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https://www.readbyqxmd.com/read/28241273/miniature-spectral-imaging-device-for-wide-field-quantitative-functional-imaging-of-the-morphological-landscape-of-breast-tumor-margins
#1
Brandon S Nichols, Antonio Llopis, Gregory M Palmer, Samuel S McCachren, Ozlem Senlik, David Miller, Martin A Brooke, Nan M Jokerst, Joseph Geradts, Rachel Greenup, Nimmi Ramanujam
No abstract text is available yet for this article.
February 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28241232/the-global-threat-of-outdoor-ambient-air-pollution-to-cardiovascular-health-time-for-intervention
#2
Robert D Brook, David E Newby, Sanjay Rajagopalan
No abstract text is available yet for this article.
February 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28241115/robustness-of-land-use-regression-models-developed-from-mobile-air-pollutant-measurements
#3
Marianne Hatzopoulou, Marie-France Valois, Ilan Levy, Cristian Mihele, Gang Lu, Scott Bagg, Laura Minet, Jeffrey Robert Brook
Land-Use Regression (LUR) models are useful for resolving fine scale spatial variations in average air pollutant concentrations across urban areas. With the rise of mobile air pollution campaigns, characterized by short-term monitoring and large spatial extents, it is important to investigate the effects of sampling protocols on the resulting LUR. In this study a mobile lab was used to repeatedly visit a large number of locations (~1800), defined by road segments, to derive average concentrations across the city of Montreal, Canada...
February 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28240392/abnormal-task-driven-neural-oscillations-in-multiple-sclerosis-a-visuomotor-meg-study
#4
Eleanor L Barratt, Prejaas K Tewarie, Margareta A Clarke, Emma L Hall, Penny A Gowland, Peter G Morris, Susan T Francis, Nikos Evangelou, Matthew J Brookes
Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observed routinely in patients undergoing MRI scans, such measures are often a poor predictor of disease severity. For this reason, it is instructive to measure associated changes in brain function. Widespread white-matter demyelination may lead to delays of propagation of neuronal activity, and with its excellent temporal resolution, magnetoencephalography can be used to probe such delays in controlled conditions (e...
February 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28239865/effect-of-weight-and-frontal-area-of-external-telemetry-packages-on-the-kinematics-activity-levels-and-swimming-performance-of-small-bodied-sharks
#5
I A Bouyoucos, C D Suski, J W Mandelman, E J Brooks
This study sought to observe the effects of submerged weight and frontal cross-sectional area of external telemetry packages on the kinematics, activity levels and swimming performance of small-bodied juvenile sharks, using lemon sharks Negaprion brevirostris (60-80 cm total length, LT ) as a model species. Juveniles were observed free-swimming in a mesocosm untagged and with small and large external accelerometer packages that increased frontal cross-sectional area of the animals and their submerged weight...
February 27, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28239720/superwetting-comonomers-reduce-adhesion-of-e-coli-bl21
#6
Madiha F Khan, Nicholas Luong, Jerry Kurian, Michael A Brook
The adhesion of Escherichia coli to copolymers of methacrylates and a trisiloxane-polyether acrylate surfactant was found to be at a minimum with copolymers containing a low (20%) fraction of the surfactant monomer. Rather than wettability, hardness, or water uptake, adhesion was found to be limited by the presence of low concentrations of bound surfactant that can interact with hydrophobic domains on the bacterium inhibiting anchoring to the polymer surface.
February 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28239496/life-expectancy-in-pleural-and-peritoneal-mesothelioma
#7
Robert Shavelle, Kate Vavra-Musser, Jessica Lee, Jordan Brooks
Background. Mesothelioma is a rare cancer with a historically dire prognosis. We sought to calculate life expectancies for patients with pleural or peritoneal mesothelioma, both at time of diagnosis and several years later, and to examine whether survival has improved in recent years. Methods. Data on 10,258 pleural and 1,229 peritoneal patients from the SEER US national cancer database, 1973-2011, were analyzed using the Cox proportional hazards regression model. Results. The major factors related to survival were age, sex, stage, grade, histology, and treatment...
2017: Lung Cancer International
https://www.readbyqxmd.com/read/28239017/reducing-risky-sex-among-rural-african-american-cocaine-users-a-controlled-trial
#8
Katharine E Stewart, Patricia B Wright, Brooke E Montgomery, Donna Gullette, Leavonne Pulley, Songthip Ounpraseuth, Jeff Thostenson, Brenda Booth
Rural African American cocaine users experience high rates of STIs/HIV. This NIDA-funded trial tested an adapted evidence-based risk reduction program versus an active control condition. Participants were 251 African American cocaine users in rural Arkansas recruited from 2009-2011. Outcomes included condom use skills and self-efficacy, sexual negotiation skills, peer norms, and self-reported risk behavior. The intervention group experienced greater increases in condom use skills and overall effectiveness in sexual negotiation skills...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238938/estimating-direction-in-brain-behavior-interactions-proactive-and-reactive-brain-states-in-driving
#9
Javier O Garcia, Justin Brooks, Scott Kerick, Tony Johnson, Tim R Mullen, Jean M Vettel
Conventional neuroimaging analyses have ascribed function to particular brain regions, exploiting the power of the subtraction technique in fMRI and event-related potential analyses in EEG. Moving beyond this convention, many researchers have begun exploring network-based neurodynamics and coordination between brain regions as a function of behavioral parameters or environmental statistics; however, most approaches average evoked activity across the experimental session to study task-dependent networks. Here, we examined on-going oscillatory activity as measured with EEG and use a methodology to estimate directionality in brain-behavior interactions...
February 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28238832/the-energetic-physiological-and-behavioral-response-of-lemon-sharks-negaprion-brevirostris-to-simulated-longline-capture
#10
Ian A Bouyoucos, Cory D Suski, John W Mandelman, Edward J Brooks
Commercial fisheries bycatch is a considerable threat to elasmobranch population recovery, and techniques to mitigate sub-lethal consequences can be improved with data on the energetic, physiological, and behavioral response of individuals to capture. This study sought to estimate the effects of simulated longline capture on the behavior, energy use, and physiological stress of juvenile lemon sharks (Negaprion brevirostris). Captive sharks equipped with acceleration biologgers were subjected to one hour of simulated longline capture...
February 23, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28237951/subretinal-abscess
#11
Brook Pittenger, Jonathan W Young, André Martin Mansoor
No abstract text is available yet for this article.
February 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28236961/a-year-of-myplate-mywins-small-changes-add-up-to-big-wins-help-put-your-best-fork-forward
#12
Kristen Booze, Brooke Hardison, Jackie Haven
No abstract text is available yet for this article.
March 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28235898/gabaergic-neurons-of-the-central-amygdala-promote-cataplexy
#13
Carrie E Mahoney, Lindsay J Agostinelli, Jessica N K Brooks, Bradford B Lowell, Thomas E Scammell
Narcolepsy is characterized by chronic sleepiness and cataplexy - sudden muscle paralysis triggered by strong, positive emotions. Narcolepsy is caused by a lack of orexin (hypocretin) signaling, but little is known about the neural mechanisms that mediate cataplexy. The amygdala regulates responses to rewarding stimuli and contains neurons active during cataplexy. In addition, lesions of the amygdala reduce cataplexy. As GABAergic neurons of the central nucleus of the amygdala (CeA) target brainstem regions known to regulate muscle tone, we hypothesized that these cells promote emotion-triggered cataplexy...
February 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28235860/active-shortening-protects-against-stretch-induced-force-deficits-in-human-skeletal-muscle
#14
Anjali L Saripalli, Kristoffer B Sugg, Christopher L Mendias, Susan V Brooks, Dennis R Claflin
Skeletal muscle contraction results from molecular interactions of myosin "crossbridges" with adjacent actin filament binding sites. The binding of myosin to actin can be "weak" or "strong", and only strong binding states contribute to force production. During active shortening, the number of strongly-bound crossbridges declines with increasing shortening velocity. Forcibly stretching a muscle that is actively shortening at high velocity results in no apparent negative consequences whereas stretch of an isometrically (fixed-length) contracting muscle causes ultrastructural damage and a decline in force-generating capability...
February 23, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28235659/suspected-non-alzheimer-s-pathology-is-it-non-alzheimer-s-or-non-amyloid
#15
REVIEW
M Dani, D J Brooks, P Edison
Neurodegeneration, the progressive loss of neurons, is a major process involved in dementia and age-related cognitive impairment. It can be detected clinically using currently available biomarker tests. Suspected Non Alzheimer Pathology (SNAP) is a biomarker-based concept that encompasses a group of individuals with neurodegeneration, but no evidence of amyloid deposition (thereby distinguishing it from Alzheimer's disease (AD)). These individuals may often have a clinical diagnosis of AD, but their clinical features, genetic susceptibility and progression can differ significantly, carrying crucial implications for precise diagnostics, clinical management, and efficacy of clinical drug trials...
February 21, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28235438/practical-approaches-to-evaluating-progress-and-outcomes-in-community-wide-teen-pregnancy-prevention-initiatives
#16
REVIEW
Heather D Tevendale, D Susanne Condron, Lucas Godoy Garraza, L Duane House, Lisa M Romero, Megan A M Brooks, Christine Walrath
This paper presents an overview of the key evaluation components for a set of community-wide teen pregnancy prevention initiatives. We first describe the performance measures selected to assess progress toward meeting short-term objectives on the reach and quality of implementation of evidence-based teen pregnancy prevention interventions and adolescent reproductive health services. Next, we describe an evaluation that will compare teen birth rates in intervention communities relative to synthetic control communities...
March 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28235428/validation-of-a-hand-held-point-of-care-device-for-lactate-in-adult-and-pediatric-patients-using-traditional-and-locally-smoothed-median-and-maximum-absolute-difference-curves
#17
Jessica Marie Colon-Franco, Stanley F Lo, Sergey S Tarima, David Gourlay, Amy L Drendel, E Brook Lerner
BACKGROUND: Lactate is commonly used in septic patients and is a viable biomarker for trauma patients. Its pre-hospital use could assist triaging and managing patients with these conditions. METHODS: We evaluated the analytical performance of the point-of-care (POC) StatStrip Xpress Lactate Meter (Nova Biomedical) and compared it to the ABL 800 (Radiometer). We measured lactate in 250 adult and 250 pediatric whole blood samples in 2 laboratories. The performance of the POC meter was assessed by traditional linear regression and Bland-Altman plots, and locally-smoothed (LS) median absolute difference and maximum absolute difference (MAD and MaxAD) curves...
February 21, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28231242/predicting-ebola-infection-a-malaria-sensitive-triage-score-for-ebola-virus-disease
#18
Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi
BACKGROUND: The non-specific symptoms of Ebola Virus Disease (EVD) pose a major problem to triage and isolation efforts at Ebola Treatment Centres (ETCs). Under the current triage protocol, half the patients allocated to high-risk "probable" wards were EVD(-): a misclassification speculated to predispose nosocomial EVD infection. A better understanding of the statistical relevance of individual triage symptoms is essential in resource-poor settings where rapid, laboratory-confirmed diagnostics are often unavailable...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28230051/cellular-senescence-mediates-fibrotic-pulmonary-disease
#19
Marissa J Schafer, Thomas A White, Koji Iijima, Andrew J Haak, Giovanni Ligresti, Elizabeth J Atkinson, Ann L Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L Mazula, Robert W Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y S Prakash, Tamara Tchkonia, Paul D Robbins, Marie Christine Aubry, João F Passos, James L Kirkland, Daniel J Tschumperlin, Hirohito Kita, Nathan K LeBrasseur
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasing with disease severity...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28228488/uk-guideline-on-transition-of-adolescent-and-young-persons-with-chronic-digestive-diseases-from-paediatric-to-adult-care
#20
Alenka J Brooks, Philip J Smith, Richard Cohen, Paul Collins, Andrew Douds, Valda Forbes, Daniel R Gaya, Brian T Johnston, Patrick J McKiernan, Charles D Murray, Shaji Sebastian, Monica Smith, Lisa Whitley, Lesley Williams, Richard K Russell, Sara A McCartney, James O Lindsay
The risks of poor transition include delayed and inappropriate transfer that can result in disengagement with healthcare. Structured transition care can improve control of chronic digestive diseases and long-term health-related outcomes. These are the first nationally developed guidelines on the transition of adolescent and young persons (AYP) with chronic digestive diseases from paediatric to adult care. They were commissioned by the Clinical Services and Standards Committee of the British Society of Gastroenterology under the auspices of the Adolescent and Young Persons (A&YP) Section...
February 21, 2017: Gut
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