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https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#1
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/27998040/sleep-apnoea-in-heart-failure-to-treat-or-not-to-treat
#2
REVIEW
Matthew T Naughton, Kirk Kee
Heart failure (HF) and sleep apnoea are common disorders which frequently coexist. Two main types of apnoea occur: one is obstructive which, through recurring episodes of snoring, hypoxaemia, large negative intra-thoracic pressures and arousals from sleep leading to downstream inflammatory and autonomic nervous system changes, is thought to be a causative factor to the development of systemic hypertension and HF. The other type of apnoea, Cheyne-Stokes respiration with central sleep apnoea (CSR-CSA), is characterized by an oscillatory pattern of ventilation with a prevailing hyperventilation-induced hypocapnia, often in the absence of significant hypoxaemia and snoring, and is thought to be a consequence of advanced HF-related low cardiac output, high sympathetic nervous system activation and pulmonary congestion...
December 20, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27938912/improvements-of-central-respiratory-events-cheyne-stokes-respiration-and-oxygenation-in-patients-hospitalized-for-acute-decompensated-heart-failure
#3
Kristina Basic, Henrik Fox, Jens Spießhöfer, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg
BACKGROUND: Sleep-disordered breathing (SDB), and Cheyne-Stokes respiration (CSR) in particular, are associated with reduced survival in patients with acute decompensated heart failure (ADHF). CSR cycle length (CL) has been shown to mirror heart failure severity and therefore may be a predictor of outcome. However, studies characterizing CSR in ADHF are rare and no study has investigated changes in CSR from admission to discharge in ADHF patients. METHODS: Consecutive patients admitted to our Academic Medical Center with ADHF were eligible...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27896626/cheyne-stokes-respiration-during-wakefulness-in-patients-with-chronic-heart-failure
#4
Wolfram Grimm, Karl Kesper, Werner Cassel, Nina Timmesfeld, Olaf Hildebrandt, Ulrich Koehler
PURPOSE: Cheyne-Stokes respiration (CSR) during sleep has been studied extensively in patients with chronic heart failure (CHF). Prevalence and prognostic significance of CSR during wakefulness in CHF, however, are largely unknown. METHODS: CSR during wakefulness with an apnea-hypopnea cut-off ≥5/h and moderate to severe CSR with an apnea-hypopnea cutoff ≥15/h were analyzed using polysomnographic recordings in 267 patients with stable CHF with reduced left ventricular (LV) ejection fraction at our institution...
November 28, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27854123/a-retrospective-analysis-of-cardiovascular-outcomes-in-patients-treated-with-asv
#5
Arild Hetland, Kristina H Haugaa, Maria Vistnes, Kristian Hovde Liland, Margareth Olseng, Morten B Jacobsen, Thor Edvardsen
OBJECTIVES: The effect of long-term adaptive servo-ventilation (ASV) on cardiovascular mortality and admission rates in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) has not been much studied. The aim of this study was primarily to investigate whether ASV therapy significantly reduced these parameters. DESIGN: We included 75 CHF patients on optimal medication and CSR ≥25% of sleeping time, in New York Heart Association (NYHA) classes II-IV and left ventricular ejection fraction (LVEF) ≤ 45%...
December 7, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27844220/respiratory-optimized-data-selection-for-more-resilient-self-navigated-whole-heart-coronary-mr-angiography
#6
Jerome Chaptinel, Davide Piccini, Gabriele Bonanno, Simone Coppo, Pierre Monney, Matthias Stuber, Juerg Schwitter
OBJECTIVES: Our objective was to test a data-exclusion strategy for respiratory motion suppression by retrospectively eliminating data acquired at extreme respiratory positions for improved coronary vessel sharpness (VS) of 1-D self-navigated 3-D radial whole-heart coronary angiography acquisitions. MATERIALS AND METHODS: 3-D radial self-navigated acquisitions were performed on a 1.5T scanner in volunteers during free-breathing (n = 8), in coached volunteers (n = 13) who were asked to breathe in a controlled manner to mimic cardiovascular patients presenting with Cheyne-Stokes breathing, and in free-breathing patients (n = 20)...
November 14, 2016: Magma
https://www.readbyqxmd.com/read/27797160/pathogenesis-of-central-and-complex-sleep-apnoea
#7
REVIEW
Jeremy E Orr, Atul Malhotra, Scott A Sands
Central sleep apnoea (CSA) - the temporary absence or diminution of ventilatory effort during sleep - is seen in a variety of forms including periodic breathing in infancy and healthy adults at altitude and Cheyne-Stokes respiration in heart failure. In most circumstances, the cyclic absence of effort is paradoxically a consequence of hypersensitive ventilatory chemoreflex responses to oppose changes in airflow, that is elevated loop gain, leading to overshoot/undershoot ventilatory oscillations. Considerable evidence illustrates overlap between CSA and obstructive sleep apnoea (OSA), including elevated loop gain in patients with OSA and the presence of pharyngeal narrowing during central apnoeas...
January 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27707449/ventilatory-cycle-measurements-and-loop-gain-in-central-apnea-in-mining-drivers-exposed-to-intermittent-altitude
#8
Jorge Rey de Castro, Alicia Liendo, T Oswaldo Ortiz, Edmundo Rosales-Mayor, César Liendo
OBJECTIVES: By measuring the apnea length, ventilatory phase, respiratory cycle length, and loop gain, we can further characterize the central apneas of high altitude (CAHA). METHODS: Sixty-three drivers of all-terrain vehicles, working in a Peruvian mine located at 2020 meters above sea level (MASL), were evaluated. A respiratory polygraph was performed in the first night they slept at high altitude. None of the subjects were exposed to oxygen during the test or acetazolamide in the preceding days of the test...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27602681/cheyne-stokes-respiration-chemoreflex-and-ticagrelor-related-dyspnea
#9
LETTER
Alberto Giannoni, Michele Emdin, Claudio Passino
No abstract text is available yet for this article.
September 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27592224/mechanisms-underlying-increased-mortality-risk-in-patients-with-heart-failure-and-reduced-ejection-fraction-randomly-assigned-to-adaptive-servoventilation-in-the-serve-hf-study-results-of-a-secondary-multistate-modelling-analysis
#10
Christine Eulenburg, Karl Wegscheider, Holger Woehrle, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita K Simonds, Virend K Somers, Faiez Zannad, Helmut Teschler, Martin R Cowie
BACKGROUND: A large randomised treatment trial (SERVE-HF) showed that treatment of central sleep apnoea with adaptive servoventilation in patients with heart failure and reduced ejection fraction (HFREF) increased mortality, although the analysis of the composite primary endpoint (time to first event of death from any cause, life-saving cardiovascular intervention, or unplanned hospital admission for worsening heart failure) was neutral. This secondary multistate modelling analysis of SERVE-HF data investigated associations between adaptive servoventilation and individual components of the primary endpoint to try to better understand the mechanisms underlying the observed increased mortality...
August 31, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27587554/control-theory-prediction-of-resolved-cheyne-stokes-respiration-in-heart-failure
#11
Scott A Sands, Bradley A Edwards, Kirk Kee, Christopher Stuart-Andrews, Elizabeth M Skuza, Teanau Roebuck, Anthony Turton, Garun S Hamilton, Matthew T Naughton, Philip J Berger
Cheyne-Stokes respiration (CSR) foretells deleterious outcomes in patients with heart failure. Currently, the size of therapeutic intervention is not guided by the patient's underlying pathophysiology. In theory, the intervention needed to resolve CSR, as a control system instability (loop gain >1), can be predicted knowing the baseline loop gain and how much it falls with therapy.In 12 patients with heart failure, we administered an inspiratory carbon dioxide fraction of 1-3% during CSR (n=95 interventions) as a means to reduce loop gain...
September 1, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27559818/resonance-as-the-mechanism-of-daytime-periodic-breathing-in-patients-with-heart-failure
#12
Scott A Sands, Yoseph Mebrate, Bradley A Edwards, Shamim Nemati, Charlotte H Manisty, Akshay S Desai, Andrew Wellman, Keith Willson, Darrel P Francis, James P Butler, Atul Malhotra
RATIONALE: In patients with chronic heart failure, daytime oscillatory breathing at rest is associated with a high risk of mortality. Experimental evidence, including exaggerated ventilatory responses to CO2 and prolonged circulation time, implicates the ventilatory control system and suggests feedback instability (loop gain > 1) is responsible. However, daytime oscillatory patterns often appear remarkably irregular versus classic instability (Cheyne-Stokes respiration), suggesting our mechanistic understanding is limited...
January 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27558771/association-of-central-sleep-apnea-with-impaired-heart-structure-and-cardiovascular-hemodynamics-in-patients-with-chronic-heart-failure
#13
Anna Kazimierczak, Paweł Krzesiński, Grzegorz Gielerak, Beata Uziębło-Życzkowska, Paweł Smurzyński, Robert Ryczek, Andrzej Cwetsch, Andrzej Skrobowski
BACKGROUND Advanced heart failure (HF) is commonly accompanied by central sleep apnea (CSA) with Cheyne-Stokes respiration (CSR). The aim of this study was to evaluate the relationship between CSA/CSR and other clinical features of HF, with particular emphasis on cardiovascular hemodynamics. MATERIAL AND METHODS In 161 stable HF patients with left ventricular ejection fraction (LVEF) ≤45% (NYHA class I-III; mean LVEF 32.8%) the clinical evaluation included: LVEF; left and right ventricular end-diastolic diameter (LVDd, RVDd); ratio of early transmitral flow velocity to early diastolic septal mitral annulus velocity (E/e') assessed by echocardiography; stroke index (SI); heart rate (HR); cardiac index (CI); and systemic vascular resistance index (SVRI) assessed by impedance cardiography (ICG)...
August 25, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27441470/association-between-polymorphisms-of-the-hspb7-gene-and-cheyne-stokes-respiration-with-central-sleep-apnea-in-patients-with-dilated-cardiomyopathy-and-congestive-heart-failure
#14
Mengmei Wang, Hao Ding, Jing Kang, Ke Hu, Wen Lu, Xiufang Zhou, Lifang Xu
BACKGROUND: CSR-CSA is frequent in patients with CHF. Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background, yet one of the leading etiological causes of CHF. Studies have showed that the HSPB7 gene is associated with DCM. OBJECTIVES: We aimed to explore the prevalence of polymorphisms of the HSPB7 gene in the Chinese Han population with CSR-CSA and CHF caused by DCM. METHODS: A total of 503 unrelated subjects of the Chinese Han population, including 283 CHF patients caused by DCM and 220 healthy controls, were involved in the study...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27387522/adaptive-servo-ventilation-therapy-improves-cardiac-sympathetic-nerve-activity-cardiac-function-exercise-capacity-and-symptom-in-patients-with-chronic-heart-failure-and-cheyne-stokes-respiration
#15
Takuji Toyama, Hiroshi Hoshizaki, Shu Kasama, Yusuke Miyaishi, Hakuken Kan, Eiji Yamashita, Ren Kawaguti, Hitoshi Adachi, Shigeru Ohsima
PURPOSE: Adaptive servo-ventilation (ASV) therapy has been reported to be effective for improving central sleep apnea (CSA) and chronic heart failure (CHF). The purpose of this study was to clarify whether ASV is effective for CSA, cardiac sympathetic nerve activity (CSNA), cardiac symptoms/function, and exercise capacity in CHF patients with CSA and Cheyne-Stokes respiration (CSR-CSA). METHODS: In this study, 31 CHF patients with CSR-CSA and a left ventricular ejection fraction (LVEF) ≤ 40% were randomized into an ASV group and a conservative therapy (non-ASV) group for 6 month...
July 7, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27273784/quality-of-life-improves-in-patients-with-chronic-heart-failure-and-cheyne-stokes-respiration-treated-with-adaptive-servo-ventilation-in-a-nurse-led-heart-failure-clinic
#16
Margareth W Olseng, Brita F Olsen, Arild Hetland, May S Fagermoen, Morten Jacobsen
AIMS AND OBJECTIVES: The aim of this study was to investigate if quality of life improved in chronic heart failure patients with Cheyne-Stokes respiration treated with adaptive servo-ventilation in nurse-led heart failure clinic. BACKGROUND: Cheyne-Stokes respiration is associated with decreased quality of life in patients with chronic heart failure. Adaptive servo-ventilation is introduced to treat this sleep-disordered breathing. DESIGN: Randomized, controlled design...
June 6, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27234869/current-and-future-developments-in-the-field-of-central-sleep-apnoea
#17
REVIEW
Tarek Bekfani, William T Abraham
Central sleep apnoea (CSA) occurs in ∼30-50% of patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) and in as much as in 18-30% of patients with preserved LVEF. In HF patients, it is characterized by periodic breathing also known as the Cheyne-Stokes respiration followed by pauses of breathing. Central sleep apnoea remains often unrecognized due to its chronic and insidious incidences. Patients may report excessive daytime somnolence, poor sleep quality, nocturnal angina, recurrent arrhythmias, refractory HF symptoms, or demonstrate abnormal respiratory pattern or apnoeas...
August 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27166235/prevalence-and-characteristics-of-central-compared-to-obstructive-sleep-apnea-analyses-from-the-sleep-heart-health-study-cohort
#18
Lucas M Donovan, Vishesh K Kapur
STUDY OBJECTIVES: Determine the prevalence of central sleep apnea (CSA) in a large community-based cohort using current definitions and contrast the clinical characteristics of subjects with CSA to those with obstructive sleep apnea (OSA) and no sleep apnea. METHODS: A cross sectional analysis of baseline data from 5,804 participants of the Sleep Heart Health study was performed. Subjects meeting contemporary diagnostic criteria for CSA and Cheyne Stokes respiration (CSR) were compared to those without sleep apnea and those with OSA...
July 1, 2016: Sleep
https://www.readbyqxmd.com/read/27127671/impact-of-heart-transplantation-on-cheyne-stokes-respiration-in-a-child
#19
Suhail Al-Saleh, Paul F Kantor, Indra Narang
Sleep disordered breathing is well described in adults with heart failure but not in pediatric population. We describe a 13-year-old Caucasian male with severe heart failure related to dilated cardiomyopathy who demonstrated polysomnographic features of Cheyne-Stokes respiration, which completely resolved following cardiac transplantation. Cheyne-Stokes respiration in children with advanced heart failure and its resolution after heart transplant can be observed similar to adults.
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/26995256/the-effect-of-adaptive-servo-ventilation-asv-on-objective-and-subjective-outcomes-in-cheyne-stokes-respiration-csr-with-central-sleep-apnea-csa-in-heart-failure-hf-a-systematic-review
#20
REVIEW
Hyunju Yang, Amy M Sawyer
To summarize the current evidence for adaptive servo ventilation (ASV) in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF) and advance a research agenda and clinical considerations for ASV-treated CSR-CSA in HF. CSR-CSA in HF is associated with higher overall mortality, worse outcomes and lower quality of life (QOL) than HF without CSR-CSA. Five databases were searched using key words (n = 234). Randomized controlled trials assessed objective sleep quality, cardiac, and self-reported outcomes in adults (≥18 years) with HF (n = 10)...
May 2016: Heart & Lung: the Journal of Critical Care
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