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https://www.readbyqxmd.com/read/29466781/an-active-learning-representative-subset-selection-method-using-net-analyte-signal
#1
Zhonghai He, Zhenhe Ma, Jingmin Luan, Xi Cai
To guarantee accurate predictions, representative samples are needed when building a calibration model for spectroscopic measurements. However, in general, it is not known whether a sample is representative prior to measuring its concentration, which is both time-consuming and expensive. In this paper, a method to determine whether a sample should be selected into a calibration set is presented. The selection is based on the difference of Euclidean norm of net analyte signal (NAS) vector between the candidate and existing samples...
February 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29463024/overexpression-of-the-vitronectin-v10-subunit-in-patients-with-nonalcoholic-steatohepatitis-implications-for-noninvasive-diagnosis-of-nash
#2
Maria Del Ben, Diletta Overi, Licia Polimeni, Guido Carpino, Giancarlo Labbadia, Francesco Baratta, Daniele Pastori, Valeria Noce, Eugenio Gaudio, Francesco Angelico, Carmine Mancone
Nonalcoholic steatohepatitis (NASH) is the critical stage of nonalcoholic fatty liver disease (NAFLD). The persistence of necroinflammatory lesions and fibrogenesis in NASH is the leading cause of liver cirrhosis and, ultimately, hepatocellular carcinoma. To date, the histological examination of liver biopsies, albeit invasive, remains the means to distinguish NASH from simple steatosis (NAFL). Therefore, a noninvasive diagnosis by serum biomarkers is eagerly needed. Here, by a proteomic approach, we analysed the soluble low-molecular-weight protein fragments flushed out from the liver tissue of NAFL and NASH patients...
February 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29460560/-isolation-precautions-in-multi-drug-resistent-infections-and-nursing-workload-in-a-general-intensive-care-unit
#3
Stefano Elli, Luigi Cannizzo, Giuseppe Foti, Roberto Fumagalli, Alberto Lucchini
BACKGROUND: Critically ill patients in ICU are exposed to high risk of hospital acquired infections. In recent years, the multi drug resistant microorganisms (MDR) represent the most worrying epidemiological problem. AIM: The aim of this study is to evaluate the relationship between isolation precautions and nursing workload. METHODS: We studied patients who had an infection by MDR, subject to isolation precautions, and measured their NAS score during stay in ICU...
October 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29457045/efficacy-of-endoscopic-retrograde-cholangiopancreatography-in-the-treatment-of-biliary-complications-following-liver-transplant-10-years-of-a-single-centre-experience
#4
Ana Rita Alves, Dário Gomes, Emanuel Furtado, Luís Tomé
Background and Aims: Biliary tract complications following liver transplant remain an important source of morbidity and mortality. Endoscopic retrograde cholangiopancreatography (ERCP) has become a common therapeutic option before other invasive procedures. The aim of this study was to evaluate ERCP efficacy in managing this type of complications. Methods: Retrospective study of all patients who underwent therapeutic ERCP due to post-liver transplant biliary complications between September 2005 and September 2015, at a deceased donor liver transplantation centre...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453915/efficacy-of-nucleoside-analogues-for-hepatitis-b-virus-related-liver-failure-a-network-meta-analysis
#5
Jian Wu, Fang Yin, Xinmin Zhou
The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453779/mitochondrial-cytochrome-p450-cyp-1b1-is-responsible-for-melatonin-induced-apoptosis-in-neural-cancer-cells
#6
Zhenlong Yu, Xiangge Tian, Yuling Peng, Zheng Sun, Chao Wang, Ning Tang, Bin Li, Yuqing Jian, Wei Wang, Xiaokui Huo, Xiaochi Ma
Melatonin is an endogenous indoleamine with a wide range of biological functions in the various organisms from bacteria to mammals. Evidence indicates that melatonin facilitates apoptosis in cancer cells and enhances the anti-tumor activity of chemotherapy in animals and clinical studies. However, the melatonin metabolism and the key metabolic targets in cancer cells still remain unknown. In this study, U118 and SH-SY5Y tumor cell lines were used to investigate the metabolic pathways of melatonin in cancer cells...
February 17, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29452403/mechanisms-controlling-nucleic-acid-sensing-toll-like-receptors
#7
Kensuke Miyake, Takuma Shibata, Umeharu Ohto, Toshiyuki Shimizu, Shin-Ichiroh Saitoh, Ryutaro Fukui, Yusuke Murakami
Nucleic acid (NA)-sensing Toll-like receptors (TLRs) respond to DNA/RNA derived from pathogens and dead cells. Structural studies have revealed a variety of molecular mechanisms by which TLRs sense NAs. Double-stranded RNA and single-stranded DNA directly bind to TLR3 and TLR9, respectively, whereas TLR7 and 8 bind to nucleosides and oligoribonucleotides derived from RNAs. Activation of ligand-bound TLRs is influenced by the functional status of TLRs. Proteolytic cleavage of NA-sensing TLRs enables ligand-dependent TLR dimerization...
February 14, 2018: International Immunology
https://www.readbyqxmd.com/read/29451182/host-genetic-factors-in-predicting-response-status-in-chronic-hepatitis-b-patients-discontinuing-nucleos-t-ide-analogs
#8
Tao Li, Feng Liu, Lixin Zhang, Qian Ye, Xiaoping Fan, Yan Xue, Lei Wang
Background/Aims: The optimal duration of nucleos(t)ide analogs (NAs) therapy in chronic hepatitis B (CHB) patients remains unsatisfactory. Previous studies have confirmed the important role of host genetic factors in determining the outcome of HBV infection. This study tries to determine the role of host genetic factors in predicting response status in CHB patients discontinuing NAs according to stringent cessation criteria. Patients and Methods: Participating patients came from a prospective NAs- discontinuation cohort since June 1999...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29450918/nanoalloy-materials-for-chemical-catalysis
#9
REVIEW
Hao Fang, Jinhu Yang, Ming Wen, Qingsheng Wu
Nanoalloys (NAs), which are distinctly different from bulk alloys or single metals, take on intrinsic features including tunable components and ratios, variable constructions, reconfigurable electronic structures, and optimizable performances, which endow NAs with fascinating prospects in the catalysis field. Here, the focus is on NA materials for chemical catalysis (except photocatalysis or electrocatalysis). In terms of composition, NA systems are divided into three groups, noble metal, base metal, and noble/base metal mixed NAs...
February 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29449090/clinical-and-molecular-characteristics-and-burden-of-kidney-cancer-among-hispanics-and-native-americans-steps-toward-precision-medicine
#10
Ken Batai, Andrew Bergersen, Elinora Price, Kieran Hynes, Nathan A Ellis, Benjamin R Lee
Cancer disparities in Native Americans (NAs) and Hispanic Americans (HAs) vary significantly in terms of cancer incidence and mortality rates across geographic regions. This review reports that kidney and renal pelvis cancers are unevenly affecting HAs and NAs compared to European Americans of non-Hispanic origin, and that currently there is significant need for improved data and reporting to be able to advance toward genomic-based precision medicine for the assessment of such cancers in these medically underserved populations...
February 12, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29445541/multiple-dimensions-of-excessive-daytime-sleepiness
#11
Sasha Smith, Jennifer Rossdale, Yaseen Serry, Anisha Sekaran, Panagis Drakatos, Joerg Steier
Background: In this study we investigated subjective measures of sleepiness and related our findings to dimensions of affect, fatigue, emotion, mood and quality of life based on a hypothetical multidimensional model of sleepiness. Methods: Patients referred to a sleep clinic were assessed regarding their excessive daytime sleepiness (EDS), sleep complaints, routine and symptoms. Age, gender and body mass index (BMI), the Epworth Sleepiness Scale (ESS), the Stanford Sleepiness Scale (SSS), the Samn-Perelli fatigue Scale (SPS), the Global Vigor and Affect Scale (GVS and GAS, respectively), the Hospital Anxiety and Depression Scale (HADS-A and HADS-D, respectively), and the Positive and Negative Affect Schedule (PAS and NAS, respectively) scores were recorded...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29443414/neonatal-outcomes-after-fetal-exposure-to-methadone-and-buprenorphine-national-registry-studies-from-the-czech-republic-and-norway
#12
Blanka Nechanská, Viktor Mravčík, Svetlana Skurtveit, Ingunn Olea Lund, Roman Gabrhelík, Anders Engeland, Marte Handal
BACKGROUND AND AIMS: Opioid maintenance treatment (OMT) is recommended to opioid dependent females during pregnancy. However, it is not clear which medication should be preferred. We aimed to compare neonatal outcomes after prenatal exposure to methadone (M) and buprenorphine (B) in two European countries. DESIGN: Nationwide register-based cohort study using personalized IDs assigned to all citizens for data linkage. SETTING: The Czech Republic (2000-2014) and Norway (2004-2013)...
February 14, 2018: Addiction
https://www.readbyqxmd.com/read/29436353/feeding-infants-with-neonatal-abstinence-syndrome-finding-the-sweet-spot
#13
Denise J Maguire, Emily Shaffer-Hudkins, Kathleen Armstrong, Leah Clark
PURPOSE: The purpose of this study is to learn how caregivers who are expert in feeding infants with neonatal abstinence syndrome (NAS) successfully feed these infants during withdrawal. DESIGN/SAMPLE: Focus group methodology was used to gather information from self-identified experts from three large regional NICUs. Twelve NICU nurses and speech therapists participated in open-ended, recorded discussions. Detailed flip chart notes were taken, reviewed, and verified by the participants before the group ended...
January 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29428413/treating-neonatal-abstinence-syndrome-in-a-rural-hospital-lessons-learned
#14
Anne Gadomski, Moira Riley, Katherine Ramiza, Lauren Onofrey, Ruth Zinkievich, Nicole Krupa, Melissa Scribani
OBJECTIVE: Our level I nursery and pediatric unit in a rural hospital adopted a family-centered, symptom-based oral morphine weaning protocol for Neonatal Abstinence Syndrome (NAS) in 2009. Length of stay (LOS), treatment duration (TD) and hospital charges for infants treated for NAS were then compared to published data in neonatal intensive care units (NICUs) nationwide. METHODS: The electronic medical records (EMRs) of infants born 1/1/11 to 4/1/17 whose discharge diagnosis included an ICD9 or ICD10 code for NAS or prenatal drug exposure were paired with maternal EMR and reviewed...
February 8, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29426216/bioreactors-for-oil-sands-process-affected-water-ospw-treatment-a-critical-review
#15
REVIEW
Jinkai Xue, Chunkai Huang, Yanyan Zhang, Yang Liu, Mohamed Gamal El-Din
Canada has the world's largest oil sands reservoirs. Surface mining and subsequent caustic hot water extraction of bitumen lead to an enormous quantity of tailings (volumetric ratio bitumen:water=9:1). Due to the zero-discharge approach and the persistency of the complex matrix, oil producers are storing oil sands tailings in vast ponds in Northern Alberta. Oil sands tailings are comprised of sand, clay and process-affected water (OSPW). OSPW contains an extremely complex matrix of organic contaminants (e.g...
February 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29423822/barriers-to-the-medication-error-reporting-process-within-the-irish-national-ambulance-service-a-focus-group-study
#16
Eamonn Byrne, Gerard Bury
BACKGROUND: Incident reporting is vital to identifying pre-hospital medication safety issues because literature suggests that the majority of errors pre-hospital are self-identified. In 2016, the National Ambulance Service (NAS) reported 11 medication errors to the national body with responsibility for risk management and insurance cover. The Health Information and Quality Authority in 2014 stated that reporting of clinical incidents, of which medication errors are a subset, was not felt to be representative of the actual events occurring...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29422861/the-turkish-medicines-and-medical-devices-agency-comparison-of-its-registration-process-with-australia-canada-saudi-arabia-and-singapore
#17
Emel Mashaki Ceyhan, Hakki Gürsöz, Ali Alkan, Hacer Coşkun, Oğuzhan Koyuncu, Stuart Walker
Introduction: Regulatory agency comparisons can be of more value and facilitate improvements if conducted among countries with common challenges and similar health agency characteristics. A study was conducted to compare the registration review model used by the Turkish Medicines and Medical Devices Agency (Türkiye Ilaç ve Tibbi Cihaz Kurumu; TITCK) with those of four similar-sized regulatory agencies to identify areas of strength and those requiring further improvement within the TITCK in relation to the review process as well as to assess the level of adherence to good review practices (GRevP) in order to facilitate the TITCK progress toward agency goals...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29422149/nurses-and-nursing-assistants-decision-making-regarding-use-of-safe-patient-handling-and-mobility-technology-a-qualitative-study
#18
Mary Louise Kanaskie, Cynthia Snyder
AIM: This study explored decision-making regarding use of safe patient handling and mobility (SPHM) technology among registered nurses (RN) and nursing assistants (NA). BACKGROUND: Lifting injuries are common among healthcare workers. Despite development of standards for SPHM, the introduction of regulation for monitoring access to SPHM technology, and implementation of education programs and process improvements, threat of injury remains a concern. Although access to SPHM equipment is associated with decreased workplace injuries, access alone does not guarantee use...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29417369/mental-health-of-mothers-of-infants-with-neonatal-abstinence-syndrome-and-prenatal-opioid-exposure
#19
Laura J Faherty, Meredith Matone, Molly Passarella, Scott Lorch
BACKGROUND: The prevalence of opioid use during pregnancy is increasing. Two downstream effects are neonatal abstinence syndrome (NAS), a postnatal withdrawal syndrome, and long-term prenatal opioid exposure (LTPOE) without documented withdrawal symptoms in the infant. Mental health characteristics of mothers of infants with NAS and LTPOE have not been described. METHODS: Using linked maternal and infant Medicaid claims and birth certificate data, we analyzed 15,571 infants born to Medicaid-insured women 15-24 years old in a mid-Atlantic city from 2007 to 2010...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29413437/prenatal-exposure-to-methadone-or-buprenorphine-early-childhood-developmental-outcomes
#20
Karol Kaltenbach, Kevin E O'Grady, Sarah H Heil, Amy L Salisbury, Mara G Coyle, Gabriele Fischer, Peter R Martin, Susan Stine, Hendrée E Jones
BACKGROUND: Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy. However, the literature on the relationship between longer-term effects of prenatal exposure to these medications and childhood development is both spare and inconsistent. METHODS: Participants were 96 children and their mothers who participated in MOTHER, a randomized controlled trial of opioid-agonist pharmacotherapy during pregnancy. The present study examined child growth parameters, cognition, language abilities, sensory processing, and temperament from 0 to 36 months of the child's life...
February 1, 2018: Drug and Alcohol Dependence
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