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https://www.readbyqxmd.com/read/27919456/risk-factors-and-prognosis-of-postpericardiotomy-syndrome-in-patients-undergoing-valve-surgery
#1
Dirk van Osch, Jan M Dieleman, Jeroen J Bunge, Diederik van Dijk, Pieter A Doevendans, Willem J Suyker, Hendrik M Nathoe
OBJECTIVE: The study aim was to investigate the long-term prognosis and risk factors of postpericardiotomy syndrome (PPS). METHODS: We performed a single-center cohort study in 822 patients undergoing nonemergent valve surgery. Risk factors of PPS were evaluated using multivariable logistic regression analysis. We also compared the incidence of reoperation for tamponade at 1 year between patients with and without PPS. Main secondary outcomes were hospital stay and mortality...
November 15, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27896891/stat3-targeting-by-polyphenols-novel-therapeutic-strategy-for-melanoma
#2
REVIEW
Saeideh Momtaz, Kamal Niaz, Faheem Maqbool, Mohammad Abdollahi, Luca Rastrelli, Seyed Mohammad Nabavi
Melanoma or malignant melanocytes appear with the low incidence rate, but very high mortality rate worldwide. Epidemiological studies suggest that polyphenolic compounds contribute for prevention or treatment of several cancers particularly melanoma. Such findings motivate to dig out novel therapeutic strategies against melanoma, including research toward the development of new chemotherapeutic and biologic agents that can target the tumor cells by different mechanisms. Recently, it has been found that signal transducer and activator of transcription 3 (STAT3) is activated in many cancer cases surprisingly...
November 29, 2016: BioFactors
https://www.readbyqxmd.com/read/27871265/the-association-between-different-opioid-doses-and-the-survival-of-advanced-cancer-patients-receiving-palliative-care
#3
Anon Sathornviriyapong, Kittiphon Nagaviroj, Thunyarat Anothaisintawee
BACKGROUND: Concerns that opioids may hasten death can be a cause of the physicians' reluctance to prescribe opioids, leading to inadequate symptom palliation. Our aim was to find if there was an association between different opioid doses and the survival of the cancer patients that participated in our palliative care program. METHODS: A retrospective study was conducted at Ramathibodi Hospital, Bangkok between January 2013 and December 2015. All of the cancer patients that were referred to palliative care teams by their primary physicians were included in the study...
November 21, 2016: BMC Palliative Care
https://www.readbyqxmd.com/read/27859557/estimation-of-conditional-and-marginal-odds-ratios-using-the-prognostic-score
#4
David Hajage, Yann De Rycke, Guillaume Chauvet, Florence Tubach
Introduced by Hansen in 2008, the prognostic score (PGS) has been presented as 'the prognostic analogue of the propensity score' (PPS). PPS-based methods are intended to estimate marginal effects. Most previous studies evaluated the performance of existing PGS-based methods (adjustment, stratification and matching using the PGS) in situations in which the theoretical conditional and marginal effects are equal (i.e., collapsible situations). To support the use of PGS framework as an alternative to the PPS framework, applied researchers must have reliable information about the type of treatment effect estimated by each method...
November 17, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27857020/surrogate-endpoints-in-second-line-trials-of-targeted-agents-in-metastatic-colorectal-cancer-a-literature-based-systematic-review-and-meta-analysis
#5
Chiara Cremolini, Carlotta Antoniotti, Filippo Pietrantonio, Rosa Berenato, Marco Tampellini, Chiara Baratelli, Lisa Salvatore, Federica Marmorino, Beatrice Borelli, Federico Nichetti, Paolo Bironzo, Cristina Sonetto, Maria Di Bartolomeo, Filippo de Braud, Fotios Loupakis, Alfredo Falcone, Massimo Di Maio
Purpose: To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints of overall survival (OS) in modern clinical trials investigating the efficacy of targeted agents in the second-line treatment of metastatic colorectal cancer (mCRC). Materials and Methods: A systematic search of literature pertaining to randomized phase II and III trials evaluating targeted agents as second-line treatments for mCRC was performed. The strength of the correlation between both PFS and ORR and OS was assessed based on the Pearson's correlation coefficient (R) and the coefficient of determination (R2)...
November 15, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27855343/removing-heavy-metals-using-permeable-pavement-system-with-a-titanate-nano-fibrous-adsorbent-column-as-a-post-treatment
#6
Danious Pratheep Sounthararajah, Paripurnanda Loganathan, Jayakumar Kandasamy, Saravanamuthu Vigneswaran
Permeable pavement systems (PPS) are a widely-used treatment measure in sustainable stormwater management and groundwater recharge. However, PPS are not very efficient in removing heavy metals from stormwater. A pilot scale study using zeolite or basalt as bed material in PPS removed 41-72%, 67-74%, 38-43%, 61-72%, 63-73% of Cd, Cu, Ni, Pb, and Zn, respectively, from synthetic stormwater (pH 6.5; Cd, Cu, Ni, Pb, and Zn concentrations of 0.04, 0.6, 0.06, 1.0, and 2.0 mg L(-1), respectively) over a period of 80 h...
November 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27829033/outcomes-of-nigeria-s-hiv-aids-treatment-program-for-patients-initiated-on-antiretroviral-treatment-between-2004-2012
#7
Ibrahim Dalhatu, Dennis Onotu, Solomon Odafe, Oseni Abiri, Henry Debem, Simon Agolory, Ray W Shiraishi, Andrew F Auld, Mahesh Swaminathan, Kainne Dokubo, Evelyn Ngige, Chukwuemeka Asadu, Emmanuel Abatta, Tedd V Ellerbrock
BACKGROUND: The Nigerian Antiretroviral therapy (ART) program started in 2004 and now ranks among the largest in Africa. However, nationally representative data on outcomes have not been reported. METHODS: We evaluated retrospective cohort data from a nationally representative sample of adults aged ≥15 years who initiated ART during 2004 to 2012. Data were abstracted from 3,496 patient records at 35 sites selected using probability-proportional-to-size (PPS) sampling...
2016: PloS One
https://www.readbyqxmd.com/read/27799882/narrow-band-imaging-with-magnifying-endoscopy-for-peyer-s-patches-is-useful-in-predicting-the-recurrence-of-remissive-patients-with-ulcerative-colitis
#8
Satoshi Hiyama, Hideki Iijima, Syoichiro Kawai, Akira Mukai, Eri Shiraishi, Shuko Iwatani, Toshio Yamaguchi, Manabu Araki, Yoshito Hayashi, Shinichiro Shinzaki, Tsunekazu Mizushima, Masahiko Tsujii, Tetsuo Takehara
BACKGROUND/AIMS: Peyer's patches (PPs) are aggregates of lymphoid follicles that are mainly located in the distal ileum; they play a major role in mucosal immunity. We recently reported that patients with ulcerative colitis (UC) have alterations in PPs that can be detected using narrow-band imaging with magnifying endoscopy (NBI-ME). However, the usefulness of NBI-ME in UC treatment as a whole is still unknown. METHODS: We collected NBI-ME images of PPs from 67 UC patients who had undergone ileocolonoscopy...
October 2016: Intestinal Research
https://www.readbyqxmd.com/read/27794459/plant-polysaccharides-used-as-immunostimulants-enhance-innate-immune-response-and-disease-resistance-against-aeromonas-hydrophila-infection-in-fish
#9
Erlong Wang, Xia Chen, Kaiyu Wang, Jun Wang, Defang Chen, Yi Geng, Weimin Lai, Xianchao Wei
Plant polysaccharides (PPS) are an important medicinal plant product, and play a major role in preventing and controlling infectious microbes in aquaculture. The present study investigated the effect of three PPS; Ficus carica polysaccharides (FCPS), Radix isatidis polysaccharides (RIPS), and Schisandra chinensis polysaccharides (SCPS), used as feed additives, on innate immune responses and disease resistance against Aeromonas hydrophila in crucian carp. Results show that crucian carp fed with these PPS showed significant (p < 0...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27793017/therapeutic-effect-of-apatinib-on-overall-survival-is-mediated-by-prolonged-progression-free-survival-in-advanced-gastric-cancer-patients
#10
Lihong Huang, Yongyue Wei, Sipeng Shen, Qianwen Shi, Jianling Bai, Jin Li, Shukui Qin, Hao Yu, Feng Chen
Apatinib is reported to significantly improve the overall survival (OS) of patients with advanced gastric cancer who have previously failed second-line chemotherapy. However, it is not well understood whether apatinib acts by improving progression or by prolonging post-progression survival. Here, based on phase III clinical trial data, the mediating effect of apatinib on patient overall survival was systematically quantified, through progression-free survival (PFS), post-progression survival (PPS), and the disease control rate (DCR)...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27761786/post-pericardiotomy-syndrome
#11
Balaji K Tamarappoo, Allan L Klein
Post-pericardiotomy syndrome (PPS) occurs in a subgroup of patients who have undergone cardiothoracic surgery and is characterized by fever, pleuritic pain, pleural effusion, and pericardial effusion. It is associated with significant morbidity, and the leading complications include tamponade and constrictive pericarditis. Epidemiologic studies have found that PPS often occurs among younger patients; however, there is a lack of comprehensive risk stratification. It is therefore important to be able to identify patients who are at high risk for developing this disease...
November 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27755823/clinical-impact-of-post-progression-survival-on-overall-survival-in-elderly-patients-with-extensive-disease-small-cell-lung-cancer
#12
Hisao Imai, Keita Mori, Nodoka Watase, Toshifumi Kazama, Sakae Fujimoto, Kyoichi Kaira, Masanobu Yamada, Koichi Minato
BACKGROUND: The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with small-cell lung cancer (SCLC). Therefore, the objective of our study was to determine the relationships between progression-free survival (PFS) or post-progression survival (PPS) and OS after first-line chemotherapy in elderly patients with extensive disease-SCLC (ED-SCLC), using individual level data. METHODS: Between July 1998 and December 2014, we analyzed 57 cases of elderly patients with ED-SCLC who were treated with carboplatin and etoposide as first-line chemotherapy...
August 1, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27746999/a-randomized-open-multicenter-clinical-study-on-the-short-course-of-intravenous-infusion-of-750-mg-of-levofloxacin-and-the-sequential-standard-course-of-intravenous-infusion-oral-administration-of-500-mg-of-levofloxacin-for-treatment-of-community-acquired-pneumonia
#13
Tiemei Zhao, Liang-An Chen, Ping Wang, Guizhen Tian, Feng Ye, Huili Zhu, Bei He, Baiying Zhang, Changzhou Shao, Zhijun Jie, Xiwen Gao, Dongxia Wang, Weidong Song, Zhijie Pan, Jin Chen, Xingyi Zhang, Zhancheng Gao, Ping Chen, Youning Liu
BACKGROUND: To compare 5-day regimen of levofloxacin 750 mg IV daily with 7-14-day conventional regimen of levofloxacin 500 mg intravenous to oral (IV/PO) daily for treatment of community-acquired pneumonia (CAP) in Chinese population. METHODS: This was a non-inferiority study to assess the difference of clinical efficacy at the end of treatment (EOT) between two regimens. Adult CAP patients with CURB-65 score 0-2 were enrolled from 17 hospitals in China from November 2012 to July 2014...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27701748/effect-of-high-hydrostatic-pressure-on-the-polyphenols-and-antioxidant-activity-of-plantain-pulp-musa-paradisiaca-aab
#14
Miriam C Jiménez-Martínez, Efigenia Montalvo-González, Sonia G Sáyago-Ayerdi, Gilberto Mercado-Mercado, José A Ramírez-de León, Ernestina Paz-Gamboa, Maria A Vivar-Vera
BACKGROUND: The impact of high-pressure processing (HPP) on the polyphenol (PP) content and antioxidant activity (AOX) of plantain pulp was evaluated. Pressures of 400, 500 and 600 MPa were applied to plantain pulp for 90 and 180 s at room temperature (25 °C). Polyphenoloxidase activity, extractable (EPP) and non-extractable PP (NEPP) contents, flavonoid content and AOX (FRAP, ABTS(•+) ) were evaluated. In addition, PP identification was performed using high-performance liquid chromatography...
October 4, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27623357/the-palliative-performance-scale-predicts-three-and-six-month-survival-in-older-adult-patients-admitted-to-the-hospital-through-the-emergency-department
#15
Matthew Babcock, Joanne Gould Kuntz, Dan Kowalsky, Nicholas Calitri, Anne M Kenny
BACKGROUND: There is often little information on long-term prognosis available for Emergency Medicine physicians when decisions on admission, treatment, or consultations are being made for patients. There is a new focus to understand if palliative support should be offered in the emergency department (ED) and the Palliative Performance Scale (PPS), a screening tool used in other settings in palliative care, has been little used in the ED. OBJECTIVE: The goal of this study was to assess the prognostic value of the PPS in predicting three- and six-month survival in patients admitted through the ED...
September 13, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27614759/intravesical-treatment-for-interstitial-cystitis-painful-bladder-syndrome-a-network-meta-analysis
#16
Wei Zhang, Xiaojing Deng, Chunyu Liu, Xu Wang
INTRODUCTION AND HYPOTHESIS: Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic inflammatory condition of the submucosal and muscular layers of the bladder. So far, there is no effective and targeted treatment strategy for IC/PBS. This study aimed to assess the efficacy and safety of intravesical instillation treatment in IC/PBS patients. METHODS: We searched various databases up to October 2015. A network meta-analysis was performed to compare global response assessment (GRA) for different treatment strategies, including botulinum toxin A (BoNTA), bacillus Calmette-Guerin (BCG), resiniferatoxin (RTX), lidocaine, chondroitin sulfate (CS), oxybutynin, and pentosan polysulfate (PPS)...
September 10, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27601272/berberine-induces-pacemaker-potential-inhibition-via-cgmp-dependent-atp-sensitive-k-channels-by-stimulating-mu-delta-opioid-receptors-in-cultured-interstitial-cells-of-cajal-from-mouse-small-intestine
#17
Hyun Jung Kim, Hyungwoo Kim, Myeong Ho Jung, Young Kyu Kwon, Byung Joo Kim
Berberine is traditionally used to treat gastrointestinal (GI) motility disorders. The interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal tract, which are responsible for the production of gut movements. The present study aimed to investigate the effects of berberine on pacemaker potentials (PPs) in cultured ICC clusters from the mouse small intestine, and sought to identify the receptors involved and the underlying mechanisms of action. All experiments were performed on cultured ICCs, and a whole‑cell patch‑clamp configuration was used to record PPs from ICC clusters (current clamp mode)...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27590932/integrating-gdm-management-in-public-health-pakistan-perspective
#18
Musarrat Riaz, Abdul Basit
Pakistan is a developing country with diverse social, economic and cultural dimensions along with limited resources. Non communicable diseases (NCDS) including diabetes are highly prevalent compromising the already challenged health care system. Gestational diabetes mellitus (GDM) with its associated maternal and foetal complications is increasing with rapidly changing lifestyle pattern. Since Pakistan has limited resources and other health issues compete strongly with gestational diabetes initiatives, the most feasible strategy will be the horizontal integration...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27590017/treatment-with-pentosan-polysulphate-in-patients-with-mps-i-results-from-an-open-label-randomized-monocentric-phase-ii-study
#19
Julia B Hennermann, Seyfullah Gökce, Alexander Solyom, Eugen Mengel, Edward H Schuchman, Calogera M Simonaro
Current treatment options for MPS I have limited effects on some organs, including the skeletal system. In MPS animal models pentosan polysulphate (PPS) reduces the concentrations of glycosaminoglycans (GAGs) in tissues and body fluids and improves cartilaginous and osseous pathologies. The goals of this study were to investigate primarily the safety and secondary the clinical effects, concerning mobility and pain, of PPS treatment in MPS I patients. Four MPS I-Hurler-Scheie/-Scheie patients aged 35.6 ± 6...
November 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27582139/integrating-gdm-management-in-public-health-pakistan-perspective
#20
Musarrat Riaz, Abdul Basit
Pakistan is a developing country with diverse social, economic and cultural dimensions along with limited resources. Non communicable diseases (NCDS) including diabetes are highly prevalent compromising the already challenged health care system. Gestational diabetes mellitus (GDM) with its associated maternal and foetal complications is increasing with rapidly changing lifestyle pattern. Since Pakistan has limited resources and other health issues compete strongly with gestational diabetes initiatives, the most feasible strategy will be the horizontal integration...
September 2016: JPMA. the Journal of the Pakistan Medical Association
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