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https://www.readbyqxmd.com/read/29933617/the-effects-of-quassinoid-rich-eurycoma-longifolia-extract-on-bone-turnover-and-histomorphometry-indices-in-the-androgen-deficient-osteoporosis-rat-model
#1
Putri Ayu Jayusman, Isa Naina Mohamed, Ekram Alias, Norazlina Mohamed, Ahmad Nazrun Shuid
Male osteoporosis is associated with higher rates of disability and mortality. Hence the search for suitable intervention and treatment to prevent the degeneration of skeletal health in men is necessary. Eurycoma longifolia (EL), a traditional plant with aphrodisiac potential may be used to treat and prevent male osteoporosis. The skeletal protective effect of quassinoid-rich EL extract, which has a high content of eurycomanone, has not been studied. This study aimed to determine whether EL could prevent skeletal deteriorations in gonadal hormone-deficient male rats...
June 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29932305/long-term-effect-of-exemestane-therapy-on-bone-mineral-density-supported-by-bisphosphonates-results-of-5-year-adjuvant-treatment-in-postmenopausal-women-with-early-stage-breast-cancer
#2
Akira Hirano, Hiroaki Inoue, Kaoru Ogura, Akinori Hattori, Hiroko Yukawa, Shiho Sakaguchi, Aya Matsuoka, Natsuko Tanaka, Asaka Kodera, Mari Kamimura, Yoshihiko Naritaka, Tadao Shimizu
PURPOSE: Unlike anastrozole, the effect of long-term exemestane (EXE) therapy on bone mineral density (BMD) is still unknown. We assessed changes in BMD from baseline to 5 years of EXE treatment. METHODS: Postmenopausal women with endocrine-responsive breast cancer receiving EXE as adjuvant therapy were enrolled in this study. EXE was administered for 5 years. The BMD of the lumbar spine (LS) and femoral neck (FN) was assessed by dual-energy X-ray absorptiometry at baseline and after 6 months and 1, 2, 3, 4, 5 and 6 years...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29932225/abietic-acid-attenuates-rankl-induced-osteoclastogenesis-and-inflammation-associated-osteolysis-by-inhibiting-the-nf-kb-and-mapk-signaling
#3
Dinesh Thummuri, Lalita Guntuku, Veerabhadra Swamy Challa, Ravinder Naik Ramavat, Vegi Ganga Modi Naidu
Osteoporosis is a major debilitating cause of fractures and decreases the quality of life in elderly patients. Bone homeostasis is maintained by bone forming osteoblasts and bone resorpting osteoclasts. Substantial evidences have shown that targeting osteoclasts using natural products is a promising strategy for the treatment of osteoporosis. In the current study, we investigated the osteoprotective effect of Abietic acid (AA) in in vitro and in vivo models of osteolysis. In vitro experiments demonstrated that, AA suppressed receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and F-actin ring formation in a concentration dependent manner...
June 22, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29931664/calcium-and-vitamin-d-in-bone-fracture-healing-and-post-traumatic-bone-turnover
#4
V Fischer, M Haffner-Luntzer, M Amling, A Ignatius
Calcium and vitamin D are essential for maintaining bone health. Therefore, deficiencies in calcium and vitamin D are major risk factors for osteoporosis development. Because sufficient amounts of calcium are also required for fracture-callus mineralisation, compromised bone repair that is frequently observed in osteoporotic patients might be attributed to calcium and vitamin D deficiencies. Consequently, calcium and vitamin D supplementation represents a potential strategy for treating compromised fracture healing in osteoporotic patients...
June 22, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29931461/sclerostin-antibody-reverses-the-severe-sublesional-bone-loss-in-rats-after-chronic-spinal-cord-injury
#5
Wei Zhao, Xiaodong Li, Yuanzhen Peng, Yiwen Qin, Jiangping Pan, Jiliang Li, Aihua Xu, Michael S Ominsky, Christopher Cardozo, Jian Q Feng, Hua Zhu Ke, William A Bauman, Weiping Qin
To date, no efficacious therapy exists that will prevent or treat the severe osteoporosis in individuals with neurologically motor-complete spinal cord injury (SCI). Recent preclinical studies have demonstrated that sclerostin antibody (Scl-Ab) can prevent sublesional bone loss after acute SCI in rats. However, it remains unknown whether sclerostin inhibition reverses substantial bone loss in the vast majority of the SCI population who have been injured for several years. This preclinical study tested the efficacy of Scl-Ab to reverse the bone loss that has occurred in a rodent model after chronic motor-complete SCI...
June 21, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29931216/a-phase-3-randomized-placebo-controlled-trial-to-evaluate-efficacy-and-safety-of-romosozumab-in-men-with-osteoporosis
#6
E Michael Lewiecki, Tomasz Blicharski, Stefan Goemaere, Kurt Lippuner, Paul D Meisner, Paul D Miller, Akimitsu Miyauchi, Judy Maddox, Li Chen, Stephane Horlait
Context: Globally, one in five men over 50 years of age is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and paucity of bone-forming agents for men, there is need for new osteoporosis treatments. Objective: Evaluate the safety and efficacy of romosozumab in men with osteoporosis. Design: Phase 3 randomized placeBo-contRolled double-blind study evaluatIng the efficacy anD safety of romosozumab in treatinG mEn with osteoporosis (BRIDGE; NCT02186171) for 12 months...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29930358/is-osteoporosis-a-risk-factor-for-implant-survival-or-failure
#7
Alessandro Grisa, Analia Veitz-Keenan
Data sourcesAn electronic search was performed in PubMed, Web of Science and the Cochrane Library and SciELO databases up to September 2016. References of included studies were also searched. English language restriction was applied.Study selectionClinical monitoring studies with at least six months of follow-up, including retrospective studies, prospective studies, and controlled and randomised clinical trials. Clinical case studies were excluded from the sample and only studies with a minimum of five patients were considered...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29929041/bone-and-plasma-citrate-is-reduced-in-osteoporosis
#8
Hongdong Chen, Yeyang Wang, Huaiqian Dai, Xinggui Tian, Zhong-Kai Cui, Zhenguo Chen, Le Hu, Qiancheng Song, Anling Liu, Zhiyong Zhang, Guozhi Xiao, Jian Yang, Yu Jiang, Xiaochun Bai
High concentration of citrate exists in bone of humans and all osteo-vertebrates, and citrate incorporation imparts important biomechanical and other functional properties to bone. However, which cells are responsible for citrate production in bone remains unclear and whether the citrate component changes with bone loss during osteoporosis is also not known. Here, we show that the citrate content is markedly reduced in the bone of mice or rats with age-related, ovariectomy-induced or retinoic acid-induced bone loss...
June 18, 2018: Bone
https://www.readbyqxmd.com/read/29928929/site-specific-differences-in-osteoblast-phenotype-mechanical-loading-response-and-estrogen-receptor-related-gene-expression
#9
Borzo Gharibi, Mandeep S Ghuman, Giuseppe Cama, Simon C F Rawlinson, Agamemnon E Grigoriadis, Francis J Hughes
The osteoporosis-resistant nature of skull bones implies inherent differences exist between their cellular responses and those of other osteoporosis-susceptible skeletal sites. Phenotypic differences in calvarial and femoral osteoblastic responses to induction of osteogenesis, mechanical loading, estrogen, growth factor and cytokine stimulation were investigated. Primary rat calvarial and femoral adult male osteoblasts were cultured and osteoblastic mineralisation and maturation determined using Alizarin Red staining and expression of osteogenic marker genes assessed...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29926979/lactobacillus-reuteri-reduces-bone-loss-in-older-women-with-low-bone-mineral-density-a-randomized-placebo-controlled-double-blind-clinical-trial
#10
Anna G Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon
The importance of the gut microbiome for bone metabolism in mice has recently been demonstrated, but no studies are available in humans. Lactobacillus reuteri ATCCPTA 6475 (L. reuteri 6475) has been reported to increase bone mineral density (BMD) in mice but its effect on the human skeleton is unknown. The objective of this trial was to investigate if L. reuteri 6475 affects bone loss in older women with low BMD. In this double-blind, placebo-controlled study, women from the population who were 75 to 80 years old and had low BMD were randomized to orally receive 1010 colony-forming units of L...
June 21, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29926975/is-there-a-place-for-bone-turnover-markers-in-the-management-of-osteoporosis
#11
B L Langdahl
No abstract text is available yet for this article.
June 21, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29926970/parathyroid-hormone-for-bone-regeneration
#12
REVIEW
Samantha J Wojda, Seth W Donahue
Delayed healing and/or non-union occur in approximately 5-10% of the fractures that occur annually in the United States. Segmental bone loss increases the probability of non-union. Though grafting can be an effective treatment for segmental bone loss, autografting is limited for large defects since a limited amount of bone is available for harvest. Parathyroid hormone (PTH) is a key regulator of calcium homeostasis in the body and plays an important role in bone metabolism. Presently PTH is FDA approved for use as an anabolic treatment for osteoporosis...
June 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29926935/bacteria-bones-and-stones-managing-complications-of-short-bowel-syndrome
#13
REVIEW
Erika Johnson, Long Vu, Laura E Matarese
Short bowel syndrome (SBS) occurs in patients who have had extensive resection. The primary physiologic consequence is malabsorption, resulting in fluid and electrolyte abnormalities and malnutrition. Nutrient digestion, absorption, and assimilation may also be diminished by disturbances in the production of bile acids and digestive enzymes. Small bowel dilation, dysmotility, loss of ileocecal valve, and anatomical changes combined with acid suppression and antimotility drugs increase the risk of small intestinal bacterial overgrowth, further contributing to malabsorption...
June 21, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29924424/identification-of-an-epigenetic-signature-of-osteoporosis-in-blood-dna-of-post-menopausal-women
#14
David Cheishvili, Surabhi Parashar, Niaz Mahmood, Ani Arakelian, Richard Kremer, David Goltzman, Moshe Szyf, Shafaat A Rabbani
Osteoporosis is one of the most common age-related progressive bone diseases in elderly people. Approximately one in three women and one in five men are predisposed to developing OP. In postmenopausal women a reduction in bone mineral density (BMD) leads to an increased risk of fractures. In the current study we delineated the DNA methylation signatures in whole blood samples of postmenopausal osteoporotic women. We obtained whole blood DNA from 22 normal women and 22 postmenopausal osteoporotic women (51-89 years) from the Canadian Multicenter Osteoporosis Study (CaMos) cohort...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29923225/bone-turnover-markers-are-not-associated-with-hip-fracture-risk-a-case-control-study-in-the-women-s-health-initiative
#15
Carolyn J Crandall, Sowmya Vasan, Andrea LaCroix, Meryl S LeBoff, Jane A Cauley, John A Robbins, Rebecca D Jackson, Douglas C Bauer
Current guidelines recommend that serum C-terminal telopeptide of type I collagen (CTX) and serum procollagen type 1 aminoterminal propeptide (PINP), measured by standardized assays, be used as reference markers in observational and interventional studies. However, there are limited data to determine whether serum CTX and PINP are associated with hip fracture risk among postmenopausal women. We determined the associations of serum CTX and serum PINP with hip fracture risk among postmenopausal women aged 50 to 79 years at baseline...
June 19, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29922744/anti-nerve-growth-factor-therapy-attenuates-cutaneous-hypersensitivity-and-musculoskeletal-discomfort-in-mice-with-osteoporosis
#16
Miyako Suzuki, Magali Millecamps, Seiji Ohtori, Chisato Mori, Laura S Stone
Introduction: The prevalence of osteoporosis is increasing with the aging population and is associated with increased risk of fracture and chronic pain. Osteoporosis is currently treated with bisphosphonate therapy to attenuate bone loss. We previously reported that improvement in bone mineral density is not sufficient to reduce osteoporosis-related pain in an ovariectomy (OVX)-induced mouse model of osteoporosis, highlighting the need for new treatments. Targeting of nerve growth factor (NGF) with sequestering antibodies is a promising new direction for the treatment of musculoskeletal pain including back pain and arthritis...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922706/soy-protein-improves-tibial-whole-bone-and-tissue-level-biomechanical-properties-in-ovariectomized-and-ovary-intact-low-fit-female-rats
#17
Pamela S Hinton, Laura C Ortinau, Rebecca K Dirkes, Emily L Shaw, Matthew W Richard, Terese Z Zidon, Steven L Britton, Lauren G Koch, Victoria J Vieira-Potter
Background: Osteoporosis and related fractures, decreased physical activity, and metabolic dysfunction are serious health concerns for postmenopausal women. Soy protein might counter the negative effects of menopause on bone and metabolic health due to the additive or synergistic effects of its bioactive components. Objective: To evaluate the effects of ovariectomy (OVX) and a soy-protein diet (SOY) on bone outcomes in female, low-capacity running (LCR) rats selectively bred for low aerobic fitness as a model of menopause...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29922447/the-influence-of-age-and-osteoporosis-on-bone-marrow-stem-cells-from-rats
#18
A Sanghani-Kerai, L Osagie-Clouard, G Blunn, M Coathup
Objectives: This study aimed to assess the effect of age and osteoporosis on the proliferative and differentiating capacity of bone-marrow-derived mesenchymal stem cells (MSCs) in female rats. We also discuss the role of these factors on expression and migration of cells along the C-X-C chemokine receptor type 4 (CXCR-4) / stromal derived factor 1 (SDF-1) axis. Methods: Mesenchymal stem cells were harvested from the femora of young, adult, and osteopenic Wistar rats...
April 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922235/association-of-vitamin-d-receptor-gene-variation-with-osteoporosis-risk-in-belarusian-and-lithuanian-postmenopausal-women
#19
Pavel M Marozik, Marija Tamulaitiene, Ema Rudenka, Vidmantas Alekna, Irma Mosse, Alena Rudenka, Volha Samokhovec, Katsiaryna Kobets
Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. VDR dysfunction might substantially contribute to development of postmenopausal osteoporosis (PMO). Numerous studies have revealed the effects of several VDR gene variants on osteoporosis risk, although significant variation in different ethnicities have been suggested. The main purpose of this work was to assess the frequency of distribution of VDR genetic variants with established effect and evaluate their haplotype association with the risk of PMO in a cohort of Belarusian and Lithuanian women...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29921374/regulation-of-vitamin-d-receptor-and-genistein-on-bone-metabolism-in-mouse-osteoblasts-and-the-molecular-mechanism-of-osteoporosis
#20
C F Ye, Y M Pan, H Zhou
The aim of this work was to study the mechanisms of vitamin D receptor (VDR) and Genistein (Gen) on the regulation of bone metabolism of phytoestrogens from cellular and epidemiological perspectives. MC3T3-E1 cells were treated with different concentrations of Gen, and the cell-proliferation rate was detected by an MTT colorimetric assay. The effect of the VDR receptor blocker ZK159222 on the Gen effect was then observed; after adding Gen to MC3T3-E1 cells, we detected the expression of VDR protein via Western blotting...
May 2018: Journal of Biological Regulators and Homeostatic Agents
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