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JOURNAL ARTICLE
Stanley Kalata, Jyothi R Thumma, Kyle H Sheetz
No abstract text is available yet for this article.
February 28, 2024: JAMA Surgery
#22
JOURNAL ARTICLE
Eugene O Dickens
No abstract text is available yet for this article.
February 28, 2024: JAMA Surgery
#23
JOURNAL ARTICLE
M Dogan Unlu, D Uysal, N F Karakuyu, S Asci, O Ozmen, M Y Tepebasi
PURPOSE: The ischemia-reperfusion (I/R) injury seen in the heart can cause severe damage to essential organs such as the brain. Cannabidiol (CBD) obtained from Cannabis sativa is used today to treat various diseases. This study aimed to demonstrate CBD's neuroprotective and therapeutic properties in rats with brain damage caused by I/R in the heart. MATERIALS: Rats were divided into four groups; sham, I/R, I/R + Prophylactic CBD, and I/R + Therapeutic CBD...
February 22, 2024: Neuroscience Letters
#24
JOURNAL ARTICLE
Ozlem Ozmen, Adem Milletsever, Serife Tasan, Esma Selcuk, Mehtap Savran
Methotrexate (MTX) is a widely used medication for various cancers, yet its use is associated with adverse effects on organs, notably the lungs. Cannabidiol (CBD), known for its antioxidant and anti-inflammatory properties, was investigated for its potential protective effects against MTX-induced lung injury. Thirty-two female Wistar Albino rats were divided into four groups: control, MTX (single 20 mg/kg intraperitoneal dose), MTX + CBD (single 20 mg/kg MTX with 0.1 ml of 5 mg/kg CBD for 7 days intraperitoneally) and CBD only (for 7 days)...
February 22, 2024: Basic & Clinical Pharmacology & Toxicology
#25
JOURNAL ARTICLE
Love Garg, Arun Vaidya, Aditya Kale, Amrit Gopan, Abu Ansari, Biswa Ranjan Patra, Akash Shukla
INTRODUCTION: There is sparse data from India on indications, technical success, safety and outcomes of endoscopic retrograde cholangiopancreatography (ERCP) using standard adult duodenoscope in the pediatric population. METHODS: Retrospective analysis of prospectively maintained electronic endoscopy and clinical database was performed to identify pediatric patients (age ≤ 18 years) who underwent ERCP between January 2017 and December 2022...
February 17, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#26
Qiu Ming, Yang Jun, Luo Nai-Wen, Cao Lei, Fan Yu-Dong, Wang Shu-Guang
The formation of an internal fistula between the biliary system and the gastrointestinal tract is a rare condition with various etiologies, predominantly associated with recurrent chronic inflammation of the biliary system and tumors. Patients with this condition may lack specific clinical manifestations, presenting with symptoms such as abdominal pain, fever, jaundice, or may show no clinical signs at all. Common types of internal fistulas include cholecystoduodenal fistula, cholecystocolonic fistula, and choledochoduodenal fistula...
2024: Frontiers in Medicine
#27
JOURNAL ARTICLE
Geoffrey Yuet Mun Wong, Himanshu Wadhawan, Victor Roth Cardoso, Laura Bravo Merodio, Yashasvi Rajeev, Ricardo David Maldonado, Alessandro Martinino, Vignesh Balasubaramaniam, Aabid Ashraf, Adeela Siddiqui, Ahmad Ghassan Al-Shkirat, Ahmed Mohammed Abu-Elfatth, Ajay Gupta, Akram Alkaseek, Amel Ouyahia, Amira Said, Anshuman Pandey, Ashwani Kumar, Baila Maqbool, Carlos Alberto Millán, Cheena Singh, Diana Alejandra Pantoja Pachajoa, Dmitry Mikhailovich Adamovich, Enrique Petracchi, Fariha Ashraf, Marco Clementi, Francesk Mulita, Gad Amram Marom, Gamaleldeen Abdulaal, Georgios-Ioannis Verras, Giacomo Calini, Gianluigi Moretto, Hossam Elfeki, Hui Liang, Humam Jalaawiy, Ibrahim Elzayat, Jayanta Kumar Das, Jose Miguel Aceves-Ayala, Kazi Taslima Ahmed, Luca Degrate, Manisha Aggarwal, Mohammed Ahmed Omar, Mounira Rais, Muhammed Elhadi, Nasser Sakran, Rajesh Bhojwani, Ramesh Agarwalla, Samir Kanaan, Sarnai Erdene, Serge Chooklin, Suhail Khuroo, Surrendar Dawani, Syed Tanseer Asghar, Tak Kwan James Fung, Taryel Omarov, Valentin Titus Grigorean, Zdenko Boras, Georgios V Gkoutos, Rishi Singhal, Kamal Mahawar
OBJECTIVE: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications. SUMMARY BACKGROUND DATA: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level. METHODS: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed...
February 13, 2024: Annals of Surgery
#28
Yu Jinnin, Taichiro Tsunoyama, Tsuyoshi Nagao, Keiji Sano, Kaori Ito
No abstract text is available yet for this article.
2024: Trauma Surgery & Acute Care Open
#29
JOURNAL ARTICLE
Zhaoping Wu, Yi Zhou, Xianglin Hou, Weidong Liu, Wen Yin, Lei Wang, Yudong Cao, Zhipeng Jiang, Youwei Guo, Quan Chen, Wen Xie, Ziqiang Wang, Ning Shi, Yujun Liu, Xiang Gao, Longlong Luo, Jianwu Dai, Caiping Ren, Xingjun Jiang
Induced pluripotent stem cells (iPSCs) can be personalized and differentiated into neural stem cells (NSCs), thereby effectively providing a source of transplanted cells for spinal cord injury (SCI). To further improve the repair efficiency of SCI, we designed a functional neural network tissue based on TrkC-modified iPSC-derived NSCs and a CBD-NT3-modified linear-ordered collagen scaffold (LOCS). We confirmed that transplantation of this tissue regenerated neurons and synapses, improved the microenvironment of the injured area, enhanced remodeling of the extracellular matrix, and promoted functional recovery of the hind limbs in a rat SCI model with complete transection...
May 2024: Bioactive Materials
#30
JOURNAL ARTICLE
Shirley X Deng, Bree T Sharma, Tega Ebeye, Anas Samman, Amna Zulfiqar, Brittany Greene, Melanie E Tsang, Shiva Jayaraman
BACKGROUND: We have developed an algorithmic approach to laparoscopic cholecystectomy, including subtotal cholecystectomy, as a bailout strategy when the Critical View of Safety cannot be safely achieved due to significant inflammation and fibrosis of the hepatocystic triangle. METHODS: This is a retrospective cohort study comparing postoperative outcomes in patients with severe cholecystitis who underwent laparoscopic cholecystectomy or laparoscopic subtotal cholecystectomy at St...
February 6, 2024: Surgery
#31
Med Dheker Touati, Anis Belhadj, Mohamed Raouf Ben Othmane, Fahd Khefacha, Syrine Khabthani, Ahmed Saidani
INTRODUCTION AND IMPORTANCE: Mirizzi syndrome, a rare complication of cholelithiasis, involves gallstones causing common hepatic duct compression. It poses diagnostic challenges with nonspecific symptoms. Early recognition and surgical intervention are crucial, emphasizing a multidisciplinary approach for this complex condition with potential complications. CASE REPORT: A 69-year-old woman presented with pruritus, jaundice, and a history of hepatic colics. Laboratory results showed no signs of inflammation but indicated cholestasis...
January 26, 2024: International Journal of Surgery Case Reports
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JOURNAL ARTICLE
Michael J Alaia, Zachary I Li, Isabel Chalem, Eoghan T Hurley, Kinjal Vasavada, Guillem Gonzalez-Lomas, Andrew S Rokito, Laith M Jazrawi, Kevin Kaplan
BACKGROUND: Cannabidiol (CBD) has been shown recently to positively affect patient pain and satisfaction immediately after arthroscopic rotator cuff repair (ARCR). However, it is unclear whether the addition of CBD to a perioperative regimen could affect postoperative outcomes. PURPOSE: To evaluate patient-reported outcomes among patients who underwent ARCR and received buccally absorbed CBD or an identical placebo for early postoperative pain management at 1-year follow-up...
February 2024: Orthopaedic Journal of Sports Medicine
#33
EDITORIAL
Jorge Quarleri, M Victoria Delpino
In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily targets the respiratory system, but evidence suggests extrapulmonary organ involvement, notably in the liver. Viral RNA has been detected in hepatic tissues, and in situ hybridization revealed virions in blood vessels and endothelial cells. Electron microscopy confirmed viral particles in hepatocytes, emphasizing the need for understanding hepatotropism and direct cytopathic effects in COVID-19-related liver injury...
January 27, 2024: World Journal of Hepatology
#34
JOURNAL ARTICLE
Genevieve R Mazza, Ariane C Youssefzadeh, Laurel S Aberle, Zachary S Anderson, Rachel S Mandelbaum, Joseph G Ouzounian, Kazuhide Matsushima, Koji Matsuo
BACKGROUND: Gallstone disease in pregnancy is one of the most common indications for nonobstetrical surgery during pregnancy. National-level data on contemporary surgical practice and outcomes are limited. OBJECTIVE: This study aimed to assess the clinical characteristics and outcomes of patients undergoing cholecystectomy during pregnancy. STUDY DESIGN: This cross-sectional study examined the Healthcare Cost and Utilization Project's 2 nationwide databases in the United States: the National Inpatient Sample and the Nationwide Ambulatory Surgery Sample...
February 2024: AJOG global reports
#35
JOURNAL ARTICLE
Aarón Del Pozo, María de Hoz-Rivera, Angela Romero, María Villa, María Martínez, Laura Silva, Fabiana Piscitelli, Vincenzo Di Marzo, Ana Gutiérrez-Rodríguez, William Hind, José Martínez-Orgado
Intraventricular hemorrhage (IVH) is an important cause of long-term disability in extremely preterm infants, with no current treatment. This study assessed the potential neuroprotective effects of cannabidiol (CBD) in an IVH model using immature rats. IVH was induced in 1-day-old (P1) Wistar rats by left periventricular injection of Clostridial collagenase. Some rats received CBD prenatally (10 mg/kg i.p. to the dam) and then 5 mg/kg i.p. 6, 30 and 54 h after IVH (IVH+CBD, n = 30)...
January 31, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
#36
JOURNAL ARTICLE
Jessica L Beers, Zhu Zhou, Klarissa D Jackson
Cannabidiol (CBD) is a pharmacologically active metabolite of cannabis that is FDA-approved to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex in children aged one year and older. During clinical trials, CBD caused dose-dependent hepatocellular toxicity at therapeutic doses. The risk for toxicity was increased in patients taking valproate (VPA), another hepatotoxic antiepileptic drug, through an unknown mechanism. With the growing popularity of CBD in the consumer market, an improved understanding of the safety risks associated with CBD is needed to ensure public health...
January 29, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
#37
REVIEW
Bakhtawar Awan, Mohamed Elsaigh, Mohamed Marzouk, Azka Sohail, Beshoy Effat Elkomos, Ahmad Asqalan, Safa O Baqar, Noha Elgndy, Omnia Saleh, Justyna Szul, Anna San Juan, Mohamed Alasmar
We aim to investigate the potential of laparoscopic ultrasonography (LUS) as a replacement for intraoperative cholangiography (IOC) in the context of laparoscopic cholecystectomy focusing on various aspects related to both techniques. We made our search through PubMed, Web of Science, Cochrane Library, and Scopus, with the use of the following search strategy: ("laparoscopic ultrasonography" OR LUS OR "laparoscopic US" OR "laparoscopic ultrasound") AND ("laparoscopic cholecystectomy" OR LC). We incorporated diverse studies that addressed our topic, offering data on the identification of biliary anatomy and variations, the utilization of laparoscopic ultrasound in cholecystitis, the detection of common bile duct stones, and the criteria utilized to assess the accuracy of LUS...
December 2023: Curēus
#38
REVIEW
Jonathan G A Koo, Hui Yu Tham, En Qi Toh, Christopher Chia, Amy Thien, Vishal G Shelat
Mirizzi syndrome is a complication of gallstone disease caused by an impacted gallstone in the infundibulum of the gallbladder or within the cystic duct, causing chronic inflammation and extrinsic compression of the common hepatic duct or common bile duct. Eventually, mucosal ulceration occurs and progresses to cholecystobiliary fistulation. Numerous systems exist to classify Mirizzi syndrome, with the Csendes classification widely adopted. It describes five types of Mirizzi syndrome according to the presence of a cholecystobiliary fistula and its corresponding severity, and whether a cholecystoenteric fistula is present...
December 21, 2023: Medicina
#39
JOURNAL ARTICLE
Jennifer Ledezma Dominguez, Noor Tariq, Russell Seth Martins, Ghassan Jawad, Andrew D Fisher, Baila Maqbool
INTRODUCTION: Inflammation in acute cholecystitis may cause a cholecystectomy to be more challenging. Due to the difficult dissection, conversion to subtotal cholecystectomy via laparoscopic or open procedure may be required. This is done to reduce the risk of bile duct injury and hemorrhage. We sought to describe the incidence and risk factors, safety, morbidity, and outcomes associated with bailout procedures. METHODS: A single academic center, retrospective review of laparoscopic cholecystectomies that resulted in bailout procedures performed between January 2015 and December 2020...
January 23, 2024: American Surgeon
#40
JOURNAL ARTICLE
Huiling Cao, Lin Chen, Ziyang Zeng, Xianfeng Wu, Yuhao Lei, Wen Jia, Guang Yue, Bin Yi, Yu-Jie Li, Yuan Shi
AIMS: The objective of this study is to examine the impact of inhibiting Sphingosine 1-phosphate receptor 2 (S1PR2) on liver inflammation, fibrogenesis, and changes of gut microbiome in the context of cholestasis-induced conditions. METHODS: The cholestatic liver injury model was developed by common bile duct ligation (CBDL). Sprague-Dawley rats were randomly allocated to three groups, sham operation, CBDL group and JTE-013 treated CBDL group. Biochemical and histological assessments were conducted to investigate the influence of S1PR2 on the modulation of fibrogenic factors and inflammatory infiltration...
2024: PeerJ
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