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https://www.readbyqxmd.com/read/29158371/perception-of-curability-among-advanced-cancer-patients-an-international-collaborative-study
#1
Sriram Yennurajalingam, Luis Fernando Rodrigues, Omar Shamieh, Colombe Tricou, Marilène Filbet, Kyaw Naing, Akhileshwaran Ramaswamy, Pedro Emilio Perez-Cruz, Mary Jocelyn S Bautista, Sofia Bunge, Mary Ann Muckaden, Vikash Sewram, Sarah Fakrooden, Antonio Tejedor Noguera, Shobha S Rao, Diane Liu, Minjeong Park, Janet L Williams, Zhanni Lu, Hilda Cantu, David Hui, Suresh K Reddy, Eduardo Bruera
BACKGROUND: There are limited data on illness understanding and perception of cure among advanced cancer patients around the world. The aim of the study was to determine the frequency and factors associated with inaccurate perception of curability among advanced cancer patients receiving palliative care across the globe. MATERIALS AND METHODS: Secondary analysis of a study to understand the core concepts in end-of-life care among advanced cancer patients receiving palliative care from 11 countries across the world...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29151457/anatomical-profile-of-the-mesial-root-of-the-burmese-mandibular-first-molar-with-vertucci-s-type-iv-canal-configuration
#2
Maung Maung Kyaw Moe, Jung-Hong Ha, Myoung-Uk Jin, Young-Kyung Kim, Sung Kyo Kim
This study evaluated the anatomical profile of the mesial root canals of the Burmese mandibular first molar with Vertucci's type IV canal configuration (VT4) using microcomputed tomography analysis. Seventy-five mesial roots of extracted mandibular first molars were scanned and evaluated. Fourteen middle mesial canals (MMCs) were observed in the specimens; each specimen had an average of 1.63 lateral canals and 3.77 apical foramina. The lateral canals arising from the mesiobuccal canal, mesiolingual canal, MMC, and isthmus terminated at an average distance of 0...
November 17, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29148967/group-b-streptococcus-infections-caused-by-improper-sourcing-and-handling-of-fish-for-raw-consumption-singapore-2015-2016
#3
Man L Chau, Swaine L Chen, Min Yap, Sri H P Hartantyo, Paul K T Chiew, Charlene J Fernandez, Wai K Wong, Rockey K Fong, Wei L Tan, Brian Z Y Tan, Youming Ng, Kyaw T Aung, Kurosh S Mehershahi, Christopher Goh, Joanne S L Kang, Timothy Barkham, Adeline O K Leong, Ramona A Gutiérrez, Lee C Ng
We assessed microbial safety and quality of raw fish sold in Singapore during 2015-2016 to complement epidemiologic findings for an outbreak of infection with group B Streptococcus serotype III sequence type (ST) 283 associated with raw fish consumption. Fish-associated group B Streptococcus ST283 strains included strains nearly identical (0-2 single-nucleotide polymorphisms) with the human outbreak strain, as well as strains in another distinct ST283 clade (57-71 single-nucleotide polymorphisms). Our investigations highlight the risk for contamination of freshwater fish (which are handled and distributed separately from saltwater fish sold as sashimi) and the need for improved hygienic handling of all fish for raw consumption...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29148371/diagnostic-accuracy-of-parameters-for-zika-and-dengue-virus-infections-singapore
#4
Hanley J Ho, Joshua G X Wong, Win Mar Kyaw, David C Lye, Yee Sin Leo, Angela Chow
Singapore experienced its first documented Zika virus outbreak in 2016. We identified clinical and laboratory parameters that increase the probability for Zika or dengue virus infection. Early during the illness, combinations of key parameters obtained through clinical assessment and hematologic tests can help distinguish between these infections.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29146640/lipid-profiles-and-determinants-of-total-cholesterol-and-hypercholesterolaemia-among-25-74-year-old-urban-and-rural-citizens-of-the-yangon-region-myanmar-a-cross-sectional-study
#5
Aung Soe Htet, Marte Karoline Kjøllesdal, Wai Phyo Aung, Aye Nyein Moe Myint, Win Thuzar Aye, Myint Myint Wai, Than Than Nu, Ei Mon Hla, Pyone Pyone Soe, Nan Wut Yi Tun, Naw Angela, Mya Mya Khaing, Aung Kyaw Htoo, Soe Tun, Pai Thitsar, Theeoo Lwin, San San Wai, Thi Thi Aung, Khin Aye Thant, Wai Wai Aung Po, Seng Taung Gauzam, Tun Tun Naing, Thet Min Tun, Khin San Myint, Kyi Kyi Oo, Nang Kee Myu Mang, Soe Moe Naing, Ko Ko Zaw, Marius Bergsmark Bjertness, Lhamo Yangchen Sherpa, Win Myint Oo, Hein Stigum, Espen Bjertness
OBJECTIVE: The first is to estimate the prevalence of dyslipidaemia (hypercholesterolaemia, hypertriglyceridaemia, high low-density lipoprotein (LDL) level and low high-density lipoprotein (HDL) level), as well as the mean levels of total cholesterol, triglyceride, LDL and HDL, in the urban and rural Yangon Region, Myanmar. The second is to investigate the association between urban-rural location and total cholesterol. DESIGN: Two cross-sectional studies using the WHO STEPS methodology...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29121931/individual-and-household-characteristics-of-persons-with-plasmodium-falciparum-malaria-in-sites-with-varying-endemicities-in-kinshasa-province-democratic-republic-of-the-congo
#6
Melchior Kashamuka Mwandagalirwa, Lauren Levitz, Kyaw L Thwai, Jonathan B Parr, Varun Goel, Mark Janko, Antoinette Tshefu, Michael Emch, Steven R Meshnick, Margaret Carrel
BACKGROUND: The Democratic Republic of the Congo (DRC) bears a large share of global malaria burden despite efforts to control and eliminate the disease. More detailed understanding of individual and household level characteristics associated with malaria are needed, as is an understanding of how these characteristics vary spatiotemporally and across different community-level malaria endemicities. An ongoing study in Kinshasa Province is designed to address gaps in prior malaria surveillance in the DRC by monitoring malaria across seasons, age groups and in high and low malaria sites...
November 9, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29121661/high-prevalence-of-non-communicable-diseases-and-associated-risk-factors-amongst-adults-living-with-hiv-in-cambodia
#7
Pheak Chhoun, Sovannary Tuot, Anthony D Harries, Nang Thu Thu Kyaw, Khuondyla Pal, Phalkun Mun, Carrine Brody, Gitau Mburu, Siyan Yi
BACKGROUND: With rapid expansion of antiretroviral therapy for HIV, there are rising life expectancies among people living with HIV. As a result, co-morbidity from non-communicable diseases in those living and aging with HIV is increasingly being reported. Published data on this issue have been limited in Cambodia. The aim of this study was to determine the prevalence of diabetes mellitus, hypertension and hypercholesterolemia and associated risk factors in adults living with HIV in Cambodia...
2017: PloS One
https://www.readbyqxmd.com/read/29115910/factors-associated-with-long-turnaround-time-for-early-infant-diagnosis-of-hiv-in-myanmar
#8
Soe Thiha, Hemant Deepak Shewade, Sairu Philip, Thet Ko Aung, Nang Thu Thu Kyaw, Myo Minn Oo, Khine Wut Yee Kyaw, May Wint War, Htun Nyunt Oo
BACKGROUND: A previous review of early infant diagnosis (EID) using polymerase chain reaction technology (PCR) under integrated HIV care (IHC) program in Myanmar revealed a low uptake of timely (within 6 to 8 weeks of babies' age) EID and a long turnaround time (TAT) of receiving results. OBJECTIVE: This study aimed to determine the proportion and factors associated with the composite outcome of a long TAT (≥7 weeks; from sample collection to receipt of result by mother) or nonreceipt of result among HIV-exposed babies whose blood samples were collected for PCR at <9 months of age under the IHC program, Myanmar (2013-15)...
2017: Global Health Action
https://www.readbyqxmd.com/read/29106439/increased-diastolic-blood-pressure-is-associated-with-mri-biomarkers-of-dementia-related-brain-pathology-in-normative-ageing
#9
Christopher J McNeil, Phyo Kyaw Myint, Anca-Larisa Sandu, John F Potter, Roger Staff, Lawrence J Whalley, Alison D Murray
Background: hypertension is a risk for brain ageing, but the mechanisms underlying this effect remain unclear. Magnetic resonance imaging (MRI) detected biomarkers of brain ageing include white matter hyperintensities (WMHs), a marker of cerebrovascular disease, and hippocampal volume, a marker of Alzheimer's disease pathology. Objective: to examine relationships between blood pressure (BP) components and brain pathology in older adults. Subjects: two hundred and twenty-seven members of the Aberdeen 1936 Birth Cohort between ages 64 and 68 years...
July 4, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29060859/statistical-modeling-on-motion-trajectories-for-robotic-laparoscopic-surgery
#10
Tao Yang, Weimin Huang, Kyaw Kyar Toe
Learning by demonstration enables a robot to learn and perform tasks from kinesthetic demonstrations. Gaussian mixture method with constraints is applied in this work to model the motion using its trajectories and enable a robot to learn motion skills for a simple surgical task with specific requirement. Tissue dividing experiments are demonstrated on a robotic surgical simulation platform to collect motion trajectories. The demonstrations are modelled using Gaussian Mixture Model. Constraints are also imposed onto the motion model to suit the specific requirements for carrying out the surgical task on a virtual patient...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060090/fast-segmentation-and-modeling-of-hepatic-components-for-the-planning-of-robot-assisted-liver-tumor-ablation
#11
Jiayin Zhou, Yanling Chi, Weimin Huang, Kyaw Kyar Toe, Chee Kong Chui, Stephen K Y Chang
Segmentation and modeling of hepatic components from pre-operative images is very important for treatment planning and guidance in robot-assisted liver tumor ablation. An in-house developed system for hepatic component segmentation and modeling using CT data is presented in this paper. This system includes gross liver segmentation by a 3D mesh deformation model, liver vasculature segmentation by a vessel context-based voting and grouping method, liver tumor segmentation by a support vector machine framework, and other segmentation/modeling tool...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29046758/coronary-artery-ectasia-presenting-with-acute-inferior-wall-myocardial-infarction-in-a-young-adult
#12
Htun Latt, Sammy Aung, Kyaw Kyaw, Richard Seher
Coronary artery ectasia (CAE), a variant of coronary artery anomalies, is a rare clinical entity. Although atherosclerotic coronary artery disease (CAD) is the most common cause of acute coronary syndrome (ACS), CAE also conveys a relatively high risk for potentially life-threatening cardiac events. We report a case of a 35-year-old male with two-vessel CAE, who presented with acute inferior wall ST election myocardial infarction (STEMI). After initiating medical therapy including bivalirudin, emergent percutaneous coronary intervention (PCI) with stenting of postero-lateral branch of right coronary artery (RCA) was performed...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29039864/effects-of-pulsed-laser-irradiation-on-gold-coated-silver-nanoplates-and-their-antibacterial-activity
#13
Kaung Kyaw, Hiroaki Ichimaru, Takayuki Kawagoe, Mitsuhiro Terakawa, Yuta Miyazawa, Daigou Mizoguchi, Masayuki Tsushida, Takuro Niidome
Gold-coated silver nanoplates, when subjected to pulsed laser irradiation, changed their shape from triangular to spherical, accompanied by a shift of their extinction spectra. The simple single crystal structure of the silver nanoplates changed to multiple small crystal domains. The ratio of silver to gold of the particles also changed from 22 : 1 to 4.5 : 1, enabling more silver to be released. As a result, the antibacterial activity of the gold-coated silver nanoplates was significantly increased after pulsed laser irradiation...
October 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/29038513/anomalous-kondo-resonance-mediated-by-semiconducting-graphene-nanoribbons-in-a-molecular-heterostructure
#14
Yang Li, Anh T Ngo, Andrew DiLullo, Kyaw Zin Latt, Heath Kersell, Brandon Fisher, Peter Zapol, Sergio E Ulloa, Saw-Wai Hla
Kondo resonances in heterostructures formed by magnetic molecules on a metal require free host electrons to interact with the molecular spin and create delicate many-body states. Unlike graphene, semiconducting graphene nanoribbons do not have free electrons due to their large bandgaps, and thus they should electronically decouple molecules from the metal substrate. Here, we observe unusually well-defined Kondo resonances in magnetic molecules separated from a gold surface by graphene nanoribbons in vertically stacked heterostructures...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29030915/political-transition-and-emergent-forest-conservation-issues-in-myanmar
#15
REVIEW
Graham W Prescott, William J Sutherland, Daniel Aguirre, Matthew Baird, Vicky Bowman, Jake Brunner, Grant M Connette, Martin Cosier, David Dapice, Jose Don T De Alban, Alex Diment, Julia Fogerite, Jefferson Fox, Win Hlaing, Saw Htun, Jack Hurd, Katherine LaJeunesse Connette, Felicia Lasmana, Cheng Ling Lim, Antony Lynam, Aye Chan Maung, Benjamin McCarron, John F McCarthy, William J McShea, Frank Momberg, Myat Su Mon, Than Myint, Robert Oberndorf, Thaung Naing Oo, Jacob Phelps, Madhu Rao, Dietrich Schmidt-Vogt, Hugh Speechly, Oliver Springate-Baginski, Robert Steinmetz, Kirk Talbott, Maung Maung Than, Tint Lwin Thaung, Salai Cung Lian Thawng, Kyaw Min Thein, Shwe Thein, Robert Tizard, Tony Whitten, Guy Williams, Trevor Wilson, Kevin Woods, Alan D Ziegler, Michal Zrust, Edward L Webb
Political and economic transitions have had substantial impacts on forest conservation. Where transitions are underway or anticipated, historical precedent and methods for systematically assessing future trends should be used to anticipate likely threats to forest conservation and design appropriate and prescient policy measures to counteract them. Myanmar is transitioning from an authoritarian, centralized state with a highly regulated economy to a more decentralized and economically liberal democracy and is working to end a long-running civil war...
October 14, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29024310/influence-of-metabolic-syndrome-and-race-on-the-relationship-between-intensive-blood-pressure-control-and-cardiovascular-outcomes-in-the-sprint-cohort
#16
Kathleen Dungan, Timothy E Craven, Kyaw Soe, Jackson T Wright, Jan Basile, William E Haley, Nancy R Kressin, Uzma Rani, Leonardo Tamariz, Jeff Whittle, Alan Wiggers, Kwame Osei
AIMS: To determine whether baseline metabolic syndrome (MetS) modifies the effect of intensive blood pressure control on cardiovascular (CV) outcomes, and whether the effects varied by race/ethnicity. METHODS: We performed post hoc analyses among non-Hispanic black, non-hispanic white and Hispanic participants, with and without MetS, in the Systolic Blood Pressure Intervention Trial (SPRINT), who were randomized to a systolic blood pressure (SBP) target of <120 mm Hg (intensive group, N = 4544) or an SBP target of <140 mm Hg (standard group, N = 4553)...
October 12, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28993605/a-case-of-diffuse-alveolar-hemorrhage-as-a-possible-complication-of-bivalirudin-therapy
#17
Htun Latt, Sammy Aung, Kyaw Kyaw, Thein Tun Aung, Chanwit Roongsritong
BACKGROUND Diffuse alveolar hemorrhage (DAH) is a rare but potentially fatal complication of anticoagulant or antiplatelet therapy. Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI). CASE REPORT We report a case of severe DAH, possibly related to bivalirudin use, in a 61-year-old patient undergoing coronary intervention. The patient had presented with an out-of-hospital cardiac arrest due to acute ST elevation myocardial infarction (STEMI). During the coronary intervention, shortly after receiving bivalirudin, the patient started having frank bleeding from the endotracheal tube and developed hemodynamic compromise...
October 10, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28970281/rna-binding-protein-ybx2-regulates-rna-stability-during-cold-induced-brown-fat-activation
#18
Dan Xu, Shaohai Xu, Aung Maung Maung Kyaw, Yen Ching Lim, Sook Yoong Chia, Diana Teh Chee Siang, Juan R Alvarez-Dominguez, Peng Chen, Melvin Khee-Shing Leow, Lei Sun
Recent years have seen an upsurge of interest on brown adipose tissue (BAT) to combat the epidemic of obesity and diabetes. How its development and activation are regulated at the post-transcriptional level, however, has yet to be fully understood. RNA binding proteins (RBPs) lie in the center of post-transcriptional regulation. To systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation...
September 29, 2017: Diabetes
https://www.readbyqxmd.com/read/28961760/endoscopic-and-histologic-mucosal-healing-in-ulcerative-colitis-in-the-first-year-of-diagnosis-results-from-a-population-based-inception-cohort-from-six-countries-in-asia
#19
Choy May Leung, Whitney Tang, Kyaw Moe, Gani Niamul, Satimai Aniwan, Julajak Limsrivilai, Yu-Fang Wang, Qin Ouyang, Marcellus Simadibrata, Murdani Abdullah, David E Ong, Hon Ho Yu, Jinwen Zhang, Jessica Ching, Justin C Wu, Francis K Chan, Joseph J Y Sung, Siew C Ng
Background and Aims: Mucosal healing is associated with improved long-term clinical outcomes in patients with ulcerative colitis. This population-based study assessed endoscopic and histologic mucosal healing within the first year of diagnosis. Methods: Consecutive patients diagnosed with ulcerative colitis from 6 countries in Asia were prospectively enrolled. Clinical demographics, blood markers and inflammatory activity were assessed at baseline. Mayo score and Nancy index were used to assess endoscopic and histologic activities, respectively...
July 26, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28959410/a-complex-stereochemical-relay-approach-to-the-antimalarial-alkaloid-ocimicide-a1-evidence-for-a-structural-revision
#20
Herman Nikolayevskiy, Maung Kyaw Moe Tun, Paul R Rablen, Choukri Ben Mamoun, Seth B Herzon
Ocimicide A1 (1) and the semisynthetic derivative ocimicide A2 (2) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant Plasmodium falciparum strains with IC50 values in the nanomolar and picomolar range, respectively. Members of this family have demonstrated radical cure in rhesus monkeys, without detectable toxicity, but their structure-function relationships and mechanism of action are unknown. Herein we describe a twelve-step synthesis of an advanced N-acylated pentacyclic precursor to the proposed structure of 1 (11% overall yield)...
July 1, 2017: Chemical Science
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