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https://www.readbyqxmd.com/read/29037186/comparison-of-serum-markers-for-muscle-damage-surgical-blood-loss-postoperative-recovery-and-surgical-site-pain-after-extreme-lateral-interbody-fusion-with-percutaneous-pedicle-screws-or-traditional-open-posterior-lumbar-interbody-fusion
#1
Tetsuro Ohba, Shigeto Ebata, Hirotaka Haro
BACKGROUND: The benefits of extreme lateral interbody fusion (XLIF) as a minimally invasive lumbar spinal fusion treatment for lumbar degenerative spondylolisthesis have been unclear. We sought to evaluate the invasiveness and tolerability of XLIF with percutaneous pedicle screws (PPS) compared with traditional open posterior lumbar interbody fusion (PLIF). METHODS: Fifty-six consecutive patients underwent open PLIF and 46 consecutive patients underwent single-staged treatment with XLIF with posterior PPS fixation for degenerative lumbar spondylolisthesis, and were followed up for a minimum of 1 year...
October 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29033569/associations-among-depression-severity-painful-physical-symptoms-and-social-and-occupational-functioning-impairment-in-patients-with-major-depressive-disorder-a-3-month-prospective-observational-study
#2
Eiji Harada, Yoichi Satoi, Atsushi Kuga, Hirofumi Tokuoka, Toshiaki Kikuchi, Koichiro Watanabe, Levent Alev, Masaru Mimura
PURPOSE: To investigate associations among depression severity, painful physical symptoms (PPS), and social and occupational functioning impairment in patients with major depressive disorder (MDD) who had achieved complete remission (CR) or partial remission (PR) after acute treatment. PATIENTS AND METHODS: This was a 12-week, multicenter, prospective, observational study. Patients with MDD treated with an antidepressant medication for the previous 12 weeks (±3 weeks) who had achieved CR (defined as a 17-item Hamilton Rating Scale for Depression [HAM-D17] score ≤7) or PR (HAM-D17 score ≥8 and ≤18) were enrolled...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29026309/predicting-treatment-outcomes-of-major-depressive-disorder-by-early-improvement-in-painful-physical-symptoms-a-pooled-analysis-of-double-blind-placebo-controlled-trials-of-duloxetine
#3
Hirofumi Tokuoka, Makoto Nishihara, Shinji Fujikoshi, Aki Yoshikawa, Atsushi Kuga
OBJECTIVE: We determined if early improvement in painful physical symptoms (PPS) can be a predictor of remission in the treatment of major depressive disorder (MDD). METHODS: We included randomized, double-blind, parallel-group clinical trials of duloxetine (40-60 mg/day) versus placebo for the acute treatment of MDD with associated PPS. Only those studies using the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Brief Pain Inventory - Short Form (BPI-SF) were included...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28989540/immunotheranostic-polymersomes-modularly-assembled-from-tetrablock-and-diblock-copolymers-with-oxidation-responsive-fluorescence
#4
Fanfan Du, Yu-Gang Liu, Evan Alexander Scott
INTRODUCTION: Intracellular delivery is a key step for many applications in medicine and for investigations into cellular function. This is particularly true for immunotherapy, which often requires controlled delivery of antigen and adjuvants to the cytoplasm of immune cells. Due to the complex responses generated by the stimulation of diverse immune cell populations, it is critical to monitor which cells are targeted during treatment. To address this issue, we have engineered an immunotheranostic polymersome delivery system that fluorescently marks immune cells following intracellular delivery...
October 2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/28979720/polyethylene-glycol-microspheres-loaded-with-irinotecan-for-arterially-directed-embolic-therapy-of-metastatic-liver-cancer
#5
Giammaria Fiorentini, Riccardo Carandina, Donatella Sarti, Michele Nardella, Odysseas Zoras, Stefano Guadagni, Riccardo Inchingolo, Massimiliano Nestola, Alessandro Felicioli, Daniel Barnes Navarro, Fernando Munoz Gomez, Camillo Aliberti
AIM: To study tumor response, and tolerability of arterially directed embolic therapy (ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases (CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients. METHODS: Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%...
September 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28969433/accuracy-of-pre-interventional-computed-tomography-angiography-post-processing-software-and-extravascularly-calibrated-devices-to-determine-vessel-diameters-comparison-with-an-intravascularly-located-calibrated-catheter
#6
Erik Stahlberg, Mathis Planert, Susanne Anton, Nikolaos Panagiotopoulos, Marco Horn, Joerg Barkhausen, Jan Peter Goltz
Background Accurate vessel sizing might affect treatment outcome of endovascular therapy. Purpose To compare accuracy of peripheral vessel diameter measurements using pre-interventional computed tomography angiography post processing software (CTA-PPS) and extravascularly located calibrated devices used during digital subtraction angiography (DSA) with an intravascular scaled catheter (SC). Material and Methods In 33 patients (28 men, mean age = 72 ± 11 years) a SC was used during DSA of the femoro-popliteal territory...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28950421/phase-3-randomized-study-of-sb5-an-adalimumab-biosimilar-versus-reference-adalimumab-in-patients-with-moderate-to-severe-rheumatoid-arthritis
#7
Michael E Weinblatt, Asta Baranauskaite, Jaroslaw Niebrzydowski, Eva Dokoupilova, Agnieszka Zielinska, Janusz Jaworski, Artur Racewicz, Margarita Pileckyte, Krystyna Jedrychowicz-Rosiak, Soo Yeon Cheong, Jeehoon Ghil
OBJECTIVES: SB5 is a proposed adalimumab biosimilar. This study compared the efficacy, pharmacokinetics (PK), safety, and immunogenicity of SB5 versus reference adalimumab (ADL) in patients with rheumatoid arthritis (RA). METHODS: In this phase 3, randomized, double-blind, parallel-group study, patients with moderate to severe RA despite methotrexate treatment were randomized 1:1 to receive SB5 or ADL 40 mg subcutaneously every other week. The primary efficacy endpoint was the American College of Rheumatology 20% (ACR20) response at week 24 in the per-protocol set (PPS; completer analysis)...
September 26, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28927073/surgical-treatment-of-parapharyngeal-space-tumors-a-report-of-29-cases
#8
Kei Ijichi, Shingo Murakami
The present study aimed to establish a strategy for parapharyngeal space (PPS) tumor surgery based on preoperative symptoms, clinical signs, imaging and histological examination. A retrospective cohort study was conducted with 29 adult patients who underwent surgery for primary PPS tumors from 2008-2015. The following data was obtained: Preoperative symptoms of the patient, histological type of the tumor, surgical approach and complications. Of the 29 patients who underwent surgery to remove a PPS tumor, 16 presented with neurogenic tumors and 13 with salivary gland tumors...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28899386/improved-clinical-outcome-measures-of-knee-pain-and-function-with-concurrent-resolution-of-subchondral-bone-marrow-edema-lesion-and-joint-effusion-in-an-osteoarthritic-patient-following-pentosan-polysulphate-sodium-treatment-a-case-report
#9
Matthew J Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou, Jeganath Krishnan
BACKGROUND: At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are left with limited treatment options, and may resort to operative management with Total Knee Arthroplasty (TKA). We report the use of Pentosan Polysulphate Sodium (PPS) for the treatment of BMLs of the knee. CASE PRESENTATION: We report the case of a 70-year-old female with knee osteoarthritis presenting with a high level of knee pain, scoring 8 on the Numerical Rating Scale (NRS), and functional limitation demonstrating a poor Lysholm Knee Score of 37...
September 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28846483/palliative-care-needs-in-an-acute-internal-medicine-ward-in-mexico
#10
Tania Zertuche-Maldonado, Rodrigo Tellez-Villarreal, Antonio Pascual, Salvador B Valdovinos-Chavez, Abel Jesus Barragan-Berlanga, Maria Teresa Sanchez-Avila, Leonardo Bracho-Vela, Adria Tinoco-Aranda, Eduardo Bruera
BACKGROUND: Palliative care is an evolving but underdeveloped practice in Mexico. OBJECTIVE: The primary end point of this prospective observational study was to identify internal medicine inpatients fulfilling advanced criteria within a second-level hospital. Secondary end points were symptom burden, treatment, resource utilization, and one-year survival. DESIGN AND MEASUREMENTS: The 390-sample size calculation was based on previous studies where 15% of inpatients fulfilled palliative care needs...
August 28, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28840372/persistent-perineal-sinus-after-abdominoperineal-resection
#11
Amélie Chau, Mathieu Prodeau, Hélène Sarter, Corinne Gower, Moshe Rogosnitzky, Yves Panis, Philippe Zerbib
BACKGROUND AND AIMS: Persistent perineal sinus (PPS) defined as a perineal wound remaining unhealed more than 6 months after abdominoperineal resection (APR) is a well-known complication. The aim of our study was (1) to evaluate the incidence of PPS after APR for Crohn's disease (CD) in the era of biotherapy, (2) to determine long-term outcome of PPS, (3) to study risk factors associated with delayed perineal healing, and (4) to compare the results in this CD patient group with patients without CD...
August 25, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28835709/glycoprotein-2-is-a-specific-cell-surface-marker-of-human-pancreatic-progenitors
#12
Kathryn F Cogger, Ankit Sinha, Farida Sarangi, Emily C McGaugh, Diane Saunders, Craig Dorrell, Salvador Mejia-Guerrero, Yasaman Aghazadeh, Jillian L Rourke, Robert A Screaton, Markus Grompe, Philip R Streeter, Alvin C Powers, Marcela Brissova, Thomas Kislinger, M Cristina Nostro
PDX1(+)/NKX6-1(+) pancreatic progenitors (PPs) give rise to endocrine cells both in vitro and in vivo. This cell population can be successfully differentiated from human pluripotent stem cells (hPSCs) and hold the potential to generate an unlimited supply of β cells for diabetes treatment. However, the efficiency of PP generation in vitro is highly variable, negatively impacting reproducibility and validation of in vitro and in vivo studies, and consequently, translation to the clinic. Here, we report the use of a proteomics approach to phenotypically characterize hPSC-derived PPs and distinguish these cells from non-PP populations during differentiation...
August 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28831260/an-observational-study-of-duloxetine-versus-ssri-monotherapy-in-japanese-patients-with-major-depressive-disorder-subgroup-analyses-of-treatment-effectiveness-for-pain-depressive-symptoms-and-quality-of-life
#13
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: To examine how clinical and demographic patient baseline characteristics influence effectiveness of duloxetine versus selective serotonin reuptake inhibitor (SSRI) treatment, in real-world Japanese clinical settings of patients with major depressive disorder (MDD) and associated painful physical symptoms (PPS). METHODS: This was a multicenter, 12-week, prospective, observational study in patients with MDD (Quick Inventory of Depressive Symptomatology ≥16) and at least moderate PPS (Brief Pain Inventory-Short Form [BPI-SF] average pain ≥3)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28831259/an-observational-study-of-duloxetine-versus-ssri-monotherapy-for-the-treatment-of-painful-physical-symptoms-in-japanese-patients-with-major-depressive-disorder-primary-analysis
#14
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Mako Matsubara, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: The objective of this study was to assess the effectiveness of duloxetine monotherapy, in comparison with selective serotonin reuptake inhibitor (SSRI) monotherapy, in the treatment of painful physical symptoms (PPS) in Japanese patients with major depressive disorder (MDD) in real-world clinical settings. METHODS: This was a multicenter, 12-week prospective, observational study. This study enrolled MDD patients with at least moderate PPS, defined as a Brief Pain Inventory-Short Form (BPI-SF) average pain score (item 5) ≥3...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28831250/an-evaluation-of-activity-tolerance-patient-reported-outcomes-and-satisfaction-with-the-effectiveness-of-pulmonary-daoyin-on-patients-with-chronic-obstructive-pulmonary-disease
#15
Hai-Long Zhang, Jian-Sheng Li, Xue-Qing Yu, Su-Yun Li, Upur Halmurat, Yang Xie, Yan-Fang Wang, Feng-Sen Li, Ming-Hang Wang
BACKGROUND AND OBJECTIVE: Pulmonary Daoyin (PD) (evolved from ancient Chinese daoyin skills), is a rehabilitation technology that combines specially designed movements of the arms and body and controlled breathing exercises, to improve the physiological and psychological status of patients with chronic respiratory disease. Pulmonary rehabilitation is effective for patients with chronic obstructive pulmonary disease (COPD), and the efficacy of PD is unknown. The aim of this study is to investigate the effect of a PD program in enhancing activity tolerance, patient-reported outcomes and satisfaction with the effectiveness on patients with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28807020/feasibility-study-of-strengthening-the-public-private-partnership-for-tuberculosis-case-detection-in-bandung-city-indonesia
#16
Bony Wiem Lestari, Nita Arisanti, Adiatma Y M Siregar, Estro Dariatno Sihaloho, Gelar Budiman, Philip C Hill, Bachti Alisjahbana, Susan McAllister
OBJECTIVE: Private practitioner's (PPs) collaboration for detection, diagnosis and treatment of tuberculosis (TB) is recommended by the World Health Organization and encouraged by the Indonesian National TB control programme. TB case management by PPs, however, are mostly not in line with current guidelines. Therefore, we developed an intervention package for PPs comprising of TB training, implementation of a mobile phone application for notification of TB cases and a 6-month regular follow-up with PPs...
August 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28806111/-effectiveness-of-mindfulness-based-cancer-recovery-mbcr-program-among-hungarian-cancer-patients
#17
Magda Rohánszky, Károly Berényi, Dóra Fridrik, Henriette Pusztafalvi
INTRODUCTION AND AIM: Employment of mindfulness-based programs and techniques in the treatment of cancer patients have spread exponentially in the past decade. A large number of studies have proved the effectiveness of the program in the reduction of stress symptoms, depression and anxiety, and the improvement of sleep and mood patterns. The present study was done at Firebird Foundation and examines the effectiveness of the complex, MBCR (mindfulness-based cancer recovery)-based psycho-social intervention in the treatment of cancer patients...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28777825/beyond-disease-progression-clinical-outcomes-after-egfr-tkis-in-a-cohort-of-egfr-mutated-nsclc-patients
#18
Roxana Alina Tudor, Adrijana D'Silva, Alain Tremblay, Paul MacEachern, Don Morris, Darren Brenner, Karen Kopciuk, Dafydd Gwyn Bebb
PURPOSE: Treatment and clinical-outcomes were described in a sub-cohort of non-small-cell lung cancer (NSCLC) patients with disease-progression (PD) after epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) treatment. PATIENTS AND METHODS: We retrospectively analyzed a single-institutional EGFR mutation positive (EGFRmut+) NSCLC cohort for post-TKI-PD management, and assessed overall survival (OS) and post-progression survival (PPS). All de-novo (first lung-cancer occurrence) stage IIIA-IV patients, as well as de-novo stage IV subset was analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28736952/validation-of-the-albi-grade-based-integrated-model-as-a-predictor-for-sorafenib-failed-hepatocellular-carcinoma
#19
Pei-Chang Lee, Yi-Tzen Chen, Yee Chao, Teh-Ia Huo, Chung-Pin Li, Chien-Wei Su, Mei-Hsuan Lee, Ming-Chih Hou, Fa-Yauh Lee, Han-Chieh Lin, Yi-Hsiang Huang
BACKGROUND AND AIMS: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC) but is challenging after treatment failure. Appropriate criteria for enrolling patients into second-line trials are still limited. In this study, we aimed to establish more objective criteria based on Albumin-Bilirubin (ALBI) grade to select patients with better post-progression survival (PPS) for second-line treatment. METHODS: Consecutive 404 advanced HCC patients receiving sorafenib were retrospectively enrolled...
July 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28728799/-mental-health-determines-the-quality-of-life-in-patients-with-cancer-related-neuropathic-pain-in-quito-ecuador
#20
Fernando Gordillo Altamirano, María José Fierro Torres, Nelson Cevallos Salas, María Cristina Cervantes Vélez
OBJECTIVE: To identify the main factors determining the health related quality of life (HRQL) in patients with cancer-related neuropathic pain in a tertiary care hospital. METHODS: A cross-sectional analytical study was performed on a sample of 237 patients meeting criteria for cancer-related neuropathic pain. Clinical and demographic variables were recorded including, cancer type, stage, time since diagnosis, pain intensity, physical functionality with the Palliative Performance Scale (PPS), and anxiety and depression with the Hospital Anxiety and Depression Scale (HADS)...
July 2017: Revista Colombiana de Psiquiatría
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