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https://www.readbyqxmd.com/read/28822072/cellular-and-molecular-oxidative-stress-related-effects-in-uterine-myometrial-and-trophoblast-decidual-tissues-after-perigestational-alcohol-intake-up-to-early-mouse-organogenesis
#1
Tamara Anahí Coll, Gabriela Chaufan, Leticia Gabriela Pérez-Tito, Martín Ricardo Ventureira, María Del Carmen Ríos de Molina, Elisa Cebral
The placenta plays a major role in embryo-fetal defects and intrauterine growth retardation after maternal alcohol consumption. Our aims were to determine the oxidative status and cellular and molecular oxidative stress effects on uterine myometrium and trophoblast-decidual tissue following perigestational alcohol intake at early organogenesis. CF-1 female mice were administered with 10% alcohol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received ethanol-free water...
August 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28820420/alterations-in-placenta-redox-status-during-experimental-model-of-hypoxia-induced-preeclampsia
#2
A Sharashenidze, L Panchulidze, T Sanikidze
An important pathogenetic link of preeclampsia (PE) is hypoxia of uterine-placental tissues, accompanied by damage of the vascular endothelium and the release of vasoactive mediators, violate vascular tone and microcirculation in the maternal organism and placenta and development of a number of pathological processes in the mother's and fetus body. The aim of the study was to establish metabolic abnormalities of oxidative metabolism of the placenta during experimental model of PE (uterine/placental hypoxia)...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28820418/pathological-adherence-of-placenta-case-reports
#3
R Sulukhia, L Melia, N Pirtskhalava, A Sukhiashvili
Major obstetric hemorrhage is the leading cause of maternal morbidity and mortality. In rare cases, life-threatening hemorrhage in pregnant women may result from abnormal adherence of placenta. Three grades of abnormal placental attachment are defined according to the depth of invasion: placenta accreta, placenta increta, and placenta percreta. An important risk factor for placenta abnormal adherence of placenta is placenta previa in the presence of a uterine scar. The increased prevalence of cesarean section, uterine surgery, and increasing parturient age and parity have led to an increased incidence of abnormal placentation, from one in 2,500 a quarter century ago, to one in 533 deliveries currently...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28818012/clinical-application-of-prophylactic-internal-iliac-artery-balloon-occlusion-combined-with-uterine-artery-embolization-in-patients-with-abnormally-invasive-placenta
#4
Youwen Mei, Dan Luo, Yonghong Lin
BACKGROUND: To investigate the role of prophylactic internal iliac artery balloon occlusion combined with uterine artery embolization (UAE) in patients with abnormally invasive placenta. METHODS: 40 cases with abnormally invasive placenta who visited our hospital were analyzed retrospectively from May 2014 to Sep 2015. 20 cases who had prophylactic balloon occlusion of internal iliac artery with/without UAE were in the study group, while the other 20 cases in the control group...
August 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28816389/clinical-indications-for-hysteroscopic-removal-of-uterine-masses-time-age-at-diagnosis-and-mass-size
#5
Hyun-Woong Cho, Yu-Jin Koo, Jin-Hwa Hong, Jae-Kwan Lee
AIM: The aim of this study was to investigate clinical factors associated with abnormal pathologies of uterine masses resected via hysteroscopy. METHODS: Women who underwent hysteroscopic surgery for presumptive diagnoses of abnormal endometrial or endocervical masses, such as polyps or leiomyomas on ultrasonography, between January 2012 and April 2015, were enrolled. Clinical and pathologic data were retrospectively reviewed. RESULTS: Among 189 patients, pathologic diagnoses of the uterine mass were abnormal in 172 (91...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28815854/expression-of-natural-cytotoxicity-receptors-and-cytokine-production-on-endometrial-natural-killer-cells-in-women-with-recurrent-pregnancy-loss-or-implantation-failure-and-the-expression-of-natural-cytotoxicity-receptors-on-peripheral-blood-natural-killer-cells
#6
Atsushi Fukui, Ayano Funamizu, Rie Fukuhara, Hiroaki Shibahara
AIM: Natural cytotoxicity receptors (NCR) are unique markers that regulate natural killer (NK) cell cytotoxicity and cytokine production. In this study, we investigated the expression of NCR (NKp46, NKp44, and NKp30) and cytokine production in NK cells derived from the uterine endometrium of women with recurrent pregnancy loss (RPL). We also investigated the expression of NCR in peripheral blood NK cells in pregnant women with and without a history of RPL. METHODS: The expression of NCR (NKp46, NKp44, and NKp30) in NK cells (CD56(dim) and CD56(bright) ) in the uterine endometrium was analyzed using 3-color flow cytometry...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28815020/advances-on-minimally-invasive-approach-for-benign-total-hysterectomy-a-systematic-review
#7
REVIEW
Marina de Paula Andres, Giuliano Moysés Borrelli, Mauricio Simões Abrão
Hysterectomy is one of the most commonly performed gynecologic surgeries, mainly for uterine myomas, abnormal uterine bleeding, and prolapses. It can be performed through several routes, each of which has its advantages and disadvantages. We conducted this systematic review to evaluate recent advances in surgical outcomes of benign total hysterectomies by any route: vaginal (VH), laparoscopic (LH), laparoscopically assisted vaginal (LAVH), single-port (SP), and robotic-assisted laparoscopy (RH). The search was applied to the PubMed electronic database by using keywords "hysterectomy" and "uterine benign disease", "adenomyosis", and "myoma"...
2017: F1000Research
https://www.readbyqxmd.com/read/28804623/recent-advances-in-the-molecular-mechanisms-of-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#8
Keiko Watanabe, Yusuke Kobayashi, Kouji Banno, Yusuke Matoba, Haruko Kunitomi, Kanako Nakamura, Masataka Adachi, Kiyoko Umene, Iori Kisu, Eiichiro Tominaga, Daisuke Aoki
Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a disease caused by congenital absence of the uterus and two-thirds of the upper vagina. The pathogenic mechanism of MRKHS may involve gene abnormalities, and there are various case reports associating MRKHS with the Wnt family member 4 (Wnt4) mutation. Analysis of genes mapped to regions in which deletion and duplication are frequently detected in patients with MRKHS has shown involvement of LIM homeobox 1 (LHX1), HNF1 homeobox B (HNF1B) and T-box 6 (TBX6)...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28803811/office-operative-hysteroscopy-an-update
#9
REVIEW
Christina Alicia Salazar, Keith Isaacson
Hysteroscopy is considered the gold standard for evaluation of intracavitary pathology associated with both pre- and postmenopausal patients with abnormal uterine bleeding as well as part of the evaluation of infertility patients with suspected cavity abnormalities. Office-based operative hysteroscopy allows patients to resume activities immediately and successfully integrates clinical practice into a "see and treat" modality, avoiding the added risks of undergoing anesthesia and the inconvenience of going to the operating room...
August 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28796898/comparison-of-the-levonorgestrel-releasing-intrauterine-system-hysterectomy-and-endometrial-ablation-for-heavy-menstrual-bleeding-in-a-decision-analysis-model
#10
REVIEW
Michelle Louie, Jennifer Spencer, Stephanie Wheeler, Victoria Ellis, Tarek Toubia, Lauren D Schiff, Matthew T Siedhoff, Janelle K Moulder
BACKGROUND: A better understanding of the relative risks and benefits of common treatment options for abnormal uterine bleeding (AUB) can help providers and patients to make balanced, evidence-based decisions. OBJECTIVES: To provide comparative estimates of clinical outcomes after placement of levonorgestrel-releasing intrauterine system (LNG-IUS), ablation, or hysterectomy for AUB. SEARCH STRATEGY: A PubMED search was done using combinations of search terms related to abnormal uterine bleeding, LNG-IUS, hysterectomy, endometrial ablation, cost-benefit analysis, cost-effectiveness, and quality-adjusted life years...
August 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28796688/optimal-order-of-successive-office-hysteroscopy-and-endometrial-biopsy-for-the-evaluation-of-abnormal-uterine-bleeding-a-randomized-controlled-trial
#11
Papri Sarkar, Emad Mikhail, Robyn Schickler, Shayne Plosker, Anthony N Imudia
OBJECTIVE: To estimate the optimal order of office hysteroscopy and endometrial biopsy when performed successively for evaluation of abnormal uterine bleeding. METHODS: Patients undergoing successive office hysteroscopy and endometrial biopsy were included in a single-blind, prospective, randomized trial. The primary outcome was to evaluate the effect of order of procedures on patients' pain score. Prespecified secondary outcomes include procedure duration, hysteroscopic visualization of the uterine cavity, endometrial sample adequacy, and number of attempts at biopsy...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28795408/novasure-radiofrequency-endometrial-ablation-for-the-management-of-acute-abnormal-uterine-bleeding
#12
Shamma Al-Inizi
Radiofrequency endometrial ablation resulted in abrupt cessation of acute abnormal uterine bleeding in one case, avoiding emergency hysterectomy. Acute abnormal uterine bleeding (AUB) unrelated to pregnancy is defined as an episode of bleeding that is sufficient in volume in the opinion of the treating clinician to require urgent or emergency intervention.(1) Acute AUB is a distressing condition that poses a challenge for clinicians and consumes healthcare resources. This article is protected by copyright. All rights reserved...
August 9, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28794456/activated-nk-cells-cause-placental-dysfunction-and-miscarriages-in-fetal-alloimmune-thrombocytopenia
#13
Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G Sled, Stephen J Lye, Jelena Brkić, Chun Peng, Petter Höglund, B Anne Croy, S Lee Adamson, Xiao-Yan Wen, Duncan J Stewart, John Freedman, Heyu Ni
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual immune cells or other abnormalities at the maternal-fetal interface contribute to FNAIT. Here we show that maternal immune responses to fetal platelet antigens cause miscarriage and IUGR that are associated with vascular and immune pathologies in murine FNAIT models...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28782473/importance-of-hemolysis-and-its-clinical-detection-in-neonates-with-hyperbilirubinemia
#14
Ronald J Wong, Vinod K Bhutani, David K Stevenson
Neonatal hyperbilirubinemia is generally a benign transitional phenomenon, and may even be a protective antioxidant mechanism for human neonates who may be vulnerable to the oxidative stress (compared to life in utero) encountered during birth an extra-uterine oxidative environment (1, 2). The pathophysiologic impact of neonatal unconjugated hyperbilirubinemia has been well reviewed in this supplement (see Jon fill-in). The severity of hyperbilirubinemia varies due to the magnitude of an imbalance between two major contributing processes: (i) an increase bilirubin production rate due to an increase in heme turnover (two to three times that of an adult) due to the degradation of fetal red blood cells (RBCs), which have a shortened lifespan, after birth (3, 4); and/or (ii) a diminished ability of the immature newborn liver to conjugate bilirubin and therefore excrete bilirubin in bile...
August 7, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28782171/longitudinal-growth-assessment-for-the-prediction-of-adverse-perinatal-outcome-in-sga-suspected-fetuses
#15
Javier Caradeux, Elisenda Eixarch, Edurne Mazarico, Tri Rahmat Basuki, Eduard Gratacos, Francesc Figueras
BACKGROUND: Fetal growth restriction (FGR) is associated with an increased risk of adverse perinatal outcome (APO). However, distinguishing this condition from smallness-for-gestational age remains elusive. A set of criteria has recently been proposed for such purpose, including the severity of smallness, Doppler parameters and growth velocity. OBJECTIVES: To establish whether the use of growth velocity adds to Doppler evaluation in predicting APO among SGA-suspected fetuses...
August 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28780893/abnormal-uterine-bleeding-in-perimenopause
#16
S R Goldstein, M A Lumsden
Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Once a proper diagnosis has been established, appropriate therapy may be embarked upon...
August 7, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28770968/lncrna-malat1-promotes-proliferation-and-metastasis-in-epithelial-ovarian-cancer-via-the-pi3k-akt-pathway
#17
Y Jin, S-J Feng, S Qiu, N Shao, J-H Zheng
OBJECTIVE: The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that plays a key role in the malignant phenotype of tumors. Although abnormal regulation of lncRNA MALAT1 impacts clinical prognostic and tumor metastasis, its function remains unclear in ovarian cancer. PATIENTS AND METHODS: We collected 64 samples of surgical EOC tissues and 30 samples of normal ovarian tissues at the Department of Gynecology of Harbin Medical University (Harbin, China)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770405/invasive-placenta-previa-placental-bulge-with-distorted-uterine-outline-and-uterine-serosal-hypervascularity-at-1-5t-mri-useful-features-for-differentiating-placenta-percreta-from-placenta-accreta
#18
Xin Chen, Ruiqin Shan, Lianxin Zhao, Qingxu Song, Changting Zuo, Xinjuan Zhang, Shanshan Wang, Honglu Shi, Fei Gao, Tianyi Qian, Guangbin Wang, Catherine Limperopoulos
OBJECTIVES: To characterise MRI features of invasive placenta previa and to identify specific features for differentiating placenta percreta (PP) from placenta accreta (PA). METHODS: Forty-five women with PP and 93 women with PA who underwent 1.5T placental MRI were included. Two radiologists independently evaluated the MRI features of invasive placenta previa, including our novel type of placental bulge (i.e. placental bulge type-II, characterized by placental bulge with distorted uterine outline)...
August 2, 2017: European Radiology
https://www.readbyqxmd.com/read/28763739/risk-of-malignancy-on-suspicion-of-polyps-in-menopausal-women
#19
Sandra Bel, Camille Billard, Julien Godet, Victor Viviani, Cherif Akladios, Aline Host, Emilie Faller, Thomas Boisrame, Michel Hummel, Jean-Jacques Baldauf, Lise Lecointre, Olivier Garbin
Improved performances in gynaecological ultrasonography have enabled an increasing number of often asymptomatic endometrial polyps to be detected. Most of these polyps are removed surgically, as a precautionary measure, so as not to miss a case of endometrial cancer. Nonetheless, this management strategy is based solely on the sonographer's judgement and a number of these operations, which are probably of no benefit, could be avoided. In order to do so, risk factors for malignancy need to be identified. OBJECTIVE: Estimate the prevalence of lesions in menopausal patients with a pre-operative diagnosis of endometrial polyp...
July 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28757335/imaging-in-cutis-laxa-syndrome-caused-by-a-dominant-negative-aldh18a1-mutation-with-hypotheses-for-intracranial-vascular-tortuosity-and%C3%A2-wide-perivascular-spaces
#20
P F Sinnige, C M A van Ravenswaaij-Arts, P Caruso, A E Lin, M Boon, E Rahikkala, B Callewaert, L C Meiners
The autosomal dominant progeroid form of cutis laxa is a recently identified multiple congenital anomaly disorder characterized by thin, wrinkled skin, a progeroid appearance, intra-uterine growth retardation, postnatal growth restriction, psychomotor developmental delay, microcephaly, cataract, hypotonia and contractures. De novo heterozygous mutations in ALDH18A1 have been described in this condition. We present neuroimaging abnormalities in three patients. One patient had intracranial arterial and venous tortuosity, widened ventricular and extra-axial cerebrospinal fluid (CSF) spaces, wide perivascular spaces and increased T2 signal intensity in the cerebral white matter over time...
July 18, 2017: European Journal of Paediatric Neurology: EJPN
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