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https://www.readbyqxmd.com/read/29673669/rupture-of-the-scarred-and-unscarred-gravid-uterus-outcomes-and-risk-factors-analysis
#1
Shu-Han You, Yao-Lung Chang, Chih-Feng Yen
OBJECTIVE: To study the maternal and fetal outcomes and assess the risk factors in patients with rupture at the lower-segment or non-lower-segment scarred, or unscarred gravid uterus. MATERIALS AND METHODS: Gravid patients with uterine rupture were retrospectively collected in Chang-Gung Memorial Hospital from November 2004 to July 2017. The rupture timing and location in association with maternal and fetal outcomes were collected as well as the possible risk factors including surgical history and interval prior to conception were analyzed...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29668969/liquid-based-cytology-versus-conventional-cytology-for-detection-of-uterine-cervical-lesions-a-prospective-observational-study
#2
Hiroshi Nishio, Takashi Iwata, Hidetaka Nomura, Tohru Morisada, Nobuhiro Takeshima, Hirokuni Takano, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki
Objective: Liquid-based cytology (LBC) and conventional cytology (CS) are routine diagnostic techniques in cervical cytology, but few studies have compared their diagnostic performances with each other and with histologic diagnosis. This study aimed to compare the diagnostic performances of these techniques in subjects with abnormal cervical cytology of atypical cells of undetermined significance (ASC-US) or worse. Methods: A total of 312 patients diagnosed with ASC-US or worse were enrolled in this prospective study in Japan from 2013 to 2014...
April 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29666002/clinical-pathologic-cytogenetic-and-molecular-profiling-in-self-identified-black-women-with-uterine-leiomyomata
#3
Mark A Hayden, Zehra Ordulu, C Scott Gallagher, Bradley J Quade, Raymond M Anchan, Nia Robinson Middleton, Serene S Srouji, Elizabeth A Stewart, Cynthia C Morton
Black women are disproportionately affected by uterine leiomyomata (UL), or fibroids, compared to other racial groups, having a greater lifetime risk of developing UL and an earlier age of diagnosis. In order to elucidate molecular and genetic mechanisms responsible for the increased prevalence and morbidity associated with UL in black women, clinical, pathologic, cytogenetic, and select molecular profiling (MED12 mutation analysis) of 75 self-reported black women undergoing surgical treatment for UL was performed...
April 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29664552/importance-of-polymorphic-variants-of-tumour-necrosis-factor-%C3%AE-gene-in-the-etiology-of-intrauterine-growth-restriction
#4
Agnieszka Kaluba-Skotarczak, Justyna Magiełda, Anna Romała, Grażyna Kurzawińska, Magdalena Barlik, Krzysztof Drews, Marcin Ożarowski, Tomasz Łoziński, Agnieszka Seremak-Mrozikiewicz
OBJECTIVES: Intrauterine growth restriction (IUGR) is one of the main global causes of increased perinatal mortality and fetal and neonatal morbidity. It remains a key challenge for modern perinatal medicine. Negative effects of IUGR are manifested not only in the perinatal period but also at the later stages of life. Proinflammatory cytokines and their polymorphisms are hypothesized to play an important role in IUGR pathomechanisms. The aim of the study was to determine the role of selected polymorphisms (-238G >A, -308G >A and -376G >A) of tumor necrosis factor alpha (TNF-α) in the etiology of intrauterine growth restriction...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29662708/emergency-peripartum-hysterectomy-in-the-dubai-health-system-a-fifteen-year-experience
#5
Muna Abdulrazzaq Tahlak, Mahera Abdulrahman, Nawal Mahmood Hubaishi, Mushtaq Omar, Fatima Cherifi, Shazia Magray, Frederick Robert Carrick
Objective: To determine the incidence, demographic data, risk factors, indications, outcome and complications of emergency peripartum hysterectomy (EPH) performed in two major tertiary care hospitals in Dubai, and to compare the results with the literature. Materials and Methods: The records of all women who underwent EPH from January 2000 to December 2015 in two major tertiary care hospitals in Dubai were accessed and reviewed. Maternal characteristics, hysterectomy indications, outcomes, and postoperative complications were recorded using descriptive statistics to describe the cohort...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29659871/rare-variants-in-the-gene-alpl-that-cause-hypophosphatasia-are-strongly-associated-with-ovarian-and-uterine-disorders
#6
Kathryn M Dahir, Daniel R Tilden, Jeremy L Warner, Lisa Bastarache, Derek K Smith, Aliya Gifford, Andrea H Ramirez, Jill Simmons, Margo M Black, John H Newman, Josh C Denny
Background: Mutations in ALPL, which encodes tissue-nonspecific isozyme alkaline phosphatase (TNSALP), cause hypophosphatasia (HPP). HPP is suspected by a low serum alkaline phosphatase (AlkP). We hypothesized that some patients with bone or dental disease have undiagnosed HPP caused by ALPL variants. Our objective was to discover the prevalence of these gene variants in the Vanderbilt DNA biobank (BioVU) and to assess phenotypic associations. Methods: We identified subjects in BioVU, a repository of DNA, that had at least one of three known rare HPP disease-causing variants in ALPL: rs199669988, rs121918007, rs121918002...
April 6, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29658437/decreased-expression-of-hoxa10-may-activate-the-autophagic-process-in-ovarian-endometriosis
#7
Jingjie Zheng, Xishao Luo, Jiaping Bao, Xiaowang Huang, Yi Jin, Lin Chen, Feiyun Zheng
Autophagy is a survival process that maintains homeostasis in all eukaryotic cells. Recent studies show an abnormal autophagic activity in endometriosis, but the role of autophagy is controversial. Homeobox A10 (HOXA10) is a transcription factor necessary for embryonic and adult uterine development, and studies indicate that its expression decreases in endometriosis. Homeobox A10 may negatively regulate autophagy in endometriosis. To test this hypothesis, we measured the expression levels of autophagic biomarkers (beclin-1 and LC3-II) and HOXA10 proteins by Western blotting and messenger RNA (mRNA) by quantitative real-time polymerase chain reaction...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29657247/protective-effect-of-taohong-siwu-decoction-on-abnormal-uterine-bleeding-induced-by-incomplete-medical-abortion-in-rats-during-early-pregnancy
#8
Yanyan Zhang, Jichen Wang, Chijing Zuo, Weidong Chen, Qian Zhu, Dongdong Guo, Huanru Wu, Huizhuo Wang, Daiyin Peng, Lan Han
Abnormal uterine bleeding (AUB) induced by incomplete abortion is a common gynecological disease. Taohong Siwu decoction (TSD) is a traditional Chinese medicine (TCM) formula, which has been developed to treat AUB for hundreds of years. In this study, rats had incomplete abortion induced in early pregnancy using mifepristone and misoprostol. The duration and quantity of uterine bleeding were recorded and measured. The pathologic histologic grade was evaluated by hematoxylin-eosin staining (HE). Estradiol (E2 ) and progesterone (P) levels were measured by enzyme linked immunosorbent assays (ELISA)...
April 14, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29643846/lilrb4-decrease-on-udcs-exacerbate-abnormal-pregnancy-outcomes-following-toxoplasma-gondii-infection
#9
Shaowei Zhan, Jing Zheng, Haixia Zhang, Mingdong Zhao, Xianbing Liu, Yuzhu Jiang, Chunyan Yang, Liqin Ren, Zhiqiang Liu, Xuemei Hu
Toxoplasma gondii ( T. gondii ) infection in early pregnancy can result in miscarriage, dead fetus, and other abnormalities. The LILRB4 is a central inhibitory receptor in uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface. In this study, T. gondii -infected human primary uDCs and T. gondii -infected LILRB4-/- pregnant mice were utilized. The immune mechanisms underlying the role of LILRB4 on uDCs were explored in the development of abnormal pregnancy outcomes following T...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29643616/labor-analgesia-in-parturients-of-fetal-growth-restriction-having-raised-umbilical-doppler-vascular-indices
#10
Sukhen Samanta, Kajal Jain, Neerja Bhardwaj, Vanita Jain, Preet Mohinder Singh, Sujay Samanta, Veenu Singla, Rini Saha
Background and Aims: Fetuses with abnormal umbilical blood flow are at a higher risk of adverse perinatal outcome than those with normal flow. Epidural analgesia (EA) has shown to decrease villous vascular resistance in preeclamptic women during labor. The present study evaluates the effects of epidural ropivacaine and intramuscular (IM) tramadol on Doppler blood flow in parturients with fetal growth restriction and raised umbilical artery (UmA) blood flow. Material and Methods: In this prospective nonrandomized comparative study, 36 term parturients with sonographic evidence of UmA systolic-diastolic (S-D) ratio ≥3 were enrolled...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29628726/abnormal-uterine-bleeding-evaluation-by-endometrial-aspiration
#11
Pratibha Singh
Endometrial evaluation is generally indicated in cases presenting with abnormal uterine bleeding (AUB), especially in women more than 35 years of age. AUB encompasses a variety of presentation, for example, heavy menstrual bleeding, frequent bleeding, irregular vaginal bleeding, postcoital and postmenopausal bleeding to name a few. Many methods are used for the evaluation of such cases, with most common being sonography and endometrial biopsy with very few cases requiring more invasive approach like hysteroscopy...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29611773/effect-of-surgical-adhesive-on-the-uterus-of-rabbits-following-occlusion
#12
Anran Xu, Tianyu Hao, Xiaoqing Wei, Chuanfen Li, Lihua Niu, Xiaohui Deng
Purpose/Aim of the Study: The present study investigated the effect of surgical adhesives on the uterus of rabbits and the histomorphology alterations following occlusion, to improve the clinical treatment of abnormal fallopian tube with surgical adhesives for in vitro fertilization and embryo transfer (IVF-ET). MATERIALS AND METHODS: The experimental rabbits received laparotomy and occlusion of the uterus by surgical adhesive adjacent to the two fallopian tubes, while the control rabbits only received laparotomy...
April 3, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29611018/the-who-what-why-and-when-of-gynaecological-referrals-for-refugee-women
#13
Sarah L Silverberg, Lacey Harding, Rachel F Spitzer, Meb Rashid
Refugees have health needs relating to unstable living situations and poor access to care. We examined the nature of health problems requiring gynaecological referrals for refugee women in Toronto. A retrospective cohort design was used to examine gynaecologic referrals of women at a refugee clinic between December, 2011 and June, 2016. The primary outcome measure was the indications for gynaecological referral. 125 out of 1040 women received a gynaecologic referral for 131 unique concerns. The most common referrals were for abnormal uterine bleeding and cervical dysplasia...
April 2, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29609956/the-arcuate-uterus-is-there-an-impact-on-in-vitro-fertilization-outcomes-after-euploid-embryo-transfer
#14
Eric S Surrey, Mandy Katz-Jaffe, Rebecca L Surrey, Amy Snyder Small, Robert L Gustofson, William B Schoolcraft
OBJECTIVE: To study the impact of the arcuate uterus on euploid blastocyst-stage embryo transfer outcomes after comprehensive chromosomal screening (CCS). DESIGN: Controlled retrospective trial. SETTING: Tertiary care assisted reproduction technology (ART) center. PATIENT(S): Consecutive patients undergoing in vitro fertilization and euploid embryo transfer after CCS during 2014. INTERVENTION(S): Ultrasound examinations and office hysteroscopy; array comparative genomic hybridization to perform CCS after a trophectoderm biopsy...
March 30, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29607557/maternal-hemodynamics-fetal-biometry-and-dopplers-in-pregnancies-followed-up-for-suspected-fetal-growth-restriction
#15
Llinos A Roberts, Hua Zen Ling, Liona Poon, Kypros H Nicolaides, Nikos A Kametas
OBJECTIVES: To assess whether in a cohort of patients with small for gestational age (SGA) foetuses with estimated fetal weight ≤10th percentile, maternal hemodynamics, fetal biometry and Dopplers at presentation, can predict the subsequent development of abnormal fetal Dopplers or delivery with birthweight <3rd percentile. METHODS: The study population comprised of 86 singleton pregnancies with SGA fetuses presenting at a median gestational age of 32 (range 26-35) weeks...
April 1, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29607236/a-case-of-primary-uterina-lymphoma-presenting-with-bleeding-pelvic-pain-and-dysmenorrhea
#16
Lilian Yukari Miura, Miriam Anyury Daquin Maure, Monica Tessmann Zomer, Reitan Ribeiro, Teresa Cristina Santos Cavalcanti, William Kondo
Primary non-Hodgkin's lymphoma (NHL) can arise from lymphatic cells located in solid organs (extranodal) and it accounts for 25 to 35% of all NHL. Primary lymphoma on the female genital tract (PLFGT) is a rare disease, comprising 0.2 to 1.1% of all extranodal lymphomas in the female population. In this paper, the authors report an extremely rare case of a 48-year-old woman who exhibited an abnormal uterine bleeding, pelvic pain, and dysmenorrhea history. The transvaginal ultrasound showed an anteverted uterus measuring 153 cm3 in volume, with intramural leiomyomas...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29606892/management-of-abnormal-uterine-bleeding-focus-on-ambulatory-hysteroscopy
#17
REVIEW
Shilpa Kolhe
The rapid evolution in ambulatory hysteroscopy (AH) has transformed the approach to diagnose and manage abnormal uterine bleeding (AUB). The medical management in primary care remains the mainstay for initial treatment of this common presentation; however, many women are referred to secondary care for further evaluation. To confirm the diagnosis of suspected intrauterine pathology, the traditional diagnostic tool of day case hysteroscopy and dilatation and curettage in a hospital setting under general anesthesia is now no longer required...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29604475/robotic-assisted-laparoscopic-cervicovaginal-myomectomy
#18
Pouya Javadian, Alexander Juusela, Farr Nezhat
STUDY OBJECTIVE: To illustrate a robotic assisted laparoscopic resection for the cervicovaginal myomectomy. DESIGN: Step-wise instruction using video. Case report (Canadian Task Force classification III). SETTING: A tertiary referral center in New York, NY, USA. A 39-year-old woman G0, (body mass index of 23.0 kg/m2 ) with known cervicovaginal fibroid which in the past underwent uterine artery embolization, presented with recurrence of her severe abnormal vaginal bleeding...
March 28, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29604099/evaluation-of-complete-blood-count-parameters-to-predict-endometrial-cancer
#19
Cigdem Yayla Abide, Evrim Bostanci Ergen, Ebru Cogendez, Cetin Kilicci, Faik Uzun, Enis Ozkaya, Ates Karateke
BACKGROUND: Complete blood count parameters have been introduced to be diagnostic biomarkers for many cancer-related diseases associated with inflammatory process. The aim of our study was to detect whether there is any relationship between benign or malignant endometrial pathologies and complete blood count parameters. METHODS: Four hundred and sixteen patients with a complaint of abnormal uterine bleeding who admitted to Zeynep Kamil Women and Children's Health Training and Research hospital between 2013 and 2016 and undergoing endometrial biopsy were included in the study...
March 31, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29593995/late-onset-endometrial-ablation-failure
#20
REVIEW
Morris Wortman
Endometrial ablation, first reported in the 19th century, has gained wide acceptance in the gynecologic community as an important tool for the management of abnormal uterine bleeding when medical management has been unsuccessful or contraindicated. The introduction of global endometrial ablation (GEA) devices beginning in 1997 has provided unsurpassed safety addressing many of the concerns associated with their resectoscopic predecessors. As of this writing the GEA market has surpassed a half-million devices in the United States per annum and has an expected compound annual growth rate (CAGR) projected to be 5...
July 2017: Case Reports in Women's Health
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