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https://www.readbyqxmd.com/read/28445937/methylation-mediated-silencing-of-microrna-211-promotes-cell-growth-and-epithelial-to-mesenchymal-transition-through-activation-of-the-akt-%C3%AE-catenin-pathway-in-gbm
#1
Weidong Li, Xiaobo Miao, Lingling Liu, Yue Zhang, Xuejun Jin, Xiaojun Luo, Hai Gao, Xubin Deng
Aberrant expression of miR-211 has frequently been reported in cancer studies; however, its role in glioblastoma multiforme (GBM) has not been examined in detail. We investigated the function and the underlying mechanism of miR-211 in GBM. We revealed that miR-211 was downregulated in GBM tissues and cell lines. Restoration of miR-211 inhibited GBM cell growth and invasion both in vitro and in vivo. The epithelial to mesenchymal transition (EMT) phenotype was reversed when miR-211 expression was restored. HMGA2 was identified as a down-stream target of miR-211...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445765/in-line-monitoring-and-optimization-of-powder-flow-in-a-simulated-continuous-process-using-transmission-near-infrared-spectroscopy
#2
Md Anik Alam, Zhenqi Shi, James K Drennen, Carl A Anderson
In-line monitoring of continuous powder flow is an integral part of the continuous manufacturing process of solid oral dosage forms in the pharmaceutical industry. Specifically, monitoring downstream from loss-in-weight (LIW) feeders and/or continuous mixers provides important data about the state of the process. Such measurements support control of the process and thereby enhance product quality. Near Infrared Spectroscopy (NIRS) is a potential PAT tool to monitor the homogeneity of a continuous powder flow stream in pharmaceutical manufacturing...
April 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28445000/vegetation-response-to-control-of-invasive-tamarix-in-southwestern-us-rivers-a-collaborative-study-including-416-sites
#3
Eduardo González, Anna A Sher, Robert M Anderson, Robin F Bay, Daniel W Bean, Gabriel J Bissonnete, Bérenger Bourgeois, David J Cooper, Kara Dohrenwend, Kim D Eichhorst, Hisham El Waer, Deborah K Kennard, Rebecca Harms-Weissinger, Annie L Henry, Lori J Makarick, Steven M Ostoja, Lindsay V Reynolds, W Wright Robinson, Patrick B Shafroth
Most studies assessing vegetation response following control of invasive Tamarix trees along southwestern U.S. rivers have been small in scale (e.g., river reach), or at a regional scale but with poor spatial-temporal replication, and most have not included testing the effects of a now widely-used biological control. We monitored plant composition following Tamarix control along hydrologic, soil and climatic gradients in 244 treated and 172 reference sites across six U.S. States. This represents the largest comprehensive assessment to date on the vegetation response to the four most common Tamarix control treatments...
April 26, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28444498/competition-of-multiple-species-in-advective-environments
#4
Olga Vasilyeva
We study the effect of changes in flow speed on competition of an arbitrary number of species living in advective environments, such as streams and rivers. We begin with a spatial Lotka-Volterra model which is described by n reaction-diffusion-advection equations with Danckwerts boundary conditions. Using the dominant eigenvalue [Formula: see text] of the diffusion-advection operator subject to boundary conditions, we reduce the model to a system of ordinary differential equations. We impose a "transitive arrangement" of the competitors in terms of their interspecific coefficients and growth rates, which means that in the absence of advection, we have the following situation: for all [Formula: see text], species i out-competes species j, while species j has higher intrinsic growth rate than species i...
April 25, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28444412/biochemical-and-genetic-analyses-of-n-metabolism-in-maize-testcross-seedlings-1-leaves
#5
Ignacio Trucillo Silva, Hari Kishan R Abbaraju, Lynne P Fallis, Hongjun Liu, Michael Lee, Kanwarpal S Dhugga
Aside from the identification of 32 QTL for N metabolism in the seedling leaves of a maize testcross population, alanine aminotransferase was found to be a central enzyme in N assimilation. Excessive application of nitrogen (N) fertilizer to grow commercial crops like maize is a cause of concern because of the runoff of excess N into streams and rivers. Breeding maize with improved N use efficiency (NUE) would reduce environmental pollution as well as input costs for the farmers. An understanding of the genetics underlying N metabolism is key to breeding for NUE...
April 25, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28444300/reproductive-justice-a-policy-window-for-social-work-advocacy
#6
Brenda D Smith
Reproductive rights are at risk in many parts of the United States. To inspire social workers to act, this article begins by defining and describing the concepts of reproductive rights and reproductive justice. Next, it summarizes threats to reproductive rights in five areas: preventing pregnancy, terminating pregnancy, pregnancy loss, personhood measures, and drug use during pregnancy. Applying John Kingdon's policy streams framework, the article urges more social workers to embrace the current policy window and advocate for pregnant women and others whose reproductive rights are in jeopardy...
April 21, 2017: Social Work
https://www.readbyqxmd.com/read/28443914/probing-the-pharmacokinetics-of-cucurbit-7-8-and-10-uril-and-a-dinuclear-ruthenium-antimicrobial-complex-encapsulated-in-cucurbit-10-uril
#7
Fangfei Li, Anil K Gorle, Marie Ranson, Kara L Vine, Robert Kinobe, Marshall Feterl, Jeffrey M Warner, F Richard Keene, J Grant Collins, Anthony I Day
The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples of pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK studies are the next step in determining the pharmacological applicability in their drug delivery potential. The results for the first PK and bio-distribution of drug-free (14)C-Q[7] are described for administration via intravenous (i.v.) and intraperitoneal (i.p.) dosing. A study of oral administration of drug-free (14)C-Q[8] has also been undertaken to determine the time course for the gastrointestinal tract (GIT), absorption and subsequent bio-distribution...
April 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28443612/dynamically-unpolarized-single-photon-source-in-diamond-with-intrinsic-randomness
#8
Naofumi Abe, Yasuyoshi Mitsumori, Mark Sadgrove, Keiichi Edamatsu
Polarization is one of the fundamental properties of light, providing numerous applications in science and technology. While 'dynamically unpolarized' single-photon sources are demanded for various quantum applications, such sources have never been explored. Here we demonstrate dynamically unpolarized single-photon emission from a single [111]-oriented nitrogen- vacancy centre in diamond, in which the single-photon stream is unpolarized, exhibiting intrinsic randomness with vanishing polarization correlation between time adjacent photons...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28443003/complementary-modular-microcircuits-of-the-rat-medial-entorhinal-cortex
#9
Saikat Ray, Andrea Burgalossi, Michael Brecht, Robert K Naumann
The parahippocampal region is organized into different areas, with the medial entorhinal cortex (MEC), presubiculum and parasubiculum prominent in spatial memory. Here, we also describe a region at the extremity of the MEC and bordering the subicular complex, the medial-most part of the entorhinal cortex. While the subdivisions of hippocampus proper form more or less continuous cell sheets, the superficial layers of the parahippocampal region have a distinct modular architecture. We investigate the spatial distribution, laminar position, and putative connectivity of zinc-positive modules in layer 2 of the MEC of rats and relate them to the calbindin-positive patches previously described in the entorhinal cortex...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28442857/influence-of-blood-flow-on-the-neuroma-formation-after-transposition-of-the-nerve-stump-into-vein-experimental-and-clinical-study
#10
Hossam El-Din Ali Ismail, Mohamed Ali Kasem, Fatma El-Hossiney Mostafa
We study the influence of blood flow on the neuroma formation after transposition of the nerve stump into a vein. A total of 30 rats were divided into two groups. In group (I), a 10-mm segment of the femoral vein was excluded from the blood stream. A venotomy was performed in the middle of this segment. The proximal nerve stump of femoral nerve was transposed into the lumen of the femoral vein via a venotomy and held with an epineural suture through the venous wall. In group (II), the same technique was used as in group (I) but without exclusion of the vein segment from blood flow...
April 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/28442767/direct-rapid-antimicrobial-susceptibility-test-from-positive-blood-cultures-based-on-microscopic-imaging-analysis
#11
Jungil Choi, Hyun Yong Jeong, Gi Yoon Lee, Sangkwon Han, Shinhun Han, Bonghwan Jin, Taegeun Lim, Shin Kim, Dong Young Kim, Hee Chan Kim, Eui-Chong Kim, Sang Hoon Song, Taek Soo Kim, Sunghoon Kwon
For the timely treatment of patients with infections in bloodstream and cerebrospinal fluid, a rapid antimicrobial susceptibility test (AST) is urgently needed. Here, we describe a direct and rapid antimicrobial susceptibility testing (dRAST) system, which can determine the antimicrobial susceptibility of bacteria from a positive blood culture bottle (PBCB) in six hours. The positive blood culture sample is directly mixed with agarose and inoculated into a micropatterned plastic microchip with lyophilized antibiotic agents...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442762/first-you-need-a-gestalt-an-interaction-of-bottom-up-and-top-down-streams-during-the-perception-of-the-ambiguously-rotating-human-walker
#12
Alexander Pastukhov
Our visual system combines sensory evidence with prior knowledge to produce a representation of an outside world. Here, we explored the limits of the feedforward computation using an ambiguously rotating human biological motion. Specifically, we investigated whether an overall rotation, which was added to all the displays used in the study, would be perceived when the point-light walker was presented upside-down, a condition that typically obliterates perception of a human Gestalt. We report that inversion of the point-light walker or the absence of an identifiable Gestalt abolished the perception of an overall rotation...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442740/deciphering-the-mode-of-action-of-cell-wall-inhibiting-antibiotics-using-metabolic-labeling-of-growing-peptidoglycan-in-streptococcus-pyogenes
#13
Atsushi Sugimoto, Asuka Maeda, Kaori Itto, Hirokazu Arimoto
Because of the scanty pipeline of antibiotics newly obtained from nature, chemical modification of established drugs is one of the major streams of current antibacterial research. Intuitive and easy-to-use assays are critical for identifying drug candidates with novel modes of action. In this study, we demonstrated that metabolic fluorescent staining of growing cell walls is a powerful tool for mode-of-action analyses of antibiotics using Streptococcus pyogenes. A set of major cell-wall-inhibiting antibiotics (bacitracin, D-cycloserine, flavomycin, oxacillin, ramoplanin, and vancomycin) was employed to validate the potential of the assay...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442557/high-phosphate-induces-a-pro-inflammatory-response-by-vascular-smooth-muscle-cells-modulation-by-vitamin-d-derivatives
#14
Julio M Martínez-Moreno, Carmen Herencia, Addy Montes de Oca, Juan M Díaz-Tocados, Noemi Vergara, Mª José Gomez, Silvia D López-Argüello, Antonio Camargo, Esther Peralbo-Santaella, Maria E Rodríguez-Ortiz, Antonio Canalejo, Mariano Rodriguez, Juan J Muñoz-Castañeda, Yolanda Yolanda Almaden
In chronic kidney disease patients, high phosphate (HP) levels are associated to cardiovascular disease, the major cause of morbidity and mortality. Since serum phosphate has been independently correlated with inflammation, the present study aimed to investigate an independent direct effect of HP as a pro-inflammatory factor in VSMCs. A possible modulatory effect of vitamin D was also investigated. The study was performed in an in vitro model of human aortic smooth muscle cells (HASMCs). Incubation of cells in a HP (3...
April 25, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28442173/analysis-of-tar-compounds-and-quantification-of-naphthalene-from-thermal-treatment-of-household-biowaste
#15
S Vakalis, F Patuzzi, K Moustakas, A Sotiropoulos, D Malamis, M Baratieri
Household biowaste represent the organic fraction of municipal solid waste and are an underutilized resource. Although previous studies have performed pyrolysis of organic waste, the vast majority has been on specific presorted feedstock or conventional lignocellulosic streams. Therefore, there is a lack of pyrolysis applications on representative food waste as retrieved from households and this can be attributed primarily to their high water content and their degradability. But via the intermediate step of drying, long-term storage and thermal treatment have become possible...
April 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28441919/si-based-technologies-for-reduction-of-the-pollutant-leaching-from-landfills-and-mine-tails
#16
E Bocharnikova, V Matichenkov, J Jiang, C Yuejin
Monosilicic and polysilicic acids were shown to react with different types of the pollutants. The direction of these reactions can be managed by changing the monosilicic and polysilicic acid concentration in soil or water media. The objective of this study was to determine the effect of Si-treated calcium metallurgical slag and battery slag on the As, Se, Cd, Pb, Ni, Cr, and Hg mobility and bioavailability in mine tailings (Xikuangshan mine, Hunan, China). The results of column experiment showed that the Si-activated slags reduced leaching of As, Se, Cd, Pb, Ni, Cr, and Hg by 12 to 88% and transformed them into plant-unavailable forms...
April 25, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28441866/interactions-of-insoluble-residue-from-enzymatic-hydrolysis-of-brewer-s-spent-grain-with-intestinal-microbiota-in-mice
#17
Johanna Maukonen, Anna-Marja Aura, Piritta Niemi, Gulam Shere Raza, Klaus Niemela, Jaroslaw Walkowiak, Ismo Mattila, Kaisa Poutanen, Johanna Buchert, Karl-Heinz Herzig
Brewer's spent grain (BSG) is the major side-stream from brewing. As BSG is rich in dietary fiber and protein, it could be used in more valuable applications, such as nutritional additives for foods. Our aim was to elucidate whether a insoluble lignin-rich fraction (INS) from BSG is metabolized by mice gut microbiota and how it affects the microbiota. Our results indicated that lignin was partially degraded by the gut microbiota, degradation products were absorbed, and finally excreted in urine. Therefore, they contribute to the phenolic pool circulating in the mammalian body, and may have systemic effects on health...
April 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28441601/improving-understanding-of-mixed-land-use-watershed-suspended-sediment-regimes-mechanistic-progress-through-high-frequency-sampling
#18
Elliott Kellner, Jason A Hubbart
Given the importance of suspended sediment to biogeochemical functioning of aquatic ecosystems, and the increasing concern of mixed-land-use effects on pollutant loading, there is an urgent need for research that quantitatively characterizes spatiotemporal variation of suspended sediment dynamics in contemporary watersheds. A study was conducted in a representative watershed of the central United States utilizing a nested-scale experimental watershed design, including five gauging sites (n=5) partitioning the catchment into five sub-watersheds...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441597/differences-in-nitrate-and-phosphorus-export-between-wooded-and-grassed-riparian-zones-from-farmland-to-receiving-waterways-under-varying-rainfall-conditions
#19
Amanda D Neilen, Chengrong R Chen, Brett M Parker, Stephen J Faggotter, Michele A Burford
Agricultural activities in catchments can cause excessive nutrient loads in waterways. Catchment nitrogen (N) and phosphorus (P) flows may be intercepted and assimilated by riparian vegetation. While prior studies suggest that woody vegetation is preferable for reducing P loads, the question remains: is woody vegetation or grass cover more effective at reducing catchment N and P exports to waterways. To address this we investigated the relative importance of vegetation type, hydrologic and soil microbial processes on N and P losses from soil to a stream...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441386/graft-derived-cell-free-dna-a-noninvasive-early-rejection-and-graft-damage-marker-in-liver-transplantation-a-prospective-observational-multicenter-cohort-study
#20
Ekkehard Schütz, Anna Fischer, Julia Beck, Markus Harden, Martina Koch, Tilo Wuensch, Martin Stockmann, Björn Nashan, Otto Kollmar, Johannes Matthaei, Philipp Kanzow, Philip D Walson, Jürgen Brockmöller, Michael Oellerich
BACKGROUND: Graft-derived cell-free DNA (GcfDNA), which is released into the blood stream by necrotic and apoptotic cells, is a promising noninvasive organ integrity biomarker. In liver transplantation (LTx), neither conventional liver function tests (LTFs) nor immunosuppressive drug monitoring are very effective for rejection monitoring. We therefore hypothesized that the quantitative measurement of donor-derived cell-free DNA (cfDNA) would have independent value for the assessment of graft integrity, including damage from acute rejection...
April 2017: PLoS Medicine
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