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https://www.readbyqxmd.com/read/28627767/clinical-significance-of-post-progression-survival-in-lung-cancer
#1
REVIEW
Hisao Imai, Kyoichi Kaira, Koichi Minato
Progression-free survival (PFS) and overall survival (OS) are two common endpoints in cancer trials. OS is usually preferred, because it is reliable, precise, meaningful, and can easily be documented. However, subsequent lines of therapy might confound the effects of first-line treatment on OS. Whether PFS or OS is the more appropriate endpoint in clinical trials of metastatic cancer remains controversial. Previous reports on lung cancer have shown that an increase in PFS does not necessarily result in an increase in OS; however, post-progression survival (PPS) is strongly associated with OS after early-line treatment...
June 19, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28597912/acute-and-long-term-effects-of-brivaracetam-and-brivaracetam-diazepam-combinations-in-an-experimental-model-of-status-epilepticus
#2
Jerome Niquet, Lucie Suchomelova, Kerry Thompson, Henrik Klitgaard, Alain Matagne, Claude Wasterlain
OBJECTIVE: To evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE). METHODS: Rats were treated with BRV (10 mg/kg) 10 min after initiation of perforant path stimulation (PPS) as early treatment; or BRV (10-300 mg/kg), DZP (1 mg/kg), or BRV (0.3-10 mg/kg) + DZP (1 mg/kg) 10 min after the end of PPS (established SSSE). Seizure activity was recorded electrographically for 24 h posttreatment (acute effects), and for 1 week at 6-8 weeks or 12 months' posttreatment (long-term effects)...
June 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28552861/effects-of-pentosan-polysulfate-and-polysulfated-glycosaminoglycan-on-chondrogenesis-of-canine-bone-marrow-derived-mesenchymal-stem-cells-in-alginate-and-micromass-culture
#3
Eugene C Bwalya, Sangho Kim, Jing Fang, H M Suranji Wijekoon, Kenji Hosoya, Masahiro Okumura
Mesenchymal stem cells (MSC) are a potential alternative source of differentiated chondrocytes for cartilage tissue regeneration and repair of osteoarthritic (OA) joints. We investigated the effects of pentosan polysulfate (PPS) and polysulfated glycosaminoglycan (PSGAG) on chondrogenesis of canine bone marrow-derived mesenchymal stem cells (cBMSC) in alginate and micromass cultures (MMC). Chondrogenic differentiation medium (CDM) was supplemented with PPS or PSGAG at concentrations of 0 (positive control; PC), 1, 3 and 5 μg/ml...
May 27, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28506228/chinese-herbal-pulian-ointment-in-treating-psoriasis-vulgaris-of-blood-heat-syndrome-a-multi-center-double-blind-randomized-placebo-controlled-trial
#4
Nuo Li, Wenbin Zhao, Jianmin Xing, Jianping Liu, Guangzhong Zhang, Yunbi Zhang, Yuanwen Li, Wali Liu, Fei Shi, Yanping Bai
BACKGROUND: Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome. METHODS: A multicenter, randomized, double-blind, placebo-controlled trial was conducted. Participants with psoriasis vulgaris of blood-heat syndrome were blinded and randomized to receive Pulian ointment or placebo ointment twice daily for 4 weeks, with follow-up 8 weeks after treatment...
May 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28497614/broad-th2-neutralization-and-anti-inflammatory-action-of-pentosan-polysulfate-sodium-in-experimental-allergic-rhinitis
#5
Caroline Sanden, Michiko Mori, Prajakta Jogdand, Jimmie Jönsson, Ravi Krishnan, Xiangdong Wang, Jonas S Erjefält
BACKGROUND: Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo. METHODOLOGY: The capacity of PPS to bind recombinant Th2 cytokines was tested with surface plasmon resonance (SPR) technology and biological Th2 neutralization was assessed by Th2-dependent proliferation assays...
May 12, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28482405/-efficacy-and-safety-of-pegylated-interferon-%C3%AE-2b-injection-y-shape-40-kd-in-treatment-of-patients-with-genotype-1-6-chronic-hepatitis-c
#6
B Feng, J Shang, S H Wu, H Chen, Y Han, Y Q Li, D Z Zhang, L F Zhao, S F Wei, Q Mao, C B Yin, T Han, M R Wang, S J Chen, J Li, Q Xie, Z Zhen, Z L Gao, Y X Zhang, G Z Gong, D L Yang, C Pan, J F Sheng, H Tang, Q Ning, G F Shi, J Q Niu, G H Luo, Y T Sun, H You, G Q Wang, L L Zhang, J Peng, Q Zhang, J J Liu, C W Chen, X Y Chen, W Zhao, R H Wang, L Sun, L Wei
Objective: To investigate the efficacy and safety of the new investigational drug pegylated interferon α-2b (Peg-IFN-α-2b) (Y shape, 40 kD) injection (180 µg/week) combined with ribavirin in the treatment of patients with genotype 1/6 chronic hepatitis C (CHC), with standard-dose Peg-IFN-α-2a combined with ribavirin as a positive control. Methods: A multicenter, randomized, open-label, and positive-controlled phase III clinical trial was performed. Eligible patients with genotype 1/6 CHC were screened out and randomly divided into Peg-IFN-α-2b(Y shape, 40kD) group and Peg-IFN-α-2a group at a ratio of 2:1...
March 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28479857/meta-analysis-of-the-impact-of-de-novo-and-acquired-egfr-t790m-mutations-on-the-prognosis-of-patients-with-non-small-cell-lung-cancer-receiving-egfr-tkis
#7
Yang Liu, Li Sun, Zhi-Cheng Xiong, Xin Sun, Shu-Ling Zhang, Jie-Tao Ma, Cheng-Bo Han
PURPOSE: The purpose of this meta-analysis was to explore the influences of pretreatment de novo and posttreatment-acquired epidermal growth factor receptor (EGFR) T790M mutations in patients with advanced non-small cell lung cancer (NSCLC) who had received tyrosine kinase inhibitors (TKIs). METHODS: We searched PubMed, Embase, and the China National Knowledge Infrastructure database for eligible literature. Data were extracted to assess the hazard ratios (HRs) for progression-free survival (PFS), overall survival (OS), and post-progression survival (PPS) and the relative ratios (RRs) for objective response rate (ORR)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28475790/prevalence-of-healthcare-associated-infections-and-antimicrobial-use-among-adult-inpatients-in-singapore-acute-care-hospitals-results-from-the-first-national-point-prevalence-survey
#8
Yiying Cai, Indumathi Venkatachalam, Nancy W Tee, Thean Yen Tan, Asok Kurup, Sin Yew Wong, Chian Yong Low, Yang Wang, Winnie Lee, Yi Xin Liew, Brenda Ang, David C Lye, Angela Chow, Moi Lin Ling, Helen M Oh, Cassandra A Cuvin, Say Tat Ooi, Surinder K Pada, Chong Hee Lim, Jack Wei Chieh Tan, Kean Lee Chew, Van Hai Nguyen, Dale A Fisher, Herman Goossens, Andrea L Kwa, Paul A Tambyah, Li Yang Hsu, Kalisvar Marimuthu
Background: We conducted a national point prevalence survey (PPS) to determine the prevalence of healthcare-associated infections (HAIs) and antimicrobial use (AMU) in Singapore acute-care hospitals. Methods: Trained personnel collected HAI, AMU, and baseline hospital- and patient-level data of adult inpatients from 13 private and public acute-care hospitals between July 2015 and February 2016, using the PPS methodology developed by the European Centre for Disease Prevention and Control...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28472120/pentosan-polysulfate-inhibits-il-1%C3%AE-induced-inos-c-jun-and-hif-1%C3%AE-upregulation-in-canine-articular-chondrocytes
#9
Eugene C Bwalya, Sangho Kim, Jing Fang, H M Suranji Wijekoon, Kenji Hosoya, Masahiro Okumura
Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradation. On the other hand, c-Jun N-terminal Kinase (JNK) pathway mediates the activation and transcription of c-Jun, which is required for interleukin-1 (IL-1)-induction of matrix metalloproteinases-13 (MMP-13) in OA pathogenesis. Therefore, the selective inhibition of iNOS and c-Jun is a promising target for treatment and prevention of OA...
2017: PloS One
https://www.readbyqxmd.com/read/28459653/pancreatic-pseudocyst-dilemma-cumulative-multicenter-experience-in-management-using-endoscopy-laparoscopy-and-open-surgery
#10
Alaa A Redwan, Mostafa A Hamad, Mohammed A Omar
BACKGROUND: Pancreatic pseudocyst (PP) is the commonest cystic lesion of the pancreas. Internal drainage of PPs can be accomplished by traditional open or recently by minimally invasive laparoscopic or endoscopic approaches. We aimed to evaluate and compare the clinical outcomes after endoscopic, laparoscopic, and open drainage. METHODS: Seventy-one patients with PP underwent endoscopic (n = 35), laparoscopic (n = 4), and open surgical drainage (n = 32)...
May 1, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28459236/sugarcane-bagasse-dietary-fiber-as-an-adjuvant-therapy-for-stable-chronic-obstructive-pulmonary-disease-a-four-center-randomized-double-blind-placebo-controlled-study
#11
RANDOMIZED CONTROLLED TRIAL
Miao Liu, Fengjie Zheng, Lei Ni, Yan Sun, Ruohan Wu, Tianyu Zhang, Jinchao Zhang, Xianggen Zhong, Yuhang Li
OBJECTIVE: To evaluate the efficacy and safety of sugarcane bagasse dietary fiber as an adjuvant therapy for improving quality of life in patients with stable chronic obstructive pulmonary disease (COPD). METHODS: This was a multicenter, randomized, double-blind, placebo-controlled trial. A total of 196 participants were randomized into a trial group (treated with 6 g/day sugarcane bagasse plus conventional treatment, n = 98) and a control group (treated with placebo plus conventional treatment, n = 98)...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28410978/performance-monitoring-in-nicotine-dependence-considering-integration-of-recent-reinforcement-history
#12
Kevin Butler, Jennifer Rusted, Paul Gard, Anne Jackson
INTRODUCTION: Impaired monitoring of errors and conflict (performance monitoring; PM) is well documented in substance dependence (SD) including nicotine dependence and may contribute to continued drug use. Contemporary models of PM and complementary behavioural evidence suggest that PM works by integrating recent reinforcement history rather than evaluating individual behaviours. Despite this, studies of PM in SD have typically used indices derived from reaction to task error or conflict on individual trials...
April 12, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28410876/the-treatment-of-fatigue-by-non-invasive-brain-stimulation
#13
REVIEW
Jean-Pascal Lefaucheur, Moussa A Chalah, Alaa Mhalla, Ulrich Palm, Samar S Ayache, Veit Mylius
The use of non-invasive brain neurostimulation (NIBS) techniques to treat neurological or psychiatric diseases is currently under development. Fatigue is a commonly observed symptom in the field of potentially treatable pathologies by NIBS, yet very little data has been published regarding its treatment. We conducted a review of the literature until the end of February 2017 to analyze all the studies that reported a clinical assessment of the effects of NIBS techniques on fatigue. We have limited our analysis to repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS)...
April 11, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28398102/relationship-of-depression-and-medications-on-incidence-of-falls-among-people-with-late-effects-of-polio
#14
Carolyn P Da Silva, Bianca Zuckerman, Rhoda Olkin
The purpose of this study was to determine if falls in polio survivors, with or without post-polio syndrome (PPS), are related to number of medications taken, use of anti-depressant or psychoactive medications, or self-report of depression. A survey was sent to 300 members of a regional polio support group, asking them to document their fall history, medications used, and the presence of depression. Depression was measured by self-report and with the Geriatric Depression Scale, short form (GDS-15). One hundred and seventy-two usable surveys were returned with 146 of those completing the medication list...
May 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28390805/from-transmandibular-to-transoral-robotic-approach-for-parapharyngeal-space-tumors
#15
Francesco Chu, Marta Tagliabue, Gioacchino Giugliano, Luca Calabrese, Lorenzo Preda, Mohssen Ansarin
PURPOSE: Parapharyngeal space (PPS) tumors are rare, accounting for 0.5% of all head-and-neck masses. Surgery remains the standard treatment for most cases, including different approaches (cervical approach, parotidectomy, mandibulotomy, transoral/robotic). We report our experience in the management of PPS tumors, aiming to create a surgical algorithm on the base of tumor's radiological and clinical characteristics. MATERIALS AND METHODS: Critical retrospective analysis of patients with PPS neoplasms who underwent surgery at our Institute...
March 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28389419/rationale-and-design-of-khuzestan-vitamin-d-deficiency-screening-program-in-pregnancy-a-stratified-randomized-vitamin-d-supplementation-controlled-trial
#16
Maryam Rostami, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Farhad Hosseinpanah, Hamid Alavi Majd
BACKGROUND: Although there have been marked improvements in our understanding of vitamin D functions in different diseases, gaps on its role during pregnancy remain. Due to the lack of consensus on the most accurate marker of vitamin D deficiency during pregnancy and the optimal level of 25-hydroxyvitamin D, 25(OH)D, for its definition, vitamin D deficiency assessment during pregnancy is a complicated process. Besides, the optimal protocol for treatment of hypovitaminosis D and its effect on maternal and neonatal outcomes are still unclear...
April 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28380484/post-progression-survival-associated-with-overall-survival-in-patients-with-advanced-non-small-cell-lung-cancer-receiving-docetaxel-monotherapy-as-second-line-chemotherapy
#17
Mie Kotake, Yosuke Miura, Hisao Imai, Keita Mori, Reiko Sakurai, Kyoichi Kaira, Yoshio Tomizawa, Koichi Minato, Ryusei Saito, Takeshi Hisada
BACKGROUND: In patients with non-small-cell lung cancer (NSCLC), the effects of second-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies. Therefore, using individual-level data, we aimed to determine the relationships between progression-free survival (PFS) and post-progression survival (PPS) with OS in patients with advanced NSCLC treated with docetaxel monotherapy as second-line chemotherapy. METHODS: Between April 2002 and December 2014, data from 86 patients with advanced NSCLC who underwent second-line docetaxel monotherapy following first-line treatment with platinum combination chemotherapy were analyzed...
2017: Chemotherapy
https://www.readbyqxmd.com/read/28348486/therapeutic-effect-of-curcumin-on-experimental-colitis-mediated-by-inhibiting-cd8-cd11c-cells
#18
Hai-Mei Zhao, Fei Han, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Han-Lin Xu, Duan-Yong Liu
AIM: To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8(+)CD11c(+) cells. METHODS: We evaluated the suppressive effect of Cur on CD8(+)CD11c(+) cells in spleen and Peyer's patches (PPs) in colitis induced by trinitrobenzene sulfonic acid. Mice with colitis were treated by 200 mg/kg Cur for 7 d. On day 8, the therapeutic effect of Cur was evaluated by visual assessment and histological examination, while co-stimulatory molecules of CD8(+)CD11c(+) cells in the spleen and PPs were measured by flow cytometry...
March 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28344441/successful-treatment-of-periodic-paralysis-with-coenzyme-q10-two-case-reports
#19
Yuwei Da, Lin Lei, Karin Jurkat-Rott, Frank Lehmann-Horn
Primary periodic paralyses (PPs) are autosomal dominant ion channel disorders characterized by episodic flaccid weakness associated with variations in serum potassium level. The main prophylactic therapy of choice for PPsis carbonic anhydrase inhibitors that are not always effective. In this report, we described two PP patients who were successfully treated with coenzyme Q10. They remained asymptomatic since initiation of treatment, which may be associated with promotion of energy synthesis, anti-oxidant activity, influence of the fiber type composition and regulation of the expression of gene...
October 2016: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/28279227/treatment-outcomes-of-severe-acute-malnutrition-in-children-treated-within-outpatient-therapeutic-program-otp-at-wolaita-zone-southern-ethiopia-retrospective-cross-sectional-study
#20
Mulugeta Yohannis Kabalo, Canaan Negash Seifu
BACKGROUND: Children in third world countries suffer from severe acute malnutrition (SAM) in an extent of public health important. SAM management protocol available this time brought the approach from facility-based to community-based by Outpatient Therapeutic Program (OTP). But, little was known about the treatment outcomes of the program in Ethiopia. Thus, this study was aimed to assess treatment outcomes of SAM and identify factors associated among children treated at OTP in Wolaita Zone...
March 9, 2017: Journal of Health, Population, and Nutrition
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