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https://www.readbyqxmd.com/read/29454643/proprioceptive-stimuli-and-habit-formation-interresponse-time-mediated-behavior-in-cd-1-mice
#1
J Mark Cleaveland, Anna Roselle, Delaney K Fischer
The consolidation of behavioral sequences into relatively ballistic habits is thought to involve the formation of stimulus - response associations. Typically, the stimuli in these associations are assumed to be exteroceptive, i.e., external to the organism. However, responses, themselves, also possess stimulus properties that can mediate behavior. Indeed, these "proprioceptive cues" have long been hypothesized to underlie habit formation (Hull, 1934a, 1934b). One such stimulus involves the time durations between responses - a stimulus termed interresponse time (IRT)...
February 15, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29439462/physicochemical-properties-and-oxidative-storage-stability-of-milled-roselle-hibiscus-sabdariffa-l-seeds
#2
Nurul Hanisah Juhari, Mikael Agerlin Petersen
Milled Roselle ( Hibiscus sabdariffa L.) seeds of the UMKL cultivar were analyzed for proximate composition, water and oil absorption capacity, and the influence of storage conditions on storage stability. The storage stability was determined under four types of conditions: light/oxygen (air) (LO), light/nitrogen (LN), darkness/oxygen (air) (DO), and darkness/nitrogen (DN) while monitoring for seven consecutive months. During the storage period, the formation of volatiles was determined using dynamic headspace sampling and Gas Chromatography-Mass Spectrometry (GC-MS) analysis...
February 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29426649/rest-and-stress-longitudinal-systolic-left-ventricular-mechanics-in-hypertrophic-cardiomyopathy-implications-for-prognostication
#3
Iraklis Pozios, Aurelio Pinheiro, Celia Corona-Villalobos, Lars L Sorensen, Zeina Dardari, Hong-Yun Liu, Kenneth Cresswell, Susan Phillip, David A Bluemke, Stefan L Zimmerman, M Roselle Abraham, Theodore P Abraham
BACKGROUND: Exercise intolerance is the most common symptom in hypertrophic cardiomyopathy (HCM). We examined whether inability to augment myocardial mechanics during exercise would influence functional performance and clinical outcomes in HCM. METHODS: Ninety-five HCM patients (32 nonobstructive, 32 labile-obstructive, 31 obstructive) and 26 controls of similar age and gender distribution were recruited prospectively. They underwent rest and treadmill stress strain echocardiography, and 61 of them underwent magnetic resonance imaging...
February 6, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29423907/correction-to-comparison-of-two-software-systems-for-quantification-of-myocardial-blood-flow-in-patients-with-hypertrophic-cardiomyopathy
#4
Hulya Yalcin, Ines Valenta, Min Zhao, Abdel Tahari, Dai-Yin Lu, Takahiro Higuchi, Fatih Yalcin, Nagehan Kucukler, Yalda Soleimanifard, Yun Zhou, Martin G Pomper, Theodore P Abraham, Ben Tsui, Martin A Lodge, Thomas H Schindler, M Roselle Abraham
The following information is missing from the Funding footnote on the first page of the published article: "This study was partly funded by NIH RO1 HL092985." The last/corresponding author is incorrectly listed on the first page of the published article: The correct name is Abraham MR.
February 8, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29412917/comparative-analysis-of-hibiscus-sabdariffa-roselle-hot-and-cold-extracts-in-respect-to-their-potential-for-%C3%AE-glucosidase-inhibition
#5
Dalia M Rasheed, Andrea Porzel, Andrei Frolov, Hesham R El Seedi, Ludger A Wessjohann, Mohamed A Farag
Roselle (Hibiscus sabdariffa) is a functional food with potential health benefits, consumed either as hot or cold beverage. To ensure quality control of its various products, accurate measurement of active metabolites is warranted. Herein, we propose a combination of ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and nuclear magnetic resonance (NMR) analytical platforms for the untargeted characterization of metabolites in two roselle cultivars, Aswan and Sudan-1. The analyses revealed 33 metabolites, including sugars, flavonoids, anthocyanins, phenolic and aliphatic organic acids...
June 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29371602/ampk-activation-counteracts-cardiac-hypertrophy-by-reducing-o-glcnacylation
#6
Roselle Gélinas, Florence Mailleux, Justine Dontaine, Laurent Bultot, Bénédicte Demeulder, Audrey Ginion, Evangelos P Daskalopoulos, Hrag Esfahani, Emilie Dubois-Deruy, Benjamin Lauzier, Chantal Gauthier, Aaron K Olson, Bertrand Bouchard, Christine Des Rosiers, Benoit Viollet, Kei Sakamoto, Jean-Luc Balligand, Jean-Louis Vanoverschelde, Christophe Beauloye, Sandrine Horman, Luc Bertrand
AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ribosomal S6 protein kinase, calcineurin/nuclear factor of activated T cells (NFAT) and extracellular signal-regulated kinases. Instead, cardiomyocyte hypertrophy is accompanied by increased protein O-GlcNAcylation, which is reversed by AMPK activation. Decreasing O-GlcNAcylation by inhibitors of the glutamine:fructose-6-phosphate aminotransferase (GFAT), blocks cardiomyocyte hypertrophy, mimicking AMPK activation...
January 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29359273/comparison-of-two-software-systems-for-quantification-of-myocardial-blood-flow-in-patients-with%C3%A2-hypertrophic-cardiomyopathy
#7
Hulya Yalcin, Ines Valenta, Min Zhao, Abdel Tahari, Dai-Yin Lu, Takahiro Higuchi, Fatih Yalcin, Nagehan Kucukler, Yalda Soleimanifard, Yun Zhou, Martin G Pomper, Theodore P Abraham, Ben Tsui, Martin A Lodge, Thomas H Schindler, M Roselle Abraham
BACKGORUND: Quantification of myocardial blood flow (MBF) by positron emission tomography (PET) is important for investigation of angina in hypertrophic cardiomyopathy (HCM). Several software programs exist for MBF quantification, but they have been mostly evaluated in patients (with normal cardiac geometry), referred for evaluation of coronary artery disease (CAD). Software performance has not been evaluated in HCM patients who frequently have hyperdynamic LV function, LV outflow tract (LVOT) obstruction, small LV cavity size, and variation in the degree/location of LV hypertrophy...
January 22, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29357486/evolution-of-ventricular-hypertrophy-and-myocardial-mechanics-in-physiologic-and-pathologic-hypertrophy
#8
Fatih Yalcin, Nagehan Kucukler, Oscar H Cingolani, Blaid Mbiyangandu, Lars Sorensen, Aurelio Pinherio, Roselle Abraham, Theodore P Abraham
LEFT VENTRICULAR HYPERTROPHY (LVH) is an adaptive response to physiologic or pathologic stimuli and distinguishing between the two has obvious clinical implications. However, asymmetric septal hypertrophy and preserved cardiac function are noted in early stages in both cases. We characterized the early anatomic and functional changes in a mouse model of physiologic and pathologic stress using serial echocardiography-based morphometry and tissue velocity imaging. Weight-matched CF-1 male mice were separated into CONTROLS (n=10), treadmill EXERCISE 1 hour daily x 5 days/week (n=7) and transverse aortic constriction (TAC, n=7)...
January 4, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29352824/evaluating-the-effect-of-a-clostridium-difficile-infection-prevention-initiative-in-veterans-health-administration-long-term-care-facilities
#9
Maninder B Singh, Martin E Evans, Loretta A Simbartl, Stephen M Kralovic, Gary A Roselle
We evaluated rates of clinically confirmed long-term-care facility-onset Clostridium difficile infections from April 2014 through December 2016 in 132 Veterans Affairs facilities after the implementation of a prevention initiative. The quarterly pooled rate decreased 36.1% from the baseline (P<.0009 for trend) by the end of the analysis period. Infect Control Hosp Epidemiol 2018;1-3.
January 21, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29344101/healthcare-associated-legionnaires-disease-limitations-of-surveillance-definitions-and-importance-of-epidemiologic-investigation
#10
Laila M Castellino, Shantini D Gamage, Patti V Hoffman, Stephen M Kralovic, Mark Holodniy, Jack M Bernstein, Gary A Roselle
Healthcare-associated Legionnaires' disease (HCA LD) causes significant morbidity and mortality, with varying guidance on prevention. We describe the evaluation of a case of possible HCA LD and note the pitfalls of relying solely on an epidemiologic definition for association of a case with a facility. Our detailed investigation led to the identification of a new Legionella pneumophila serogroup 1 sequence type, confirmed a healthcare association and helped build the framework for our ongoing preventive efforts...
November 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29320233/antibacterial-activities-of-hibiscus-sabdariffa-extracts-and-chemical-sanitizers-directly-on-green-leaves-contaminated-with-foodborne-pathogens
#11
Carlos A Gómez-Aldapa, Esmeralda Rangel-Vargas, Ma Refugio Torres-Vitela, Angélica Villarruel-López, Otilio A Acevedo-Sandoval, Alberto J Gordillo-Martínez, Angélica Godínez-Oviedo, Javier Castro-Rosas
Leafy greens have been associated with foodborne disease outbreaks in different countries. To decrease microbial contamination of leafy greens, chemical agents are commonly used; however, a number of studies have shown these agents to have limited antimicrobial effect against pathogenic bacteria on vegetables. The objective of this study was to compare the antibacterial effect of Hibiscus sabdariffa calyx extracts (water, methanol, acetone, and ethyl acetate), sodium hypochlorite, acetic acid, and colloidal silver against foodborne bacteria on leafy greens...
January 10, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29201276/antihypertensive-effects-of-roselle-olive-combination-in-l-name-induced-hypertensive-rats
#12
Rehab F Abdel-Rahman, Alyaa F Hessin, Marwan Abdelbaset, Hanan A Ogaly, Reham M Abd-Elsalam, Salah M Hassan
This study aimed to evaluate the antihypertensive efficacy of a new combination therapy of Hibiscus sabdariffa and Olea europaea extracts (2 : 1; Roselle-Olive), using N(G)-nitro-L-arginine-methyl ester- (L-NAME-) induced hypertensive model. Rats received L-NAME (50 mg/kg/day, orally) for 4 weeks. Concurrent treatment with Roselle-Olive (500, 250, and 125 mg/kg/day for 4 weeks) resulted in a dose-dependent decrease in both systolic and diastolic blood pressure, reversed the L-NAME-induced suppression in serum nitric oxide (NO), and improved liver and kidney markers, lipid profile, and oxidative status...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29066253/roselle-is-cardioprotective-in-diet-induced-obesity-rat-model-with-myocardial-infarction
#13
Lislivia Yiang-Nee Si, Siti Aishah Mohd Ali, Jalifah Latip, Norsyahida Mohd Fauzi, Siti Balkis Budin, Satirah Zainalabidin
AIMS: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. MAIN METHODS: Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s...
December 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/29021306/characterization-of-a-human-induced-pluripotent-stem-cell-derived-cardiomyocyte-model-for-the-study-of-variant-pathogenicity-validation-of-a-kcnj2-mutation
#14
Roselle Gélinas, Nabil El Khoury, Marie-A Chaix, Claudine Beauchamp, Azadeh Alikashani, Nathalie Ethier, Gabrielle Boucher, Louis Villeneuve, Laura Robb, Frédéric Latour, Blandine Mondesert, Lena Rivard, Philippe Goyette, Mario Talajic, Céline Fiset, John David Rioux
BACKGROUND: Long-QT syndrome is a potentially fatal condition for which 30% of patients are without a genetically confirmed diagnosis. Rapid identification of causal mutations is thus a priority to avoid at-risk situations that can lead to fatal cardiac events. Massively parallel sequencing technologies are useful for the identification of sequence variants; however, electrophysiological testing of newly identified variants is crucial to demonstrate causality. Long-QT syndrome could, therefore, benefit from having a standardized platform for functional characterization of candidate variants in the physiological context of human cardiomyocytes...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28977350/e-e-ratio-and-outcome-prediction-in-hypertrophic-cardiomyopathy-the-influence-of-outflow-tract-obstruction
#15
Dai-Yin Lu, Bereketeab Hailesealassie, Ioannis Ventoulis, Hong-Yun Liu, Hsin-Yueh Liang, Iraklis Pozios, Marco Canepa, Susan Phillip, M Roselle Abraham, Theodore Abraham
Aims: Diastolic dysfunction is thought to be an important pathophysiologic component of hypertrophic cardiomyopathy (HCM). However, there are conflicting data on the potential value of the mitral E/e' ratio. We examined whether left ventricular outflow tract (LVOT) obstruction influences the value of E/e' in predicting outcomes in HCM. Methods and results: Patients who met diagnostic criteria for HCM were enrolled. Diastolic function was assessed with complete two-dimensional and Doppler echocardiography...
July 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28947624/development-and-application-of-an-objective-staffing-calculator-for-antimicrobial-stewardship-programs-in-the-veterans-health-administration
#16
Kelly Echevarria, Julie Groppi, Allison A Kelly, Anthony P Morreale, Melinda M Neuhauser, Gary A Roselle
PURPOSE: The development and validation of a staffing calculator and its use in creating staffing guidance for antimicrobial stewardship programs (ASPs) in Veterans Health Administration (VHA) facilities are described. METHODS: The Tools and Resources Work Group of the Antimicrobial Stewardship Task Force and PBM Clinical Pharmacy Practice Office of the Department of Veterans Affairs developed, tested, and validated a staffing calculator to track patient care and ASP management activities needed to maintain a comprehensive ASP...
November 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28747034/impact-of-peak-provoked-left-ventricular-outflow-tract-gradients-on-clinical-outcomes-in-hypertrophic-cardiomyopathy
#17
Dai-Yin Lu, Bereketeab Hailesealassie, Ioannis Ventoulis, Hongyun Liu, Hsin-Yueh Liang, Alexandra Nowbar, Iraklis Pozios, Marco Canepa, Kenneth Cresswell, Hong-Chang Luo, M Roselle Abraham, Theodore P Abraham
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is traditionally classified based on a left ventricular outflow tract (LVOT) pressure gradient of 30mmHg at rest or with provocation. There are no data on whether 30mmHg is the most informative cut-off value and whether provoked gradients offer any information regarding outcomes. METHODS: Resting and provoked peak LVOT pressure gradients were measured by Doppler echocardiography in patients fulfilling guidelines criteria for HCM...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28720929/antioxidant-characteristics-of-extracts-of-hibiscus-sabdariffa-calyces-encapsulated-with-mesquite-gum
#18
C E Ochoa-Velasco, C Salazar-González, S Cid-Ortega, J A Guerrero-Beltrán
This study compared the stability of extracts of H. sabdariffa calyces microencapsulated with different concentrations of mesquite gum during storage. Dry Roselle calyces were mixed with 50:50 (v/v) ethanol:water solution to obtain 18°Bx concentrate. This Roselle extract concentrate was mixed with purified mesquite gum (100:1-100:5 v/w). The Roselle extract concentrate-gum (RECG) was spray dried at inlet and outlet temperatures of 180 ± 2 and 104 ± 2.3 °C, respectively, at an air flow rate of 38 m(3)/h...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28693429/plasma-homocysteine-levels-associated-with-a-corrected-qt-interval
#19
Zhao Li, Xiaofan Guo, Guozhe Sun, Liqiang Zheng, Yingxian Sun, Yamin Liu, Maria Roselle Abraham
BACKGROUND: Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. METHODS: Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. RESULTS: The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11...
July 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28687124/role-of-global-longitudinal-strain-in-predicting-outcomes-in-hypertrophic-cardiomyopathy
#20
Hongyun Liu, Iraklis Pozios, Bereketeab Haileselassie, Alexandra Nowbar, Lars L Sorensen, Susan Phillip, Dai-Yin Lu, Ioannis Ventoulis, Hongchang Luo, M Roselle Abraham, Theodore P Abraham
Global longitudinal strain (GLS) is a sensitive indicator of global left ventricular function particularly in those with normal ejection fraction. We examined the potential value of GLS in predicting outcomes in hypertrophic cardiomyopathy (HC). Conventional and strain echocardiography was performed in 400 patients with HC followed for a median 3.1 years (interquartile range 1.2 to 5.6). Peak systolic strain from 3 apical views was averaged to calculate GLS. Patients were divided based on a previously published cutoff value of -16%...
August 15, 2017: American Journal of Cardiology
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