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Zhichao Xiao, Yuting Luo, Guiying Wang, Changrong Ge, Guanghong Zhou, Wangang Zhang, Guozhou Liao
BACKGROUND: Boiled Wuding chicken was produced using whole chicken by washing, boiling 1 h with salt, deep frying and boiling 2 h. The effect of process on the WLOM (water-soluble lower molecule) profiles of products was characterized using proton nuclear magnetic resonance spectroscopy (1 H-NMR) and fatty acid composition of products was analyzed using gas chromatography-mass spectrometry (GC-MS). RESULTS: The metabonome was dominated by 49 WLOM and 22 fatty acid compounds were detected...
June 13, 2018: Journal of the Science of Food and Agriculture
Zhiyong Du, Zeliu Shu, Wei Lei, Chun Li, Kewu Zeng, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang
Myocardial ischemia (MI) is an escalating public health care burden worldwide. Baoyuan decoction (BYD) is a traditional Chinese medicine formula with cardioprotective activity; however, its pharmacological characteristics and mechanisms are obscured. Herein, a multi-omics strategy via incorporating the metabonomics, transcriptomics, and pharmacodynamics was adopted to investigate the effects and molecular mechanisms of BYD for treating MI in a rat model of left anterior descending coronary artery (LADCA) ligation...
2018: Frontiers in Pharmacology
Yang Liu, Jun Li, Ye Jin, Lei Zhao, Fuya Zhao, Jing Feng, Aidong Li, Yunwei Wei
Dysbiosis of gut microbiota and metabolome is a frequently encountered condition in liver cirrhosis (LC) patients. The severity of liver dysfunction was found to be correlated with the degree of microbial dysbiosis. Several clinical studies have indicated liver function improvement after therapeutic splenectomy for LC-induced hypersplenism. We sought to determine whether such post-splenectomy outcome is pertinent to modulation of the abnormal gut microenvironment in LC patients. A cross-sectional study including 12 LC patients and 16 healthy volunteers was first conducted, then a before-after study in the cohort of patients was carried out before and 6 months after splenectomy...
2018: Frontiers in Microbiology
Amy Elizabeth Johnson, Kate Louise Sidwick, Vasil R Pirgozliev, Anthony Edge, David Frederick Thompson
Metabonomic techniques have been used to discover subtle differences in the small molecule profiles of chicken eggs, which could help to combat fraud within the egg industry. High Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (HPLC-Q-ToF-MS) was used to obtain profiles of the small molecules present in the yolks of chicken eggs stored for different lengths of time. Statistical analysis, including the use of XCMS Online and further exploratory statistics, was able to uncover differences in the abundances of several of the small molecules found in these egg yolks...
May 29, 2018: Analytical Chemistry
Wenxing Liu, Fei Mu, Tianlong Liu, Hang Xu, Jianzhong Chen, Na Jia, Yikai Zhang, Fang Dou, Lei Shi, Yuwen Li, Aidong Wen, Yi Ding
Terminalia chebula (TC), a kind of Combretaceae, is a widely used herb in India and East Asia to treat cerebrovascular diseases. However, the potential mechanism of the neuroprotective effects of TC at the metabonomics level is still not unclear. The present study focused on the effects of TC on metabonomics in stroke model. In our study, rats were divided randomly into Sham, Model, and TC groups. The TC group were intragastricly administered with TC for 7 days after middle cerebral artery occlusion (MCAO) operation...
May 28, 2018: Rejuvenation Research
Qin Yang, Lu Xu, Li-Juan Tang, Jiang-Tao Yang, Ben-Qing Wu, Nan Chen, Jian-Hui Jiang, Ru-Qin Yu
Metabonomics has been widely used in disease diagnosis and clinically practical methods often require the detection of multi-class bio-samples. In this work, multi-class classification methods were investigated to simultaneously discriminate among 6 inherited metabolic diseases (IMDs) and the normal instances using gas chromatography-mass spectrometry (GC-MS) of urine samples. Two common multi-class classification strategies, one-against-all (OAA) and one-against-one (OAO) were compared and enhanced using a novel ensemble classification strategy (ECS), which developed a set of sequential sub-classifiers by fusion of OAA and OAO and made the final classification decisions using softmax function...
August 15, 2018: Talanta
Yuetao Liu, Wenqian Xu, GuoHong Wang, Xuemei Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Huangqi Jianzhong Tang (HQJZ), a celebrated traditional Chinese medicine (TCM), is commonly used for treatment of chronic atrophic gastritis (CAG) in China. AIM OF THE STUDY: We aimed to screen out the material basis of HQJZ against CAG. MATERIALS AND METHODS: CAG rat model was constructed by alternant administrations of ammonia solution and sodium deoxycholate, and the hunger disorder method. Body weight, biochemical indexes and histopathological exam were used to evaluate the efficacy of HQJZ...
May 16, 2018: Journal of Ethnopharmacology
Michael Cannon, Deepa Khambe, Malgorzata Klukowska, David L Ramsey, Melanie Miner, Tom Huggins, Donald J White
OBJECTIVES: The clinical effects of stannous fluoride (SnF2) dentifrice in reducing symptoms of gingivitis and reducing the virulence of subgingival plaque through suppression of activation of gene expression in toll receptor based reporter cells were previously reported. This study expanded analysis of the clinical study to include evaluation of dentifrice effects on salivary metabolites using 1H Nuclear Magnetic Resonance (1H NMR) systems biology-based metabonomics. METHODS: The clinical design was reported previously (J Clin Dent2017;28:16-26)...
March 2018: Journal of Clinical Dentistry
Yueli Chen, Jinquan Li, Zhongxue Yuan, Jianghua Feng, Zhong Chen
Core-shell structured Fe3 O4 @SiO2 -NH2 nanoparticles (Fe@Si-NPs) demonstrated outstanding potentials in drug targeting and delivery and medical imaging. However, they have limited clinical applications due to unknown chronic bio-effects and potential bio-related risks. In this study, the subchronic biological effects and metabolic fate of 20 nm Fe@Si-NPs in Sprague-Dawley rats in 12 weeks were investigated by the biochemical assay and NMR-based metabonomic analysis using an intravenous model. Biofluids (plasma and urine) analysis provided the transportation, absorption, and excretion information of Fe@Si-NPs...
May 10, 2018: Nanotoxicology
Saleh Alseekh, Alisdair R Fernie
The term metabolome was coined in 1998, by analogy to genome, transcriptome and proteome. The first research papers using the terms metabolomics, metabonomics, metabolic profiling or metabolite profiling were published shortly thereafter. In this short review we reflect on the major achievements brought about by use of these approaches and document knowledge and technology gaps which are currently constraining its further development. Finally, we detail why we think that the time is ripe to refocus our efforts on the understanding of metabolic function...
May 7, 2018: Plant Journal: for Cell and Molecular Biology
Chen-Yadai Yu, Jin-Gao Yu, Jun-Fei Gu, Shu-Lan Su, Yong-Qing Hua, Jin-Ao Duan
To evaluate the effect and mechanism of aerial parts of Salvia miltiorrhiza(SM) on high sugar-induced Drosophila melanogaster metabolic disorder model. The levels of glucose, triglyceride and protein in SM were detected; nymphosis time was recorded, and the reliability of metabolic disorder model as well as the mechanism of aerial parts of SM were evaluated based on metabonomics. The results showed that the levels of glucose and triglyceride in model group were significantly higher than those in normal control group( P <0...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Jiao-Ying Ma, Rui-Yu Han, Jing Ma, Shu-Song Wang
Metabonomics is an emerging branch of science for the study of endogenous small molecule metabolites in organisms, which plays an important role in evaluatingthediagnosis and treatment of male infertility by exploring the metabolites of body fluids, cells and tissues. With its advantages ofmass information, noninvasiveness, and celerity, metabonomics will be widely applied to clinical researches in the future. This review introducesmetabonomics and its analytical techniques and data processing procedures,its latest application in the studies of the etiology, diagnosis and the treatment of male infertility, and the prospect of its future application in the researches of male reproduction...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
Qingling Hua, Lin Wang, Chan Liu, Lingling Han, Yazhong Zhang, Hu Liu
To date, there have been a limited number of useful biomarkers for the screening and monitoring of B-cell non-Hodgkin's lymphoma (B-NHL), which leads to the impetus to discover novel biomarkers for the disease. In the present study, gas chromatography-mass spectrometry (GC-MS) combined with head-space solid-phase micro-extraction (HS-SPME) was employed to analyze the volatile metabolites in the urine samples of 131 subjects. The subjects were divided into 4 main groups: Aggressive B-NHL, indolent B-NHL, benign lymphatic diseases patients and healthy volunteers...
May 2018: Oncology Letters
Zhongxue Yuan, Rui Xu, Jinquan Li, Yueli Chen, Binghui Wu, Jianghua Feng, Zhong Chen
Background: Core-shell-structured nanoparticles (NPs) have attracted much scientific attention due to their promising potential in biomedical fields in recent years. However, their underlying mechanisms of action and potential adverse effects following administration remain unknown. Methods: In the present study, a 1 H nuclear magnetic resonance-based metabonomic strategy was applied to investigate the metabolic consequences in rats following the intravenous administration of parent NPs of core-shell-structured nanoparticles, Fe3 O4 @SiO2 -NH2 (Fe@Si) NPs...
2018: International Journal of Nanomedicine
Meng Li, Jia Yue Chen, Jing Fang Xie, Jia Li Lyu, Shao Long Gao, Rui Qing Liu
To investigate the influences of sewage and cadmium combined stress on maize seedling metabolites, we took GC-MS metabonomics technology to analyze the metabolite species, content and metabolic pathways. A total of 50 kinds of metabolites were identified. Under single stress of Cd, the malic acid content in maize seedling decreased, the citric acid content increased significantly, and the tricarboxylic acid cycle was relatively stable. Under the combined stress, both malic acid and citric acid contents increased significantly, and the tricarboxylic acid cycle was inhibited...
November 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Dorsa Varshavi, Flora H Scott, Dorna Varshavi, Sunil Veeravalli, Ian R Phillips, Kirill Veselkov, Nicole Strittmatter, Zoltan Takats, Elizabeth A Shephard, Jeremy R Everett
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5 , slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male, wild-type C57BL/6J and Fmo5 -/- (FMO5 KO) mice back-crossed onto the C57BL/6J background. The aim of this study was to identify metabolic signatures that are associated with ageing in both these mouse lines and to characterize the age-related differences in the metabolite profiles between the FMO5 KO mice and their wild-type counterparts at equivalent time points...
2018: Frontiers in Molecular Biosciences
Xiye Wang, Dan Li, Mingyang Jiang, Zhili Pei, Liang Xu
As a traditional Mongolian medicine, Sendeng-4 (SD) has been widely used to treat rheumatoid arthritis (RA) in Inner Mongolia and exhibits a good curative effect. Unfortunately, due to geographical factors, it is difficult to popularize this drug throughout the whole country, and the mechanism of action of SD has been unclear. In this study, a serum metabolite profile analysis was performed to identify potential biomarkers associated with adjuvant-induced RA and investigate the mechanism of action of SD. Ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was performed for the metabonomics analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
C Cao, H Shi, M Zhang, L Bo, L Hu, S Li, S Chen, S Jia, Y J Liu, Y L Liu, X Zhao, L Zhang
This study assessed the effects of long-term, low-dose acrylamide (AA) administration in rats using ultra-performance liquid chromatography-mass spectrometry. Forty male Wistar rats were randomly divided into the following four groups: control, low-dose AA (0.2 mg/kg BW), middle-dose AA (1 mg/kg BW), and high-dose AA (5 mg/kg BW). AA was administered to rats via drinking water ad libitum. After 16-week treatment, rat serum was collected for metabonomic analysis. Biochemical tests were further conducted to verify metabolic alterations...
January 1, 2018: Human & Experimental Toxicology
Jordi Mayneris-Perxachs, Jonathan R Swann
Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight metabolites in a sample providing a comprehensive assessment of the individual's biochemical status. There are a growing number of studies applying such approaches to characterize the metabolic derangements induced by various forms of early-life malnutrition...
April 11, 2018: European Journal of Nutrition
Syeda M Hussain, Valdo Rodrigues Herling, Paulo Henrique Mazza Rodrigues, Ishrat Naz, Hamayun Khan, Muhammad Tahir Khan
Photosensitization is severe dermatitis or oxidative/chemical changes in the epidermal tissues activated by the light-induced excitation of molecules within the tissue. It is a series of reactions mediated through light receptors and is more common when the plant-produced metabolites are heterocyclic/polyphenols in nature. The areas affected are exposed body parts and mostly non-pigmented areas with least ultraviolet protection. Similarly, cellular alteration also occurs in the affected animal's dermal tissues and body parts and grazing animals by the accumulation and activation of photodynamic molecules...
June 2018: Tropical Animal Health and Production
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