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https://www.readbyqxmd.com/read/27913486/heavy-menstrual-bleeding-work-up-and-management
#1
Andra H James
Heavy menstrual bleeding (HMB), which is the preferred term for menorrhagia, affects ∼90% of women with an underlying bleeding disorder and ∼70% of women on anticoagulation. HMB can be predicted on the basis of clots of ≥1 inch diameter, low ferritin, and "flooding" (a change of pad or tampon more frequently than hourly). The goal of the work-up is to determine whether there is a uterine/endometrial cause, a disorder of ovulation, or a disorder of coagulation. HMB manifest by flooding and/or prolonged menses, or HMB accompanied by a personal or family history of bleeding is very suggestive of a bleeding disorder and should prompt a referral to a hematologist...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27904431/term-live-secondary-abdominal-pregnancy-a-case-report
#2
Deepika Pannu, Rekha Bharti, H P Anand, Manjula Sharma
Term, live abdominal pregnancy secondary to rupture of a uterine rudimentary horn is a rare condition. Pregnancies conceived in the rudimentary horn of the uterus usually rupture during early gestation and present as a catastrophic event. However, rarely, after rupture of the uterine horn the foetus may continue to grow in the abdominal cavity and reach term gestation. A primigravida with a term pregnancy was referred to our centre for caesarean section with ultrasonography findings of transverse lie and placenta previa...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27903446/polycystic-ovary-syndrome-an-under-recognized-cause-of-abnormal-uterine-bleeding-in-adolescents-admitted-to-a-children-s-hospital
#3
Sofya Maslyanskaya, Hina J Talib, Jennifer L Northridge, Amanda M Jacobs, Chanelle Coble, Susan M Coupey
STUDY OBJECTIVE: To evaluate whether ovulatory dysfunction due to polycystic ovary syndrome (PCOS) is a common underlying etiology of abnormal uterine bleeding (AUB) in adolescents requiring hospitalization and to explore etiology, treatment and complications of AUB with severe anemia in adolescents. DESIGN: We identified females aged 8 to 20 years admitted to a children's hospital for treatment of AUB from January 2000 to December 2014. Our hospital protocol advises hormonal testing for PCOS and other disorders prior to treatment for AUB...
November 26, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27899973/expression-patterns-of-maspin-and-mutant-p53-are-associated-with-the-development-of-gestational-trophoblastic-neoplasia
#4
Pengming Sun, Qibin Wu, Guanyu Ruan, Xiu Zheng, Yiyi Song, Jianfan Zhun, Lixiang Wu, Walter H Gotlieb
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GTN from HMs. The current study evaluated the expression of maspin and tumor protein p53 (p53) in GTD, and their role in predicting the development of GTN...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895740/letrozole-as-second-line-hormonal-treatment-for-recurrent-low-grade-endometrial-stromal-sarcoma-a-case-report-and-review-of-the-literature
#5
Kohei Nakamura, Kentaro Nakayama, Masako Ishikawa, Noriyoshi Ishikawa, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Emi Sato, Kohji Iida, Razia Sultana, Satoru Kyo
Low-grade endometrial stromal sarcoma (LGESS) is a rare malignancy. The tumor is reportedly responsive to hormonal therapy, most commonly with medroxyprogesterone acetate (MPA), but the effectiveness of aromatase inhibitors for recurrent LGESS remains unclear. The present study reports a case of stage IC LGESS presenting with abnormal uterine bleeding, and also provides a review of the literature. Following a total abdominal hysterectomy and bilateral salpingo-oophorectomy, MPA therapy was initiated; treatment was successful, but discontinued 19 months later due to disruptive side effects...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889460/evaluation-of-time-lapse-for-establishing-distal-tubal-occlusion-diagnosis-during-hysterosalpingography-procedure-performed-by-using-water-soluble-contrast-media
#6
Serkan Kahyaoglu, Omer Hamid Yumusak, Inci Kahyaoglu, Gokce Naz Kucukbas, Alev Esercan, Yasemin Tasci
BACKGROUND: Hysterosalpingography (HSG) is the most frequently used diagnostic measure for simultaneously determining uterine abnormalities and tubal status among subfertile women. Despite several broader advantages such as availability and increased experience, the subjectivity involved during administration of the HSG procedure itself, and necessary imaging review, decreases the reliability and accuracy of HSG. In this study, we evaluated the time intervals between X-ray imaging during HSG procedure to establish the presence of distal tubal occlusion...
November 24, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27885327/surgical-removal-of-an-extrauterine-device-migrating-to-appendix
#7
Gulsum Uysal, Hakan Nazik, Nefise Tanridan Okçu, Sevtap Seyfettinoglu, Halil Kazgan
Intrauterine devices (IUDs) remain highly effective reversible family planning methods in developing countries. We aimed to report one of the complications of extrauterine and intrauterine devices. A 44-year-old woman was admitted to our hospital with mislocated intrauterine device and abnormal uterine bleeding. Extrauterine IUD device was proven by ultrasound and X-ray. She had normal blood test count with a negative pregnancy test. There are several cases of complications with intrauterine devices, but this is the first case report about an extrauterine IUD embedded by inflame enlarged appendix presenting with abnormal uterine bleeding...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27883242/sflt-1-plgf-for-early-onset-pre-eclampsia-prediction-steps-study-of-early-pre-eclampsia-in-spain
#8
A Perales, J L Delgado, M De La Calle, J A García-Hernández, A I Escudero, J M Campillos, M D Sarabia, B Laíz, M Duque, M Navarro, P Calmarza, M Hund, F V Álvarez
OBJECTIVES: A high ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) has been linked with pre-eclampsia (PE). We evaluated the sFlt-1/PlGF ratio as a predictive marker for early-onset PE in women at risk of PE. METHODS: This prospective, Spanish, multicenter study included pregnant women with PE risk factors (including: history of intrauterine growth restriction; PE; eclampsia; hemolysis, elevated liver enzymes and low platelet count syndrome; pre-gestational diabetes; and abnormal uterine artery Doppler ultrasound)...
November 24, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27882232/metastatic-gastric-cancer-to-the-female-genital-tract
#9
Hiroshi Matsushita, Kazushi Watanabe, Akihiko Wakatsuki
Metastases to the female genital tract from gastric cancer are rare, but they significantly worsen the prognosis of such patients. The potential routes for metastasis to the female genital tract from gastric cancer include hematogenous spread, lymphatic spread and surface implantation. The rate of lymphatic metastasis to the ovary from gastric cancer has been reported to be higher compared with that from colorectal cancer. Uterine or Fallopian tube metastases are usually secondary to ovarian metastases, which are typically identified prior to the detection of gastric cancer in half of all synchronous cases, with complaints of abdominal distention, pain, palpable mass, or abnormal uterine bleeding...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27878356/phase-i-trial-of-daily-triapine-in-combination-with-cisplatin-chemotherapy-for-advanced-stage-malignancies
#10
Charles A Kunos, Edward Chu, Jan H Beumer, Mario Sznol, S Percy Ivy
PURPOSE: Advanced-stage malignancies have increased deoxyribonucleotide demands in DNA replication and repair, making deoxyribonucleotide supply a potential exploitable target for therapy based on ribonucleotide reductase (RNR) inhibition. METHODS: A dose-finding phase I trial was conducted of intravenous (i.v.) triapine, a small-molecule RNR inhibitor, and cisplatin chemotherapy in patients with advanced-stage solid tumor malignancies. Patients received dose-finding levels of i...
November 22, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27873054/expectant-management-may-reduce-overtreatment-in-women-affected-by-unexplained-infertility-confirmed-by-diagnostic-laparoscopy
#11
S De Cicco, Valeria Tagliaferri, L Selvaggi, D Romualdi, C Di Florio, V Immediata, A Lanzone, M Guido
PURPOSE: To determine whether the mini-invasive surgery still play a role in the diagnostic workup and in the management of the couples affected by unexplained infertility. METHODS: 170 infertile women (age range 25-38 years) with documented normal ovarian, tubal and uterine function underwent combined hysteroscopic and laparoscopic surgery; 100 women refused surgery or ART treatment (control group) choosing expectant management. A retrospective assessment questionnaire was proposed to enrolled women to collect the rate of spontaneous or ART-induced pregnancies...
November 21, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27871464/downregulation-of-mir-29a-b-c-in-placenta-accreta-inhibits-apoptosis-of-implantation-site-intermediate-trophoblast-cells-by-targeting-mcl1
#12
Yongzhong Gu, Yuehong Bian, Xiaofei Xu, Xietong Wang, Changting Zuo, Jinlai Meng, Hongyan Li, Shigang Zhao, Yunnan Ning, Yongzhi Cao, Tao Huang, Junhao Yan, Zi-Jiang Chen
OBJECTIVE: Placenta accreta is defined as abnormal adhesion of placental villi to the uterine myometrium. Although this condition has become more common as a result of the increasing rate of cesarean sections, the underlying causative mechanism(s) remain elusive. Because microRNA-29a/b/c (miR-29a/b/c) have been shown to play important roles in placental development, this study evaluated the roles of these microRNAs in placenta accreta. METHODS: Expression of miR-29a/b/c and myeloid cell leukemia-1 (MCL1) were quantified in patient tissues and HTR8/SVneo trophoblast cells using the real-time quantitative polymerase chain reaction...
December 2016: Placenta
https://www.readbyqxmd.com/read/27868455/identification-of-patients-at-risk-for-preeclampsia-with-the-use-of-uterine-artery-doppler-velocimetry-and-copeptin
#13
Ali Yeşil, Ammar Kanawati, Çağlar Helvacıoğlu, Cihan Kaya, Çağseli Göksu Özgün, Hüseyin Cengiz
PURPOSE: To investigate the relationship between maternal copeptin levels and uterine artery Doppler examination and progress of preeclampsia. MATERIALS AND METHODS: A cross-sectional study was designed with women those were screened at 20 + 0 - 24 + 6 weeks' gestation between May 2014 and August 2014. The obstetric records of all normotensive women were examined. Uterine artery Doppler velocimetry results and serum copeptin levels were measured. The patients were divided in two groups according to normal (n = 67) and abnormal uterine artery Doppler (n = 21) findings...
November 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27863914/cultural-aspects-and-mythologies-surrounding-menstruation-and-abnormal-uterine-bleeding
#14
REVIEW
Delfin A Tan, Rohana Haththotuwa, Ian S Fraser
The objective of this chapter is to present an overview of how menstruation, a normal bodily function, was and is perceived in various ethnic groups and cultures in the world, from ancient mythology, historical, or traditional practices to contemporary belief systems. Mythical tales about menstruation abound in the legends and prehistory of ancient cultures. These tales characterize menstrual blood variously as sacred, a gift from the gods, or a punishment for sin, but it is almost always magical and powerful...
October 26, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27862503/accuracy-of-saline-contrast-sonohysterography-in-detection-of-endometrial-polyps-and-submucosal-leiomyoma-in-women-at-reproductive-age-with-abnormal-uterine-bleeding-a-systematic-review-and-meta-analysis
#15
REVIEW
Carolina Abdou Bittencourt, Ricardo Dos Santos Simões, Wanderley Marques Bernardo, Luiz Fernando Portugal Fuchs, José Maria Soares Junior, Ayrton Roberto Pastore, Edmund Chada Baracat
OBJECTIVE: To analyze the diagnostic accuracy of 2D and 3D saline contrast sonohysterography compared to hysteroscopy in the detection of endometrial polyps and submucosal myomas in women during reproductive age with abnormal uterine bleeding. METHOD: A systematic review of diagnostic studies that compared saline contrast sonohysterography with hysteroscopy was conducted according to the PRISMA and SEDATE recommendations. Only studies that compared two and/or three dimensional saline contrast sonohysterography with hysteroscopy and anatomopathology were included...
November 15, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27862412/infertility-associated-with-the-absence-of-endometrial-progesterone-receptors-in-a-bitch
#16
J C Dockweiler, B Cossic, C G Donnelly, R O Gilbert, E Buckles, S H Cheong
A three-year-old intact female Old English sheepdog was presented for evaluation of infertility. A uterine biopsy was performed during dioestrus, and the microscopic appearance was inconsistent with progesterone stimulation; the glands were sparse, simple and failed to show coiling, while the glandular epithelium was cuboidal instead of columnar. There was very little evidence of glandular activity. Due to the inappropriate appearance of the glands for the stage of the cycle, immunohistochemistry for progesterone receptors was performed...
November 14, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27861360/association-between-uterine-leiomyoma-and-metabolic-syndrome-in-parous-premenopausal-women-a-case-control-study
#17
Young Jin Tak, Sang Yeoup Lee, Sun Ki Park, Yun Jin Kim, Jeong Gyu Lee, Dong Wook Jeong, Seung Chul Kim, In Joo Kim, Yu Hyun Yi
Previous studies have reported that uterine leiomyoma (UL) may share pathogenic features with obesity and hypertension, which are components of metabolic syndrome (MetS). We examined the association between UL and MetS in premenopausal parous women.This 1:1 case-control study was conducted on 615 asymptomatic women with UL and 615 women without UL that were matched for age, reproductive history, and hormonal use, who underwent a comprehensive health examination. UL was diagnosed by a gynecologist based on transvaginal ultrasonography findings...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27859836/outcome-in-monochorionic-twin-pregnancies-with-selective-intrauterine-growth-restriction-according-to-the-umbilical-artery-doppler-pattern-of-the-smaller-twin-a-systematic-review-and-meta-analysis
#18
REVIEW
Danilo Buca, Giorgio Pagani, Giuseppe Rizzo, Alessandra Familiari, Maria Elena Flacco, Lamberto Manzoli, Marco Liberati, Francesco Fanfani, Giovanni Scambia, Francesco D'Antonio
OBJECTIVE: To explore the outcome of monochorionic (MC) twin pregnancies affected by selective intra-uterine growth restriction (sIUGR) according to the umbilical artery Doppler pattern of the smaller twin. METHODS: Medline, Embase, Cinhal and ClinicalTrials.gov databases (2000-2016) were searched. sIUGR was defined as the presence of one twin with estimated fetal weight and/or abdominal circumference less than 10(th) or 5(th) percentile and classified according to the umbilical artery Doppler flow pattern of the smaller twin (type I: persistently positive, type II: persistently absent/reversed, type III: intermittently absent/reversed)...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27858967/placental-pulsatility-index-a-new-more-sensitive-parameter-for-predicting-adverse-outcome-in-pregnancies-suspected-of-fetal-growth-restriction
#19
Saemundur Gudmundsson, Kari Flo, Gisela Ghosh, Tom Wilsgaard, Ganesh Acharya
INTRODUCTION: The pulsatility indices (PI) of the umbilical (UA) and uterine (UtA) arteries are used as the surrogate measures of utero-placental perfusion. Combining the two might simplify the evaluation of total placental vascular impedance, possibly improve prediction of adverse outcomes and help to identify pregnancies with suspected fetal growth restriction that need more intense surveillance. MATERIAL AND METHODS: UA and UtA blood flow velocities were recorded using pulsed-wave Doppler in a longitudinal study of 53 low-risk pregnancies (248 observations) during 20-40 weeks of gestation...
November 17, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27854384/short-term-outcome-of-periviable-small-for-gestational-age-babies-is-our-counseling-up-to-date
#20
A R Lawin-O'Brien, A Dall'Asta, C Knight, S Sankaran, C Scala, A Khalil, A Bhide, S Heggarty, A Rakow, D Pasupathy, A T Papageorghiou, C C Lees
OBJECTIVE: There are limited data for counseling on and management of periviable small-for-gestational-age (SGA) fetuses. We therefore aimed to investigate the short-term outcome of periviable SGA fetuses in relation to the likely underlying cause. METHODS: This was a retrospective study of data from three London tertiary fetal medicine centers obtained between 2000 and 2015. We included viable singleton pregnancies with a severely small fetus, defined as those with an abdominal circumference ≤ 3(rd) percentile, identified between 22 + 0 and 25 + 6 weeks' gestation...
November 2016: Ultrasound in Obstetrics & Gynecology
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