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ventricular ectopic

Sandeep Tak, Manoj Lakhotia, Alok Gupta, Amit Sagar, Gopal Bohra, Rajesh Bajari
A 55-year-old male presented with history of nausea, vomiting, palpitation paresthesis and profuse sweating in emergency department 2h after ingestion of "Bachnaag" (Aconite) root. Examination revealed shock with irregular pulses. Initial ECG showed frequent multifocal ventricular ectopics (VE), which later turned to short runs of ventricular tachycardia (VT). Immediate gastric lavage was done and activated charcoal given. Patient was treated with fluid resuscitation without any improvement in blood pressure...
September 2016: Indian Heart Journal
Marisol Martínez-Alanis, Silvia Ruiz-Velasco, Claudia Lerma
BACKGROUND: Most approaches to predict ventricular tachyarrhythmias which are based on RR intervals consider only sinus beats, excluding premature ventricular complexes (PVCs). The method known as heartprint, which analyses PVCs and their characteristics, has prognostic value for fatal arrhythmias on long recordings of RR intervals (>70,000 beats). OBJECTIVE: To evaluate characteristics of PVCs from short term recordings (around 1000 beats) and their prognostic value for imminent sustained tachyarrhythmia...
October 3, 2016: International Journal of Cardiology
Konstantin V Zavadovsky, Victor V Saushkin, Mikhail S Khlynin, Sergey V Popov, Yuri B Lishmanov
BACKGROUND: The aim of the study was to evaluate the impact of idiopathic ventricular tachycardia and premature ventricular beats on cardiac function and dyssynchrony and to elucidate relationships between data of scintigraphic and intracardiac electrophysiology studies. METHODS: The study comprised 64 patients with idiopathic ventricular arrhythmias (VA) (median age of 14 years ranging from 8 to 18 years). Control group comprised 20 patients (median age of 12 ranging from 7 to 16 years) without cardiac arrhythmias...
September 23, 2016: Pacing and Clinical Electrophysiology: PACE
Sandeep A Saha, Kousik Krishnan, Christopher Madias, Richard G Trohman
A 34-year-old man with Brugada syndrome (BrS) presented with electrical storm, manifested as multiple appropriate shocks from his implantable cardioverter-defibrillator over a period of 7 hours. He had not tolerated prior treatment with quinidine, and had self-discontinued cilostazol citing persistent palpitations. After stabilization with intravenous isoproterenol, an electrophysiology study was performed but no spontaneous or induced ventricular ectopic beats were identified. A three-dimensional (3D) endocardial electro-anatomic map of the right ventricular outflow tract (RVOT), pulmonic valve, and pulmonary artery, as well as a 3D epicardial map of the RVOT, were created...
September 19, 2016: Cardiology and Therapy
Min Qiu, Yong-He Dong, Feng Han, Jian-Min Qin, Hao-Nan Zhang, Jian-Xi Du, Xin-Min Hao, Yu-Mei Yang
It is well known that various traditional Chinese medicines produce antiarrhythmic actions. The aims of this study were to examine whether total flavones derived from Choerospondias axillaris folium (TFCF) also produced antiarrhythmic effects using a rat model of aconitine-induced arrhythmia and to compare these observations with the effects of total flavones of Choerospondias axillaris fructus (TFC). Wistar rats were orally administered TFC (0.2 g/kg) or TFCF (0.1, 0.2, or 0.4 g/kg) daily for 7 d. Subsequently, aconitine iv at 25 µg/kg was used to induce arrhythmia in these animals...
2016: Journal of Toxicology and Environmental Health. Part A
C Urso, B Canino, S Brucculeri, A Firenze, G Caimi
About 50% of deaths from heart failure (HF) are sudden, presumably referable to arrhythmias. Electrolyte and acid-base abnormalities are a frequent and potentially dangerous complication in HF patients. Their incidence is almost always correlated with the severity of cardiac dysfunction; furthermore leading to arrhythmias, these imbalances are associated with a poor prognosis. The frequency of ventricular ectopic beats and sudden cardiac death correlate with both plasma and whole body levels of potassium, especially in alkalemia...
July 2016: La Clinica Terapeutica
Kota Nakamura, Mako Beppu, Kaori Sakai, Hayata Yagyu, Saori Matsumaru, Takao Kohno, Mitsuharu Hattori
In the normal cerebellum, Purkinje cells (PCs) are generated in a zone along the ventricular surface, migrate radially, and align to form a single-cell layer. However, in mice lacking the secreted protein Reelin or its downstream adaptor protein Dab1, the majority of PCs are located ectopically in the deep cerebellar mass. Nonetheless, how Reelin regulates migration and alignment of PCs remains incompletely understood. Reelin has a highly-conserved C-terminal region (CTR), which is required for its full activity...
November 12, 2016: Neuroscience
Rajeev K Pathak, Brian P Betensky, Pasquale Santangeli, Sanjay Dixit
Most premature ventricular contractions (PVCs) arise from the right or left ventricular outflow tract. Some VPCs originate near the His-bundle region. However, there remains a paucity of information on PVCs originating directly from the cardiac conduction system. We describe two cases with idiopathic frequent PVCs that were mapped directly to the left bundle branch itself. We also provide an anatomic-based mapping and ablation approach for management of these uncommon and challenging arrhythmias. In both cases we were able to either eliminate or significantly suppress the ectopic source by applying radiofrequency at this location without causing any significant impairment of the atrioventricular conduction...
August 28, 2016: Journal of Cardiovascular Electrophysiology
Vessela Krasteva, Irena Jekova, Remo Leber, Ramun Schmid, Roger Abächerli
False intensive care unit (ICU) alarms induce stress in both patients and clinical staff and decrease the quality of care, thus significantly increasing both the hospital recovery time and rehospitalization rates. In the PhysioNet/CinC Challenge 2015 for reducing false arrhythmia alarms in ICU bedside monitor data, this paper validates the application of a real-time arrhythmia detection library (ADLib, Schiller AG) for the robust detection of five types of life-threatening arrhythmia alarms. The strength of the application is to give immediate feedback on the arrhythmia event within a scan interval of 3 s-7...
August 2016: Physiological Measurement
Cici Chenliu, Xiaoye Sheng, Pauline Dan, Yang Qu, Victoria Claydon, Eric Lin, Leif Hove-Madsen, Shubhayan Sanatani, Glen F Tibbits
BACKGROUND: Post-operative arrhythmias such as Junctional Ectopic Tachycardia (JET) and atrioventricular block (AVB) are serious post-operative complications for children with congenital heart disease. We hypothesize that ischemia reperfusion (I/R) related changes exacerbate these post-operative arrhythmias in the neonate heart and the administration of post-operative inotropes is contributory. OBJECTIVE: To study the effects of I/R and post-ischemic dopamine (DA) application on the automaticity and rhythmicity in immature and mature pacemaker cells and whole heart preparations...
July 20, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Peter Oosterhoff, Veronique M F Meijborg, Peter M van Dam, Pascal F H M van Dessel, Charly N W Belterman, Geert J Streekstra, Jacques M T de Bakker, Ruben Coronel, Thom F Oostendorp
BACKGROUND: Noninvasive imaging of cardiac activation before ablation of the arrhythmogenic substrate can reduce electrophysiological procedure duration and help choosing between an endocardial or epicardial approach. A noninvasive imaging technique was evaluated that estimates both endocardial and epicardial activation from body surface potential maps. We performed a study in isolated and in situ pig hearts, estimating activation from body surface potential maps during sinus rhythm and localizing endocardial and epicardial stimulation sites...
August 2016: Circulation. Arrhythmia and Electrophysiology
Po-Ching Chi, Shun-Chuan Chang, Chun-Ho Yun, Jen-Yuan Kuo, Chung-Lieh Hung, Charles Jia-Yin Hou, Chia-Yuan Liu, Fei-Shih Yang, Tung-Hsin Wu, Hiram G Bezerra, Hung-I Yeh
BACKGROUND: The associations between pericardial adiposity and altered atrial conduction had been demonstrated. However, data comparing differential effects of various body sites visceral adiposity on atrial and ventricular electrocardiographic alterations remains largely unknown. METHODS AND RESULTS: We assessed both peri-cardial fat (PCF) and peri-aortic visceral adiposity (TAT) using dedicated computed tomography (CT) software (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA), with anthropometrics including body mass index (BMI) and biochemical data obtained...
2016: PloS One
Kazuhiro Maeta, Hironori Edamatsu, Kaori Nishihara, Junji Ikutomo, Shymaa E Bilasy, Tohru Kataoka
Cerebral neocortex development in mammals requires highly orchestrated events involving proliferation, differentiation, and migration of neural progenitors and neurons. Rapgef2 and Rapgef6 constitute a unique family of guanine nucleotide exchange factors for Rap1 small GTPase, which is known to play crucial roles in migration of postmitotic neurons. We previously reported that conditional knockout of Rapgef2 in dorsal telencephalon (Rapgef2-cKO) resulted in the formation of an ectopic cortical mass (ECM) resembling that of subcortical band heterotopia...
May 2016: ENeuro
Lijun Wang, Xiaoke Shang, Qiu Qiu, Rong Lu, Shuna Xiao, Dingyang Li, Jie Yu, Changdong Zhang, Cheng Xia, Hongmei Zhou, Gangcheng Zhang
Postoperative junctional ectopic tachycardia (JET) is a narrow complex tachycardia and most frequently occurs during and after surgical repair of certain types of congenital heart defects. Postoperative junctional ectopic tachycardia may produce unfavorable hemodynamics that prolongs stays in the cardiac intensive care unit and hospital, prolongs time on a ventilator, and occasionally requires the use of extracorporeal membrane oxygenation (ECMO) as rescue therapy. The present report describes a rare case of late-onset postoperative junctional ectopic tachycardia, which occurred 13 days after the deployment of a perimembranous ventricular septal defect (PmVSD) occluder in a 17-year-old female teenager...
July 27, 2016: International Heart Journal
Jan Novak, Alessandro Zorzi, Silvia Castelletti, Antonis Pantasis, Ilaria Rigato, Domenico Corrado, William Mckenna, Pier D Lambiase
AIMS: The differentiation between idiopathic right ventricular outflow tract (RVOT) arrhythmias and early arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging. We aimed to assess whether QRS morphological features and coupling interval of ventricular ectopic beats (VEBs) can improve differentiation between the two conditions. METHODS AND RESULTS: Twenty desmosomal-gene mutation carriers (13 females, mean age 43 years) with no or mild ARVC phenotypic expression and 33 age- and sex-matched subjects with idiopathic RVOT arrhythmias were studied...
June 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Andreas Müssigbrodt, Helge Knopp, Timm Seewöster, Sebastian Hilbert, Johannes Lucas, Kerstin Nowotnick, Borislav Dinov, Gerhard Hindricks, Arash Arya, Sergio Richter
AIMS: Supraventricular tachycardia, mistakenly diagnosed as ventricular tachycardia, may lead to inappropriate ICD therapy. Inappropriate ICD therapy associates with increased morbidity and mortality. A reduction of inappropriate therapy is therefore desired. METHODS AND RESULTS: We present three different cases that beautifully illustrate the diagnostic possibilities of stored electrograms. Initial differential diagnoses in all three patients included ventricular tachycardia, focal atrial tachycardia, atrio-ventricular re-entry tachycardia, and atrio-ventricular nodal re-entry tachycardia...
June 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Bastian Schneider, Johannes Holfeld, Michael Grimm, Ludwig Müller
Intrapericardial left-sided ectopic thyroid tissue is a rare entity. We report a 47-year old female patient with an intrapericardial mass mounting the left atrial wall. Two prominent vessels, both originating from the left circumflex artery (LCX), supplied the tumour. Owing to the compression of the left atrium and the left upper pulmonary vein, the patient was highly symptomatic with exertional dyspnoea and ventricular extrasystoles. Histopathological examination showed regressive thyroid adenoma with no signs of malignancy...
October 2016: Interactive Cardiovascular and Thoracic Surgery
Mariana Argenziano, Gisela Tiscornia, Rosalia Moretta, Leonardo Casal, Constanza Potilinski, Carlos Amorena, Eduardo Garcia Gras
In most species androgens shorten the cardiac action potential and reduce the risk of afterdepolarizations. Despite the central role of the rat model in physiological studies, the effects of androgens on the rat heart are still inconclusive. We therefore performed electrophysiological studies on the perfused rat right ventricular free wall. We found a correlation between androgenic activity and a propensity to generate ventricular ectopic action potentials. We also found that the testosterone treatment increased action potential duration at 90 % of repolarization (APD90), while androgenic inhibition increased the time to peak and decreased APD90...
May 30, 2016: Journal of Physiological Sciences: JPS
Xiaobin Han, L Darryl Quarles
PURPOSE OF REVIEW: This review examines the role of fibroblast growth factor-23 (FGF-23) in mineral metabolism, innate immunity and adverse cardiovascular outcomes. RECENT FINDINGS: FGF-23, produced by osteocytes in bone, activates FGFR/α-Klotho (α-Kl) complexes in the kidney. The resulting bone-kidney axis coordinates renal phosphate reabsorption with bone mineralization, and creates a counter-regulatory feedback loop to prevent vitamin D toxicity. FGF-23 acts to counter-regulate the effects of vitamin D on innate immunity and cardiovascular responses...
July 2016: Current Opinion in Nephrology and Hypertension
Jana-Katharina Dieks, Sophia Klehs, Matthias J Müller, Thomas Paul, Ulrich Krause
BACKGROUND: Treatment of congenital junctional ectopic tachycardia (JET) is often challenging. In the majority of patients affected, a combination of ≥2 antiarrhythmic drugs is required for JET control. OBJECTIVE: The purpose of this study was to assess the efficacy and safety of adjunctive ivabradine therapy for pediatric congenital JET. METHODS: Since January 2015, 5 consecutive patients aged 10 days to 3.5 years (median 8 weeks) were treated with adjunctive ivabradine for congenital JET...
June 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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