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https://www.readbyqxmd.com/read/28538412/biomarkers-of-unstable-angina-pectoris-and-yangxin-decoction-intervention-an-exploratory-metabonomics-study-of-blood-plasma
#1
Xiao-Hong Yu, Jing Sun, Yan Wang, Ya-Bin Zhou
BACKGROUND: This study aimed to explore the related metabolic biomarkers and to observe the effects of Yangxin Decoction (YXD) on plasma metabolism of patients with unstable angina (UA). METHODS: In total, 10 patients with UA (intervention group) and 10 healthy participants (control group) were recruited for this study from January 2009 to December 2010. Plasma samples from both groups were analyzed using liquid chromatography mass spectrometry (LC-MS). Principle component analysis (PCA) and partial least squares (PLS) were used to explore the correlations between metabolic markers in patients with UA...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28511119/effects-of-breviscapine-on-amyloid-beta-1-42-induced-alzheimer-s-disease-mice-a-hplc-qtof-ms-based-plasma-metabonomics-study
#2
Hongjun Xia, Lingling Wu, Mengying Chu, Huimin Feng, Chunliang Lu, Qinghe Wang, Minghai He, Xiaoqun Ge
Herba Erigerontis has long been used to cure apoplexy hemiplegia and precordial pain in China. In addition, the bioactivities of its total flavonoids-breviscapine included inhibiting amyloid beta (Aβ) fibril formation, antioxidation and metal chelating, which are beneficial to treat Alzheimer's disease (AD). Hence, A HPLC-QTOF-MS based plasma metabonomics approach was applied to investigate the neuroprotective effects of breviscapine on intracerebroventricular injection of aggregated Aβ 1-42 induced AD mice for the first time in the study...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28508092/a-metabonomic-analysis-on-the-response-of-enterobacter-cloacae-from-coastal-outfall-for-land-based-pollutant-under-phoxim-stress
#3
Dijun Zhang, Shan He, Tinghong Ming, Chenyang Lu, Jun Zhou, Xiurong Su
Enterobacter cloacae is an opportunistic pathogen widely distributed in human and animal intestinal systems. The secretion of extended-spectrum β-lactamases (ESBLs) and cephalosporinase (AmpC) endows E. cloacae with strong drug resistance. In a previous study by our group, protein expression of E. cloacae under phoxim stress was measured by two-dimensional electrophoresis. Here, nuclear magnetic resonance was used to detect differences in E. cloacae metabonomics when under phoxim stress. We determined that there are 29 types of metabolites that differ between phoxim stress and normal culture conditions...
May 15, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28496060/rapid-detection-of-small-molecule-metabolites-in-serum-of-hepatocellular-carcinoma-patients-using-ultrafast-liquid-chromatography-ion-trap-time-of-flight-tandem-mass-spectrometry
#4
Hui Li, Su-Fang Fan, Yan Wang, Shi-Gang Shen, Dian-Xing Sun
A method was developed for analyzing broad spectrum small molecule metabolites in the serum of hepatocellular carcinoma (HCC) patients based on ultrafast liquid chromatography-ion trap-time of flight tandem mass spectrometry (UFLC-IT-TOF MS). Serum samples were collected from 80 HCC patients and healthy persons. After pretreatment process for protein precipitation, the supernatant was analyzed with the UFLC-IT-TOF MS to obtain information on the metabonomics of small molecules. The eight compounds of glycocholic acid, choline glycerophosphate, acetyl-L-phenylalanine, oleamide, tetradecanamide, acetylcarnitine, lysolecithin and glycochenodeoxycholic acid in the HCC group were identified with significant differences from those in the health group (P <0...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28487702/organ-specific-differential-nmr-based-metabonomic-analysis-of-soybean-glycine-max-l-merr-fruit-reveals-the-metabolic-shifts-and-potential-protection-mechanisms-involved-in-field-mold-infection
#5
Jun-Cai Deng, Cai-Qiong Yang, Jing Zhang, Qing Zhang, Feng Yang, Wen-Yu Yang, Jiang Liu
Prolonged, continuous rainfall is the main climatic characteristic of autumn in Southwest China, and it has been found to cause mildew outbreaks in pre-harvest soybean fields. Low temperature and humidity (LTH) stress during soybean maturation in the field promotes pre-harvest mildew, resulting in damage to different organs of soybean fruits to different extents, but relatively little information on the resistance mechanisms in these fruits is available. Therefore, to understand the metabolic responses of soybean fruits to field mold (FM), the metabonomic variations induced by LTH were characterized using proton nuclear magnetic resonance spectroscopy ((1)H-NMR), and the primary metabolites from the pod, seed coat and cotyledon of pre-harvest soybean were quantified...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28487615/urinary-metabolomics-analysis-identifies-key-biomarkers-of-different-stages-of-nonalcoholic-fatty-liver-disease
#6
Shu Dong, Zong-Ying Zhan, Hong-Yan Cao, Chao Wu, Yan-Qin Bian, Jian-Yuan Li, Gen-Hong Cheng, Ping Liu, Ming-Yu Sun
AIM: To identify a panel of biomarkers that can distinguish between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), and explore molecular mechanism involved in the process of developing NASH from NAFLD. METHODS: Biomarkers may differ during stages of NAFLD. Urine and blood were obtained from non-diabetic subjects with NAFLD and steatosis, with normal liver function (n = 33), from patients with NASH, with abnormal liver function (n = 45), and from healthy age and sex-matched controls (n = 30)...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28465515/salmonella-typhimurium-infection-reduces-schistosoma-japonicum-worm-burden-in-mice
#7
Xiaoyang Zhu, Lu Chen, Junfang Wu, Huiru Tang, Yulan Wang
Coinfection of microorganisms is a common phenomenon in humans and animals. In order to further our understanding of the progress of coinfection and the possible interaction between different pathogens, we have built a coinfection mouse model with Schistosoma japonicum and Salmonella typhimurium, and used this model to investigate the systemic metabolic and immune responses using NMR-based metabonomics and immunological techniques. Our results show that Salmonella typhimurium (ATCC14028) infection reduces the number of adult schistosomal worms and eggs, relieves symptoms of schistosomiasis and also abates the mortality of mice infected by Schistosoma japonicum...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425490/urinary-and-fecal-metabonomics-study-of-the-protective-effect-of-chaihu-shu-gan-san-on-antibiotic-induced-gut-microbiota-dysbiosis-in-rats
#8
Meng Yu, Hong-Mei Jia, Chao Zhou, Yong Yang, Li-Li Sun, Zhong-Mei Zou
Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used in the treatment of various gastrointestinal (GI) disorders. The present study was carried out to investigate whether CSGS modulates the host metabolic phenotype under the condition of gut microbiota dysbiosis. The metabonomics studies of biochemical changes in urine and feces of antibiotic-induced gut microbiota dysbiosis rats after treatment with CSGS were performed using UPLC-Q-TOF/MS...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420467/-study-of-plasma-amino-acid-related-metabolites-of-septic-rats-using-gas-chromatography-mass-spectrometry
#9
Jin Su, Yimin Zhu, Yu Jiang, Lianhong Zou, Xiaoliang Liu, Yixiao Xu
OBJECTIVE: To reveal the pathophysiological changes of sepsis, the plasma metabonomics of septic rats was determined and differential metabolites were determined by gas chromatography-mass spectrometry (GC-MS). METHODS: Male Spraguee-Dawley (SD) rats about 8 weeks were randomly divided into sham group (n = 18) and sepsis group (n = 24). Cecal ligation and puncture (CLP) was used to build sepsis model, while cecum was kept intact only in the sham group. 6 hours after the operation, rats were anesthetized, and blood was harvested through heart thoracotomy...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28415762/metabonomics-studies-on-serum-and-urine-of-patients-with-breast-cancer-using-1h-nmr-spectroscopy
#10
Jianping Zhou, Yanxia Wang, Xinli Zhang
The aim of this study was to describe a metabolomic study of breast cancer using 1H-NMR combined with bioinformatics analysis. 1H-NMR spectroscopy combined with multi-variate pattern recognition analysis was used to cluster the groups (serum and urine samples from breast cancer patients and healthy controls) and establish a breast-cancer-specific metabolites phenotype. Orthogonalpartial least-squares discriminant analysis (OPLS-DA) was capable of distinguishing serum and urine samples from breast cancer patients and healthy controls and establishing a breast-cancer-specific metabolite profile...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28398557/the-2-oxoglutarate-dependent-dioxygenase-superfamily-participates-in-tanshinone-production-of-salvia-miltiorrhiza
#11
Zhichao Xu, Jingyuan Song
Highly oxidized tanshinones are pharmacological ingredients extracted from the medicinal model plant Salvia miltiorrhiza and are mainly used to treat cardiovascular diseases. Previous studies have confirmed that cytochrome P450 mono-oxygenases (CYP450s) have a key function in the biosynthesis of tanshinones; however, no solid evidence links oxidation to the 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily. Here, we identified 132 members of the DOXB and DOXC subfamilies of 2OGD by scanning the 2OG-FeII Oxy domain using a genome-wide strategy in S...
April 8, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28373121/metabonomics-based-analysis-of-brachyspira-pilosicoli-s-response-to-tiamulin-reveals-metabolic-activity-despite-significant-growth-inhibition
#12
Caroline Ivanne Le Roy, Jade Louise Passey, Martin John Woodward, Roberto Marcello La Ragione, Sandrine Paule Claus
Pathogenic anaerobes Brachyspira spp. are responsible for an increasing number of Intestinal Spirochaetosis (IS) cases in livestock against which few approved treatments are available. Tiamulin is used to treat swine dysentery caused by Brachyspira spp. and recently has been used to handle avian intestinal spirochaetosis (AIS). The therapeutic dose used in chickens requires further evaluation since cases of bacterial resistance to tiamulin have been reported. In this study, we evaluated the impact of tiamulin at varying concentrations on the metabolism of B...
March 31, 2017: Anaerobe
https://www.readbyqxmd.com/read/28371309/comprehensive-metabonomic-analysis-of-heart-tissue-from-isoproterenol-induced-myocardial-infarction-rat-based-on-reversed-phase-and-hydrophilic-interaction-chromatography-coupled-to-mass-spectrometry
#13
Lei Sun, Jianxun Liu, Mingqian Sun, Li Lin, Lan Miao, Zhengyan Ge, Bin Yang
We aim to describe the metabonomic characteristics of myocardial infarction rats. High-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was utilized to develop a metabonomic method of the heart homogenates of myocardial infarction rats. Hydrophilic interaction chromatography allows the analysis of high polar metabolites, providing complementary information to reversed-phase liquid chromatography. We combined reversed phase and hydrophilic interaction chromatographic separations to analyze 18 samples, ten from myocardial infarction rat hearts and eight from normal rat hearts...
March 29, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28367224/qgqs-granule-in-shr-serum-metabonomics-study-based-on-tools-of-uplc-q-tof-and-renin-angiotensin-aldosterone-system-form-protein-profilin-1
#14
Ke Li, Caicai Li, Jialong Wang, Hanming Cui, Yu Dong, Ruihua Liu, Yuanhui Hu
QGQS granule is effective for the therapeutic of hypertension in clinic. The aim of this research is to observe the antihypertension effect of QGQS granule on SHR and explain the mechanism of its lowering blood pressure. 30 SHR were selected as model group, captopril group, and QGQS group, 10 WKYr were used as control group, and RBP were measured on tail artery consciously. And all the serum sample analysis was carried out on UPLC-TOF-MS system to determine endogenous metabolites and to find the metabonomics pathways...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28363136/urinary-metabonomics-study-of-the-hepatoprotective-effects-of-total-alkaloids-from-corydalis-saxicola-bunting-on-carbon-tetrachloride-induced-chronic-hepatotoxicity-in-rats-using-1-h-nmr-analysis
#15
Fang Wu, Hua Zheng, Zheng-Teng Yang, Bang Cheng, Jin-Xia Wu, Xu-Wen Liu, Chao-Ling Tang, Shi-Yin Lu, Zhao-Ni Chen, Fang-Ming Song, Jun-Xiang Ruan, Hong-Ye Zhang, Yong-Hong Liang, Hui Song, Zhi-Heng Su
Chronic liver injury has been shown to cause liver fibrosis due to the sustained pathophysiological wound healing response of the liver, and eventually progresses to cirrhosis. The total alkaloids of Corydalis saxicola Bunting (TACS), a collection of important bioactive ingredients derived from the traditional Chinese folk medicine Corydalis saxicola Bunting (CS), have been reported to have protective effects on the liver. However, the underlying molecular mechanisms need further elucidation. In this study, the urinary metabonomics and the biochemical changes in rats with carbon tetrachloride (CCl4)-induced chronic liver injury due to treatment TACS or administration of the positive control drug-bifendate were studied via proton nuclear magnetic resonance ((1)H NMR) analysis...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28359851/characterization-of-a-protein-bound-polysaccharide-from-herba-epimedii-and-its-metabolic-mechanism-in-chronic-fatigue-syndrome
#16
Aiping Chi, Zhimei Shen, Wenfei Zhu, Yuliang Sun, Yijiang Kang, Fei Guo
OBJECTIVES: Herba Epimedii is one of the famous Traditional Chinese Medicines used to treat the chronic fatigue syndrome (CFS). The polysaccharides are the main active components in H. epimedii. The aim of this study is to discover the therapeutic effect and metabolic mechanism of H. epimedii polysaccharides against CFS. METHODS: The polysaccharide conjugates named HEP2-a were isolated from the leaves of H. epimedii using a water extraction method, and the general physicochemical properties of HEP2-a were analysed...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28345376/lessons-from-metabonomics-on-the-neurobiology-of-stroke
#17
Mahim I Qureshi, Panagiotis A Vorkas, Alexander P Coupland, I Harri Jenkins, Elaine Holmes, Alun H Davies
The application of metabonomic science to interrogate stroke permits the study of metabolite entities, small enough to cross the blood-brain barrier, that provide insight into neuronal dysfunction, and may serve as reservoirs of biomarker discovery. This systematic review examines the applicability of metabolic profiling in ischemic stroke research. Six human studies utilizing metabolic profiling to analyze biofluids from ischemic stroke patients have been included, employing (1)H-NMR and/or mass spectrometry to analyze plasma, serum, and/or urine in a targeted or untargeted fashion...
October 1, 2016: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28343458/association-between-urinary-metabolic-profile-and-the-intestinal-effects-of-cocoa-in-rats
#18
Malen Massot-Cladera, Jordi Mayneris-Perxachs, Adele Costabile, Jonathan R Swann, Àngels Franch, Francisco J Pérez-Cano, Margarida Castell
The aim of this study was to elucidate the relationship between the urinary metabolic fingerprint and the effects of cocoa and cocoa fibre on body weight, hormone metabolism, intestinal immunity and microbiota composition. To this effect, Wistar rats were fed, for 3 weeks, a diet containing 10 % cocoa (C10) or two other diets with same the proportion of fibres: one based on cocoa fibre (CF) and another containing inulin as a reference (REF) diet. The rats' 24 h urine samples were analysed by an untargeted 1H NMR spectroscopy-based metabonomic approach...
March 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28322967/regulating-dyslipidemia-effect-of-polysaccharides-from-pleurotus-ostreatus-on-fat-emulsion-induced-hyperlipidemia-rats
#19
Yan Zhang, Zhuowei Wang, Gang Jin, Xiudong Yang, Hongli Zhou
This study was conducted to evaluate the regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus (POP) on fat-emulsion-induced hyperlipidemia rats. A plasma metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied to analyze the holistic mechanism of POP in a hyperlipidemia rat model. Multivariate statistical approaches such as principal component analysis and orthogonal projection to latent structure square-discriminant analysis revealed distinctions among the control, hyperlipidemia model, and POP groups...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28322061/potential-biomarkers-for-monitoring-the-toxicity-of-long-term-exposure-to-atrazine-in-rat-by-metabonomic-analysis
#20
Xiao-Feng Zhang, Chong-Hua Zhang, Jing Zheng, Long-Xue Li, Tian-Qi Geng, Yang Zhang
1. Herbicide atrazine (ATR) poses harmful effects on human health. The purpose of this study is to study potential biomarkers used for monitoring the toxic effects after chronic exposure to ATR by studying urine metabolites. 2. Rats were assigned into clinical chemistry and metabonomics arms, and each arm was divided into low-dose, high-dose and control groups. ATR was administered to rats along with their feed. At the end of 16, 20 and 24 weeks, clinical parameters and histopathologic changes was assessed to monitor the toxic effects...
March 21, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
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