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https://www.readbyqxmd.com/read/29453726/advances-in-probiotic-regulation-of-bone-and-mineral-metabolism
#1
REVIEW
Laura R McCabe, Narayanan Parameswaran
Probiotics have been consumed by humans for thousands of years because they are beneficial for long-term storage of foods and promote the health of their host. Ingested probiotics reside in the gastrointestinal tract where they have many effects including modifying the microbiota composition, intestinal barrier function, and the immune system which result in systemic benefits to the host, including bone health. Probiotics benefit bone growth, density, and structure under conditions of dysbiosis, intestinal permeability, and inflammation (recognized mediators of bone loss and osteoporosis)...
February 16, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29452406/negative-association-between-sclerostin-and-insl3-in-isolated-human-osteocytes-and-in-klinefelter-syndrome-new-hints-for-testis-bone-crosstalk
#2
Andrea Di Nisio, Luca De Toni, Maria Santa Rocca, Marco Ghezzi, Riccardo Selice, Giuseppe Taglialavoro, Alberto Ferlin, Carlo Foresta
Context/Objective: The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insuline-like 3 peptide (INSL3) on the most abundant bone cell population, osteocytes, is unknown. In this study we aimed to investigate the relationship between INSL3 and Sclerostin, an osteocyte-specific protein that negatively regulates bone formation. Design/Setting: Serum sclerostin and INSL3 levels were evaluated in Klinefelter Syndrome (KS) and healthy controls...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29452318/bone-metabolic-markers-in-the-clinical-assessment-of-patients-with-superior-semicircular-canal-dehiscence-treated-with-middle-fossa-craniotomy
#3
Thien Nguyen, Carlito Lagman, John P Sheppard, Courtney Duong, Vera Ong, Jessica Poon, Yasmine Alkhalid, Daniel Azzam, Prasanth Romiyo, Giyarpuram N Prashant, Quinton Gopen, Isaac Yang
BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We aim to investigate the relationships between serum calcium, 25-hydroxyvitamin D, and thyroid stimulating hormone levels, and symptoms in adult patients with SSCD treated through a middle fossa craniotomy. METHODS: Patient demographics and clinical parameters were collected...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451816/effects-of-teriparatide-on-morphology-of-aortic-calcification-in-aged-hyperlipidemic-mice
#4
Jeffrey J Hsu, Jinxiu Lu, Soban Umar, Jason T Lee, Rajan Kulkarni, Yichen Ding, Chih-Chiang Chang, Tzung K Hsiai, Akishige Hokugo, Ioannis Gkouveris, Sotirios Tetradis, Ichiro Nishimura, Linda L Demer, Yin Tintut
Calcific aortic vasculopathy correlates with bone loss in osteoporosis in an age-independent manner. Prior work suggests that teriparatide, the bone anabolic treatment for postmenopausal osteoporosis, may inhibit onset of aortic calcification. Whether teriparatide affects progression of pre-existing aortic calcification, widespread among this patient population, is unknown. Female apolipoprotein E-deficient mice were aged for over one year to induce aortic calcification, treated for 4.5 weeks with daily injections of control vehicle (PBS), teriparatide 40 µg/kg (PTH40) or 400 µg/kg (PTH400), and assayed for aortic calcification by micro-computed tomography (microCT) before and after treatment...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451049/the-increase-in-bone-mineral-density-by-bisphosphonate-with-active-vitamin-d-analogue-is-associated-with-the-serum-calcium-level-within-the-reference-interval-in-postmenopausal-osteoporosis
#5
Mayuko Kinoshita, Muneaki Ishijima, Haruka Kaneko, Lizu Liu, Masashi Nagao, Ryo Sadatsuki, Shinnosuke Hada, Hitoshi Arita, Takako Aoki, Makoto Yamanaka, Hidetoshi Nojiri, Yuko Sakamoto, Akifumi Tokita, Kazuo Kaneko
OBJECTIVES: To examine the factors associated with increase in lumbar spine bone mineral density (LS-BMD) by bisphosphonates (BPs) with active vitamin D analogue (aVD). METHODS: Two independent postmenopausal osteoporotic patients treated by BPs with aVD for 24 months (Study1:n = 93,Study2:n = 99) were retrospectively analyzed. RESULTS: In Study1, LS-BMD of the patients significantly increased for 24m (5.4%,p<0.001). A multiple regression analysis among baseline characteristics revealed that serum calcium (sCa:8...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29447485/should-women-be-screened-for-osteoporosis-at-midlife
#6
T J de Villiers
Osteoporosis and associated fractures are common in women after midlife and will increase as the population ages. Osteoporosis-related fractures cause a significant increase in morbidity and mortality. Osteoporosis decreases the quality of life and productivity of many older women, with an increasing burden on health-care resources. Future risk of fracture can be managed by evidence-based interventions. It is thus appropriate to estimate the future risk of fracture in all women at the age of 50 years or at menopause, whichever occurs first...
February 15, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29447437/j-shaped-association-between-post-operative-levothyroxine-dosage-and-fracture-risk-in-thyroid-cancer-patients-a-retrospective-cohort-study
#7
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Jae Moon Yun, Sun Ok Song, Youngmin Park
Long-term administration of supraphysiologic dosages of levothyroxine can have detrimental effect on the bone. We aimed to investigate fracture incidence among post-thyroidectomy thyroid cancer patients compared with matched comparison group, and explore the association between levothyroxine dosage and fracture risk. From the Korean National Health Insurance database, virtually all thyroid cancer patients who received thyroidectomy in Korea from January 1, 2004 to December 31, 2012 were included. Matched subjects were selected by 1:1 propensity score matching...
February 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29445836/bone-loss-after-romosozumab-denosumab-effects-of-bisphosphonates
#8
Anne M Horne, Borislav Mihov, Ian R Reid
Romosozumab and denosumab are monoclonal antibodies for the treatment of osteoporosis. Both have a rapid offset of effect resulting in loss of bone density (BMD) gained on-treatment and, in some cases, multiple vertebral fractures following treatment cessation. We recently reported disappointing results from transitioning patients from denosumab to intravenous zoledronate at the time the next denosumab injection is due. The present report re-assesses the role of bisphosphonates following the use of denosumab...
February 14, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29445831/using-a-sequential-explanatory-mixed-method-to-evaluate-the-therapeutic-window-of-opportunity-for-initiating-osteoporosis-treatment-following-fragility-fractures
#9
S Roux, I Gaboury, N Gionet-Landry, M-P Garant, M-C Beaulieu, N Carrier, F Cabana, G Boire
Interventions targeting patients with recent fragility fracture and their physician were most successful at initiating osteoporosis treatment during the first 12 months. This window of opportunity had already closed after 1 year. The reasons for declining or accepting the intensive intervention were explored in patients still untreated at 12 months. INTRODUCTION: A fragility fracture (FF) event identifies patients most likely to benefit from osteoporosis treatment. Nonetheless, most FF patients go untreated...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29445830/bone-health-assessment-in-older-people-with-or-without-muscle-health-impairment
#10
M Locquet, C Beaudart, O Bruyère, J A Kanis, L Delandsheere, J-Y Reginster
This study investigated the relationship between muscle and bone status in elderly individuals. Our results suggested links between sarcopenia and osteoporosis; impairment in muscle status (i.e., muscle mass, muscle strength, and physical performance) is associated with deterioration in bone mass and texture subsequently leading to an increased risk of fracture. INTRODUCTION: Accumulating evidence has shown associations between sarcopenia and osteoporosis, but existing studies face inconsistencies in the clinical definition of both conditions...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29443456/pharmacokinetics-and-safety-of-bazedoxifene-in-hepatically-impaired-and-healthy-postmenopausal-women
#11
William McKeand, Susan Baird-Bellaire, James Ermer, Alain Patat
Bazedoxifene, a selective estrogen receptor modulator with proestrogenic effects on bone and lipid metabolism and antiestrogenic effects on the breast and endometrium, is a treatment option for osteoporosis in postmenopausal women. It is extensively metabolized by the liver; therefore, a decrease in liver function was expected to decrease bazedoxifene clearance. This single-dose, open-label, inpatient/outpatient, nonrandomized study assessed the pharmacokinetics of bazedoxifene 20 mg in 18 postmenopausal women with hepatic impairment and 18 matched healthy postmenopausal women...
February 14, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29442051/3-4-7-8-tetrahydroxyflavone-inhibits-rankl-induced-osteoclast-formation-and-bone-resorption
#12
J H Kang, H Jung, M Yim
Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-tetrahydroxyflavone is a flavonoid from Acacia confusa. In the present study, we found that 3',4',7,8-tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7,8-tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29442043/satb1-promotes-osteoclastogenesis-by-recruiting-cbp-to-upregulate-mir-223-expression-in-chronic-kidney-disease-mineral-and-bone-disorder
#13
Jun Li, Guangqun Xing, Lili Zhang, Jinchun Shang, Yuan Li, Chunmei Li, Fen Tian, Xiangdong Yang
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a complex disease which is associated with alterations of bone and mineral metabolism. miR-223 is implicated in both vascular calcification and osteoporosis. In the present study, we investigated the influence of Stab1 gene on miRNA-223 expression in osteoclastogenesis. Differentiation of monocyte/macrophage precursors was assessed by using RAW264.7 cells and peripheral blood mononuclear cells (PBMC). TRAP activity and bone resorption were used to measure osteoclast activity...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441424/selective-serotonin-reuptake-inhibitors-ssris-and-markers-of-bone-turnover-in-men
#14
Lana J Williams, Michael Berk, Jason M Hodge, Mark A Kotowicz, Amanda L Stuart, Vinoomika Chandrasekaran, Jasmine Cleminson, Julie A Pasco
Selective serotonin reuptake inhibitors (SSRIs) have been shown to have a clinically significant impact on bone metabolism. To explore this further, we aimed to determine whether these agents are associated with serum markers of bone turnover utilising a population-based sample of men (n = 1138; 20-96 year) participating in the Geelong Osteoporosis Study. Blood samples were obtained and the bone resorption marker, C-telopeptide (CTx) and formation marker, type 1 procollagen amino-terminal-propeptide (PINP) were measured...
February 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29440880/comparison-of-three-tools-for-predicting-primary-osteoporosis-in-an-elderly-male-population-in-beijing-a-cross-sectional-study
#15
XiaoDong Zhang, JiSheng Lin, Yong Yang, Hao Wu, Yongjin Li, Xiuquan Yang, Qi Fei
Purpose: In this cross-sectional study, three clinical tools, the Osteoporosis Self-Assessment Tool for Asians (OSTA), Fracture Risk Assessment Tool (FRAX) without bone mineral density (BMD), and body mass index (BMI), for predicting primary osteoporosis (OP) were compared and ideal thresholds for omission of screening BMD were proposed in a community-dwelling elderly Han Beijing male population. Patients and methods: A total of 1,349 community-dwelling elderly Han Beijing males aged ≥50 years were enrolled in this study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29440419/epitope-specific-monoclonal-antibodies-to-fsh%C3%AE-increase-bone-mass
#16
Yaoting Ji, Peng Liu, Tony Yuen, Shozeb Haider, Jiahuan He, Raquel Romero, Hao Chen, Madison Bloch, Se-Min Kim, Daria Lizneva, Lubna Munshi, Chunxue Zhou, Ping Lu, Jameel Iqbal, Zhen Cheng, Maria I New, Aaron J Hsueh, Zhuan Bian, Clifford J Rosen, Li Sun, Mone Zaidi
Pituitary hormones have long been thought solely to regulate single targets. Challenging this paradigm, we discovered that both anterior and posterior pituitary hormones, including FSH, had other functions in physiology. We have shown that FSH regulates skeletal integrity, and, more recently, find that FSH inhibition reduces body fat and induces thermogenic adipose tissue. A polyclonal antibody raised against a short, receptor-binding epitope of FSHβ was found not only to rescue bone loss postovariectomy, but also to display marked antiobesity and probeiging actions...
February 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29440390/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
#17
James G Burchfield, Melkam A Kebede, Christopher C Meoli, Jacqueline Stöckli, P Tess Whitworth, Amanda L Wright, Nolan J Hoffman, Annabel Y Minard, Xiuquan Ma, James R Krycer, Marin E Nelson, Shi-Xiong Tan, Belinda Yau, Kristen C Thomas, Natalie K Y Wee, Ee-Cheng Khor, Ronaldo F Enriquez, Bryce Vissel, Trevor J Biden, Paul A Baldock, Kyle L Hoehn, James Cantley, Gregory J Cooney, David E James, Daniel J Fazakerley
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and whether these disorders co-occur is therefore unclear. To address this question, we examined multiple physiological systems in male C57BL/6J mice following prolonged exposure to a high-fat/high-sucrose diet (HFHSD)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29440373/calcium-supplementation-in-osteoporosis-useful-or-harmful
#18
Iacopo Chiodini, Mark J Bolland
Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29439698/a-retrospective-analysis-of-bone-mineral-status-in-patients-requiring-spinal-surgery
#19
Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik, Haider Mussawy
BACKGROUND: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders. METHODS: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29437027/benefits-of-olive-oil-phenolic-compounds-in-disease-prevention
#20
Olga Garcia-Martinez, Concepcion Ruiz, Alvaro Gutierrez-Ibanez, Rebeca Illescas-Montes, Lucia Melguizo-Rodriguez
BACKGROUND AND OBJECTIVE: The preventive effects of olive oil against different diseases have been attributed to its high phenolic compound content. The objective of this study was to examine available scientific evidence on the beneficial effects against chronic diseases of olive oil phenolic compounds. METHOD: This article examines recently published data on olive oil phenolic compounds and their potential benefits in the prevention of cardiovascular disease, cancer, neurodegenerative disease, and osteoporosis...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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