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https://www.readbyqxmd.com/read/28721036/prevalence-and-associated-factors-of-copd-among-aboriginal-peoples-in-canada-a-cross-sectional-study
#1
Yelena Bird, John Moraros, Razi Mahmood, Sarvenaz Esmaeelzadeh, Nway Mon Kyaw Soe
BACKGROUND: COPD among Aboriginal peoples in Canada is a major public health concern. This study was conducted in order to determine the prevalence and association between certain risk factors and COPD among the 35-year-old or older Aboriginal peoples in Canada. METHODS: This is a cross-sectional study. It uses data from Statistics Canada's Aboriginal Peoples Survey (APS), 2012. It consists of 8,117 self-identified Aboriginal peoples, aged 35 years old or older from all Canadian provinces and territories...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28713062/a-prospective-study-on-second-generation-colon-capsule-endoscopy-to-detect-mucosal-lesions-and-disease-activity-in-ulcerative-colitis-with-video
#2
Hai Yun Shi, Francis Kl Chan, Akira Higashimori, Moe Kyaw, Jessica Yl Ching, Heyson Ch Chan, Joey Ch Chan, Anthony Wh Chan, Kelvin Ly Lam, Raymond Sy Tang, Justin Cy Wu, Joseph Jy Sung, Siew C Ng
BACKGROUND & AIMS: Mucosal healing is the goal for ulcerative colitis (UC) therapy, but needs to be confirmed under colonoscopy. Colon capsule endoscopy (CCE) is a noninvasive technique for colon investigation. Our study investigated the accuracy of the second-generation CCE (CCE-2) to assess mucosal lesions and disease activity in UC. METHODS: In this prospective study, CCE-2 and conventional colonoscopy were performed on the same day. CCE-2 reviewers and colonoscopists used Mayo endoscopic subscore (MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) to assess disease activity, and were blinded to each other's findings...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28709653/set-point-manipulation-approach-towards-online-performance-improvement-in-existing-process-control-loops
#3
Ko Ko Htet Kyaw, Kok Kiong Tan
The majority of current industrial process control systems are based on PID control. However, in many of these systems, once the initial setup has been carried out, it is difficult to implement subsequent continuous improvements on the control performance without shutting down the production and disarming the overall system to retrofit alternative controllers. These measures to integrate additional instruments for allowing such flexibility incur heavy costs in terms of time and resources. In this paper, we propose an approach towards achieving the control adaptations which cannot be achieved easily with an existing closed-architectural system...
July 11, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28704318/interrelationships-between-3-keratoconic-cone-parameters
#4
Kyaw L Tu, Abdo K Tourkmani, Singaram Srinivas
PURPOSE: To find out the interrelationships between 3 parameters of the keratoconic cone. METHODS: A total of 101 keratoconic eyes of 58 patients were included in this retrospective case series study. A complete eye examination was performed. Kmax (K) and pachymetry at the thinnest point (T) were obtained from the Pentacam tomographer. The vertex to thinnest pachymetry distance (D for decentration) was calculated using trigonometry. Pearson correlation coefficients between T and D, between T and K, and between D and K were calculated...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28698666/modelling-person-to-person-transmission-in-an-enterovirus-a71-orally-infected-hamster-model-of-hand-foot-and-mouth-disease-and-encephalomyelitis
#5
Win Kyaw Phyu, Kien Chai Ong, Kum Thong Wong
Enterovirus A71 (EV-A71) causes hand-foot-and-mouth disease (HFMD), which may be complicated by fatal encephalomyelitis. Although fecal-oral or oral-oral routes are important in person-to-person transmission, how viral shedding and exposure may predispose individuals to infection remains unknown. We investigated person-to-person transmission by using a model of HFMD and encephalomyelitis based on EV-A71 oral infection of 2-week-old hamsters. Animals (index animals) infected with 10(4) 50% cell culture infective doses of virus uniformly developed severe disease four days post-infection (dpi), whereas littermate contacts developed severe disease after six to seven days of exposure to index animals...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28693552/chloroquine-efficacy-for-plasmodium-vivax-in-myanmar-in-populations-with-high-genetic-diversity-and-moderate-parasite-gene-flow
#6
Myo Win Htun, Nan Cho Nwe Mon, Khin Myo Aye, Chan Myae Hlaing, Myat Phone Kyaw, Irene Handayuni, Hidayat Trimarsanto, Dorina Bustos, Pascal Ringwald, Ric N Price, Sarah Auburn, Kamala Thriemer
BACKGROUND: Plasmodium vivax malaria remains a major public health burden in Myanmar. Resistance to chloroquine (CQ), the first-line treatment for P. vivax, has been reported in the country and has potential to undermine local control efforts. METHODS: Patients over 6 years of age with uncomplicated P. vivax mono-infection were enrolled into clinical efficacy studies in Myawaddy in 2014 and Kawthoung in 2012. Study participants received a standard dose of CQ (25 mg/kg over 3 days) followed by weekly review until day 28...
July 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28676097/genetic-diversity-of-plasmodium-falciparum-populations-in-southeast-and-western-myanmar
#7
Than Naing Soe, Yanrui Wu, Myo Win Tun, Xin Xu, Yue Hu, Yonghua Ruan, Aung Ye Naung Win, Myat Htut Nyunt, Nan Cho Nwe Mon, Kay Thwe Han, Khin Myo Aye, James Morris, Pincan Su, Zhaoqing Yang, Myat Phone Kyaw, Liwang Cui
BACKGROUND: The genetic diversity of malaria parasites reflects the complexity and size of the parasite populations. This study was designed to explore the genetic diversity of Plasmodium falciparum populations collected from two southeastern areas (Shwekyin and Myawaddy bordering Thailand) and one western area (Kyauktaw bordering Bangladesh) of Myanmar. METHODS: A total of 267 blood samples collected from patients with acute P. falciparum infections during 2009 and 2010 were used for genotyping at the merozoite surface protein 1 (Msp1), Msp2 and glutamate-rich protein (Glurp) loci...
July 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28669789/self-directed-interactive-video-based-instruction-versus-instructor-led-teaching-for-myanmar-house-surgeons-a-randomized-noninferiority-trial
#8
Albert Thein Lwin, Thein Lwin, Phyu Naing, Yee Oo, David Kidd, Marcelo Cerullo, Joshua Posen, Kyaw Hlaing, Gayane Yenokyan, Kyi Kyi Thinn, Zaw Wai Soe, Kent A Stevens
OBJECTIVE: To compare self-directed interactive video-based instruction (IVBI) with instructor-led teaching in the acquisition of basic surgical skills by House Surgeons at University of Medicine 1, Yangon. DESIGN: A prospective, 1:1 randomized controlled trial was conducted. Participants were randomized into 2 teaching arms: (1) self-directed IVBI or (2) instructor-led teaching. Self-directed IVBI participants were provided with a portable DVD player that could play, fast forward, rewind, and skip through skills modules...
June 29, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28659859/pre-stroke-modified-rankin-scale-evaluation-of-validity-prognostic-accuracy-and-association-with-treatment
#9
Terence J Quinn, Martin Taylor-Rowan, Aishah Coyte, Allan B Clark, Stanley D Musgrave, Anthony K Metcalf, Diana J Day, Max O Bachmann, Elizabeth A Warburton, John F Potter, Phyo Kyaw Myint
BACKGROUND AND PURPOSE: The modified Rankin Scale (mRS) was designed to measure poststroke recovery but is often used to describe pre-stroke disability. We sought to evaluate three aspects of pre-stroke mRS: validity as a measure of pre-stroke disability; prognostic accuracy and association of pre-stroke mRS scores, and process of care. METHODS: We used data from a large, UK clinical registry. For analysis of validity, we compared pre-stroke mRS against other markers of pre-stroke function (age, comorbidity index, care needs)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28658935/minimal-impact-by-antenatal-subpatent-p-falciparum-infections-on-delivery-outcomes-in-malawian-women-a-cohort-study
#10
Steve M Taylor, Mwayiwawo Madanitsa, Kyaw-Lay Thwai, Carole Khairallah, Linda Kalilani-Phiri, Anna M van Eijk, Victor Mwapasa, Feiko O Ter Kuile, Steven R Meshnick
Antenatal malaria screening with a rapid diagnostic test (RDT) and treatment only of RDT-positive women may potentially prevent low birthweight resulting from malaria. The consequences of subpatent antenatal infections below the detection limit of RDTs are incompletely understood. In Malawi, pregnant women of any gravidity were tested at each antenatal visit for P. falciparum using RDT and PCR and followed until delivery. Associations between antenatal infections and delivery outcomes were assessed with Poisson regression or ANOVA...
June 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28655767/three-distinct-3-methylcytidine-m3c-methyltransferases-modify-trna-and-mrna-in-mice-and-humans
#11
Luang Xu, Xinyu Liu, Na Sheng, Kyaw Soe Oo, Junxin Liang, Yok Hian Chionh, Juan Xu, Fuzhou Ye, Yong-Gui Gao, Peter C Dedon, Xin-Yuan Fu
Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. Despite a resurgent interest in these modifications, the biochemistry of 3-methylcytidine (m3C) formation in mammalian RNAs is still poorly understood. However, the recent discovery of trm141 as the second gene responsible for m3C presence in RNA in fission yeast raises the possibility that multiple enzymes are involved in m3C formation in mammals as well...
June 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28638298/uncertainty-of-myocardial-perfusion-imaging-in-chest-pain-risk-stratification
#12
Htoo Kyaw, Sivacharan Buddhavarapu, Joseph Abboud, Deepika Misra
BACKGROUND: Chest pain is a common presenting symptom in the emergency department (ED). Although the diagnostic workup for chest pain is well established, the best time to perform invasive cardiac catheterization in patients with low to moderate risk of coronary artery disease is still unclear, particularly if noninvasive tests such as the electrocardiogram (ECG) and nuclear myocardial perfusion scan show nonsignificant findings. CASE REPORT: We present the case of a 52-year-old female who presented to the ED with acute-onset chest pain that had started early in the morning while she was sleeping...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28638293/septic-embolic-stroke-resulting-from-staphylococcus-lugdunensis-endocarditis
#13
Htoo Kyaw, Atif Z Shaikh, Gokul Yaratha, Misra Deepika
BACKGROUND: Staphylococcus lugdunensis, a member of the coagulase-negative staphylococci (CoNS), has been recognized as a causal organism for infective endocarditis since the 1980s. Although most CoNS have an insidious and chronic nature, they are involved in a variety of systemic infections. S lugdunensis infective endocarditis is a rare entity but is as catastrophic as Staphylococcus aureus infective endocarditis and requires aggressive antibiotic therapy and, typically, valve replacement...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28607673/risk-factors-for-clostridium-difficile-infections-an-overview-of-the-evidence-base-and-challenges-in-data-synthesis
#14
Paul Eze, Evelyn Balsells, Moe H Kyaw, Harish Nair
BACKGROUND: Recognition of a broad spectrum of disease and development of Clostridium difficile infection (CDI) and recurrent CDI (rCDI) in populations previously considered to be at low risk has renewed attention on differences in the risk profile of patients. In the absence of primary prevention for CDI and limited treatment options, it is important to achieve a deep understanding of the multiple factors that influence the risk of developing CDI and rCDI. METHODS: We conducted a review of systematic reviews and meta-analyses on risk factors for CDI and rCDI published between 1990 and October 2016...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28603251/a-new-species-of-mud-snake-serpentes-homalopsidae-i-gyiophis-i-murphy-amp-voris-2014-from-myanmar-with-a-first-molecular-phylogenetic-assessment-of-the-genus
#15
Evan S H Quah, L Lee Grismer, Perry L Jr Wood, Myint Kyaw Thura, Thaw Zin, Htet Kyaw, Ngwe Lwin, Marta S Grismer, Matthew L Murdoch
A newly discovered species of homalopsid snake from the genus Gyiophis Murphy & Voris is described from the lowlands of Mawlamyine District in Mon state, southeastern Myanmar. Gyiophis salweenensis sp. nov. is presumed to be closely related to G. maculosa Blanford and G. vorisi Murphy based on the similarities in pholidosis and patterning but can be separated from G. maculosa by the shape of its first three dorsal scale rows that are square, ventral scale pattern that lacks a central spot, and a faint stripe on dorsal scale rows 1-4...
March 6, 2017: Zootaxa
https://www.readbyqxmd.com/read/28594295/long-term-outcomes-of-second-line-antiretroviral-treatment-in-an-adult-and-adolescent-cohort-in-myanmar
#16
Nang Thu Thu Kyaw, Ajay M V Kumar, Myo Minn Oo, Htun Nyunt Oo, Khine Wut Yee Kyaw, Soe Thiha, Thet Ko Aung, Than Win, Yin Yin Mon, Anthony D Harries
BACKGROUND: Myanmar has a high burden of Human Immunodeficiency Virus (HIV) and second-line antiretroviral treatment (ART) has been available since 2008 in the public health sector. However, there have been no published data about the outcomes of such patients until now. OBJECTIVE: To assess the treatment and programmatic outcomes and factors associated with unfavorable outcomes (treatment failure, death and loss to follow-up from care) among people living with HIV (aged ≥ 10 years) receiving protease inhibitor-based second-line ART under the Integrated HIV Care Program in Myanmar between October 2008 and June 2015...
2017: Global Health Action
https://www.readbyqxmd.com/read/28583119/surveillance-for-sulfadoxine-pyrimethamine-resistant-malaria-parasites-in-the-lake-and-southern-zones-tanzania-using-pooling-and-next-generation-sequencing
#17
Jeremiah M Ngondi, Deus S Ishengoma, Stephanie M Doctor, Kyaw L Thwai, Corinna Keeler, Sigsbert Mkude, Oresto M Munishi, Ritha A Willilo, Shabbir Lalji, Naomi Kaspar, Chonge Kitojo, Lynn A Paxton, Nicholas J Hathaway, Jeffrey A Bailey, Jonathan J Juliano, Steven R Meshnick, Julie Gutman
BACKGROUND: Malaria in pregnancy (MiP) remains a major public health challenge in areas of high malaria transmission. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended to prevent the adverse consequences of MiP. The effectiveness of SP for IPTp may be reduced in areas where the dhps581 mutation (a key marker of high level SP resistance) is found; this mutation was previously reported to be common in the Tanga Region of northern Tanzania, but there are limited data from other areas...
June 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28574336/early-infant-diagnosis-of-hiv-in-myanmar-call-for-innovative-interventions-to-improve-uptake-and-reduce-turnaround-time
#18
Soe Thiha, Hemant Deepak Shewade, Sairu Philip, Thet Ko Aung, Nang Thu Thu Kyaw, Myo Minn Oo, Khine Wut Yee Kyaw, May Wint War, Htun Nyunt Oo
BACKGROUND: In collaboration with the national AIDS program, early infant diagnosis (EID) is implemented by Integrated HIV Care (IHC) program through its anti-retroviral therapy (ART) centers across 10 cities in five states and regions of Myanmar. Blood samples from the ART centers are sent using public transport to a centralized PCR facility. OBJECTIVES: Among HIV-exposed babies <9 months at enrolment into IHC program (2013-15), to describe the EID cascade (enrolment, sample collection for PCR, result receipt by mother, HIV diagnosis and ART initiation) and factors associated with delayed (>8 weeks of age) or no blood sample collection for EID...
2017: Global Health Action
https://www.readbyqxmd.com/read/28571575/active-case-finding-for-tuberculosis-by-mobile-teams-in-myanmar-yield-and-treatment-outcomes
#19
Ohnmar Myint, Saw Saw, Petros Isaakidis, Mohammed Khogali, Anthony Reid, Nguyen Binh Hoa, Thi Thi Kyaw, Ko Ko Zaw, Tin Mi Mi Khaing, Si Thu Aung
BACKGROUND: Since 2005, the Myanmar National Tuberculosis Programme (NTP) has been implementing active case finding (ACF) activities involving mobile teams in hard-to-reach areas. This study revealed the contribution of mobile team activities to total tuberculosis (TB) case detection, characteristics of TB patients detected by mobile teams and their treatment outcomes. METHODS: This was a descriptive study using routine programme data between October 2014 and December 2014...
June 2, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28548141/glass-capillary-based-microfluidic-elisa-for-rapid-diagnostics
#20
Xiaotian Tan, Maung Kyaw Khaing Oo, Yuan Gong, Yaoxin Li, Hongbo Zhu, Xudong Fan
Enzyme-linked immunosorbent assay (ELISA) is widely used in medical diagnostics and fundamental biological research due to its high specificity and reproducibility. However, the traditional 96-well-plate based ELISA still suffers from several notable drawbacks, such as long assay time (4-6 hours), burdensome procedures and large sample/reagent volumes (∼100 μl), which significantly limit traditional ELISA's applications in rapid clinical diagnosis and quasi-real-time prognosis of some fast-developing diseases...
May 26, 2017: Analyst
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