keyword
MENU ▼
Read by QxMD icon Read
search

Alge

keyword
https://www.readbyqxmd.com/read/29238191/induction-of-apoptosis-in-hela-cancer-cells-by-an-ultrasonic-mediated-synthesis-of-curcumin-loaded-chitosan-alginate-stpp-nanoparticles
#1
Fatemeh Ahmadi, Maryam Ghasemi-Kasman, Shahram Ghasemi, Maryam Gholamitabar Tabari, Roghayeh Pourbagher, Sohrab Kazemi, Ali Alinejad-Mir
Natural herbal compounds have been widely introduced as an alternative therapeutic approach in cancer therapy. Despite potent anticancer activity of curcumin, its clinical application has been limited because of low water solubility and resulting poor bioavailability. In this study, we designed a novel ultrasonic-assisted method for the synthesis of curcumin-loaded chitosan-alginate-sodium tripolyphosphate nanoparticles (CS-ALG-STPP NPs). Furthermore, antitumor effect of curcumin-loaded NPs was evaluated in vitro...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29205950/biodegradable-nanoparticles-enhanced-adhesiveness-of-mussel-like-hydrogels-at-tissue-interface
#2
Nikhil Pandey, Amirhossein Hakamivala, Cancan Xu, Prashant Hariharan, Boris Radionov, Zhong Huang, Jun Liao, Liping Tang, Philippe Zimmern, Kytai T Nguyen, Yi Hong
Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin-glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-based, biodegradable tissue adhesive is developed by blending poly(lactic-co-glycolic acid) (PLGA) or N-hydroxysuccinimide modified PLGA nanoparticles (PLGA-NHS) with mussel-inspired alginate-dopamine polymer (Alg-Dopa)...
December 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29205068/evaluation-of-the-role-of-incentive-structure-on-student-participation-and-performance-in-active-learning-strategies-a-comparison-of-case-based-and-team-based-learning
#3
Gonzalo A Carrasco, Kathryn C Behling, Osvaldo J Lopez
BACKGROUND: Student participation is important for the success of active learning strategies, but participation is often linked to the level of preparation. At our institution, we use two types of active learning activities, a modified case-based learning exercise called active learning groups (ALG) and team-based learning (TBL). These strategies have different assessment and incentive structures for participation. Non-cognitive skills are assessed in ALG using a subjective five-point Likert scale...
December 5, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29195799/fabrication-of-carboxylated-cellulose-nanocrystal-sodium-alginate-hydrogel-beads-for-adsorption-of-pb-ii-from-aqueous-solution
#4
Zhao-Hong Hu, Ahmed Mohamed Omer, Xiao-Kun Ouyang, Di Yu
Carboxylated cellulose nanocrystal-sodium alginate (CCN-Alg) hydrogel beads were easily prepared through a cross-linking method. The structure and properties of the composite beads were characterized by TEM, FTIR, SEM, XPS, thermogravimetric analysis (TGA), and zeta potential measurement. A high ratio of 76% of the Pb(II) ion was adsorbed within the first 2h, and the adsorption equilibrium was nearly reached after 3h. The experimental isotherm could be fitted by the Langmuir model, yielding an extreme adsorption capacity of 338...
November 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29181888/preconditioned-augmented-lagrangian-formulation-for-nearly-incompressible-cardiac-mechanics
#5
J O Campos, R W Dos Santos, J Sundnes, B M Rocha
Computational modeling of the heart is a subject of substantial medical and scientific interest, which may contribute to increase the understanding of several phenomena associated with cardiac physiological and pathological states. Modeling the mechanics of the heart have led to considerable insights, but it still represents a complex and a demanding computational problem, especially in a strongly coupled electromechanical setting. Passive cardiac tissue is commonly modeled as hyperelastic, and is characterized by quasi-incompressible, orthotropic and non-linear material behavior...
November 27, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29171778/effect-of-matrix-composition-sphere-size-and-hormone-concentration-on-diffusion-coefficient-of-insulin-for-controlled-gastrointestinal-delivery-for-diabetes-treatment
#6
Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz, Alvaro Luiz Mathias
Oral insulin administration is limited due to its degradation by proteases. The hormone was encapsulated in spheres made of either pure calcium alginate (ALG) or its association with whey protein isolate (WPI-ALG) in order to minimize loss in the stomach region while allowing liberation in the maximum absorption area, located in the intestine. Diffusion coefficients for both matrix compositions were determined in vitro for gastric pH (5.88 and 10.26 10(-12) m(2) s(-1)) and intestinal pH (21.11 and 79.29 10(-12) m(2) s(-1))...
November 24, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29171434/nischarin-sirna-delivered-by-polyethylenimine-alginate-nanoparticles-accelerates-motor-function-recovery-after-spinal-cord-injury
#7
Yue-Min Ding, Yu-Ying Li, Chu Wang, Hao Huang, Chen-Chen Zheng, Shao-Han Huang, Yang Xuan, Xiao-Yi Sun, Xiong Zhang
A previous study by our group found that inhibition of nischarin promotes neurite outgrowth and neuronal regeneration in Neuro-2a cells and primary cortical neurons. In recent years, more and more studies have shown that nanomaterials have good prospects in treatment of spinal cord injury. We proposed that small interfering RNA targeting nischarin (Nis-siRNA) delivered by polyethyleneimine-alginate (PEI-ALG) nanoparticles promoted motor function recovery in rats with spinal cord injury. Direct microinjection of 5 μL PEI-ALG/Nis-siRNA into the spinal cord lesion area of spinal cord injury rats was performed...
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29157906/novel-decellularized-liver-matrix-alginate-hybrid-gel-beads-for-the-3d-culture-of-hepatocellular-carcinoma-cells
#8
Dongsheng Sun, Yang Liu, Huihui Wang, Fei Deng, Ying Zhang, Shan Zhao, Xiaojun Ma, Huijian Wu, Guangwei Sun
Developing reliable three-dimensional (3D) cell culture systems that can mimic native tumor microenvironments is necessary for investigating the mechanism of hepatocellular carcinoma (HCC) metastasis and screen therapeutic drugs. In the present study, we developed decellularized liver matrix-alginate (DLM-ALG) hybrid gel beads. DLM powder was prepared by optimized decellularization methods and liquid nitrogen grinding. DLM-ALG beads were generated by dropping alginate solution containing DLM powder into a gelling bath...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29148982/a-dentin-derived-hydrogel-bioink-for-3d-printing-of-cell-laden-scaffolds-for-regenerative-dentistry
#9
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane Miranda Franca, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
November 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/29138082/synthesis-of-chitosan-alginate-microspheres-with-high-antimicrobial-and-antibiofilm-activity-against-multi-drug-resistant-microbial-pathogens
#10
Rajagopalan Thaya, Baskaralingam Vaseeharan, Jeyachandran Sivakamavalli, Arokiadhas Iswarya, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Mohammed N Al-Anbr, Jamal M Khaled, Giovanni Benelli
The successful treatment of multi-drug resistant microbial pathogens represents a major challenge for public health management. Here, chitosan-alginate (CS/ALG) microspheres with narrow size distribution were fabricated by ionically cross linking method using Ca(2+) ions as agents for polymer solidification. The physicochemical properties of CS/ALG microspheres, such as surface morphology and size, were studied by SEM. The functional group interactions were confirmed by Fourier transform infrared (FTIR) spectroscopy...
November 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29135939/bioactive-molecules-release-and-cellular-responses-of-alginate-tricalcium-phosphate-particles-hybrid-gel
#11
Dipankar Das, Sumi Bang, Shengmin Zhang, Insup Noh
In this article, a hybrid gel has been developed using sodium alginate (Alg) and α-tricalcium phosphate (α-TCP) particles through ionic crosslinking process for the application in bone tissue engineering. The effects of pH and composition of the gel on osteoblast cells (MC3T3) response and bioactive molecules release have been evaluated. At first, a slurry of Alg and α-TCP has been prepared using an ultrasonicator for the homogeneous distribution of α-TCP particles in the Alg network and to achieve adequate interfacial interaction between them...
November 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29135325/facile-development-of-nanocomplex-in-nanoparticles-for-enhanced-loading-and-selective-delivery-of-doxorubicin-to-brain
#12
Amr Hefnawy, Islam A Khalil, Ibrahim M El-Sherbiny
AIM: Facile development of polysaccharides-based carrier system for efficient delivery of doxorubicin (DOX) to the brain. METHODS: DOX was nanocomplexed with alginate (Alg) followed by incorporation into chitosan (Cs) nanomatrices. The resulting carriers were optimized to have a net positive charge improving their delivery across the blood-brain barrier. The optimum DOX-loaded nanosystem was targeted to brain tissue via loading into various nasal dosage forms. RESULTS: The pH-dependent ionization of both DOX and Alg was found to have a significant effect on DOX entrapment efficiency which was improved from 4% at slightly acidic media to 85% using different pHs...
November 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29129734/ciprofloxacin-loaded-sodium-alginate-poly-lactic-co-glycolic-acid-electrospun-fibrous-mats-for-wound-healing
#13
Xiaoli Liu, Line Hagner Nielsen, Sylvia Natalie Klodzinska, Hanne Mørck Nielsen, Haiyan Qu, Lars Porskjær Christensen, Jukka Rantanen, Mingshi Yang
Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles...
November 9, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29122714/diethanolamine-modified-pectin-based-core-shell-composites-as-dual-working-gastroretentive-drug-cargo
#14
Hriday Bera, Sanoj Kumar
The current study aimed at developing diethonolamine-modified high-methoxyl pectin (DMP)-alginate (ALG) based core-shell composites for controlled intragastric delivery of metformin HCl (MFM) by combined approach of floating and bioadhesion. DMP with degree of amidation of 48.72% was initially accomplished and characterized by FTIR, DSC and XRD analyses. MFM-loaded core matrices were then fabricated by ionotropic gelation technique employing zinc acetate as cross-linker. The core matrices were further coated by fenugreek gum (FG)-ALG gel membrane via diffusion-controlled interfacial complexation method...
November 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29117550/microrna-regulation-of-nachr-expression-and-nicotine-dependent-behavior-in-c-%C3%A2-elegans
#15
Manish Rauthan, Jianke Gong, Jinzhi Liu, Zhaoyu Li, Seth A Wescott, Jianfeng Liu, X Z Shawn Xu
Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not well understood. Here, we identify a key role for microRNA in regulating nicotine-dependent behavior by modulating nAChR expression in C. elegans. We show that the nAChR gene acr-19 and alg-1, a key Argonaute-family member in the microRNA machinery, are specifically required for nicotine withdrawal response following chronic nicotine treatment...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29114017/a-microrna-feedback-loop-regulates-global-microrna-abundance-during-aging
#16
Sachi Inukai, Zachary Pincus, Alexandre de Lencastre, Frank J Slack
Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcription and processing during C. elegans aging. We found that miRNA biogenesis genes are highly networked with transcription factors and aging-associated miRNAs. In particular, miR-71, known to influence lifespan and itself upregulated during aging, represses alg-1/Argonaute expression post-transcriptionally during aging...
November 7, 2017: RNA
https://www.readbyqxmd.com/read/29103499/multivalent-ion-based-in-situ-gelling-polysaccharide-hydrogel-as-an-injectable-bone-graft
#17
Sun Woo Jung, June-Ho Byun, Se Heang Oh, Tae Ho Kim, Ji-Sung Park, Gyu-Jin Rho, Jin Ho Lee
We prepared in situ gelling alginate (ALG)/hyaluronic acid (HA) hydrogels with a controllable gelation rate using CaSO4 as a crosslinking agent and Na2HPO4 as a crosslinking retardation agent. The ALG/HA hydrogels provided sustained release of bone morphogenetic protein-2 (BMP-2) immobilized in the hydrogels over 5 weeks. The BMP-2-immobilized ALG/HA hydrogels with different ALG/HA ratios were investigated for their in vitro osteogenic differentiation behavior of human bone marrow stem cells (hBMSCs) and in vivo bone regeneration behavior using an animal model (mandibular defect model of miniature pigs)...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29098871/design-of-antihistaminic-transdermal-films-based-on-alginate-chitosan-polyelectrolyte-complexes-characterization-and-permeation-studies
#18
Sonia Lefnaoui, Nadji Moulai-Mostefa, Madiha M Yahoum, Sarah N Gasmi
The purpose of this study was to develop suitable matrix type transdermal drug delivery systems of Ketotifen fumarate (KF) as antiasthmatic drugs. Chitosan-alginate polyelectrolyte complex (PEC) films were used as drug release regulators for KF. Antihistaminic films with variable PEC compositions were prepared using different ratios of chitosan (CTS) to sodium alginate (ALG). Propylene glycol (PG) was used as plasticizer; Tween 80 (T80) and Span 20 (S20) were used as permeability enhancers. Nine formulations were obtained by film casting method and characterized in terms of weight uniformity, thickness, folding endurance, moisture lost, and moisture absorption...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29097216/antimicrobial-antioxidant-and-anticancer-activities-of-zinc-nanoparticles-prepared-by-natural-polysaccharides-and-gamma-radiation
#19
Ahmed I El-Batal, Farag M Mosalam, M M Ghorab, Amro Hanora, Ahmed M Elbarbary
Aqueous dispersed zinc nanoparticles (ZnNPs) were synthesized using natural polysaccherides (chitosan (CS), citrus pectin (CP) and alginate (Alg)) using aqueous fermented fenugreek powder (FFP) by Pleurotus ostreatus as reducing and stabilizing agent or using gamma irradiation. The synthesized ZnNPs are characterized by ultra violect spectroscopy (UV), Transmission electronmicroscopy (TEM), Dynamic light scattering (DLS), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). XRD analysis of the ZnNPS confirmed the formation of metallic nanoparticles...
October 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29091392/thiol-benzo-triazolo-quinazolinone-covalently-modifies-alg44-to-inhibit-c-di-gmp-binding-and-reduces-alginate-production-by-pseudomonas-aeruginosa
#20
Eric Zhou, Anna B Seminara, Soo-Kyoung Kim, Cherisse L Hall, Yan Wang, Vincent T Lee
Pseudomonas aeruginosa is an opportunistic pathogen that affects a large proportion of cystic fibrosis (CF) patients. CF patients have dehydrated mucus within the airways that leads to the inability of the mucociliary escalator to expel inhaled microbes. Once inhaled, P. aeruginosa can persist in the lungs of the CF patients for the remainder of their lives. During this chronic infection, a phenomenon called mucoid conversion can occur in which P. aeruginosa can mutate and inactivate their mucA gene. As a consequence, transcription of the alg operon is highly expressed leading to the copious secretion of the alginate exopolysaccharide, which is associated with decreased lung function and increased CF patient morbidity and mortality...
November 1, 2017: ACS Chemical Biology
keyword
keyword
92182
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"