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JOURNAL ARTICLE
Sebastian Malmqvist, Patrik Strandberg, Ida Victorin, Emelie Boberg, Annsofi Johannsen
OBJECTIVE: To what extent do dental hygienists (DH) employed by the Public Dental Health Service (PDHS) in Sweden use the new classification system, their knowledge of it and their attitudes towards it. METHODS: A web-based questionnaire was distributed to DHs in the PDHS in different regions of Sweden. A total of 197 registered DHs responded. The questions covered their knowledge, attitudes and possible barriers to implementation of the new classification system of periodontal and peri-implant diseases, and a question about their perceived need for a complementary digital tool to facilitate its implementation...
May 9, 2024: International Journal of Dental Hygiene
#2
Nora I Strom, Zachary F Gerring, Marco Galimberti, Dongmei Yu, Matthew W Halvorsen, Abdel Abdellaoui, Cristina Rodriguez-Fontenla, Julia M Sealock, Tim Bigdeli, Jonathan R Coleman, Behrang Mahjani, Jackson G Thorp, Katharina Bey, Christie L Burton, Jurjen J Luykx, Gwyneth Zai, Silvia Alemany, Christine Andre, Kathleen D Askland, Nerisa Banaj, Cristina Barlassina, Judith Becker Nissen, O Joseph Bienvenu, Donald Black, Michael H Bloch, Julia Boberg, Sigrid Børte, Rosa Bosch, Michael Breen, Brian P Brennan, Helena Brentani, Joseph D Buxbaum, Jonas Bybjerg-Grauholm, Enda M Byrne, Judit Cabana-Dominguez, Beatriz Camarena, Adrian Camarena, Carolina Cappi, Angel Carracedo, Miguel Casas, Maria Cristina Cavallini, Valentina Ciullo, Edwin H Cook, Jesse Crosby, Bernadette A Cullen, Elles J De Schipper, Richard Delorme, Srdjan Djurovic, Jason A Elias, Xavier Estivill, Martha J Falkenstein, Bengt T Fundin, Lauryn Garner, Chris German, Christina Gironda, Fernando S Goes, Marco A Grados, Jakob Grove, Wei Guo, Jan Haavik, Kristen Hagen, Kelly Harrington, Alexandra Havdahl, Kira D Höffler, Ana G Hounie, Donald Hucks, Christina Hultman, Magdalena Janecka, Eric Jenike, Elinor K Karlsson, Kara Kelley, Julia Klawohn, Janice E Krasnow, Kristi Krebs, Christoph Lange, Nuria Lanzagorta, Daniel Levey, Kerstin Lindblad-Toh, Fabio Macciardi, Brion Maher, Brittany Mathes, Evonne McArthur, Nathaniel McGregor, Nicole C McLaughlin, Sandra Meier, Euripedes C Miguel, Maureen Mulhern, Paul S Nestadt, Erika L Nurmi, Kevin S O'Connell, Lisa Osiecki, Olga Therese Ousdal, Teemu Palviainen, Nancy L Pedersen, Fabrizio Piras, Federica Piras, Sriramya Potluri, Raquel Rabionet, Alfredo Ramirez, Scott Rauch, Abraham Reichenberg, Mark A Riddle, Stephan Ripke, Maria C Rosário, Aline S Sampaio, Miriam A Schiele, Anne Heidi Skogholt, Laura G Sloofman G Sloofman, Jan Smit, María Soler Artigas, Laurent F Thomas, Eric Tifft, Homero Vallada, Nathanial van Kirk, Jeremy Veenstra-VanderWeele, Nienke N Vulink, Christopher P Walker, Ying Wang, Jens R Wendland, Bendik S Winsvold, Yin Yao, Hang Zhou, Arpana Agrawal, Pino Alonso, Götz Berberich, Kathleen K Bucholz, Cynthia M Bulik, Danielle Cath, Damiaan Denys, Valsamma Eapen, Howard Edenberg, Peter Falkai, Thomas V Fernandez, Abby J Fyer, J M Gaziano, Dan A Geller, Hans J Grabe, Benjamin D Greenberg, Gregory L Hanna, Ian B Hickie, David M Hougaard, Norbert Kathmann, James Kennedy, Dongbing Lai, Mikael Landén, Stéphanie Le Hellard, Marion Leboyer, Christine Lochner, James T McCracken, Sarah E Medland, Preben B Mortensen, Benjamin M Neale, Humberto Nicolini, Merete Nordentoft, Michele Pato, Carlos Pato, David L Pauls, John Piacentini, Christopher Pittenger, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Steven A Rasmussen, Margaret A Richter, David R Rosenberg, Stephan Ruhrmann, Jack F Samuels, Sven Sandin, Paul Sandor, Gianfranco Spalletta, Dan J Stein, S Evelyn Stewart, Eric A Storch, Barbara E Stranger, Maurizio Turiel, Thomas Werge, Ole A Andreassen, Anders D Børglum, Susanne Walitza, Kristian Hveem, Bjarne K Hansen, Christian P Rück, Nicholas G Martin, Lili Milani, Ole Mors, Ted Reichborn-Kjennerud, Marta Ribasés, Gerd Kvale, David Mataix-Cols, Katharina Domschke, Edna Grünblatt, Michael Wagner, John-Anker Zwart, Gerome Breen, Gerald Nestadt, Jaakko Kaprio, Paul D Arnold, Dorothy E Grice, James A Knowles, Helga Ask, Karin J Verweij, Lea K Davis, Dirk J Smit, James J Crowley, Jeremiah M Scharf, Murray B Stein, Joel Gelernter, Carol A Mathews, Eske M Derks, Manuel Mattheisen
Obsessive-compulsive disorder (OCD) affects ∼1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on the genetic etiology and underlying biological mechanisms of the disorder. We conducted a GWAS meta-analysis combining 53,660 OCD cases and 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent genome-wide significant SNPs and a SNP-based heritability of 6.7%. Separate GWAS for clinical, biobank, comorbid, and self-report sub-groups found no evidence of sample ascertainment impacting our results...
March 13, 2024: medRxiv
#3
Erik Boberg, Anders Hedman, Jacob Hollenberg
BACKGROUND: Pulmonary embolism (PE) is the leading cause of in-hospital death and the third most frequent cause of cardiovascular death. The clinical presentation of PE is variable, and choosing the appropriate treatment for individual patients can be challenging. CASE SUMMARY: A 64-year-old man presented to hospital with acute chest pain, shortness of breath, and pulmonary oedema. Electrocardiogram revealed ST-elevation myocardial infarction. D-dimer was 18.8 mg/L fibrinogen equivalent units (FEU) (normal <0...
April 2024: European Heart Journal. Case Reports
#4
Nora I Strom, Matthew W Halvorsen, Chao Tian, Christian Rück, Gerd Kvale, Bjarne Hansen, Jonas Bybjerg-Grauholm, Jakob Grove, Julia Boberg, Judith Becker Nissen, Thomas Damm Als, Thomas Werge, Elles de Schipper, Bengt Fundin, Christina Hultman, Kira D Höffler, Nancy Pedersen, Sven Sandin, Cynthia Bulik, Mikael Landén, Elinor Karlsson, Kristen Hagen, Kerstin Lindblad-Toh, David M Hougaard, Sandra M Meier, Stéphanie Le Hellard, Ole Mors, Anders D Børglum, Jan Haavik, David A Hinds, David Mataix-Cols, James J Crowley, Manuel Mattheisen
To date, four genome-wide association studies (GWAS) of obsessive-compulsive disorder (OCD) have been published, reporting a high single-nucleotide polymorphism (SNP)-heritability of 28% but finding only one significant SNP. A sub-stantial increase in sample size will likely lead to further identification of SNPs, genes, and biological pathways mediating the susceptibility to OCD. We conducted a GWAS meta-analysis with a 2-3-fold increase in case sample size (OCD cases: N = 37,015, controls: N = 948,616) compared to the last OCD GWAS, including six previously published cohorts (OCGAS, IOCDF-GC, IOCDF-GC-trio, NORDiC-nor, NORDiC-swe, and iPSYCH) and unpublished self-report data from 23andMe Inc...
March 8, 2024: medRxiv
#5
JOURNAL ARTICLE
Gabriel Riva, Erik Boberg, Mattias Ringh, Martin Jonsson, Andreas Claesson, Anette Nord, Sten Rubertsson, Hans Blomberg, Per Nordberg, Sune Forsberg, Mårten Rosenqvist, Leif Svensson, Cecilia Andréll, Johan Herlitz, Jacob Hollenberg
BACKGROUND: The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest. This pilot study assesses feasibility, safety, and intermediate clinical outcomes as part of the larger TANGO2 survival trial. METHODS: Emergency medical dispatch calls of suspected out-of-hospital cardiac arrest were screened for inclusion at 18 dispatch centers in Sweden between January 1, 2017, and March 12, 2020...
March 6, 2024: Circulation. Cardiovascular Quality and Outcomes
#6
JOURNAL ARTICLE
Konrad Scheffler, Marija Boberg, Tobias Knopp
In the field of medical imaging, Magnetic Particle Imaging (MPI) poses a promising non-ionizing tomographic technique with high spatial and temporal resolution. In MPI, iterative solvers are used to reconstruct the particle distribution out of the measured voltage signal based on a system matrix. The amount of regularization needed to reconstruct an image of good quality differs from measurement to measurement, depending on the MPI system and the measurement settings. Finding the right choice for the three major parameters controlling the regularization is commonly done by hand and requires time and experience...
January 24, 2024: Physics in Medicine and Biology
#7
Matthew Halvorsen, Elles de Schipper, Julia Boberg, Nora Strom, Kristen Hagen, Kerstin Lindblad-Toh, Elinor Karlsson, Nancy Pedersen, Cynthia Bulik, Bengt Fundín, Mikael Landén, Gerd Kvale, Bjarne Hansen, Jan Haavik, Manuel Mattheisen, Christian Rück, David Mataix-Cols, James Crowley
Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common single nucleotide variants (SNVs), along with rare coding SNVs and small insertion-deletions (indels). The contribution to OCD risk from large, rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. Here we describe an analysis of rare CNVs called from genotype array data in 2,248 deeply phenotyped OCD cases and 3,608 unaffected controls from Sweden and Norway...
January 3, 2024: Research Square
#8
JOURNAL ARTICLE
Michael G Diemar, Mathieu Vinken, Marc Teunis, Cyrille A M Krul, Francois Busquet, Julia Dominika Zajac, Helena Kandarova, Raffaella Corvi, Matteo Z Rossi, Anastasiia Kharina, Louise Stab Bryndum, Michael Santillo, Denise Bloch, Olena Kucheryavenko, Demosthenes Panagiotakos, Vera Rogiers, Manon Beekhuijzen, Arianna Giusti, Abdulkarim Najjar, Carol Courage, Torben Koenig, Susanne Kolle, Harrie Boonen, Stephane Dhalluin, Julie Boberg, Boris P Müller, Predrag Kukic, Merel Ritskes-Hoitinga, Elena Grasselli, Tamara Zietek, Gilly Stoddart, Harm J Heusinkveld, Jose V Castell, Emilio Benfenati, Huan Yang, Simón Perera, Alicia Paini, Nynke I Kramer, Thomas Hartung, Manoe Janssen, Ellen Fritsche, Danyel G J Jennen, Matteo Piumatti, James Rathman, Jörg Marusczyk, Lucia Milec, Erwin L Roggen
The first Stakeholder Network Meeting of the EU Horizon 2020-funded ONTOX project was held on 13-14 March 2023, in Brussels, Belgium. The discussion centred around identifying specific challenges, barriers and drivers in relation to the implementation of non-animal new approach methodologies (NAMs) and probabilistic risk assessment (PRA), in order to help address the issues and rank them according to their associated level of difficulty. ONTOX aims to advance the assessment of chemical risk to humans, without the use of animal testing, by developing non-animal NAMs and PRA in line with 21st century toxicity testing principles...
January 18, 2024: Alternatives to Laboratory Animals: ATLA
#9
JOURNAL ARTICLE
Trevor Barrett, Robert Faulk, Army Master Sergeant, Jill Boberg, Matthew Bartels, Marine Lieutenant Colonel, Leslie A Saxon
The ability to obtain dynamic movement assessments using force plate technology holds the promise of providing more detailed knowledge of the strength, balance and forces generated by active-duty military personnel. To date, there are not well-defined use cases for implementation of force plate assessments in military training environments. We sought to determine if force plate technology assessments could provide additional insights, related to the likelihood of graduation, beyond that provided by traditional physical fitness tests (PFT's), in an elite Marine training school...
January 13, 2024: BMC Sports Science, Medicine and Rehabilitation
#10
JOURNAL ARTICLE
Julie Boberg, Tianyi Li, Sofie Christiansen, Monica K Draskau, Pauliina Damdimopoulou, Terje Svingen, Hanna K L Johansson
A prevailing challenge when testing chemicals for their potential to cause female reproductive toxicity is the lack of appropriate toxicological test methods. We hypothesized that starting a 28-day in vivo toxicity study already at weaning, instead of in adulthood, would increase the sensitivity to detect endocrine disruptors due to the possibility of including assessment of pubertal onset. We compared the sensitivity of two rat studies using pubertal or adult exposure. We exposed the rats to two well-known human endocrine disruptors, the estrogen diethylstilbestrol (DES; 0...
2023: Frontiers in Endocrinology
#11
JOURNAL ARTICLE
Julia Boberg, Viktor Kaldo, David Mataix-Cols, James J Crowley, Bjorn Roelstraete, Matthew Halvorsen, Erik Forsell, Nils H Isacsson, Patrick F Sullivan, Cecilia Svanborg, Evelyn H Andersson, Nils Lindefors, Olly Kravchenko, Manuel Mattheisen, Hilda B Danielsdottir, Ekaterina Ivanova, Magnus Boman, Lorena Fernández de la Cruz, John Wallert, Christian Rück
PURPOSE: Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data...
October 4, 2023: BMJ Open
#12
JOURNAL ARTICLE
Ying Xiong, Robert Karlsson, Jie Song, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C Clements, Evelyn Andersson, Julia Boberg, Cathryn M Lewis, Patrick F Sullivan, Mikael Landén, Yi Lu
Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed to derive a stringent definition of treatment resistance and to investigate the genetic overlap between treatment response and resistance in MDD. Using electronic medical records on the use of antidepressants and electroconvulsive therapy (ECT) from Swedish registers, we derived the phenotype of treatment-resistant depression (TRD) and non-TRD within ~4500 individuals with MDD in three Swedish cohorts...
September 28, 2023: Translational Psychiatry
#13
JOURNAL ARTICLE
Anna Thorén, Martin Jonsson, Martin Spångfors, Eva Joelsson-Alm, Jan Jakobsson, Araz Rawshani, Thomas Kahan, Johan Engdahl, Arvid Jadenius, Erik Boberg von Platen, Johan Herlitz, Therese Djärv
INTRODUCTION: Rapid response teams (RRTs) are designed to improve the "chain of prevention" of in-hospital cardiac arrest (IHCA). We studied the 30-day survival of patients reviewed by RRTs within 24 hours prior to IHCA, as compared to patients not reviewed by RRTs. METHODS: A nationwide cohort study based on the Swedish Registry of Cardiopulmonary Resuscitation, between January 1st, 2014, and December 31st, 2021. An explorative, hypothesis-generating additional in-depth data collection from medical records was performed in a small subgroup of general ward patients reviewed by RRTs...
September 22, 2023: Resuscitation
#14
REVIEW
Janni M E Larsson, Lars C Boberg-Ans, Andreas Vangsted, Elon H C van Dijk, Jakob Grauslund, Javad N Hajari, Oliver N Klefter, Miklos Schneider, Yousif Subhi
Central serous chorioretinopathy (CSC) is a prevalent exudative maculopathy and the ongoing verteporfin shortage restricts current treatment possibilities. Topical non-steroidal anti-inflammatory drugs (NSAID) have previously been proposed as a treatment for CSC, although its exact efficacy remains unclear. In this systematic review and meta-analysis, we outlined the efficacy of topical NSAIDs for the treatment of CSC. We searched 11 literature databases on 13 December 2022, for any study describing topical NSAID treatment for CSC...
August 8, 2023: Acta Ophthalmologica
#15
JOURNAL ARTICLE
Petter Gjersvik, Ragnhild S Falk, Ingrid Roscher, Syed Mohammad Husain Rizvi, Geir Mjøen, Einar Gude, Inga Leuckfeld, Kirsten Muri Boberg, Marit B Veierød, Trude Eid Robsahm
IMPORTANCE: Cutaneous squamous cell carcinoma (cSCC) may occur with multiple primary tumors, metastasize, and cause death both in immunocompetent and immunosuppressed patients. OBJECTIVE: To study the rates of second cSCC, metastasis, and death from cSCC in patients with and without organ transplant-associated immunosuppressive treatment. DESIGN, SETTING, AND PARTICIPANTS: This population-based, nationwide cohort study used Cancer Registry of Norway data from 47 992 individuals diagnosed with cSCC at 18 years or older between January 1, 1968, and December 31, 2020...
September 1, 2023: JAMA Dermatology
#16
JOURNAL ARTICLE
Sarah E McFarland, Ulrich Marcus, Lukas Hemmers, Fuminari Miura, Jesús Iñigo Martínez, Fernando Martín Martínez, Elisa Gil Montalbán, Emilie Chazelle, Alexandra Mailles, Yassoungo Silue, Naïma Hammami, Amaryl Lecompte, Nicolas Ledent, Wim Vanden Berghe, Laurens Liesenborghs, Dorien Van den Bossche, Paul R Cleary, Jacco Wallinga, Eve P Robinson, Tone Bjordal Johansen, Antra Bormane, Tanya Melillo, Cornelia Seidl, Liza Coyer, Ronja Boberg, Annette Jurke, Dirk Werber, Alexander Bartel
BackgroundSince May 2022, an mpox outbreak affecting primarily men who have sex with men (MSM) has occurred in numerous non-endemic countries worldwide. As MSM frequently reported multiple sexual encounters in this outbreak, reliably determining the time of infection is difficult; consequently, estimation of the incubation period is challenging.AimWe aimed to provide valid and precise estimates of the incubation period distribution of mpox by using cases associated with early outbreak settings where infection likely occurred...
July 2023: Euro Surveillance
#17
JOURNAL ARTICLE
Lars C Boberg-Ans, Oliver N Klefter, Marie L R Rasmussen, Elon H C van Dijk, Yousif Subhi
BACKGROUND: Systematic literature searches are the cornerstone of systematic reviews. In this study, we evaluated database coverage of randomized clinical trials for central serous chorioretinopathy (CSC). METHODS: We searched 12 databases (BIOSIS Previews, CINAHL, the Cochrane Central, Current Contents Connect, Data Citation Index, Derwent Innovations Index, EMBASE, KCI-Korean Journal Database, MEDLINE, PubMed, SciELO Citation Index, and Web of Science Core Collection) on 10 April 2023 for randomized clinical trials for CSC...
June 12, 2023: Journal of Personalized Medicine
#18
RANDOMIZED CONTROLLED TRIAL
Doerte U Junghaenel, Stefan Schneider, Gale Lucas, Jill Boberg, Faye M Weinstein, Steven H Richeimer, Arthur A Stone, Mark A Lumley
OBJECTIVE: Seminal advances in virtual human (VH) technology have introduced highly interactive, computer-animated VH interviewers. Their utility for aiding in chronic pain care is unknown. We developed three interactive telehealth VH interviews-a standard pain-focused, a psychosocial risk factor, and a pain psychology and neuroscience educational interview. We then conducted a preliminary investigation of their feasibility, acceptability, and efficacy. We also experimentally compared a human and a computer-generated VH voice...
September 1, 2023: Psychosomatic Medicine
#19
JOURNAL ARTICLE
Nina Boberg-Fazlic, Peter Sandholt Jensen, Markus Lampe, Paul Sharp, Christian Volmar Skovsgaard
UNLABELLED: We explore the role of elites for development and the spread of industrialized dairying in Denmark in the 1880s. We demonstrate that the location of early proto-modern dairies, introduced by landowning elites from northern Germany in the eighteenth century, explains the location of industrialized dairying in 1890: an increase of one standard deviation in elite influence increases industrialized dairying by 56 percent of the mean exposure in one specification. We interpret this as evidence for a spread of ideas from the elites to the peasantry, which we capture through measures of specialization in dairying and demand for education and identify a causal relationship using an instrument based on distance to the influential first mover...
April 3, 2023: Journal of Economic Growth
#20
JOURNAL ARTICLE
Tianyi Li, Julie Boberg, Hanna K L Johansson, Valentina Di Nisio, Sofie Christiansen, Terje Svingen, Pauliina Damdimopoulou
Female reproductive toxicity assessments rely on histological evaluation of ovaries by hematoxylin & eosin (H&E)-stained cross-sections. This is time-consuming, labor-intensive and costly, thus alternative methods for ovarian toxicity assessment could be valuable. Here, we report on an improved method based on quantification of antral follicles (AF) and corpora lutea (CL) using ovarian surface photographs, called 'surface photo counting' (SPC). To validate a potential utility for the method to detect effects on folliculogenesis in toxicity studies, we investigated ovaries from rats exposed to two well-known endocrine disrupting chemicals (EDCs), diethylstilbestrol (DES) and ketoconazole (KTZ)...
May 31, 2023: Reproductive Toxicology
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