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https://www.readbyqxmd.com/read/29792757/field-trials-of-ontario-rabies-vaccine-bait-in-the-northeastern-usa-2012-14
#1
Amy T Gilbert, Shylo R Johnson, Kathleen M Nelson, Richard B Chipman, Kurt C VerCauteren, Timothy P Algeo, Charles E Rupprecht, Dennis Slate
In the US, rabies virus (RV) has been enzootic in raccoons ( Procyon lotor) since the late 1940s. Oral rabies vaccination (ORV) was implemented in the 1990s to halt the spread of raccoon RV and continues to be used as a wildlife management tool. Our objective was to evaluate a recombinant human adenovirus-rabies virus glycoprotein vaccine in northern New York, Vermont, and New Hampshire over a 3-yr period, using changes in RV neutralizing antibody (RVNA) seroprevalence in raccoon populations as an immunologic index of ORV impact...
May 24, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29789565/the-wide-utility-of-rabbits-as-models-of-human-diseases
#2
REVIEW
Pedro J Esteves, Joana Abrantes, Hanna-Mari Baldauf, Lbachir BenMohamed, Yuxing Chen, Neil Christensen, Javier González-Gallego, Lorenzo Giacani, Jiafen Hu, Gilla Kaplan, Oliver T Keppler, Katherine L Knight, Xiang-Peng Kong, Dennis K Lanning, Jacques Le Pendu, Ana Lemos de Matos, Jia Liu, Shuying Liu, Ana M Lopes, Shan Lu, Sheila Lukehart, Yukari C Manabe, Fabiana Neves, Grant McFadden, Ruimin Pan, Xuwen Peng, Patricia de Sousa-Pereira, Ana Pinheiro, Masmudur Rahman, Natalie Ruvoën-Clouet, Selvakumar Subbian, Maria Jesús Tuñón, Wessel van der Loo, Michael Vaine, Laura E Via, Shixia Wang, Rose Mage
Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases...
May 22, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29787783/segmentation-of-the-rabies-virus-genome
#3
Yuya Hidaka, Chang-Kweng Lim, Mutsuyo Takayama-Ito, Chun-Ho Park, Kazunori Kimitsuki, Nozomi Shiwa, Ken-Ichi Inoue, Takuya Itou
We established a system for the recovery of a segmented recombinant rabies virus, the virus genome RNA of which was divided into two parts: segment 1 encoding the nucleoprotein, phosphoprotein, matrix protein, and glycoprotein genes, and segment 2 encoding the large RNA-dependent RNA polymerase gene. The morphology of the segmented recombinant rabies virus was bullet-like in shape with a length of approximately 130 nm, which is shorter than the 200-nm long non-segmented recombinant rabies virus. The segmented recombinant rabies virus was maintained for at least 18 passages...
May 19, 2018: Virus Research
https://www.readbyqxmd.com/read/29785730/evidence-of-australian-bat-lyssavirus-infection-in-diverse-australian-bat-taxa
#4
Hume Ernest Field
Historically, Australia was considered free of rabies and rabieslike viruses. Thus, the identification of Australian bat lyssavirus (ABLV) in 1996 in a debilitated bat found by a member of the public precipitated both public health consternation and a revision of lyssavirus taxonomy. Subsequent observational studies sought to elaborate the occurrence and frequency of ABLV infection in Australian bats. This paper describes the taxonomic diversity of bat species showing evidence of ABLV infection to better inform public health considerations...
May 21, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29781673/rabies-of-canid-biotype-in-wild-dog-lycaon-pictus-and-spotted-hyaena-crocuta-crocuta-in-madikwe-game-reserve-south-africa-in-2014-2015-diagnosis-possible-origins-and-implications-for-control
#5
Claude T Sabeta, Drienie Janse van Rensburg, Baby Phahladira, Debra Mohale, Robert F Harrison-White, Carlien Esterhuyzen, June H Williams
Both domestic and wild carnivore species are commonly diagnosed with rabies virus (RABV) infection in South Africa. Although the majority of confirmed rabies cases in wild carnivore species are reported from the yellow mongoose (Cynictis penicillata), the rest are from other wild carnivores including the highly endangered wild dog (Lycaon pictus). Lyssavirus infection was confirmed in two wild dogs and a spotted hyaena (Crocuta crocuta) in the Madikwe Game Reserve, North West province in South Africa, in 2014 and 2015, using a direct fluorescent antibody test and immunohistochemistry...
April 26, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29764319/rabies-in-alaska-from-the-past-to-an-uncertain-future
#6
Karsten Hueffer, Molly Murphy
Rabies is a serious zoonotic disease with significant public health consequences in the circumpolar North. Recent studies have advanced our understanding of the disease ecology in Alaska. In this paper, we review historical records of rabies in Alaska ranging from the late nineteenth century to the present, analyse the public health impact in the state and review studies on disease ecology before assessing challenges and anticipated altered disease dynamics in the face of a rapidly changing North. Rabies is a disease that has been present in Alaska continuously for over 100 years...
December 2018: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29745870/isolation-antigenicity-and-immunogenicity-of-lleida-bat-lyssavirus
#7
Ashley C Banyard, David Selden, Guanghui Wu, Leigh Thorne, Daisy Jennings, Denise Marston, Stefan Finke, Conrad M Freuling, Thomas Müller, Juan E Echevarría, Anthony R Fooks
The lyssaviruses are an important group of viruses that cause a fatal encephalitis termed rabies. The prototypic lyssavirus, rabies virus, is predicted to cause more than 60 000 human fatalities annually. The burden of disease for the other lyssaviruses is undefined. The original reports for the recently described highly divergent Lleida bat lyssavirus were based on the detection of virus sequence alone. The successful isolation of live Lleida bat lyssavirus from the carcass of the original bat and in vitro characterization of this novel lyssavirus are described here...
May 10, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29740679/analysis-of-rabies-diagnosis-in-dogs-and-cats-in-the-state-of-s%C3%A3-o-paulo-brazil
#8
Juliana Galera Castilho, Samira Maria Achkar, Rafael de Novaes Oliveira, Enio Mori, Pedro Carnieli, Carla Isabel Macedo
The genetic lineage of rabies virus (RABV) associated with dogs has not been found in the state of São Paulo since 1998, and all cases of rabies in domestic animals reported since then have involved the RABV lineage that circulates in bats. As there has been a change in the rabies transmission cycle in cats and dogs, we decided to analyze the tests used to diagnose rabies in these animals in the 15-year period from 2002 to 2016 in the state of São Paulo. During this period, 85,508 central nervous system (CNS) samples from dogs and cats were submitted to the Rabies Diagnosis Section at the Pasteur Institute of São Paulo for testing...
May 8, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29727680/efficient-generation-of-ca3-neurons-from-human-pluripotent-stem-cells-enables-modeling-of-hippocampal-connectivity-in-vitro
#9
Anindita Sarkar, Arianna Mei, Apua C M Paquola, Shani Stern, Cedric Bardy, Jason R Klug, Stacy Kim, Neda Neshat, Hyung Joon Kim, Manching Ku, Maxim N Shokhirev, David H Adamowicz, Maria C Marchetto, Roberto Jappelli, Jennifer A Erwin, Krishnan Padmanabhan, Matthew Shtrahman, Xin Jin, Fred H Gage
Despite widespread interest in using human induced pluripotent stem cells (hiPSCs) in neurological disease modeling, a suitable model system to study human neuronal connectivity is lacking. Here, we report a comprehensive and efficient differentiation paradigm for hiPSCs that generate multiple CA3 pyramidal neuron subtypes as detected by single-cell RNA sequencing (RNA-seq). This differentiation paradigm exhibits characteristics of neuronal network maturation, and rabies virus tracing revealed synaptic connections between stem cell-derived dentate gyrus (DG) and CA3 neurons in vitro recapitulating the neuronal connectivity within the hippocampus...
May 3, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29727444/a-research-agenda-to-reinforce-rabies-control-a-qualitative-and-quantitative-prioritization
#10
Anne M G Neevel, Tessa Hemrika, Eric Claassen, Linda H M van de Burgwal
BACKGROUND: Despite the existence of safe and effective vaccines, rabies disease still causes an estimated 59,000 human deaths a year in the endemic areas in Asia and Africa. These numbers reflect severe drawbacks regarding the implementation of PrEP and PEP in endemic settings, such as lack of political will and low priority given to rabies. Since these contextual factors have proven to be persistent, there is an urgency to improve current strategies or develop novel approaches in order to control rabies disease in the future...
May 4, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29726121/meeting-the-urgent-need-for-rabies-education-in-haiti
#11
M O V Osinubi, N Fenelon, J L Dyer, R Franka, M Etheart, A Ali, M Birhane, N Phaimyr Jn Charles, A Destine, N Saleme, C Newman, K Crowdis, C Lutfy, C E Rupprecht, R M Wallace, V R Johnson
The highest rate of human rabies deaths reported in the Americas is in Haiti, and most of these deaths result from rabies virus infections that occur after individuals are bitten by infected dogs and do not receive rabies post-exposure prophylaxis. One barrier to rabies prevention in Haiti is a lack of knowledge about this disease among healthcare professionals and community members. During the past 4 years, The US Centers for Disease Control and Prevention has collaborated with public health officials and partners to develop, test and refine educational materials aimed at filling this need for rabies education...
May 3, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29723260/younger-vampire-bats-desmodus-rotundus-are-more-likely-than-adults-to-explore-novel-objects
#12
Gerald G Carter, Sofia Forss, Rachel A Page, John M Ratcliffe
The effects of age on neophobia and exploration are best described in birds and primates, and broader comparisons require reports from other taxa. Here we present data showing age-dependent exploration in a long-lived social species, the common vampire bat (Desmodus rotundus). A previous study found that vampire bats regurgitated food to partners trapped in a cage. Interestingly, while only a few adult bats visited the trapped bat, in every trial all or most of the eight young males in the colony would visit the trapped bat without feeding it...
2018: PloS One
https://www.readbyqxmd.com/read/29717641/eastern-equine-encephalitis-in-puppies-in-michigan-and-new-york-states
#13
Caroline Andrews, Jodie Gerdin, Jon Patterson, Elizabeth L Buckles, Scott D Fitzgerald
Eastern equine encephalitis virus (EEEV) is classified as a select agent and is capable of causing mortality in humans and a number of veterinary species. Herein, we describe 3 cases of EEE in puppies in Michigan and New York. Two puppies were euthanized following an acute history of seizures and obtundation. A littermate of one of these puppies died 2 wk earlier following a history of anorexia and fever. All 3 puppies lacked significant gross anatomic lesions at autopsy and tested negative for rabies virus...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29715287/multisectoral-prioritization-of-zoonotic-diseases-in-uganda-2017-a-one-health-perspective
#14
Musa Sekamatte, Vikram Krishnasamy, Lilian Bulage, Christine Kihembo, Noelina Nantima, Fred Monje, Deo Ndumu, Juliet Sentumbwe, Betty Mbolanyi, Robert Aruho, Winyi Kaboyo, David Mutonga, Colin Basler, Sarah Paige, Casey Barton Behravesh
BACKGROUND: Zoonotic diseases continue to be a public health burden globally. Uganda is especially vulnerable due to its location, biodiversity, and population. Given these concerns, the Ugandan government in collaboration with the Global Health Security Agenda conducted a One Health Zoonotic Disease Prioritization Workshop to identify zoonotic diseases of greatest national concern to the Ugandan government. MATERIALS AND METHODS: The One Health Zoonotic Disease Prioritization tool, a semi-quantitative tool developed by the U...
2018: PloS One
https://www.readbyqxmd.com/read/29709902/development-of-a-quantitative-real-time-rt-pcr-assay-for-detecting-taiwan-ferret-badger-rabies-virus-in-ear-tissue-of-ferret-badgers-and-mice
#15
Ai-Ping Hsu, Chun-Hsien Tseng, Yi-Ta Lu, Yu-Hua Shih, Chung-Hsi Chou, Re-Shang Chen, Kuo-Jung Tsai, Wen-Jane Tu, Florence Cliquet, Hsiang-Jung Tsai
In 2013, the first case of Taiwan ferret badger rabies virus (RABV-TWFB) infection was reported in Formosan ferret badgers, and two genetic groups of the virus were distinguished through phylogenetic analysis. To detect RABV-TWFB using a sensitive nucleic acid-based method, a quantitative real-time reverse transcription polymerase chain reaction targeting the conserved region of both genetic groups of RABV-TWFB was developed. This method had a limit of detection (LOD) of 40 RNA copies/reaction and detected viral RNA in brain and ear tissue specimens of infected and dead Formosan ferret badgers and mice with 100% sensitivity and specificity...
April 30, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29699044/-differences-on-geographic-distribution-of-rabies-virus-lineages-in-china
#16
Q Wang, M L Li, Y Chen, B Wang, X Y Tao, W Y Zhu
Objective: To study the lineages of rabies virus and the epidemic characteristics in different provincial populations of China, to provide information for the development of control and prevention measures in each respective provinces. Methods: Full length N and G genes and full-genome of epidemic strains of rabies virus collected in China were downloaded from GenBank and combined with newly sequenced strains by our lab. Each strain was classified under six lineages of China rabies by constructing phylogenetic trees based on the N or G sequences...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29698385/notes-from-the-field-identification-of-tourists-from-switzerland-exposed-to-rabies-virus-while-visiting-the-united-states-january-2018
#17
Emily G Pieracci, Danielle Stanek, Daniel Koch, Katrin S Kohl, Jesse D Blanton, Terri Harder, Marian O'Brien, Hugo Leon, Pam Colarusso, Brittany Baker, Clive Brown, Kendra E Stauffer, Brett W Petersen, Ryan M Wallace
No abstract text is available yet for this article.
April 27, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29695700/-rabies-virus-glycoprotein-with-a-consensus-amino-acid-sequence-and-a-lysosome-targeting-signal-causes-effective-production-of-antibodies-in-dna-immunized-mice
#18
E S Starodubova, Y V Kuzmenko, E O Pankova, A A Latanova, O V Preobrazhenskaya, V L Karpov
Safe and effective anti-rabies vaccines are intensely sought worldwide. DNA vaccines have already shown their efficacy and safety and have occupied a special place in the field. Two prototype anti-rabies DNA vaccines were compared for the potential to induce virus-specific antibody production. One vector contained a codon-optimized gene with a territory-adapted consensus sequence of the rabies virus glycoprotein. The other one expressed the same glycoprotein in fusion with a c-CD63 lysosome targeting motif at the C terminus...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29688735/evaluation-and-phylogenetic-analysis-of-regular-rabies-virus-vaccine-strains
#19
Mehdi Ajorloo, Habibollah Mirzaei, Yasaman Sadeghi, Nastaran Tarban, Saber Soltani, Fatemeh Sadat Mohammadi, Pardis Davarinejad, Maedeh Amiri Roudy, Hamid Reza Jahantigh, Kosar Abouhamzeh, Mina Mohammadhosayni, Hadi Razavi Nikoo, Ashkan Alamdary, Mehdi Norouzi
BACKGROUND: This study aimed to evaluate Rabies virus vaccine strains. The obtained results may be helpful for vaccine producers and researchers to compare the strains with wild type and other vaccine strains and select the correct strain to challenge their products. METHODS: Fourteen rabies virus vaccine strains were compared with each other. The full genomes of the selected strains were taken from the GenBank and the N, P and G genes were labeled. The major and minor antigenic sites of these sequences were identified and contrasted with each other...
March 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29675803/drosophila-s2-cell-culture-in-a-wave-bioreactor-potential-for-scaling-up-the-production-of-the-recombinant-rabies-virus-glycoprotein
#20
Monize Caiado Decarli, Diogo Peres Dos Santos, Renato Mancini Astray, Daniella Cristina Ventini-Monteiro, Soraia Attie Calil Jorge, Daniela Matilde Correia, Juliana de Sá da Silva, Mayra Pereira Rocca, Hélio Langoni, Benedito Donizete Menozzi, Carlos Augusto Pereira, Claudio Alberto Torres Suazo
The transmembrane rabies virus glycoprotein (RVGP) is the main antigen of vaccine formulations used around the world to prevent rabies, the most lethal preventable infectious disease known. The objective of this work was to evaluate the potential of a bioreactor using wave-induced agitation in the initial steps of scaling up the rRVGP production process by a Drosophila melanogaster S2 cell line to produce rRVGP in sufficient quantities for immunization and characterization studies. Taking advantage of some remarkable features recognized in Drosophila S2 cells for scaling the culture process, a robust recombinant lineage (S2MtRVGPH-His) engineered by our group for the expression of rRVGP using a copper-inducible promoter was used in the bioreactor cultures...
April 19, 2018: Applied Microbiology and Biotechnology
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