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https://www.readbyqxmd.com/read/29166732/-application-of-pegylated-recombinant-human-granulocyte-colony-stimulating-factor-to-prevent-chemotherapy-induced-neutropenia-in-patients-with-lymphoma-a-prospective-multicenter-open-label-clinical-trial
#1
H Q Huang, B Bai, Y H Gao, D H Zou, S H Zou, H Tan, Y P Song, Z Y Li, J Jin, W Li, H Su, Y P Gong, M Z Zhong, Y R Shuang, J Zhu, J Q Zhang, Z Cai, Q L Teng, W J Sun, Y Yang, Z J Xia, H L Chen, L M Hua, Y Y Bao, N Wu
Objective: To evaluate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in prophylaxis neutropenia after chemotherapy in patients with lymphoma. Methods: This was a multicenter, single arm, open, phase Ⅳ clinical trial. Included 410 patients with lymphoma received multiple cycles of chemotherapy and PEG-rhG-CSF was administrated as prophylactic. The primary endpoint was the incidence of Ⅲ/Ⅳ grade neutropenia and febrile neutropenia (FN) after each chemotherapy cycle...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166147/preliminary-results-of-lung-cancer-screening-in-a-socioeconomically-disadvantaged-population
#2
Phillip L Guichet, Beringia Y Liu, Bhushan Desai, Zul Surani, Steven Y Cen, Christopher Lee
OBJECTIVE: The objective of our study was to describe the preliminary results of our clinical low-dose CT (LDCT) lung cancer screening program targeting a minority, socioeconomically disadvantaged, high-risk population different from that studied in the National Lung Screening Trial (NLST). MATERIALS AND METHODS: Community partner clinics in an underserved region of south Los Angeles County referred interested candidates to our program. All patients met National Comprehensive Cancer Network eligibility criteria for lung cancer screening...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29164573/role-of-perfusion-ct-in-the-evaluation-of-metastatic-nodal-tumor-response-after-radiochemotherapy-in-head-and-neck-cancer-preliminary-findings
#3
S Ursino, L Faggioni, F Fiorica, D Delishaj, V Seccia, F Pasqualetti, I Desideri, C Colosimo, R Morganti, F Paiar, D Caramella
OBJECTIVE: To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence. PATIENTS AND METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164323/safety-of-intranasal-corticosteroid-sprays-during-pregnancy-an-updated-review
#4
REVIEW
Ahmed H Alhussien, Riyadh A Alhedaithy, Saad A Alsaleh
INTRODUCTION: Rhinitis and rhinosinusitis are commonly encountered in pregnant women. Intranasal corticosteroid (INCS) sprays are generally safe and effective in the treatment of these conditions in the general population. However, the use of some of these INCS sprays during pregnancy is still controversial. OBJECTIVE: To review the current literature about the safety of intranasal corticosteroid sprays during pregnancy. METHODOLOGY: Using different search engines, each type of INCS was reviewed separately (triamcinolone, beclomethasone, budesonide, fluticasone propionate, fluticasone furoate, mometasone, and ciclesonide)...
November 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29162364/is-there-an-association-between-noncontact-anterior-cruciate-ligament-injuries-and-decreased-hip-internal-rotation-or-radiographic-femoroacetabular-impingement-a-systematic-review
#5
REVIEW
Nickolas Boutris, Rory A Byrne, Domenica A Delgado, Timothy E Hewett, Patrick C McCulloch, David M Lintner, Joshua D Harris
PURPOSE: To perform a systematic review to determine if there is (1) an association between decreased hip internal rotation and anterior cruciate ligament (ACL) tear rates; (2) an association between radiographic femoroacetabular impingement (FAI) and ACL tear rates; and (3) biomechanical evidence demonstrating increased strain in the ACL of patients with decreased hip internal rotation. METHODS: A systematic review was performed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
November 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29162130/toward-a-comprehensive-evidence-map-of-overview-of-systematic-review-methods-paper-1-purpose-eligibility-search-and-data-extraction
#6
Carole Lunny, Sue E Brennan, Steve McDonald, Joanne E McKenzie
BACKGROUND: Overviews of systematic reviews attempt to systematically retrieve and summarise the results of multiple systematic reviews. Methods for conducting, interpreting and reporting overviews are in their infancy. To date, there has been no evidence map of the methods used in overviews, thus making it difficult to determine the gaps and priorities for methods research. Our objectives were to develop and populate a comprehensive framework of methods for conducting, interpreting and reporting overviews (stage I) and to create an evidence map by mapping studies that have evaluated overview methods to the framework (stage II)...
November 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29161458/proton-pump-inhibitors-for-functional-dyspepsia
#7
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Ahmed Hassan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161336/efficacy-of-electrical-stimulation-of-the-occipital-nerve-in-intractable-primary-headache-disorders-a-systematic-review-with-meta-analyses
#8
Robert T Cadalso, John Daugherty, Caron Holmes, Saravanan Ram, Reyes Enciso
AIMS: To determine the efficacy of occipital nerve stimulation (ONS) in reducing the intensity, duration, and frequency of medically intractable primary headaches. METHODS: A systematic review was carried out by searching three electronic databases: the Cochrane Library, MEDLINE via PubMed, and Web of Science. Randomized controlled trials (RCTs) and case series were eligible for inclusion. RCTs were assessed for quality of evidence by using the Cochrane Risk of Bias and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tools...
November 21, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29160186/the-impact-of-urban-gardens-on-adequate-and-healthy-food-a-systematic-review
#9
Mariana T Garcia, Silvana M Ribeiro, Ana Claudia Camargo Gonçalves Germani, Cláudia M Bógus
OBJECTIVE: To examine the impacts on food and nutrition-related outcomes resulting from participation in urban gardens, especially on healthy food practices, healthy food access, and healthy food beliefs, knowledge and attitudes. DESIGN: The systematic review identified studies by searching the PubMed, ERIC, LILACS, Web of Science and Embase databases. An assessment of quality and bias risk of the studies was carried out and a narrative summary was produced. SETTING: Studies published as original articles in peer-reviewed scientific journals in English, Spanish or Portuguese between 2005 and 2015 were included...
November 21, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29159958/evaluation-of-a-low-risk-mild-traumatic-brain-injury-and-intracranial-hemorrhage-emergency-department-observation-protocol
#10
Brian J Yun, Pierre Borczuk, Lulu Wang, Stephen Dorner, Benjamin A White, Ali S Raja
OBJECTIVES: Among emergency physicians, there is wide variation in admitting practices for patients who suffered a mild traumatic brain injury (TBI) with an intracranial hemorrhage (ICH). The purpose of this study was to evaluate the effects of implementing a protocol in the emergency department (ED) observation unit for patients with mild TBI and ICH. METHODS: This retrospective cohort study was approved by the Institutional Review Board. Study subjects were patients ≥18 years of age with an International Classification of Diseases (ICD) code corresponding to a traumatic IC, and admitted to an ED observation unit (EDOU) of an urban, academic level 1 trauma center between February 1, 2015 and January 31, 2017...
November 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29159815/effectiveness-of-interventions-for-breast-cancer-screening-in-african-american-women-a-meta-analysis
#11
Valire Carr Copeland, Yoo Jung Kim, Shaun M Eack
OBJECTIVE: The purpose of this study was to report the results of a meta-analysis conducted on the effects of clinical trials in breast cancer screening for African American women between 1997 and 2017. DATA SOURCES: Articles published in English and in the United States, between January 1997 and March 2017, were eligible for inclusion if they (1) conducted psychosocial, behavioral, or educational interventions designed to increase screening mammography rates in predominantly African American women of all ages; (2) utilized a randomized, controlled trial (RCT) design; and (3) reported quantitative screening rates following the intervention...
November 21, 2017: Health Services Research
https://www.readbyqxmd.com/read/29158898/an-evaluation-of-the-predictive-validity-of-the-urica-and-ansocq-scales-for-weight-gain-in-adults-with-an-in-an-outpatient-eating-disorders-program-a-prospective-cohort-study
#12
Jessica Green, Andrea Philipou, David Castle, Leonardo Cistullo, Richard Newton
Background: The Transtheoretical Model (TTM) which focuses on stage of change has been the main conceptual model used in understanding the lack of motivation to change in patients with Anorexia Nervosa (AN). Whilst there is evidence to support the prognostic value of the TTM in AN, this evidence base sufferers from limitations including limited studies in adults and none in outpatient populations. The primary aim of this study was to clarify whether readiness to change, as measured by the University Rhode Island Change Assessment Scale (URICA) and the Anorexia Nervosa Stages of Change Questionnaire (ANSOCQ) could predict weight gain in adults with AN following treatment in an outpatient setting...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#13
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158102/human-papillomavirus-types-from-infection-to-cancer-in-the-anus-according-to-sex-and-hiv-status-a-systematic-review-and-meta-analysis
#14
Chunqing Lin, Silvia Franceschi, Gary M Clifford
BACKGROUND: Data on carcinogenicity of human papillomavirus (HPV) types in the anus are needed to inform anal cancer prevention through vaccination and screening. This is particularly the case for people infected with HIV, who are at an increased risk of anal cancer. METHODS: We did a systematic review of studies published from January, 1986, to July, 2017, in MEDLINE, Embase, and the Cochrane Library on anal HPV infection, without any language restrictions. Eligible studies reported type-specific HPV prevalence by strata of cytopathological or histopathological anal diagnosis, sex, and HIV status...
November 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29157592/the-effects-of-continuous-positive-airway-pressure-therapy-on-troponin-t-and-n-terminal-pro-b-type-natriuretic-peptide-in-patients-with-obstructive-sleep-apnoea-a-randomised-controlled-trial
#15
Ya-Shu Chang, Brendon J Yee, Camilla M Hoyos, Keith K Wong, David R Sullivan, Ronald R Grunstein, Craig L Phillips
INTRODUCTION: Untreated obstructive sleep apnoea (OSA) is associated with increased risk of coronary artery disease (CAD) and heart failure. High-sensitivity cardiac troponin (hs Trop-T) and B-type natriuretic peptide (NT-pro-BNP) are sensitive biomarkers for myocardial injury and heart failure respectively. No randomised controlled trials have examined the treatment effect of continuous positive airway pressure (CPAP) in patients with OSA on these biomarkers. METHOD: Patients >21 years old with apnoea-hypopnoea index (AHI) ≥25/h by overnight polysomnography were recruited...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29157510/euthanasia-requests-in-a-canadian-psychiatric-emergency-room-a-case-series-part-1-of-the-mcgill-university-euthanasia-in-psychiatry-case-series
#16
David Benrimoh, Antoine Perreault, Frederique Van Den Eynde
Euthanasia was decriminalized in Quebec in December 2015, and Canada-wide in June 2016. Both the Provincial and Federal legislation have limited the right to medical assistance in dying (MAID) to end-of-life cases; which makes MAID inaccessible to most patients solely suffering from psychiatric illness. While some end-stage anorexia nervosa or elderly patients may meet the end-of-life criterion because of their medical comorbidities or their age (Kelly et al., 2003), repeated suicide attempts or psychotic disorganization would not qualify since they would not be seen as elements of an illness leading to a foreseeable "natural death" (Canada, 2016)...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29157302/prevalence-of-lactose-intolerance-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome-data-from-a-tertiary-center-in-southern-china
#17
Lishou Xiong, Yilin Wang, Xiaorong Gong, Minhu Chen
BACKGROUND: Symptoms associated with lactose intolerance (LI) and diarrhea-predominant irritable bowel syndrome (IBS-D) are almost the same. These disease entities are difficult to differentiate clinically. In practice, differential diagnosis depends on self-reported patient milk intolerance. However, there is limited data on the prevalence of LI in China. The aim of this study was to investigate the prevalence of LI in IBS-D patients and asymptomatic healthy controls. METHODS: Lactose malabsorption (LM) was diagnosed by a lactose hydrogen breath test (HBT) and was defined by peak breath H2 excretion over the baseline level of ≥ 20 ppm...
November 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29156896/proutine-a-feasibility-study-assessing-surveillance-of-electronic-patient-reported-outcomes-and-adherence-via-smartphone-app-in-advanced-cancer
#18
Gesine Benze, Friedemann Nauck, Bernd Alt-Epping, Giuseppe Gianni, Thomas Bauknecht, Johannes Ettl, Anna Munte, Luisa Kretzschmar, Jan Gaertner
BACKGROUND: In advanced cancer, quality of life (QoL) is a major treatment goal. In order to achieve this, the identification of suffering by screening for patient-reported-outcomes (PROs, i.e., symptoms) is of utmost importance. The use of paper-pencil questionnaires is associated with significant shortcomings due to missing data, recall bias and transcription errors. Other than that, the electronic recording of PROs by mobile Health (mHealth) offers a number of advantages. The aim of this study was to test whether the routine assessment of PROs via a newly developed smartphone application (MeQoL®) is feasible...
October 26, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156647/effects-of-nutritional-interventions-during-pregnancy-on-infant-and-child-cognitive-outcomes-a-systematic-review-and-meta-analysis
#19
REVIEW
Rachael M Taylor, Shanna M Fealy, Alessandra Bisquera, Roger Smith, Clare E Collins, Tiffany-Jane Evans, Alexis J Hure
BACKGROUND: Epidemiological studies have demonstrated that folate, iodine and iron intake during pregnancy impacts on foetal brain development and cognitive function. However, in human studies, the relationship with other dietary nutrients is less clear. OBJECTIVE: This systematic review aims to critically appraise the current literature and meta-analyses results from nutritional interventions during pregnancy that aimed to optimise infant and child cognitive outcomes...
November 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29156092/gingival-cyst-of-the-adult-lateral-periodontal-cyst-and-botryoid-odontogenic-cyst-an-updated-systematic-review
#20
REVIEW
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
OBJECTIVE: To integrate the available data published on gingival cyst of the adult (GCA), lateral periodontal cyst (LPC) and botryoid odontogenic cyst (BOC) into a comprehensive analysis of their clinical/radiologic features. METHODS: An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. RESULTS: 146 publications (157 GCAs, 213 LPCs, 96 BOCs) were included...
November 20, 2017: Oral Diseases
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