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https://www.readbyqxmd.com/read/28727821/advances-in-using-internet-searches-to-track-dengue
#1
Shihao Yang, Samuel C Kou, Fred Lu, John S Brownstein, Nicholas Brooke, Mauricio Santillana
Dengue is a mosquito-borne disease that threatens over half of the world's population. Despite being endemic to more than 100 countries, government-led efforts and tools for timely identification and tracking of new infections are still lacking in many affected areas. Multiple methodologies that leverage the use of Internet-based data sources have been proposed as a way to complement dengue surveillance efforts. Among these, dengue-related Google search trends have been shown to correlate with dengue activity...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28727763/loss-of-receptor-activity-modifying-protein-2-in-mice-causes-placental-dysfunction-and-alters-pth1r-regulation
#2
Mahita Kadmiel, Brooke C Matson, Scott T Espenschied, Patricia M Lenhart, Kathleen M Caron
Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function. Ramp2 has been primarily characterized in association with calcitonin receptor-like receptor (Calcrl, CLR), forming the canonical receptor complex for the endocrine peptide adrenomedullin (Adm, AM). However, we previously demonstrated that Ramp2+/- female mice display a constellation of endocrine-related phenotypes that are distinct from those of Adm+/- and Calcrl+/- mice, implying that RAMP2 has physiological functions beyond its canonical complex...
2017: PloS One
https://www.readbyqxmd.com/read/28727528/racial-ethnic-and-socioeconomic-disparities-in-hydration-status-among-us-adults-and-the-role-of-tap-water-and-other-beverage-intake
#3
Carolyn J Brooks, Steven L Gortmaker, Michael W Long, Angie L Cradock, Erica L Kenney
OBJECTIVES: To evaluate whether differences in tap water and other beverage intake explain differences in inadequate hydration among US adults by race/ethnicity and income. METHODS: We estimated the prevalence of inadequate hydration (urine osmolality ≥ 800 mOsm/kg) by race/ethnicity and income of 8258 participants aged 20 to 74 years in the 2009 to 2012 National Health and Nutrition Examination Survey. Using multivariable regression models, we estimated associations between demographic variables, tap water intake, and inadequate hydration...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28727037/assessment-of-objective-measures-of-beef-steak-juiciness-and-their-relationships-to-sensory-panel-juiciness-ratings
#4
L W Lucherk, T G O'Quinn, J F Legako, R J Rathmann, J C Brooks, M F Miller
The objective of this study was to evaluate multiple instrumental measures of beef juiciness and determine their relationships with sensory panel juiciness ratings. Treatments were selected to maximize variation in juiciness and included 5 USDA quality grades (Prime, upper two-thirds Choice, lower one-third Choice, Select, and Standard) as well as 2 enhanced Select treatments (112 and 107% of the initial raw weight) and were prepared to 3 degrees of doneness (DOD; rare [66°C], medium [71°C], and well done [77°C])...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726601/zika-virus-infection-in-patient-with-no-known-risk-factors-utah-usa-2016
#5
Elisabeth R Krow-Lucal, Shannon A Novosad, Angela C Dunn, Carolyn R Brent, Harry M Savage, Ary Faraji, Dallin Peterson, Andrew Dibbs, Brook Vietor, Kimberly Christensen, Janeen J Laven, Marvin S Godsey, Bryan Christensen, Brigette Beyer, Margaret M Cortese, Nina C Johnson, Amanda J Panella, Brad J Biggerstaff, Michael Rubin, Scott K Fridkin, J Erin Staples, Allyn K Nakashima
In 2016, Zika virus disease developed in a man (patient A) who had no known risk factors beyond caring for a relative who died of this disease (index patient). We investigated the source of infection for patient A by surveying other family contacts, healthcare personnel, and community members, and testing samples for Zika virus. We identified 19 family contacts who had similar exposures to the index patient; 86 healthcare personnel had contact with the index patient, including 57 (66%) who had contact with body fluids...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28725032/remora-cranial-vein-morphology-and-its-functional-implications-for-attachment
#6
Brooke E Flammang
Remora fishes adhere to, and maintain long-term, reversible attachment with, surfaces of varying roughness and compliance under wetted high-shear conditions using an adhesive disc that evolved from the dorsal fin spines typical of other fishes. Evolution of this complex hierarchical structure required extensive reorganization of the skull and fin spines, but the functional role of the soft tissues of the disc are poorly understood. Here I show that remora cranial veins are highly-modified in comparison to those of other vertebrates; they are transposed anteriorly and enlarged, and lie directly ventral to the disc on the dorsum of the cranium...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724697/facts-and-values-on-the-acceptability-of-risks-in-children-s-sport-using-the-example-of-rugby-a-narrative-review
#7
REVIEW
Kenneth Lincoln Quarrie, John H M Brooks, Nicholas Burger, Patria A Hume, Steve Jackson
A clash of values has been identified between those who assert that:1. all childhood injuries, regardless of origin, are inherently undesirable and should be prevented and;2. those who believe that some measure of injury to children is an acceptable compromise for the physical benefits associated with physical activity and the development of abilities to appraise and deal with risks.A debate regarding whether the tackles and collisions permitted in schools' rugby represent acceptable risks, and what steps should be taken if they do not, exemplifies the issue...
August 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28724455/a-seroprevalence-study-to-determine-the-frequency-of-hantavirus-infection-in-people-exposed-to-wild-and-pet-fancy-rats-in-england
#8
J M Duggan, R Close, L McCann, D Wright, M Keys, N McCarthy, T Mannes, A Walsh, A Charlett, T J G Brooks
Recent cases of acute kidney injury due to Seoul hantavirus infection from exposure to wild or pet fancy rats suggest this infection is increasing in prevalence in the UK. We conducted a seroprevalence study in England to estimate cumulative exposure in at-risk groups with contact with domesticated and wild rats to assess risk and inform public health advice. From October 2013 to June 2014, 844 individual blood samples were collected. Hantavirus seroprevalence amongst the pet fancy rat owner group was 34.1% (95% CI 23·9-45·7%) compared with 3·3% (95% CI 1·6-6·0) in a baseline control group, 2·4% in those with occupational exposure to pet fancy rats (95% CI 0·6-5·9) and 1·7% with occupational exposure to wild rats (95% CI 0·2-5·9)...
July 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28724391/hormone-receptor-status-of-a-first-primary-breast-cancer-predicts-contralateral-breast-cancer-risk-in-the-wecare-study-population
#9
Anne S Reiner, Charles F Lynch, Julia S Sisti, Esther M John, Jennifer D Brooks, Leslie Bernstein, Julia A Knight, Li Hsu, Patrick Concannon, Lene Mellemkjær, Marc Tischkowitz, Robert W Haile, Ronglai Shen, Kathleen E Malone, Meghan Woods, Xiaolin Liang, Monica Morrow, Jonine L Bernstein
BACKGROUND: Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covariates such as treatment, family history of breast cancer, and BRCA1/2 mutation carrier status was not available. In a large, population-based, case-control study, we evaluated whether tumor characteristics of the first primary breast cancer are associated with risk of developing second primary asynchronous CBC, overall and in subgroups of interest, including among BRCA1/2 mutation non-carriers, women who are not treated with tamoxifen, and women without a breast cancer family history...
July 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28724148/integrative-medicine-in-residency-feasibility-and-effectiveness-of-an-online-program
#10
Patricia Lebensohn, Benjamin Kligler, Audrey J Brooks, Raymond Teets, Michele Birch, Paula Cook, Victoria Maizes
BACKGROUND AND OBJECTIVES: Online curricular interventions in residency have been proposed to address challenges of time, cost, and curriculum consistency. This study is designed to determine the feasibility and effectiveness of a longitudinal, multisite online curriculum in integrative medicine (IMR) for residents. METHODS: Residents from eight family medicine programs undertook the 200-hour online IMR curriculum. Their medical knowledge (MK) scores at completion were compared to a control group from four similar residency programs...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28723479/infectious-complications-of-circumcision-and-their-prevention
#11
REVIEW
Itzhak Brook
CONTEXT: A growing body of evidence supports the health benefits of circumcision, but the occurrence of infectious complications is of concern. OBJECTIVE: To review literature presenting past data and studies of infectious complications of circumcision and their prevention. EVIDENCE ACQUISITION: A literature search was conducted of the Cochrane Library, Embase, Turning Research into Practice, PubMed, and Medline databases from their inception through June 25, 2015...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722570/mycobacterium-tuberculosis-infection-in-close-childhood-contacts-of-adults-with-pulmonary-tuberculosis-is-increased-by-secondhand-exposure-to-tobacco
#12
Ifedayo M O Adetifa, Lindsay Kendall, Simon Donkor, Moses D Lugos, Abdulrahman S Hammond, Patrick K Owiafe, Martin O C Ota, Roger H Brookes, Philip C Hill
Tobacco use is a major risk factor for tuberculosis (TB). Secondhand smoke (SHS) is also a risk factor for TB and to a lesser extent, Mycobacterium tuberculosis infection without disease. We investigated the added risk of M. tuberculosis infection due to SHS exposure in childhood contacts of TB cases in The Gambia. Participants were childhood household contacts aged ≤ 14 years of newly diagnosed pulmonary TB (PTB) cases. The intensity of exposure to the case was categorized according to whether contacts slept in the same room, same house, or a different house as the case...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722487/left-ventricular-hypertrophy-in-acute-stroke-patients-with-known-hypertension
#13
Askiel Bruno, Desiree D Brooks, Taryn A Abrams, Mitra D Poorak, Drew Gunio, Prianka K Kandhal, Aleena Lakhanpal, Arun K Nagabandi, Abiodun E Akinwuntan, Stephen Looney, Pascha E Schafer
BACKGROUND: Despite effective treatments, hypertension remains uncontrolled in nearly half of the people with hypertension in the United States. Uncontrolled hypertension leads to end organ damage, such as left ventricular hypertrophy (LVH). To identify reasons for uncontrolled hypertension, we interviewed acute stroke patients with a history of hypertension and evaluated for LVH. METHODS: Using a standardized questionnaire, we collected demographic, socioeconomic, and health-care data in 300 acute ischemic and hemorrhagic stroke patients in one hospital...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28719634/taxa-area-relationship-of-aquatic-fungi-on-deciduous-leaves
#14
Sofia Duarte, Fernanda Cássio, Cláudia Pascoal, Felix Bärlocher
One of the fundamental patterns in macroecology is the increase in the number of observed taxa with size of sampled area. For microbes, the shape of this relationship remains less clear. The current study assessed the diversity of aquatic fungi, by the traditional approach based on conidial morphology (captures reproducing aquatic hyphomycetes) and next generation sequencing (NGS; captures other fungi as well), on graded sizes of alder leaves (0.6 to 13.6 cm2). Leaves were submerged in two streams in geographically distant locations: the Oliveira Stream in Portugal and the Boss Brook in Canada...
2017: PloS One
https://www.readbyqxmd.com/read/28719280/multiplex-serologic-assessment-of-schistosomiasis-in-western-kenya-antibody-responses-in-preschool-aged-children-as-a-measure-of-reduced-transmission
#15
Kimberly Y Won, Henry M Kanyi, Faith M Mwende, Ryan E Wiegand, E Brook Goodhew, Jeffrey W Priest, Yeuk-Mui Lee, Sammy M Njenga, W Evan Secor, Patrick J Lammie, Maurice R Odiere
AbstractCurrently, impact of schistosomiasis control programs in Schistosoma mansoni-endemic areas is monitored primarily by assessment of parasitologic indicators only. Our study was conducted to evaluate the use of antibody responses as a way to measure the impact of schistosomiasis control programs. A total of 3,612 serum samples collected at three time points from children 1-5 years of age were tested for antibody responses to two schistosome antigens (soluble egg antigen [SEA] and Sm25) by multiplex bead assay...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719232/long-term-outcomes-of-a-multidisciplinary-weight-management-intervention-for-youth-with-disabilities
#16
Ashleigh A Pona, Meredith L Dreyer Gillette, Cathleen Odar Stough, Janelle K Gerling, Brooke R Sweeney
BACKGROUND: Youth with disabilities are at increased risk for obesity compared with their typically developing peers and face unique barriers to healthy lifestyles. A limited number of weight management programs have been specifically tailored to accommodate youth with disabilities, and outcomes research in this population is scarce. We investigated the effectiveness of a specialized multidisciplinary weight management program for children with disabilities. METHODS: Youth (N = 115) ages 2-18 years (mean age = 10...
July 18, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28718821/tick-haller-s-organ-a-new-paradigm-for-arthropod-olfaction-how-ticks-differ-from-insects
#17
Ann L Carr, Robert D Mitchell Iii, Anirudh Dhammi, Brooke W Bissinger, Daniel E Sonenshine, R Michael Roe
Ticks are the vector of many human and animal diseases; and host detection is critical to this process. Ticks have a unique sensory structure located exclusively on the 1st pairs of legs; the fore-tarsal Haller's organ, not found in any other animals, presumed to function like the insect antennae in chemosensation but morphologically very different. The mechanism of tick chemoreception is unknown. Utilizing next-generation sequencing and comparative transcriptomics between the 1st and 4th legs (the latter without the Haller's organ), we characterized 1st leg specific and putative Haller's organ specific transcripts from adult American dog ticks, Dermacentor variabilis...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718397/the-vitamin-d-standardization-program-vdsp-manual-for-retrospective-laboratory-standardization-of-serum-25-hydroxyvitamin-d-data
#18
Ramon Durazo-Arvizu, Lu Tian, Stephen Brooks, Kurtis Sarafin, Kevin Cashman, Mairead Kiely, Joyce Merkel, Gary Myers, Paul Coates, Christopher Sempos
Low concentrations of total 25-hydroxyvitamin D [25(OH)D], the principal biological measure of vitamin D status, have been associated with clinical and public health outcomes. The determination of levels under which there is an increase in the risk of disease, as well as comparisons across populations, have been difficult to establish due the large assay variability in measuring 25(OH)D. Accordingly, the Vitamin D Standardization Program (VDSP) includes the retrospective standardization of existing 25(OH)D values collected by epidemiological and clinical studies, as well as clinical trials, as one of its main objectives...
July 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28717764/comprehensive-human-papillomavirus-genotyping-in-cervical-squamous-cell-carcinomas-and-its-relevance-to-cervical-cancer-prevention-in-malawian-women
#19
Brooke E Howitt, Michael Herfs, Tamiwe Tomoka, Steve Kamiza, Tarik Gheit, Massimo Tommasino, Philippe Delvenne, Christopher P Crum, Danny Milner
PURPOSE: Cervical squamous cell carcinoma (SCC) continues to be a significant cause of cancer morbidity and is the third leading cause of cancer-related death in women worldwide. In sub-Saharan Africa, cervical cancer is not only the most common female cancer but also the leading cause of cancer-related deaths in women. Malawi, in particular, has the highest burden of cervical cancer. With the increasing use of human papillomavirus (HPV) vaccination, documenting the prevalent HPV types in those high-risk populations is necessary to both manage expectations of HPV vaccination and guide future vaccine development...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716823/father-loss-and-child-telomere-length
#20
Colter Mitchell, Sara McLanahan, Lisa Schneper, Irv Garfinkel, Jeanne Brooks-Gunn, Daniel Notterman
BACKGROUND AND OBJECTIVES: Father loss during childhood has negative health and behavioral consequences, but the biological consequences are unknown. Our goal was to examine how father loss (because of separation and/or divorce, death, or incarceration) is associated with cellular function as estimated by telomere length. METHODS: Data come from the 9-year follow-up of the Fragile Families and Child Wellbeing Study, a birth cohort study of children in 20 large American cities (N = 2420)...
July 18, 2017: Pediatrics
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