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https://www.readbyqxmd.com/read/27920482/hepatitis-c-virus-therapy-with-peg-interferon-and-ribavirin-in-myanmar-a-resource-constrained-country
#1
Naomi Khaing Than Hlaing, Debolina Banerjee, Robert Mitrani, Soe Htet Arker, Kyaw San Win, Nyan Lin Tun, Zaw Thant, Khin Maung Win, K Rajender Reddy
AIM: To investigate peg-interferon (peg-IFN) and ribavirin (RBV) therapy in Myanmar and to predict sustained virologic response (SVR). METHODS: This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN alpha-2a (180 μg/wk) or alpha-2b (50 to 100 μg as a weight-based dose) and RBV as a weight-based dose (15 mg/kg/d). Treatment duration was 48 wk for genotypes 1 and 6, 24 wk for genotype 2, and 24 or 48 wk for genotype 3 based on rapid virologic response (RVR)...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27920241/effectiveness-of-mindfulness-intervention-on-psychological-behaviors-among-adolescents-with-parental-hiv-infection-a-group-randomized-controlled-trial
#2
Myo-Myo Mon, Tippawan Liabsuetrakul, Kyaw-Min Htut
This study aims to identify the effectiveness of mindfulness intervention on the psychological behaviors of adolescents with parental HIV infection and its associated factors in Myanmar. A total of 80 adolescents from 2 intervention townships and 80 adolescents from 2 control townships were enrolled in a group randomized controlled trial with assessments at baseline and 6 months follow-up. The mindfulness intervention involved monthly group sessions for 3 consecutive months led by an experienced mindfulness trainer...
November 2016: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/27909580/burden-of-neisseria-meningitidis-infections-in-china-a-systematic-review-and-meta-analysis
#3
Yaowen Zhang, Dong Wei, Xinzhen Guo, Mai Han, Lichao Yuan, Moe H Kyaw
BACKGROUND: Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia in children and young adults worldwide. The disease burden associated with N. meningitidis infections has not been systematically assessed in China. Therefore, we undertook this study to determine the burden of meningococcal disease in China. METHOD: We performed a systematic review and meta-analysis of articles on N. meningitidis incidence, carriage, seroprevalence and mortality rates in China by searching the Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed for publications from January 2005 to Aug 2015...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27902293/colwellia-marinimaniae-sp-nov-a-hyperpiezophilic-species-isolated-from-an-amphipod-within-the-challenger-deep-mariana-trench
#4
Masataka Kusube, Than S Kyaw, Kumiko Tanikawa, Roger A Chastain, Kevin Hardy, James Cameron, Douglas H Bartlett
An obligately piezophilic strain was isolated from an amphipod crustacean obtained in the Challenger Deep region of the Mariana Trench during the DEEPSEA CHALLENGE expedition. The strain, MTCD1T, grew at extremely high hydrostatic pressures, with a growth range of 80-140 MPa (optimum: 120 MPa) at 6°C. Phylogenetic analyses based on the 16S rRNA gene sequence indicates that it is closely affiliated with the genus Colwellia. Comparative 16S rRNA gene sequence analyses revealed 95.7%, 95.5%, and 95.2% similarity to Colwellia maris ABE-1T, Colwellia piezophila Y233GT, and Colwellia psychrerythraea 34HT, respectively...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27882964/bacteria-establish-an-aqueous-living-space-in-plants-crucial-for-virulence
#5
Xiu-Fang Xin, Kinya Nomura, Kyaw Aung, André C Velásquez, Jian Yao, Freddy Boutrot, Jeff H Chang, Cyril Zipfel, Sheng Yang He
High humidity has a strong influence on the development of numerous diseases affecting the above-ground parts of plants (the phyllosphere) in crop fields and natural ecosystems, but the molecular basis of this humidity effect is not understood. Previous studies have emphasized immune suppression as a key step in bacterial pathogenesis. Here we show that humidity-dependent, pathogen-driven establishment of an aqueous intercellular space (apoplast) is another important step in bacterial infection of the phyllosphere...
November 23, 2016: Nature
https://www.readbyqxmd.com/read/27852180/young-onset-colorectal-cancer-in-the-asia-pacific-region
#6
Moe Kyaw, Joseph Jy Sung
No abstract text is available yet for this article.
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27837488/subcellular-localization-of-pseudomonas-syringae-pv-tomato-effector-proteins-in-plants
#7
Kyaw Aung, Xiufang Xin, Christy Mecey, Sheng Yang He
Animal and plant pathogenic bacteria use type III secretion systems to translocate proteinaceous effectors to subvert innate immunity of their host organisms. Type III secretion/effector systems are a crucial pathogenicity factor in many bacterial pathogens of plants and animals. Pseudomonas syringae pv. tomato (Pst) DC3000 injects a total of 36 protein effectors that target a variety of host proteins. Studies of a subset of Pst DC3000 effectors demonstrated that bacterial effectors, once inside the host cell, are localized to different subcellular compartments, including plasma membrane, cytoplasm, mitochondria, chloroplast, and Trans-Golgi network, to carry out their virulence functions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27836313/cancer-immunotherapy-induced-posterior-reversible-encephalopathy-syndrome-in-an-emergency-department
#8
Myint Aung Win, Kyaw Zin Thein, Sai-Ching Jim Yeung
No abstract text is available yet for this article.
October 29, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27829818/archaea-in-natural-and-impacted-brazilian-environments
#9
REVIEW
Thiago Rodrigues, Aline Belmok, Elisa Catão, Cynthia Maria Kyaw
In recent years, archaeal diversity surveys have received increasing attention. Brazil is a country known for its natural diversity and variety of biomes, which makes it an interesting sampling site for such studies. However, archaeal communities in natural and impacted Brazilian environments have only recently been investigated. In this review, based on a search on the PubMed database on the last week of April 2016, we present and discuss the results obtained in the 51 studies retrieved, focusing on archaeal communities in water, sediments, and soils of different Brazilian environments...
2016: Archaea: An International Microbiological Journal
https://www.readbyqxmd.com/read/27819414/a-6-point-tacs-score-predicts-in-hospital-mortality-following-total-anterior-circulation-stroke
#10
Adrian D Wood, Nicholas D Gollop, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, Marcus D Flather, John F Potter, Phyo Kyaw Myint
BACKGROUND AND PURPOSE: Little is known about the factors associated with in-hospital mortality following total anterior circulation stroke (TACS). We examined the characteristics and comorbidity data for TACS patients in relation to in-hospital mortality with the aim of developing a simple clinical rule for predicting the acute mortality outcome in TACS. METHODS: A routine data registry of one regional hospital in the UK was analyzed. The subjects were 2,971 stroke patients with TACS (82% ischemic; median age=81 years, interquartile age range=74-86 years) admitted between 1996 and 2012...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27814506/ebola-virus-glycoprotein-with-increased-infectivity-dominated-the-2013-2016-epidemic
#11
William E Diehl, Aaron E Lin, Nathan D Grubaugh, Luiz Max Carvalho, Kyusik Kim, Pyae Phyo Kyawe, Sean M McCauley, Elisa Donnard, Alper Kucukural, Patrick McDonel, Stephen F Schaffner, Manuel Garber, Andrew Rambaut, Kristian G Andersen, Pardis C Sabeti, Jeremy Luban
The magnitude of the 2013-2016 Ebola virus disease (EVD) epidemic enabled an unprecedented number of viral mutations to occur over successive human-to-human transmission events, increasing the probability that adaptation to the human host occurred during the outbreak. We investigated one nonsynonymous mutation, Ebola virus (EBOV) glycoprotein (GP) mutant A82V, for its effect on viral infectivity. This mutation, located at the NPC1-binding site on EBOV GP, occurred early in the 2013-2016 outbreak and rose to high frequency...
November 3, 2016: Cell
https://www.readbyqxmd.com/read/27809356/the-effect-of-growth-hormone-replacement-on-the-thyroid-axis-in-patients-with-hypopituitarism-in-vivo-and-ex-vivo-studies
#12
Nigel Glynn, Helena Kenny, Leah Quisenberry, David J Halsall, Paul Cook, Tommy Kyaw Tun, John H McDermott, Diarmuid Smith, Christopher J Thompson, Donal J O'Gorman, Anita Boelen, Joaquin Lado-Abeal, Amar Agha
OBJECTIVE: Alterations in the hypothalamo-pituitary-thyroid axis have been reported following growth hormone (GH) replacement. The aim was examine the relationship between changes in serum concentration of thyroid hormones and deiodinase activity in subcutaneous adipose tissue, before and after GH replacement. DESIGN: A prospective, observational study of patients receiving GH replacement as part of routine clinical care. PATIENTS: Twenty adult hypopituitary men...
November 3, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27793806/important-factors-in-predicting-mortality-outcome-from-stroke-findings-from-the-anglia-stroke-clinical-network-evaluation-study
#13
Phyo Kyaw Myint, Max O Bachmann, Yoon Kong Loke, Stanley D Musgrave, Gill M Price, Rachel Hale, Anthony Kneale Metcalf, David A Turner, Diana J Day, Elizabeth A Warburton, John F Potter
BACKGROUND: although variation in stroke service provision and outcomes have been previously investigated, it is less well known what service characteristics are associated with reduced short- and medium-term mortality. METHODS: data from a prospective multicentre study (2009-12) in eight acute regional NHS trusts with a catchment population of about 2.6 million were used to examine the prognostic value of patient-related factors and service characteristics on stroke mortality outcome at 7, 30 and 365 days post stroke, and time to death within 1 year...
October 28, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27778102/genomic-skimming-for-identification-of-medium-highly-abundant-transposable-elements-in-arundo-donax-and-arundo-plinii
#14
Aung Kyaw Lwin, Edoardo Bertolini, Mario Enrico Pè, Andrea Zuccolo
Transposable elements (TEs) are the most abundant genetic material for almost all eukaryotic genomes. Their effects on the host genomes range from an extensive size variation to the regulation of gene expression, altering gene function and creating new genes. Because of TEs pivotal contribute to the host genome structure and regulation, their identification and characterization provide a wealth of useful data for gaining an in-depth understanding of host genome functioning. The giant reed (Arundo donax) is a perennial rhizomatous C3 grass, octadecaploid, with an estimated nuclear genome size of 2744 Mbp...
October 24, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27776514/optimal-health-and-disease-management-using-spatial-uncertainty-a-geographic-characterization-of-emergent-artemisinin-resistant-plasmodium-falciparum-distributions-in-southeast-asia
#15
Eric P M Grist, Jennifer A Flegg, Georgina Humphreys, Ignacio Suay Mas, Tim J C Anderson, Elizabeth A Ashley, Nicholas P J Day, Mehul Dhorda, Arjen M Dondorp, M Abul Faiz, Peter W Gething, Tran T Hien, Tin M Hlaing, Mallika Imwong, Jean-Marie Kindermans, Richard J Maude, Mayfong Mayxay, Marina McDew-White, Didier Menard, Shalini Nair, Francois Nosten, Paul N Newton, Ric N Price, Sasithon Pukrittayakamee, Shannon Takala-Harrison, Frank Smithuis, Nhien T Nguyen, Kyaw M Tun, Nicholas J White, Benoit Witkowski, Charles J Woodrow, Rick M Fairhurst, Carol Hopkins Sibley, Philippe J Guerin
BACKGROUND: Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here we propose a generic 'smart surveillance' methodology to identify optimal candidate sites for future sampling and thus map the distribution of artemisinin resistance most efficiently. METHODS: The approach uses the 'uncertainty' map generated iteratively by a geostatistical model to determine optimal locations for subsequent sampling...
October 24, 2016: International Journal of Health Geographics
https://www.readbyqxmd.com/read/27772860/elevated-beta-hcg-in-a-non-pregnant-woman-also-consider-lung-adenocarcinoma-a-case-report
#16
Zaid Househ, Kyaw Lynnhtun, Amit Kapur, Philip Clingan
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27771791/the-molecular-epidemiological-study-of-bovine-leukemia-virus-infection-in-myanmar-cattle
#17
Meripet Polat, Hla Hla Moe, Takeshi Shimogiri, Kyaw Kyaw Moe, Shin-Nosuke Takeshima, Yoko Aida
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle. BLV infects cattle worldwide and affects both health status and productivity. However, no studies have examined the distribution of BLV in Myanmar, and the genetic characteristics of Myanmar BLV strains are unknown. Therefore, the aim of this study was to detect BLV infection in Myanmar and examine genetic variability. Blood samples were obtained from 66 cattle from different farms in four townships of the Nay Pyi Taw Union Territory of central Myanmar...
October 22, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27767905/group-b-streptococcus-sequence-type-283-disease-linked-to-consumption-of-raw-fish-singapore
#18
Priyanka Rajendram, Win Mar Kyaw, Yee Sin Leo, Hanley Ho, Wen Kai Chen, Raymond Lin, De Partha Pratim, Hishamuddin Badaruddin, Brenda Ang, Timothy Barkham, Angela Chow
An outbreak of invasive group B Streptococcus (GBS) disease occurred in Singapore in mid-2015. We conducted a case-control study of 22 adults with invasive GBS infections during June 21-November 21, 2015. Consumption of raw fish was strongly associated with invasive sequence type 283 infections, but not with non-sequence type 283 infections.
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27759110/plasmodium-vivax-gpi-anchored-micronemal-antigen-pvgama-binds-human-erythrocytes-independent-of-duffy-antigen-status
#19
Yang Cheng, Feng Lu, Bo Wang, Jian Li, Jin-Hee Han, Daisuke Ito, Deok-Hoon Kong, Lubin Jiang, Jian Wu, Kwon-Soo Ha, Eizo Takashima, Jetsumon Sattabongkot, Jun Cao, Myat Htut Nyunt, Myat Phone Kyaw, Sanjay A Desai, Louis H Miller, Takafumi Tsuboi, Eun-Taek Han
Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections in Duffy-negative individuals, suggesting that the parasite may utilize alternative receptor-ligand pairs to complete the erythrocyte invasion. Here, we identified and characterized a novel parasite ligand, Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA), that bound human erythrocytes regardless of Duffy antigen status...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27756394/malaria-incidence-in-myanmar-2005-2014-steady-but-fragile-progress-towards-elimination
#20
Thet Thet Mu, Aye Aye Sein, Tint Tint Kyi, Myo Min, Ne Myo Aung, Nicholas M Anstey, Myat Phone Kyaw, Chit Soe, Mar Mar Kyi, Josh Hanson
BACKGROUND: There has been an impressive recent reduction in the global incidence of malaria, but the development of artemisinin resistance in the Greater Mekong Region threatens this progress. Increasing artemisinin resistance is particularly important in Myanmar, as it is the country in the Greater Mekong Region with the greatest malaria burden. If malaria is to be eliminated in the region, it is essential to define the spatial and temporal epidemiology of the disease in Myanmar to inform control strategies optimally...
October 18, 2016: Malaria Journal
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