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https://www.readbyqxmd.com/read/29166605/l-type-voltage-gated-ca-2-channels-regulate-synaptic-activity-triggered-recycling-endosome-fusion-in-neuronal-dendrites
#1
Brian G Hiester, Ashley M Bourke, Brooke L Sinnen, Sarah G Cook, Emily S Gibson, Katharine R Smith, Matthew J Kennedy
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity, how synaptic activity drives RE fusion remains unexplored. We demonstrate a multistep fusion mechanism that requires Ca(2+) from distinct sources. NMDA receptor Ca(2+) initiates RE fusion with the plasma membrane, while L-type voltage-gated Ca(2+) channels (L-VGCCs) regulate whether fused REs collapse into the membrane or reform without transferring their cargo to the cell surface...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166591/a-cd103-conventional-dendritic-cell-surveillance-system-prevents-development-of-overt-heart-failure-during-subclinical-viral-myocarditis
#2
Xavier Clemente-Casares, Siyavash Hosseinzadeh, Iulia Barbu, Sarah A Dick, Jillian A Macklin, Yiming Wang, Abdul Momen, Crystal Kantores, Laura Aronoff, Maylis Farno, Tiffany M Lucas, Joan Avery, Dorrin Zarrin-Khat, Heidi J Elsaesser, Babak Razani, Kory J Lavine, Mansoor Husain, David G Brooks, Clinton S Robbins, Myron Cybulsky, Slava Epelman
Innate and adaptive immune cells modulate heart failure pathogenesis during viral myocarditis, yet their identities and functions remain poorly defined. We utilized a combination of genetic fate mapping, parabiotic, transcriptional, and functional analyses and demonstrated that the heart contained two major conventional dendritic cell (cDC) subsets, CD103(+) and CD11b(+), which differentially relied on local proliferation and precursor recruitment to maintain their tissue residency. Following viral infection of the myocardium, cDCs accumulated in the heart coincident with monocyte infiltration and loss of resident reparative embryonic-derived cardiac macrophages...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166292/concussion-in-theater-a-cross-sectional-survey-of-prevalence-and-management-in-actors-and-theater-technicians
#3
Jeffrey A Russell, Brooke M Daniell
OBJECTIVE: Determine the history of occupational head impacts, concussion symptoms, and concussion management in theater personnel. METHODS: Personnel working in theater environments completed a survey about head impacts that occurred in theater activities and how they were managed. RESULTS: Lifetime prevalence of sustaining at least one theater-related head impact was 67%. Thirty-nine percent of respondents reported more than 5 lifetime head impacts; 77% reported 3 or more...
November 21, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29166238/shiga-toxin-producing-e-coli-infections-associated-with-flour
#4
Samuel J Crowe, Lyndsay Bottichio, Lauren N Shade, Brooke M Whitney, Nereida Corral, Beth Melius, Katherine D Arends, Danielle Donovan, Jolianne Stone, Krisandra Allen, Jessica Rosner, Jennifer Beal, Laura Whitlock, Anna Blackstock, June Wetherington, Lisa A Newberry, Morgan N Schroeder, Darlene Wagner, Eija Trees, Stelios Viazis, Matthew E Wise, Karen P Neil
Background In 2016, a multijurisdictional team investigated an outbreak of Shiga toxin-producing Escherichia coli (STEC) serogroup O121 and O26 infections linked to contaminated flour from a large domestic producer. Methods A case was defined as infection with an outbreak strain in which illness onset was between December 21, 2015, and September 5, 2016. To identify exposures associated with the outbreak, outbreak cases were compared with non-STEC enteric illness cases, matched according to age group, sex, and state of residence...
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29165458/the-effect-of-structural-modifications-on-the-thermal-stability-melting-points-and-ion-interactions-for-a-series-of-tetraaryl-phosphonium-based-mesothermal-ionic-liquids
#5
Cody A Cassity, Benjamin Siu, Mohammad Soltani, Jimmy L McGeehee, Katie J Strickland, Matt Vo, E Alan Salter, Alexandra C Stenson, Andrzej Wierzbicki, Kevin N West, Brooks D Rabideau, James H Davis
A family of mesothermal ionic liquids comprised of tetraarylphosphonium cations and the bis(trifluoromethanesulfonyl)amidate anion are shown to be materials of exceptional thermal stability, enduring (without decomposition) heating in air at 300 °C for three months. It is further established that three specific structural elements - phenoxy, phenacyl, and phenyl sulfonyl - can be present in the cation structures without compromising their thermal stability, and that their incorporation has specific impacts on the melting points of the salts...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29164209/tuning-the-cytotoxicity-of-ruthenium-ii-para-cymene-complexes-by-mono-substitution-at-a-triphenylphosphine-phenoxydiphenylphosphine-ligand
#6
Lorenzo Biancalana, Stefano Zacchini, Nicola Ferri, Maria Giovanna Lupo, Guido Pampaloni, Fabio Marchetti
The new complexes [RuCl2(η(6)-p-cymene)(κP-Ph2PR)] [R = 4-C6H4OSiMe2(t)Bu, 1; R = 4-C6H4Br, 2; R = OC([double bond, length as m-dash]O)CHCl2, 3; R = OPh, 4; R = O(2-C6H4SiMe2(t)Bu), 5] and [Ru(C2O4)(η(6)-p-cymene){κP-Ph2PO(2-C6H4(SiMe2(t)Bu))}], 6, were obtained in 83-98% yield from Ru(ii) arene precursors by three different synthetic strategies. The unprecedented phosphine Ph2P(O(2-C6H4SiMe2(t)Bu)) was synthesized in 86% yield from 2-C6H4Br(OSiMe2(t)Bu) and Ph2PCl, via intramolecular oxygen to carbon 1,3 migration of the silyl group (retro-Brook rearrangement)...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29163980/follow-up-monitoring-in-a-cat-with-leishmaniosis-and-coinfections-with-hepatozoon-felis-and-candidatus-mycoplasma-haemominutum
#7
Charalampos Attipa, Kyriaki Neofytou, Christos Yiapanis, Pamela Martínez-Orellana, Gad Baneth, Yaarit Nachum-Biala, Harriet Brooks-Brownlie, Laia Solano-Gallego, Séverine Tasker
Case summary: A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hepatozoon species and 'Candidatus Mycoplasma haemominutum' (CMhm) DNA. Subsequent sequencing identified Hepatozoon felis...
July 2017: JFMS open reports
https://www.readbyqxmd.com/read/29163147/chronic-psychological-stress-was-not-ameliorated-by-omega-3-eicosapentaenoic-acid-epa
#8
Joanne Bradbury, Stephen P Myers, Barbara Meyer, Lyndon Brooks, Jonathan Peake, Andrew J Sinclair, Con Stough
Background: Chronic psychological stress and mental health disorders are endemic in Western culture where population dietary insufficiencies of omega-3 fatty acids (n-3FA) from seafood have been observed. Objective: This study was designed to test for a causal relationship between one of the most active components of fish oil, eicosapentaenoic acid (EPA), and chronic psychological stress. Method: A randomized double-blind, placebo-controlled clinical trial with parallel-assignment to two groups was designed (Trial Id: ACTRN12610000404022)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162910/a-library-of-chemically-defined-human-n-glycans-synthesized-from-microbial-oligosaccharide-precursors
#9
Brian S Hamilton, Joshua D Wilson, Marina A Shumakovich, Adam C Fisher, James C Brooks, Alyssa Pontes, Radnaa Naran, Christian Heiss, Chao Gao, Robert Kardish, Jamie Heimburg-Molinaro, Parastoo Azadi, Richard D Cummings, Judith H Merritt, Matthew P DeLisa
Synthesis of homogenous glycans in quantitative yields represents a major bottleneck to the production of molecular tools for glycoscience, such as glycan microarrays, affinity resins, and reference standards. Here, we describe a combined biological/enzymatic synthesis that is capable of efficiently converting microbially-derived precursor oligosaccharides into structurally uniform human-type N-glycans. Unlike starting material obtained by chemical synthesis or direct isolation from natural sources, which can be time consuming and costly to generate, our approach involves precursors derived from renewable sources including wild-type Saccharomyces cerevisiae glycoproteins and lipid-linked oligosaccharides from glycoengineered Escherichia coli...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162724/progesterone-receptor-a-promotes-invasiveness-and-metastasis-of-luminal-breast-cancer-by-suppressing-regulation-of-critical-micro-rnas-by-estrogen
#10
Thomas McFall, Brooke McKnight, Rayna Rosati, Seongho Kim, Yanfang Huang, Nerissa Viola-Villegas, Manohar Ratnam
Distal metastasis of luminal breast cancer is frequent and incurable, yet the metastasis mechanisms are poorly understood. Estrogen, even at postmenopausal concentrations, suppresses invasiveness of luminal breast cancer cells through the estrogen receptor (ER). Invasive tumors overexpress the short progesterone receptor A (PR-A) isoform. Even at postmenopausal concentrations, progesterone activates PR-A, inducing invasiveness by counteracting estrogens effects, particularly when cells are hyper-sensitized to progesterone by PR-A overexpression...
November 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29162688/differential-effects-of-global-and-local-climate-data-in-assessing-environmental-drivers-of-epidemic-outbreaks
#11
Timothy Brook
No abstract text is available yet for this article.
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29161526/individualism-collectivism-social-self-control-and-adolescent-substance-use-and-risky-sexual-behavior
#12
Pallav Pokhrel, Brooke L Bennett, Sakshi Regmi, Bulat Idrisov, Artur Galimov, Leila Akhmadeeva, Steve Sussman
Individualism and collectivism are cultural syndromes that have been associated with adolescent problem behavior in studies conducted in the U.S. and Southeast Asia. However, research investigating the mechanisms of how cultural orientation impacts health risk behaviors has been limited. This study tested a new model explaining the relationship between cultural orientation (i.e., individualism, collectivism) and adolescent problem behavior (i.e., substance use and risky sex) in terms of interpersonal self-regulation (i...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29160742/university-affiliated-alcohol-marketing-enhances-the-incentive-salience-of-alcohol-cues
#13
Bruce D Bartholow, Chris Loersch, Tiffany A Ito, Meredith P Levsen, Hannah I Volpert-Esmond, Kimberly A Fleming, Paul Bolls, Brooke K Carter
We tested whether affiliating beer brands with universities enhances the incentive salience of those brands for underage drinkers. In Study 1, 128 undergraduates viewed beer cues while event-related potentials (ERPs) were recorded. Results showed that beer cues paired with in-group backgrounds (logos for students' universities) evoked an enhanced P3 ERP component, a neural index of incentive salience. This effect varied according to students' levels of identification with their university, and the amplitude of the P3 response prospectively predicted alcohol use over 1 month...
November 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29160217/morphological-and-molecular-confirmation-of-myxobolus-cerebralis-myxospores-infecting-wild%C3%A2-caught-and-cultured-trout-in-north-carolina-se-usa
#14
Carlos F Ruiz, Jacob M Rash, Cova R Arias, Doug A Besler, Raphael Orélis-Ribeiro, Matthew R Womble, Jackson R Roberts, Micah B Warren, Candis L Ray, Stacey Lafrentz, Stephen A Bullard
We used microscopy and molecular biology to provide the first documentation of infections of Myxobolus cerebralis (Myxozoa: Myxobolidae), the etiological agent of whirling disease, in trout (Salmonidae) from North Carolina (USA) river basins. A total of 1085 rainbow trout Oncorhynchus mykiss, 696 brown trout Salmo trutta, and 319 brook trout Salvelinus fontinalis from 43 localities across 9 river basins were screened. Myxospores were observed microscopically in pepsin-trypsin digested heads of rainbow and brown trout from the Watauga River Basin...
November 21, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29160031/maternal-inheritance-of-bdnf-deletion-with-phenotype-of-obesity-and-developmental-delay-in-mother-and-child
#15
Brooke E Harcourt, Denise V R Bullen, Kung-Ting Kao, Daniella Tassoni, Erin J Alexander, Trent Burgess, Susan M White, Matthew A Sabin
Childhood obesity is a significant world health problem. Understanding the genetic and environmental factors contributing to the development of obesity in childhood is important for the rational design of strategies for obesity prevention and treatment. Brain-derived neurotrophic factor (BDNF) plays an important role in the growth and development of the central nervous system, there is also an evidence that BDNF plays a role in regulation of appetite. Disruption of the expression of this gene in a child has been previously reported to result in a phenotype of severe obesity, hyperphagia, impaired cognitive function, and hyperactivity...
November 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29159677/not-all-sagittal-band-tears-come-with-extensor-instability-a-case-report-with-radiological-and-operative-correlation
#16
Shuo Li, Jeffrey J Brooks, Jubin Jacob, Ahmadreza Ghasemiesfe, Greg B Marrinan
The sagittal bands are a component of the extensor hood. They serve an important role in stabilizing the extensor tendon by forming a "check-rein" to radial-ulnar translation of the tendon over the metacarpal head, and extending the metacarpophalangeal (MCP) joint by virtue of attaching the extensor tendon to the palmar plate. Injury to the sagittal band is thought to cause extensor instability and subluxation to the contralateral side by disruption of this "check-rein" function, although recent evidence from cadaver studies suggests that ulnar sagittal band tear may be spared of extensor instability...
November 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29158318/cisplatin-induces-the-release-of-extracellular-vesicles-from-ovarian-cancer-cells-that-can-induce-invasiveness-and-drug-resistance-in-bystander-cells
#17
Priya Samuel, Laura Ann Mulcahy, Fiona Furlong, Helen O McCarthy, Susan Ann Brooks, Muller Fabbri, Ryan Charles Pink, David Raul Francisco Carter
Ovarian cancer has a poor overall survival that is partly caused by resistance to drugs such as cisplatin. Resistance can be acquired as a result of changes to the tumour or due to altered interactions within the tumour microenvironment. Extracellular vesicles (EVs), small lipid-bound vesicles that are loaded with macromolecular cargo and released by cells, are emerging as mediators of communication in the tumour microenvironment. We previously showed that EVs mediate the bystander effect, a phenomenon in which stressed cells can communicate with neighbouring naive cells leading to various effects including DNA damage; however, the role of EVs released following cisplatin treatment has not been tested...
January 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29158264/azole-resistance-in-a-candida-albicans-mutant-lacking-the-abc-transporter-cdr6-roa1-depends-on-tor-signaling
#18
Nitesh Kumar Khandelwal, Neeraj Chauhan, Parijat Sarkar, Brooke D Esquivel, Paola Coccetti, Ashutosh Singh, Alix T Coste, Meghna Gupta, Dominique Sanglard, Theodore C White, Murielle Chauvel, Christophe dEnfert, Amitabha Chattopadhyay, Naseem A Gaur, Alok Kumar Mondal, Rajendra Prasad
ATP-binding cassette (ABC) transporters help export various substrates across the cell membrane and significantly contribute to drug resistance. However, a recent study reported an unusual case in which the loss of an ABC transporter in Candida albicans, orf19.4531 (previously named ROA1), increases resistance against antifungal azoles, which was attributed to an altered membrane potential in the mutant strain. To get further mechanistic insights into this phenomenon, here we confirmed that the plasma membrane localized transporter (renamed CDR6/ROA1 for consistency with C...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29158206/pulmonary-rehabilitation-with-balance-training-for-fall-reduction-in-chronic-obstructive-pulmonary-disease-protocol-for-a-randomized-controlled-trial
#19
Marla K Beauchamp, Dina Brooks, Cindy Ellerton, Annemarie Lee, Jennifer Alison, Pat G Camp, Gail Dechman, Kimberley Haines, Samantha L Harrison, Anne E Holland, Alda Marques, Rahim Moineddin, Elizabeth H Skinner, Lissa Spencer, Michael K Stickland, Feng Xie, Roger S Goldstein
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. A growing body of evidence shows that individuals with COPD have important deficits in balance control that may be associated with an increased risk of falls. Pulmonary rehabilitation (PR) is a key therapeutic intervention for individuals with COPD; however, current international guidelines do not include balance training and fall prevention strategies. OBJECTIVE: The primary aim of this trial is to determine the effects of PR with balance training compared to PR with no balance training on the 12-month rate of falls in individuals with COPD...
November 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29157570/building-clinical-education-training-capacity-in-nurse-practitioner-programs
#20
Shirlee M Drayton-Brooks, Paula A Gray, Nichole P Turner, Jamesetta A Newland
Building clinical education training capacity in nurse practitioner programs is critical to build the primary care workforce and to address the access to care problem in the country. Challenges related to obtaining clinical sites and qualified preceptors are well reported, but few practical solutions are presented. Clinical sites and qualified preceptors willing to serve can be found, but nurse practitioner faculty must remove obstacles and strengthen resources by discovering untapped capacity. Nurse practitioner faculty can design, implement, and test innovative clinical models to maximize clinical training capacity...
November 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
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