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https://www.readbyqxmd.com/read/28086875/learning-global-health-a-pilot-study-of-an-online-collaborative-intercultural-peer-group-activity-involving-medical-students-in-australia-and-indonesia
#1
Mark Ambrose, Linda Murray, Nicholas E Handoyo, Deif Tunggal, Nick Cooling
BACKGROUND: There is limited research to inform effective pedagogies for teaching global health to undergraduate medical students. Theoretically, using a combination of teaching pedagogies typically used in 'international classrooms' may prove to be an effective way of learning global health. This pilot study aimed to explore the experiences of medical students in Australia and Indonesia who participated in a reciprocal intercultural participatory peer e-learning activity (RIPPLE) in global health...
January 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28070582/grain-boundary-mediated-nanopores-in-molybdenum-disulfide-grown-by-chemical-vapor-deposition
#2
Kenan Elibol, Toma Susi, Maria O Brien, Bernhard C Bayer, Timothy J Pennycook, Niall McEvoy, Georg S Duesberg, Jannik C Meyer, Jani Kotakoski
Molybdenum disulfide (MoS2) is a particularly interesting member of the family of two-dimensional (2D) materials due to its semiconducting and tunable electronic properties. Currently, the most reliable method for obtaining high-quality industrial scale amounts of 2D materials is chemical vapor deposition (CVD), which results in polycrystalline samples. As grain boundaries (GBs) are intrinsic defect lines within CVD-grown 2D materials, their atomic structure is of paramount importance. Here, through atomic-scale analysis of micrometer-long GBs, we show that covalently bound boundaries in 2D MoS2 tend to be decorated by nanopores...
January 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067903/modulation-of-excitation-on-parvalbumin-interneurons-by-neuroligin-3-regulates-the-hippocampal-network
#3
Jai S Polepalli, Hemmings Wu, Debanjan Goswami, Casey H Halpern, Thomas C Südhof, Robert C Malenka
Hippocampal network activity is generated by a complex interplay between excitatory pyramidal cells and inhibitory interneurons. Although much is known about the molecular properties of excitatory synapses on pyramidal cells, comparatively little is known about excitatory synapses on interneurons. Here we show that conditional deletion of the postsynaptic cell adhesion molecule neuroligin-3 in parvalbumin interneurons causes a decrease in NMDA-receptor-mediated postsynaptic currents and an increase in presynaptic glutamate release probability by selectively impairing the inhibition of glutamate release by presynaptic Group III metabotropic glutamate receptors...
January 9, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28063269/novel-mapping-technique-for-localization-of-focal-and-reentrant-activation-during-atrial-fibrillation
#4
Yoshihide Takahashi, Shinsuke Iwai, Syu Yamashita, Mayumi Masumura, Masahito Suzuki, Kento Yabe, Yasuhiro Sato, Kenzo Hirao, Mitsuaki Isobe
INTRODUCTION: Identification of wavefront propagation pattern during AF remains challenging in ablation procedures. We sought to test a novel combination of a new mapping technology called Ripple Map and high density mapping to distinguish focal and reentrant activation during atrial fibrillation (AF). METHODS AND RESULTS: Subjects were patients undergoing ablation for persistent AF. If AF remained after isolation of the pulmonary veins, the left atrium (LA) was mapped by a high-density mapping catheter for later analysis, after which ablation was continued using a conventional stepwise approach...
January 7, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28060451/a-controlled-design-of-ripple-like-polyamide-6-nanofiber-nets-membrane-for-high-efficiency-air-filter
#5
Shichao Zhang, Hui Liu, Fenglei Zuo, Xia Yin, Jianyong Yu, Bin Ding
The filtration capacity of fibrous media for airborne particles is restricted by their thick diameter, low porosity, and limited frontal area. The ability to solve this problem would have broad technological implications for various air filtration applications; despite many past efforts, it remains a great challenge to achieve. Herein, a facile and scalable strategy to fabricate the ripple-like polyamide-6 nanofiber/nets (PA-6 NF/N) air filter via combining electrospinning/netting technique with receiving substrate design is demonstrated...
January 6, 2017: Small
https://www.readbyqxmd.com/read/28058428/incorporation-of-aspirin-modulates-the-dynamical-and-phase-behavior-of-the-phospholipid-membrane
#6
V K Sharma, E Mamontov, M Ohl, M Tyagi
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used medications in the world for their analgesic, antipyretic, and anti-inflammatory actions, despite a well-known incidence of a wide spectrum of their adverse effects. To a great extent, beneficial action and side effects of NSAIDs are associated with the interaction of these drugs at the cell membrane level. Here, we use neutron scattering to combine elastic intensity scans, quasielastic and neutron spin echo (NSE) measurements to understand the effect of aspirin, a commonly used NSAID, on the dynamical and phase behavior of the membrane of dimyristoylphosphatidylcholine (DMPC), a prominent representative of phospholipids residing in the outer leaflet of the human erythrocyte membrane...
January 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28055919/optimal-switching-of-dc-dc-power-converters-using-approximate-dynamic-programming
#7
Ali Heydari
Optimal switching between different topologies in step-down dc-dc voltage converters, with nonideal inductors and capacitors, is investigated in this paper. Challenges including constraint on the inductor current and voltage leakages across the capacitor (due to switching) are incorporated. The objective is generating the desired voltage with low ripples and high robustness toward line and load disturbances. A previously developed tool, which is based on approximate dynamic programming, is adapted for this application...
December 29, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28052244/brain-state-dependence-of-hippocampal-subthreshold-activity-in-awake-mice
#8
Brad K Hulse, Evgueniy V Lubenov, Athanassios G Siapas
Monitoring the membrane potential of individual neurons has uncovered how single-cell properties contribute to network processing across different brain states in neocortex. In contrast, the subthreshold modulation of hippocampal neurons by brain state has not been systematically characterized. To address this, we combined whole-cell recordings from dentate granule cells and CA1 pyramidal neurons with multisite extracellular recordings and behavioral measurements in awake mice. We show that the average membrane potential, amplitude of subthreshold fluctuations, and distance to spike threshold are all modulated by brain state...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28050973/behavioral-state-classification-in-epileptic-brain-using-intracranial-electrophysiology
#9
Vaclav Kremen, Juliano Duque, Benjamin Brinkmann, Brent Berry, Michal Kucewicz, Fatemeh Khadjevand, Jamie Van Gompel, Squire Stead, Erik St Louis, Gregory A Worrell
OBJECTIVE: Automated behavioral state classification can benefit next generation implantable epilepsy devices. In this study we explored the feasibility of automated awake (AW) and slow wave sleep (SWS) classification using wide bandwidth intracranial EEG (iEEG) in patients undergoing evaluation for epilepsy surgery. APPROACH: Data from seven patients (age 34+/-12, 4 women, 5 right handed) who underwent intracranial depth electrode implantation for iEEG monitoring were included...
January 4, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28043201/physiological-ripples-associated-with-sleep-spindles-differ-in-waveform-morphology-from-epileptic-ripples
#10
Jonas C Bruder, Matthias Dümpelmann, Daniel Lachner Piza, Malenka Mader, Andreas Schulze-Bonhage, Julia Jacobs-Le Van
High frequency oscillations (HFOs, 80-500[Formula: see text]Hz) serve as novel electroencephalography (EEG) markers of epileptic tissue. The differentiation of physiological and epileptic HFO is an important challenge and is complicated by the fact that both types are generated in mesiotemporal structures. This study aimed to identify oscillation features that serve to distinguish physiological ripples associated with sleep spindles and epileptic ripples. We studied 19 patients with chronic intracranial EEG(iEEG) with mesiotemporal implantation and simultaneous scalp EEG...
November 2, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28041883/phase-locked-inhibition-but-not-excitation-underlies-hippocampal-ripple-oscillations-in-awake-mice-in%C3%A2-vivo
#11
Jian Gan, Shih-Ming Weng, Alejandro J Pernía-Andrade, Jozsef Csicsvari, Peter Jonas
Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation during non-rapid eye movement sleep, immobility, and consummatory behavior. However, whether temporally modulated synaptic excitation or inhibition underlies the ripples is controversial. To address this question, we performed simultaneous recordings of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs, inhibition dominated over excitation, with a peak conductance ratio of 4...
December 22, 2016: Neuron
https://www.readbyqxmd.com/read/28041797/sharp-wave-ripples-in-primates-are-enhanced-near-remembered-visual-objects
#12
Timothy K Leonard, Kari L Hoffman
The hippocampus plays an important role in memory for events that are distinct in space and time. One of the strongest, most synchronous neural signals produced by the hippocampus is the sharp-wave ripple (SWR), observed in a variety of mammalian species during offline behaviors, such as slow-wave sleep [1-3] and quiescent waking and pauses in exploration [4-8], leading to long-standing and widespread theories of its contribution to plasticity and memory during these inactive or immobile states [9-14]. Indeed, during sleep and waking inactivity, hippocampal SWRs in rodents appear to support spatial long-term and working memory [4, 15-23], but so far, they have not been linked to memory in primates...
December 21, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/28039998/effects-of-spectral-smearing-on-performance-of-the-spectral-ripple-and-spectro-temporal-ripple-tests
#13
Vijaya Kumar Narne, Mridula Sharma, Bram Van Dun, Shalini Bansal, Latika Prabhu, Brian C J Moore
The main aim of this study was to use spectral smearing to evaluate the efficacy of a spectral ripple test (SRt) using stationary sounds and a recent variant with gliding ripples called the spectro-temporal ripple test (STRt) in measuring reduced spectral resolution. In experiment 1 the highest detectable ripple density was measured using four amounts of spectral smearing (unsmeared, mild, moderate, and severe). The thresholds worsened with increasing smearing and were similar for the SRt and the STRt across the three conditions with smearing...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28035679/incorporating-single-cell-contribution-into-network-models-of-ripple-generation
#14
Azahara Oliva, Antonio Fernandez-Ruiz
No abstract text is available yet for this article.
January 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28032163/transition-from-round-to-shaped-implants-in-immediate-breast-reconstruction-our-preferred-approach-and-clinical-outcomes
#15
Thomas A Imahiyerobo, Kevin H Small, Robyn Sackeyfio, Hannah Hoffman, Mia Talmor
BACKGROUND: Smooth, round, silicone implants predominate device-based breast reconstruction in the USA; despite their prevalence, complications can include bottoming out, superior contour deformity, rippling, and/or lateral malposition. This complication profile increases the need for revision surgery and subsequent patient dissatisfaction. With the resurgence of shaped, textured, silicone implants in the USA, we report the senior author's success with these devices and outline a strategy to optimize outcomes in breast reconstruction surgery...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28027223/staged-suprapectoral-expander-implant-reconstruction-without-acellular-dermal-matrix-following-nipple-sparing-mastectomy
#16
Arthur H Salibian, Jay K Harness, Donald S Mowlds
BACKGROUND: Since the introduction of nipple-sparing mastectomy as an oncologically safe procedure for the treatment of breast cancer, reconstructive efforts for immediate staged expander/implant reconstruction have focused on submuscular implantation with or without acellular dermal matrix. Suprapectoral reconstruction without acellular dermal matrix has received little attention in the reconstructive literature of nipple-sparing mastectomy. METHODS: Between 2005 and 2015, 155 patients (250 breasts) underwent nipple-sparing mastectomy with prepectoral staged expander/implant reconstruction using thick mastectomy skin flaps without acellular dermal matrix...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28027080/carcinoid-like-labyrinthine-pattern-in-sebaceous-neoplasms-represents-a-sebaceous-mantle-phenotype-immunohistochemical-analysis-of-aberrant-vimentin-expression-and-cytokeratin-20-positive-merkel-cell-distribution
#17
Keisuke Goto, Takashi Anan, Takaya Fukumoto, Tetsunori Kimura, Noriyuki Misago
This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28026152/harnessing-three-dimensional-anatomy-of-graphene-foam-to-induce-superior-damping-in-hierarchical-polyimide-nanostructures
#18
Pranjal Nautiyal, Benjamin Boesl, Arvind Agarwal
Graphene foam-based hierarchical polyimide composites with nanoengineered interface are fabricated in this study. Damping behavior of graphene foam is probed for the first time. Multiscale mechanisms contribute to highly impressive damping in graphene foam. Rippling, spring-like interlayer van der Waals interactions and flexing of graphene foam branches are believed to be responsible for damping at the intrinsic, interlayer and anatomical scales, respectively. Merely 1.5 wt% graphene foam addition to the polyimide matrix leads to as high as ≈300% improvement in loss tangent...
December 27, 2016: Small
https://www.readbyqxmd.com/read/28024615/surface-characterization-and-antibacterial-response-of-silver-nanowire-arrays-supported-on-laser-treated-polyethylene-naphthalate
#19
M Polívková, V Štrublová, T Hubáček, S Rimpelová, V Švorčík, J Siegel
Polymeric biomaterials with antibacterial effects are requisite materials in the fight against hospital-acquired infections. An effective way for constructing a second generation of antibacterials is to exploit the synergic effect of (i) patterning of polymeric materials by a laser, and (ii) deposition of noble metals in their nanostructured forms. With this approach, we prepared highly-ordered periodic structures (ripples) on polyethylene naphthalate (PEN). Subsequent deposition of Ag under the glancing angle of 70° resulted in the formation of self-organized, fully separated Ag nanowire (Ag NW) arrays homogenously distributed on PEN surface...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28005864/phase-rainbow-refractometry-for-accurate-droplet-variation-characterization
#20
Yingchun Wu, Jantarat Promvongsa, Sawitree Saengkaew, Xuecheng Wu, Jia Chen, Gérard Gréhan
We developed a one-dimensional phase rainbow refractometer for the accurate trans-dimensional measurements of droplet size on the micrometer scale as well as the tiny droplet diameter variations at the nanoscale. The dependence of the phase shift of the rainbow ripple structures on the droplet variations is revealed. The phase-shifting rainbow image is recorded by a telecentric one-dimensional rainbow imaging system. Experiments on the evaporating monodispersed droplet stream show that the phase rainbow refractometer can measure the tiny droplet diameter changes down to tens of nanometers...
October 15, 2016: Optics Letters
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