Stefano Tamburin, Kristian Borg, Xavier J Caro, Stefano Jann, Alexander J Clark, Francesca Magrinelli, Gen Sobue, Lars Werhagen, Giampietro Zanette, Haruki Koike, Peter J Späth, Angela Vincent, Andreas Goebel
BACKGROUND: The treatment of chronic pain is still unsatisfactory. Despite the availability of different drugs, most patients with chronic pain do not receive satisfactory pain relief or report side effects. Converging evidence implicates involvement of the immune system in the pathogenesis of different types of nociceptive and neuropathic chronic pain. DESIGN: At a workshop in Liverpool, UK (October 2012), experts presented evidence suggesting immunological involvement in chronic pain and recent data supporting the concept that the established immune-modulating drug, polyvalent immunoglobulin G (IgG), either given intravenously (IVIg) or subcutaneously (SCIg), may reduce pain in some peripheral neuropathies and a range of other pain disorders...
July 2014: Pain Medicine