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Malka N Halgamuge
AIM: The aim of this article was to explore the hypothesis that non-thermal, weak, radiofrequency electromagnetic fields (RF-EMF) have an effect on living plants. SUBJECT AND METHODS: In this study, we performed an analysis of the data extracted from the 45 peer-reviewed scientific publications (1996-2016) describing 169 experimental observations to detect the physiological and morphological changes in plants due to the non-thermal RF-EMF effects from mobile phone radiation...
September 20, 2016: Electromagnetic Biology and Medicine
Zhao Li, Xiaofan Guo, Yamin Liu, Naijin Zhang, Ye Chang, Yintao Chen, Yingxian Sun, Maria Roselle Abraham
Little is known about stroke with different obesity phenotype as determined using the Adult Treatment Panel-III criteria with metabolic health or not. This study aimed to investigate the effects of metabolically healthy and unhealthy obesity on ischemic stroke in a general population. A total of 11,150 adults were examined using a multi-stage cluster sampling method to select a representative sample of individuals 35 years or older. Ischemic stroke was defined as history of a cerebrovascular event, as documented by doctors via either cranial CT or MR scan within the past 2 years...
2016: SpringerPlus
Florence Mailleux, Roselle Gélinas, Christophe Beauloye, Sandrine Horman, Luc Bertrand
O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine residues, which is evolving as an important mechanism for the regulation of various cellular processes. The present review will, first, provide a general background on the molecular regulation of protein O-GlcNAcylation and will summarize the role of this post-translational modification in various acute cardiac pathologies including ischemia-reperfusion. Then, we will focus on research studies examining protein O-GlcNAcylation in the context of cardiac hypertrophy...
August 17, 2016: Biochimica et Biophysica Acta
Lars L Sørensen, Djahida Bedja, Polina Sysa-Shah, Hongyun Liu, Amanda Maxwell, Xu Yi, Iraklis Pozios, Niels T Olsen, Theodore P Abraham, Roselle Abraham, Kathleen Gabrielson
Although rare, hypertrophic cardiomyopathy (HCM) with midventricular obstruction is often associated with severe symptoms and complications. None of the existing HCM animal models display this particular phenotype. Our group developed a mouse line that overexpresses the ErbB2 receptor (ErbB2(tg)) in cardiomyocytes; we previously showed that the ErbB2 receptor induces cardiomyocyte hypertrophy, myocyte disarray, and fibrosis compatible with HCM. In the current study, we sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of HCM...
2016: Comparative Medicine
Shantini D Gamage, Meredith Ambrose, Stephen M Kralovic, Gary A Roselle
Health care facility water distribution systems have been implicated in the transmission of pathogens such as Legionella and nontuberculous mycobacteria to building occupants. These pathogens are natural inhabitants of water at low numbers and can amplify in premise plumbing water, especially if conditions are conducive to their growth. Because patients and residents in health care facilities are often at heightened risk for opportunistic infections, a multidisciplinary proactive approach to water safety is important to balance the various water priorities in health care and prevent water-associated infections in building occupants...
September 2016: Infectious Disease Clinics of North America
André Sinela, Nadirah Rawat, Christian Mertz, Nawel Achir, Hélène Fulcrand, Manuel Dornier
Degradation parameters of two main anthocyanins from roselle extract (Hibiscus sabdariffa L.) stored at different temperatures (4-37°C) over 60days were determined. Anthocyanins and some of their degradation products were monitored and quantified using HPLC-MS and DAD. Degradation of anthocyanins followed first-order kinetics and reaction rate constants (k values), which were obtained by non-linear regression, showed that the degradation rate of delphinidin 3-O-sambubioside was higher than that of cyanidin 3-O-sambubioside with k values of 9...
January 1, 2017: Food Chemistry
Zhao Li, Xiaofan Guo, Yamin Liu, Ye Chang, Yingxian Sun, Guangshuo Zhu, Maria Roselle Abraham
BACKGROUND: although alcohol abuse is known to increase serum uric acid, the relation between moderate drinking and uric acid have remained poorly understood. We performed this study to evaluate whether different alcohol consumption level has different effects on the risk of hyperuricemia based on a rural general population. METHOD: multi-stage cluster sampling method was used to select a representative sample of individuals aged 35 years or older. Participants were asked to provide information about their alcohol consumption...
2016: International Journal of Environmental Research and Public Health
Tsung-Chang Tsai, Hui-Pei Huang, Kai-Ting Chang, Chau-Jong Wang, Yun-Ching Chang
Cell cycle regulation is an important issue in cancer therapy. Delphinidin and cyanidin are two major anthocyanins of the roselle plant (Hibiscus sabdariffa). In the present study, we investigated the effect of Hibiscus anthocyanins (HAs) on cell cycle arrest in human leukemia cell line HL-60 and the analyzed the underlying molecular mechanisms. HAs extracted from roselle calyces (purity 90%) markedly induced G2/M arrest evaluated with flow cytometry analysis. Western blot analyses revealed that HAs (0.1-0...
July 22, 2016: Environmental Toxicology
Ho Chang, Xuan-Rong Lai
This study aims to deal with the influence of different solvent in extraction of natural sensitizer and different thickness of photoelectrode thin film on the photoelectric conversion efficiency and the electron transport properties for the prepared dye-sensitized solar cells (DSSC). The natural dyes of anthocyanin and chlorophyll dyes are extracted from mixture of purple cabbage and roselle and mixture of wormwood and seaweed, respectively. The experimental results show the cocktail dye extracted with ethanol and rotating speed of spin coating at 1000 rpm can achieve the greatest photoelectric conversion efficiency up to 1...
February 2016: Journal of Nanoscience and Nanotechnology
Yi-Cheng Lim, Siti Balkis Budin, Faizah Othman, Jalifah Latip, Satirah Zainalabidin
Roselle (Hibiscus sabdariffa Linn.) calyces have demonstrated propitious cardioprotective effects in animal and clinical studies; however, little is known about its action on cardiac mechanical function. This study was undertaken to investigate direct action of roselle polyphenols (RP) on cardiac function in Langendorff-perfused rat hearts. We utilized RP extract which consists of 12 flavonoids and seven phenolic acids (as shown by HPLC profiling) and has a safe concentration range between 125 and 500 μg/ml in this study...
July 11, 2016: Cardiovascular Toxicology
Michihiko Goto, Amy M J O'Shea, Daniel J Livorsi, Jennifer S McDanel, Makoto M Jones, Kelly K Richardson, Brice F Beck, Bruce Alexander, Martin E Evans, Gary A Roselle, Stephen M Kralovic, Eli N Perencevich
BACKGROUND: The Veterans Health Administration (VHA) introduced the Methicillin-Resistant Staphylococcus aureus (MRSA) Prevention Initiative in March 2007. Although the initiative has been perceived as a vertical intervention focusing on MRSA, it also expanded infection prevention and control programs and resources. We aimed to assess the horizontal effect of the initiative on hospital-onset (HO) gram-negative rod (GNR) bacteremia. METHODS: This retrospective cohort included all patients who had HO bacteremia due to Escherichia coli, Klebsiella species, or Pseudomonas aeruginosa at 130 VHA facilities from January 2003 to December 2013...
September 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Thorsten Verch, Christopher Roselle, Mary Shank-Retzlaff
BACKGROUND: Dilution bias is a major cause of immunoassay variability due to the lack of an internal standard to determine the true versus the expected dilution value. METHODOLOGY: We used an internal control to measure dilution bias in an ELISA. Acridine-orange was added at the first dilution step and monitored throughout dilutions. Assay results were corrected using the fluorescent signal ratio between samples and reference. Acridine dilution correlated with analyte-specific assay measurements (R2 = 0...
July 2016: Bioanalysis
Zhao Li, Xiaofan Guo, Yinglong Bai, Guozhe Sun, Yufan Guan, Yingxian Sun, Abraham Maria Roselle
The results of previous studies on the relation between alcohol consumption and heart failure (HF) have been inconsistent. This study aimed to evaluate the association between alcohol consumption and left ventricular ejection fraction (LVEF) in a general population.A total of 10,824 adults were examined using a multistage cluster sampling method to select a representative sample of individuals who were at least 35-years old. The participants were asked to provide information about their alcohol consumption...
May 2016: Medicine (Baltimore)
Idolo Ifie, Lisa J Marshall, Peter Ho, Gary Williamson
Three varieties of Hibiscus sabdariffa were analyzed for their phytochemical content and inhibitory potential on carbohydrate-digesting enzymes as a basis for selecting a variety for wine production. The dark red variety was chosen as it was highest in phenolic content and an aqueous extract partially inhibited α-glucosidase (maltase), with delphinidin 3-O-sambubioside, cyanidin 3-O-sambubioside, and 3-O-caffeoylquinic acid accounting for 65% of this activity. None of the varieties significantly inhibited α-amylase...
June 22, 2016: Journal of Agricultural and Food Chemistry
Xiaoping Lin, Steven Steinberg, Suresh K Kandasamy, Junaid Afzal, Blaid Mbiyangandu, Susan E Liao, Yufan Guan, Celia P Corona-Villalobos, Scot J Matkovich, Neal Epstein, Dotti Tripodi, Zhaoxia Huo, Garry Cutting, Theodore P Abraham, Ryuya Fukunaga, M Roselle Abraham
MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized that genetic variations in miRNAs that regulate cardiac hypertrophy/fibrosis might be involved in generation of the cardiac phenotype in patients diagnosed with hypertrophic cardiomyopathy (HCM). To investigate this question, we Sanger sequenced 18 miRNA genes previously implicated in myocyte hypertrophy/fibrosis and apoptosis, using genomic DNA isolated from the leukocytes of 199 HCM patients...
2016: PloS One
Zhao Li, Yinglong Bai, Xiaofan Guo, Liqiang Zheng, Yingxian Sun, Abraham Marria Roselle
OBJECTIVES: This study aimed to update the current information on alcohol consumption and evaluate the associations between drinking status and cardiovascular diseases in a general population from rural China. METHODS: The study examined a total of 11,269 adults using a multi-stage cluster sampling method to select a representative sample of individuals 35years or older. Related medical histories were obtained using a standard questionnaire, and blood biochemical indexes were collected by well-trained personnel...
July 15, 2016: International Journal of Cardiology
Christopher Roselle, Thorsten Verch, Mary Shank-Retzlaff
Microtiter plate-based assays are a common tool in biochemical and analytical labs. Despite widespread use, results generated in microtiter plate-based assays are often impacted by positional bias, in which variability in raw signal measurements are not uniform in all regions of the plate. Since small positional effects can disproportionately affect assay results and the reliability of the data, an effective mitigation strategy is critical. Commonly used mitigation strategies include avoiding the use of outer regions of the plate, replicating treatments within and between plates, and randomizing placement of treatments within and between plates...
June 2016: Analytical and Bioanalytical Chemistry
Emad Mohamed Abdallah
BACKGROUND: Hibiscus sabdariffa L. is a plant native to tropical Africa and intensively cultivated in Sudan. Its calyces are widely consumed with many uses in Sudanese folk medicine. MATERIALS AND METHODS: The dried calyces of H. sabdariffa were subjected to soak in 80% v/v methanol to get the methanolic extract, which was tested against five Gram-negative and three Gram-positive referenced bacterial strains using disc diffusion method. Selected bioactive phytochemical compounds were also investigated using qualitative methods...
March 2016: Journal of Intercultural Ethnopharmacology
Malgorzata S Martin-Gronert, Claire J Stocker, Edward T Wargent, Roselle L Cripps, Alastair S Garfield, Zorica Jovanovic, Giuseppe D'Agostino, Giles S H Yeo, Michael A Cawthorne, Jonathan R S Arch, Lora K Heisler, Susan E Ozanne
No abstract text is available yet for this article.
April 15, 2016: Development
Alex Tai, Roselle Robosa, Alexander A Padiglione, Chamila Dalpatadu, Tony M Korman
No abstract text is available yet for this article.
April 18, 2016: Medical Journal of Australia
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