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https://www.readbyqxmd.com/read/29597147/caffeic-acid-phenethyl-ester-down-regulates-claudin-2-expression-at-the-transcriptional-and-post-translational-levels-and-enhances-chemosensitivity-to-doxorubicin-in-lung-adenocarcinoma-a549-cells
#1
Hiroyuki Sonoki, Asami Tanimae, Takumi Furuta, Satoshi Endo, Toshiyuki Matsunaga, Kenji Ichihara, Akira Ikari
Claudin-2 is highly expressed in human lung adenocarcinoma cells and involved in the promotion of proliferation. Here, we searched for a compound, which can decrease claudin-2 expression using lung adenocarcinoma A549 cells. In the screening using compounds included in royal jelly and propolis, the protein level of claudin-2 was dose-dependently decreased by caffeic acid phenethyl ester (CAPE), whereas the mRNA level and promoter activity were only decreased by 50 μM CAPE. These results suggest that CAPE down-regulates claudin-2 expression mediated by two different mechanisms...
March 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29581765/overall-survival-and-post-progression-survival-are-potent-endpoint-in-phase-iii-trials-of-second-third-line-chemotherapy-for-advanced-or-recurrent-epithelial-ovarian-cancer
#2
Mototsugu Shimokawa, Takahiro Kogawa, Takako Shimada, Toshiaki Saito, Hozumi Kumagai, Masafumi Ohki, Tsunehisa Kaku
Purpose: A growing number of treatment options and active compounds in treatments have led to better outcomes for patients with advanced or recurrent epithelial ovarian cancer. We examined the association between progression-free survival (PFS), post-progression survival (PPS) and overall survival (OS) in phase III trials of second- and third-line chemotherapy for advanced or recurrent epithelial ovarian cancer. We aim to determine whether PFS or PPS is a surrogate of OS so that we can decide progress of disease is optimal endpoint for ovarian cancer...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29579425/knowledge-of-private-practitioners-of-bangalore-city-in-diagnosis-treatment-of-pulmonary-tuberculosis-and-compliance-with-case-notification
#3
Bhoomika Bajaj Bhalla, V K Chadha, J Gupta, N Nagendra, P Praseeja, S M Anjinappa, J Ahmed, R K Srivastava, P Kumar
One hundred and twenty-nine qualified private practitioners (PPs) were assessed on their knowledge in diagnosis of pulmonary tuberculosis (PTB), treatment of a new drug sensitive PTB case and practices of case notification, using semi-structured questionnaire. About 20% had adequate knowledge of diagnosis, 29% of treatment regimen, 54% the need for Direct Observation Treatment and 57% about role of sputum smear examination in monitoring treatment response. Of 85 (68%) PPs who had diagnosed any TB case during last two years, 54 (64%) had practised notification...
April 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29575167/empirical-treatment-of-outpatients-with-gastroesophageal-reflux-disease-with-proton-pump-inhibitors-a-survey-of-chinese-patients-the-enlight-study
#4
Bin Lu, Ling Zhang, Jiangbin Wang, Bangmao Wang, Xiaoping Zou, Guijun Fei, Dongfeng Chen, Xuehong Wang, Bin Wu, Duowu Zou
BACKGROUND: Empirical proton pump inhibitor (PPI) treatment is recommended as a diagnostic indicator for GERD and as a therapy for symptomatic control, with responses generally seen within 4 weeks. However, there are no real-world data assessing the effectiveness of short-term empirical treatment with PPIs in patients with GERD in China. METHODS: The ENLIGHT study was a multicenter, prospective, observational study conducted in China. The primary outcome was the overall response rate after 4 weeks' empirical treatment with PPIs...
March 25, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29549858/a-hybrid-bioreactor-based-on-insolubilized-tyrosinase-and-laccase-catalysis-and-microfiltration-membrane-remove-pharmaceuticals-from-wastewater
#5
Sidy Ba, Lounès Haroune, Lassine Soumano, Jean-Phillipe Bellenger, J Peter Jones, Hubert Cabana
The increasing presence of pharmaceutical products (PPs) and other organic contaminants of emerging concern (CECs) in aquatic systems has become one of the major global environmental contamination concerns. Sewage treatment plants (STPs) are one of the major sources of PPs discharge into natural waters due to the deficiencies of conventional treatment processes to deal with these micropollutants. Numerous new treatment processes and technologies have been investigated for the removals of CECs in wastewaters with more or less success...
March 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29540336/a-randomized-double-blind-controlled-multi-center-study-of-ilaparazole-in-the-treatment-of-reflux-esophagitis-phase-iii-clinical-trial
#6
Yan Xue, Xianghong Qin, Liya Zhou, Sanren Lin, Ling Wang, Haitang Hu, Jielai Xia
AIM AND BACKGROUND: Proton pump inhibitors (PPIs) are the main drugs for the treatment of reflux esophagitis. Phase II clinical trials showed that, compared with Esomeprazole, the new PPI Ilaparazole is great in terms of efficacy for reflux symptoms relief and curling for esophagitis. The aim of this study was to confirm suitable dose of Ilaparazole in the treatment of reflux esophagitis. METHODS: This study used a randomized, double-blind, parallel positive drug control, multi-center design...
March 11, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29519327/surgical-management-of-pancreatic-pseudocysts
#7
REVIEW
Lea Matsuoka, Sophoclis P Alexopoulos
Open surgical intervention for treatment of simple pancreatic pseuodocyst (PP) has a high success rate and has been the historical gold standard. Open surgical intervention, however, confers significant morbidity and mortality, which has spurred the development of less invasive techniques. Laparoscopic approaches are feasible with the potential for lower complication rates and length of stay. The endoscopic approach has the appeal of potentially shorter hospitalization length of stays and does not require general anesthesia...
April 2018: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/29508094/the-effect-of-post-progression-survival-on-overall-survival-among-patients-with-sensitive-relapse-of-small-cell-lung-cancer
#8
Yosuke Miura, Hisao Imai, Reiko Sakurai, Kyoichi Kaira, Noriaki Sunaga, Koichi Minato, Ryusei Saito, Takeshi Hisada
Recent studies have suggested that, among patients with advanced lung cancer, subsequent treatment after failure of first-line or second-line chemotherapy has a greater effect on overall survival (OS) than tumor shrinkage or progression-free survival (PFS). However, no studies have examined this issue among patients with sensitive relapse of small cell lung cancer (SCLC). We retrospectively evaluate 77 patients with sensitive relapse of SCLC who received second-line chemotherapy after first-line platinum doublet chemotherapy between January 1999 and November 2013...
March 5, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29506301/-beneficial-effect-of-medical-cannabis-in-the-treatment-of-a-pharmacoresistant-nausea-associated-with-a-somatoform-disorder-in-a-patient-with-post-polio-syndrome
#9
Markus Bleckwenn, Klaus Weckbecker, Sebastian Voss
HISTORY AND CLINICAL FINDINGS:  We report a 79-year-old patient with post-polio syndrome (PPS). In the course of this disease, recurrent upper abdominal pain and a therapy-resistant nausea developed without vomiting. In addition, the patient was limited by the combination of muscular weakness, obesity, dietary-treated diabetes and a degenerative spinal cord injury significantly in its mobility and physical capacity. INVESTIGATIONS AND DIAGNOSIS:  Despite extensive diagnostics, no somatic cause could be found neither for the nausea nor for the upper abdominal pain...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29487444/plastein-reaction-enhanced-bile-acid-binding-capacity-of-soybean-protein-hydrolysates-and-whey-protein-hydrolysates
#10
Fang Qian, Ying Wang, Zi-Jian Wen, Shu-Juan Jiang, Yan-Feng Tuo, Guang-Qing Mu
Plastein reaction is a modification reaction that can improve the functional properties of protein hydrolysate. The product of the reaction is a thixotropic aggregation of peptides. This study investigated the formation condition of soybean-whey plastein and bile acid binding capacity of plastein. Soy protein and whey protein were hydrolyzed by pepsin. The mixture (1:1, w/w) of two hydrolysates was modified by pepsin again. After the reaction, the decrease in free amino groups and the turbidity of the modified hydrolysate were measured to obtain appropriate reaction condition...
March 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29468812/modulation-of-schlemm-s-canal-endothelial-cell-stiffness-via-latrunculin-loaded-block-copolymer-micelles
#11
Trevor Stack, Amir Vahabikashi, Mark Johnson, Evan Scott
Increased stiffness of Schlemm's canal endothelial cells (SC cells) is a major contributing factor to the increased pressure characteristic of primary open-angle glaucoma. New treatments for glaucoma are being developed using actin depolymerizers and rho kinase inhibitors to address this increased stiffness. However, these agents have off-target effects and are not as potent as had been hoped. We have developed a micellar nanocarrier assembled from poly(ethylene glycol)-bl-poly(propylene sulfide) copolymers capable of encapsulating latrunculin A (Lat A) with the goal of modulating SC cell stiffness...
February 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29466864/quality-of-life-in-a-hospice-a-validation-of-the-croatian-version-of-the-eortc-qlq-c15-pal
#12
Marin Golčić, Renata Dobrila-Dintinjana, Goran Golčić, Ira Pavlović-Ružić, Aleksandra Stevanović, Lidija Gović-Golčić
PURPOSE: Quality of life is the cornerstone of palliative care, and assessing it requires validated and standardized questionnaires. However, the majority of questionnaires are not tested in a hospice setting. The purpose of this study is to evaluate the quality of life in a hospice using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care (PAL) (EORTC QLQ-C15-PAL) questionnaire and validating it in Croatian language...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29465065/can-ecdc-pps-hai-au-data-on-antimicrobial-use-can-be-used-to-evaluate-adherence-to-national-guidelines-for-antimicrobial-treatment-of-community-acquired-pneumonia
#13
Aleksander Deptuła, Ewa Trejnowska, Grzegorz Dubiel, Maria Deptuła, Marleta Zienkiewicz, Agnieszka Żukowska, Agnieszka Misiewska-Kaczur, Tomasz Ozorowski, Piotr Księżniakiewicz, Joanna Kubiak, Waleria Hryniewicz
INTRODUCTION Point-prevalence surveys are widely described as a useful tool for evaluation of antimicrobial policy, as well as adherence to the guidelines. OBJECTIVES To evaluate if ECDC Point Prevalence Survey and Antimicrobial Use (PPS HAI&AU) data can be used for evaluation of adherence to the national guidelines (NG) for the treatment of community-acquired pneumonia (CAP) and analysis of the quality of treatment regimens. PATIENTS AND METHODS Data for 72 698 patients were collected in Poland between 2012-2015 according to the ECDC Protocol v...
February 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29429842/trabectedin-in-ovarian-cancer-is-it-now-a-standard-of-care
#14
J Ventriglia, I Paciolla, S C Cecere, C Pisano, M Di Napoli, L Arenare, S V Setola, N S Losito, D Califano, M Orditura, S Pignata
In patients with recurrent ovarian cancer, the choice of second-line therapy is complex. Several factors have to be considered, such as platinum-free interval (PFI), residual toxicity from the previous treatments, BRCA1/2 gene mutation status. Trebectedin is a minor groove DNA binder derived from a marine organism that has shown efficacy in different settings in ovarian cancer therapy. It has been approved in the treatment of partially platinum sensitive (PPS) (PFI between 6 and 12 months) relapsed ovarian cancer according to the statistically significant progression-free survival (7...
February 8, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29417279/tumors-of-the-parapharyngeal-space-the-vu-university-medical-center-experience-over-a-20-year-period
#15
Thijs van Hees, Stijn van Weert, Birgit Witte, C René Leemans
BACKGROUND: Tumors of the parapharyngeal space (PPS) are rare, accounting for 0.5-1.5% of all head and neck tumors. The anatomy of the PPS is responsible for a wide variety of tumors arising from the PPS. This series of 99 PPS tumors provides an overview of the clinical course and management of PPS tumors. MATERIALS AND METHODS: This retrospective study included clinical data from patients treated for PPS tumors from 1991 to 2012 (warranting at least a 4-year follow-up) at the VU University Medical Center, Amsterdam, The Netherlands...
February 7, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29395473/application-of-radiopaque-micro-particle-fillers-for-3-d-imaging-of-periodontal-pocket-analogues-using-cone-beam-ct
#16
M Elashiry, M M Meghil, S Kalathingal, A Buchanan, R Elrefai, S Looney, M Rajendran, M Ochieng, N Young, A Elawady, R M Arce, K H Sandhage, C W Cutler
BACKGROUND: Periodontitis is an infectious/inflammatory disease most often diagnosed by deepening of the gingival sulcus, which leads to periodontal pockets (PPs) conventional manual periodontal probing does not provide detailed information on the three-dimensional (3-D) nature of PPs. OBJECTIVES: To determine whether accurate 3-D analyses of the depths and volumes of calibrated PP analogues (PPAs) can be obtained by conventional cone beam computed tomography (CBCT) coupled with novel radiopaque micro-particle fillers (described in the companion paper) injected into the PPAs...
April 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29394580/-treatment-out-come-of-eribulin-in-patients-with-advanced-or-metastatic-breast-cancer-who-resistant-to-anthracycline-and-taxane
#17
Natsuko Tanaka, Kaoru Ogura, Akinori Hattori, Hiroaki Inoue, Hiroko Yukawa, Shiho Sakaguchi, Aya Matsuoka, Asaka Kodera, Yoshihiko Naritaka, Akira Hirano
PATIENTS AND METHODS: This retrospective observational study contains advanced or metastatic breast cancer female patients who pretreated with anthracycline and/or taxane received eribulin(ERI)mesylate. The primary endpoint was the progressionfree survival(PFS)and secondary endopoints were objective response rate(ORR), clinical benefit rate(CBR), overall survival (OS), and post-progression survival(PPS). RESULTS: A total of 32 patients underwent chemotherapy cycles(median 3; range 1-9 cycles)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29336057/amelioration-of-colitis-through-blocking-lymphocytes-entry-to-peyer-s-patches-by-sphingosine-1-phosphate-lyase-inhibitor
#18
Kazuhiko Shirakabe, Masaaki Higashiyama, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Masayuki Saruta, Ryota Hokari
BACKGROUND AND AIM: Sphingosine-1-phosphate (S1P) receptor 1, a therapeutic target of the S1P1 agonist FTY720, plays a crucial role in lymphocyte migration and is expressed in several cells including naïve T lymphocytes and endothelial cells. 2-Acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase, exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear. This study aimed to clarify how THI affects colitis and migration of naïve T lymphocytes in Peyer's patches (PPs)...
January 15, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29335909/persistent-posterior-seroma-after-laparoscopic-repair-of-ventral-abdominal-wall-hernias-with-expanded-polytetrafluoroethylene-mesh-prevalence-independent-predictors-and-detached-tacks-retrospective-review
#19
V M A Stirler, R J de Haas, J T F J Raymakers, S Rakic
PURPOSE: A persistent seroma located posterior to a mesh (PPS) remains a little known complication after laparoscopic ventral hernia repair (LVHR). The aim of this large case series was to analyse the prevalence and clinical course as well as identify related factors and independent predictors of PPS. METHODS: All 1288 adult patients who underwent a LVHR with an expanded polytetrafluoroethylene mesh (ePTFE) between January 2003 and July 2014 were reviewed. Those who underwent an abdominal computed tomography (CT) scan more than 3 months afterwards (n = 166) were included and their scans were analysed...
April 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29305302/actual-state-of-knowledge-in-the-field-of-diseases-related-with-defective-nucleotide-excision-repair
#20
REVIEW
Barbara Bukowska, Bolesław T Karwowski
Xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome (CS) are rare genetic diseases characterized by a large range of clinical symptoms. However, they are all associated with defects in nucleotide excision repair (NER), the system responsible for removing bulky DNA lesions such as those generated by UV light: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone photoproducts (6-4 PPs). Over the past years, detailed structural and biochemical information on NER-associated proteins has emerged...
February 15, 2018: Life Sciences
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