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https://www.readbyqxmd.com/read/29125965/death-by-self-mutilation-after-oral-cannabis-consumption
#1
Clemence Delteil, Caroline Sastre, Marie-Dominique Piercecchi, Catherine Faget-Agius, Marc Deveaux, Pascal Kintz, Marc-Antoine Devooght, George Leonetti, Christophe Bartoli, Anne-Laure Pélissier-Alicot
Major self-mutilation (amputation, castration, self-inflicted eye injuries) is frequently associated with psychiatric disorders and/or substance abuse. A 35-year-old man presented with behavioral disturbances of sudden onset after oral cannabis consumption and major self-mutilation (attempted amputation of the right arm, self-enucleation of both eyes and impalement) which resulted in death. During the enquiry, four fragments of a substance resembling cannabis resin were seized at the victim's home. Autopsy confirmed that death was related to hemorrhage following the mutilations...
November 2, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29043289/restoration-of-completely-transected-common-bile-duct-continuity-using-single-operator-cholangioscopy
#2
Saad Emhmed Ali, Houssam Mardini, Mohsin Salih, Steven J Krohmer, Wesam M Frandah
Common bile duct (CBD) injury, ranging from a partial tear to a complete transection, is a major surgical complication of cholecystectomy with significant morbidity and mortality. Proper management of these complex injuries depends on the type and extent of injury and time of recognition. Identifying and repairing injuries during cholecystectomy can prevent development of complications, but this only occurs in about one-third of cases. We report a novel technique to reconnect a transected CBD with assistance of single-operator cholangioscopy...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28951654/the-routine-use-of-cholangiography-for-laparoscopic-cholecystectomy-in-the-modern-era
#3
Evangelos S Photi, Ahmed El-Hadi, Stephanie Brown, Leyla Swafe, Sarah Ashford-Wilson, Jennifer Barwell, Imogen Koopmans, Michael P N Lewis
BACKGROUND AND OBJECTIVES: The use of routine versus selective intra-operative cholangiogram (IOC) for laparoscopic cholecystectomy (LC) remains an area of debate. In this study, we investigated the routine use of IOC in a single center, to determine whether it confers a reduced risk of common bile duct (CBD) injury and improved patient outcomes. We also identified several preoperative predictive factors for CBD stone detection on IOC to investigate the feasibility of a predictive model...
July 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28935932/cannabidiol-attenuates-alcohol-induced-liver-steatosis-metabolic-dysregulation-inflammation-and-neutrophil-mediated-injury
#4
Yuping Wang, Partha Mukhopadhyay, Zongxian Cao, Hua Wang, Dechun Feng, György Haskó, Raphael Mechoulam, Bin Gao, Pal Pacher
Cannabidiol (CBD) is a non-psychoactive component of marijuana, which has anti-inflammatory effects. It has also been approved by FDA for various orphan diseases for exploratory trials. Herein, we investigated the effects of CBD on liver injury induced by chronic plus binge alcohol feeding in mice. CBD or vehicle was administered daily throughout the alcohol feeding study. At the conclusion of the feeding protocol, serums samples, livers or isolated neutrophils were utilized for molecular biology, biochemistry and pathology analysis...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930036/role-for-laparoscopy-in-the-management-of-bile-duct-injuries
#5
REVIEW
Vaibhav Gupta, Shiva Jayaraman
Common bile duct (CBD) injury is the most serious complication of laparoscopic cholecystectomy. Recently, laparoscopic techniques have been used in the management of postoperative bile leak and CBD injury; this literature has not been reviewed. We reviewed the literature on CBD injury, the approach to its diagnosis and management, and reports of laparoscopic management techniques. We combined this review with our experience in laparoscopic methods to highlight diagnostic and therapeutic options. Laparoscopic techniques can be used to prevent, diagnose and treat CBD injuries...
September 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28885457/cannabis-constituent-synergy-in-a-mouse-neuropathic-pain-model
#6
Sherelle L Casey, Nicholas Atwal, Christopher W Vaughan
Cannabis and its psychoactive constituent Δ9-tetrahydrocannabinol (THC) have efficacy against neuropathic pain, however, this is hampered by their side effects. It has been suggested that co-administration with another major constituent cannabidiol (CBD) might enhance the analgesic actions of THC and minimise its deleterious side effects. We examined the basis for this phytocannabinoid interaction in a mouse chronic constriction injury (CCI) model of neuropathic pain. Acute systemic administration of THC dose-dependently reduced CCI-induced mechanical and cold allodynia, but also produced motor incoordination, catalepsy, and sedation...
December 2017: Pain
https://www.readbyqxmd.com/read/28883388/retrospective-clinical-study-of-the-effects-of-t-tube-placement-for-bile-duct-stricture
#7
İbrahim Tayfun Şahiner, Murat Kendirci
BACKGROUND T-tube placement in the common bile duct (CBD) is a surgical alternative to bile duct reconstruction in cholecystectomy for cholecysto-choledocholithiasis, or gallstones. The aim of this retrospective clinical study was to investigate the incidence of late complications of T-tube placement. MATERIAL AND METHODS Retrospective review identified 35 patients who had T-tube placement during cholecystectomy. Clinical data were collected on surgical indications, patient demographics, and clinical symptoms...
September 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28872345/intra-cerebral-cannabidiol-infusion-induced-neuroprotection-is-partly-associated-with-the-tnf-%C3%AE-tnfr1-nf-%C3%B0%C2%BAb-pathway-in-transient-focal-cerebral-ischaemia
#8
Sepideh Khaksar, Mohammad Reza Bigdeli
BACKGROUND: Stroke is a neurological disease, which, in addition to high mortality, imposes many financial and mental burdens on families and the society. The main objective of this study was to investigate the effect of cannabidiol (CBD) on one of the major inflammatory pathways in cerebral ischaemia. METHOD: Using stereotaxic surgery, the cannula was implanted into the right lateral ventricle of rats. CBD (50, 100, and 200 ng/rat; i.c.v.) was administrated for five consecutive days...
September 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28840410/characterization-of-common-bile-duct-injury-after-laparoscopic-cholecystectomy-in-a-high-volume-hospital-system
#9
Julia F Kohn, Alexander Trenk, Kristine Kuchta, Brittany Lapin, Woody Denham, John G Linn, Stephen Haggerty, Ray Joehl, Michael B Ujiki
BACKGROUND: Despite the popularity of laparoscopic cholecystectomy, rates of common bile duct injury remain higher than previously observed in open cholecystectomy. This retrospective chart review sought to determine the prevalence of, and risk factors for, biliary injury during laparoscopic cholecystectomy within a high-volume healthcare system. METHODS: 800 of approximately 3000 cases between 2009 and 2015 were randomly selected and retrospectively reviewed. A single reviewer examined all operative notes, thereby including all cases of BDI regardless of ICD code or need for a second procedure...
August 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28761877/basic-fibroblast-growth-factor-anchored-multilayered-mesenchymal-cell-sheets-accelerate-periosteal-bone-formation
#10
Kentaro Uchida, Gen Inoue, Osamu Matsushita, Kyosuke Horikawa, Hiroyuki Sekiguchi, Wataru Saito, Shotaro Takano, Hisako Fujimaki, Masayuki Miyagi, Masashi Takaso
Cell-based regenerative therapy has the potential to repair bone injuries or large defects that are recalcitrant to conventional treatment methods, including drugs and surgery. Here, we developed a multilayered cell-based bone formation system using cells coated with fibronectin-gelatin (FN-G) nanofilms. The multilayered mesenchymal cells (MLMCs) were formed after two days of culture and were shown to express higher levels of BMP-2 and VEGF compared to monolayer cultures of MCs. The MLMCs were used as a graft material in combination with a fusion protein consisting of basic fibroblast growth factor (bFGF), polycystic kidney disease (PKD) domain, and the collagen-binding domain (CBD) of Clostridium histolyticum collagenase...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28726135/increasing-bile-duct-injury-and-decreasing-utilization-of-intraoperative-cholangiogram-and-common-bile-duct-exploration-over-14%C3%A2-years-an-analysis-of-outcomes-in-new-york-state
#11
Maria S Altieri, Jie Yang, Nabeel Obeid, Chencan Zhu, Mark Talamini, Aurora Pryor
INTRODUCTION: During laparoscopic cholecystectomy (LC), common bile duct (CBD) visualization either directly or with cholangiography (IOC) is less routine. Cholangiography can be used to identify and possibly prevent bile duct injury (BDI), which is a dreaded complication of cholecystectomy. The purpose of our study was to evaluate the trend of IOC/CBD exploration and BDI during LC for benign disease. METHODS: A state-wide database (SPARCS) was used to identify all LC for benign biliary non-obstructive and obstructive disease between 2000 and 2014 in the state of New York...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28671689/reconstruction-of-the-mouse-extrahepatic-biliary-tree-using-primary-human-extrahepatic-cholangiocyte-organoids
#12
Fotios Sampaziotis, Alexander W Justin, Olivia C Tysoe, Stephen Sawiak, Edmund M Godfrey, Sara S Upponi, Richard L Gieseck, Miguel Cardoso de Brito, Natalie Lie Berntsen, María J Gómez-Vázquez, Daniel Ortmann, Loukia Yiangou, Alexander Ross, Johannes Bargehr, Alessandro Bertero, Mariëlle C F Zonneveld, Marianne T Pedersen, Matthias Pawlowski, Laura Valestrand, Pedro Madrigal, Nikitas Georgakopoulos, Negar Pirmadjid, Gregor M Skeldon, John Casey, Wenmiao Shu, Paulina M Materek, Kirsten E Snijders, Stephanie E Brown, Casey A Rimland, Ingrid Simonic, Susan E Davies, Kim B Jensen, Matthias Zilbauer, William T H Gelson, Graeme J Alexander, Sanjay Sinha, Nicholas R F Hannan, Thomas A Wynn, Tom H Karlsen, Espen Melum, Athina E Markaki, Kourosh Saeb-Parsy, Ludovic Vallier
The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical reconstruction. Here we report a new method for the isolation and propagation of human cholangiocytes from the extrahepatic biliary tree in the form of extrahepatic cholangiocyte organoids (ECOs) for regenerative medicine applications. The resulting ECOs closely resemble primary cholangiocytes in terms of their transcriptomic profile and functional properties...
August 2017: Nature Medicine
https://www.readbyqxmd.com/read/28669532/intraoperative-cholangiography-during-cholecystectomy-among-hospitalized-medicare-beneficiaries-with-non-neoplastic-biliary-disease
#13
Elizabeth J Lilley, John W Scott, Wei Jiang, Anna Krasnova, Nikhila Raol, Navin Changoor, Ali Salim, Adil H Haider, Joel S Weissman, Eric B Schneider, Zara Cooper
BACKGROUND: Prior studies of Medicare beneficiaries with both neoplastic and non-neoplastic indications for cholecystectomy demonstrated a reduced risk of common bile duct (CBD) injury when intraoperative cholangiography (IOC) was used. We sought to determine the association between IOC and CBD injury during inpatient cholecystectomy for non-neoplastic biliary disease and compare survival among those with or without CBD injury. METHODS: Retrospective study of patients ≥66 who underwent inpatient cholecystectomy (2005-2010) for gallstones, cholecystitis, cholangitis, or gallbladder obstruction...
October 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28644052/a-little-dab-will-do-ya-in-a-case-report-of-neuro-and-cardiotoxicity-following-use-of-cannabis-concentrates
#14
Shannon S Rickner, Dazhe Cao, Kurt Kleinschmidt, Steven Fleming
CONTEXT: The use of marijuana and cannabis concentrates is increasing, especially following decriminalization in several states. Psychosis and cardiotoxicity have been reported following cannabis use; however, myocardial injury from "dabbing" has not yet been reported. We report a case of hyperthermia, tachycardia, hypertension, severe agitation, neuro-, and cardiotoxicity following the use of "dabs" where there is concomitant confirmatory biological and sample testing. CASE DETAILS: A 17-year-old athletic man developed agitation requiring sedation and intubation for safety, with peak systolic blood pressures in the 190s and hyperthermia (to 102 °F)...
November 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28593410/xanthogranulomatous-cholecystitis-is-an-initial-laparoscopic-approach-feasible
#15
Jae Woo Park, Kee-Hwan Kim, Say-June Kim, Sang Kuon Lee
BACKGROUND: Xanthogranulomatous cholecystitis is an inflammatory disease with pathologically distinct characteristics such as accumulation of lipid-laden macrophages, fibrous tissue, and acute and chronic inflammatory cells. It often involves adjacent organs and mimics gallbladder cancer. The purpose of this study was to review the clinical findings of xanthogranulomatous cholecystitis and to determine the appropriate treatment plan. METHODS: We retrospectively analyzed clinical demographics, operation records, and postoperative results of 31 patients with a pathological diagnosis of xanthogranulomatous cholecystitis who underwent surgery between January 2010 and 2015 at two university hospitals...
June 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28479140/cannabidiol-administration-reduces-sublesional-cancellous-bone-loss-in-rats-with-severe-spinal-cord-injury
#16
Dehao Li, Zilin Lin, Qingyi Meng, Kun Wang, Jiajia Wu, Hongda Yan
Patients with spinal cord injury (SCI) undergo severe loss of bone mineral below the level of lesion, and data on available treatment options after SCI is scarce. The aim of this work was to investigate the therapeutic effect of cannabidiol (CBD), a non-psychoactive cannabis, on sublesional bone loss in a rat model of SCI. The adult male rats were exposed to surgical transection of the cord and treated with CBD for consecutive 14 days. It was found that CBD treatment elevated the serum levels of osteocalcin, reduced the serum levels of collagen type I cross-linked C-telopeptide, and enhanced bone mineral density of tibiae and femurs...
May 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28388598/cannabidiol-reduces-lung-injury-induced-by-hypoxic-ischemic-brain-damage-in-newborn-piglets
#17
Luis Arruza, Maria Ruth Pazos, Nagat Mohammed, Natalia Escribano, Hector Lafuente, Martín Santos, Francisco J Alvarez-Díaz, William Hind, Jose Martínez-Orgado
BackgroundBrain hypoxic-ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario.MethodsNewborn piglets received intravenous vehicle, CBD, or CBD+WAY100635 (5-HT1A receptor antagonist) after HI brain damage (carotid flow interruption and FiO2 0.10 for 30 min). Total lung compliance (TLC), oxygenation index (OI), and extravascular lung water content (EVLW) were monitored for 6 h. Histological damage, interleukin (IL)-1β concentration, and oxidative stress were assessed in brain and lung tissue...
July 2017: Pediatric Research
https://www.readbyqxmd.com/read/28370398/tau-aggregates-where-when-why-and-what-consequences
#18
EDITORIAL
M P Frosch
No abstract text is available yet for this article.
August 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28370167/tau-aggregates-where-when-why-and-what-consequences
#19
EDITORIAL
Matthew P Frosch
Neuropathologists have been aware of neurofibrillary tangles for more than a century following their description as part of Alois Alzheimer's initial report. Since those early days, our understanding of the relationship of this particular type of cellular inclusion associated with neurodegeneration has continually broadened. Textbooks, now a partially antiquated concept, commonly list a range of disorders as being associated with tangles -NDASH- including typical neurodegenerative diseases (Alzheimer disease [AD], forms of frontotemporal lobar degenerations [FTLD-tau], progressive supranuclear palsy [PSP], corticobasal degeneration [CBD], primary aged related tauopathy [PART]), secondary degenerative diseases such as chronic traumatic encephalopathy, metabolic disease (Niemann-Pick disease type C) and infections (SSPE)...
March 30, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28220035/case-report-modified-laparoscopic-subtotal-cholecystectomy-an-alternative-approach-to-the-difficult-gallbladder
#20
Michael S Segal, Richard H Huynh, George O Wright
BACKGROUND Laparoscopic cholecystectomy is a commonly performed surgical procedure. In certain situations visualization of the Callot triangle can become difficult due to inflammation, adhesions, and sclerosing of the anatomy. Without being able to obtain the "critical view of safety" (CVS), there is increased risk of damage to vital structures. An alternative approach to the conventional conversion to an open cholecystectomy (OC) would be a laparoscopic subtotal cholecystectomy (LSC). CASE REPORT We present a case of a 56-year-old male patient with acute cholecystitis with a "difficult gallbladder" managed with LSC...
February 21, 2017: American Journal of Case Reports
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