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R P Vynogradova, V M Danilova, S P Yurasova
The article focuses on scientific and practical activity of the Department of Muscle Biochemistry of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of its foundation and development. Main findings and practical achievements in the area of muscle biochemistry are summarized and discussed.
January 2017: Ukrainian Biochemical Journal
K Ozturk, O F Nas, E Soylu, K Hacikurt, C Erdogan
PURPOSE: The purpose of this study was to retrospectively assess the potential of percutaneous transhepatic biliary drainage (PTBD) in patients with nondilated bile ducts (NDBD) using a transgallbladder opacification of the bile ducts. PATIENTS AND METHODS: Eight patients with NDBD (7 men, 1 women; median age, 65 years; Q1-Q3, 35-69 years; range, 22-77 years) who underwent PTBD after opacification of the bile ducts through the gallbladder were evaluated. Opacification of NDBD was performed using a retrograde injection of contrast material through the gallbladder...
December 8, 2017: Diagnostic and Interventional Imaging
Jingfeng Bi, Zheng Zhang, Enqiang Qin, Jun Hou, Shuiwen Liu, Zengmin Liu, Shuo Li, Zhenman Wei, Yanwei Zhong
Whether Nucleos(t)ide analogs(NA) treatment can delay the onset of HCC remains unclear. We retrospectively analyzed the clinical data of patients with HBV-related cirrhosis and HCC from 2000 to 2012. Cox proportional hazards model was used to explore the association between NA treatment and postponement of HCC development, the dependent variable was time interval from cirrhosis treatment towards the onset of HCC, and the covariates included age, sex, family history, compensation status at baseline. A total of 1155 HCC patients treated with NAs (n = 528, lamivudine, adefovir, entecavir) and non NA (n = 627) for more than 24 months before the occurrence of HCC were incorporated into the cohort...
November 14, 2017: Oncotarget
Fabio Nascimbeni, Stefano Ballestri, Mariana Verdehlho Machado, Alessandro Mantovani, Helena Cortez-Pinto, Giovanni Targher, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) encompasses simple steatosis and steatohepatitis (NASH) with or without fibrosis/cirrhosis and hepatocellular carcinoma. NAFLD occurs epidemically in most areas of the world, contributes to cardiovascular events and liver-related mortality and therefore exacts a major economic toll. Areas covered: Here we summarize what clinicians should know about NAFLD histopathology in adults. We report on the individual histological features and scoring systems of NAFLD: the NAFLD activity score (NAS) introduced by the NASH-Clinical Research Network, the "Fatty Liver Inhibition of Progression" algorithm and Steatosis, Activity, and Fibrosis (SAF) score...
December 11, 2017: Expert Review of Gastroenterology & Hepatology
Xuan Lu, Xue-Qing Li, Hai-Hong Qin, Bao-Min Feng, Xing-Hua Cheng, Qing-Xiong Yang, Da-Yong Yu, Li-Ying Shi, Zong-Xia Yu, Xue-Xun Fang
Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spectroscopic methods, especially 1H NMR, 13C NMR, 2D NMR, and HR-ESI-MS. The inhibitory effects on N1 and N2, two subtypes of neuraminidases (NAs), of these two compounds were assayed.
December 10, 2017: Journal of Asian Natural Products Research
Maria-Jesus Blanco, Daniel La, Quinn Coughlin, Caitlin A Newman, Andrew M Griffin, Boyd L Harrison, Francesco G Salituro
Endogenous and synthetic neuroactive steroids (NASs) or neurosteroids are effective modulators of multiple signaling pathways including receptors for the γ-aminobutyric acid A (GABAA) and glutamate, in particular N-methyl-d-aspartate (NMDA). These receptors are the major inhibitory and excitatory neurotransmitters in the central nervous system (CNS), and there is growing evidence suggesting that dysregulation of neurosteroid production plays a role in numerous neurological disorders. The significant unmet medical need for treatment of CNS disorders has increased the interest for these types of compounds...
December 2, 2017: Bioorganic & Medicinal Chemistry Letters
Matthew S Davids
With the recent approval of several effective and well-tolerated novel agents (NAs), including ibrutinib, idelalisib, venetoclax, and obinutuzumab, patients with chronic lymphocytic leukemia (CLL) have more therapeutic options than ever before. The availability of these agents is both an important advance for patients but also a challenge for practicing hematologist/oncologists to learn how best to sequence NAs, both with respect to chemoimmunotherapy (CIT) and to other NAs. The sequencing of NAs in clinical practice should be guided both by an individual patient's prognostic markers, such as FISH and immunoglobulin heavy chain variable region (IGHV)-mutation status, as well as the patient's medical comorbidities and goals of care...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
Feng Gao, Haitao Dai, Hongfei Pan, Yuanfang Chen, Jingkang Wang, Zhijian Chen
In this work, TiO2 nanorod arrays (TiO2-NAs) were modified by CuInS2 quantum dots (CuInS2 QDs) on the surface of the nanorods. The resultant TiO2-CuInS2 nanorod arrays (TiO2-CuInS2-NAs) were characterized by UV/Vis spectroscopy, transmission electronic microscopy (TEM), and X-ray diffraction (XRD). The TiO2-CuInS2-NAs were applied as scaffold for the preparation of organic-inorganic hybrid perovskite solar cells. In comparison with the solar cell devices based on TIO2-NAs, a significant improvement in the power conversion efficiency had been achieved and the highest efficiency was obtained as 11...
November 22, 2017: Journal of Colloid and Interface Science
Xiaolin Sheng, Rui Liu, Lujun Chen, Zihua Yin, Jianfeng Zhu
In this study, nitrifying bacteria were enriched in a membrane bioreactor (MBR, R1) and their bioaugmentation effectiveness was evaluated in another two MBRs (R2 and R3). Nitrifying activated sludge (NAS) with high nitrification activity of up to 3,000 mg-N/(L·d)-1 was successfully enriched in R1. The results showed that chemical oxygen demand concentration of 100-200 mg/L had no negative effect on NAS enrichment but reduced the ratio of bacterial nitrifiers. Moreover, the cell concentration of nitrifying bacteria in NAS, which was 3...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Maria Buffini, Séverine Goscinny, Ir Joris Van Loco, Anne P Nugent, Janette Walton, Albert Flynn, Michael J Gibney, Breige A McNulty
This research investigated the intakes of six intense sweeteners; acesulfame-K (E950), aspartame (E951), cyclamate (E952), saccharin (E954), sucralose (E955) and steviol glycosides (E960) in the diets of Irish adults, using data from the National Adult Nutrition Survey (NANS). A food label survey which included products currently available on the Irish market supplemented the analysis. Sweetener intakes were investigated using three different exposure scenarios; beginning with a crude assessment which assumed that all foods permitted to contain the additives of interest always did contain them, and at their maximum permitted level (Tier 1)...
December 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Nicholas E Hagemeier, Ivy A Click, Heather Flippin, Holly Gilliam, Alexandra Ross, Jeri Ann Basden, Ronald Carico
Background Maternal opioid use and neonatal abstinence syndrome (NAS) incidence have increased markedly in the US in recent years. Objectives (1) To assess prescribers' and community pharmacists' guideline-based NAS prevention behaviors; (2) to describe providers' perceptions of contraceptive appropriateness in female patients of childbearing age. Method Cross-sectional study of 100 randomly selected primary care physicians, 100 prescribers authorized to engage in in-office treatment of opioid use disorders with buprenorphine, 100 pain management clinic directors, and 100 community pharmacists in Tennessee (N = 400 providers total) to evaluate self-reported engagement in 15 NAS prevention behaviors and perceived appropriateness of 8 contraceptive methods in opioid using women of childbearing age...
December 5, 2017: International Journal of Clinical Pharmacy
Gareth Ryan, Anishnaabe Bimaadiziwin, Joe Dooley, Lianne Gerber Finn, Len Kelly
BACKGROUND: Infants with neonatal abstinence syndrome (NAS) experience withdrawal that occurs as a result of termination of placental opioid supply following delivery. Common symptoms include restlessness, tremors, agitation and gastrointestinal disturbances. Severe NAS is often treated using opioids and/or sedatives. Although commonly employed effectively in neonatal care, there is a lack of published information regarding nonpharmacological management of the NAS infant. OBJECTIVE: The purpose of this review was to summarize the current literature on nonpharmacological management of NAS...
December 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
Jorge Abel Trelles, Maria Jose Lapponiab
BACKGROUND: Nucleoside analogue (NAs) derivatives comprise a large family of pharmaceuticals clinically used as antitumoral and antiviral compounds. Originally, the production of NAs involved chemical synthesis, but a greener bioproduction alternative exists and involves the use of enzymes that catalyze transglycosylation reactions between modified purinic or pyrimidinic bases and sugars. To be considered as an option for industrial application, it is vital to immobilize these biocatalysts...
December 3, 2017: Current Pharmaceutical Design
Wenjia Wang, Youtong Xu, Xiaoxiao Wang, Bokun Zhang, Wenying Tian, Jinglai Zhang
Hydrothermal liquefaction (HTL) of microalgae Nannochloropsis (NAS) over various transition metal M/TiO2 (M = Fe, Co, Ni, Mo, and Mn) was investigated. Ni/TiO2 was the most effective catalyst to improve the yield and quality of biocrude and the liquefaction conversion. Ni/TiO2 was characterized by XRD, XRF, and XPS. The research of Effect of reaction temperature on HTL of NAS over Ni/TiO2 suggested that 300 °C led to a maximum biocrude yield of 48.23% and the highest liquefaction conversion of 89.28%...
November 20, 2017: Bioresource Technology
Anne Claire den Dulk, Xiaolei Shi, Cornelia J Verhoeven, Jeroen Dubbeld, Frans H J Claas, Ron Wolterbeek, Simone H Brand-Schaaf, Hein W Verspaget, Arantza Fariña Sarasqueta, Luc J W van de Laan, Herold J Metselaar, Bart van Hoek, Jaap Kwekkeboom, Dave L Roelen
Donor-specific alloantibodies (DSA) have been associated with rejection and shorter graft survival after orthotopic liver transplantation (OLT). We examined the role of DSA in non-anastomotic biliary strictures (NAS) after OLT. Patients receiving first OLT who developed NAS (n=68) and a control group without NAS (n=83), with pre-OLT and 12 months post-OLT serum samples were included. DSA were specified using the Luminex single antigen test. Risk factors for NAS and graft survival were analysed. The presence of preformed DSA was not significantly different between patients with NAS and controls (p=0...
November 29, 2017: Clinical Transplantation
Karuna Yadav, Prashanti Patel, Ashish Kumar Srivastava, T R Ganapathi
Iron is an indispensable element for plant growth and defense and hence it is essential to improve the plant's ability to accumulate iron. Besides, it is also an important aspect for human health. In view of this, we attempted to increase the iron content in banana cultivar Rasthali using MusaFer1 as a candidate gene. Initially, the expression of all five genes of the MusaFer family (MusaFer1-5) was quantified under iron-excess and -deficient conditions. The supplementation of 250 and 350 μM iron enhanced expression of all MusaFer genes; however, MusaFer1 was increased maximally by 2- and 4- fold in leaves and roots respectively...
2017: PloS One
Tatiana do Altíssimo Nogueira, Mayra Gonçalves Menegueti, Gleice da Silva Castro Perdoná, Maria Auxiliadora-Martins, Fernanda Maria Togeiro Fugulin, Ana Maria Laus
OBJECTIVES: To correlate the average number of nursing care hours dedicated to Intensive Care Unit (ICU) patients with nursing care indicators. METHOD: Transverse, descriptive study conducted between 2011 and 2013. Data were obtained from the electronic records system and from the nursing staff daily schedule. Generalized Linear Models were used for analysis. RESULTS: A total of 1,717 patients were included in the study. The average NAS (Nursing Activities Score) value was 54...
2017: PloS One
Teresa Broquetas, Montserrat Garcia-Retortillo, Juan José Hernandez, Marc Puigvehí, Nuria Cañete, Susana Coll, Beatriz Cabrero, Maria Dolors Giménez, Ricard Solà, José A Carrión
BACKGROUND: HBeAg-negative chronic hepatitis B patients require long-term nucleos(t)ide analogues(NAs) because loss of surface antigen (HBsAg) is unusual. Low quantitative HBsAg (qHBsAg) levels can identify patients with higher probability of seroclearance. The aim of our study was to evaluate qHBsAg in HBeAg-negative patients receiving NAs to predict a reduction of HBsAg levels and seroclearance. METHODS: Retrospective analysis of qHBsAg in HBeAg-negative patients before and at years 1, 3, 5, 8 and over of NAs treatment...
2017: PloS One
C D Guoynes, T C Simmons, G M Downing, S Jacob, M Solomon, K L Bales
Oxytocin (Oxt) is a neuropeptide with many functions, including modulation of social behavior(s) and anxiety. Due to its notable pro-social effects, it has been proposed as a treatment in the management of neuropsychiatric disorders, such as autism spectrum disorder (ASD), schizophrenia, and social anxiety; however, effects of long-term daily treatment are still being explored. Previously, we have shown that in male prairie voles (Microtus ochrogaster) exposure to Oxt during the peri-adolescent period impaired adult pair bonding in a dose-dependent fashion...
November 25, 2017: Neuroscience
Xu-Xiao Chen, Jian-Wen Cheng, Ao Huang, Xin Zhang, Jian Wang, Jia Fan, Jian Zhou, Xin-Rong Yang
Background and aim: Studies suggest that antiviral therapy performed after curative resection improves the postoperative prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the evidence has been contradictory. The aim of this meta-analysis was to assess the effect of antiviral therapy with nucleoside analogs (NAs) after curative resection on the long-term postoperative survival of patients with HBV-related HCC. Materials and methods: MEDLINE, PubMed, Embase, and Cochrane Library were systematically searched up to August 2017 with no limits...
2017: OncoTargets and Therapy
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