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https://www.readbyqxmd.com/read/27907816/nucleic-acid-sensing-tlrs-trafficking-and-regulation
#1
REVIEW
Olivia Majer, Bo Liu, Gregory M Barton
Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign-derived and host-derived nucleic acid ligands. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition...
November 28, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27901222/workload-and-associated-factors-a-study-in-maritime-port-in-brazil
#2
Marta Regina Cezar-Vaz, Clarice Alves Bonow, Marlise Capa Verde de Almeida, Cynthia Fontella Sant'Anna, Leticia Silveira Cardoso
Objective: to identify the effect of the mental, physical, temporal, performance, total effort and frustration demands in the overall workload, and in the same way analyze the global burden of port labor and associated factors that contribute most to their decrease or increase. Method: a cross-sectional, quantitative study, developed with 232 dock workers. For data collection, a structured questionnaire with descriptive, occupational, smoking and illicit drug use variables was applied, as well as variables on the load on the tasks undertaken at work, based on the questionnaire NASA Task Load Index...
November 28, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27901033/impact-of-dietary-glycemic-challenge-on-fuel-partitioning
#3
REVIEW
A Bosy-Westphal, F Hägele, A Nas
The 'carbohydrate-insulin theory of obesity' is used to justify popular health claims stating that carbohydrates make you fat or a high glycemic load and consumption of sugar-sweetened beverages (SSBs) and breakfast skipping increase fat gain. According to this theory, the elevated postprandial insulin secretion to a high glycemic challenge is blamed as a causal mechanism by directing nutrients away from oxidation in muscle towards storage in adipose tissue. Scientific evidence is however largely disagreeing with an adverse effect of postprandial hyperinsulinemia on fuel partitioning...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27898334/relative-contribution-of-ammonia-oxidizing-bacteria-and-other-members-of-nitrifying-activated-sludge-communities-to-micropollutant-biotransformation
#4
Yujie Men, Stefan Achermann, Damian E Helbling, David R Johnson, Kathrin Fenner
Improved micropollutant (MP) biotransformation during biological wastewater treatment has been associated with high ammonia oxidation activities, suggesting co-metabolic biotransformation by ammonia oxidizing bacteria as an underlying mechanism. The goal of this study was to clarify the contribution of ammonia oxidizing bacteria to increased MP degradation in nitrifying activated sludge (NAS) communities using a series of inhibition experiments. To this end, we treated a NAS community with two different ammonia oxidation inhibitors, namely octyne (OCT), a mechanistic inhibitor that covalently binds to ammonia monooxygenases, and allylthiourea (ATU), a copper chelator that depletes copper ions from the active center of ammonia monooxygenases...
November 22, 2016: Water Research
https://www.readbyqxmd.com/read/27889436/wide-variation-found-in-care-of-opioid-exposed-newborns
#5
Debra L Bogen, Bonny L Whalen, Laura R Kair, Mark Vining, Beth A King
OBJECTIVE: Standardized practices for the management of neonatal abstinence syndrome (NAS) are associated with shorter lengths of stay, but optimal protocols are not established. We sought to identify practice variations for newborns with in utero chronic opioid exposure among hospitals in the Better Outcomes Through Research for Newborns (BORN) network. METHODS: Nursery site leaders completed a survey about hospitals' policies and practices regarding care for infants with chronic opioid exposure (≥3 weeks)...
November 23, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27888284/attenuation-of-the-anxiogenic-effects-of-cocaine-by-5-ht1b-autoreceptor-stimulation-in-the-bed-nucleus-of-the-stria-terminalis-of-rats
#6
Adam K Klein, Michael A Brito, Sayeh Akhavan, Dylan R Flanagan, Nikki Le, Tatum Ohana, Anand S Patil, Erin M Purvis, Carl Provenzano, Alex Wei, Lucy Zhou, Aaron Ettenberg
RATIONALE: Cocaine produces significant aversive/anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of anxiogenic states. OBJECTIVES: The present study examined the contribution of 5-HT signaling within the BNST to the anxiogenic effects of cocaine as measured in a runway model of drug self-administration...
November 25, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27886650/the-relationship-between-gestational-age-and-the-severity-of-neonatal-abstinence-syndrome
#7
Kelly S Gibson, Ms Sydney Stark, Deepak Kumar, Jennifer L Bailit
BACKGROUND AND AIMS: The relationship between gestational age at delivery and the severity of neonatal abstinence syndrome (NAS) is poorly understood. Our objective was to compare the length of pharmacotherapy and hospital stay among opioid exposed infants born during the late preterm, early term, full term, and late term periods. DESIGN: Retrospective cohort study of infants affected by NAS SETTING: MetroHealth Medical Center in Cleveland, Ohio, USA: an urban tertiary care hospital serving as the referral center for opioid dependency in pregnancy with a level III neonatal intensive care unit PARTICIPANTS: All deliveries complicated by maternal opioid exposure from January 2000 to October 2014; 403 were eligible to be included (n = 102 Late Preterm, 34-36weeks (LP), n = 158 Early Term, 37-38weeks (ET), n = 122 Full Term, 39-40weeks (FT), n = 21 Late Term, ≥41 weeks (LT))...
November 25, 2016: Addiction
https://www.readbyqxmd.com/read/27882776/benefits-of-long-term-therapy-with-nucleos-t-ide-analogues-in-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-b
#8
Lai Wei, Jia-Horng Kao
OBJECTIVE: To assess the benefits of long-term nucleos(t)ide analogue (NA) therapy in reducing the severity and progression of liver disease in treatment-naïve patients with chronic hepatitis B (CHB). SCOPE: As complications of CHB, such as hepatic decompensation and hepatocellular carcinoma (HCC), take a long time to develop in patients with less advanced disease, the long-term benefits of NA therapy in such patients are more difficult to prove than short- or medium-term benefits...
November 24, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27878469/genetic-diversity-and-population-structure-of-nuphar-submersa-nymphaeaceae-a-critically-endangered-aquatic-plant-endemic-to-japan-and-implications-for-its-conservation
#9
Takashi Shiga, Masashi Yokogawa, Shingo Kaneko, Yuji Isagi
Nuphar submersa (Nymphaeaceae) is a critically endangered freshwater macrophyte indigenous to central Japan, with only four small extant populations represented across its entire range. We investigated the genotypic and genetic diversity as well as the genetic structure of all extant individuals of N. submersa based on analysis of 15 microsatellite loci. Among 278 individual ramets, 52 multilocus genotypes were detected: 30 genotypes in Nikko City (NIK), 18 in Nasukarasuyama City (NAS), 3 in Mooka City (MOK), and 1 in Sakura City (SAK)...
November 22, 2016: Journal of Plant Research
https://www.readbyqxmd.com/read/27878221/the-use-of-a-metronome-during-cardiopulmonary-resuscitation-in-the-emergency-room-of-a-university-hospital
#10
Renata Maria de Oliveira Botelho, Cássia Regina Vancini Campanharo, Maria Carolina Barbosa Teixeira Lopes, Meiry Fernanda Pinto Okuno, Aécio Flávio Teixeira de Góis, Ruth Ester Assayag Batista
Objective: to compare the rate of return of spontaneous circulation (ROSC) and death after cardiac arrest, with and without the use of a metronome during cardiopulmonary resuscitation (CPR). Method: case-control study nested in a cohort study including 285 adults who experienced cardiac arrest and received CPR in an emergency service. Data were collected using In-hospital Utstein Style. The control group (n=60) was selected by matching patients considering their neurological condition before cardiac arrest, the immediate cause, initial arrest rhythm, whether epinephrine was used, and the duration of CPR...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27878220/diagnosis-of-compliance-of-health-care-product-processing-in-primary-health-care
#11
Camila Eugenia Roseira, Darlyani Mariano da Silva, Isis Pienta Batista Dias Passos, Fabiana Souza Orlandi, Maria Clara Padoveze, Rosely Moralez de Figueiredo
Objective: identify the compliance of health care product processing in Primary Health Care and assess possible differences in the compliance among the services characterized as Primary Health Care Service and Family Health Service. Method: quantitative, observational, descriptive and inferential study with the application of structure, process and outcome indicators of the health care product processing at ten services in an interior city of the State of São Paulo - Brazil...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27876117/neonatal-abstinence-syndrome-and-the-gastrointestinal-tract
#12
Denise Maguire, Maureen Gröer
Development of a healthy gut microbiome is essential in newborns to establish immunity and protection from pathogens. Recent studies suggest that infants who develop dysbiosis may be at risk for lifelong adverse health consequences. Exposure to opioid drugs during pregnancy is a factor of potential importance for microbiome health that has not yet been investigated. Since these infants are born after an entire gestation exposed to mu opioid receptor agonists and have severe gastrointestinal and neurological symptoms, we hypothesize that these infants are at risk for dysbiosis...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27871514/cost-impact-of-unexpected-disposition-after-orthopedic-ambulatory-surgery-associated-with-category-of-anesthesia-provider
#13
Robert L Ohsfeldt, Thomas R Miller, John E Schneider, Cara M Scheibling
STUDY OBJECTIVE: To provide estimates of the costs and health outcomes implications of the excess risk of unexpected disposition for nurse anesthetist (NA) procedures. DESIGN: A projection model was used to apply estimates of costs and health outcomes associated with the excess risk of unexpected disposition for NAs reported in a recent study. SETTING: Ambulatory and inpatient surgery. PATIENTS: Base-case model parameters were based on estimates taken from peer-reviewed publications when available, or from other sources including data for all hospital stays in the United States in 2013 from the Healthcare Cost and Utilization Project Web site...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27867167/evaluation-of-fat-quantification-in-the-liver-using-dual-energy-ct
#14
Shunsuke Itaya, Takeshi Matsui, Tetsuya Kamiyama, Hiroyuki Yoshino
BACKGROUND AND PURPOSE: Recently, the number of patients with nonalcoholic fatty liver disease (NAFLD) has been increasing, and some of them progresses to cirrhosis and hepatocellular carcinoma. Dual energy CT allows the discrimination of substance using monochromatic image (MI), and steatosis exhibit specifically the CT value of each energy level. The purpose is to evaluate the fat quantification in the liver using spectral HU curve and CT value compare to a conventional image diagnosis...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27863135/a-new-roadmap-for-the-journey-from-internist-to-rheumatologist
#15
Lisa G Criscione-Schreiber, Calvin R Brown, Kenneth S O'Rourke, Howard A Fuchs, Chaim Putterman, Irene J Tan, Joanne Valeriano-Marcet, Evelyn Hsieh, Sarah Zirkle, Marcy B Bolster
OBJECTIVE: Measurement is necessary to gauge improvement. U.S. training programs have not previously used shared standards to assess trainees' mastery of the knowledge, skills, and attitudes necessary to practice rheumatology competently. In 2014, the Accreditation Council for Graduate Medical Education (ACGME) Next Accreditation System (NAS) began requiring semi-annual evaluation of all medicine subspecialty fellows on 23 Internal Medicine Subspecialty Reporting Milestones. Since these Reporting Milestones are not subspecialty-specific, Rheumatology Curricular Milestones were needed to guide rheumatology fellowship training programs and fellows on the training journey from Internist to Rheumatologist...
November 11, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27862721/efficacy-and-safety-of-tenofovir-disoproxil-fumarate-rescue-therapy-for-chronic-hepatitis-b-patients-who-failed-other-nucleos-t-ide-analogues
#16
Hiromitsu Kumada, Kazuhiko Koike, Kazuaki Suyama, Hiroshi Ito, Hiroshi Itoh, Wataru Sugiura
OBJECTIVE: Acquisition of nucleos(t)ide analogue (NA) inhibitors resistance is critical in successful chronic hepatitis B treatment. As the pattern of tenofovir disoproxil fumarate (TDF) resistance mutations differs from that of other antiviral drugs, we sought to clarify the salvaging potential of TDF in HBV patients who are poor responders or resistant to other NAs. MATERIALS AND METHOD: A prospective, multi-center, one-arm, open-label study was conducted from December 2011 to October 2014...
November 15, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27857392/temperature-mapping-using-molecular-diffusion-based-fluorescence-thermometry-via-simultaneous-imaging-of-two-numerical-apertures
#17
Chen Chen, Zhidong Du, Jicheng Wang, Liang Pan
We report a new optical technique to map two-dimensional temperature distributions in liquid solutions based on the thermal motion of fluorescent molecules. We simultaneously capture the fluorescence images of different numerical apertures (NAs) to resolve the temperature-dependent orientations of emission dipoles. In this work, we use two numerical apertures (2NA) prove the concept. This 2NA technique is robust against the intensity variations caused by photobleaching, unsteady illumination and nonuniform molecule distribution...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27851786/calcium-reduces-liver-injury-in-mice-on-a-high-fat-diet-alterations-in-microbial-and-bile-acid-profiles
#18
Muhammad Nadeem Aslam, Christine M Bassis, Li Zhang, Sameer Zaidi, James Varani, Ingrid L Bergin
A high-fat "Western-style" diet (HFWD) promotes obesity-related conditions including non-alcoholic steatohepatitis (NASH), the histologic manifestation of non-alcoholic fatty liver disease (NAFLD). In addition to high saturated fat and processed carbohydrates, the typical HFWD is deficient in calcium. Calcium-deficiency is an independent risk factor for many conditions associated with the Western-style diet. However, calcium has not been widely evaluated in the context of NAFLD. The goal of the present study was to determine if dietary calcium supplementation could protect mice fed a HFWD from NAFLD, specifically by decreasing non-alcoholic steatohepatitis (NASH) and its down-stream consequences...
2016: PloS One
https://www.readbyqxmd.com/read/27849292/health-policy-on-the-pages-of-revista-de-sa%C3%A3%C2%BAde-p%C3%A3%C2%BAblica
#19
Aylene Bousquat, Oswaldo Yoshimi Tanaka
We carried out a narrative review of the scientific production in the area of Policy, Planning and Management in Revista de Saúde Pública (RSP), between 1967 and 2015. All the fascicles of RSP, in the period, were accessed via SciELO platform, which provides all articles online. We selected and classified the articles according to the main topics of scientific production in the area of Policy, Planning and Management. Revista de Saúde Pública has published 343 articles on this subject, with significant growth in the last two decades...
November 10, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27849291/revista-de-sa%C3%A3%C2%BAde-p%C3%A3%C2%BAblica-in-scientific-publications-on-violence-and-health-1967-2015
#20
Lilia Blima Schraiber, Claudia Barros, Ana Flávia Pires Lucas d'Oliveira, Maria Fernanda Tourinho Peres
This article retrieved the publications from the Revista de Saúde Pública journal (from 1967 to 2015) on violence and health, on the SciELO and PubMed bases, by searching for the terms "violence", "suicide", "aggression", "bullying", and "external causes", registered in any part of the text. We found 130 articles (the first one published in 1974). We observed: increase of publications over time, with decrease in the last five years; similar production volume in lethal and non-lethal violence; later publication of the latter; few studies in qualitative research; mostly descriptive production; and visualization of the problem more by the acts than by contexts or motivations and aggressors...
November 10, 2016: Revista de Saúde Pública
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