keyword
https://read.qxmd.com/read/38283064/development-of-the-short-form-yin-deficiency-scale-using-three-item-reduction-approaches
#21
JOURNAL ARTICLE
Young-Jae Park, Ji-Myung Ok
BACKGROUND: Yin deficiency (YD) is a pathological condition characterized by emaciation, afternoon fever, dry mouth, and night sweats. The incidence of YD is 23.3%. A 27-item Yin Deficiency Scale (YDS) was developed to estimate the clinical severity of YD. This study aimed to develop three short-form YDS versions to reduce the burden of response time, using three item-reduction approaches: Rasch, equidiscriminatory item-total correlation (EITC), and factor-based analyses. METHODS: Two datasets were analyzed from previous studies (169 outpatients from May to June 2009 and 237 healthy college students from January to April 2016)...
2024: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/38251523/1-year-results-of-treatment-with-rituximab-in-polymyalgia-rheumatica-an-extension-study-of-a-randomised-double-blind-placebo-controlled-trial
#22
RANDOMIZED CONTROLLED TRIAL
Thomas E Bolhuis, Diane E Marsman, Alfons A den Broeder, Nathan den Broeder, Aatke van der Maas
BACKGROUND: Rituximab was effective for patients with polymyalgia rheumatica in the 21-week BRIDGE-PMR randomised controlled trial. Here, we aimed to assess rates of glucocorticoid-free remission up to 1 year after infusion in an extension of this trial. METHODS: BRIDGE-PMR was a randomised controlled proof-of-concept trial that enrolled participants with polymyalgia rheumatica according to 2012 European League Against Rheumatism-American College of Rheumatology classification criteria at the Sint Maartenskliniek, Nijmegen, Netherlands...
April 2023: Lancet Rheumatology
https://read.qxmd.com/read/38244536/-effects-of-pulmonary-rehabilitation-on-dysfunctional-respiratory-patterns-in-patients-with-uncontrolled-asthma
#23
JOURNAL ARTICLE
Franziska Ebert, Nikolaus Ballenberger, Markus C Hayden, Dirk Möller, Matthias Limbach, Michael Schuler, Dennis Nowak, Konrad Schultz
PURPOSE: Dysfunctional breathing patterns (DAM) are deviations from physiologic breathing patterns. DAM seem to be associated with lower asthma control. To date, it is unclear what effect inpatient rehabilitation can have on this problem. The aim of this work is to investigate the effect of pulmonary rehabilitation (PR) on DAM. METHODS: The data are based on a randomized controlled trial with a waiting control group. The intervention group (IG) received PR 4 weeks after application approval and the control group (KG) after 5 months...
January 20, 2024: Die Rehabilitation
https://read.qxmd.com/read/38226065/children-with-severe-asthma-have-substantial-structural-airway-changes-on-computed-tomography
#24
JOURNAL ARTICLE
Wytse B van den Bosch, Qianting Lv, Eleni-Rosalina Andrinopoulou, Mariëlle W H Pijnenburg, Pierluigi Ciet, Hettie M Janssens, Harm A W M Tiddens
BACKGROUND: In adults with severe asthma (SA) bronchial wall thickening, bronchiectasis and low attenuation regions (LAR) have been described on chest computed tomography (CT) scans. The extent to which these structural abnormalities are present in children with SA is largely unknown. Our aim was to study the presence and extent of airway abnormalities on chest CT of children with SA. METHODS: 161 inspiratory and expiratory CT scans, either spirometer-controlled or technician-controlled, obtained in 131 children with SA (mean±SD age 11...
January 2024: ERJ Open Research
https://read.qxmd.com/read/38212823/effect-of-buteyko-breathing-technique-on-clinical-and-functional-parameters-in-adult-patients-with-asthma-a-randomized-controlled-study
#25
RANDOMIZED CONTROLLED TRIAL
Katrin Vagedes, Silja Kuderer, Rainer Ehmann, Matthias Kohl, Johannes Wildhaber, Rudolf A Jörres, Jan Vagedes
BACKGROUND: The established therapy of asthma might be supported by additional non-pharmaceutical measures, such as the Buteyko breathing technique (BBT); however, the available data are mixed. To clarify the effects of BBT in patients with asthma, we investigated whether it led to clinical improvements with correlation to functional parameters. METHODS: Using a randomized, controlled design, we studied two groups (n = 30 each) of patients with asthma under either BBT or usual therapy (UT) w/o BBT over a period of 3 months...
January 11, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38206060/cochlear-implantation-in-sporadic-intralabyrinthine-schwannomas-with-single-sided-deafness-implications-for-binaural-hearing
#26
JOURNAL ARTICLE
Niels West, Rikke Skovhøj Sørensen, Abigail Anne Kressner, Michael Bille, Jeremy Marozeau, Per Cayé-Thomasen
BACKGROUND AND OBJECTIVE: Intralabyrinthine schwannomas (ILSs) may have detrimental effects on ipsilateral hearing, commonly leading to single-sided deafness (SSD). Cochlear implantation in patients with ILSs is an option to partly restore ipsilateral hearing; however, the available literature fails to account for the binaural hearing benefits of a cochlear implant (CI) for ILSs. METHODS: We prospectively evaluated SSD patients with sporadic ILS undergoing cochlear implantation with simultaneous tumor resection (n = 10) or with tumor observation (n = 1)...
February 1, 2024: Otology & Neurotology
https://read.qxmd.com/read/38193066/effect-of-emicizumab-neutralizing-antibodies-on-activated-partial-thromboplastin-time-based-clotting-time-test-results-in-patients-treated-with-emicizumab
#27
JOURNAL ARTICLE
Cristina Novembrino, Massimo Boscolo-Anzoletti, Eleonora Galbiati, Sho Shinohara, Flora Peyvandi
BACKGROUND: Emicizumab is a bispecific humanized monoclonal antibody that shortens the activated partial thromboplastin time (aPTT), making aPTT-based tests unreliable. OBJECTIVES: To evaluate the efficacy of a mixture of 2 anti-idiotype monoclonal antibodies (anti-emi) in neutralizing emicizumab in samples from persons with hemophilia A treated with emicizumab. METHODS: Fifty samples from persons with hemophilia A treated with emicizumab were analyzed for aPTT and factor VIII procoagulant activity; FVIII inhibitor titer was measured using Nijmegen-Bethesda assay in 50 plasma samples of additional patients (positive for FVIII inhibitor) treated with emicizumab...
November 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38192153/suppression-of-nbs1-upregulates-cyclinb-to-induce-olaparib-sensitivity-in-ovarian-cancer
#28
JOURNAL ARTICLE
Ailing Zhong, Chien-Shan Cheng, Ren Quan Lu, Lin Guo
Background: Deficiencies in DNA damage repair responses promote chemotherapy sensitivity of tumor cells. The Nibrin homolog encoding gene Nijmegen Breakage Syndrome 1 (NBS1) is a crucial component of the MRE11-RAD50-NBN complex (MRN complex) and is involved in the response to DNA double-strand breaks (DSBs) repair that has emerged as an attractive strategy to overcome tumor drug resistance, but the functional relationship between NBS1 regulated DNA damage repair and cell cycle checkpoints has not been fully elucidated...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38186198/neurological-involvement-in-patients-with-primary-immunodeficiency
#29
JOURNAL ARTICLE
Hulya Kose, Zuhal Karali, Muhittin Bodur, Sukru Cekic, Sara Sebnem Kilic
INTRODUCTION: Primary immunodeficiency diseases (PID) are defined by recurrent infections, allergies, autoimmunity, and malignancies. Neurologic symptoms are one of the major components of some immunodeficiency syndromes, such as Ataxia-Telangiectasia (AT), Nijmegen breakage syndrome (NBS), and Purine Nucleoside Phosphorylase (PNP) deficiency, which are considered as the primary involvement. Various pathological mechanisms, DNA repair disorders, metabolic abnormalities, and autoimmune phenomena have also been linked with neurological conditions...
2024: Allergologia et Immunopathologia
https://read.qxmd.com/read/38166740/continuity-of-primary-care-for-type-2-diabetes-and-hypertension-and-its-association-with-health-outcomes-and-disease-control-insights-from-central-vietnam
#30
JOURNAL ARTICLE
Quynh-Anh Le Ho Thi, Peter Pype, Johan Wens, Huy Nguyen Vu Quoc, Anselme Derese, Wim Peersman, Nhon Bui, Huyen Nguyen Thi Thanh, Tam Nguyen Minh
BACKGROUND: Vietnam is undergoing a rapid epidemiological transition with a considerable burden of non-communicable diseases (NCDs), especially hypertension and diabetes (T2DM). Continuity of care (COC) is widely acknowledged as a benchmark for an efficient health system. This study aimed to determine the COC level for hypertension and T2DM within and across care levels and to investigate its associations with health outcomes and disease control. METHODS: A cross-sectional study was conducted on 602 people with T2DM and/or hypertension managed in primary care settings...
January 2, 2024: BMC Public Health
https://read.qxmd.com/read/38149835/correction-to-positive-diepoxybutane-test-in-a-patient-with-nijmegen-breakage-syndrome-by-marta-s-gallego-c-z-barreiro-s-danielian-s-d-rosenweig-pediatr-blood-cancer-2007-jul-49-1-110-https-doi-org-10-1002-pbc-20941-pmid-16862537
#31
https://read.qxmd.com/read/38138877/is-age-a-limiting-factor-for-audiological-results-in-active-middle-ear-implants
#32
JOURNAL ARTICLE
J Manuel Morales-Puebla, Luis Lassaletta, Isabel Sánchez-Cuadrado, Miryam Calvino, Javier Gavilán
Active middle ear implants (AMEI) are implantable options for patients with sensorineural, conductive, or mixed hearing loss who are not good candidates for hearing aids. The aim of this study was to compare audiological, surgical, quality of life, and sound quality outcomes in adults <60 and ≥60 years receiving an AMEI. Twenty adult patients who underwent AMEI implantation were divided into two groups, <60 and ≥60 y. Preoperative tests included pure-tone average and speech discrimination score (SDS) at 65 dB for disyllabic words in quiet...
November 26, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/38074514/influence-of-cooperation-work-on-management-continuity-of-ambulatory-cardiovascular-care-a-cross-sectional-exploratory-study-in-germany
#33
JOURNAL ARTICLE
Christine Arnold, Patrick Hennrich, Frank Peters-Klimm, Michel Wensing
INTRODUCTION: A wide range of factors influence coordination and continuity of care. The aim of this study was to explore how management continuity of cardiovascular-related ambulatory care is influenced by the following network characteristics: presence of a case coordinator, network reciprocity, network composition and team climate. METHODS: This cross-sectional observational study included three written surveys. The primary outcome management continuity of cardiovascular care was measured with the team/cross-boundary scale in the Nijmegen Continuity Questionnaire...
2023: International Journal of Integrated Care
https://read.qxmd.com/read/38036249/associations-of-breathing-pattern-disorder-and-nijmegen-score-with-clinical-outcomes-in-difficult-to-treat-asthma
#34
JOURNAL ARTICLE
Anna Freeman, Steevo Abraham, Latha Kadalayil, Judit Varkonyi-Sepp CPsychol, Ben Ainsworth, J J Hudson-Colby, Clair Barber, Paddy Dennison, Adnan Azim, Heena Mistry, Peter Howarth, Ratko Djukanovic, Hongmei Zhang, S Hasan Arshad, Hans Michael Haitchi, Ramesh J Kurukulaaratchy
BACKGROUND: Breathing pattern disorder (BPD) reflects altered biomechanical patterns of breathing that drive breathing difficulty and commonly accompanies difficult-to-treat asthma. Diagnosis of BPD has no gold standard, but Nijmegen Questionnaire (NQ) >23 is commonly used. OBJECTIVES: We sought to advance clinical characterisation of BPD and better understand clinical utility of NQ in difficult asthma, in patients from the Wessex AsThma CoHort of difficult asthma (WATCH) study...
November 28, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/37962371/long-term-effects-of-surgically-corrected-menstrual-outflow-obstruction-a-case-control-study
#35
JOURNAL ARTICLE
Lisanne Martens, Marian A Spath, Monique A van Beek, Wim N P Willemsen, Kirsten B Kluivers
OBJECTIVE: To enhance evidence-based knowledge on long-term sequalae in patients with surgically corrected obstructing Müllerian anomalies. METHODS: This long-term case-control study included patients with menstrual outflow obstruction due to congenital anomalies of the uterus or vagina, who were at least 18 years old, and for whom 2 years had elapsed since the first surgery at the start of this study. The control group consisted of women without current gynecological problems...
November 14, 2023: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/37920167/metastasis-of-ovarian-cancer-to-nasal-skin-and-skin-on-the-trunk-a-rare-case-report
#36
Chen Chen, Ouyang Yingyao, Xiang Yan, He Qianru, Wang Hong, Chen Chen, Yang Lei
Cutaneous metastases of ovarian cancer are rare and often have poor prognosis. We report a case of a 62-year-old woman with recurrent low-grade serous ovarian cancer, who presented with lung, brain, and multiple skin (nasal and anterior chest wall) metastases approximately six months after the initial diagnosis. In this case, Nijmegen breakage syndrome carrier status caused by RAD50 heterozygous mutation and previous bevacizumab therapy could be the predisposing factor for cutaneous metastases. The patient was treated with local radiotherapy (nasal skin and brain, 30Gy/6f/1...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37917166/influence-of-depressive-disorders-stress-and-personality-traits-on-quality-of-life-after-cochlear-implantation
#37
JOURNAL ARTICLE
Susen Lailach, Paula Stephan, Johanna Martin, Thomas Zahnert, Marcus Neudert
PURPOSE: This study aimed to determine whether preoperative depressiveness, stress, and personality influence quality of life (QOL) after cochlear implant (CI) surgery. METHODS: In this prospective study, 79 patients undergoing CI surgery were evaluated preoperatively and 12 months postoperatively. Disease-specific QOL was assessed with the Nijmegen Cochlear Implant Questionnaire (NCIQ) and general QOL with the WHOQOL-BREF. Depressiveness and stress were assessed with the Patient Health Questionnaire (PHQ-D)...
November 2, 2023: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/37887644/qol-cis-qalys-and-individualized-rehabilitation-the-clinical-and-practical-benefits-of-regularly-assessing-the-quality-of-life-of-adult-cochlear-implant-recipients
#38
JOURNAL ARTICLE
Luis Lassaletta, Miryam Calvino, Isabel Sanchez-Cuadrado, Piotr Henryk Skarzynski, Katarzyna B Cywka, Natalia Czajka, Justyna Kutyba, Dayse Tavora-Vieira, Paul Van de Heyning, Griet Mertens, Hinrich Staecker, Bryan Humphrey, Mario Zernotti, Maximo Zernotti, Astrid Magele, Marlene Ploder, Julia Speranza Zabeu
This study aimed to report quality of life (QoL) scores in unilateral cochlear implant (CI) users and to generate guidance for clinicians on using QoL measures to individualize CI counselling and rehabilitation and to increase access to CIs as a mode of rehabilitation. Participants (n = 101) were unilateral CI users with single-sided deafness (SSD; n = 17), asymmetrical hearing loss (AHL; n = 26), or bilateral hearing loss (Uni; n = 58). Generic QoL was assessed via the Health Utilities Index (HUI-3), and disease-specific QoL was assessed via the Speech, Spatial, and Qualities of Hearing scale (SSQ12) and Nijmegen CI Questionnaire (NCIQ) at preimplantation and at 6 and 12 months of CI use...
October 10, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/37853142/analysis-of-variation-characteristics-transport-paths-and-influencing-factors-of-atmospheric-no-2-pollution-in-western-europe
#39
JOURNAL ARTICLE
Jiaming Zhang, Tianzhen Ju, Bingnan Li, Chunxue Li, Jinyang Wang, Xuhui Xia, Xiaowen Niu
Climate change and air pollution are one of the global environmental problems. It is significant to grasp the air pollution situation of Western Europe in recent 10 years for its or the global pollution control. Based on the OMI tropospheric nitrogen dioxide (NO2 ) column density data, the spatial and temporal distribution characteristics, variation trend, transmission path, and influencing factors of NO2 in 15 countries in Western Europe from 2011 to 2022 are discussed in this paper. Meanwhile, the annual average spatial and temporal distribution in 2023 is predicted by the random forest (RF) model...
October 18, 2023: Environmental Monitoring and Assessment
https://read.qxmd.com/read/37844518/the-nijmegen-ultra-sensitive-bethesda-assay-detects-very-low-titer-factor-viii-inhibitors-in-patients-with-congenital-and-acquired-hemophilia-a
#40
JOURNAL ARTICLE
Lars L F G Valke, Marieke J A Verhagen, Bart T P M Mulders, Robert Polenewen, Nicole M A Blijlevens, Joop H Jansen, Hassan Mansouritorghabeh, Einas Elsheikh, Birgit M Reipert, Peter L Turecek, James S O'Donnell, Sanna R Rijpma, Saskia E M Schols, Waander L van Heerde, Danielle Meijer
BACKGROUND: An inhibitor can develop in congenital hemophilia A (HA) patients against exogenous infused factor (F)VIII, whereas in acquired HA (AHA) inhibitors initially develop against endogenous FVIII. Inhibitors can be detected with the Nijmegen Bethesda Assay (NBA), which has an international cut-off level of 0.60 Nijmegen Bethesda Units/mL (NBU/mL). Thereby, very low-titer inhibitors may remain undetected. AIM: To describe the design and validation of the Nijmegen ultra-sensitive Bethesda Assay (NusBA) for the detection of very low-titer inhibitors...
October 11, 2023: Thrombosis Research
keyword
keyword
9218
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.