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https://www.readbyqxmd.com/read/29932412/attitudes-of-nephrologists-towards-intensified-hemodialysis
#1
Julia Thumfart, Steffen Wagner, Anuradha Jayanti, Dominik Müller, Wolfgang Pommer
AIMS: Intensified hemodialysis (HD) programs have been developed to overcome the shortcomings of conventional HD. However, there are no data on the implementation of intensified HD programs into routine care. Therefore, we investigated the attitude of nephrologists towards intensified HD, its penetrance into clinical practice, and barriers to implementation. MATERIALS AND METHODS: We performed an online survey within the German Society of Nephrology on the beliefs and attitudes towards intensified HD...
June 22, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29929485/practice-patterns-in-transitioning-patients-from-chronic-kidney-disease-to-dialysis-a-survey-of-united-states-nephrologists
#2
Mary C Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos, Moro Salifu
BACKGROUND: There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patients to dialysis. METHODS: We designed an electronic survey with 39 questions and sent it to a database of practicing nephrologists at the National Kidney Foundation. Factors that were important for transitioning a patient to hemodialysis were evaluated, including medication changes on dialysis initiation, dry weight and dialysis prescription...
June 22, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29923672/association-of-preoperative-mean-arterial-pressure-with-the-primary-failure-of-brescia-cimino-arteriovenous-fistula-within-the-first-7-days-following-surgery-in-hemodialysis-patients
#3
Yan Yan, Xiaoxia Su, Jie Zheng, Li Zhang, Liu Yang, Qing Jiang, Qinkai Chen
This retrospective study included 1051 patients with end-stage kidney disease and Brescia-Cimino arteriovenous fistula (AVF) (excluding pre-dialysis patients), and aimed to investigate the role of blood pressure in AVF primary failure. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured twice daily for 3 days before surgery. The success (N = 1010) and failure (N = 41) groups were based on AVF primary failure within 7 days of surgery. The cephalic vein was larger and the preoperative mean arterial pressure (MAP) was higher in the success group compared with the failure group (P < 0...
June 20, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29921575/shen-shuai-ning-granule-decreased-serum-concentrations-of-indoxyl-sulfate-in-uremic-patients-undergoing-peritoneal-dialysis
#4
Xujiao Chen, Shouhong Gao, Mengna Ruan, Sixiu Chen, Jing Xu, Xiaohong Xing, Xiaohong Pan, Changlin Mei, Zhiguo Mao
Background Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning(SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. Methods We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29898584/factors-influencing-weaning-from-mechanical-ventilation-in-neurological-and-neurosurgical-early-rehabilitation-patients-results-from-a-german-multi-center-study
#5
Simone B Schmidt, Melanie Boltzmann, Markus Bertram, Christoph Bucka, Michael Hartwich, Michael Jöbges, Guido Ketter, Bernd Leineweber, Marion Mertl-Rötzer, Dennis A Nowak, Thomas Platz, Klaus Scheidtmann, Randall Thomas, Friedrich von Rosen, Claus W Wallesch, Hartwig Woldag, Peter Peschel, Jan Mehrholz, Marcus Pohl, Jens D Rollnik
BACKGROUND: Studies analyzing risk factors of weaning failure in neurological and neurosurgical early rehabilitation (NNER) patients are rare. AIM: The aim of this study was to identify clinical factors influencing the weaning of NNER patients. DESIGN: An observational, retrospective data analysis of a German multi-center study was performed. POPULATION: Inpatient ventilated NNER patients (n=192) were enrolled in the study...
June 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29882003/prevalence-and-risk-factors-for-hypercalcemia-among-non-dialysis-patients-with-chronic-kidney-disease-mineral-and-bone-disorder
#6
Jun Jie Benjamin Seng, Ying Lin Cheryl Tan, Rou Wei Lim, Hui Ting Sarah Ng, Puay Hoon Lee, Jiunn Wong
PURPOSE: To examine the prevalence and risk factors for hypercalcemia among non-dialysis chronic kidney disease (CKD) patients with mineral and bone disorder (MBD). METHODS: A retrospective cohort study was conducted in Singapore General Hospital, involving all CKD stage 4 and 5 pre-dialysis patients who were on treatment for MBD in June 2016. Each patient was followed up for 1 year and screened for hypercalcemia episodes. Mild, moderate and severe hypercalcemia were defined as corrected calcium of 2...
June 7, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29871774/high-dose-intravenous-immunoglobulin-treatment-of-polyomavirus-nephropathy-developing-after-t-cell-mediated-rejection-treatment-a-case-report
#7
S D Hwang, J H Lee, S W Lee, J K Kim, M-J Kim, J H Song
BACKGROUND: Reactivation of BK polyomavirus causes destructive virus allograft nephropathy; however, treatment options are limited. Herein, we report a case in which a patient with T cell-mediated rejection was treated with steroid therapy. The patient subsequently developed BK viremia and was successfully treated by using intravenous immunoglobulin (IVIG) after failing to respond to conventional treatment. CASE PRESENTATION: A 54-year-old man had been undergoing peritoneal dialysis for 3 years before kidney transplantation...
June 2, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29861057/targeting-toll-like-receptors-with-soluble-toll-like-receptor-2-prevents-peritoneal-dialysis-solution-induced-fibrosis
#8
Anne-Catherine Raby, Guadalupe T González-Mateo, Aled Williams, Nicholas Topley, Donald Fraser, Manuel López-Cabrera, Mario O Labéta
Peritoneal membrane failure due to fibrosis limits the use of peritoneal dialysis (PD). Peritoneal fibrosis may potentially be induced by sterile inflammation caused by ongoing cellular stress due to prolonged exposure to PD solutions (PDS). Effective therapies to prevent this process remain to be developed. Toll-like receptors (TLRs) mediate sterile inflammation by recognizing damage-associated molecular patterns (DAMPs) released by cellular stress. We evaluated the involvement of TLRs and DAMPs in PDS-induced fibrosis models and the therapeutic potential of TLR-DAMP targeting for preventing fibrosis...
May 31, 2018: Kidney International
https://www.readbyqxmd.com/read/29849020/adoption-and-application-in-italy-of-the-principal-guidelines-and-international-recommendations-on-venous-access
#9
Rosario Spina, Baudolino Mussa, Lara Tollapi, Fabio Conti, Enrico Cortesi, Roberto Verna
Vascular access is the commonest invasive procedure in secondary care. Vascular access is understood as being access to the bloodstream of acute and chronic patients for diagnostic and therapeutic purposes such as blood sampling, vessel pressure monitoring, fluid infusions (blood transfusions, parenteral nutrition), pharmacological treatments (e.g. antibiotic therapies, chemotherapy, analgesic therapies) or apheresis/dialysis through catheters that may remain in the vessels for weeks or months. There is a wide variety of options available for venous access...
June 2018: Minerva Medica
https://www.readbyqxmd.com/read/29796068/discrepancies-in-measuring-bladder-volumes-with-bedside-ultrasound-and-bladder-scanning-in-the-intensive-care-unit-a-pilot-study
#10
Donna M Prentice, Carrie Sona, Brian T Wessman, Enyo A Ablordeppey, Warren Isakow, Cassandra Arroyo, Marilyn Schallom
Objective: Intensive care unit patients are at risk for catheter-associated urinary tract infection. Earlier removal of catheters may be possible with accurate measurement of bladder volume. The purpose was to compare measured bladder volumes with bedside ultrasound, bladder scanner, and urine volume. Design: Prospective correlational descriptive study. Setting: Surgical/trauma intensive care unit and medical intensive care unit. Patients: Renal dialysis patients with less than 100 ml of urine in 24 h prior to urinary catheter removal and patients with suspected catheter obstruction...
May 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29782259/-relationship-of-remodeling-of-carotid-arteries-and-left-ventricular-geometry-in-patients-with-chronic-glomerulonephritis
#11
I T Murkamilov, K A Aitbaev, A S Sarybaev, V V Fomin, I G Gordeev, Z R Rayimzhanov, N A Redjapova, F A Yusupov
PURPOSE: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage. MATERIALS AND METHODS: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR)...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29753311/peritoneal-and-systemic-responses-of-obese-type-ii-diabetic-rats-to-chronic-exposure-to-a-hyperbranched-polyglycerol-based-dialysis-solution
#12
Bo La Han, Qiunong Guan, Irina Chafeeva, Asher A Mendelson, Gerald da Roza, Richard Liggins, Jayachandran N Kizhakkedathu, Caigan Du
Metabolic syndrome (MetS) is commonly observed among peritoneal dialysis (PD) patients, and hyperbranched polyglycerol (HPG) is a promising glucose-sparing osmotic agent for PD. However, the biocompatibility of a HPG-based PD solution (HPG) in subjects with MetS has not been investigated. This study compared the local and systemic effects of a HPG solution with conventional Physioneal (PYS) and Icodextrin (ICO) PD solutions in rats with MetS. Obese type 2 diabetic ZSF1 rats received a daily intraperitoneal injection of PD solutions (10 mL) for 3 months...
May 12, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29744794/evaluation-of-risk-factors-for-vancomycin-induced-nephrotoxicity
#13
So Jin Park, Na Ri Lim, Hyo Jung Park, Jae Wook Yang, Min-Ji Kim, Kyunga Kim, Yong Won In, Young Mee Lee
Background Vancomycin is a glycopeptide antibiotic of choice for the treatment of serious infections caused by multi-resistant Gram-positive bacteria. However, vancomycin-associated nephrotoxicity (VAN) often limits its use. Previous data suggested a few risk factors of VAN, including higher mean vancomycin trough level, higher daily doses, old age, long duration of vancomycin therapy, and concomitant nephrotoxins. Objective To evaluate the incidence and risk factors of VAN and determine whether higher vancomycin trough concentrations were associated with a greater risk for VAN...
May 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29732423/predicting-critical-care-unit-level-complications-after-long-segment-fusion-procedures-for-adult-spinal-deformity
#14
Rafael De la Garza-Ramos, Jonathan Nakhla, Yaroslav Gelfand, Murray Echt, Aleka N Scoco, Merritt D Kinon, Reza Yassari
Background: To identify predictive factors for critical care unit-level complications (CCU complication) after long-segment fusion procedures for adult spinal deformity (ASD). Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database [2010-2014] was reviewed. Only adult patients who underwent fusion of 7 or more spinal levels for ASD were included. CCU complications included intraoperative arrest/infarction, ventilation >48 hours, pulmonary embolism, renal failure requiring dialysis, cardiac arrest, myocardial infarction, unplanned intubation, septic shock, stroke, coma, or new neurological deficit...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29728994/differences-in-peritoneal-response-after-exposure-to-low-gdp-bicarbonate-lactate-buffered-dialysis-solution-compared-to-conventional-dialysis-solution-in-a-uremic-mouse-model
#15
M Vila Cuenca, E D Keuning, W Talhout, N J Paauw, F J van Ittersum, P M Ter Wee, R H J Beelen, M G Vervloet, E Ferrantelli
BACKGROUND: Long-term exposure of conventional peritoneal dialysis (PD) fluid is associated with structural membrane alterations and technique failure. Previously, it has been shown that infiltrating IL-17-secreting CD4+T cells and pro-fibrotic M2 macrophages play a critical role in the PD-induced pathogenesis. Although more biocompatible PD solutions are recognized to better preserve the peritoneal membrane integrity, the impact of these fluids on the composition of the peritoneal cell infiltrate is unknown...
June 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29725639/dialysis-case-volume-associated-with-in-hospital-mortality-in-maintenance-dialysis-patients
#16
Shintaro Mandai, Hidehiko Sato, Soichiro Iimori, Shotaro Naito, Takayasu Mori, Daiei Takahashi, Moko Zeniya, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai
Introduction: Accumulating evidence suggests that a large hospital volume (HV) is associated with favorable outcomes in various diseases or surgical procedures. The aim of this study is to clarify the correlation of HV and dialysis case volume (DCV) with in-hospital death in patients on maintenance dialysis. Methods: The study cohort was derived from the Diagnosis Procedure Combination database, a national inpatient database in Japan, from 2012 to 2014. We included 382,689 admissions of maintenance dialysis patients over the age of 20 years in the analysis...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29698409/heparin-free-dialysis-in-critically-sick-children-using-sustained-low-efficiency-dialysis-sledd-f-a-new-hybrid-therapy-for-dialysis-in-developing-world
#17
Sidharth Kumar Sethi, Shyam B Bansal, Anshika Khare, Maninder Dhaliwal, Veena Raghunathan, Nikita Wadhwani, Ashish Nandwani, Dinesh Kumar Yadav, Amit Kumar Mahapatra, Rupesh Raina
BACKGROUND: In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two recent studies from Taiwan (n = 11) and India (n = 68) showed benefits of SLED in critically sick children. AIMS AND OBJECTIVES: The objective of the study was to look at the feasibility and tolerability of sustained low efficiency daily dialysis-filtration [SLEDD-f] in critically sick pediatric patients...
2018: PloS One
https://www.readbyqxmd.com/read/29694445/survival-predictors-in-anuric-patients-on-peritoneal-dialysis-a-prospective-multicenter-propensity-score-matched-cohort-study
#18
Ja-Yong Park, Jang-Hee Cho, Hye Min Jang, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim
Prevalent anuric peritoneal dialysis (PD) patients usually have higher mortality than PD patients with residual urine volume. We aimed to evaluate the predictors of survival in anuric PD patients. Anuric PD patients (n = 505, <100 mL of daily urine) enrolled in Korean nationwide prospective cohort were analyzed. Survived and non-survived anuric PD patients were compared by propensity score matching analysis with a ratio of two to one. The propensity method was used to adjust for patient age, dialysis duration, and presence of diabetes...
2018: PloS One
https://www.readbyqxmd.com/read/29691259/transdermal-estradiol-for-the-management-of-refractory-uremic-bleeding
#19
Jimmy Gonzalez, Samantha Bryant, Evelyn R Hermes-DeSantis
PURPOSE: The efficacy and thrombogenicity of transdermal estradiol in the management of refractory uremic bleeding in adults are examined. SUMMARY: Platelet dysfunction from chronic kidney disease may induce uremic bleeding. This type of bleeding may involve the skin, oral and nasal mucosa, gingivae, respiratory system, and gastrointestinal or urinary tract. While the mainstay of treatment for uremic bleeding primarily involves dialysis and use of prohemostatic agents such as desmopressin and erythropoiesis-stimulating agents, certain patients may experience bleeding refractory to these interventions...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29674409/associations-of-adiponectin-leptin-levels-and-the-change-of-body-composition-in-patients-on-peritoneal-dialysis-a-prospective-cohort-study
#20
Xiao Xu, Xue Tian, Yuan Chen, Zhi-Kai Yang, Zhen Qu, Jie Dong
BACKGROUND: Although the association between adipokines such as adiponectin, leptin, and body composition has been noted, whether they could predict the change of fat mass and lean body mass is unknown. We aimed to examine these associations in patients on peritoneal dialysis (PD) through a prospective cohort study. METHODS: Body composition (by dual-energy x-ray absorptiometry) including fat mass and lean body mass were examined at baseline and then at year 3. Serum leptin and adiponectin levels were measured...
April 19, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
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