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https://www.readbyqxmd.com/read/29455973/microbicidal-gentamicin-alginate-hydrogels
#1
Stalin Kondaveeti, Pedro Vinicius de Assis Bueno, Ana Maria Carmona-Ribeiro, Fernanda Esposito, Nilton Lincopan, Maria Rita Sierakowski, Denise Freitas Siqueira Petri
Sodium alginate (Alg) reacted with antibiotic gentamicin sulfate (GS) in an aqueous-phase condition mediated by carbodiimide chemistry, in the molar ratios Alg: GS of (1:0.5), (1:1) and (1:2). The Alg-GS conjugated derivatives were characterized by elemental analysis for nitrogen content, Fourier transform infrared spectroscopy in the attenuated total reflection mode (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), thermogravimetric analyses (TGA) and water sorption measurements...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29448627/polysaccharide-functionalized-single-walled-carbon-nanotubes-as-nanocarriers-for-delivery-of-curcumin-in-lung-cancer-cells
#2
Neha Singh, Abhay Sachdev, P Gopinath
Nanoscale drug delivery systems have emerged as promising alternatives to overcome the problems associated with by conventional chemotherapy for cancer treatment such as poor drug stability and bio-distribution. Herein, we report a single walled carbon nanotubes (SWCNTs) based drug delivery system functionalized with polysaccharides such as alginate (ALG) and chitosan (CHI), which can be loaded with an anticancer drug curcumin (CUR). Modification of SWCNTs renders high drug loading efficiency and sustained drug release, imperative for drug activity...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29432744/a-microtubule-associated-protein-map1b-binds-to-and-regulates-localization-of-a-calcium-binding-protein-alg-2
#3
Terunao Takahara, Yumika Arai, Yuta Kono, Hideki Shibata, Masatoshi Maki
MAP1B (microtubule-associated protein 1B) binds to microtubules and regulates microtubule dynamics. Previously, we showed calcium-dependent interaction between MAP1B and a calcium-binding protein ALG-2 (apoptosis-linked gene 2), which is involved in regulation of the protein secretion pathway. Although ALG-2 generally binds to proteins through two consensus binding motifs such as ABM-1 and ABM-2, the absence of these motifs in MAP1B suggests a unique binding mode between MAP1B and ALG-2. Here, we identified the region of mouse MAP1B responsible for binding to ALG-2, and found point mutations that abrogated binding of MAP1B to ALG-2...
February 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29421060/alginate-polymethacrylate-hybrid-hydrogels-for-potential-osteochondral-tissue-regeneration
#4
P Stagnaro, I Schizzi, R Utzeri, E Marsano, M Castellano
Porous scaffolds based on alginate-polymethacrylate hybrid hydrogels intended for bone and cartilage regeneration were prepared through controlled calcium ions diffusion from an agar mould. The double interconnected network of such materials combines into a single porous structure maintained by both noncovalent crosslinks (calcium ions for alginate) and covalent crosslinks (polymethacrylate crosslinked by the addition of mixtures of mono and bifunctional monomers). The alginate component ensures the appropriate micro-environment to mimic the extra-cellular matrix, whereas the polymethacrylate improves the mechanical performances of the hybrid hydrogels, helping to overcome the mechanical limitations of the alginate component...
April 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29407146/microneedles-fabricated-from-alginate-and-maltose-for-transdermal-delivery-of-insulin-on-diabetic-rats
#5
Yang Zhang, Guohua Jiang, Weijiang Yu, Depeng Liu, Bin Xu
To reduce the inconvenient and painful of subcutaneous needle injection, the calcium ion cross-linked alginate/maltose (Ca2+/Alg-Mal) composite microneedles have been fabricated by a template method. The as-prepared microneedles exhibited strong mechanical properties with the highest failure force around 0.41N/needle. The biological activity and stability of loaded insulin in microneedles were investigated. Due to the good mechanical properties and excellent biocompatibility, the as-prepared microneedles have been applied for transdermal delivery of insulin on diabetic Sprague-Dawley (SD) rat models in vivo...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29393630/visible-light-induced-hydrogelation-of-an-alginate-derivative-and-application-to-stereolithographic-bioprinting-using-a-visible-light-projector-and-acid-red
#6
Shinji Sakai, Hidenori Kamei, Toko Mori, Tomoki Hotta, Hiromi Ohi, Masaki Nakahata, Masahito Taya
Visible light-induced hydrogelation is attractive for various biomedical applications. In this study, hydrogels of alginate with phenolic hydroxyl groups (Alg-Ph) were obtained by irradiating a solution containing the polymer, ruthenium II trisbipyridyl chloride ([Ru(bpy)3]2+) and sodium persulfate (SPS), with visible light. The hydrogelation kinetics and the mechanical properties of the resultant hydrogels were tunable by controlling the intensity of the light and the concentrations of [Ru(bpy)3]2+ and SPS...
February 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29392929/homologous-sodium-alginate-chitosan-based-scaffolds-but-contrasting-effect-on-stem-cell-shape-and-osteogenesis
#7
Lili Zhang, Haowei Fang, Kunxi Zhang, Jingbo Yin
Stem cell shape appears to be involved in the regulation of osteogenesis, which has been confirmed in two dimensional surfaces and three dimensional hydrogels. The present study was to evaluate the effect of matrix-controlled cellular shape on osteogenesis in three dimensional porous scaffolds based on the sodium alginate (ALG) and chitosan (CS). Three ALG/CS scaffolds, especially including a stiff one, were fabricated from different precursor matrices. Soft scaffold A was fabricated from ALG/CS polyelectrolyte, and further cross-linked by Ca2+ and glutaraldehyde to achieve soft scaffold B with alterative hydrophilicity...
February 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29378324/adhesive-free-standing-multilayer-films-containing-sulfated-levan-for-biomedical-applications
#8
Tiago D Gomes, Sofia G Caridade, Maria P Sousa, Sara Azevedo, Muhammed Y Kandur, Ebru T Öner, Natália M Alves, João F Mano
This work is the first reporting the use of layer-by-layer to produce adhesive free-standing (FS) films fully produced using natural-based macromolecules: chitosan (CHI), alginate (ALG) and sulfated levan (L-S). The deposition conditions of the natural polymers were studied through zeta potential measurements and quartz crystal microbalance with dissipation monitoring analysis. The properties of the FS films were evaluated and compared with the control ones composed of only CHI and ALG in order to assess the influence of levan polysaccharide introduced in the multilayers...
January 26, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29357442/characterization-of-urinary-exosomal-release-of-aquaporin-1-and-2-after-renal-ischemia-reperfusion-in-rats
#9
Siree Asvapromtada, Hiroko Sonoda, Minami Kinouchi, Sayaka Oshikawa, Saki Takahashi, Yuya Hoshino, Thitaporn Sinlapadeelerdkul, Naoko Yokota-Ikeda, Toshiyuki Matsuzaki, Masahiro Ikeda
Acute kidney injury (AKI) is an important risk factor for the development of chronic kidney disease (CKD) and an alteration in renal water handling has been observed during the transition of AKI to CKD. Urinary exosomal release of aquaporin-1 (AQP1) and AQP2, important proteins for renal water handling, has recently been reported to predict their levels of renal expression. We therefore examined the patterns of urinary exosomal release of AQP1 and AQP2, and the exosomal marker proteins tumor susceptibility 101 protein (TSG101) and ALG-2 interacting protein X (Alix), in the acute and chronic phases following induction of AKI by renal bilateral ischemia/reperfusion (I/R) in rats...
December 13, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29352409/recent-perspectives-on-the-molecular-basis-of-biofilm-formation-by-pseudomonas-aeruginosa-and-approaches-for-treatment-and-biofilm-dispersal
#10
REVIEW
Sinosh Skariyachan, Vaishnavi Sneha Sridhar, Swathi Packirisamy, Supreetha Toplar Kumargowda, Sneha Basavaraj Challapilli
Pseudomonas aeruginosa, a Gram-negative, rod-shaped bacterium causes widespread diseases in humans. This bacterium is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteriaemia especially in immunocompromised patients. The current review focuses on the recent perspectives on biofilms formation by these bacteria. Biofilms are communities of microorganisms in which cells stick to each other and often adhere to a surface. These adherent cells are usually embedded within a self-produced matrix of extracellular polymeric substance (EPS)...
January 19, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29348172/-the-a-arrestin-arrdc3-suppresses-breast-carcinoma-invasion-by-regulating-g-protein-coupled-receptor-lysosomal-sorting-and-signaling
#11
Aleena K S Arakaki, Wen-An Pan, Huilan Lin, JoAnn Trejo
Aberrant G protein-coupled receptor (GPCR) expression and activation has been linked to tumor initiation, progression, invasion and metastasis. However, compared with other cancer drivers, the exploitation of GPCRs as potential therapeutic targets has been largely ignored, despite the fact that GPCRs are highly druggable. Therefore, to advance the potential status of GPCRs as therapeutic targets, it is important to understand how GPCRs function together with other cancer drivers during tumor progression. We now report that the alpha-arrestin domain-containing protein-3 (ARRDC3) acts as a tumor suppressor in part by controlling signaling and trafficking of the GPCR, protease-activated receptor-1 (PAR1)...
January 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29335632/long-term-outcome-analysis-of-reduced-intensity-allogeneic-stem-cell-transplantation-in-patients-with-mantle-cell-lymphoma-a-retrospective-study-from-the-ebmt-lymphoma-working-party
#12
Stephen P Robinson, Ariane Boumendil, Herve Finel, Karl S Peggs, Patrice Chevallier, Jorge Sierra, Jürgen Finke, Xavier Poiré, Natacha Maillard, Noël Milpied, Ibrahim Yakoub-Agha, Mickey Koh, Nicolaus Kröger, Arnon Nagler, Yener Koc, Sascha Dietrich, Silvia Montoto, Peter Dreger
Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29334797/association-of-functional-mmp-2-gene-variant-with-intracranial-aneurysms-case-control-genetic-association-study-and-meta-analysis
#13
Varinder S Alg, Xiayi Ke, Joan Grieve, Stephen Bonner, Daniel C Walsh, Diederik Bulters, Neil Kitchen, Henry Houlden, David J Werring
INTRODUCTION: Abnormalities in Matrix Metalloproteinase (MMP) genes, which are important in extracellular matrix (ECM) maintenance and therefore arterial wall integrity are a plausible underlying mechanism of intracranial aneurysm (IA) formation, growth and subsequent rupture. We investigated whether the rs243865 C > T SNP (single nucleotide polymorphism) within the MMP-2 gene (which influences gene transcription) is associated with IA compared to matched controls. MATERIALS AND METHODS: We conducted a case-control genetic association study, adjusted for known IA risk factors (smoking and hypertension), in a UK Caucasian population of 1409 patients with intracranial aneurysms (IA), and 1290 matched controls, to determine the association of the rs243865 C > T functional MMP-2 gene SNP with IA (overall, and classified as ruptured and unruptured)...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29320372/a-dentin-derived-hydrogel-bioink-for-3d-bioprinting-of-cell-laden-scaffolds-for-regenerative-dentistry
#14
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane M França, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz E Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
January 10, 2018: Biofabrication
https://www.readbyqxmd.com/read/29310686/comparison-of-two-different-coagulation-algorithms-on-the-use-of-allogenic-blood-products-and-coagulation-factors-in-severely-injured-trauma-patients-a-retrospective-multicentre-observational-study
#15
Alexander Kaserer, Mattias Casutt, Kai Sprengel, Burkhardt Seifert, Donat R Spahn, Philipp Stein
BACKGROUND: At the University Hospital Zurich (USZ) and the Cantonal Hospital of Lucerne (LUKS) an individualized goal-directed coagulation and transfusion algorithm was introduced and implemented before 2012 (Coagulation algorithm of the USZ: USZ-Alg; of the LUKS: LUKS-Alg). Main differences between both algorithms are: 1) A target haematocrit-range of 0.21-0.24 (USZ-Alg) vs. a lower haematocrit limit only (LUKS-Alg). 2) Blind coagulation-package in selected cases (LUKS-Alg only). 3) Factor XIII substitution is considered earlier according to the USZ-Alg...
January 8, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29304429/mechanical-behaviour-of-alginate-gelatin-hydrogels-for-3d-bioprinting
#16
Michael Di Giuseppe, Nicholas Law, Braeden Webb, Ryley A Macrae, Lawrence J Liew, Timothy B Sercombe, Rodney J Dilley, Barry J Doyle
Hydrogels comprised of alginate and gelatin have demonstrated potential as biomaterials in three dimensional (3D) bioprinting applications. However, as with all hydrogel-based biomaterials used in extrusion-based bioprinting, many parameters influence their performance and there is limited data characterising the behaviour of alginate-gelatin (Alg-Gel) hydrogels. Here we investigated nine Alg-Gel blends by varying the individual constituent concentrations. We tested samples for printability and print accuracy, compressive behaviour and change over time, and viability of encapsulated mesenchymal stem cells in bioprinted constructs...
December 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29297676/diffusion-control-in-the-in-situ-synthesis-of-iconic-metal-organic-frameworks-within-an-ionic-polymer-matrix
#17
Jungho Lim, Eun Ji Lee, Jae Sun Choi, Nak Cheon Jeong
Ionic polymers that possess ion-exchangeable sites have been shown to be a greatly useful platform to fabricate mixed matrices (MMs) where metal-organic framework (MOFs) can be in situ synthesized, although the in situ synthesis of MOF has been rarely studied. In this study, alginate, an anionic green polymer that possesses metal ion-exchangeable sites, is employed as a platform of MMs for the in situ synthesis of iconic MOFs, HKUST-1 and MOF-74(Zn). We demonstrate for the first time that the sequential order of supplying MOF ingredients (metal ion and deprotonated ligand) into the alginate matrix leads to substantially different results due to a difference in the diffusion of the MOF components...
January 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29284259/cold-and-hot-gelling-of-alginate-graft-pnipam-a-schizophrenic-behavior-induced-by-potassium-salts
#18
Hui Guo, Mickaël De Magalhaes Goncalves, Guylaine Ducouret, Dominique Hourdet
Recently, alginates (ALG) characterized by high mannuronic content (M blocks) have been shown to undergo a reversible sol/gel transition during cooling in the presence of potassium salts. Cold gelling takes place at low temperatures, just below 0 °C for a KCl concentration of 0.3 mol/kg, but the aggregation process can be easily shifted to higher temperatures by increasing the salt concentration. In the present paper, we take advantage of this peculiar behavior to design a copolymer with schizophrenic gelling properties...
December 29, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29277987/bioinspired-manganese-chelated-alginate-poly-dopamine-nanomaterials-for-efficient-in-vivo-t1%C3%A2-weighted-magnetic-resonance-imaging-mri
#19
Kefyalew Dagnew Addisu, Balkew Zewge Hailemeskel, Shewaye Lakew Mekuria, Abegaz Tizazu Andrgie, Yu-Chun Lin, Hsieh-Chih Tsai
Manganese-based nanomaterials are an emerging new class of magnetic resonance imaging (MRI) contrast agents (CAs) that provide impressive contrast abilities. MRI CAs that can respond to pathophysiological parameters like pH or redox potential are also highly demanded for MRI guided tumor diagnosis. Until now, synthesizing nanomaterials with good biocompatibility, physio-chemical stability, and good contrast effects remain challenging. This study investigated two new systems of calcium/manganese cations complexed with either alginate-polydopamine or alginate-dopamine nanogels (AlgPDA(Ca/Mn) NG or AlgDA (Ca/Mn) NG)...
December 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29250831/injectable-simvastatin-gel-for-minimally-invasive-periosteal-distraction-in-vitro-and-in-vivo-studies-in-rat
#20
Jia Hao, Joshua Chou, Shinji Kuroda, Makoto Otsuka, Shohei Kasugai, Niklaus P Lang
OBJECTIVES: To evaluate whether the subperiosteal injection of simvastatin (SIM) with a novel in situ gel-forming system, SrHA/Alg (strontium hydroxyapatite/alginate), can stimulate vertical bone augmentation in a rat calvarial model. MATERIAL AND METHODS: The SrHA/Alg solution was synthesized and combined with different doses of SIM (0.01, 0.02, 0.1, and 0.2 mg) to form the following groups: (1) SrHA/Alg only, (2) SrHA/Alg/0.01, (3) SrHA/Alg/0.02, (4) SrHA/Alg/0...
December 18, 2017: Clinical Oral Implants Research
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