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post polio syndrome treatment

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https://www.readbyqxmd.com/read/27477023/orthotic-management-of-instability-of-the-knee-related-to-neuromuscular-and-central-nervous-system-disorders-systematic-review-qualitative-study-survey-and-costing-analysis
#1
Joanne O'Connor, Dorothy McCaughan, Catriona McDaid, Alison Booth, Debra Fayter, Roccio Rodriguez-Lopez, Roy Bowers, Lisa Dyson, Cynthia P Iglesias, Simon Lalor, Rory J O'Connor, Margaret Phillips, Gita Ramdharry
BACKGROUND: Patients who have knee instability that is associated with neuromuscular disease (NMD) and central nervous system (CNS) conditions can be treated using orthoses, such as knee-ankle-foot orthoses (KAFOs). OBJECTIVES: To assess existing evidence on the effectiveness of orthoses; patient perspectives; types of orthotic devices prescribed in the UK NHS; and associated costs. METHODS: Qualitative study of views of orthoses users - a qualitative in-depth interview study was undertaken...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26286895/immunoglobulin-treatment-in-post-polio-syndrome-identification-of-responders-and-non-responders
#2
Gunilla Östlund, Lisbet Broman, Lars Werhagen, Kristian Borg
OBJECTIVE: To define and characterize responders and non-responders in a group of 124 patients with post-polio syndrome who received a single treatment with intravenous immunoglobulin. DESIGN: Open trial, prospective follow-up study. METHODS: Clinical examination and data from medical records. Short Form 36 (SF-36), Physical Activity Scale for the Elderly (PASE) and visual analogue scale (VAS) measured quality of life, physical activity and intensity of pain, respectively...
September 2015: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/26096187/headache-and-nausea-after-treatment-with-high-dose-subcutaneous-versus-intravenous-immunoglobulin
#3
Lars H Markvardsen, Ingelise Christiansen, Henning Andersen, Johannes Jakobsen
Treatment with intravenous immunoglobulin (IVIG) leads to transient side effects such as headache and nausea during and after the infusion. We hypothesized that subcutaneous administration of smaller doses of immunoglobulin (SCIG) given more frequently leads to less severe headache and nausea and could be an alternative in patients experiencing side effects. Fifty-nine patients diagnosed with neurological disorders (chronic inflammatory demyelinating polyneuropathy (CIDP), multi-focal motor neuropathy (MMN) or post-polio syndrome) were treated with IVIG, and 27 CIDP or MMN patients with SCIG...
December 2015: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/25939306/post-poliomyelitis-syndrome-as-a-possible-viral-disease
#4
REVIEW
Andreina Baj, Martina Colombo, Joan L Headley, John R McFarlane, Mary-Ann Liethof, Antonio Toniolo
This review summarizes current concepts on post-polio syndrome (PPS), a condition that may arise in polio survivors after partial or complete functional recovery followed by a prolonged interval of stable neurological function. PPS affects 15-20 million people worldwide. Epidemiological data are reported, together with the pathogenic pathways that possibly lead to the progressive degeneration and loss of neuromuscular motor units. As a consequence of PPS, polio survivors experience new weakness, generalized fatigue, atrophy of previously unaffected muscles, and a physical decline that may culminate in the loss of independent life...
June 2015: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/25379493/post-polio-syndrome-and-risk-factors-in-korean-polio-survivors-a-baseline-survey-by-telephone-interview
#5
Hyun Bang, Jee Hyun Suh, Seung Yeol Lee, Keewon Kim, Eun Joo Yang, Se Hee Jung, Soong-Nang Jang, Soo Jeong Han, Wan-Ho Kim, Min-Gyun Oh, Jeong-Hwan Kim, Sam-Gyu Lee, Jae-Young Lim
OBJECTIVE: To obtain information on the socioeconomic, medical, and functional status of polio survivors, and to use these results as the preliminary data for establishing the middle-aged cohort of polio survivors. METHODS: The subjects were recruited based on the medical records of multiple hospitals and centers. They were assessed through a structured questionnaire over the phone. Post-poliomyelitis syndrome (PPS) was identified according to the specified diagnostic criteria...
October 2014: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/25353678/-polio-late-effects-and-post-polio
#6
Lise Kay
Approximately 7,000 Danes are still living with sequelae after surviving an acute polio infection. Late effects of polio include deformities, arthrosis and overloaded muscles. In the long run polio patients are at risk of having a further decrease of muscle function and a wide variety of other symptoms, a condition called post-polio syndrome (PPS). Treatment of PPS is in general symptomatic. Recently it has been shown that treatment with intravenous immunoglobulin may have an effect on pain, tiredness and walking distance...
October 20, 2014: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/25042342/restless-legs-syndrome-in-patients-with-sequelae-of-poliomyelitis
#7
Hatice Kumru, Enric Portell, Manuela Barrio, Joan Santamaria
BACKGROUND: No studies have examined the association between RLS and the sequelae of poliomyelitis (PM). We studied the frequency and severity of RLS in a group of consecutive patients with the sequelae of poliomyelitis (PM) and the effect of treatment with dopaminergic drugs. METHODS: A diagnosis of RLS was made according to the criteria of the International RLS Study Group, and severity was assessed by the RLS rating scale. Information on sex, age, age at onset, site affected by PM, disease duration of PM, and history of post-polio syndrome (pPS) was obtained in a cohort of 52 PM patients...
October 2014: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/24960092/-musculoskeletal-symptoms-in-patients-with-post-polio-syndrome
#8
B Balzien, B Hofner, E Harlander-Weikert, P Frommelt, H Bork, R Forst, A Fujak
BACKGROUND: The prevalence of the post-polio syndrome (PPS) is in estimated 50 % of persons with established poliomyelitis with a subsequently stable phase of at least 15 years. The basic mechanism is a loss of motoneuron cells in the spinal cord resulting in muscle weakness and fatigue. In addition pain, cold intolerance and a loss of stamina are frequently reported. There are few studies focusing on the orthopaedic symptoms in the PPS. This study should support the health-care professionals to the address the needs of PPS patients...
June 2014: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/24525980/management-of-post-polio-syndrome
#9
D A Trojan, L Finch
Many patients with post-poliomyelitis syndrome can benefit from a management program. When a post-polio patient presents with new symptoms, it is first essential to identify and treat other medical and neurological conditions which could produce these symptoms. New weakness can be managed with exercise (stretching, strengthening, and aerobic), avoidance of muscular overuse, weight loss, orthoses, and assistive devices. Fatigue can be managed with energy conservation techniques, lifestyle changes, pacing, regular rest periods or naps during the day, amitriptyline to improve sleep, and possibly pyridostigmine (trial in progress)...
1997: NeuroRehabilitation
https://www.readbyqxmd.com/read/24438097/polio-survivors-perceptions-of-the-meaning-of-quality-of-life-and-strategies-used-to-promote-participation-in-everyday-activities
#10
Anita Atwal, Georgia Spiliotopoulou, Caron Coleman, Kate Harding, Caroline Quirke, Nicole Smith, Zeina Osseiran, Nicola Plastow, Lesley Wilson
INTRODUCTION: The term 'post-polio syndrome' (PPS) is used to describe new and late manifestations of poliomyelitis that occur later in life. Research in this area has focused upon health status rather than its effect on quality of life. AIM: To gain an in-depth understanding of the meaning of quality of life for polio survivors and to determine the type of strategies that are used by people with PPS and the support that they consider as important to facilitate participation in everyday life activities that have an impact on their quality of life...
October 2015: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/24422915/immunoglobulin-g-for-the-treatment-of-chronic-pain-report-of-an-expert-workshop
#11
Stefano Tamburin, Kristian Borg, Xavier J Caro, Stefano Jann, Alexander J Clark, Francesca Magrinelli, Gen Sobue, Lars Werhagen, Giampietro Zanette, Haruki Koike, Peter J Späth, Angela Vincent, Andreas Goebel
BACKGROUND: The treatment of chronic pain is still unsatisfactory. Despite the availability of different drugs, most patients with chronic pain do not receive satisfactory pain relief or report side effects. Converging evidence implicates involvement of the immune system in the pathogenesis of different types of nociceptive and neuropathic chronic pain. DESIGN: At a workshop in Liverpool, UK (October 2012), experts presented evidence suggesting immunological involvement in chronic pain and recent data supporting the concept that the established immune-modulating drug, polyvalent immunoglobulin G (IgG), either given intravenously (IVIg) or subcutaneously (SCIg), may reduce pain in some peripheral neuropathies and a range of other pain disorders...
July 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/24322288/-polio-paralytic-new-problems-postpolio-syndrome
#12
Jesús Esteban
In 1875 M. Raymond described a progressive muscle wasting and weakness in 3 individuals survivors of childhood acute poliomyelitis. Jean-Martin Charcot suggested that the initial injury should let these guys neurons more sensitive to develop posterior spinal diseases and new weakness was the result of overuse of the affected muscles. In 1979, after the publication of the description given by a 57 year old patient on motor difficulties that developed after suffering of polio in childhood, there was a very significant increase of comments of other individuals with similar symptoms, reaching wedged in the 80s the term of post-polio syndrome...
September 2013: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/24312590/efficacy-of-modafinil-on-fatigue-and-excessive-daytime-sleepiness-associated-with-neurological-disorders-a-systematic-review-and-meta-analysis
#13
REVIEW
Ping Sheng, Lijun Hou, Xiang Wang, Xiaowen Wang, Chengguang Huang, Mingkun Yu, Xi Han, Yan Dong
BACKGROUND: Modafinil is a novel wake-promoting agent approved by the FDA ameliorating excessive daytime sleepiness (EDS) in three disorders: narcolepsy, shift work sleep disorder and obstructive sleep apnea. Existing trials of modafinil for fatigue and EDS associated with neurological disorders provided inconsistent results. This meta-analysis was aimed to assess drug safety and effects of modafinil on fatigue and EDS associated with neurological disorders. METHODS: A comprehensive literature review was conducted in order to identify published studies assessing the effects of modafinil on fatigue and EDS associated with neurological disorders...
2013: PloS One
https://www.readbyqxmd.com/read/24180709/hemolytic-anemia-following-high-dose-intravenous-immunoglobulin-in-patients-with-chronic-neurological-disorders
#14
L H Markvardsen, I Christiansen, T Harbo, J Jakobsen
BACKGROUND AND PURPOSE: High dose intravenous immunoglobulin (IVIG) is an established treatment for various neuromuscular disorders. Recently, cases of hemolytic anemia following IVIG have been observed. The objective of this study was to determine the extent of anemia and hemolysis after IVIG and its relationship to the AB0 blood type system. METHODS: In a prospective study 34 de novo treated patients were given 2.0 g/kg bodyweight of Privigen and 50 patients received either Privigen [n = 28; 1...
2014: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/23891005/gait-characteristics-of-post-poliomyelitis-patients-standardization-of-quantitative-data-reporting
#15
S Portnoy, I Schwartz
OBJECTIVES: To evaluate the differences in gait characteristics and gait symmetry of post-polio syndrome (PPS) patients ambulating with or without shoes and between subgroups walking with different walking aids and orthoses, study the correlation of these data with personal data, illness condition, physical health, frequency of using aids and orthotics and frequency of falls, and derive recommendations for standardization of reporting these data. METHOD: Twenty-six PPS subjects ambulated with their own walking devices...
October 2013: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/23437995/acceptance-of-pain-in-neurological-disorders-associations-with-functioning-and-psychosocial-well-being
#16
Anna L Kratz, Adam T Hirsh, Dawn M Ehde, Mark P Jensen
OBJECTIVE: Chronic pain acceptance has been shown to be related to positive adjustment to chronic pain in patients presenting with pain as a primary problem. However, the role of pain acceptance in adjustment to chronic pain secondary to a neurological disorder that is often associated with physical disability has not been determined. The purpose of this study was to examine whether two domains of chronic pain acceptance--activity engagement and pain willingness--predict adjustment to pain, controlling for pain intensity and key demographic and clinical variables in individuals with muscular dystrophy (MD), multiple sclerosis (MS), post-polio syndrome (PPS), or spinal cord injury (SCI)...
February 2013: Rehabilitation Psychology
https://www.readbyqxmd.com/read/22776106/intravenous-immunoglobulin-treatment-of-the-post-polio-syndrome-sustained-effects-on-quality-of-life-variables-and-cytokine-expression-after-one-year-follow-up
#17
MULTICENTER STUDY
Henrik Gonzalez, Mohsen Khademi, Kristian Borg, Tomas Olsson
BACKGROUND: Expression of inflammatory cytokines in cerebrospinal fluid (CSF) has led to the hypothesis of intrathecal chronic inflammation to explain the denervation observed in post-polio syndrome (PPS). It has been shown that therapy with intravenous immunoglobulin (IVIG) improves physical performance and dampens down the inflammatory process at 6 months in PPS patients. We here examined the effects of IVIG on cytokine expression and clinical outcome one year after IVIG treatment...
2012: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/22592288/ivig-treatment-in-post-polio-patients-evaluation-of-responders
#18
Gunilla Ostlund, Lisbet Broman, Lars Werhagen, Kristian Borg
The aim of this work is to evaluate the outcome of IVIG treatment in patients with post-polio syndrome (PPS) and to identify responders. The study included 113 PPS patients who had received one IVIG treatment in an open trial, prospective follow-up study. Clinical examination was performed and clinical data were retrieved from medical records. The short form 36 (SF-36), physical activity scale for the elderly (PASE), and the visual analogue scale (VAS) were used as measurements of quality of life, physical activity, and the intensity of pain...
December 2012: Journal of Neurology
https://www.readbyqxmd.com/read/22031351/effect-of-intravenous-immunoglobulin-on-pain-in-patients-with-post-polio-syndrome
#19
Lars Werhagen, Kristian Borg
OBJECTIVE: Pain is a common symptom that affects quality of life in patients with post-polio syndrome. An increase in cytokine in the cerebrospinal fluid suggests that inflammation is pathophysiologically important in post-polio syndrome. Intravenous immunoglobulin might therefore be a therapeutic option. The aim of this study was to analyse the effect of intravenous immunoglobulin treatment on pain in post-polio syndrome. METHODS: An uncontrolled clinical study...
November 2011: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/21687926/post-polio-syndrome-spinal-cord-injury-and-statin-myopathy-double-trouble-or-incorrect-diagnosis-two-case-reports
#20
Lars Werhagen, Kristian Borg
OBJECTIVE: To discuss the importance of a thorough clinical examination and evaluation of symptoms in upper and lower motor neurone lesions. DESIGN: Case report. METHODS: Post-polio outpatient clinic, Danderyds University Hospital, Stockholm, Sweden. We describe here two patients with a past history of poliomyelitis, who were experiencing increasing muscular weakness. Clinical evaluation led to diagnoses of spinal cord injury and statin myopathy, respectively...
July 2011: Journal of Rehabilitation Medicine
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