keyword
https://read.qxmd.com/read/38521168/poly-d-l-lactide-co-glycolide-particles-are-metabolised-by-the-gut-microbiome-and-elevate-short-chain-fatty-acids
#21
JOURNAL ARTICLE
Laura E McCoubrey, Fabiana Ferraro, Nidhi Seegobin, Jérémy Verin, Haya A Alfassam, Atheer Awad, Massimo Marzorati, Lynn Verstrepen, Jonas Ghyselinck, Julie De Munck, Jelle De Medts, Evi Steppe, Valerie De Vleeschhauwer, Gilles De Rocker, Alexandra Droesbeke, Melanie De Rijck, Sara Vanthoor, Frédéric Moens, Juergen Siepmann, Florence Siepmann, Simon Gaisford, Mine Orlu, Abdul W Basit
The production of short chain fatty acids (SCFAs) by the colonic microbiome has numerous benefits for human health, including maintenance of epithelial barrier function, suppression of colitis, and protection against carcinogenesis. Despite the therapeutic potential, there is currently no optimal approach for elevating the colonic microbiome's synthesis of SCFAs. In this study, poly(D,l-lactide-co-glycolide) (PLGA) was investigated for this application, as it was hypothesised that the colonic microbiota would metabolise PLGA to its lactate monomers, which would promote the resident microbiota's synthesis of SCFAs...
March 21, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38521039/exposure-to-flutolanil-at-environmentally-relevant-concentrations-can-induce-image-and-non-image-forming-failure-of-zebrafish-larvae-through-neuro-and-visual-disruptions
#22
JOURNAL ARTICLE
Yang Yang, Bin He, Xiyan Mu, Suzhen Qi
Numerous pesticides pose a threat to aquatic ecosystems, jeopardizing aquatic animal species and impacting human health. While the contamination of aquatic environment by flutolanil and its adverse effects on animal in the treatment of rich sheath blight have been reported, the neuro-visual effects of flutolanil at environmentally relevant concentrations remain unknown. In this study, we administered flutolanil to zebrafish embryos (0, 0.125, 0.50 and 2.0 mg/L) for 4 days to investigate its impact on the neuro and visual system...
March 21, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38519882/hpv-associated-cervicovaginal-microbiome-and-host-metabolome-characteristics
#23
JOURNAL ARTICLE
Yao Zhang, Xu Wu, Dan Li, Rong Huang, Xiangyu Deng, Mingxing Li, Fukuan Du, Yueshui Zhao, Jing Shen, Yu Chen, Pingxiu Zhang, Congcui Hu, Zhangang Xiao, Qinglian Wen
BACKGROUND: Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively...
March 22, 2024: BMC Microbiology
https://read.qxmd.com/read/38518717/development-and-validation-of-a-versatile-non-invasive-urinary-steroidomics-method-for-wildlife-biomonitoring
#24
JOURNAL ARTICLE
Tom Cools, Kirsten S Wilson, Desheng Li, Catherine Vancsok, Baptiste Mulot, Antoine Leclerc, José Kok, Marko Haapakoski, Mads F Bertelsen, Andreas Ochs, Simon J Girling, Yingmin Zhou, Rengui Li, Lynn Vanhaecke, Jella Wauters
Wildlife conservation is often challenged by a lack of knowledge about the reproduction biology and adaptability of endangered species. Although monitoring steroids and related molecules can increase this knowledge, the applicability of current techniques (e.g. immunoassays) is hampered by species-specific steroid metabolism and the requisite to avoid invasive sampling. This study presents a validated steroidomics method for the (un)targeted screening of a wide range of sex and stress steroids and related molecules in urine using ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS)...
March 19, 2024: Talanta
https://read.qxmd.com/read/38518452/identification-of-metabolites-produced-by-six-gut-commensal-bacteroidales-strains-using-non-targeted-lc-ms-ms-metabolite-profiling
#25
JOURNAL ARTICLE
Maria Victoria Fernandez-Cantos, Ambrin Farizah Babu, Kati Hanhineva, Oscar P Kuipers
As the most abundant gram-negative bacterial order in the gastrointestinal tract, Bacteroidales bacteria have been extensively studied for their contribution to various aspects of gut health. These bacteria are renowned for their involvement in immunomodulation and their remarkable capacity to break down complex carbohydrates and fibers. However, the human gut microbiota is known to produce many metabolites that ultimately mediate important microbe-host and microbe-microbe interactions. To gain further insights into the metabolites produced by the gut commensal strains of this order, we examined the metabolite composition of their bacterial cell cultures in the stationary phase...
March 20, 2024: Microbiological Research
https://read.qxmd.com/read/38518253/modulation-of-gut-microbial-metabolism-by-cyanidin-3-o-glucoside-in-mitigating-polystyrene-induced-colonic-inflammation-insights-from-16s-rrna-sequencing-and-metabolomics
#26
JOURNAL ARTICLE
Wen Chen, Xiaodong Zheng, Fujie Yan, Lizhou Xu, Xiang Ye
Microplastics derived from plastic waste have emerged as a pervasive environmental pollutant with potential transfer and accumulation through the food chain, thus posing risks to both ecosystems and human health. The gut microbiota, tightly intertwined with metabolic processes, exert substantial influences on host physiology by utilizing dietary compounds and generating bacterial metabolites such as tryptophan and bile acid. Our previous studies have demonstrated that exposure to microplastic polystyrene (PS) disrupts the gut microbiota and induces colonic inflammation...
March 22, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38517248/knock-out-of-dipeptidase-cn2-in-human-proximal-tubular-cells-disrupts-dipeptide-and-amino-acid-homeostasis-and-para-and-transcellular-solute-transport
#27
JOURNAL ARTICLE
Tilman Pfeffer, Susanne M Krug, Tamara Kracke, Robin Schürfeld, Florian Colbatzky, Philip Kirschner, Rebekka Medert, Marc Freichel, Dagmar Schumacher, Maria Bartosova, Sotiris G Zarogiannis, Martina U Muckenthaler, Sandro Altamura, Silvia Pezer, Nadine Volk, Constantin Schwab, Stefan Duensing, Thomas Fleming, Elena Heidenreich, Johannes Zschocke, Rüdiger Hell, Gernot Poschet, Claus P Schmitt, Verena Peters
AIM: Although of potential biomedical relevance, dipeptide metabolism has hardly been studied. We found the dipeptidase carnosinase-2 (CN2) to be abundant in human proximal tubules, which regulate water and solute homeostasis. We therefore hypothesized, that CN2 has a key metabolic role, impacting proximal tubular transport function. METHODS: A knockout of the CN2 gene (CNDP2-KO) was generated in human proximal tubule cells and characterized by metabolomics, RNA-seq analysis, paracellular permeability analysis and ion transport...
March 22, 2024: Acta Physiologica
https://read.qxmd.com/read/38515340/non-targeted-metabolomics-for-the-identification-of-plasma-metabolites-associated-with-organic-anion-transporting-polypeptide-1b1-function
#28
JOURNAL ARTICLE
Kreetta Hämäläinen, Päivi Hirvensalo, Mikko Neuvonen, Aleksi Tornio, Janne T Backman, Marko Lehtonen, Mikko Niemi
Our aim was to evaluate biomarkers for organic anion transporting polypeptide 1B1 (OATP1B1) function using a hypothesis-free metabolomics approach. We analyzed fasting plasma samples from 356 healthy volunteers using non-targeted metabolite profiling by liquid chromatography high-resolution mass spectrometry. Based on SLCO1B1 genotypes, we stratified the volunteers to poor, decreased, normal, increased, and highly increased OATP1B1 function groups. Linear regression analysis, and random forest (RF) and gradient boosted decision tree (GBDT) regressors were used to investigate associations of plasma metabolite features with OATP1B1 function...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38515292/acute-fetal-metabolomic-changes-in-twins-undergoing-fetoscopic-surgery-for-twin-twin-transfusion-syndrome
#29
JOURNAL ARTICLE
Braxton Forde, Samuel Martin, Miki Watanabe-Chailland, Foong-Yen Lim
Fetuses undergo major surgical stress as well as fluid shifts secondary to both twin-twin transfusion (TTTS) as well as the fetoscopic surgery for treatment of TTTS. While the pathophysiology of TTTS is understood, the acute metabolic changes that fetuses experience from fetoscopic surgery are not. We sought to evaluate the changes in recipient metabolomic profile secondary to TTTS surgery. Amniotic fluid was collected at the beginning and end of four TTTS surgical cases performed from 12/2022-2/2023. Samples were immediately processed and evaluated via NMR-based Metabolomics Facility protocol...
March 22, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38515179/cluster-specific-associations-between-the-gut-microbiota-and-behavioral-outcomes-in-preschool-aged-children
#30
JOURNAL ARTICLE
Marcel van de Wouw, Yanan Wang, Matthew L Workentine, Elnaz Vaghef-Mehrabani, Delaney Barth, Emily M Mercer, Deborah Dewey, Marie-Claire Arrieta, Raylene A Reimer, Lianne Tomfohr-Madsen, Gerald F Giesbrecht
BACKGROUND: The gut microbiota is recognized as a regulator of brain development and behavioral outcomes during childhood. Nonetheless, associations between the gut microbiota and behavior are often inconsistent among studies in humans, perhaps because many host-microbe relationships vary widely between individuals. This study aims to stratify children based on their gut microbiota composition (i.e., clusters) and to identify novel gut microbiome cluster-specific associations between the stool metabolomic pathways and child behavioral outcomes...
March 21, 2024: Microbiome
https://read.qxmd.com/read/38514519/longitudinal-aortic-strain-ventriculo-arterial-coupling-and-fatty-acid-oxidation-novel-insights-into-human-cardiovascular-aging
#31
JOURNAL ARTICLE
Hongzhou Zhang, Shuang Leng, Fei Gao, Jean-Paul Kovalik, Ru-San Tan, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, Xiaodan Zhao, John Allen, Qinghua Wu, Tim Leiner, Liang Zhong, Angela S Koh
Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted metabolomic profiling. Among community older adults without cardiovascular disease, VAC was calculated as aortic pulse wave velocity (PWV), a marker of arterial stiffness, divided by left ventricular (LV) GLS. AOGLS was the maximum absolute strain measured by tracking the phasic distance between brachiocephalic artery origin and aortic annulus...
March 22, 2024: GeroScience
https://read.qxmd.com/read/38513845/microbial-mechanisms-in-nitrogen-fertilization-modulating-the-re-mobilization-of-clay-mineral-bound-cadmium-in-agricultural-soils
#32
JOURNAL ARTICLE
Jun-Feng Wang, Can Liu, Zhi-Min Xu, Fo-Peng Wang, Yun-Yun Sun, Jia-Wei Huang, Qu-Sheng Li
Soil cadmium (Cd) can affect crop growth and food safety, and through the enrichment in the food chain, it ultimately poses a risk to human health. Reducing the re-mobilization of Cd caused by the release of protons and acids by crops and microorganisms after stabilization is one of the significant technical challenges in agricultural activities. This study aimed to investigate the re-mobilization of stabilized Cd within the clay mineral-bound fraction of soil and its subsequent accumulation in crops utilizing nitrogen ammonium nitrogen (NH4 + -N) and nitrate nitrogen (NO3 - -N), at 60 and 120 mg kg-1 ...
March 19, 2024: Science of the Total Environment
https://read.qxmd.com/read/38513779/a-metabolomics-approach-reveals-metabolic-disturbance-of-human-cholangiocarcinoma-cells-after-parthenolide-treatment
#33
JOURNAL ARTICLE
Yongping He, Qianxue Yu, Xiaoyu Ma, Diya Lv, Hui Wang, Weian Qiu, Xiao Fei Chen, Yang Jiao, Yue Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Tanacetum parthenium (L.) Schultz-Bip, commonly known as feverfew, has been traditionally used to treat fever, migraines, rheumatoid arthritis, and cancer. Parthenolide (PTL), the main bioactive ingredient isolated from the shoots of feverfew, is a sesquiterpene lactone with anti-inflammatory and antitumor properties. Previous studies showed that PTL exerts anticancer activity in various cancers, including hepatoma, cholangiocarcinoma, acute myeloid leukemia, breast, prostate, and colorectal cancer...
March 19, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38513647/transcriptomic-epigenomic-and-spatial-metabolomic-cell-profiling-redefines-regional-human-kidney-anatomy
#34
JOURNAL ARTICLE
Haikuo Li, Dian Li, Nicolas Ledru, Qiao Xuanyuan, Haojia Wu, Amish Asthana, Lori N Byers, Stefan G Tullius, Giuseppe Orlando, Sushrut S Waikar, Benjamin D Humphreys
A large-scale multimodal atlas that includes major kidney regions is lacking. Here, we employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) and spatially resolved metabolomics to profile 54 human samples from distinct kidney anatomical regions. We generated transcriptomes of 446,267 cells and chromatin accessibility profiles of 401,875 cells and developed a package to analyze 408,218 spatially resolved metabolomes. We find that the same cell type, including thin limb, thick ascending limb loop of Henle and principal cells, display distinct transcriptomic, chromatin accessibility, and metabolomic signatures, depending on anatomic location...
March 13, 2024: Cell Metabolism
https://read.qxmd.com/read/38513237/genetic-regulation-of-carnitine-metabolism-controls-lipid-damage-repair-and-aging-rbc-hemolysis-in-vivo-and-in-vitro
#35
JOURNAL ARTICLE
Travis Nemkov, Alicia Key, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel M Hay, Pascal Amireault, Madeleine Casimir, Michaël Dussiot, Monika Dzieciatkowska, Julie A Reisz, Xutao Deng, Mars Stone, Steven H Kleinman, Steven L Spitalnik, Kirk C Hansen, Philip J Norris, Gary A Churchill, Michael P Busch, Nareg H Roubinian, Grier P Page, James C Zimring, Arduino Arduini, Angelo D'Alessandro
Recent large-scale multi-omics studies suggest that genetic factors influence the chemical individuality of donated blood. To examine this concept, we performed metabolomics analyses of 643 blood units from volunteers who donated units of packed red blood cells (RBCs) on two separate occasions. These analyses identified carnitine metabolism as the most reproducible pathway across multiple donations from the same donor. We also measured L-carnitine and acyl-carnitines in 13,091 packed RBC units from donors in the Recipient Epidemiology and Donor Evaluation (REDS) study...
March 21, 2024: Blood
https://read.qxmd.com/read/38512811/harnessing-schistosoma-associated-metabolite-changes-in-the-human-host-to-identify-biomarkers-of-infection-and-morbidity-where-are-we-and-what-should-we-do-next
#36
REVIEW
Mireille Kameni, Fungai Musaigwa, Leonel Meyo Kamguia, Severin Donald Kamdem, Gladice Mbanya, Poppy H L Lamberton, Justin Komguep Nono
Schistosomiasis is the second most widespread parasitic disease affecting humans. A key component of today's infection control measures is the diagnosis and monitoring of infection, informing individual- and community-level treatment. However, newly acquired infections and/or low parasite burden are still difficult to diagnose reliably. Furthermore, even though the pathological consequence of schistosome egg sequestration in host tissues is well described, the evidence linking egg burden to morbidity is increasingly challenged, making it inadequate for pathology monitoring...
March 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38509405/large-scale-population-based-studies-of-blood-metabolome-and-brain-health
#37
JOURNAL ARTICLE
Zdenka Pausova, Eeva Sliz
Metabolomics technologies enable the quantification of multiple metabolomic measures simultaneously, which provides novel insights into molecular aspects of human health and disease. In large-scale, population-based studies, blood is often the preferred biospecimen. Circulating metabolome may relate to brain health either by affecting or reflecting brain metabolism. Peripheral metabolites may act at or cross the blood-brain barrier and, subsequently, influence brain metabolism, or they may reflect brain metabolism if similar pathways are engaged...
March 21, 2024: Current Topics in Behavioral Neurosciences
https://read.qxmd.com/read/38509170/inhibitory-effect-of-benzocaine-from-schisandra-chinensis-on-alternaria-alternata
#38
JOURNAL ARTICLE
Lin Fang Long, Qi Fang Zhao, Fu Long Zhang, Ran Tang, Jia Bao Wei, Shan Guan, Yan Chen
The clinical effects of Schisandra chinensis against human disease are well-documented; however, studies on its application in controlling plant pathogens are limited. Here, we investigated its inhibitory effect on the growth of Alternaria alternata, a fungus which causes significant post-harvest losses on apples, known as black spot disease. S. chinensis fruit extract exhibited strong inhibitory effects on the growth of A. alternata with an EC50 of 1882.00 mg/L. There were 157 compounds identified in the extract by high performance liquid chromatography-mass spectrometry, where benzocaine constituted 14...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508990/metabolomics-of-human-umbilical-vein-endothelial-cell-based-analysis-of-the-relationship-between-hyperuricemia-and-dyslipidemia
#39
JOURNAL ARTICLE
Wen Huang, Min Zhang, Qiong Qiu, Jing Zhang, Chao Hua, Geliang Chen, Hua Xie
BACKGROUND AND AIMS: Hyperuricemia frequently accompanies dyslipidemia, yet the precise mechanism remains elusive. Leveraging cellular metabolomics analyses, this research probes the potential mechanisms wherein hyperuricemia provokes endothelial cell abnormalities, inducing disordered bile metabolism and resultant lipid anomalies. METHODS AND RESULTS: We aimed to identify the differential metabolite associated with lipid metabolism through adopting metabolomics approach, and thereafter adequately validating its protective function on HUVECs by using diverse assays to measure cellular viability, reactive oxygen species, migration potential, apoptosis and gene and protein levels of inflammatory factors...
February 7, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38508901/exploiting-integrative-metabolomics-to-study-host-parasite-interactions-in-plasmodium-infections
#40
REVIEW
Maria Nikulkova, Wael Abdrabou, Jane M Carlton, Youssef Idaghdour
Despite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine metabolomics, lipidomics, transcriptomics, and genomics datasets, offer a holistic systems biology approach to studying malaria...
March 19, 2024: Trends in Parasitology
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