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https://www.readbyqxmd.com/read/28212409/pathogenic-waterborne-free-living-amoebae-an-update-from-selected-southeast-asian-countries
#1
Mohamad Azlan Abdul Majid, Tooba Mahboob, Brandon G J Mong, Narong Jaturas, Reena Leeba Richard, Tan Tian-Chye, Anusorn Phimphila, Panomphanh Mahaphonh, Kyaw Nyein Aye, Wai Lynn Aung, Joon Chuah, Alan D Ziegler, Atipat Yasiri, Nongyao Sawangjaroen, Yvonne A L Lim, Veeranoot Nissapatorn
Data on the distribution of free-living amoebae is still lacking especially in Southeast Asian region. The aquatic environment revealed a high occurrence of free-living amoebae (FLA) due to its suitable condition and availability of food source, which subsequently causes infection to humans. A total of 94 water samples consisted of both treated and untreated from Laos (31), Myanmar (42), and Singapore (21) were investigated for the presence of pathogenic FLA. Each water sample was filtered and cultured onto non-nutrient agar seeded with live suspension of Escherichia coli and incubated at room temperature...
2017: PloS One
https://www.readbyqxmd.com/read/28204571/in-vitro-combination-therapy-with-isavuconazole-against-candida-spp
#2
Aspasia Katragkou, Matthew McCarthy, Joseph Meletiadis, Kaiser Hussain, Patriss W Moradi, Gittel E Strauss, Kyaw L Myint, Myo H Zaw, Laura L Kovanda, Ruta Petraitiene, Emmanuel Roilides, Thomas J Walsh, Vidmantas Petraitis
No abstract text is available yet for this article.
February 16, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28196536/community-engagement-and-the-social-context-of-targeted-malaria-treatment-a-qualitative-study-in-kayin-karen-state-myanmar
#3
Kate Sahan, Christopher Pell, Frank Smithuis, Aung Kyaw Phyo, Sai Maung Maung, Chanida Indrasuta, Arjen M Dondorp, Nicholas J White, Nicholas P J Day, Lorenz von Seidlein, Phaik Yeong Cheah
BACKGROUND: The spread of artemisinin-resistance in Plasmodium falciparum is a threat to current global malaria control initiatives. Targeted malaria treatment (TMT), which combines mass anti-malarial administration with conventional malaria prevention and control measures, has been proposed as a strategy to tackle this problem. The effectiveness of TMT depends on high levels of population coverage and is influenced by accompanying community engagement activities and the local social context...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28185133/geographic-resource-allocation-based-on-cost-effectiveness-an-application-to-malaria-policy
#4
Tom L Drake, Yoel Lubell, Shwe Sin Kyaw, Angela Devine, Myat Phone Kyaw, Nicholas P J Day, Frank M Smithuis, Lisa J White
Healthcare services are often provided to a country as a whole, though in many cases the available resources can be more effectively targeted to specific geographically defined populations. In the case of malaria, risk is highly geographically heterogeneous, and many interventions, such as insecticide-treated bed nets and malaria community health workers, can be targeted to populations in a way that maximises impact for the resources available. This paper describes a framework for geographically targeted budget allocation based on the principles of cost-effectiveness analysis and applied to priority setting in malaria control and elimination...
February 10, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28182786/high-rate-of-virological-failure-and-low-rate-of-switching-to-second-line-treatment-among-adolescents-and-adults-living-with-hiv-on-first-line-art-in-myanmar-2005-2015
#5
Nang Thu Thu Kyaw, Anthony D Harries, Ajay M V Kumar, Myo Minn Oo, Khine Wut Yee Kyaw, Than Win, Thet Ko Aung, Aung Chan Min, Htun Nyunt Oo
BACKGROUND: The number of people living with HIV on antiretroviral treatment (ART) in Myanmar has been increasing rapidly in recent years. This study aimed to estimate rates of virological failure on first-line ART and switching to second-line ART due to treatment failure at the Integrated HIV Care program (IHC). METHODS: Routinely collected data of all adolescent and adult patients living with HIV who were initiated on first-line ART at IHC between 2005 and 2015 were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28181626/important-factors-in-predicting-mortality-outcome-from-stroke-findings-from-the-anglia-stroke-clinical-network-evaluation-study
#6
Phyo Kyaw Myint, Max O Bachmann, Yoon Kong Loke, Stanley D Musgrave, Gill M Price, Rachel Hale, Anthony Kneale Metcalf, David A Turner, Diana J Day, Elizabeth A Warburton, John F Potter
No abstract text is available yet for this article.
January 28, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28166680/opposing-roles-of-b-lymphocyte-subsets-in-atherosclerosis
#7
Tin Kyaw, Peter Tipping, Alex Bobik, Ban-Hock Toh
Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable atherosclerotic lesions initiates thrombotic occlusion of vital arteries precipitating heart attacks and strokes that remain major killers globally despite therapeutic use of statins to lower blood cholesterol levels...
February 2017: Autoimmunity
https://www.readbyqxmd.com/read/28164751/pernicious-anemia-fundamental-and-practical-aspects-in-diagnosis
#8
Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo
Pernicious anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of pernicious anemia is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis...
February 3, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28161569/the-spread-of-artemisinin-resistant-plasmodium-falciparum-in-the-greater-mekong-subregion-a-molecular-epidemiology-observational-study
#9
Mallika Imwong, Kanokon Suwannasin, Chanon Kunasol, Kreepol Sutawong, Mayfong Mayxay, Huy Rekol, Frank M Smithuis, Tin Maung Hlaing, Kyaw M Tun, Rob W van der Pluijm, Rupam Tripura, Olivo Miotto, Didier Menard, Mehul Dhorda, Nicholas P J Day, Nicholas J White, Arjen M Dondorp
BACKGROUND: Evidence suggests that the PfKelch13 mutations that confer artemisinin resistance in falciparum malaria have multiple independent origins across the Greater Mekong subregion, which has motivated a regional malaria elimination agenda. We aimed to use molecular genotyping to assess antimalarial drug resistance selection and spread in the Greater Mekong subregion. METHODS: In this observational study, we tested Plasmodium falciparum isolates from Myanmar, northeastern Thailand, southern Laos, and western Cambodia for PfKelch13 mutations and for Pfplasmepsin2 gene amplification (indicating piperaquine resistance)...
February 1, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28156670/frequency-and-factors-associated-patients-decisional-control-preferences-dcp-in-patients-with-advanced-cancer-acp
#10
Luis Fernando Rodrigues, Omar M Shamieh, Columbe Tricou, Marilène Filbet, Kyaw Naing, Akhileswaran Ramaswamy, Mary Joycylyn S Bautista, Pedro Emilio Perez-Cruz, Mary Ann Muckaden, Sofia Bunge, Sarah Fakrooden, Vikash Sewram, Antonio Noguera Tejedor, Minjeong Park, Diane D Liu, Suresh K Reddy, Eduardo Bruera
: 37 Background: To determine the frequency and socio-demographic and clinical factors associated passive DCP among ACP across the world. METHODS: We conducted a survey of ACP referred to palliative care across 11 countries across the five continents across the world. Information was collected on socio-demographic variables, and using validated measures including Karnofsky Performance Scale, Decision Control Preference Scale, and Satisfaction with the Decisions and Care questionnaire...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156515/perception-of-curability-in-an-international-cohort-of-advanced-cancer-patients-receiving-palliative-care
#11
Omar M Shamieh, Luis Fernando Rodrigues, Columbe Tricou, Marilène Filbet, Kyaw Naing, Akhileswaran Ramaswamy, Mary Joycylyn S Bautista, Pedro Emilio Perez-Cruz, Sarah Fakrooden, Mary Ann Muckaden, Sofia Bunge, Vikash Sewram, Antonio Noguera Tejedor, David Hui, Minjeong Park, Diane D Liu, Eduardo Bruera
: 5 Background: There is limited data on the illness understanding and perception of cure among advanced cancer patients (ACP) receiving palliative care around the world. The aim of the study was to determine the frequency and factors associated with perception of curability in countries in North and South Americas , Europe, Asia and Africa. METHODS: Secondary analysis of a study to determine the decisional control preferences in different countries. ACP receiving palliative care were surveyed to assess the patients' Understanding of Illness using a Understanding Of Illness questionnaire...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28145642/clinical-features-of-influenza-and-acute-respiratory-illness-in-older-adults-at-least-50-years-of-age-in-an-outpatient-setting-in-the-republic-of-korea-a-prospective-observational-cohort-study
#12
Woo Joo Kim, Jin Soo Lee, Chang Kyu Lee, Hee Jin Cheong, Mijeong Kim, Javier Sawchik Monegal, Rute Carneiro, Moe H Kyaw, François Haguinet, Riju Ray, Gonçalo Matias
Two prospective, multi-centre, observational studies (GlaxoSmithKline [GSK] identifier No. 110938 and 112519) were performed over 2 influenza seasons (2007-2008 and 2008-2009) in the Republic of Korea (ROK) with the aim to evaluate the burden of laboratory-confirmed influenza (LCI) in patients ≥ 50 years of age seeking medical attention for acute respiratory illness (ARI). The median participant age was 58 years in the 2007-2008 season and 60 years in the 2008-2009 season. LCI was observed in 101/346 (29...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28119047/variable-number-of-tandem-repeats-of-9-plasmodium-vivax-genes-among-southeast-asian-isolates
#13
Bo Wang, Myat Htut Nyunt, Seung-Gyu Yun, Feng Lu, Yang Cheng, Jin-Hee Han, Kwon-Soo Ha, Won Sun Park, Seok-Ho Hong, Chae-Seung Lim, Jun Cao, Jetsumon Sattabongkot, Myat Phone Kyaw, Liwang Cui, Eun-Taek Han
The variable number of tandem repeats (VNTRs) provides valuable information about both the functional and evolutionary aspects of genetic diversity. Comparative analysis of 3 Plasmodium falciparum genomes has shown that more than 9% of its open reading frames (ORFs) harbor VNTRs. Although microsatellites and VNTR genes of P. vivax were reported, the VNTR polymorphism of genes has not been examined widely. In this study, 230 P. vivax genes were analyzed for VNTRs by SERV, and 33 kinds of TR deletions or insertions from 29 P...
January 21, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28117032/assessing-sensitivity-and-specificity-of-surveillance-case-definitions-for-zika-virus-disease
#14
Angela Chow, Hanley Ho, Mar-Kyaw Win, Yee-Sin Leo
We evaluated performance of 5 case definitions for Zika virus disease surveillance in a human cohort during an outbreak in Singapore, August 26-September 5, 2016. Because laboratory tests are largely inaccessible, use of case definitions that include rash as a required clinical feature are useful in identifying this disease.
April 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28112215/zebularine-upregulates-expression-of-cyp-genes-through-inhibition-of-dnmt1-and-pkr-in-hepg2-cells
#15
Kazuaki Nakamura, Kazuko Aizawa, Kyaw Htet Aung, Junji Yamauchi, Akito Tanoue
Drug-induced hepatotoxicity is one of the major reasons cited for drug withdrawal. Therefore, it is of extreme importance to detect human hepatotoxic candidates as early as possible during the drug development process. In this study, we aimed to enhance hepatocyte functions such as CYP gene expression in HepG2 cells, one of the most extensively used cell lines in evaluating hepatotoxicity of chemicals and drugs. We found that zebularine, a potent inhibitor of DNA methylation, remarkably upregulates the expression of CYP genes in HepG2 cells...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#16
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28063141/influence-of-atomic-hydrogen-band-bending-and-defects-in-the-top-few-nanometers-of-hydrothermally-prepared-zinc-oxide-nanorods
#17
Mubarak J Al-Saadi, Salim H Al-Harthi, Htet H Kyaw, Myo T Z Myint, Tanujjal Bora, Karthik Laxman, Ashraf Al-Hinai, Joydeep Dutta
We report on the surface, sub-surface (top few nanometers) and bulk properties of hydrothermally grown zinc oxide (ZnO) nanorods (NRs) prior to and after hydrogen treatment. Upon treating with atomic hydrogen (H*), upward and downward band bending is observed depending on the availability of molecular H2O within the structure of the NRs. In the absence of H2O, the H* treatment demonstrated a cleaning effect of the nanorods, leading to a 0.51 eV upward band bending. In addition, enhancement in the intensity of room temperature photoluminescence (PL) signals due to the creation of new surface defects could be observed...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28051776/foxp3-cd4-regulatory-t-cell-subtypes-and-atherosclerosis
#18
EDITORIAL
Tin Kyaw, Ban-Hock Toh, Alex Bobik
No abstract text is available yet for this article.
November 11, 2016: Circulation Research
https://www.readbyqxmd.com/read/28031679/elevated-factor-viii-levels-associated-with-acute-graft-occlusion-and-arterial-and-venous-thrombosis-after-off-pump-cabg
#19
Crystal A Kyaw, Pey-Jen Yu, Frank Manetta
Factor VIII is a common acute phase reactant and elevated levels confer an increased risk of thrombosis. Such thrombotic events have been documented in the literature, though to a limited extent. We present the case of a 54-year-old man presenting with a non-Q-wave myocardial infarction who was found to have triple vessel disease and subsequently underwent a 4-vessel coronary artery bypass grafting (CABG). Postoperatively, he was found to have multiple occluded vessels, deep vein thromboses, and a cerebrovascular accident (CVA)...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28028434/infection-prevention-and-control-of-clostridium-difficile-a-global-review-of-guidelines-strategies-and-recommendations
#20
Evelyn Balsells, Teodora Filipescu, Moe H Kyaw, Camilla Wiuff, Harry Campbell, Harish Nair
BACKGROUND: Clostridium difficile is the leading cause of health care-associated infections. Given the high incidence of C. difficile infection (CDI) and the lack of primary prevention through immunization, health care professionals should be aware of the most current guidance, as well as strengths and limitations of the evidence base underpinning this guidance. METHODS: We identified publicly available national or organizational guidelines related to CDI infection and prevention control (IPC) published between 2000 and 2015 and for any health care setting through an internet search using the Google search engine...
December 2016: Journal of Global Health
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