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Maciej Kajor, Michał Kukla, Marek Waluga, Łukasz Liszka, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Mateusz Chapuła, Anna Kostrząb-Zdebel, Rafał J Bułdak, Tomasz Sawczyn, Marek Hartleb
The aim of this study was to investigate hepatic chemerin mRNA, serum chemerin concentration, and immunohistochemical staining for chemerin and and chemokine receptor-like 1 (CMKLR1) in hepatic tissue in 56 morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to search for a relationship with metabolic and histopathological features. Chemerin mRNA was assessed by quantitative real-time PCR, chemerin, and CMKLR1 immunohistochemical expression with specific antibodies, while serum chemerin concentration was assessed with commercially available enzyme-linked immunosorbent assays...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Soheil Tavakolpour, Mohammad Darvishi, Hajar Sadat Mirsafaei, Mojtaba Ghasemiadl
BACKGROUND: Women of childbearing age who have developed chronic hepatitis B (CHB) infection, especially HBeAg-positive highly viraemic pregnant women, are largely responsible for the familial transmission of the infection. Therefore, choosing the most effective and safest antiviral medications to manage pregnant CHB patients is of crucial importance. MATERIALS AND METHODS: The PubMed and Scopus databases were searched through September 2017, for all the journal articles possessing original results regarding treatment of CHB pregnant women with any nucleos(t)ide analogue (NA) therapies, including lamivudine (LAM), adefovir (ADV), entecavir (ETV), telbivudine (LdT), and tenofovir (TDF)...
October 11, 2017: Infectious Diseases
Meifang Han, Yong Li, Wenyu Wu, Yuanya Zhang, Weiming Yan, Xiaoping Luo, Qin Ning
Our previous OSST study shows that switching to pegylated interferon (Peg-IFN)-α2a results in higher rates of response hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) loss at the end of treatment, compared with nucleot(s)ide analogues (NAs) monotherapy in long term NA-treated chronic hepatitis B (CHB) patients. In order to characterize the correlation between Peg-IFN-α antiviral effect and IFN-inducing signaling in CHB patients who switched to Peg-IFN from long time entecavir (ETV) treatment, we investigated the dynamic expression of interferon-stimulated genes (ISGs), including STAT1, MX, and a negative regulatory factor, suppressor of cytokine signaling 3(SOCS3), which negatively regulate IFN JAK-STAT signaling pathway by interacting with STAT1 and STAT2, in peripheral blood and paired liver samples, obtained from 54 CHB patients enrolled in a clinical trial, OSST study...
October 6, 2017: Antiviral Research
Megan Y Nas, Nicholas P Cianciotto
Stenotrophomonas maltophilia, a Gram-negative, multi-drug-resistant bacterium, is increasingly recognized as a key opportunistic pathogen. Thus, we embarked upon an investigation of S. maltophilia iron acquisition. To begin, we determined that the genome of strain K279a is predicted to encode a complete siderophore system, including a biosynthesis pathway, an outer-membrane receptor for ferrisiderophore, and other import and export machinery. Compatible with these data, K279a and other clinical isolates of S...
October 6, 2017: Microbiology
Philip M Westgate, Enrique Gomez-Pomar
In the face of the current Neonatal Abstinence Syndrome (NAS) epidemic, there is considerable variability in the assessment and management of infants with NAS. In this manuscript, we particularly focus on NAS assessment, with special attention given to the popular Finnegan Neonatal Abstinence Score (FNAS). A major instigator of the problem of variable practices is that multiple modified versions of the FNAS exist and continue to be proposed, including shortened versions. Furthermore, the validity of such assessment tools has been questioned, and as a result, the need for better tools has been suggested...
2017: Frontiers in Pediatrics
Lucieli Dias Pedreschi Chaves, Vivian Aline Mininel, Jaqueline Alcântara Marcelino da Silva, Larissa Roberta Alves, Maria Ferreira da Silva, Silvia Helena Henriques Camelo
Objective: To reflect on nursing supervision as a management tool for care comprehensiveness by nurses, considering its potential and limits in the current scenario. Method: A reflective study based on discourse about nursing supervision, presenting theoretical and practical concepts and approaches. Results: Limits on the exercise of supervision are related to the organization of healthcare services based on the functional and clinical model of care, in addition to possible gaps in the nurse training process and work overload...
September 2017: Revista Brasileira de Enfermagem
Cassiana Mendes Bertoncello Fontes, Daniele Vieira de Menezes, Maria Helena Borgato, Marcos Roberto Luiz
Objectives: describe how the process of breaking bad news is established and identify how nurses approach the task of giving bad news. Method: integrative review of the literature for articles in Portuguese and English published between 1993-2014, in the databases: Bireme, PubMed, Scopus, Web of Science, CINAHL and Embase. Nine articles were included using the selection flow chart. A digital form was completed for each article according to the Consolidated Criteria for Reporting Qualitative Research checklist and the level of scientific evidence was determined...
September 2017: Revista Brasileira de Enfermagem
Cláudia Cristiane Filgueira Martins Rodrigues, Viviane Euzébia Pereira Santos, Paulo Sousa
Objective: To analyze studies on stress, Burnout Syndrome, and patient safety in the scope of nursing care in the hospital environment. Method: This was an integrative literature review. Data collection was performed in February 2016 in the following databases: Medical Literature Analysis and Retrieval System Online - PubMed/MEDLINE, Latin American and Caribbean Literature in Health Sciences - LILACS. Results: Ten scientific productions were selected, which listed that factors contributing to stress and Burnout Syndrome of nursing professionals are the work environment as a source of stress, and excessive workload as a source of failures...
September 2017: Revista Brasileira de Enfermagem
Maria de Fátima Gomes Lima, Alice Maria Correia Pequeno, Dafne Paiva Rodrigues, Cleide Carneiro, Ana Patrícia Pereira Morais, Francisca Diana da Silva Negreiros
Objective: To analyze the development of professional skills in an obstetric nursing graduate course. Method: Qualitative research, applying semi-structured interviews with 11 students in the obstetric nursing specialization at the State University of Ceará. Data was submitted to thematic review. Results: According to the subjects, the course offers the development of skills to strengthen and expand the range of activities in obstetric nursing...
September 2017: Revista Brasileira de Enfermagem
Maria Aparecida Salci, Betina Hörner Schlindwein Meirelles, Denise Maria Vieira Guerreiro da Silva
Objective: To assess the prevention by primary health care providers of chronic complications of diabetes mellitus according to the complex thinking theoretical approach. Method: Evaluative research based on the complex thinking theoretical approach. The following techniques for data collection were used: interviews with 38 participants; observation in collective and individual appointments; and analysis of medical records of people with diabetes. The triangulation applied for data analysis was the ATLAS...
September 2017: Revista Brasileira de Enfermagem
Teresa Cristina da Silva Kurimoto, Claudia Maria de Mattos Penna, Débora Isane Ratner Kirschbaum Nitkin
Objective: To understand mental health nursing care based on the concept of the subject of the unconscious proposed by Lacan. Method: A narrative study was carried out with 19 nurses, chosen based on their theoretical approach or referral by other participants, through the snowball sampling technique. The interviews were carried out in person or digitally, and were recorded and fully transcribed. Results: The analysis was carried out based on Freudian and Lacanian psychoanalysis, approaching nursing care as it acts on the body, secretions, and excretions, to distinguish it from the spirit of fineness...
September 2017: Revista Brasileira de Enfermagem
Jacqueline de Souza, Letícia Yamawaka de Almeida, Margarita Antonia Villar Luis, Andreia Fernanda Nievas, Tatiana Maria Coelho Veloso, Sara Pinto Barbosa, Bianca Cristina Ciccone Giacon, Francine Baltazar Assad
Objective: to analyze the management of mental health needs in primary care as perceived by Family Health Strategy professionals. Method: this was a qualitative descriptive exploratory study developed within the coverage area of five family health teams. The data were collected using observation, group interviews, individual semi-structured interviews, and focus groups. Content analysis was conducted using text analysis software and interpretation was based on the corresponding analytical structures...
September 2017: Revista Brasileira de Enfermagem
Yi-Jun Liao, Yen-Chang Li, Shou-Wu Lee, Chun-Ying Wu, Sheng-Shun Yang, Hong-Zen Yeh, Chi-Sen Chang, Teng-Yu Lee
BACKGROUND: Lack of nucleos(t)ide analogue (NA) prophylaxis prior to chemotherapy is a common problem worldwide. The efficacy of newer-generation NAs in the rescue for the hepatitis B virus (HBV) reactivation has not been confirmed. We aimed to compare lamivudine (LVD) and entecavir (ETV) in the rescue of chemotherapy-induced HBV flare-up. METHODS: In this retrospective cohort study, we screened all HBV carriers who received therapeutic LVD or ETV for hepatitis flare-up after chemotherapy between January 1, 2004 and December 31, 2015...
September 30, 2017: Journal of the Chinese Medical Association: JCMA
Enrique Gomez Pomar, Loretta P Finnegan, Lori Devlin, Henrietta Bada, Vanessa A Concina, Katrina T Ibonia, Philip M Westgate
OBJECTIVE: To develop a simplified Finnegan Neonatal Abstinence Scoring System (sFNAS) that will highly correlate with scores ≥8 and ≥12 in infants being assessed with the FNAS. DESIGN, SETTING AND PARTICIPANTS: This is a retrospective analysis involving 367 patients admitted to two level IV neonatal intensive care units with a total of 40 294 observations. Inclusion criteria included neonates with gestational age ≥37 0/7 weeks, who are being assessed for neonatal abstinence syndrome (NAS) using the FNAS...
September 27, 2017: BMJ Open
Ting Zhao, Yue He, Huali Chen, Yan Bai, Wenjing Hu, Liangke Zhang
We aimed to construct a novel nano-assembly carrying apigenin (APG), a hydrophobic drug, and to evaluate its in vitro targeting ability for A549 cells overexpressing CD44 receptors. The apigenin-loaded sodium hyaluronate nano-assemblies (APG/SH-NAs) were assembled by multiple non-covalent interactions between sodium hyaluronate (SH) and APG. The prepared APG/SH-NAs exhibited a small average size and narrow particle size distribution. In addition, satisfactory encapsulation efficiency and drug loading were obtained...
December 1, 2017: Carbohydrate Polymers
Selçuk Nas, Remzi Fışkın
BACKGROUND: The present study aims to investigate and to reveal the relationship between ABO blood groups and body mass index (BMI) and obesity among Turkish seafarers by using the health examination reports data obtained from 2009 to 2016. MATERIALS AND METHODS: The data on age, gender, weight, height and blood groups obtained from 298,247 medical examination reports of Turkish seafarers were used with the official permission of Directorate General of Health for Border and Coastal Areas...
2017: International Maritime Health
Kirsten H Ohler, Jennifer T Pham
We read with interest the recent study published in Pharmacotherapy evaluating morphine dosing to treat neonatal abstinence syndrome (NAS).(1) The authors attempted to address an important research question in a disease state which is a widespread problem with many unknowns related to its management.(2-4) In order to address these unknowns, future research of NAS should include the following key considerations. This article is protected by copyright. All rights reserved.
September 26, 2017: Pharmacotherapy
B C Gómez-Meda, G M Zúñiga-González, L V Sánchez-Orozco, A L Zamora-Perez, J P Rojas-Ramírez, A D Rocha-Muñoz, A A Sobrevilla-Navarro, M A Arellano-Avelar, A A Guerrero-de León, J S Armendáriz-Borunda, M G Sánchez-Parada
The Santiago River is one of the most contaminated rivers in Mexico, with heavy metal levels above the allowed limits. Scientific evidence indicates that chronic heavy metal exposure leads to cytogenotoxic effects. The aims of this study were to evaluate the genotoxic and cytotoxic effects of such exposure in buccal mucosa cells by micronucleus (MN) assay and to identify other nuclear abnormalities (NAs), such as nuclear buds (NBUDs), binucleated cells (BNs), pyknotic nuclei (PNs), karyorrhexis (KX), karyolysis (KL), and abnormally condensed chromatin (CC)...
September 26, 2017: Environmental Monitoring and Assessment
Mustafa Serdar Sağ, Sinem Sağ, İbrahim Tekeoğlu, Berna Solak, Ayhan Kamanlı, Kemal Nas, Halil Harman, Mine Kantar
BACKGROUND AND OBJECT: Rheumatoid arthritis (RA), insulin-dependent diabetes mellitus (IDDM), inflammatory bowel disease, systemic lupus erythematosus (SLE) and multiple sclerosis (MS) are some of the autoimmune diseases related to the decreases in Vitamin D levels. The same immunological properties as psoriasis, such as Th1/Th2 dysregulation, are seen in all of them. This study aims to compare 25-hidroksi Vitamin D (25-OHD) serum concentrations in patients with psoriasis and psoriatic arthritis...
September 8, 2017: Journal of Back and Musculoskeletal Rehabilitation
Ruth M Labardee, Jaime R Swartzwelder, Karen E Gebhardt, Justine A Pardi, Anna C Dawsey, R Brent Dixon, Steven W Cotten
OBJECTIVE: Neonatal abstinence syndrome (NAS) is a rising concern with unknown long-term effects. It is apparent that higher cost of care, impact on the community and reduced quality of life are associated with similar etiologies (e.g., fetal alcohol syndrome). Detection of drug exposure in utero allows for earlier intervention to potentially reduce undesired outcomes. Umbilical cord tissue (UCT) has been documented as a readily accessible specimen for detection of drug exposure and has emerged as an alternative specimen to meconium...
September 21, 2017: Clinical Biochemistry
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