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https://www.readbyqxmd.com/read/27933735/danazol-has-potential-to-cause-pkc-translocation-cell-cycle-dysregulation-and-apoptosis-in-breast-cancer-cells
#1
Suman Jyoti Deka, Ashalata Roy, Vibin Ramakrishnan, Debasis Manna, Vishal Trivedi
Danazol, the established clinical drug has given promising therapeutic results in a series of clinical trials with breast cancer patients. Danazol shares structural similarities with several known PKC agonists and fits well into the C1 domain. Danazol binds to the C1b domain of PKC with Kd of 5.64±1.27 μM. MD simulation studies further support that the PKC-Danazol molecular model is stable and showing minimum distortion to the structure during the simulation period. Immunofluorescence and western-blotting studies indicate that MDAMB-231 cells stimulated with danazol exhibit translocation of PKCα to the plasma membrane...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933457/pristine-but-metal-rich-r%C3%A3-o-sucio-dirty-river-is-dominated-by-gallionella-and-other-iron-sulfur-oxidizing-microbes
#2
Alejandro Arce-Rodríguez, Fernando Puente-Sánchez, Roberto Avendaño, Eduardo Libby, Leonardo Rojas, Juan Carlos Cambronero, Dietmar H Pieper, Kenneth N Timmis, Max Chavarría
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes living within the geological formations is a subject of considerable controversy. Most microbiological studies of such waters have so far focused on acid mine drainage sites, which are heavily human-impacted environments, so it has been problematic to eliminate the human factor in the question of the origin of the key metal compounds...
December 8, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27933330/concentrations-of-arsenic-and-boron-in-water-sediment-and-the-tissues-of-fish-in-emet-stream-turkey
#3
Semra Benzer
In this study, the concentrations of arsenic and boron were determined in the water and the sediment, as well as in the muscle tissues of Squalius cephalus, Alburnoides bipunctatus, Barbus plebejus and Capoeta tinca from Emet Stream. The fish samples were caught in May 2011 and September 2012. The metal concentrations in the water samples were as follows: arsenic was 137.1-1002 µg L(-1), and boron was 2421-14490 µg L(-1). The metal concentrations in the sediment samples were as follows: arsenic was 14...
December 8, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27933238/high-particulate-matter-emission-from-additive-free-natural-american-spirit-cigarettes
#4
Yvonne Iffland, Ruth Müller, David Groneberg, Alexander Gerber
BACKGROUND: Involuntary exposure to health-threatening environmental tobacco smoke (Combined Mainstream and Side-stream Smoke, CMSS) is a worldwide problem, causing premature death of thousands of people. CMSS consists of particulate matter (PM), one of the main sources of indoor air pollution. PM constitutes a considerable health risk for passive smokers. It is important to inform the public about brand-specific differences in CMSS-associated PM, especially in the case of brands without additives, which are therefore promoted as natural and less health-threatening...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933146/operationalising-the-lean-principles-in-maternity-service-design-using-3p-methodology
#5
Iain Smith
The last half century has seen significant changes to Maternity services in England. Though rates of maternal and infant mortality have fallen to very low levels, this has been achieved largely through hospital admission. It has been argued that maternity services may have become over-medicalised and service users have expressed a preference for more personalised care. NHS England's national strategy sets out a vision for a modern maternity service that continues to deliver safe care whilst also adopting the principles of personalisation...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27932932/atlas-of-ohio-aquatic-insects-volume-ii-plecoptera
#6
R Edward DeWalt, Scott A Grubbs, Brian J Armitage, Richard W Baumann, Shawn M Clark, Michael J Bolton
BACKGROUND: We provide volume II of a distributional atlas of aquatic insects for the eastern USA state of Ohio. This treatment of stoneflies (Plecoptera) is companion to Armitage et al. (2011) on caddisflies (Trichoptera). We build on a recent analysis of Ohio stonefly diversity patterns based on large drainages (DeWalt et al. 2012), but add 3717 new records to the data set. We base most analyses on the United States Geological Survey Hierarchical Unit Code eight (HUC8) drainage scale...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27931998/-between-combat-boots-and-birkenstocks-lessons-from-hiv-aids-sars-h1n1-and-ebola
#7
R Crawford, D C Rutz, D P Evans
OBJECTIVES: In late 2013, an Ebola outbreak quickly grew into an epidemic of extraordinary magnitude, killing more people than all previous Ebola outbreaks combined. Although the epidemic was unprecedented, the world had previously experienced several acute public health emergencies requiring global coordination. HIV/AIDS, SARS and H1N1 tested global response, and in each case coordination proved problematic, making the 2013-2015 Ebola epidemic no exception. The purpose of this project was to identify persistent vulnerabilities within global public health emergency response and to identify areas for future research and improvement...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931993/age-period-cohort-analyses-of-obesity-prevalence-in-us-adults
#8
R An, X Xiang
OBJECTIVES: Age-period-cohort analysis is a stream of methodologies that decompose the temporal trends for disease risk into three time scales-age, calendar year (period) and year of birth (cohort). This study conducted age-period-cohort analyses of obesity prevalence in US adults. STUDY DESIGN: Retrospective data analysis. METHODS: We constructed regression models based on anthropometric data from the 1999-2012 National Health and Nutrition Examination Survey to correct for the self-reported height/weight in the 1984-2014 Behavioral Risk Factor Surveillance System (BRFSS)...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931923/assessing-the-sensitivity-of-european-surveillance-for-detecting-bse-in-cattle-according-to-international-standards
#9
Amie Adkin, Robin Simons, Mark Arnold
European surveillance for Bovine Spongiform Encephalopathy (BSE), initiated in 2001, has shown a steady exponential decline in the number of infected cattle, demonstrating that control measures have been effective. In 2016 23 European countries out of 28 demonstrated negligible risk status for the disease. The international standard setting body, the World Organization for Animal Health (OIE), prescribes that for countries where there is a non-negligible BSE risk, surveillance should allow the detection of one case per 100,000 in the adult cattle population with 95% confidence (Type A surveillance)...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27931383/stream-lake-and-reservoir-management
#10
Ying Mei, Chein-Chi Chang, Zhanfeng Dong, Li Wei
This review on stream, lake, and reservoir management covers selected 2015 publications on the focus of the following sections: Biota Climate effect Models Remediation and restoration Reservoir operations Stream, Lake, and Reservoir Management Water quality.
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27931165/improvement-of-municipal-wastewater-pretreatment-by-direct-membrane-filtration
#11
Thiago A Nascimento, Fanny R Mejía, Fernando Fdz-Polanco, Mar Peña Miranda
The high content of particulate matter in municipal wastewater hinders the conventional anaerobic treatments at psychrophilic temperatures. The hydrolysis of the particulate chemical oxygen demand (pCOD) could be the limiting step under these conditions. Therefore, new pretreatments or improved conventional pretreatments are needed in order to separate pCOD. In this work, direct membrane filtration of municipal wastewater, using an ultrafiltration membrane, was investigated. This intensive pretreatment, which aims to separate soluble chemical oxygen demand (sCOD) and to concentrate pCOD, together with anaerobic treatments of both streams at psychrophilic and mesophilic conditions respectively, could be an alternative to the conventional activated sludge process...
December 8, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27930851/surfactant-free-fabrication-of-fullerene-c60-nanotubules-under-shear
#12
Kasturi Vimalanathan, Rekha Goswami Shrestha, Zhi Zhang, Jin Zou, Tomonobu Nakayama, Colin L Raston
A method for controlling the self-assembly of fullerene C60 molecules into nanotubules in the fcc phase, devoid of entrapped solvent, has been established in a thin film microfluidic device. The micron length C60 nanotubules, with individual hollow diameters of 100 to 400 nm, are formed under continuous flow processing during high shear micromixing of water and a toluene solution of the fullerene, in the absence of surfactant, and without the need for further down-stream processing. TEM revealed pores on the surface of the nanotubes, and the isolated material has a much higher response to small molecule sensing than that for analogous material formed using multistep batch processing...
December 8, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27930672/brain-connectivity-variation-topography-associated-with-working-memory
#13
Xiaofei Ma, Xiaolin Huang, Yun Ge, Yueming Hu, Wei Chen, Aili Liu, Hongxing Liu, Ying Chen, Bin Li, Xinbao Ning
Brain connectivity analysis plays an essential role in the research of working memory that involves complex coordination of various brain regions. In this research, we present a comprehensive view of trans-states brain connectivity variation based on continuous scalp EEG, extending beyond traditional stimuli-lock averaging or restriction to short time scales of hundreds of milliseconds after stimulus onset. The scalp EEG was collected under three conditions: quiet, memory, and control. The only difference between the memory and control conditions was that in the memory condition, subjects made an effort to retain information...
2016: PloS One
https://www.readbyqxmd.com/read/27930317/impact-of-the-syrian-refugee-crisis-on-land-use-and-transboundary-freshwater-resources
#14
Marc François Müller, Jim Yoon, Steven M Gorelick, Nicolas Avisse, Amaury Tilmant
Since 2013, hundreds of thousands of refugees have migrated southward to Jordan to escape the Syrian civil war that began in mid-2011. Evaluating impacts of conflict and migration on land use and transboundary water resources in an active war zone remains a challenge. However, spatial and statistical analyses of satellite imagery for the recent period of Syrian refugee mass migration provide evidence of rapid changes in land use, water use, and water management in the Yarmouk-Jordan river watershed shared by Syria, Jordan, and Israel...
December 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27929735/development-of-adsorptive-hybrid-filters-to-enable-two-step-purification-of-biologics
#15
Nripen Singh, Abhiram Arunkumar, Michael Peck, Alexei M Voloshin, Angela M Moreno, Zhijun Tan, Jonathan Hester, Michael C Borys, Zheng Jian Li
Recent progress in mammalian cell culture process has resulted in significantly increased product titers, but also a substantial increase in process- and product-related impurities. Due to the diverse physicochemical properties of these impurities, there is constant need for new technologies that offer higher productivity and improved economics without sacrificing the process robustness required to meet final drug substance specifications. Here, we examined the use of new synthetic adsorptive hybrid filters (AHF) modified with the high binding capacity of quaternary amine (Emphaze™ AEX) and salt-tolerant biomimetic (Emphaze™ ST-AEX) ligands for clearance of process-related impurities like host cell protein (HCP), residual DNA, and virus...
December 8, 2016: MAbs
https://www.readbyqxmd.com/read/27929096/enhancing-steel-properties-through-in-situ-formation-of-ultrahard-ceramic-surface
#16
Farshid Pahlevani, Rahul Kumar, Narjes Gorjizadeh, Rumana Hossain, Sagar T Cholake, Karen Privat, Veena Sahajwalla
Abrasion and corrosion resistant steel has attracted considerable interest for industrial application as a means of minimising the costs associated with product/component failures and/or short replacement cycles. These classes of steels contain alloying elements that increase their resistance to abrasion and corrosion. Their benefits, however, currently come at a potentially prohibitive cost; such high performance steel products are both more technically challenging and more expensive to produce. Although these methods have proven effective in improving the performance of more expensive, high-grade steel components, they are not economically viable for relatively low cost steel products...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928980/inside-doctor-livingstone-a-scottish-icon-s-encounter-with-tropical-disease
#17
Michael P Barrett, Federica Giordani
Dr David Livingstone died on May 1st 1873. He was 60 years old and had spent much of the previous 30 years walking across large stretches of Southern Africa, exploring the terrain he hoped could provide new environments in which Europeans and Africans could cohabit on equal terms and bring prosperity to a part of the world he saw ravaged by the slave trade. Just days before he died, he wrote in his journal about the permanent stream of blood that he was emitting related to haemorrhoids and the acute intestinal pain that had left him incapable of walking...
December 8, 2016: Parasitology
https://www.readbyqxmd.com/read/27928585/characterizing-the-effects-of-stormwater-mitigation-on-nutrient-export-and-stream-concentrations
#18
Colin D Bell, Sara K McMillan, Sandra M Clinton, Anne J Jefferson
Urbanization increases nutrient loading and lowers residence times for processing of reactive solutes, including nitrate, total dissolved nitrogen, orthophosphate, and dissolved organic carbon), which leads to increased stream concentrations and mass export. Stormwater control measures mitigate the impacts of urbanization, and have the potential to improve stream water quality, however the net effect instream is not well understood. We monitored two urban and two suburban watersheds in Charlotte, NC to determine if mitigation controlled the fraction of total mass export during storm, if development classification as either urban or suburban (defined by the age, density and distribution of urban development) controlled storm nutrient and carbon dynamics, and if stormwater control measures were able to change stream water chemistry...
December 8, 2016: Environmental Management
https://www.readbyqxmd.com/read/27928444/the-remote-effects-of-intravitreal-anti-vegf-therapy
#19
Balta F, Merticariu M, Taban C, Neculau G, Merticariu A, Muresanu D, Badescu D, Jinga V
Objective: To study the effects of intravitreal anti-Vascular Endothelial Growth Factor (VEGF) therapy with Avastin for wet Age-Related Macular Degeneration (AMD) on Benign Prostatic Hyperplasia (BPH)-related symptoms. Methods: An exploratory trial was conducted from August 1, 2013 to February 1, 2014, that included 14 male patients previously diagnosed with BPH, who were aged between 59 and 69 years. The trial was performed in Bucharest and involved two medical institutions: the Clinical Hospital of Eye Emergencies and the "Prof...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27924323/the-use-of-a-quartz-crystal-microbalance-as-an-analytical-tool-to-monitor-particle-surface-and-particle-particle-interactions-under-dry-ambient-and-pressurized-conditions-a-study-using-common-inhaler-components
#20
N W Turner, M Bloxham, S A Piletsky, M J Whitcombe, I Chianella
Metered dose inhalers (MDI) and multidose powder inhalers (MPDI) are commonly used for the treatment of chronic obstructive pulmonary diseases and asthma. Currently, analytical tools to monitor particle/particle and particle/surface interaction within MDI and MPDI at the macro-scale do not exist. A simple tool capable of measuring such interactions would ultimately enable quality control of MDI and MDPI, producing remarkable benefits for the pharmaceutical industry and the users of inhalers. In this paper, we have investigated whether a quartz crystal microbalance (QCM) could become such a tool...
December 7, 2016: Analyst
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