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https://www.readbyqxmd.com/read/27892886/safety-profile-and-utility-of-treadmill-exercise-in-patients-with-high-gradient-hypertrophic-cardiomyopathy
#1
Lars Lindholm Sorensen, Hsin-Yueh Liang, Aurelio Pinheiro, Alex Hilser, Veronica Dimaano, Niels Thue Olsen, Thomas Fritz Hansen, Peter Sogaard, Alexandra Nowbar, Chiara Pisanello, Iraklis Pozios, Susan Phillip, Xun Zhou, Roselle Abraham, Theodore P Abraham
: Exercise echocardiography in the evaluation of hypertrophic cardiomyopathy (HCM) provides valuable information for risk stratification, selection of optimal treatment, and prognostication. However, HCM patients with left ventricular outflow tract gradients ≥30mm Hg are often excluded from exercise testing because of safety considerations. We examined the safety and utility of exercise testing in patients with high-gradient HCM. METHODS: We evaluated clinical characteristics, hemodynamics, and imaging variables in 499 consecutive patients with HCM who performed 959 exercise tests...
October 20, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27871291/-a-rising-tide-lifts-all-boats-establishing-a-multidisciplinary-genomic-tumor-board-for-breast-cancer-patients-with-advanced-disease
#2
Michelle L McGowan, Roselle S Ponsaran, Paula Silverman, Lyndsay N Harris, Patricia A Marshall
BACKGROUND: Research suggests that multidisciplinary genomic tumor boards (MGTB) can inform cancer patient care, though little is known about factors influencing how MGTBs interpret genomic test results, make recommendations, and perceive the utility of this approach. This study's objective was to observe, describe, and assess the establishment of the Breast Multidisciplinary Genomic Tumor Board, the first MGTB focused on interpreting genomic test results for breast cancer patients with advanced disease...
November 21, 2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27861123/tecrl-a-new-life-threatening-inherited-arrhythmia-gene-associated-with-overlapping-clinical-features-of-both-lqts-and-cpvt
#3
Harsha D Devalla, Roselle Gélinas, Elhadi H Aburawi, Abdelaziz Beqqali, Philippe Goyette, Christian Freund, Marie-A Chaix, Rafik Tadros, Hui Jiang, Antony Le Béchec, Jantine J Monshouwer-Kloots, Tom Zwetsloot, Georgios Kosmidis, Frédéric Latour, Azadeh Alikashani, Maaike Hoekstra, Jurg Schlaepfer, Christine L Mummery, Brian Stevenson, Zoltan Kutalik, Antoine Af de Vries, Léna Rivard, Arthur Am Wilde, Mario Talajic, Arie O Verkerk, Lihadh Al-Gazali, John D Rioux, Zahurul A Bhuiyan, Robert Passier
Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole-exome sequencing (WES) was carried out on patients from three different families that presented with life-threatening arrhythmias and high risk of sudden cardiac death (SCD). Two French Canadian probands carried identical homozygous rare variant in TECRL gene (p.Arg196Gln), which encodes the trans-2,3-enoyl-CoA reductase-like protein. Both patients had cardiac arrest, stress-induced atrial and ventricular tachycardia, and QT prolongation on adrenergic stimulation...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27854262/diagnosed-but-not-undiagnosed-diabetes-is-associated-with-depression-in-rural-areas
#4
Zhao Li, Xiaofan Guo, Hongkun Jiang, Guozhe Sun, Yingxian Sun, Maria Roselle Abraham
Background: There is a lack of study on the relation between undiagnosed diabetes and depression in the general population. Methods: A total of 11,531 adults were examined using a multistage cluster sampling method to select a representative sample of individuals who were at least 35 years old. Subjects were classified into three groups: no diabetes (ND), diagnosed diabetes (DD), and undiagnosed diabetes (UD). The participants were surveyed with the Patient Health Questionnaire-9 (PHQ-9). Results: Of all the 11,531 participants, the prevalence of depression was higher in the DD group than in the other two groups...
November 14, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27773797/exploring-the-effect-and-mechanism-of-hibiscus-sabdariffa-on-urinary-tract-infection-and-experimental-renal-inflammation
#5
Shun-Ting Chou, Hsin-Yi Lo, Chia-Cheng Li, Lu-Chen Cheng, Pei-Chi Chou, Yu-Chen Lee, Tin-Yun Ho, Chien-Yun Hsiang
ETHNOPHARMACOLOGICAL RELEVANCE: Hibiscus sabdariffa Linn., also known as roselle, is used in folk medicine as an anti-inflammatory agent. Urinary tract infection (UTI) is a common problem in long-term care facilities. However, effects of roselle on UTI and renal inflammation remained to be analyzed. AIM: Here we surveyed the effect of roselle drink on the prevention of UTI in long-term care facilities and analyzed the anti-inflammatory potential of roselle on lipopolysaccharide (LPS)-induced renal inflammation in mice...
October 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27771003/effect-of-diffuse-subendocardial-hypoperfusion-on-left-ventricular-cavity-size-by-13-n-ammonia-perfusion-pet-in-patients-with-hypertrophic-cardiomyopathy
#6
Hulya Yalçin, Ines Valenta, Fatih Yalçin, Celia Corona-Villalobos, Nestor Vasquez, Joshua Ra, Nagehan Kucukler, Abdel Tahari, Iraklis Pozios, Yun Zhou, Martin Pomper, Theodore P Abraham, Thomas H Schindler, M Roselle Abraham
Vasodilator-induced transient left ventricular (LV) cavity dilation by positron emission tomography (PET) is common in patients with hypertrophic cardiomyopathy (HC). Because most patients with PET-LV cavity dilation lack obstructive epicardial coronary artery disease, we hypothesized that vasodilator-induced subendocardial hypoperfusion resulting from microvascular dysfunction underlies this result. To test this hypothesis, we quantified myocardial blood flow (MBF) (subepicardial, subendocardial, and global MBF) and left ventricular ejection fraction (LVEF) in 104 patients with HC without significant coronary artery disease, using (13)NH3-PET...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27650031/review-weak-radiofrequency-radiation-exposure-from-mobile-phone-radiation-on-plants
#7
Malka N Halgamuge
AIM: The aim of this article was to explore the hypothesis that non-thermal, weak, radiofrequency electromagnetic fields (RF-EMF) have an effect on living plants. SUBJECT AND METHODS: In this study, we performed an analysis of the data extracted from the 45 peer-reviewed scientific publications (1996-2016) describing 169 experimental observations to detect the physiological and morphological changes in plants due to the non-thermal RF-EMF effects from mobile phone radiation...
September 20, 2016: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27625973/metabolism-rather-than-obesity-is-associated-with-ischemic-stroke-a-cross-sectional-study-in-rural-northeastern-china
#8
Zhao Li, Xiaofan Guo, Yamin Liu, Naijin Zhang, Ye Chang, Yintao Chen, Yingxian Sun, Maria Roselle Abraham
Little is known about stroke with different obesity phenotype as determined using the Adult Treatment Panel-III criteria with metabolic health or not. This study aimed to investigate the effects of metabolically healthy and unhealthy obesity on ischemic stroke in a general population. A total of 11,150 adults were examined using a multi-stage cluster sampling method to select a representative sample of individuals 35 years or older. Ischemic stroke was defined as history of a cerebrovascular event, as documented by doctors via either cranial CT or MR scan within the past 2 years...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27544701/o-glcnacylation-enemy-or-ally-during-cardiac-hypertrophy-development
#9
Florence Mailleux, Roselle Gélinas, Christophe Beauloye, Sandrine Horman, Luc Bertrand
O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine residues, which is evolving as an important mechanism for the regulation of various cellular processes. The present review will, first, provide a general background on the molecular regulation of protein O-GlcNAcylation and will summarize the role of this post-translational modification in various acute cardiac pathologies including ischemia-reperfusion. Then, we will focus on research studies examining protein O-GlcNAcylation in the context of cardiac hypertrophy...
August 17, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27538857/echocardiographic-characterization-of-a-murine-model-of-hypertrophic-obstructive-cardiomyopathy-induced-by-cardiac-specific-overexpression-of-epidermal-growth-factor-receptor-2
#10
Lars L Sørensen, Djahida Bedja, Polina Sysa-Shah, Hongyun Liu, Amanda Maxwell, Xu Yi, Iraklis Pozios, Niels T Olsen, Theodore P Abraham, Roselle Abraham, Kathleen Gabrielson
Although rare, hypertrophic cardiomyopathy (HCM) with midventricular obstruction is often associated with severe symptoms and complications. None of the existing HCM animal models display this particular phenotype. Our group developed a mouse line that overexpresses the ErbB2 receptor (ErbB2(tg)) in cardiomyocytes; we previously showed that the ErbB2 receptor induces cardiomyocyte hypertrophy, myocyte disarray, and fibrosis compatible with HCM. In the current study, we sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of HCM...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27515143/water-safety-and-legionella-in-health-care-priorities-policy-and-practice
#11
REVIEW
Shantini D Gamage, Meredith Ambrose, Stephen M Kralovic, Gary A Roselle
Health care facility water distribution systems have been implicated in the transmission of pathogens such as Legionella and nontuberculous mycobacteria to building occupants. These pathogens are natural inhabitants of water at low numbers and can amplify in premise plumbing water, especially if conditions are conducive to their growth. Because patients and residents in health care facilities are often at heightened risk for opportunistic infections, a multidisciplinary proactive approach to water safety is important to balance the various water priorities in health care and prevent water-associated infections in building occupants...
September 2016: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/27507471/anthocyanins-degradation-during-storage-of-hibiscus-sabdariffa-extract-and-evolution-of-its-degradation-products
#12
André Sinela, Nadirah Rawat, Christian Mertz, Nawel Achir, Hélène Fulcrand, Manuel Dornier
Degradation parameters of two main anthocyanins from roselle extract (Hibiscus sabdariffa L.) stored at different temperatures (4-37°C) over 60days were determined. Anthocyanins and some of their degradation products were monitored and quantified using HPLC-MS and DAD. Degradation of anthocyanins followed first-order kinetics and reaction rate constants (k values), which were obtained by non-linear regression, showed that the degradation rate of delphinidin 3-O-sambubioside was higher than that of cyanidin 3-O-sambubioside with k values of 9...
January 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27447659/the-relation-of-moderate-alcohol-consumption-to-hyperuricemia-in-a-rural-general-population
#13
Zhao Li, Xiaofan Guo, Yamin Liu, Ye Chang, Yingxian Sun, Guangshuo Zhu, Maria Roselle Abraham
BACKGROUND: although alcohol abuse is known to increase serum uric acid, the relation between moderate drinking and uric acid have remained poorly understood. We performed this study to evaluate whether different alcohol consumption level has different effects on the risk of hyperuricemia based on a rural general population. METHOD: multi-stage cluster sampling method was used to select a representative sample of individuals aged 35 years or older. Participants were asked to provide information about their alcohol consumption...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27444805/anthocyanins-from-roselle-extract-arrest-cell-cycle-g2-m-phase-transition-via-atm-chk-pathway-in-p53-deficient-leukemia-hl-60-cells
#14
Tsung-Chang Tsai, Hui-Pei Huang, Kai-Ting Chang, Chau-Jong Wang, Yun-Ching Chang
Cell cycle regulation is an important issue in cancer therapy. Delphinidin and cyanidin are two major anthocyanins of the roselle plant (Hibiscus sabdariffa). In the present study, we investigated the effect of Hibiscus anthocyanins (HAs) on cell cycle arrest in human leukemia cell line HL-60 and the analyzed the underlying molecular mechanisms. HAs extracted from roselle calyces (purity 90%) markedly induced G2/M arrest evaluated with flow cytometry analysis. Western blot analyses revealed that HAs (0.1-0...
July 22, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27433731/fabrication-of-natural-sensitizer-extracted-from-mixture-of-purple-cabbage-roselle-wormwood-and-seaweed-with-high-conversion-efficiency-for-dssc
#15
Ho Chang, Xuan-Rong Lai
This study aims to deal with the influence of different solvent in extraction of natural sensitizer and different thickness of photoelectrode thin film on the photoelectric conversion efficiency and the electron transport properties for the prepared dye-sensitized solar cells (DSSC). The natural dyes of anthocyanin and chlorophyll dyes are extracted from mixture of purple cabbage and roselle and mixture of wormwood and seaweed, respectively. The experimental results show the cocktail dye extracted with ethanol and rotating speed of spin coating at 1000 rpm can achieve the greatest photoelectric conversion efficiency up to 1...
February 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27402292/roselle-polyphenols-exert-potent-negative-inotropic-effects-via-modulation-of-intracellular-calcium-regulatory-channels-in-isolated-rat-heart
#16
Yi-Cheng Lim, Siti Balkis Budin, Faizah Othman, Jalifah Latip, Satirah Zainalabidin
Roselle (Hibiscus sabdariffa Linn.) calyces have demonstrated propitious cardioprotective effects in animal and clinical studies; however, little is known about its action on cardiac mechanical function. This study was undertaken to investigate direct action of roselle polyphenols (RP) on cardiac function in Langendorff-perfused rat hearts. We utilized RP extract which consists of 12 flavonoids and seven phenolic acids (as shown by HPLC profiling) and has a safe concentration range between 125 and 500 μg/ml in this study...
July 11, 2016: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/27358355/the-effect-of-a-nationwide-infection-control-program-expansion-on-hospital-onset-gram-negative-rod-bacteremia-in-130-veterans-health-administration-medical-centers-an-interrupted-time-series-analysis
#17
Michihiko Goto, Amy M J O'Shea, Daniel J Livorsi, Jennifer S McDanel, Makoto M Jones, Kelly K Richardson, Brice F Beck, Bruce Alexander, Martin E Evans, Gary A Roselle, Stephen M Kralovic, Eli N Perencevich
BACKGROUND: The Veterans Health Administration (VHA) introduced the Methicillin-Resistant Staphylococcus aureus (MRSA) Prevention Initiative in March 2007. Although the initiative has been perceived as a vertical intervention focusing on MRSA, it also expanded infection prevention and control programs and resources. We aimed to assess the horizontal effect of the initiative on hospital-onset (HO) gram-negative rod (GNR) bacteremia. METHODS: This retrospective cohort included all patients who had HO bacteremia due to Escherichia coli, Klebsiella species, or Pseudomonas aeruginosa at 130 VHA facilities from January 2003 to December 2013...
September 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27314462/reduction-of-dilution-error-in-elisas-using-an-internal-standard
#18
Thorsten Verch, Christopher Roselle, Mary Shank-Retzlaff
BACKGROUND: Dilution bias is a major cause of immunoassay variability due to the lack of an internal standard to determine the true versus the expected dilution value. METHODOLOGY: We used an internal control to measure dilution bias in an ELISA. Acridine-orange was added at the first dilution step and monitored throughout dilutions. Assay results were corrected using the fluorescent signal ratio between samples and reference. Acridine dilution correlated with analyte-specific assay measurements (R2 = 0...
July 2016: Bioanalysis
https://www.readbyqxmd.com/read/27227945/the-association-between-alcohol-consumption-and-left-ventricular-ejection-fraction-an-observational-study-on-a-general-population
#19
Zhao Li, Xiaofan Guo, Yinglong Bai, Guozhe Sun, Yufan Guan, Yingxian Sun, Abraham Maria Roselle
The results of previous studies on the relation between alcohol consumption and heart failure (HF) have been inconsistent. This study aimed to evaluate the association between alcohol consumption and left ventricular ejection fraction (LVEF) in a general population.A total of 10,824 adults were examined using a multistage cluster sampling method to select a representative sample of individuals who were at least 35-years old. The participants were asked to provide information about their alcohol consumption...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27226105/hibiscus-sabdariffa-roselle-extracts-and-wine-phytochemical-profile-physicochemical-properties-and-carbohydrase-inhibition
#20
Idolo Ifie, Lisa J Marshall, Peter Ho, Gary Williamson
Three varieties of Hibiscus sabdariffa were analyzed for their phytochemical content and inhibitory potential on carbohydrate-digesting enzymes as a basis for selecting a variety for wine production. The dark red variety was chosen as it was highest in phenolic content and an aqueous extract partially inhibited α-glucosidase (maltase), with delphinidin 3-O-sambubioside, cyanidin 3-O-sambubioside, and 3-O-caffeoylquinic acid accounting for 65% of this activity. None of the varieties significantly inhibited α-amylase...
June 22, 2016: Journal of Agricultural and Food Chemistry
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