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https://www.readbyqxmd.com/read/29887150/clinical-trials
#1
Simon Mead, Fabrizio Tagliavini
Arguably the most important goal of prion research is the discovery of a safe and effective treatment for the human diseases. The final stages of the pathway to develop a treatment require clinical trials. Choices about how a trial is designed and conducted have a large impact on the chances of success. The gold-standard large randomized double-blind placebo-controlled study, which minimizes sources of bias and has been incredibly successful in other diseases, has been hard to achieve in Creutzfeldt-Jakob disease principally because of the rarity and rapidity of the clinical syndrome...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29880850/behaviour-of-aqueous-sulfamethizole-solution-and-temperature-effects-in-cold-plasma-oxidation-treatment
#2
Alexander Sokolov, Marjatta Louhi-Kultanen
The increase in volume and variety of pharmaceuticals found in natural water bodies has become an increasingly serious environmental problem. The implementation of cold plasma technology, specifically gas-phase pulsed corona discharge (PCD), for sulfamethizole abatement was studied in the present work. It was observed that sulfamethizole is easily oxidized by PCD. The flow rate and pH of the solution have no significant effect on the oxidation. Treatment at low pulse repetition frequency is preferable from the energy efficiency point of view but is more time-consuming...
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29877963/crossover-to-bilateral-repetitive-transcranial-magnetic-stimulation-a-potential-strategy-when-patients-are-not-responding-to-unilateral-left-sided-high-frequency-repetitive-transcranial-magnetic-stimulation
#3
Pilar Cristancho, Nicholas T Trapp, Shan H Siddiqi, David Dixon, J Philip Miller, Eric J Lenze
Clinical trials using left-sided repetitive transcranial magnetic stimulation (rTMS) report remission rates of 14% to 32.6%. A large percentage of patients would not achieve remission with standard rTMS treatment. The question of what clinicians should do when a patient is not responding to standard high-frequency (HF) left-sided rTMS remains unanswered. This prospective case series examines whether crossover to bilateral stimulation enhances antidepressant outcomes in patients not responding to unilateral rTMS...
June 5, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29849708/a-randomized-controlled-trial-of-chinese-patent-medicine-xiao-er-biantong-granules-in-the-treatment-of-functional-constipation-in-children
#4
Qiu-Han Cai, Rong Ma, Si-Yuan Hu, Xin-Min Li, Xi-Xiong Xiang, Ying Ding, Ping He, Xin-Min Han, Ke Chang, Wei Zhang, Zheng Xue, Xue-Feng Wang, Cheng-Liang Zhong, Na Yang
Objective: To confirm the effect and safety of Xiao'er Biantong (XEBT) granules for treating chronic constipation in children. Methods: This randomized, double-blind, multicenter study enrolled 480 children with age of 1-14 years who had FC. All of them were randomly assigned to receive either XEBT granules or its placebo in the ratio of 3 : 1. The primary efficacy outcome was the frequency of spontaneous bowel movements (SBM) for 14 days, and secondary outcomes were effectual time, score of main symptoms, effect of constipation, disappearance rate of accompanying symptoms, and recurrence rate...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29845672/sodium-pentosan-polysulfate-efficacy-as-thromboprophylaxis-agent-in-high-risk-women-following-gynecological-surgery
#5
Ima Indirayani, Aida Kalok, Nik A Nik Ismail, Shamsul A Shah, Pei S Lim, Nor A Mohamed Ismail, Abdul G Nur Azurah, Mohd Hashim Omar, Mohamad N Shafiee
AIM: Sodium pentosan polysulfate (Na-PPS) is a plant-based agent that has similar action with low-molecular-weight heparin. It inhibits factor Xa, preventing blood clot formation. To date, its use in clinical practice as thromboprophylaxis agent is still limited. In addition, the efficacy and safety profile of this agent was not robustly reported globally, especially for countries with major Muslim population. We hypothesized that Na-PPS was equally effective as the standard thromboprophylaxis...
May 29, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29766477/-long-term-follow-up-of-psychogenic-pseudosyncope
#6
D P Saal, M J Overdijk, R D Thijs, I M van Vliet, J G van Dijk
BACKGROUND: Patients with psychogenic pseudosyncope (PPS) are frequently seen by neurologists and psychiatrists. As of yet, there has been no follow-up study of patients with PPS after communicating the diagnosis. AIM: To determine the outcome of patients with psychogenic pseudosyncope (PPS) after communicatingthe diagnosis. METHOD: A retrospective cohort study of patients with PPS referred to a tertiary referral center for syncope from 2007 to 2015...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29752826/post-polio-syndrome-and-the-late-effects-of-poliomyelitis-part-2-treatment-management-and-prognosis
#7
REVIEW
Julian K Lo, Lawrence R Robinson
Post-Polio Syndrome (PPS) is characterized by new muscle weakness and/or muscle fatigability that occurs many years following the initial poliomyelitis illness. An individualized approach to rehabilitation management is critical. Interventions may include rehabilitation management strategies, adaptive equipment, orthotic equipment, gait/mobility aids and a variety of therapeutic exercises. The progression of muscle weakness in PPS is typically slow and gradual; however, there is also variability in both the natural history of weakness and functional prognosis...
May 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29745734/primary-prevention-of-post-pericardiotomy-syndrome-using-corticosteroids-a-systematic-review
#8
Rachel Wamboldt, Gianluigi Bisleri, Benedict Glover, Sohaib Haseeb, Gary Tse, Tong Liu, Adrian Baranchuk
Post-pericardiotomy syndrome is a well-recognized inflammatory phenomenon that commonly occurs in patients following cardiac surgery. Due to the increased morbidity and resource utilization associated with this condition, research has recently focused on ways of preventing its prevention this condition; primarily using colchicine, NSAIDs and corticosteroids. Areas covered: This systematic review summarizes the three clinical studies that have used corticosteroids for PPS primary prevention in the perioperative period...
June 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29723866/prognostic-factors-associated-with-postprogression-survival-in-advanced-hepatocellular-carcinoma-patients-treated-with-sorafenib-not-eligible-for-second-line-regorafenib-treatment
#9
Teiji Kuzuya, Masatoshi Ishigami, Yoji Ishizu, Takashi Honda, Kazuhiko Hayashi, Tetsuya Ishikawa, Isao Nakano, Yoshiki Hirooka, Hidemi Goto
OBJECTIVES: The aim of this study was to investigate the prognostic factors associated with postprogression survival (PPS) in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib, who were not eligible for second-line treatment with regorafenib. METHODS: A total of 103 patients with radiological confirmation of progressive disease (PD) were enrolled. RESULTS: The median PPS (n = 67) was 6.1 months. Significant and independent prognostic factors at initial radiological PD associated with good PPS were an Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score of 0, the absence of macrovascular invasion (MVI), and time to progression (TTP) ≥4 months...
May 3, 2018: Oncology
https://www.readbyqxmd.com/read/29710214/association-between-hearing-aid-use-and-health-care-use-and-cost-among-older-adults-with-hearing-loss
#10
Elham Mahmoudi, Philip Zazove, Michelle Meade, Michael M McKee
Importance: Hearing loss (HL) is common among older adults and is associated with poorer health and impeded communication. Hearing aids (HAs), while helpful in addressing some of the outcomes of HL, are not covered by Medicare. Objective: To determine whether HA use is associated with health care costs and utilization in older adults. Design, Setting, and Participants: This retrospective cohort study used nationally representative 2013-2014 Medical Expenditure Panel Survey data to evaluate the use of HAs among 1336 adults aged 65 years or older with HL...
April 26, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29703486/updated-clinical-models-for-vte-prediction-in-hospitalized-medical-patients
#11
Grigoris T Gerotziafas, Loula Papageorgiou, Stella Salta, Katerina Nikolopoulou, Ismail Elalamy
Venous thromboembolism (VTE) occurring in hospitalized medical patients is associated with increased length of hospitalization, high rate of acute care hospital transfer, longer inpatient rehabilitation and multiplication of health-care costs. Identification of acutely ill hospitalized medical patients eligible for thromboprophylaxis is a sophisticated process. Global VTE risk stems from the combination of predictors related with the acute medical illness, comorbidities, associated treatments and patients' intrinsic risk factors...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29690946/longitudinal-point-prevalence-survey-of-antibacterial-use-in-northern-ireland-using-the-european-surveillance-of-antimicrobial-consumption-esac-pps-and-global-pps-tool
#12
G M Al-Taani, M Scott, D Farren, F Gilmore, B Mccullagh, C Hibberd, A Mccorry, A Versporten, H Goossens, P Zarb, M A Aldeyab
Antimicrobial resistance is a limiting factor for the success of the treatment of infectious diseases and is associated with increased morbidity and cost. The present study aims to evaluate prescribing patterns of antimicrobials and quantify progress in relation to targets for quality improvement in the prescription of antimicrobials in Northern Ireland's secondary care sector using three repetitive point prevalence surveys (PPS) over a 6-year period: the European Surveillance of Antimicrobial Consumption (ESAC-PPS) in 2009 and 2011 and the Global-PPS on Antimicrobial Consumption and Resistance in 2015...
April 25, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29682625/review-of-management-options-for-pancreatic-pseudocysts
#13
REVIEW
Christos Agalianos, Ioannis Passas, Ioannis Sideris, Demetrios Davides, Christos Dervenis
Pancreatic pseudocysts (PPs) present a challenging problem for physicians dealing with pancreatic disorders. Their management demands the co-operation of surgeons, radiologists and gastroenterologists. Historically, they have been treated either conservatively or surgically, with acceptable rates of complications and recurrence. However, recent advances in radiology and endoscopy, have leaded physicians to implement percutaneous and endoscopic drainage (ED) into their treatment algorithms. Moreover, laparoscopic surgery, with its advantages, has become an attractive alternative choice when surgical drainage (SD) is required...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29681513/antimicrobial-consumption-and-resistance-in-adult-hospital-inpatients-in-53-countries-results-of-an-internet-based-global-point-prevalence-survey
#14
Ann Versporten, Peter Zarb, Isabelle Caniaux, Marie-Françoise Gros, Nico Drapier, Mark Miller, Vincent Jarlier, Dilip Nathwani, Herman Goossens
BACKGROUND: The Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed to assess antimicrobial prescribing and resistance in hospital inpatients. METHODS: We used a standardised surveillance method to collect detailed data about antimicrobial prescribing and resistance from hospitals worldwide, which were grouped by UN region. The internet-based survey included all inpatients (adults, children, and neonates) receiving an antimicrobial who were on the ward at 0800 h on one specific day between January and September, 2015...
June 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29676139/-effect-of-xinling-wan-in-treatment-of-stable-angina-pectoris-a-randomized-double-blinded-placebo-parallel-controlled-multicenter-trial
#15
Jian-Wei Gao, Xue-Min Gao, Ting Zou, Tian-Meng Zhao, Dong-Hua Wang, Zong-Gui Wu, Chang-Jie Ren, Xing Wang, Nai-Zhi Geng, Ming-Jun Zhao, Qiu-Ming Liang, Xing Feng, Bai-Song Yang, Jun-Ling Shi, Qi Hua
To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris, a randomized, double-blinded, placebo parallel-controlled, multicenter clinical trial was conducted. A total of 232 subjects were enrolled and randomly divided into experiment group and placebo group. The experiment group was treated with Xinling Wan (two pills each time, three times daily) for 4 weeks, and the placebo group was treated with placebo. The effectiveness evaluation showed that Xinling Wan could significantly increase the total duration of treadmill exercise among patients with stable angina pectoris...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29597147/caffeic-acid-phenethyl-ester-down-regulates-claudin-2-expression-at-the-transcriptional-and-post-translational-levels-and-enhances-chemosensitivity-to-doxorubicin-in-lung-adenocarcinoma-a549-cells
#16
Hiroyuki Sonoki, Asami Tanimae, Takumi Furuta, Satoshi Endo, Toshiyuki Matsunaga, Kenji Ichihara, Akira Ikari
Claudin-2 is highly expressed in human lung adenocarcinoma cells and involved in the promotion of proliferation. Here, we searched for a compound, which can decrease claudin-2 expression using lung adenocarcinoma A549 cells. In the screening using compounds included in royal jelly and propolis, the protein level of claudin-2 was dose-dependently decreased by caffeic acid phenethyl ester (CAPE), whereas the mRNA level and promoter activity were only decreased by 50 μM CAPE. These results suggest that CAPE down-regulates claudin-2 expression mediated by two different mechanisms...
June 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29581765/overall-survival-and-post-progression-survival-are-potent-endpoint-in-phase-iii-trials-of-second-third-line-chemotherapy-for-advanced-or-recurrent-epithelial-ovarian-cancer
#17
Mototsugu Shimokawa, Takahiro Kogawa, Takako Shimada, Toshiaki Saito, Hozumi Kumagai, Masafumi Ohki, Tsunehisa Kaku
Purpose: A growing number of treatment options and active compounds in treatments have led to better outcomes for patients with advanced or recurrent epithelial ovarian cancer. We examined the association between progression-free survival (PFS), post-progression survival (PPS) and overall survival (OS) in phase III trials of second- and third-line chemotherapy for advanced or recurrent epithelial ovarian cancer. We aim to determine whether PFS or PPS is a surrogate of OS so that we can decide progress of disease is optimal endpoint for ovarian cancer...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29579425/knowledge-of-private-practitioners-of-bangalore-city-in-diagnosis-treatment-of-pulmonary-tuberculosis-and-compliance-with-case-notification
#18
Bhoomika Bajaj Bhalla, V K Chadha, J Gupta, N Nagendra, P Praseeja, S M Anjinappa, J Ahmed, R K Srivastava, P Kumar
One hundred and twenty-nine qualified private practitioners (PPs) were assessed on their knowledge in diagnosis of pulmonary tuberculosis (PTB), treatment of a new drug sensitive PTB case and practices of case notification, using semi-structured questionnaire. About 20% had adequate knowledge of diagnosis, 29% of treatment regimen, 54% the need for Direct Observation Treatment and 57% about role of sputum smear examination in monitoring treatment response. Of 85 (68%) PPs who had diagnosed any TB case during last two years, 54 (64%) had practised notification...
April 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29575167/empirical-treatment-of-outpatients-with-gastroesophageal-reflux-disease-with-proton-pump-inhibitors-a-survey-of-chinese-patients-the-enlight-study
#19
Bin Lu, Ling Zhang, Jiangbin Wang, Bangmao Wang, Xiaoping Zou, Guijun Fei, Dongfeng Chen, Xuehong Wang, Bin Wu, Duowu Zou
BACKGROUND AND AIM: Empirical proton pump inhibitor (PPI) treatment is recommended as a diagnostic indicator for gastroesophageal reflux disease (GERD) and as a therapy for symptomatic control, with responses generally seen within 4 weeks. However, there are no real-world data assessing the effectiveness of short-term empirical treatment with PPIs in patients with GERD in China. METHODS: The ENLIGHT study was a multicenter, prospective, observational study conducted in China...
March 25, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29549858/a-hybrid-bioreactor-based-on-insolubilized-tyrosinase-and-laccase-catalysis-and-microfiltration-membrane-remove-pharmaceuticals-from-wastewater
#20
Sidy Ba, Lounès Haroune, Lassine Soumano, Jean-Phillipe Bellenger, J Peter Jones, Hubert Cabana
The increasing presence of pharmaceutical products (PPs) and other organic contaminants of emerging concern (CECs) in aquatic systems has become one of the major global environmental contamination concerns. Sewage treatment plants (STPs) are one of the major sources of PPs discharge into natural waters due to the deficiencies of conventional treatment processes to deal with these micropollutants. Numerous new treatment processes and technologies have been investigated for the removals of CECs in wastewaters with more or less success...
June 2018: Chemosphere
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