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https://www.readbyqxmd.com/read/28812670/moment-of-truth-for-the-cerrado-hotspot
#1
Bernardo B N Strassburg, Thomas Brooks, Rafael Feltran-Barbieri, Alvaro Iribarrem, Renato Crouzeilles, Rafael Loyola, Agnieszka E Latawiec, Francisco J B Oliveira Filho, Carlos A de M Scaramuzza, Fabio R Scarano, Britaldo Soares-Filho, Andrew Balmford
No abstract text is available yet for this article.
March 23, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812595/compulsive-like-sufentanil-vapor-self-administration-in-the-rat
#2
Janaina Cm Vendruscolo, Brendan J Tunstall, Stephanie A Carmack, Brooke E Schmeichel, Emily G Lowery-Gionta, Maury Cole, Olivier George, Sophia Vandewater, Michael Taffe, George F Koob, Leandro F Vendruscolo
Opioid misuse is at historically high levels in the United States, with inhalation (ie, smoking, and vaping) being one of the most common routes of consumption. We developed and validated a novel preclinical model of opioid self-administration by inhalation that does not require surgery and reliably produces somatic and motivational signs of dependence. Rats were trained to perform an operant response (nosepoke) to receive 10 s of vaporized sufentanil, a potent opioid, in 2 h daily sessions. Rats readily and concentration-dependently self-administered vaporized sufentanil...
August 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28812036/incidence-of-sports-related-concussion-among-ncaa-women-s-ice-hockey-athletes
#3
Emily M Brook, Emily Kroshus, Caroline H Hu, Marissa Gedman, Jamie E Collins, Elizabeth G Matzkin
BACKGROUND: There are limited data on the incidence of concussion and concussion symptom nondisclosure among collegiate women's ice hockey athletes. PURPOSE: To determine the incidence of sports-related concussion (SRC) in National Collegiate Athletic Association (NCAA) women's ice hockey athletes. STUDY DESIGN: Descriptive epidemiology study. METHODS: An anonymous online survey was completed by 459 NCAA women's ice hockey athletes...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28811738/predictors-of-retention-among-african-americans-in-a-randomized-controlled-trial-to-test-the-healthy-eating-and-active-living-in-the-spirit-heals-intervention
#4
Oluwole A Babatunde, Swann Arp Adams, Michael D Wirth, Jan M Eberth, Jameson Sofge, Seul Ki Choi, Brook E Harmon, Lisa Davis, Ruby Drayton, Thomas G Hurley, Heather M Brandt, Cheryl A Armstead, James R Hébert
INTRODUCTION: Retention of racial/ethnic minority groups into research trials is necessary to fully understand and address health disparities. This study was conducted to identify participants' characteristics associated with retention of African Americans (AAs) in a randomized controlled trial (RCT) of a behavioral intervention. METHODS: Using data from an RCT conducted from 2009 to 2012 among AAs, participant-level factors were examined for associations with retention between three measurement points (ie, baseline, 3-month, and 12-month)...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28811379/geography-of-intergenerational-mobility-and-child-development
#5
Louis Donnelly, Irwin Garfinkel, Jeanne Brooks-Gunn, Brandon G Wagner, Sarah James, Sara McLanahan
Recent research by Chetty and colleagues finds that children's chances of upward mobility are affected by the communities in which they grow up [Chetty R, Hendren N (2016) Working paper 23002]. However, the developmental pathways through which communities of origin translate into future economic gain are not well understood. In this paper we examine the association between Chetty and Hendren's county-level measure of intergenerational mobility and children's cognitive and behavioral development. Focusing on children from low-income families, we find that growing up in a county with high upward mobility is associated with fewer externalizing behavioral problems by age 3 years and with substantial gains in cognitive test scores between ages 3 and 9 years...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28811296/a-novel-d2o-tracer-method-to-quantify-rna-turnover-as-a-biomarker-of-de-novo-ribosomal-biogenesis-in-vitro-in-animal-models-and-in-human-skeletal-muscle
#6
Matthew S Brook, Daniel J Wilkinson, W Kyle Mitchell, Jonathan L Lund, Bethan E Phillips, Nathaniel J Sweczyk, Heikki Kainulainen, Sanna Lensu, Lauren G Koch, Steve L Britton, Paul L Greenhaff, Kenneth Smith, Philip J Atherton
Current methods to quantify RNA dynamics are beset with limitations. Here, we developed a novel stable isotope (D2O)-methodology to quantify RNA synthesis (i.e. ribosomal biogenesis) in cells, animal models, and humans. Firstly, proliferating C2C12 cells were incubated in D2O-enriched media and myotubes (±) 50ng.ml(-1) IGF-1. Secondly, rat quadriceps [untrained n=9; 7-wks interval-"like" training n=13] were collected after ~3-wks D2O (70-Atom%) administration, with body-water enrichment (BWE) monitored via blood sampling...
August 15, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28811141/the-pharmacokinetic-profile-of-synthetic-cathinones-in-a-pregnancy-model
#7
Lauren G Strange, Kerri Kochelek, Robert Keasling, Stacy D Brown, Brooks B Pond
In recent years, the abuse of synthetic cathinones or 'bath salts' has become a major public health concern. Although these compounds were initially sold legally and labeled "not for human consumption", the 'bath salts' are psychostimulants, with similar structures and pharmacologic mechanisms to cocaine, the amphetamines, and 3,4 methylendioxymethamphetamine (MDMA, Molly, or Ecstasy). The reported use of these substances by women of child-bearing age highlights the necessity of studies seeking to delineate risks of prenatal exposure...
August 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28811088/primary-prevention-aspirin-use-in-high-risk-patients-a-pharmacist-intervention-and-comparison-of-risk-stratification-tools
#8
Scott A Coon, Amie D Brooks, Stephen E Wolff
OBJECTIVES: The objectives of this project are 1) to describe aspirin use for primary prevention in an underserved, minority population; 2) to determine the impact of a pharmacist-led intervention on the prevalence of aspirin use for primary prevention; and 3) to compare aspirin indications based on Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) risk score. METHODS: Men and women age 45-79 and 55-79 years, respectively, without ASCVD were screened for aspirin use...
August 12, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28810987/deployment-length-inflammatory-markers-and-ambulatory-blood-pressure-in-military-couples
#9
Stephanie Brooks Holliday, Amy DeSantis, Anne Germain, Daniel J Buysse, Karen A Matthews, Wendy M Troxel
INTRODUCTION: Changes in the frequency, duration, and nature of military deployments over the past 14 years have spurred efforts to understand the effects of deployment on the health of military service members and their spouses. However, few studies have examined the impact of deployments on health outcomes in both veterans and their partners. This study aims to examine the association between deployment length and health, including ambulatory blood pressure (BP) and stress-related markers of inflammation, in military veterans and their spouses...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810907/schr%C3%A3-dinger-s-microbes-tools-for-distinguishing-the-living-from-the-dead-in-microbial-ecosystems
#10
REVIEW
Joanne B Emerson, Rachel I Adams, Clarisse M Betancourt Román, Brandon Brooks, David A Coil, Katherine Dahlhausen, Holly H Ganz, Erica M Hartmann, Tiffany Hsu, Nicholas B Justice, Ivan G Paulino Lima, Julia C Luongo, Despoina S Lymperopoulou, Cinta Gomez-Silvan, Brooke Rothschild-Mancinelli, Melike Balk, Curtis Huttenhower, Andreas Nocker, Parag Vaishampayan, Lynn J Rothschild
While often obvious for macroscopic organisms, determining whether a microbe is dead or alive is fraught with complications. Fields such as microbial ecology, environmental health, and medical microbiology each determine how best to assess which members of the microbial community are alive, according to their respective scientific and/or regulatory needs. Many of these fields have gone from studying communities on a bulk level to the fine-scale resolution of microbial populations within consortia. For example, advances in nucleic acid sequencing technologies and downstream bioinformatic analyses have allowed for high-resolution insight into microbial community composition and metabolic potential, yet we know very little about whether such community DNA sequences represent viable microorganisms...
August 16, 2017: Microbiome
https://www.readbyqxmd.com/read/28810064/the-rural-and-remote-health-workforce-of-the-future
#11
Fiona Brooke
No abstract text is available yet for this article.
August 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28809123/-18-fdg-pet-ct-in-routine-surveillance-of-asymptomatic-patients-following-treatment-of-sinonasal-neoplasms
#12
Alan D Workman, Jordan T Glicksman, Arjun K Parasher, Ryan M Carey, Steven G Brooks, David W Kennedy, Seyed A Nabavizadeh, Kim O Learned, James N Palmer, Nithin D Adappa
Objective Sinonasal neoplasms have a high rate of recurrence following treatment, and current guidelines support the use of a variety of surveillance techniques. Recent work demonstrates that performance parameters of surveillance modalities may differ with sinonasal tumors in particular when compared with head and neck tumors overall. This study aims to characterize the value of (18)fluorodeoxyglucose ((18)FDG) positron emission tomography/computed tomography (PET/CT) as a screening tool in asymptomatic patients...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28809079/changes-in-the-use-of-erythropoiesis-stimulating-agents-esas-and-red-blood-cell-transfusion-in-patients-with-cancer-amidst-regulatory-and-reimbursement-changes
#13
Prasad L Gawade, Jesse A Berlin, David H Henry, Dianne Tomita, Barry D Brooks, Janet Franklin, Brian D Bradbury, Cathy W Critchlow
PURPOSE: Evaluate changes in use of erythropoiesis-stimulating agents (ESAs) and red blood cell transfusion in cancer patients receiving myelosuppressive chemotherapy following regulatory and reimbursement actions. METHODS: Calendar year patient cohorts (2005-2013) with breast, colorectal, lung, multiple myeloma, non-Hodgkin lymphoma, ovarian, or prostate cancer and receiving myelosuppressive chemotherapy were identified within the Marketscan database. Incidence of ESA treatment and transfusion were estimated in each year, as was median number of ESA administrations...
August 14, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28808875/ssat-state-of-the-art-conference-current-surgical-management-of-gastric-tumors
#14
Jeffrey A Norton, Teresa Kim, Joseph Kim, Martin D McCarter, Kaitlyn J Kelly, Joyce Wong, Jason K Sicklick
INTRODUCTION: The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies. METHODS: In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery...
August 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28808145/-stressed-about-air-pollution-time-for-personal-action
#15
EDITORIAL
Robert D Brook, Sanjay Rajagopalan
No abstract text is available yet for this article.
August 15, 2017: Circulation
https://www.readbyqxmd.com/read/28808019/next-step-in-the-ongoing-arms-race-between-myxoma-virus-and-wild-rabbits-in-australia-is-a-novel-disease-phenotype
#16
Peter J Kerr, Isabella M Cattadori, June Liu, Derek G Sim, Jeff W Dodds, Jason W Brooks, Mary J Kennett, Edward C Holmes, Andrew F Read
In host-pathogen arms races, increases in host resistance prompt counteradaptation by pathogens, but the nature of that counteradaptation is seldom directly observed outside of laboratory models. The best-documented field example is the coevolution of myxoma virus (MYXV) in European rabbits. To understand how MYXV in Australia has continued to evolve in wild rabbits under intense selection for genetic resistance to myxomatosis, we compared the phenotypes of the progenitor MYXV and viral isolates from the 1950s and the 1990s in laboratory rabbits with no resistance...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807994/a-novel-computational-model-predicts-key-regulators-of-chemokine-gradient-formation-in-lymph-nodes-and-site-specific-roles-for-ccl19-and-ackr4
#17
Mohammad Jafarnejad, David C Zawieja, Bindi S Brook, Robert J B Nibbs, James E Moore
The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. CCR7-dependent navigation is determined by the distribution of extracellular CCL19 and CCL21, which form concentration gradients at specific microanatomical locations. The mechanisms underpinning the establishment and regulation of these gradients are poorly understood. In this article, we have incorporated multiple biochemical processes describing the CCL19-CCL21-CCR7-ACKR4 network into our model of LN fluid flow to establish a computational model to investigate intranodal chemokine gradients...
August 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28806780/the-arac-negative-regulator-family-modulates-the-activity-of-histone-like-proteins-in-pathogenic-bacteria
#18
Araceli E Santiago, Michael B Yan, Tracy H Hazen, Brooke Sauder, Mario Meza-Segura, David A Rasko, Melissa M Kendall, Fernando Ruiz-Perez, James P Nataro
The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella spp., Shigella spp., Yersinia spp., Citrobacter spp., and pathogenic E. coli strains. We have previously reported broad effects of the ANR members on regulators of the AraC/XylS family. Here, we interrogate possible broader effects of the ANR members on the bacterial transcriptome. Our studies focused on Aar (AggR-activated regulator), an ANR family archetype in enteroaggregative E...
August 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28805829/lineage-specific-dynamic-and-pre-established-enhancer-promoter-contacts-cooperate-in-terminal-differentiation
#19
Adam J Rubin, Brook C Barajas, Mayra Furlan-Magaril, Vanessa Lopez-Pajares, Maxwell R Mumbach, Imani Howard, Daniel S Kim, Lisa D Boxer, Jonathan Cairns, Mikhail Spivakov, Steven W Wingett, Minyi Shi, Zhixin Zhao, William J Greenleaf, Anshul Kundaje, Michael Snyder, Howard Y Chang, Peter Fraser, Paul A Khavari
Chromosome conformation is an important feature of metazoan gene regulation; however, enhancer-promoter contact remodeling during cellular differentiation remains poorly understood. To address this, genome-wide promoter capture Hi-C (CHi-C) was performed during epidermal differentiation. Two classes of enhancer-promoter contacts associated with differentiation-induced genes were identified. The first class ('gained') increased in contact strength during differentiation in concert with enhancer acquisition of the H3K27ac activation mark...
August 14, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28805343/rest-and-exercise-hemodynamic-and-metabolic-findings-in-active-duty-soldiers-referred-for-cardiac-catheterization-to-exclude-heart-disease-insights-from-past-invasive-cardiopulmonary-exercise-testing-using-multisensor-high-fidelity-catheters
#20
James A Watts, Faith R Kelly, Terry D Bauch, Joseph P Murgo, Bernard J Rubal
OBJECTIVE: This study describes results of iCPET from the past, which used submaximal stress and multisensor high-fidelity catheters to exclude heart disease in a unique population of young adults. BACKGROUND: There has been resurgence in comprehensive hemodynamic evaluation of complex cardiovascular patients. Although dynamic assessments during cardiac catheterization have become commonplace, there remains limited information regarding left and right heart hemodynamic changes during supine exercise in young adults...
May 8, 2017: Catheterization and Cardiovascular Interventions
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