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omega-3, DHA, EPA

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https://www.readbyqxmd.com/read/29673104/omega-3-polyunsaturated-fatty-acid-supplementation-reduces-blood-pressure-but-not-renal-vasoconstrictor-response-to-orthostatic-stress-in-healthy-older-adults
#1
Christine M Clark, Kevin D Monahan, Rachel C Drew
Older adults exhibit augmented renal vasoconstriction during orthostatic stress compared to young adults. Consumption of omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil (FO), modulates autonomic nerve activity. However, the effect of omega-3 polyunsaturated fatty acid consumption on the renal vasoconstrictor response to orthostatic stress in young and older adults is unknown. Therefore, 10 young (25 ± 1 years; mean ± SEM) and 10 older (66 ± 2 years) healthy adults ingested 4 g FO daily for 12 weeks, and underwent graded lower body negative pressure (LBNP; -15 and -30 mmHg) pre- and post-FO supplementation...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29672133/meat-eggs-full-fat-dairy-and-nutritional-boogeymen-does-the-way-in-which-animals-are-raised-affect-health-differently-in-humans
#2
Christopher P Haskins, George Henderson, Colin E Champ
BACKGROUND:  Food recommendations to improve cancer prevention are generally based on epidemiologic data and remain inconsistent. These epidemiologic studies, while controversial, have generally produced results that caution against the consumption of high-fat foods, including eggs, red meat, and full-fat dairy, such as butter and cheese. Yet, limited data exist assessing the quality of individual sources of these foods and the effect each has after its consumption. This study set out to assess the impact sources of food within the same groups from animals raised differently on variables associated with health in human studies...
April 19, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29665872/maternal-intake-of-omega-3-and-omega-6-polyunsaturated-fatty-acids-during-mid-pregnancy-is-inversely-associated-with-linear-growth
#3
M Al-Hinai, A Baylin, M M Tellez-Rojo, A Cantoral, A Ettinger, M Solano-González, K E Peterson, W Perng
This study investigates relations of maternal N-3 and N-6 polyunsaturated fatty acids (PUFA) intake during pregnancy with offspring body mass index (BMI), height z-score and metabolic risk (fasting glucose, C-peptide, leptin, lipid profile) during peripuberty (8-14 years) among 236 mother-child pairs in Mexico. We used food frequency questionnaire data to quantify trimester-specific intake of N-3 alpha-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); N-6 linoleic acid and arachidonic acid (AA); and N-6:N-3 (AA:EPA+DHA), which accounts for the fact that the two PUFA families have opposing effects on physiology...
April 18, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29665425/omega-3-polyunsaturated-fatty-acids-promotes-angiogenesis-in-placenta-derived-mesenchymal-stromal-cells
#4
Suja Ann Mathew, Ramesh Bhonde
Enhancement of angiogenesis is solicited in wound repair and regeneration. Mesenchymal stromal cells derived from the placenta (P-MSCs) have an inherent angiogenic potential. Polyunsaturated fatty acids (PUFAs) in turn, specifically the omega-3 (N-3) are essential for growth and development. They are also recommended as dietary supplements during pregnancy. We therefore hypothesized that addition of N-3 PUFAs in P-MSC culture media may enhance their angiogenic potential. Hence we treated P-MSCs with omega-3 (N-3) fatty acids -Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) at different concentrations and tested their angiogenic potential...
April 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29657077/reprint-of-marine-omega-3-fatty-acids-in-the-prevention-of-cardiovascular-disease
#5
Trevor A Mori
Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA)...
April 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29606136/low-omega-3-index-values-and-monounsaturated-fatty-acid-levels-in-early-pregnancy-an-analysis-of-maternal-erythrocytes-fatty-acids
#6
Axelle Hoge, Florence Bernardy, Anne-Françoise Donneau, Nadia Dardenne, Sylvie Degée, Marie Timmermans, Michelle Nisolle, Michèle Guillaume, Vincenzo Castronovo
BACKGROUND: It is unanimously recognized that the maternal nutritional status at the pregnancy onset influence both short-term and long-term health of the mother and offspring. Among several nutrients, LCPUFA, particularly from the omega-3 family, are of utmost importance. This study was carried out to determine fatty acids profile of maternal erythrocyte membranes in early pregnancy and to identify potential determinants impacting on this status. METHODS: A cohort of 122 healthy women with a singleton pregnancy was included...
April 2, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29599053/the-omega-6-omega-3-ratio-a-critical-appraisal-and-possible-successor
#7
REVIEW
William S Harris
The well-known health effects of the long-chain, marine omega-3 (n-3) fatty acids (FAs) has led to a growing interest in the prognostic value that blood levels of these FAs might have vis-à-vis cardiovascular and neurocognitive diseases. The measurement and expression of n-3 FA levels is not straight-forward, however, and a wide variety of means of expression of n-3 FA status have been used in research and clinical medicine. This has led to considerable confusion as to what "optimal" n-3 FA status is...
March 20, 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29597261/dietary-intakes-of-epa-and-dha-omega-3-fatty-acids-among-us-childbearing-age-and-pregnant-women-an-analysis-of-nhanes-2001-2014
#8
Zhiying Zhang, Victor L Fulgoni, Penny M Kris-Etherton, Susan Hazels Mitmesser
BACKGROUND: The 2015–2020 Dietary Guidelines for Americans (DGA) recommend that the general population should consume about 8 ounces (oz.) per week of a variety of seafood, providing approximately 250 mg per day of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and that pregnant and lactating women should consume 8–12 oz. per week of seafood. METHODS: We determined the usual intakes, percentage not meeting recommendations, and trends in EPA and DHA intakes among childbearing-age and pregnant women (15–44 years of age) using the NHANES cycles 2001–2002 through 2013–2014...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29594127/effect-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-myogenesis-and-mitochondrial-biosynthesis-during-murine-skeletal-muscle-cell-differentiation
#9
Tun-Yun Hsueh, Jamie I Baum, Yan Huang
Polyunsaturated fatty acids are important nutrients for human health, especially omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have been found to play positive roles in the prevention of various diseases. However, previous studies have reported that excessive omega-3 fatty acids supplement during pregnancy caused side effects such as slower neural transmission times and postnatal growth restriction. In this study, we investigated the effect of EPA and DHA on mitochondrial function and gene expression in C2C12 myoblasts during skeletal muscle differentiation...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29577958/the-validation-verification-of-an-lc-ms-method-for-the-determination-of-total-docosahexaenoic-acid-concentrations-in-canine-blood-serum
#10
Gerald Patrick Dillon, Jason D Keegan, Geoff Wallace, Alexandros Yiannikouris, Colm Anthony Moran
Docosahexaenoic acid (DHA), is an omega 3 fatty acid (n-3 FA) that has been shown to play a role in canine growth and physiological integrity and improvements in skin and coat condition. However, potential adverse effects of n-3 FA specifically, impaired cellular immunity has been observed in dogs fed diets with elevated levels of n-3 FA. As such, a safe upper limit (SUL) for total n-3 FAs (DHA and EPA) in dogs has been established. Considering this SUL, sensitive methods detecting DHA in blood serum as a biomarker when conducting n-3 FA supplementation trials involving dogs are required...
March 23, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29574773/omega-3-fatty-acids-modulate-the-lipid-profile-membrane-architecture-and-gene-expression-of-leiomyoma-cells
#11
Md Soriful Islam, Clara Castellucci, Rosamaria Fiorini, Stefania Greco, Riccardo Gagliardi, Alessandro Zannotti, Stefano R Giannubilo, Andrea Ciavattini, Natale G Frega, Deborah Pacetti, Pasquapina Ciarmela
Uterine leiomyomas (fibroids or myomas) are the most common benign tumors of premenopausal women and new medical treatments are needed. This study aimed to determine the effects of omega-3 fatty acids on the lipid profile, membrane architecture and gene expression patterns of extracellular matrix components (collagen1A1, fibronectin, versican, or activin A), mechanical signaling (integrin β1, FAK, and AKAP13), sterol regulatory molecules (ABCG1, ABCA1, CAV1, and SREBF2), and mitochondrial enzyme (CYP11A1) in myometrial and leiomyoma cells...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29565163/-depressive-symptoms-and-serum-levels-of-polyunsaturated-fatty-acids-omega-3-and-omega-6-among-college-students-from-northern-mexico
#12
María Rubí Vargas, Efraín Alonso Terrazas-Medina, Ahideé Guadalupe Leyva-López, Sandra Lidia Peralta-Peña, Lea Aurora Cupul-Uicab
INTRODUCTION: Previous studies suggest that low consumption as well as low serum levels of polyunsaturated fatty acids (PUFA) omega-3 and a high omega-6/omega-3 ratio may be implicated in the etiology of depressive disorders, however, epidemiologic evidence is inconclusive. OBJECTIVE: To assess the relationship of serum levels of omega-3 fatty acids (docosahexaenoic [DHA], eicosapentaenoic [EPA], alpha-linolenic fatty acid [ALA]) and the omega-6 (arachidonic acid [AA])/EPA ratio with depressive symptoms among Mexican college students...
November 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29556735/blood-fatty-acid-profiles-new-biomarkers-for-cardiometabolic-disease-risk
#13
REVIEW
Kristina H Jackson, William S Harris
PURPOSE OF REVIEW: Fatty acid (FA) profiles in different blood compartments are reflections of both diet and metabolism, and some FA levels are related to disease risk. RECENT FINDINGS: Perhaps the most studied FA-disease relationship is between long-chain omega-3 polyunsaturated fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and cardiovascular disease (CVD). Despite null results from recent large omega-3 FA supplementation trials, new research continues to support past studies showing that blood levels of EPA + DHA are inversely related to risk for total mortality and fatal CVD events...
March 20, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29555597/oxygenation-of-polyunsaturated-fatty-acids-and-oxidative-stress-within-blood-platelets
#14
REVIEW
Michel Lagarde, Michel Guichardant, Nathalie Bernoud-Hubac, Catherine Calzada, Evelyne Véricel
The oxygenation metabolism of arachidonic acid (ArA) has been early described in blood platelets, in particular with its conversion into the potent labile thromboxane A2 that induces platelet aggregation and vascular smooth muscle cells contraction. In addition, the primary prostaglandins D2 and E2 have been mainly reported as inhibitors of platelet function. The platelet 12-lipoxygenase (12-LOX) product, i.e. the hydroperoxide 12-HpETE, appears to stimulate platelet ArA metabolism at the level of its release from membrane phospholipids through phospholipase A2 (cPLA2 ) and cyclooxygenase (COX-1) activities, the first enzymes in prostanoid production cascade...
March 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29554278/synthesis-of-omega-3-long-chain-polyunsaturated-fatty-acid-rich-triacylglycerols-in-an-endemic-goby-gymnogobius-isaza-from-lake-biwa-japan
#15
Takuto Suito, Kohjiro Nagao, Masataka Hatano, Kenichi Kohashi, Aiko Tanabe, Hiromichi Ozaki, Jun Kawamoto, Tatsuo Kurihara, Tetsuo Mioka, Kazuma Tanaka, Yuji Hara, Masato Umeda
It is commonly observed that freshwater fish contain lower amounts of omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3), than marine fish species. In this study, we performed a detailed comparative analysis of phospholipids (PLs) and triacylglycerols (TAGs) from Gymnogobius isaza, a freshwater goby endemic to Lake Biwa inhabiting the lake bottom, and Gymnogobius urotaenia, a related goby that inhabits the shore of Lake Biwa...
March 15, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29549496/exploring-the-association-between-whole-blood-omega-3-index-dha-epa-dha-aa-and-n-6-dpa-and-depression-and-self-esteem-in-adolescents-of-lower-general-secondary-education
#16
I S M van der Wurff, C von Schacky, T Bergeland, R Leontjevas, M P Zeegers, P A Kirschner, R H M de Groot
PURPOSE: Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE)...
March 16, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29548446/formulation-of-dark-chocolate-as-a-carrier-to-deliver-eicosapentaenoic-and-docosahexaenoic-acids-effects-on-product-quality
#17
Omer Said Toker, Nevzat Konar, Ibrahim Palabiyik, Haniyeh Rasouli Pirouzian, Sirin Oba, Derya Genc Polat, Ender Sinan Poyrazoglu, Osman Sagdic
In this study, dark chocolate enriched with EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) was developed using various forms and origins. Quality characteristics such as physical, thermo-gravimetric, rheological, textural and sensory properties of chocolates were investigated. The highest EPA/DHA stability was determined in samples prepared by free-flowing powder and microencapsulated forms of omega-3 fatty acids (FA). The L∗ and C∗ values varied from 32.16-33.37 and 7.45-8.09, respectively for the all samples...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29546765/awareness-of-omega-3-fatty-acids-and-possible-health-effects-among-young-adults
#18
Kaitlin Roke, Jodi Rattner, Paula Brauer, David M Mutch
PURPOSE: To assess awareness of omega-3 fatty acids (FAs) and their possible health effects among young adults. METHODS: An online survey was deployed to young adults. Questionnaire development involved identification of topic areas by content experts and adaptation of questions from previous consumer surveys. Focus groups and cognitive interviews ensured face validity, feasibility, and clarity of survey questions. Degrees of awareness and self-reported consumption were assessed by descriptive statistics and associations by Cochran's Q tests, Pearson's χ2 tests, Z-tests, and logistic regression...
March 16, 2018: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/29545942/effects-of-the-polyunsaturated-fatty-acids-epa-and-dha-on-hematological-malignancies-a-systematic-review
#19
REVIEW
Milad Moloudizargari, Esmaeil Mortaz, Mohammad Hossein Asghari, Ian M Adcock, Frank A Redegeld, Johan Garssen
Omega-3 polyunsaturated fatty acids (PUFAs) have well established anti-cancer properties. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are among this biologically active family of macromolecules for which various anti-cancer effects have been explained. These PUFAs have a high safety profile and can induce apoptosis and inhibit growth of cancer cells both in vitro and in vivo , following a partially selective manner. They also increase the efficacy of chemotherapeutic agents by increasing the sensitivity of different cell lines to specific anti-neoplastic drugs...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29542390/vitamin-e-and-fish-oil-separately-or-in-combination-on-treatment-of-primary-dysmenorrhea-a-double-blind-randomized-clinical-trial
#20
Narges Sadeghi, Farnoush Paknezhad, Mohamadreza Rashidi Nooshabadi, Maria Kavianpour, Sima Jafari Rad, Hossein Khadem Haghighian
Primary dysmenorrhea is one of the most common complaints of women. The aim of this study was to investigate the adjuvant effect of vitamin E and omega-3 fatty acids, separately or in combination, supplements on pain in the treatment of primary dysmenorrhea. This clinical trial conducted on students of university. Qualified girls completed the VAS before randomization. Arrangement was determined according to the severity of the pain (mild 0-3; moderate 3.1-6; severe 6.1-10). One hundred patients were randomly assigned to four groups receiving omega-3 (n = 25), vitamin E (n = 25), vitamin E- omega-3 (n = 25), or placebo (n = 25)...
March 15, 2018: Gynecological Endocrinology
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