPA, especially during development. METHODS: 110 pregnant Wistar rats were gavaged with 0; 25 μg; 250 μg; 5000 μg or 50,000 μg BPA/kg bodyweight (bw)/day from gestational day 7 until weaning at postnatal day 22...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27558072/antineutrophil-antibodies-define-clinical-and-genetic-subgroups-in-primary-sclerosing-cholangitis
#13
Johannes R Hov, Kirsten M Boberg, Eli Taraldsrud, Mette Vesterhus, Maria Boyadzhieva, Inger Camilla Solberg, Erik Schrumpf, Morten H Vatn, Benedicte A Lie, Øyvind Molberg, Tom H Karlsen
BACKGROUND & AIMS: The strongest genetic risk factors in primary sclerosing cholangitis (PSC) are encoded in the HLA complex. Antineutrophil cytoplasmic antibodies (ANCA) have been reported in up to 94% of PSC patients, but their clinical significance and immunogenetic basis are ill defined. We aimed to characterize clinical and genetic associations of ANCA in PSC. METHODS: Antineutrophil cytoplasmic antibodies were analysed with indirect immunofluorescence in 241 Norwegian PSC patients...
March 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27523804/corrigendum-to-reproductive-and-behavioral-effects-of-diisononyl-phthalate-dinp-in-perinatally-exposed-rats-reprod-toxicol-31-2-2011-200-209
#14
Julie Boberg, Sofie Christiansen, Marta Axelstad, Thuri Seidler Kledal, Anne Marie Vinggaard, Majken Dalgaard, Christine Nellemann, Ulla Hass
No abstract text is available yet for this article.
August 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27521513/no-evidence-that-azathioprine-increases-risk-of%C3%A2-cholangiocarcinoma-in-patients-with-primary-sclerosing%C3%A2-cholangitis
#15
Roman Zenouzi, Tobias J Weismüller, Kristin K Jørgensen, Michael Bubenheim, Henrike Lenzen, Peter Hübener, Kornelius Schulze, Christina Weiler-Normann, Marcial Sebode, Hanno Ehlken, Nadine Pannicke, Johannes Hartl, Moritz Peiseler, Sina Hübener, Tom H Karlsen, Kirsten M Boberg, Michael P Manns, Ansgar W Lohse, Christoph Schramm
BACKGROUND & AIMS: Patients with primary sclerosing cholangitis (PSC) are at increased risk for developing cholangiocarcinoma (CCA). Patients with PSC also can have inflammatory bowel diseases (IBDs) or features of autoimmune hepatitis (AIH), and therefore are treated with azathioprine. Azathioprine has been associated with an increased risk for malignancy, therefore we investigated whether azathioprine use affects the risk of CCA in persons with PSC. METHODS: We performed a retrospective study of well-defined patients with PSC using data collected from 3 large-volume, tertiary care centers in Germany and Norway...
August 10, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27500239/indications-and-outcomes-in-liver-transplantation-in-patients-with-primary-sclerosing-cholangitis-in-norway
#16
Ina M Andersen, Bjarte Fosby, Kirsten M Boberg, Ole P F Clausen, Peter Jebsen, Espen Melum, Pål D Line, Aksel Foss, Erik Schrumpf, Tom H Karlsen
BACKGROUND: Primary sclerosing cholangitis (PSC) is 1 of the leading causes of liver transplantation (LTX) in Scandinavia, and an increasing number of PSC patients have been transplanted in Norway during the last 2 decades. This trend is partly attributable to the recently established practice in Norway of offering LTX to PSC patients with cholangiocellular dysplasia. Based on the controversy associated with this practice, we herein aimed to report the main features and outcomes of our LTX program in PSC...
October 2015: Transplantation Direct
https://www.readbyqxmd.com/read/27429392/gunn-s-dots-in-retinal-images-of-2-286-adolescents-prevalence-retinal-distribution-and-associations
#17
Lars C Boberg-Ans, Inger C Munch, Michael Larsen, Bamini Gopinath, Jie Jin Wang, Paul Mitchell
PURPOSE: To investigate the epidemiology of Gunn's dots and their associations in a population-based cohort of children. METHODS: Red-free fundus photographs from 2,286 children aged 11 years to 14 years from the Sydney Myopia Study were graded. Gunn's dots were manually marked and counted within a 6 mm grid centered on the optic disc. RESULTS: One or more Gunn's dots were seen in at least one eye in 82.6% of children. The median number of Gunn's dots per eye was 46 (range 0-482)...
February 2017: Retina
https://www.readbyqxmd.com/read/27122241/multiple-endocrine-disrupting-effects-in-rats-perinatally-exposed-to-butylparaben
#18
J Boberg, M Axelstad, T Svingen, K Mandrup, S Christiansen, A M Vinggaard, U Hass
Parabens comprise a group of preservatives commonly added to cosmetics, lotions, and other consumer products. Butylparaben has estrogenic and antiandrogenic properties and is known to reduce sperm counts in rats following perinatal exposure. Whether butylparaben exposure can affect other endocrine sensitive endpoints, however, remains largely unknown. In this study, time-mated Wistar rats (n = 18) were orally exposed to 0, 10, 100, or 500 mg/kg bw/d of butylparaben from gestation day 7 to pup day 22. Several endocrine-sensitive endpoints were adversely affected...
July 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27095655/expert-consensus-document-cholangiocarcinoma-current-knowledge-and-future-perspectives-consensus-statement-from-the-european-network-for-the-study-of-cholangiocarcinoma-ens-cca
#19
Jesus M Banales, Vincenzo Cardinale, Guido Carpino, Marco Marzioni, Jesper B Andersen, Pietro Invernizzi, Guro E Lind, Trine Folseraas, Stuart J Forbes, Laura Fouassier, Andreas Geier, Diego F Calvisi, Joachim C Mertens, Michael Trauner, Antonio Benedetti, Luca Maroni, Javier Vaquero, Rocio I R Macias, Chiara Raggi, Maria J Perugorria, Eugenio Gaudio, Kirsten M Boberg, Jose J G Marin, Domenico Alvaro
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level...
May 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27089241/low-dose-effect-of-developmental-bisphenol-a-exposure-on-sperm-count-and-behaviour-in-rats
#20
U Hass, S Christiansen, J Boberg, M G Rasmussen, K Mandrup, M Axelstad
Bisphenol A is widely used in food contact materials and other products and is detected in human urine and blood. Bisphenol A may affect reproductive and neurological development; however, opinion of the European Food Safety Authority (EFSA) on bisphenol A (EFSA J, 13, 2015 and 3978) concluded that none of the available studies were robust enough to provide a point of departure for setting a tolerable daily intake for bisphenol A. In the present study, pregnant Wistar rats (n = 17-21) were gavaged from gestation day 7 to pup day 22 with bisphenol A doses of 0, 25 μg, 250 μg, 5 mg or 50 mg/kg bw/day...
July 2016: Andrology
keyword
keyword
92263
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"