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https://www.readbyqxmd.com/read/28442693/ab-interno-schlemm-s-canal-surgery
#1
Brian A Francis, Handan Akil, Benjamin B Bert
In primary open-angle glaucoma, the site of greatest resistance to aqueous outflow is thought to be the trabecular meshwork (TM) and inner wall of Schlemm's canal. Augmentation of the conventional (trabecular) outflow pathway can facilitate physiologic outflow and subsequently lower intraocular pressure. The most recent approach to enhancing the conventional outflow pathway is via an internal approach to the TM and Schlemm's canal. Ab interno Schlemm's canal surgery includes 4 novel surgical approaches: (1) removal of the TM and inner wall of Schlemm's canal by an internal approach (ab interno trabeculectomy), (2) implantation of a microstent to bypass the TM, (3) disruption of the TM and inner wall of Schlemm's canal via an internal approach (ab interno trabeculotomy), and (4) dilation of Schlemm's canal via an internal approach (ab interno canaloplasty)...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28431164/low-activity-microstates-during-sleep
#2
Hiroyuki Miyawaki, Yazan N Billeh, Kamran Diba
Study Objectives: To better understand the distinct activity patterns of the brain during sleep, we observed and investigated periods of diminished oscillatory and population spiking activity lasting for seconds during non-REM sleep, which we call "LOW" activity sleep. Methods: We analyzed spiking and local field potential (LFP) activity of hippocampal CA1 region alongside neocortical electroencephalogram (EEG) and electromyogram (EMG) in 19 sessions from four male Long-Evans rats (262-363g) during natural wake/sleep across the 24-hr cycle, as well as data from other brain regions obtained from http://crcns...
April 18, 2017: Sleep
https://www.readbyqxmd.com/read/28415287/effect-of-interstitial-fluid-on-the-fraction-of-flow-microstates-that-precede-clogging-in-granular-hoppers
#3
Juha Koivisto, Douglas J Durian
We report on the nature of flow events for the gravity-driven discharge of glass beads through a hole that is small enough that the hopper is susceptible to clogging. In particular, we measure the average and standard deviation of the distribution of discharged masses as a function of both hole and grain sizes. We do so in air, which is usual, but also with the system entirely submerged under water. This damps the grain dynamics and could be expected to dramatically affect the distribution of the flow events, which are described in prior work as avalanche-like...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28402876/mechanistic-models-fit-to-variable-temperature-calorimetric-data-provide-insights-into-cooperativity
#4
Elihu C Ihms, Ian R Kleckner, Paul Gollnick, Mark P Foster
Allostery pervades macromolecular function and drives cooperative binding of ligands to macromolecules. To decipher the mechanisms of cooperative ligand binding it is necessary to define at a microscopic level the structural and thermodynamic consequences of binding of each ligand to its allosterically coupled site(s). However, dynamic sampling of alternative conformations (microstates) in allosteric molecules complicates interpretation of both structural and thermodynamic data. Isothermal titration calorimetry has the potential to directly quantify the thermodynamics of allosteric interactions, but usually falls short of enabling mechanistic insight...
April 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28348884/xen-glaucoma-implant-with-mitomycin-c-1-year-follow-up-result-and-complications
#5
Ahmed Galal, Alper Bilgic, Rasha Eltanamly, Amr Osman
Purpose. To evaluate gel microstent (XEN, Aquesys, Inc) for treatment of primary open angle glaucoma (POAG). Methods. In this prospective interventional study, 13 eyes with POAG underwent XEN implantation with subconjunctival mitomycin-C. Of those eyes, 3 were pseudophakic and 10 underwent simultaneous phacoemulsification and XEN. Patients had uncontrolled IOP, had intolerance to therapy, or had maximal therapy but undergoing cataract extraction. Follow-up visits included IOP, number of medications, vision, and complications and lasted for 1 year...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28269507/mining-cross-frequency-coupling-microstates-cfc%C3%AE-states-from-eeg-recordings-during-resting-state-and-mental-arithmetic-tasks
#6
Stavros I Dimitriadis, Yu Sun, Nitish Thakor, Anastasios Bezerianos
The functional brain connectivity has been studied by analyzing synchronization between dynamic oscillations of identical frequency or between different frequencies of distinct brain areas. It has been hypothesized that cross-frequency coupling (CFC) between different frequency bands is the carrier mechanism for the coordination of global and local neural processes and hence supports the distributed information processing in the brain. In the present study, we attempt to study the dynamic evolution of CFC at resting-state and during a mental task...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269506/mining-cross-frequency-coupling-microstates-from-resting-state-meg-an-application-to-mild-traumatic-brain-injury
#7
Marios Antonakakis, Stavros I Dimitriadis, Michalis Zervakis, Andrew C Papanicolaou, George Zouridakis
Recent studies have investigated the possible role of dynamic functional connectivity and the role of cross-frequency coupling (CFC) to provide the substrate for reliable biomarkers of brain disorders. In this study, we analyzed time-varying CFC profiles from resting state Magnetoencephal-ographic recordings of 30 mild Traumatic Brain Injury (mTBI) patients and 50 normal controls. Interactions among sensors at specific pairs of frequency bands were computed via estimation of phase-to-amplitude couplings. We then computed time-varying functional connectivity graphs that were described in terms of segregation (local efficiency, LE) and integration (global efficiency, GE) and mapped those graphs to time series of GE/LE estimates...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227759/mining-cross-frequency-coupling-microstates-cfc%C3%AE-states-from-eeg-recordings-during-resting-state-and-mental-arithmetic-tasks
#8
Stavros I Dimitriadis, Yu Sun, Nitish Thakor, Anastasios Bezerianos, Stavros I Dimitriadis, Yu Sun, Nitish Thakor, Anastasios Bezerianos, Stavros I Dimitriadis, Yu Sun, Nitish Thakor, Anastasios Bezerianos
The functional brain connectivity has been studied by analyzing synchronization between dynamic oscillations of identical frequency or between different frequencies of distinct brain areas. It has been hypothesized that cross-frequency coupling (CFC) between different frequency bands is the carrier mechanism for the coordination of global and local neural processes and hence supports the distributed information processing in the brain. In the present study, we attempt to study the dynamic evolution of CFC at resting-state and during a mental task...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227758/mining-cross-frequency-coupling-microstates-from-resting-state-meg-an-application-to-mild-traumatic-brain-injury
#9
Marios Antonakakis, Stavros I Dimitriadis, Michalis Zervakis, Andrew C Papanicolaou, George Zouridakis, Marios Antonakakis, Stavros I Dimitriadis, Michalis Zervakis, Andrew C Papanicolaou, George Zouridakis, Michalis Zervakis, Marios Antonakakis, George Zouridakis, Andrew C Papanicolaou, Stavros I Dimitriadis
Recent studies have investigated the possible role of dynamic functional connectivity and the role of cross-frequency coupling (CFC) to provide the substrate for reliable biomarkers of brain disorders. In this study, we analyzed time-varying CFC profiles from resting state Magnetoencephal-ographic recordings of 30 mild Traumatic Brain Injury (mTBI) patients and 50 normal controls. Interactions among sensors at specific pairs of frequency bands were computed via estimation of phase-to-amplitude couplings. We then computed time-varying functional connectivity graphs that were described in terms of segregation (local efficiency, LE) and integration (global efficiency, GE) and mapped those graphs to time series of GE/LE estimates...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28116239/characterization-of-functional-brain-activity-and-connectivity-using-eeg-and-fmri-in-patients-with-sickle-cell-disease
#10
Michelle Case, Huishi Zhang, John Mundahl, Yvonne Datta, Stephen Nelson, Kalpna Gupta, Bin He
Sickle cell disease (SCD) is a red blood cell disorder that causes many complications including life-long pain. Treatment of pain remains challenging due to a poor understanding of the mechanisms and limitations to characterize and quantify pain. In the present study, we examined simultaneously recording functional MRI (fMRI) and electroencephalogram (EEG) to better understand neural connectivity as a consequence of chronic pain in SCD patients. We performed independent component analysis and seed-based connectivity on fMRI data...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28115636/ensemble-simulations-folding-unfolding-and-misfolding-of-a-high-efficiency-frameshifting-rna-pseudoknot
#11
Khai K Q Nguyen, Yessica K Gomez, Mona Bakhom, Amethyst Radcliffe, Phuc La, Dakota Rochelle, Ji Won Lee, Eric J Sorin
Massive all-atom molecular dynamics simulations were conducted across a distributed computing network to study the folding, unfolding, misfolding and conformational plasticity of the high-efficiency frameshifting double mutant of the 26 nt potato leaf roll virus RNA pseudoknot. Our robust sampling, which included over 40 starting structures spanning the spectrum from the extended unfolded state to the native fold, yielded nearly 120 μs of cumulative sampling time. Conformational microstate transitions on the 1...
January 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28071918/stereoelectronic-effect-induced-conductance-switching-in-aromatic-chain-single-molecule-junctions
#12
Na Xin, Jinying Wang, Chuancheng Jia, Zitong Liu, Xisha Zhang, Chenmin Yu, Mingliang Li, Shuopei Wang, Yao Gong, Hantao Sun, Guanxin Zhang, Zhirong Liu, Guangyu Zhang, Jianhui Liao, Deqing Zhang, Xuefeng Guo
Biphenyl, as the elementary unit of organic functional materials, has been widely used in electronic and optoelectronic devices. However, over decades little has been fundamentally understood regarding how the intramolecular conformation of biphenyl dynamically affects its transport properties at the single-molecule level. Here, we establish the stereoelectronic effect of biphenyl on its electrical conductance based on the platform of graphene-molecule single-molecule junctions, where a specifically designed hexaphenyl aromatic chain molecule is covalently sandwiched between nanogapped graphene point contacts to create stable single-molecule junctions...
January 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28030720/bleb-morphology-after-needling-with-viscoelastic-of-an-ab-interno-microstent-assessed-by-optical-coherence-tomography
#13
Andrei-Alexandru Szigiato, Matthew Schlenker, Iqbal Ike K Ahmed
No abstract text is available yet for this article.
January 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28007612/low-motivational-incongruence-predicts-successful-eeg-resting-state-neurofeedback-in-healthy-adults
#14
Laura Diaz Hernandez, Kathryn Rieger, Thomas Koenig
Neurofeedback is becoming increasingly sophisticated and widespread, although predictors of successful performance still remain scarce. Here, we explored the possible predictive value of psychological factors and report the results obtained from a neurofeedback training study designed to enhance the self-regulation of spontaneous EEG microstates of a particular type (microstate class D). Specifically, we were interested in life satisfaction (including motivational incongruence), body awareness, personality and trait anxiety...
December 20, 2016: Neuroscience
https://www.readbyqxmd.com/read/28007553/shannon-information-entropy-in-the-canonical-genetic-code
#15
Louis R Nemzer
The Shannon entropy measures the expected information value of messages. As with thermodynamic entropy, the Shannon entropy is only defined within a system that identifies at the outset the collections of possible messages, analogous to microstates, that will be considered indistinguishable macrostates. This fundamental insight is applied here for the first time to amino acid alphabets, which group the twenty common amino acids into families based on chemical and physical similarities. To evaluate these schemas objectively, a novel quantitative method is introduced based the inherent redundancy in the canonical genetic code...
December 20, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28000675/suppressed-ion-scale-turbulence-in-a-hot-high-%C3%AE-plasma
#16
L Schmitz, D P Fulton, E Ruskov, C Lau, B H Deng, T Tajima, M W Binderbauer, I Holod, Z Lin, H Gota, M Tuszewski, S A Dettrick, L C Steinhauer
An economic magnetic fusion reactor favours a high ratio of plasma kinetic pressure to magnetic pressure in a well-confined, hot plasma with low thermal losses across the confining magnetic field. Field-reversed configuration (FRC) plasmas are potentially attractive as a reactor concept, achieving high plasma pressure in a simple axisymmetric geometry. Here, we show that FRC plasmas have unique, beneficial microstability properties that differ from typical regimes in toroidal confinement devices. Ion-scale fluctuations are found to be absent or strongly suppressed in the plasma core, mainly due to the large FRC ion orbits, resulting in near-classical thermal ion confinement...
December 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27967070/anomalous-structural-transition-of-confined-hard-squares
#17
Péter Gurin, Szabolcs Varga, Gerardo Odriozola
Structural transitions are examined in quasi-one-dimensional systems of freely rotating hard squares, which are confined between two parallel walls. We find two competing phases: one is a fluid where the squares have two sides parallel to the walls, while the second one is a solidlike structure with a zigzag arrangement of the squares. Using transfer matrix method we show that the configuration space consists of subspaces of fluidlike and solidlike phases, which are connected with low probability microstates of mixed structures...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27933418/temporal-characteristics-of-eeg-microstates-mediate-trial-by-trial-risk-taking
#18
Andreas Pedroni, Lorena R R Gianotti, Thomas Koenig, Dietrich Lehmann, Pascal Faber, Daria Knoch
People seem to have difficulties when perceiving events whose outcome has no influence on the outcome of future events. This illusion that patterns exist where there are none may lead to adverse consequences, such as escalating losses in financial trading or gambling debt. Despite the enormous social consequences of these cognitive biases, however, their neural underpinnings are poorly understood. Attempts to investigate them have so far relied on evoked neural activity, whereas spontaneous brain activity has been treated as noise to be averaged out...
January 2017: Brain Topography
https://www.readbyqxmd.com/read/27913138/compared-in%C3%A2-vivo-efficiency-of-nanoemulsions-unloaded-and-loaded-with-calixarene-and-soapy-water-in-the-treatment-of-superficial-wounds-contaminated-by-uranium
#19
COMPARATIVE STUDY
Sophie Grivès, Guillaume Phan, Céline Bouvier-Capely, David Suhard, François Rebière, Michelle Agarande, Elias Fattal
No emergency decontamination treatment is currently available in the case of radiological skin contamination by uranium compounds. First responders in the workplace or during an industrial nuclear accident must be able to treat internal contamination through skin. For this purpose, a calixarene nanoemulsion was developed for the treatment of intact skin or superficial wounds contaminated by uranium, and the decontamination efficiency of this nanoemulsion was investigated in vitro and ex vivo. The present work addresses the in vivo decontamination efficiency of this nanoemulsion, using a rat model...
April 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27886509/smooth-horizonless-geometries-deep-inside-the-black-hole-regime
#20
Iosif Bena, Stefano Giusto, Emil J Martinec, Rodolfo Russo, Masaki Shigemori, David Turton, Nicholas P Warner
We construct the first family of horizonless supergravity solutions that have the same mass, charges, and angular momenta as general supersymmetric rotating D1-D5-P black holes in five dimensions. This family includes solutions with arbitrarily small angular momenta, deep within the regime of quantum numbers and couplings for which a large classical black hole exists. These geometries are well approximated by the black-hole solution, and in particular exhibit the same near-horizon throat. Deep in this throat, the black-hole singularity is resolved into a smooth cap...
November 11, 2016: Physical Review Letters
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