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https://www.readbyqxmd.com/read/27904308/laparoscopic-transcystic-treatment-biliary-calculi-by-laser-lithotripsy
#1
Jun Liu, Lan Jin, Zhongtao Zhang
BACKGROUND AND OBJECTIVES: Laparoscopic transcystic common bile duct exploration (LTCBDE) is a complex procedure requiring expertise in laparoscopic and choledochoscopic skills. The purpose of this study was to investigate the safety and feasibility of treating biliary calculi through laparoscopic transcystic exploration of the CBD via an ultrathin choledochoscope combined with dual-frequency laser lithotripsy. METHODS: From August 2011 through September 2014, 89 patients at our hospital were treated for cholecystolithiasis with biliary calculi...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27889412/cannabidiol-reduces-neuroinflammation-and-promotes-neuroplasticity-and-functional-recovery-after-brain-ischemia
#2
Marco Aurélio Mori, Erika Meyer, Ligia Mendes Soares, Humberto Milani, Francisco Silveira Guimarães, Rúbia Maria Weffort de Oliveira
This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical present in Cannabis sativa, on the cognitive and emotional impairments induced by bilateral common carotid artery occlusion (BCCAO) in mice. Using a multi-tiered behavioral testing battery during 21days, we found that BCCAO mice exhibited long-lasting functional deficits reflected by increase in anxiety-like behavior (day 9), memory impairments (days 12-18) and despair-like behavior (day 21). Short-term CBD 10mg/kg treatment prevented the cognitive and emotional impairments, attenuated hippocampal neurodegeneration and white matter (WM) injury, and reduced glial response that were induced by BCCAO...
November 23, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27856160/anti-excitotoxic-effects-of-cannabidiol-are-partly-mediated-by-enhancement-of-ncx2-and-ncx3-expression-in-animal-model-of-cerebral-ischemia
#3
Sepideh Khaksar, Mohammad Reza Bigdeli
Excitotoxicity and imbalance of sodium and calcium homeostasis trigger pathophysiologic processes in cerebral ischemia which can accelerate neuronal death. Neuroprotective role of cannabidiol (CBD), one of the main non-psychoactive phytocannabinoids of the cannabis plant, has attracted attention of many researchers in the neurodegenerative diseases studies. The present investigation was designed to determine whether cannabidiol can alleviate the severity of ischemic damages and if it is able to exert its anti-excitotoxic effects through sodium and calcium regulation...
November 14, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27832041/investigation-of-liver-dysfunction-who-should-we-test-for-hepatitis-e
#4
Sebastian J Wallace, Glynn W Webb, Richie G Madden, Hugh C Dalton, Joanne Palmer, Richard T Dalton, Adam Pollard, Rhys Martin, Vasilis Panayi, Gwyn Bennett, Richard P Bendall, Harry R Dalton
AIM: Hepatitis E virus (HEV) is endemic in developed countries, but unrecognized infection is common. Many national guidelines now recommend HEV testing in patients with acute hepatitis irrespective of travel history. The biochemical definition of 'hepatitis' that best predicts HEV infection has not been established. This study aimed to determine parameters of liver biochemistry that should prompt testing for acute HEV. METHODS: This was a retrospective study of serial liver function tests (LFTs) in cases of acute HEV (n=74) and three comparator groups: common bile duct stones (CBD, n=87), drug-induced liver injury (DILI, n=69) and patients testing negative for HEV (n=530)...
November 9, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27757083/an-orally-active-cannabis-extract-with-high-content-in-cannabidiol-attenuates-chemically-induced-intestinal-inflammation-and-hypermotility-in-the-mouse
#5
Ester Pagano, Raffaele Capasso, Fabiana Piscitelli, Barbara Romano, Olga A Parisi, Stefania Finizio, Anna Lauritano, Vincenzo Di Marzo, Angelo A Izzo, Francesca Borrelli
Anecdotal and scientific evidence suggests that Cannabis use may be beneficial in inflammatory bowel disease (IBD) patients. Here, we have investigated the effect of a standardized Cannabis sativa extract with high content of cannabidiol (CBD), here named CBD BDS for "CBD botanical drug substance," on mucosal inflammation and hypermotility in mouse models of intestinal inflammation. Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid (DNBS). Motility was evaluated in the experimental model of intestinal hypermotility induced by irritant croton oil...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27733103/acceleration-of-healing-of-traumatic-tympanic-membrane-perforation-in-rats-by-implanted-collagen-membrane-integrated-with-collagen-binding-basic-fibroblast-growth-factor
#6
Qin Shi, Dan Zhang, Zhen Huang, Peng Sun, Haiping Huang, Yunmei Zhang, Jianwu Dai, Jisheng Liu
Traumatic tympanic membrane (TM) perforation is very common in clinical practice. Several biomaterials have been reported to play a role in TM reparation, whereas their functional recovery is limited when used alone. Meanwhile, the administration of bio-factors could promote functional recovery, but rapid distribution and short half-time obstruct their application. In order to study the effect on of traumatic TM regeneration, we prepared collagen membrane (CM) integrated with collagen-binding basic fibroblast growth factor (CBD-bFGF) and implanted into the injury site of perforated TM in Sprague-Dawley (SD) rats...
October 12, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27509535/laparoscopic-common-bile-duct-exploration-versus-open-approach-in-cirrhotic-patients-with-choledocholithiasis-a-retrospective-study
#7
Liang Gui, Ye Liu, Jun Qin, Lei Zheng, Yi-Jun Huang, Yue He, Wen-Sheng Deng, Bin-Bin Qian, Meng Luo
OBJECTIVE: To evaluate the safety and benefits of laparoscopic common bile duct exploration (LCBDE) compared with open approach (OCBDE) in cirrhotic patients. MATERIALS AND METHODS: Between January 2009 and December 2012, a total of 113 cirrhotic patients with choledocholithiasis underwent common bile duct (CBD) explorations in our department. There were two groups of patients: A:LCBDE (n = 61) and B:OCBDE (n = 52). Patients' demographic characteristics, surgical data, postoperative outcomes, and long-term results were retrospectively collected and analyzed...
August 10, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27442189/radially-aligned-electrospun-fibers-with-continuous-gradient-of-sdf1%C3%AE-for-the-guidance-of-neural-stem-cells
#8
Xiaoran Li, Mengyuan Li, Jie Sun, Yan Zhuang, Jiajia Shi, Dongwei Guan, Yanyan Chen, Jianwu Dai
Repair of spinal cord injury will require enhanced recruitment of endogenous neural stem cells (NSCs) from the central canal region to the lesion site to reestablish neural connectivity. The strategy toward this goal is to provide directional cues, e.g., alignment topography and biological gradients from the rostral and caudal ends toward the center. This study demonstrates a facile method for fabrication of continuous gradients of stromal-cell-derived factor-1α (SDF1α) embedded in the radially aligned electrospun collagen/poly (ε-caprolactone) mats...
September 2016: Small
https://www.readbyqxmd.com/read/27418880/abnormal-cannabidiol-attenuates-experimental-colitis-in-mice-promotes-wound-healing-and-inhibits-neutrophil-recruitment
#9
Regina M Krohn, Sean A Parsons, Jakub Fichna, Kamala D Patel, Robin M Yates, Keith A Sharkey, Martin A Storr
BACKGROUND: Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice. METHODS: Colitis was induced in CD1 mice by a single intrarectal administration of trinitrobenzene sulfonic acid (TNBS, 4 mg/100 μl in 30 % ethanol) and Abn-CBD and/or the antagonists O-1918 (Abd-CBD), AM251 (CB1 receptor) and AM630 (CB2 receptor), were administered intraperitoneally (all 5 mg/kg, twice daily for 3 days)...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27411676/elective-laparoscopic-cholecystectomy-without-intraoperative-cholangiography-role-of-preoperative-magnetic-resonance-cholangiopancreatography-a-retrospective-cohort-study
#10
Jinfeng Zang, Yin Yuan, Chi Zhang, Junye Gao
BACKGROUND: Laparoscopic cholecystectomy (LC) is the standard treatment for gallbladder diseases. Intraoperative cholangiography (IOC) can reduce biliary complications of LC; however, with the emergence of magnetic resonance cholangiopancreatography (MRCP), IOC nowadays is faced with unprecedented challenge. The purpose of this study is to evaluate whether preoperative MRCP can safely replace IOC during elective LC in terms of retained common bile duct (CBD) stones and bile duct injury (BDI)...
July 13, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27323575/conversion-of-laparoscopic-cholecystectomy-into-open-cholecystectomy-an-experience-in-300-cases
#11
Tariq Rashid, Asma Naheed, Umar Farooq, Muhammad Iqbal, Najeeb Barkat
BACKGROUND: Laparoscopic cholecystectomy is getting popularity in developing countries especially in Pakistan. Conversion from laparoscopic to open cholecystectomy is also common. This study intends to evaluate the causes of conversion from laparoscopic cholecystectomy to open cholecystectomy and to establish the efficacy and safety of the procedure. METHODS: This descriptive case series was conducted in the department of General Surgery at Social Security Teaching Hospital Islamabad from November 2012 to October 2015...
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/27279403/congenital-absence-of-the-common-bile-duct-a-rare-anomaly-of-extrahepatic-biliary-tract
#12
Tarun Mittal, Mohan V Pulle, Ashish Dey, Vinod K Malik
Congenital absence of the common bile duct (CBD) is an extremely rare developmental anomaly with right and left hepatic ducts draining directly into the gallbladder (GB). Other synonyms for this clinical condition are "cholecystohepatic ducts", "transverse lie of the GB" or "interposition of the GB". The potential for iatrogenic injury is high, because of either inadvertent division or ligation of the ducts. Diagnosis is mostly made intraoperatively, and needs some form of biliary reconstruction. Herein, we are reporting a case of congenital absence of the CBD in a 36-year-old lady that was detected intraoperatively...
July 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27087573/intraoperative-cholangiogram-during-laparoscopic-cholecystectomy-a-clinical-trial-in-rural-setting
#13
Shreya Verma, Matthias W Wichmann, Thomas Gunning, Eben Beukes, Guy Maddern
OBJECTIVE: The routine use of intraoperative cholangiogram (IOC) in laparoscopic cholecystectomy (LC) remains a contentious issue. IOC helps to delineate biliary tree anatomy, prevent bile duct injury and image stones in the common bile duct (CBD). It may prove to be a valuable alternative to ERCP or MRCP, especially in the rural setting with limited resources. DESIGN/SETTING/PARTICIPANTS/INTERVENTIONS/MAIN OUTCOME MEASURES: All patients undergoing laparoscopic cholecystectomy during a 12-month period were audited...
April 17, 2016: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/26887982/the-cannabinoid-quinol-vce-004-8-alleviates-bleomycin-induced-scleroderma-and-exerts-potent-antifibrotic-effects-through-peroxisome-proliferator-activated-receptor-%C3%AE-and-cb2-pathways
#14
Carmen del Río, Carmen Navarrete, Juan A Collado, M Luz Bellido, María Gómez-Cañas, M Ruth Pazos, Javier Fernández-Ruiz, Federica Pollastro, Giovanni Appendino, Marco A Calzado, Irene Cantarero, Eduardo Muñoz
Scleroderma is a group of rare diseases associated with early and transient inflammation and vascular injury, followed by fibrosis affecting the skin and multiple internal organs. Fibroblast activation is the hallmark of scleroderma, and disrupting the intracellular TGFβ signaling may provide a novel approach to controlling fibrosis. Because of its potential role in modulating inflammatory and fibrotic responses, both PPARγ and CB2 receptors represent attractive targets for the development of cannabinoid-based therapies...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26823055/long-term-outcomes-of-patients-with-common-bile-duct-injury-following-laparoscopic-cholecystectomy
#15
Caitlin Halbert, Maria S Altieri, Jie Yang, Ziqi Meng, Hao Chen, Mark Talamini, Aurora Pryor, Purvi Parikh, Dana A Telem
INTRODUCTION: Common bile duct (CBD) injury is a serious and dreaded complication of cholecystectomy. A paucity of data assessing long-term outcomes exists. This study aimed to determine long-term mortality and liver transplantation rates following CBD injury requiring operative intervention. METHODS: Patients were identified via the New York State (NYS) Planning and Research Cooperative System longitudinal administrative database which captures patient-level data from every inpatient and outpatient hospital discharge in NYS...
October 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26772776/cannabidiol-limits-tcell-mediated-chronic-autoimmune-myocarditis-implications-to-autoimmune-disorders-and-organ-transplantation
#16
Wen-Shin Lee, Katalin Erdelyi, Csaba Matyas, Partha Mukhopadhyay, Zoltan V Varga, Lucas Liaudet, György Haskó, Daniela Čiháková, Raphael Mechoulam, Pal Pacher
RATIONALE: Myocarditis is a major cause of heart failure and sudden cardiac death in young adults and adolescents. Many cases of myocarditis are associated with autoimmune processes in which cardiac myosin is a major autoantigen. Conventional immunosuppressive therapies often provide unsatisfactory results and are associated with adverse toxicities during the treatment of autoimmune myocarditis. Cannabidiol (CBD) is a non-psychoactive constituent of Marijuana which exerts antiinflammatory effects independent from classical cannabinoid receptors...
January 8, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/26713772/associations-between-alcohol-outlets-and-emergency-department-injury-presentations-effects-of-distance-from-the-central-business-district
#17
Michelle Hobday, Lynn Meuleners, Wenbin Liang, William Gilmore, Tanya Chikritzhs
OBJECTIVE: To examine the effects of licensed outlets and sales on levels of alcohol-related injuries presenting to emergency departments (EDs) in the Inner, Middle and Outer postcode zones of Perth, Australia. METHODS: Using panel data (2002-2010), a surrogate measure (based on day of week and time of day of presentation) was used to identify alcohol-related injuries presenting at EDs. Postcodes were grouped according to their distance from the central business district (CBD)...
February 2016: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/26593786/functionalized-collagen-scaffold-implantation-and-camp-administration-collectively-facilitate-spinal-cord-regeneration
#18
Xing Li, Jin Han, Yannan Zhao, Wenyong Ding, Jianshu Wei, Jiayin Li, Sufang Han, Xianping Shang, Bin Wang, Bing Chen, Zhifeng Xiao, Jianwu Dai
UNLABELLED: Previous studies have demonstrated that several mechanisms, including numerous inhibitory molecules, weak neurotrophic stimulation and deficient intrinsic regenerative responses, collectively contribute to the failure of mature spinal cord axon regeneration. Thus, combinatorial therapies targeting multiple mechanisms have attracted much attention. In the present study, a porous collagen scaffold was used to support neuronal attachment and bridge axonal regeneration. The scaffold was specifically functionalized using neutralizing proteins (CBD-EphA4LBD, CBD-PlexinB1LBD and NEP1-40) and collagen-binding neurotrophic factors (CBD-BDNF and CBD-NT3) to simultaneously antagonize myelin inhibitory molecules (ephrinB3, Sema4D and Nogo) and exert neurotrophic protection and stimulation...
January 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26540221/anti-inflammatory-effects-of-the-cannabidiol-derivative-dimethylheptyl-cannabidiol-studies-in-bv-2-microglia-and-encephalitogenic-t-cells
#19
Ana Juknat, Ewa Kozela, Nathali Kaushansky, Raphael Mechoulam, Zvi Vogel
BACKGROUND: Dimethylheptyl-cannabidiol (DMH-CBD), a non-psychoactive, synthetic derivative of the phytocannabinoid cannabidiol (CBD), has been reported to be anti-inflammatory in RAW macrophages. Here, we evaluated the effects of DMH-CBD at the transcriptional level in BV-2 microglial cells as well as on the proliferation of encephalitogenic T cells. METHODS: BV-2 cells were pretreated with DMH-CBD, followed by stimulation with the endotoxin lipopolysaccharide (LPS)...
May 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/26510806/presentations-with-alcohol-related-serious-injury-to-a-major-sydney-trauma-hospital-after-2014-changes-to-liquor-laws
#20
Gordian W O Fulde, Myles Smith, S Lesley Forster
OBJECTIVE: To determine any impact associated with changes to liquor licensing regulations on emergency department attendances for alcohol-related serious injuries in an inner-city entertainment precinct. DESIGN, SETTING AND PARTICIPANTS: A blinded retrospective analysis of data from the Emergency Department Information System (EDIS) of the major trauma and teaching hospital (St Vincent's Hospital, Darlinghurst) in the Sydney CBD Entertainment Precinct. Data for trauma cases classified as Australasian triage categories 1 (immediately life-threatening) and 2 (imminently life-threatening, important time-critical treatment, very severe pain) in the 12 months before (24 February 2013 - 23 February 2014; period 1) and the 12 months after (24 February 2014 - 23 February 2015; period 2) the 2014 changes to liquor licensing regulations applied to the precinct...
November 2, 2015: Medical Journal of Australia
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