Xinhai Huang, Wenlin Xu, Guilan Wu, Ruijuan Li, Ping Gu, Qiaowei Zheng, Xiumei Liu, Hengfen Dai, Xiangsheng Lin, Yuxin Liu, Xiaoming Du, Jun Su, Wang Zhang, Min Zhang, Zhu Zhu, Xiaohong Huang, Nianxu Huang, Jinhua Zhang
BACKGROUND: The efficacy and safety of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients with impaired liver function (ILF) have not been sufficiently studied. The aim of this study was to evaluate the efficacy and safety of DOACs for stroke prevention in patients with AF and ILF. METHOD: This study was based on data from 15 centers in China, including 4,982 AF patients. The patients were divided into 2 subgroups based on their liver function status: patients with normal liver function (NLF)(n = 4213) and patients with ILF (n = 769)...
April 12, 2024: European Journal of Clinical Pharmacology