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https://www.readbyqxmd.com/read/28107561/beta-blockers-for-hypertension
#1
REVIEW
Charles S Wiysonge, Hazel A Bradley, Jimmy Volmink, Bongani M Mayosi, Lionel H Opie
BACKGROUND: Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension. However, the benefit of beta-blockers as first-line therapy for hypertension without compelling indications is controversial...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28107397/efficacy-and-safety-of-everolimus-for-maintenance-immunosuppression-of-kidney-transplantation-a-meta-analysis-of-randomized-controlled-trials
#2
Jinyu Liu, Dong Liu, Juan Li, Lan Zhu, Chengliang Zhang, Kai Lei, Qiling Xu, Ruxu You
BACKGROUND: Conversion to everolimus is often used in kidney transplantation to overcome calcineurin inhibitor (CNI) nephrotoxicity but there is conflicting evidence for this approach. OBJECTIVES: To investigate the benefits and harm from randomized clinical trials (RCTs) involving the conversion from CNI to everolimus after kidney transplantation. METHODS: Databases were searched up to March 2016. Two reviewers independently assessed trials for eligibility and quality, and extracted data...
2017: PloS One
https://www.readbyqxmd.com/read/28107251/internet-delivered-self-management-support-for-improving-coronary-heart-disease-and-self-management-related-outcomes-a-systematic-review
#3
Jorge Palacios, Geraldine A Lee, Maria Duaso, Abigail Clifton, Ian J Norman, Derek Richards, Elizabeth Alexandra Barley
INTRODUCTION: Coronary heart disease (CHD) is associated with significant morbidity and mortality, including mental health comorbidity, which is associated with poor outcomes. Self-management is key, but there is limited access to self-management support. Internet-delivered interventions may increase access. OBJECTIVE: The aim of this study was to conduct a systematic review to (1) determine the effectiveness of Internet-delivered CHD self-management support for improving CHD, mood, and self-management related outcomes and (2) identify and describe essential components for effectiveness...
January 20, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28107234/comparison-between-acrylic-cage-and-polyetheretherketone-peek-cage-in-single-level-anterior-cervical-discectomy-and-fusion-a-randomized-clinical-trial
#4
Majid R Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized-controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral disks. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiological disk height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteointegration and stability, has not been identified yet...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28105573/effect-of-movement-velocity-during-resistance-training-on-dynamic-muscular-strength-a-systematic-review-and-meta-analysis
#5
REVIEW
Timothy B Davies, Kenny Kuang, Rhonda Orr, Mark Halaki, Daniel Hackett
BACKGROUND: Movement velocity is an acute resistance-training variable that can be manipulated to potentially optimize dynamic muscular strength development. However, it is unclear whether performing faster or slower repetitions actually influences dynamic muscular strength gains. OBJECTIVE: We conducted a systematic review and meta-analysis to examine the effect of movement velocity during resistance training on dynamic muscular strength. METHODS: Five electronic databases were searched using terms related to movement velocity and resistance training...
January 20, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28105066/electroacupuncture-for-the-prevention-of-postoperative-gastrointestinal-dysfunction-in-participants-undergoing-vascular-laparotomy-under-general-anesthesia-a-randomized-controlled-trial
#6
Meng-Yue Liu, Cheng-Wei Wang, Zhou-Peng Wu, Ning Li
BACKGROUND: Postoperative gastrointestinal dysfunction (PGD) is a common complication following laparotomy under general anesthesia (GA). Abdominal distension occurs in 8-28% of surgeries within 24 h postoperatively. The present study aimed to analyze the efficacy of electroacupuncture (EA) for the prevention of PGD by applying preoperative EA stimulation of PC6 (Neiguan), ST36 (Zusanli), and ST37 (Shangjuxv) bilaterally twice within 24 h prior to surgery, compared with no acupuncture treatment...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28104703/risk-factors-for-mortality-in-adult-patients-with-sickle-cell-disease-a-meta-analysis-of-studies-in-north-america-and-europe
#7
Poulami Maitra, Melissa Caughey, Laura Robinson, Payal C Desai, Susan Jones, Mehdi Nouraie, Mark T Gladwin, Alan Hinderliter, Jianwen Cai, Kenneth I Ataga
Although recent studies show an improved survival of children with sickle cell disease in the US and Europe, mortality remains high for adult patients. This study was conducted to evaluate the factors associated with mortality in adult patients following the approval of hydroxyurea. We first evaluated the association between selected variables and mortality at an academic center (UNC cohort). Data sources were then searched for publications from 1998 to June, 2016, with meta-analysis of eligible studies conducted in North America and Europe to evaluate the associations of selected variables with mortality in adult patients...
January 19, 2017: Haematologica
https://www.readbyqxmd.com/read/28104697/male-birthweight-semen-quality-and-birth-outcomes
#8
B W Whitcomb, M S Bloom, S Kim, Z Chen, G M Buck Louis
STUDY QUESTION: What are the relations among birthweight (BW), semen parameters and birth outcomes in a population-based sample? SUMMARY ANSWER: BW is unrelated to semen parameters, which are in turn unrelated to birth outcomes. WHAT IS KNOWN ALREADY: In clinical settings, there has been suggestion that semen parameters are related to BW when comparing fertile and infertile men; however, findings have been less clear in more general populations...
January 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28104210/9-month-clinical-and-angiographic-outcomes-of-the-cobra-polyzene-f-nanocoated-coronary-stent-system
#9
Donald E Cutlip, Kirk N Garratt, Victor Novack, Mark Barakat, Perwaiz Meraj, Luc Maillard, Andrejs Erglis, Rajiv Jauhar, Jeffrey J Popma, Robert Stoler, Sigmund Silber
OBJECTIVES: The aim of this study was to assess the safety and effectiveness of the COBRA Polyzene-F NanoCoated Coronary Stent System (CeloNova Biosciences, San Antonio, Texas) for the treatment of de novo coronary artery lesions. BACKGROUND: Polyzene-F-coated coronary stents have shown reduced thrombogenicity and inflammation in preclinical studies. METHODS: Patients with de novo coronary artery lesions meeting eligibility criteria were enrolled in a nonrandomized, prospective clinical trial...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28103974/-phase-i-study-of-etoposide-and-cisplatin-chemotherapy-dose-escalation-%C3%A2-with-concurrent-twice-daily-radiotherapy-for-patients-%C3%A2-with-limited-stage-small-cell-lung-cancer
#10
Jing You, Huiming Yu, Maxiaowei Song, Chen Shi, Xiaohang Wang, Ye Zheng, Rong Yu, Anhui Shi, Guangying Zhu
BACKGROUND: Concurrent twice-daily radiotherapy with chemotherapy of EP regimen is one of the current standard treatments for limited-stage small cell lung cancer. However, the safely tolerated dose of standard chemotherapy for Chinese patients is not decided. This study was to evaluate the toxicity and the maximum tolerated dose (MTD) of etoposide and cisplatin concurrent with thoracic radiation therapy for patients with limited-stage small cell lung cancer. METHODS: Patients with histologically proven limited-stage small cell lung cancer (LS-SCLC) were eligible...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28103710/radiography-and-abdominal-ct-compared-with-sacroiliac-joint-ct-in-the-diagnosis-of-sacroiliitis
#11
Julian Melchior, Yusef Azraq, Isabelle Chary-Valckenaere, Anne-Christine Rat, Pedro Texeira, Alain Blum, Damien Loeuille
Background The presence of structural sacroiliitis is strong evidence for the diagnosis of spondyloarthritis (SpA). Purpose To assess the performance of abdominal computed tomography (CT) and pelvic plain radiography for the diagnosis of structural sacroiliitis compared with sacroiliac CT (SI joint CT) considered the reference technique in patients with SpA. Material and Methods All SpA patients eligible for biologic treatment were selected from 2005 to 2012. An assessment of sacroiliitis was based on radiography according to the modified New York criteria and on abdominal CT and SI joint CT scans depending on the presence of erosion on at least two consecutive slices...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28103414/a-meta-analysis-of-the-association-between-appraisals-of-trauma-and-posttraumatic-stress-in-children-and-adolescents
#12
Ryan Mitchell, Kate Brennan, David Curran, Donncha Hanna, Kevin F W Dyer
Cognitive models of posttraumatic stress disorder (PTSD) place an emphasis on the role of negative appraisals of traumatic events. It is suggested that the way in which the event is appraised determines the extent to which posttraumatic stress symptoms will be experienced. Therefore, a strong relationship between trauma appraisals and symptoms of PTSD might be expected. However, this relationship is not as firmly established in the child and adolescent literature. A systematic literature review of this relationship returned 467 publications, of which 11 met full eligibility criteria...
January 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28103127/extracorporeal-cardiopulmonary-resuscitation-ecpr-in-the-prehospital-setting-an-illustrative-case-of-ecpr-performed-in-the-louvre-museum
#13
Lionel Lamhaut, Alice Hutin, Juliette Deutsch, Jean-Herlé Raphalen, Romain Jouffroy, Jean-Pierre Orsini, Frédéric Baud, Pierre Carli
INTRODUCTION: Extracorporeal Cardiopulmonary Resuscitation (ECPR) is now considered for the treatment of refractory cardiac arrest. CASE REPORT: In an urban city like Paris, extraction times of in-hospital ECPR can be long for patients presenting with refractory cardiac arrest. Using the medicalized prehospital system, we developed a possible early prehospital ECPR implementation. This case report is an example of ECPR prehospital implementation in the Louvre Museum...
January 19, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28102489/genetic-variants-and-anterior-cruciate-ligament-rupture-a-systematic-review
#14
REVIEW
Mustafa Kaynak, Frank Nijman, Joyce van Meurs, Max Reijman, Duncan E Meuffels
BACKGROUND: Studies have shown a familial predisposition for anterior cruciate ligament (ACL) rupture and have been followed by genetic-association studies on polymorphisms in candidate genes in recent years. To date, no systematic review with a best-evidence synthesis has evaluated the influence of genetics on this devastating knee injury. OBJECTIVE: Our objective was to evaluate the association between genetic variants and ACL rupture. METHODS: We performed an extensive search in Embase, MEDLINE, Web of Science, Scopus, PubMed Publisher, Cochrane Register of Clinical Trials, and Google scholar up to 24 August 2015...
January 19, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28102025/the-direct-referral-to-endovascular-center-criteria-a-proposal-for-pre-hospital-evaluation-of-acute-stroke-in-the-madrid-stroke-network
#15
J Rodríguez-Pardo, B Fuentes, M Alonso de Leciñana, Á Ximénez-Carrillo, G Zapata-Wainberg, J Álvarez-Fraga, F J Barriga, L Castillo, J Carneado-Ruiz, J Díaz-Guzman, J Egido-Herrero, A de Felipe, J Fernández-Ferro, L Frade-Pardo, Á García-Gallardo, A García-Pastor, A Gil-Núñez, C Gómez-Escalonilla, M Guillán, Y Herrero-Infante, J Masjuan-Vallejo, M Á Ortega-Casarrubios, J Vivancos-Mora, E Díez-Tejedor
BACKGROUND AND PURPOSE: For patients with acute ischaemic stroke due to large-vessel occlusion, it has recently been shown that mechanical thrombectomy (MT) with stent retrievers is better than medical treatment alone. However, few hospitals can provide MT 24 h/day 365 days/year, and it remains unclear whether selected patients with acute stroke should be directly transferred to the nearest MT-providing hospital to prevent treatment delays. Clinical scales such as Rapid Arterial Occlusion Evaluation (RACE) have been developed to predict large-vessel occlusion at a pre-hospital level, but their predictive value for MT is low...
January 19, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28100761/the-acceptability-of-self-sampled-screening-for-hpv-dna-a-systematic-review-and-meta-analysis
#16
REVIEW
Erik J Nelson, Brandy R Maynard, Travis Loux, Jessica Fatla, Rebecca Gordon, Lauren D Arnold
OBJECTIVE: To examine whether or not self-sampled cervical screening for human papillomavirus (HPV) DNA is acceptable and if women prefer self-sampling to clinician-based sampling. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Thirty-seven primary studies obtained through a comprehensive search of six electronic bibliographic databases from 1986 to 2014 and other sources. Search keywords included HPV, screening, DNA testing, vaginal testing, self-collected specimen, self-collected sample, self-sampling, self-screening, preferences and acceptability...
February 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28099873/antimicrobial-photodynamic-therapy-as-an-adjunct-for-treatment-of-deep-carious-lesions-a-systematic-review
#17
REVIEW
Fabian Cieplik, Wolfgang Buchalla, Elmar Hellwig, Ali Al-Ahmad, Karl-Anton Hiller, Tim Maisch, Lamprini Karygianni
For deep carious lesions, a more conservative treatment modality ("selective caries removal") has been proposed, where only the heavily contaminated dentine is removed. In this regard, effective adjuncts for cavity disinfection such as the antimicrobial photodynamic therapy (aPDT) can be valuable clinically prior to definitive restoration. Therefore, the aim of this study was to systematically assess clinical studies on the effectiveness of aPDT as a supplementary tool in the treatment of deep caries lesions...
January 15, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28099715/assessment-of-the-body-composition-of-patients-with-polycystic-ovary-syndrome-using-dual-energy-x-ray-absorptiometry
#18
Carolina F Macruz, Sônia M R R Lima, João E N Salles, Gustavo M D da Silva, Nilza M Scalissi
OBJECTIVE: To compare the body composition among patients with polycystic ovary syndrome (PCOS) and patients without PCOS. METHODS: A cross-sectional study enrolled patients aged 12-39 years, with body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) at least 18.5 but below 25, who attended the Endocrine Gynecology Clinic of Santa Casa de Sao Paulo School of Medical Sciences, Brazil, between January 1, 2014, and July 31, 2015...
November 21, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099629/the-role-of-the-cnr1-gene-in-schizophrenia-a-systematic-review-including-unpublished-data
#19
Eduardo S Gouvêa, Airton F Santos, Vanessa K Ota, Vinicius Mrad, Ary Gadelha, Rodrigo A Bressan, Quirino Cordeiro, Sintia I Belangero
Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28098742/does-transection-of-the-c2-nerve-roots-during-c1-lateral-mass-screw-placement-for-atlantoaxial-fixation-result-in-a-superior-outcome-a-systematic-review-of-the-literature-and-meta-analysis
#20
Jetan H Badhiwala, Farshad Nassiri, Christopher D Witiw, Alireza Mansouri, Saleh A Almenawer, Michael G Fehlings
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To evaluate the clinical and functional outcomes of transection of the C2 roots during C1 lateral mass screw placement for atlantoaxial fixation. SUMMARY OF BACKGROUND DATA: Transection of the C2 nerve roots has been recommended during atlantoaxial fixation to facilitate C1 lateral mass screw placement and possibly reduce post-operative occipital neuralgia, although this practice remains controversial...
January 16, 2017: Spine
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