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https://www.readbyqxmd.com/read/29429842/trabectedin-in-ovarian-cancer-is-it-now-a-standard-of-care
#1
J Ventriglia, I Paciolla, S C Cecere, C Pisano, M Di Napoli, L Arenare, S V Setola, N S Losito, D Califano, M Orditura, S Pignata
In patients with recurrent ovarian cancer, the choice of second-line therapy is complex. Several factors have to be considered, such as platinum-free interval (PFI), residual toxicity from the previous treatments, BRCA1/2 gene mutation status. Trebectedin is a minor groove DNA binder derived from a marine organism that has shown efficacy in different settings in ovarian cancer therapy. It has been approved in the treatment of partially platinum sensitive (PPS) (PFI between 6 and 12 months) relapsed ovarian cancer according to the statistically significant progression-free survival (7...
February 8, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29417279/tumors-of-the-parapharyngeal-space-the-vu-university-medical-center-experience-over-a-20-year-period
#2
Thijs van Hees, Stijn van Weert, Birgit Witte, C René Leemans
BACKGROUND: Tumors of the parapharyngeal space (PPS) are rare, accounting for 0.5-1.5% of all head and neck tumors. The anatomy of the PPS is responsible for a wide variety of tumors arising from the PPS. This series of 99 PPS tumors provides an overview of the clinical course and management of PPS tumors. MATERIALS AND METHODS: This retrospective study included clinical data from patients treated for PPS tumors from 1991 to 2012 (warranting at least a 4-year follow-up) at the VU University Medical Center, Amsterdam, The Netherlands...
February 7, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29395473/application-of-radiopaque-micro-particle-fillers-for-3-d-imaging-of-periodontal-pocket-analogues-using-cone-beam-ct
#3
M Elashiry, M M Meghil, S Kalathingal, A Buchanan, R Elrefai, S Looney, M Rajendran, M Ochieng, N Young, A Elawady, R M Arce, K H Sandhage, C W Cutler
BACKGROUND: Periodontitis is an infectious/inflammatory disease most often diagnosed by deepening of the gingival sulcus, which leads to periodontal pockets (PPs) conventional manual periodontal probing does not provide detailed information on the three-dimensional (3-D) nature of PPs. OBJECTIVES: To determine whether accurate 3-D analyses of the depths and volumes of calibrated PP analogues (PPAs) can be obtained by conventional cone beam computed tomography (CBCT) coupled with novel radiopaque micro-particle fillers (described in the companion paper) injected into the PPAs...
January 29, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29394580/-treatment-out-come-of-eribulin-in-patients-with-advanced-or-metastatic-breast-cancer-who-resistant-to-anthracycline-and-taxane
#4
Natsuko Tanaka, Kaoru Ogura, Akinori Hattori, Hiroaki Inoue, Hiroko Yukawa, Shiho Sakaguchi, Aya Matsuoka, Asaka Kodera, Yoshihiko Naritaka, Akira Hirano
PATIENTS AND METHODS: This retrospective observational study contains advanced or metastatic breast cancer female patients who pretreated with anthracycline and/or taxane received eribulin(ERI)mesylate. The primary endpoint was the progressionfree survival(PFS)and secondary endopoints were objective response rate(ORR), clinical benefit rate(CBR), overall survival (OS), and post-progression survival(PPS). RESULTS: A total of 32 patients underwent chemotherapy cycles(median 3; range 1-9 cycles)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29336057/modification-of-lymphocyte-migration-to-peyer-s-patches-by-inhibition-of-sphingosine-1-phosphate-lyase-ameliorates-murine-colitis
#5
Kazuhiko Shirakabe, Masaaki Higashiyama, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Masayuki Saruta, Ryota Hokari
BACKGROUND AND AIM: Sphingosine-1-phosphate (S1P) receptor 1, a therapeutic target of the S1P1 agonist FTY720, plays a crucial role in lymphocyte migration and is expressed in several cells including naïve T lymphocytes and endothelial cells. 2-acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase (SPL), exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear. We aimed to clarify how THI affects colitis and migration of naïve T lymphocytes in Peyer's patches (PPs)...
January 15, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29335909/persistent-posterior-seroma-after-laparoscopic-repair-of-ventral-abdominal-wall-hernias-with-expanded-polytetrafluoroethylene-mesh-prevalence-independent-predictors-and-detached-tacks-retrospective-review
#6
V M A Stirler, R J de Haas, J T F J Raymakers, S Rakic
PURPOSE: A persistent seroma located posterior to a mesh (PPS) remains a little known complication after laparoscopic ventral hernia repair (LVHR). The aim of this large case series was to analyse the prevalence and clinical course as well as identify related factors and independent predictors of PPS. METHODS: All 1288 adult patients who underwent a LVHR with an expanded polytetrafluoroethylene mesh (ePTFE) between January 2003 and July 2014 were reviewed. Those who underwent an abdominal computed tomography (CT) scan more than 3 months afterwards (n = 166) were included and their scans were analysed...
January 15, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29305302/actual-state-of-knowledge-in-the-field-of-diseases-related-with-defective-nucleotide-excision-repair
#7
REVIEW
Barbara Bukowska, Bolesław T Karwowski
Xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome (CS) are rare genetic diseases characterized by a large range of clinical symptoms. However, they are all associated with defects in nucleotide excision repair (NER), the system responsible for removing bulky DNA lesions such as those generated by UV light: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone photoproducts (6-4 PPs). Over the past years, detailed structural and biochemical information on NER-associated proteins has emerged...
January 2, 2018: Life Sciences
https://www.readbyqxmd.com/read/29285368/role-of-endometriosis-as-a-prognostic-factor-for-post-progression-survival-in-ovarian-clear-cell-carcinoma
#8
Hiroki Ishibashi, Masashi Takano, Morikazu Miyamoto, Hiroaki Soyama, Hiroko Matsuura, Tadashi Aoyama, Tomoyuki Yoshikawa, Kento Kato, Hitoshi Tsuda, Kenichi Furuya
The clinical significance of coexistence of endometriosis (EM) in ovarian clear cell carcinoma (CCC) has not yet been determined. The aim of the present study was to analyze the correlation of endometriosis with clinicopathological factors in CCC. The cases with CCC that received primary debulking surgery at the present hospital between 1990 and 2013 were identified. Retrospective analysis was conducted to evaluate the association between complications with EM and clinicopathological features in CCC. Of the 105 cases enrolled in the study, 45 cases were complicated with EM, and 60 cases did not have EM (non-EM)...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29279133/repetitive-transcranial-magnetic-stimulation-in-treatment-of-post-polio-syndrome
#9
Żanna Pastuszak, Renata Piusińska-Macoch, Adam Stępień, Zbigniew Czernicki
BACKGROUND: Post polio syndrome is a rare disease that occurs decades after polio virus infection. Repetitive transcranial magnetic stimulation (rTMS) is a treatment option with proved effectiveness in drug resistant depression. Possibly it can be helpful in therapy of other neurological diseases including post polio syndrome. OBJECTIVE: To describe a case of patient diagnosed with post polio syndrome who was treated with rTMS stimulation with a good effect. METHODS: Patient had rTMS stimulation of left prefrontal cortex twice a week for an eight weeks...
November 5, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29262509/-efficacy-of-weitan-waifu-patch-on-the-postsurgical-gastroparesis-syndrome-of-gastrointestinal-cancer-a-multi-center-trial
#10
Q Zhou, M H Zuo, Q W Li, Y T Tian, Y B Xie, Y B Wang, G Y Yang, Y J Ye, P Guo, J P Liu, Z L Liu, C An, T Zhou, Z Tian, C B Liu, Y Hu, X Y Chi, Y Shen, Y Xia, K W Hu
Objective: To investigate the safety and efficacy of the Weitan Waifu patch on the postsurgical gastroparesis syndrome (PGS) of gastrointestinal cancer. Methods: The multi-center, double-blind, randomized controlled trial was conducted with superiority design. Patients with PGS of gastrointestinal cancer diagnosed in 4 AAA hospitals and the abdominal symptom manifested as cold syndrome by Chinese local syndrome differentiation were recruited. These patients were randomly divided into two groups according to 1∶1 proportion...
December 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29258915/cinnamon-a-promising-prospect-towards-alzheimer-s-disease
#11
REVIEW
Saeideh Momtaz, Shokoufeh Hassani, Fazlullah Khan, Mojtaba Ziaee, Mohammad Abdollahi
Over the last decades, an exponential increase of efforts concerning the treatment of Alzheimer's disease (AD) has been practiced. Phytochemicals preparations have a millenary background to combat various pathological conditions. Various cinnamon species and their biologically active ingredients have renewed the interest towards the treatment of patients with mild-to-moderate AD through the inhibition of tau protein aggregation and prevention of the formation and accumulation of amyloid-β peptides into the neurotoxic oligomeric inclusions, both of which are considered to be the AD trademarks...
December 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29248998/measuring-what-matters-most-validation-of-the-measure-of-ovarian-symptoms-and-treatment-a-patient-reported-outcome-measure-of-symptom-burden-and-impact-of-chemotherapy-in-recurrent-ovarian-cancer
#12
Madeleine T King, Martin R Stockler, Rachel L O'Connell, Luke Buizen, Florence Joly, Anne Lanceley, Felix Hilpert, Aikou Okamoto, Eriko Aotani, Jane Bryce, Paul Donnellan, Amit Oza, Elisabeth Avall-Lundqvist, Jonathan S Berek, Jalid Sehouli, Amanda Feeney, Dominique Berton-Rigaud, Daniel S J Costa, Michael L Friedlander
PURPOSE: Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. METHODS: GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with ≥ 3 lines of prior chemotherapy (PPS-ROC ≥ 3)...
December 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29218467/antibiotic-prescription-and-clinical-management-of-common-infections-among-general-practitioners-in-latvia-lithuania-and-sweden-a-pilot-survey-with-a-simple-protocol
#13
Uga Dumpis, Annika Hahlin, Sonata Varvuolyte, Stephan Stenmark, Sarmīte Veide, Rolanda Valinteliene, Asta Jurkeviciene, Johan Struwe
Comparative information on diagnosis-related antibiotic prescribing patterns are scarce from primary care within and between countries. To describe and compare antibiotic prescription and routine management of infections in primary care in Latvia (LV), Lithuania (LT) and two study sites in Sweden (SE), a cross-sectional observational study on patients who consulted due to sypmtoms compatible with infection was undetraken. Infection and treatment was detected and recorded by physicians only. Data was collected from altogether 8786 consecutive patients with infections in the three countries...
December 7, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29207166/pentosan-polysulfate-ameliorates-apoptosis-and-inflammation-by-suppressing-activation-of-the-p38-mapk-pathway-in-high-glucose%C3%A2-treated-hk%C3%A2-2-cells
#14
Ping Chen, Yang Yuan, Tianying Zhang, Bo Xu, Qing Gao, Tianjun Guan
The apoptosis of tubular epithelial cells in diabetic nephropathy (DN) is commonly observed in human renal biopsies. Inflammation plays a key role in DN, and pentosan polysulfate (PPS) has been shown to largely attenuate the inflammation of nephropathy in aging diabetic mice. p38 mitogen‑activated protein kinase (p38 MAPK) plays a crucial role in tissue inflammation and cell apoptosis, and it is activated by hyperglycemia. In the present study, high glucose (HG)‑treated human renal proximal tubular epithelial cells (HK‑2) were used to examine the protective effects of PPS against HG‑stimulated apoptosis and inflammation...
November 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205989/postpericardiotomy-syndrome
#15
Joonas Lehto, Juha Virolainen
Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery. In most cases it develops 2 to 3 weeks after the operation. An inflammatory reaction develops in the pericardium or pleural space with fever, chest pain and dyspnea as typical symptoms. The disease process is usually self-limiting. At present, the etiology is unknown, but an immunological mechanism is suspected as the cause of the disease. The incidence of PPS is essentially dependent on diagnostic criteria, patient group and type of operation...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29203844/complications-functional-and-quality-of-life-outcomes-following-primary-and-secondary-implantation-of-penile-prosthesis-at-a-tertiary-referral-center
#16
Bernhard Ralla, Irena Goranova, Niels Börnstein, Frank Friedersdorff, Andreas Maxeiner, Ahmed Magheli, Stefan Hinz, Joerg Neymeyer, Kurt Miller, Jonas Busch
The implantation of a penile prosthesis (PP) may be recommended in patients with severe erectile dysfunction (ED) who do not respond to conservative treatments. The aim of this study was to evaluate complications, as well as functional and quality of life outcomes following primary and secondary implantation of PP at a tertiary referral center. In this retrospective study, a total of 51 patients (41 patients with primary (PPP) and 10 with secondary PP (SPP)) were included. Patients and operative characteristics were recorded and complications were analyzed using the Clavien-Dindo classification...
December 4, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29194961/computational-simulation-of-postoperative-pulmonary-flow-distribution-in-alagille-patients-with-peripheral-pulmonary-artery-stenosis
#17
Weiguang Yang, Frank L Hanley, Frandics P Chan, Alison L Marsden, Irene E Vignon-Clementel, Jeffrey A Feinstein
BACKGROUND: Up to 90% of individuals with Alagille syndrome have congenital heart diseases. Peripheral pulmonary artery stenosis (PPS), resulting in right ventricular hypertension and pulmonary flow disparity, is one of the most common abnormalities, yet the hemodynamic effects are ill-defined, and optimal patient management and treatment strategies are not well established. The purpose of this pilot study is to use recently refined computational simulation in the setting of multiple surgical strategies, to examine the influence of pulmonary artery reconstruction on hemodynamics in this population...
December 1, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/29160008/clinical-diagnosis-and-treatment-outcomes-for-parapharyngeal-space-schwannomas-a-single-institution-review-of-21-cases
#18
Yoichiro Sato, Yorihisa Imanishi, Toshiki Tomita, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoshihiro Watanabe, Mariko Sekimizu, Kaoru Ogawa
BACKGROUND: Because the incidence of schwannoma arising from the parapharyngeal space (PPS) is very low, no studies have analyzed extirpation methods and postoperative neurological complications exclusively in PPS schwannomas. METHODS: The preoperative diagnosis and clinical outcomes of surgical treatment in 21 patients with PPS schwannoma who underwent surgery were investigated. RESULTS: Neurological deficit of the involved nerve developed in all patients regardless of the extirpation method used...
November 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/29105206/risk-factors-for-psychological-and-psychosomatic-symptoms-among-children-with-malignancies
#19
Kenichi Maeda, Daisuke Hasegawa, Kevin Y Urayama, Shinichi Tsujimoto, Yuriko Azami, Miwa Ozawa, Atsushi Manabe
AIM: With increasing survival rates in paediatric malignancies, the quality-of-life of children during hospitalisation should be given more attention. We aimed to identify factors associated with psychological and psychosomatic symptoms (PPS) that required medication among children hospitalised for treatment of malignancies. METHODS: We retrospectively analysed data of 190 patients aged 2-18 years old. They were diagnosed with malignant diseases and admitted for treatment at St...
November 3, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29099000/enhancing-the-role-of-private-practitioners-in-tuberculosis-prevention-and-care-activities-in-india
#20
REVIEW
Tanu Anand, Ranjith Babu, Anil G Jacob, Karuna Sagili, Sarabjit S Chadha
India accounts for the highest number of incident tuberculosis (TB) cases globally. Hence, to impact the TB incidence world over, there is an urgent need to address and accelerate TB control activities in the country. Nearly, half of the TB patients first seek TB care in private sector. However, the participation of private practitioners (PPs) has been patchy in TB prevention and care and distrust exists between public and private sector. PPs usually have varied diagnostic and treatment practices that are inadequate and amplify the risk of drug resistance...
November 2017: Lung India: Official Organ of Indian Chest Society
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