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https://www.readbyqxmd.com/read/28441693/sex-differences-in-fat-distribution-influence-the-association-between-bmi-and-arterial-stiffness
#1
Inge C L van den Munckhof, Suzanne Holewijn, Jacqueline de Graaf, Joost H W Rutten
CONTEXT AND OBJECTIVE: The increase in arterial stiffness in patients with the metabolic syndrome is strongly related to the amount of visceral adipose tissue. In clinical practice, anthropometric measurements such as BMI and waist circumference are commonly used to assess general and abdominal adiposity. Waist circumference is a composite measure of subcutaneous and visceral abdominal adipose tissue. As the distribution of intra-abdominal fat differs between men and women, we investigated the sex-specific associations between different anthropometric measures for general and abdominal obesity with arterial stiffness...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28439719/radiological-imaging-of-teratological-fetuses-what-can-we-learn
#2
REVIEW
Lucas L Boer, A N Schepens-Franke, J J A van Asten, D G H Bosboom, K Kamphuis-van Ulzen, T L Kozicz, D J Ruiter, R-J Oostra, W M Klein
OBJECTIVES: To determine the advantages of radiological imaging of a collection of full-term teratological fetuses in order to increase their scientific and educational value. BACKGROUND : Anatomical museums around the world exhibit full-term teratological fetuses. Unfortunately, these museums are regularly considered as "morbid cabinets". Detailed dysmorphological information concerning the exhibited specimens is often lacking. Moreover, fetuses with severe and complex congenital anomalies are frequently diagnosed incompletely, incorrectly or not at all...
April 24, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28430587/parkin-regulates-translesion-dna-synthesis-in-response-to-uv-radiation
#3
Xuefei Zhu, Xiaolu Ma, Yingfeng Tu, Min Huang, Hongmei Liu, Fengli Wang, Juanjuan Gong, Jiuqiang Wang, Xiaoling Li, Qian Chen, Hongyan Shen, Shu Zhu, Yun Wang, Yang Liu, Caixia Guo, Tie-Shan Tang
Deficiency of Parkin is a major cause of early-onset Parkinson's disease (PD). Notably, PD patients also exhibit a significantly higher risk in melanoma and other skin tumors, while the mechanism remains largely unknown. In this study, we show that depletion of Parkin causes compromised cell viability and genome stability after ultraviolet (UV) radiation. We demonstrate that Parkin promotes efficient Rad18-dependent proliferating cell nuclear antigen (PCNA) monoubiquitination by facilitating the formation of Replication protein A (RPA)-coated ssDNA upon UV radiation...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407251/investigating-hyperventilation-syndrome-in-patients-suffering-from-empty-nose-syndrome
#4
David Mangin, Emilie Bequignon, Francoise Zerah-Lancner, Daniel Isabey, Bruno Louis, Serge Adnot, Jean-François Papon, André Coste, Laurent Boyer, Marie Devars du Mayne
OBJECTIVES/HYPOTHESIS: Patients with empty nose syndrome (ENS) following turbinate surgery often complain about breathing difficulties. We set out to determine if dyspnea in patients with ENS was associated with hyperventilation syndrome (HVS). We hypothesized that lower airway symptoms in ENS could be explained by HVS. STUDY DESIGN: Observational prospective study. METHODS: All consecutive patients referred to our center for ENS over 1 year were invited to participate...
April 13, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28392333/outcome-of-hematopoietic-cell-transplantation-for-dna-double-strand-breakage-repair-disorders
#5
James Slack, Michael H Albert, Dmitry Balashov, Bernd H Belohradsky, Alice Bertaina, Jack Bleesing, Claire Booth, Jochen Büchner, Rebecca H Buckley, Marie Ouachée-Chardin, Elena Deripapa, Katarzyna Drabko, Mary Eapen, Tobias Feuchtinger, Andrea Finocchi, H Bobby Gaspar, Sujal Ghosh, Alfred Gillio, Luis I Gonzalez-Granado, Eyal Grunebaum, Tayfun Güngör, Carsten Heilmann, Merja Helminen, Kohei Higuchi, Kohsuke Imai, Krzysztof Kalwak, Nubuo Kanazawa, Gülsün Karasu, Zeynep Y Kucuk, Alexandra Laberko, Andrzej Lange, Nizar Mahlaoui, Roland Meisel, D Moshous, Hideki Muramatsu, Suhag Parikh, Srdjan Pasic, Irene Schmid, Catharina Schuetz, Ansgar Schulz, Kirk R Schultz, Peter J Shaw, Mary A Slatter, Karl-Walter Sykora, Shinobu Tamura, Mervi Taskinen, Angela Wawer, Beata Wolska-Kus Nierz, Morton J Cowan, Alain Fischer, Andrew R Gennery
BACKGROUND: Rare DNA breakage-repair disorders predispose to infection and lympho-reticular malignancies. Hematopoietic cell transplantation (HCT) is curative but co-administered chemo- or radio-therapy is damaging due to systemic radio-sensitivity. We collected HCT outcome data for Nijmegen Breakage syndrome (NBS), DNA ligase IV deficiency (LIG4), Cernunnos-XLF deficiency and ataxia-telangiectasia. METHODS: Data from 38 centres worldwide, including indication, donor, conditioning regimen, graft-versus-host disease (GvHD) and outcome were analyzed...
April 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28369484/nbs1-is-regulated-by-two-kind-of-mechanisms-atm-dependent-complex-formation-with-mre11-and-rad50-and-cell-cycle-dependent-degradation-of-protein
#6
Hui Zhou, Kasumi Kawamura, Hiromi Yanagihara, Junya Kobayashi, Qiu-Mei Zhang-Akiyama
Nijmegen breakage syndrome (NBS), a condition similar to Ataxia-Telangiectasia (A-T), is a radiation-hypersensitive genetic disorder showing chromosomal instability, radio-resistant DNA synthesis, immunodeficiency, and predisposition to malignances. The product of the responsible gene, NBS1, forms a complex with MRE11 and RAD50 (MRN complex). The MRN complex is necessary for the DNA damage-induced activation of ATM. However, the regulation of MRN complex formation is still unclear. Here, we investigated the regulatory mechanisms of MRN complex formation...
March 22, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28331838/bibliometric-analysis-of-literature-on-antifungal-triazole-resistance-1980-2015
#7
Waleed M Sweileh, Ansam F Sawalha, Samah Al-Jabi, Sa'ed H Zyoud
BACKGROUND: Triazole antifungal agents play an important role in the treatment of a wide range of fungal infections. Little is known about antifungal triazole drug resistance when compared to antibiotic resistance. Therefore, this study was carried out to give a bibliometric overview of literature on triazole antifungal drug resistance. METHODS: Keywords related to triazole drug class and resistance were used in a search query in the Scopus search engine. The time span was set from 1980 to 2015...
March 2017: Germs
https://www.readbyqxmd.com/read/28293782/baha-implant-as-a-hearing-solution-for-single-sided-deafness-after-retrosigmoid-approach-for-the-vestibular-schwannoma-surgical-results
#8
Jan Boucek, Jan Vokral, Libor Cerny, Martin Chovanec, Jiří Skrivan, Eduard Zverina, Jan Betka, Michal Zabrodsky
Skull base tumors and, in particular, vestibular schwannoma (VS) are among the etiological reasons for single-sided deafness (SSD). Patients with SSD have problems in understanding speech in a noisy environment and cannot localize the direction of sounds. Baha is one of the most frequently used systems for SSD compensation. Out of 38 patients with SSD after retrosigmoid removal of VS who underwent testing with Baha softband, 16 were satisfied and were indicated for Baha implantation. Two surgical approaches have been used-the Nijmegen linear incision technique with subdermal thinning (Group I, implant BI300) and fast surgery technique without subdermal thinning (Group II, implant BIA400)...
March 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28284780/a-structured-approach-to-specialist-referred-difficult-asthma-patients-improves-control-of-comorbidities-and-enhances-asthma-outcomes
#9
Tunn Ren Tay, Joy Lee, Naghmeh Radhakrishna, Fiona Hore-Lacy, Robert Stirling, Ryan Hoy, Eli Dabscheck, Robyn O'Hehir, Mark Hew
BACKGROUND: Systematic evaluation is advocated for difficult asthma, but how best to deliver such care is unclear and outcome data are scarce. OBJECTIVE: We describe our institution's structured approach to difficult asthma management and report on the outcomes of such an approach. METHODS: Eighty-two consecutive patients with difficult asthma referred to our clinic from respiratory specialists were evaluated in 3 key areas: diagnostic confirmation, comorbidity detection, and inflammatory phenotyping...
March 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28271322/patient-benefit-from-cochlear-implantation-in-single-sided-deafness-a-1-year-follow-up
#10
Julia Louza, John-Martin Hempel, Eike Krause, Alexander Berghaus, Joachim Müller, Thomas Braun
The objective of the study was to evaluate the quality of life and benefit in patients with single-side deafness before and 1 year after cochlear implantation. In a prospective observational study design, ten adult patients with single-sided deafness undergoing cochlear implantation were included. All patients had on the implantation side no speech discrimination with normal hearing aids. The contralateral side was normal or marginal hearing loss. For determining the subject benefit from cochlear implantation, each patient answered standardized questionnaires directly before implantation and 1 year after...
March 7, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28258841/stimulation-of-lactate-receptor-hcar1-affects-cellular-dna-repair-capacity
#11
Waldemar Wagner, Katarzyna D Kania, Wojciech M Ciszewski
Numerous G-protein coupled receptors have been reported to enhance cancer cell survival and resistance to clinically used chemotherapeutics. Recently, hydroxycarboxylic acid receptor 1 (HCAR1) was shown to drive lactate-dependent enhancement of cell survival and metastasis in pancreatic and breast cancers. Furthermore, our previous study confirmed the involvement of HCAR1 in lactate-related enhancement of DNA repair in cervical cancer cells. In the present study, we examined the possible mechanisms of HCAR1-mediated enhancement of DNA repair capacity...
February 20, 2017: DNA Repair
https://www.readbyqxmd.com/read/28256356/intensive-speech-and-language-therapy-in-patients-with-chronic-aphasia-after-stroke-a-randomised-open-label-blinded-endpoint-controlled-trial-in-a-health-care-setting
#12
Caterina Breitenstein, Tanja Grewe, Agnes Flöel, Wolfram Ziegler, Luise Springer, Peter Martus, Walter Huber, Klaus Willmes, E Bernd Ringelstein, Karl Georg Haeusler, Stefanie Abel, Ralf Glindemann, Frank Domahs, Frank Regenbrecht, Klaus-Jürgen Schlenck, Marion Thomas, Hellmuth Obrig, Ernst de Langen, Roman Rocker, Franziska Wigbers, Christina Rühmkorf, Indra Hempen, Jonathan List, Annette Baumgaertner
BACKGROUND: Treatment guidelines for aphasia recommend intensive speech and language therapy for chronic (≥6 months) aphasia after stroke, but large-scale, class 1 randomised controlled trials on treatment effectiveness are scarce. We aimed to examine whether 3 weeks of intensive speech and language therapy under routine clinical conditions improved verbal communication in daily-life situations in people with chronic aphasia after stroke. METHODS: In this multicentre, parallel group, superiority, open-label, blinded-endpoint, randomised controlled trial, patients aged 70 years or younger with aphasia after stroke lasting for 6 months or more were recruited from 19 inpatient or outpatient rehabilitation centres in Germany...
March 1, 2017: Lancet
https://www.readbyqxmd.com/read/28250797/changes-in-peripheral-immune-cell-numbers-and-functions-in-octogenarian-walkers-an-acute-exercise-study
#13
Kornelis S M van der Geest, Qi Wang, Thijs M H Eijsvogels, Hans J P Koenen, Irma Joosten, Elisabeth Brouwer, Maria T E Hopman, Joannes F M Jacobs, Annemieke M H Boots
BACKGROUND: Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral immune parameters in octogenarians. Therefore, we investigated acute exercise-induced changes in phenotype and function of the immune system in octogenarians participating in the 2013 edition of the Nijmegen Four Days Marches. Blood sampling was performed at baseline and immediately after 4 days of the walking exercise (30 km/day)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28248612/health-related-quality-of-life-outcomes-following-adult-cochlear-implantation-a-prospective-cohort-study
#14
Douglas P Sladen, Ann Peterson, Matt Schmitt, Amy Olund, Katherine Teece, Brittany Dowling, Melissa DeJong, Alyce Breneman, Charles W Beatty, Matthew L Carlson, Brian A Neff, Becky Hughes-Borst, Colin L Driscoll
INTRODUCTION: The benefits of cochlear implantation extend beyond improved speech recognition and into overall health-related quality of life (HRQoL). Several measures of HRQoL, categorized as generic or disease specific, have been used in the cochlear implant literature. The clinical utility of generic HRQoL measures have been reported to be variable by previous investigators. The degree to which HRQoL correlates to speech perception is largely unknown. METHODS: A prospective single-subject design at a large tertiary care center...
May 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28183292/case-report-rapid-and-durable-response-to-pdgfr-targeted-therapy-in-a-child-with-refractory-multiple-infantile-myofibromatosis-and-a-heterozygous-germline-mutation-of-the-pdgfrb-gene
#15
Peter Mudry, Ondrej Slaby, Jakub Neradil, Jana Soukalova, Kristyna Melicharkova, Ondrej Rohleder, Marta Jezova, Anna Seehofnerova, Elleni Michu, Renata Veselska, Jaroslav Sterba
BACKGROUND: Infantile myofibromatosis belongs to a family of soft tissue tumors. The majority of these tumors have benign behavior but resistant and malignant courses are known, namely in tumors with visceral involvement. The standard of care is surgical resection. Observations suggest that low dose chemotherapy is beneficial. The treatment of resistant or relapsed patients with multifocal disease remains challenging. Patients that harbor an actionable mutation in the kinase domain are potential subjects for targeted tyrosine kinase inhibitor therapy...
February 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28181849/european-interprofessional-education-network-conference-nijmegen-the-netherlands-bridging-education-and-practice
#16
Nynke Scherpbier-de Haan, Albine Moser, Wietske Kuijer-Siebelink
No abstract text is available yet for this article.
March 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28152174/depression-case-finding-in-individuals-with-dementia-a-systematic-review-and-meta-analysis
#17
Zahra S Goodarzi, Bria S Mele, Derek J Roberts, Jayna Holroyd-Leduc
OBJECTIVES: To compare the diagnostic accuracy of depression case finding tools with a criterion standard in the outpatient setting among adults with dementia. DESIGN: Systematic review and meta-analysis. SETTING: Studies of older outpatients with dementia. PARTICIPANTS: Elderly outpatients (clinic and long-term care) with dementia (N = 3,035). MEASUREMENTS: Prevalence of major depression and diagnostic accuracy measures including sensitivity, specificity, and likelihood ratios...
February 2, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28145846/quality-of-life-after-sequential-bilateral-cochlear-implantation
#18
Edmund A Nahm, Penny Liberatos, Qiuhu Shi, Erica Lai, Ana H Kim
Objective Assess psychometric properties of the Comprehensive Cochlear Implant Questionnaire (CCIQ) as a tool for assessing changes in health-related quality of life (HRQoL) after receiving a second cochlear implant (CI2). Study Design Prospective study. Setting Academic cochlear implant center. Subjects and Methods The CCIQ is a 29-item questionnaire assessing the physical and psychosocial benefits of a CI2 based on a 5-point Likert scale. The CCIQ was administered with the Nijmegen Cochlear Implant Questionnaire and the Short Form-12 Patient Questionnaire (SF-12) to patients with a CI2...
February 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28145830/corrigendum
#19
(no author information available yet)
Hinderink JB, Krabbe PFM, van den Broek P. Development and application of a health-related quality-of-life instrument for adults with cochlear implants: The Nijmegen Cochlear Implant Questionnaire. Otolaryngol Head Neck Surg. 2000;123:756-765. (Original DOI: 10.1067/mhn.2000.108203 ).
February 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28137495/the-impact-of-dysfunctional-breathing-on-the-assessment-of-asthma-control
#20
Sandra Veidal, Maria Jeppegaard, Asger Sverrild, Vibeke Backer, Celeste Porsbjerg
BACKGROUND AND OBJECTIVE: Dysfunctional breathing (DB) is a respiratory disorder, which involves a pattern of breathing too deeply, too superficially and/or too rapidly. In asthma patients, DB may lead to an overestimation of the severity of asthma symptoms, and hence potentially to overtreatment. However, it is not known to which degree DB may affect estimates of asthma control, in a specialist clinical setting. METHODS: The MAPOut-study examined all patients referred consecutively over a 12-months period for specialist assessment of asthma at the Respiratory Outpatient Clinic at Bispebjerg Hospital in Copenhagen...
February 2017: Respiratory Medicine
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