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https://www.readbyqxmd.com/read/27855070/pharmacokinetics-of-the-first-line-antituberculosis-drugs-in-ghanaian-children-with-tuberculosis-with-and-without-hiv-coinfection
#1
Sampson Antwi, Hongmei Yang, Anthony Enimil, Anima M Sarfo, Fizza S Gillani, Daniel Ansong, Albert Dompreh, Antoinette Orstin, Theresa Opoku, Dennis Bosumtwe, Lubbe Wiesner, Jennifer Norman, Charles A Peloquin, Awewura Kwara
Although human immunodefiency virus (HIV) coinfection is the most important risk factor for poor antituberculosis (anti-TB) treatment response, its effect on the pharmacokinetics of the first-line drugs in children is understudied. This study examined the pharmacokinetics of the four first-line anti-TB drugs in children with tuberculosis (TB) with and without HIV coinfection. Ghanaian children with TB on isoniazid, rifampin, pyrazinamide and ethambutol for at least 4 weeks had blood samples collected at pre-dose, 1, 2, 4, and 8-hours post-dose...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26016044/-occupational-exposure-to-biological-agents-intentionally-used-in-polish-enterprises
#2
Anna Kozajda, Irena Szadkowska-Stańczyk
BACKGROUND: The paper presents the intentional use of biological agents for industrial, diagnostic and research purposes in Polish enterprises. MATERIAL AND METHODS: The National Register of Biological Agents (Krajowy Rejestr Czynników Biologicznych - KRCB) is an online database that collects the data on the intentional use of biological agents at work in Poland. RESULTS: As of December 2013 there were 533 notifications in KRCB, mainly for diagnostic (73%), research (20%) and industrial purposes (7%)...
2015: Medycyna Pracy
https://www.readbyqxmd.com/read/25916018/screening-for-diabetes-mellitus-and-human-immunodefiency-virus-infection-in-persons-with-tuberculosis
#3
A O Ogbera, A Kapur, K Odeyemi, K Longe-Peters, O O Adeyeye, I Odeniyi, B E Ogunnowo
INTRODUCTION: Nigeria is a country saddled with a high tuberculosis (TB) and human immunodeficiency virus (HIV) burden but the possible combination of these communicable diseases with diabetes mellitus (DM) has been overlooked. We undertook to determine the burden of HIV and DM in persons with TB by documenting the prevalence rates of these disorders. METHODS: This is a cross-sectional Study that was conducted within 54TB/DOT centers in Lagos State. A total of 3,376 persons with TB who were on antiTB drugs were screened for HIV and DM using standardized tests...
June 2014: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/25337749/high-dose-rifapentine-with-moxifloxacin-for-pulmonary-tuberculosis
#4
RANDOMIZED CONTROLLED TRIAL
Amina Jindani, Thomas S Harrison, Andrew J Nunn, Patrick P J Phillips, Gavin J Churchyard, Salome Charalambous, Mark Hatherill, Hennie Geldenhuys, Helen M McIlleron, Simbarashe P Zvada, Stanley Mungofa, Nasir A Shah, Simukai Zizhou, Lloyd Magweta, James Shepherd, Sambayawo Nyirenda, Janneke H van Dijk, Heather E Clouting, David Coleman, Anna L E Bateson, Timothy D McHugh, Philip D Butcher, Denny A Mitchison
BACKGROUND: Tuberculosis regimens that are shorter and simpler than the current 6-month daily regimen are needed. METHODS: We randomly assigned patients with newly diagnosed, smear-positive, drug-sensitive tuberculosis to one of three regimens: a control regimen that included 2 months of ethambutol, isoniazid, rifampicin, and pyrazinamide administered daily followed by 4 months of daily isoniazid and rifampicin; a 4-month regimen in which the isoniazid in the control regimen was replaced by moxifloxacin administered daily for 2 months followed by moxifloxacin and 900 mg of rifapentine administered twice weekly for 2 months; or a 6-month regimen in which isoniazid was replaced by daily moxifloxacin for 2 months followed by one weekly dose of both moxifloxacin and 1200 mg of rifapentine for 4 months...
October 23, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24401677/refractory-invasive-aspergillosis-controlled-with-posaconazole-and-pulmonary-surgery-in-a-patient-with-chronic-granulomatous-disease-case-report
#5
Eda Kepenekli, Ahmet Soysal, Canan Kuzdan, Nezih Onur Ermerak, Mustafa Yüksel, Mustafa Bakır
Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Among primary immunodefiencies, chronic granulomatous disease (CGD) has the highest prevalence of invasive fungal diseases. Voriconazole is recommended for the primary treatment of invasive aspergillosis in most patients. In patients whose aspergillosis is refractory to voriconazole, therapeutic options include changing class of antifungal, for example using an amphotericin B formulation, an echinocandin, combination therapy, or further use of azoles...
2014: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/24381619/comparative-study-of-smear-microscopy-rapid-slide-culture-and-lowenstein-jensen-culture-in-cases-of-pulmonary-tuberculosis-in-a-tertiary-care-hospital
#6
Ravish Kumar Muddaiah, Pratibha Malini James, Ravikumar Kadahalli Lingegowda
BACKGROUND: Tuberculosis (TB), a dreadful disease known to mankind continues to be a problem in a developing country like India. The incidence of people getting infected with TB is on the rise due to compounding factors like coinfection with the human immunodefiency virus and multidrug-resistant strains. There is a definitive need for early diagnosis and treatment of TB to curb transmission of the infection. Direct smear microscopy, though cheap and rapid, lacks sensitivity. Isolation of Mycobacterium tuberculosis in culture requires a long time, because of which there is a need for a rapid method which has good sensitivity and specificity for the detection of M...
September 2013: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/23303117/human-immunodeficiency-virus-hiv-in-pregnancy-a-review-of-the-guidelines-for-preventing-mother-to-child-transmission-in-malaysia
#7
REVIEW
Iskandar Azwa, Su Yen Khong
Mother-to-child transmission (MTCT) of human immunodefi ciency virus (HIV) is a devastating consequence of HIV infection during pregnancy and is largely preventable. Evidence-based interventions such as universal antenatal screening, provision of antiretroviral therapy, delivery by elective caesarean section and avoidance of breastfeeding have ensured that the rates of MTCT remain low in Malaysia. This review discusses the most recent advances in the management of HIV infection in pregnancy with emphasis on antiretroviral treatment strategies and obstetric care in a middle income country...
December 2012: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/23303113/causes-of-death-and-factors-associated-with-early-death-among-human-immunodeficiency-virus-hiv-infected-persons-in-singapore-pre-highly-active-antiretroviral-therapy-haart-and-peri-haart
#8
Angela Chow, Jeannie Tey, Mar Kyaw Win, Yee Sin Leo
INTRODUCTION: Highly active antiretroviral therapy (HAART) has greatly changed the epidemiology of human immunodefi ciency virus (HIV) mortality. The aim of this study is to compare the causes of death and factors associated with early death in HIV-infected persons in the pre- and peri-highly active antiretroviral therapy (HAART) periods. MATERIALS AND METHODS: We conducted a retrospective review of 483 HIV-infected persons who were diagnosed with HIV from 1985 to 2000, and had died within 5 years of the diagnosis...
December 2012: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/23067008/ascorbic-acid-kills-epstein-barr-virus-positive-burkitt-lymphoma-cells-and-epstein-barr-virus-transformed-b-cells-in-vitro-but-not-in-vivo
#9
Amber N Shatzer, Michael Graham Espey, Mayra Chavez, Hongbin Tu, Mark Levine, Jeffrey I Cohen
Ascorbic acid has been shown to kill various cancer cell lines at pharmacologic concentrations. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were more susceptible to ascorbic acid-induced cell killing than EBV-negative BL cells or EBV-transformed lymphoblastoid cells (LCLs). Ascorbic acid did not induce apoptosis in any of the tested cells but did induce the production of reactive oxygen species and cell death. Previously, we showed that bortezomib, a proteasome inhibitor, induces cell death in LCLs and EBV-positive BL cells...
May 2013: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/22923890/oral-manifestations-of-human-immunodeficiency-virus-in-children-an-institutional-study-at-highly-active-antiretroviral-therapy-centre-in-india
#10
Srinivas Rao Ponnam, Gautam Srivastava, Kotaih Theruru
CONTEXT: More than 1000 children are newly infected with Human immunodefi ciency virus (HIV) every day, and of these more than half will die as a result of AIDS due to lack of access to HIV treatment. HIV disease varies considerably in children. Among those infected prenatally, some experience few or no symptoms for years, whereas in others the disease progresses rapidly. The risk factors that influence the development of such oral manifestations include, low CD4+ T cell count, xerostomia and lack of highly active antiretroviral therapy (HAART)...
May 2012: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/22346385/external-quality-assessment-of-transporting-infectious-substances-in-canada
#11
S M Tiffin, M A Noble
OBJECTIVE: To determine the degree of compliance with Transport Canada's Transportation of Dangerous Goods Regulations for transporting infectious substances in Canada. DESIGN: A three-phase study including observation of packages arriving at the British Columbia Centre for Disease Control (BCCDC) provincial laboratory; observation of requested samples of either an Escherichia coli culture or serum, not human immunodeficiency virus (HIV) or HbsAg positive, from laboratories; and a questionnaire concerning training and certification of packers in laboratories...
May 1999: Canadian Journal of Infectious Diseases, Journal Canadien des Maladies Infectieuses
https://www.readbyqxmd.com/read/21913525/genotyping-of-human-immunodefiency-virus-isolates-in-papua-new-guinea
#12
C E Anyiwo, M Imai, J D Igo, Bo Ogunbanjo, A Iwamoto, D V Babona
BACKGROUND: There has been considerable escalation in the incidence of HIV infection in Papua New Guinea since the first cases have been reported in 1987. OBJECTIVES: The study was to identify the genetic subtype in HIV infected patients in Papua New Guinea. It is believed that the result will not only assist in tracing and tracking the sources of the infection, but will also help to evaluate the impact of the genotypes on the natural history of HIV in Papua New Guinea...
October 2010: Nigerian Quarterly Journal of Hospital Medicine
https://www.readbyqxmd.com/read/21625568/siv-nef-proteins-recruit-the-ap-2-complex-to-antagonize-tetherin-and-facilitate-virion-release
#13
Fengwen Zhang, Wilmina N Landford, Melinda Ng, Matthew W McNatt, Paul D Bieniasz, Theodora Hatziioannou
Lentiviral Nef proteins have multiple functions and are important for viral pathogenesis. Recently, Nef proteins from many simian immunodefiency viruses were shown to antagonize a cellular antiviral protein, named Tetherin, that blocks release of viral particles from the cell surface. However, the mechanism by which Nef antagonizes Tetherin is unknown. Here, using related Nef proteins that differ in their ability to antagonize Tetherin, we identify three amino-acids in the C-terminal domain of Nef that are critical specifically for its ability to antagonize Tetherin...
May 2011: PLoS Pathogens
https://www.readbyqxmd.com/read/20396657/tuberculosis-of-spleen-presenting-with-pyrexia-of-unknown-origin-in-a-non-immunocompromised-woman
#14
Prem Parkash Gupta, Sanjay Fotedar, Dipti Agarwal, Pradeep Sansanwal
Splenic lesions due to tuberculosis are extremely rare in immunocompetent indi-viduals and delays in diagnosis are frequent. Here, we describe a 49-year-woman presenting with pyrexia-of-unknown origin with no evidence of any immunodefi-ciency. Computed tomography of the abdomen showed an enlarged spleen having multiple small focal hypodense lesions; the later were confirmed to be of tubercu-lous etiology on histopathological examination. She had favorable response with anti-tubercular chemotherapy. We report this case of tuberculosis spleen in an im-munocompetent individual for its rarity and to highlight the fact that these patients can be managed by medical treatment effectively...
January 2008: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/20364539/seroprevalence-and-correlates-of-hiv-and-hcv-among-injecting-drug-users-in-edmonton-alberta
#15
Sabrina S Plitt, Jennifer Gratrix, Sharyn Hewitt, Patsy Conroy, Tracy Parnell, Beverly Lucki, Vicki Pilling, Barbara Anderson, Yogesh Choudri, Chris P Archibald, Ameeta E Singh
BACKGROUND: Injection drug users (IDUs) are at risk for acquiring human immunodefiency virus (HIV) and hepatitis C virus (HCV) via parenteral and sexual transmission. We determined the seroprevalence and correlates of HIV and HCV for IDUs recruited in Edmonton, Alberta. METHODS: Edmonton was one site of a multi-site, national survey (I-Track Study). From April to June 2005, IDUs were recruited and administered a questionnaire collecting information on demographics, drug use, sexual behaviours, and HIV/HCV testing behaviours...
January 2010: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/20095034/bone-marrow-biopsy-in-patients-with-hepatitis-c-virus-infection-spectrum-of-findings-and-diagnostic-utility
#16
Jeffery M Klco, Bob Geng, Elizabeth M Brunt, Anjum Hassan, Tu-Dung Nguyen, Friederike H Kreisel, Mauricio Lisker-Melman, John L Frater
Patients with hepatitis C virus (HCV) infection develop a number of hematologic disorders, with benign and malignant B-cell proliferations being the most common. HCV-infected patients are also prone to developing peripheral cytopenias, the etiologies of which are multifactorial and include hypersplenism and/or antiviral medications. Some of these patients may undergo bone marrow biopsy but no study has systematically recorded the bone marrow findings in this patient group. Here, we report on the range of bone marrow findings in 47 adult HCV-infected patients...
February 2010: American Journal of Hematology
https://www.readbyqxmd.com/read/19915684/hiv-1-integrase-strand-transfer-inhibitors-novel-insights-into-their-mechanism-of-action
#17
Krishan K Pandey, Duane P Grandgenett
Human immunodefi ciency virus type-1 integrase (IN) is a new and novel target for inhibitors. Strand transfer inhibitors effectively prevent concerted integration of viral DNA by IN into the host chromosomes. Raltegravir is the fi rst approved strand transfer inhibitor for the treatment of HIV-1/AIDS. We propose a mechanistic hypothesis as to "when and where" these inhibitors are active in virus-infected cells. Using native agarose gel electrophoresis, we identified a transient synaptic complex (SC) wherein IN non-covalently juxtaposes two viral DNA ends...
November 5, 2008: Retrovirology: Research and Treatment
https://www.readbyqxmd.com/read/19478276/high-early-mortality-in-patients-with-chronic-acquired-immunodeficiency-syndrome-diarrhea-initiating-antiretroviral-therapy-in-haiti-a-case-control-study
#18
Rebecca A Dillingham, Relana Pinkerton, Paul Leger, Patrice Severe, Richard L Guerrant, J William Pape, Daniel W Fitzgerald
This case-control study examines whether chronic diarrhea at initiation of antiretroviral therapy (ART) affects survival of human immunodefiency virus-infected patients. Cases (288) were treatment-naive, non-pregnant, adults with self report of frequent loose stool for > 3 weeks at the time ART was initiated. One-third of patients had an enteric pathogen identified including Cryptosporidium spp., Giardia spp., Isospora belli, Cyclospora cayetanensis, and Entamoeba histolytica. Control patients (400) did not have diarrhea when initiating ART...
June 2009: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/19220361/drug-resistant-human-immunodefiency-virus
#19
REVIEW
M J Kozal
The development of antiretroviral therapy has led to a major reduction in human immunodeficiency virus (HIV)-related mortality. There are now six antiretroviral drug classes, with more than 20 unique antiretroviral drugs. However, HIV drug resistance occurs with all antiretroviral agents. Drug resistance can affect the response to antiretroviral therapy and is associated with increased mortality. The emergence of resistance in persons on antiretroviral therapy and the transmission of drug-resistant HIV strains to newly infected persons are now major public health concerns...
January 2009: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/18581025/occupational-exposure-to-body-fluids-among-healthcare-workers-a-report-from-iran
#20
A Hadadi, S Afhami, M Karbakhsh, N Esmailpour
INTRODUCTION: Healthcare workers (HCWs) are at substantial risk of acquiring blood-borne infections through contact with body fluids of patients. The main objectives of this study were to determine the epidemiological characteristics and risk factors of the occupational exposures to body fluids. METHODS: This cross-sectional study was conducted from December 2004 to June 2005 among HCWs from three University hospitals in Tehran, Iran, who had the potential for high risk exposures during the year preceding the study...
June 2008: Singapore Medical Journal
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