keyword
MENU ▼
Read by QxMD icon Read
search

Nijmegen

keyword
https://www.readbyqxmd.com/read/28914395/repetitive-on-demand-drug-release-from-polymeric-matrices-containing-a-macroscopic-spherical-iron-core
#1
Stefan A Rovers, Maartje F Kemmere, Jos T F Keurentjes, Richard Hoogenboom
A system for multiple on-demand drug release has been prepared that can be activated with an alternating magnetic field as external trigger. The core/shell samples have been developed based on a macroscopic spherical iron core coated with a thermoresponsive polymer, poly(styrene-stat-butyl methacrylate), containing ibuprofen as a model drug. During exposure of the samples to the magnetic field (ON state), the release rate of ibuprofen is significantly increased, up to 35 times the release rate without the magnetic field (OFF state)...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28905471/novel-assessment-tool-to-detect-breathing-pattern-disorder-in-patients-with-refractory-asthma
#2
Sarah Todd, Emil S Walsted, Lizzie Grillo, Rebecca Livingston, Andrew Menzies-Gow, James H Hull
BACKGROUND AND OBJECTIVE: Breathing pattern disorder (BPD) can co-exist with and mimic asthma, acting to amplify symptoms and confound assessment of disease control, resulting in inappropriate treatment escalation. The aim of this research was to report the utility of a novel breathing pattern assessment tool (BPAT) to detect BPD in treatment-refractory asthma. METHODS: As a component of a multidisciplinary assessment, adult patients referred with treatment-refractory asthma underwent respiratory physiotherapy assessment to diagnose BPD...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28878046/nonlinear-temporal-dynamics-of-cerebral-small-vessel-disease-the-run-dmc-study
#3
Esther M C van Leijsen, Ingeborg W M van Uden, Mohsen Ghafoorian, Mayra I Bergkamp, Valerie Lohner, Eline C M Kooijmans, Helena M van der Holst, Anil M Tuladhar, David G Norris, Ewoud J van Dijk, Loes C A Rutten-Jacobs, Bram Platel, Catharina J M Klijn, Frank-Erik de Leeuw
OBJECTIVE: To investigate the temporal dynamics of cerebral small vessel disease (SVD) by 3 consecutive assessments over a period of 9 years, distinguishing progression from regression. METHODS: Changes in SVD markers of 276 participants of the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) cohort were assessed at 3 time points over 9 years. We assessed white matter hyperintensities (WMH) volume by semiautomatic segmentation and rated lacunes and microbleeds manually...
September 6, 2017: Neurology
https://www.readbyqxmd.com/read/28877863/the-paget-trial-a-multicenter-observational-cohort-intervention-study-for-the-clinical-efficacy-safety-and-immunological-response-of-topical-5-imiquimod-cream-for-vulvar-paget-disease
#4
Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu
BACKGROUND: Vulvar Paget disease is a rare skin disorder, which is most common in postmenopausal Caucasian women. They usually present with an erythematous plaque that may show fine or typical "cake icing" scaling or ulceration that may cause itching, pain, irritation, or a burning sensation. Although most cases are noninvasive, vulvar Paget disease may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The histological evidence of so-called "Paget cells" with abundant pale cytoplasm in the epithelium confirms the diagnosis...
September 6, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28870869/dysfunctional-breathing-is-more-frequent-in-chronic-obstructive-pulmonary-disease-than-in-asthma-and-in-health
#5
Natalie Law, Laurence E Ruane, Kathy Low, Kais Hamza, Philip G Bardin
Involuntary adaptations of breathing patterns to counter breathlessness may lead to dysfunctional breathing in obstructive lung diseases. However, no studies examining dysfunctional breathing in Chronic Obstructive Pulmonary Disease (COPD) have been reported. Patients with verified COPD (n=34), asthma (n=37) and a healthy control group (n=41) were recruited. All participants completed the Nijmegen questionnaire for dysfunctional breathing as well as measures of disease activity. Comparisons between groups employed analysis of variance with post-hoc Bonferroni analyses and Pearson correlation for associations...
September 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28863703/the-world-s-smallest-capacitive-dilatometer-for-high-resolution-thermal-expansion-and-magnetostriction-in-high-magnetic-fields
#6
R Küchler, A Wörl, P Gegenwart, M Berben, B Bryant, S Wiedmann
For the characterization of novel quantum phases of matter, it is often required to study materials under multi-extreme conditions, in particular down to very low temperatures and in very high magnetic fields. We developed the world's smallest high-resolution capacitive dilatometer suitable for temperatures down to 10 mK and usage in high magnetic fields up to 37.5 T. Despite the extreme miniaturization, the capacitive dilatometer can resolve length changes down to 0.01 Å. This is an unprecedented resolution in a capacitive dilatometer of this compact size...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28854719/techniques-used-for-iui-is-it-time-for-a-change
#7
L Lemmens, S Kos, C Beijer, D D M Braat, W L D M Nelen, A M M Wetzels
STUDY QUESTION: Are the guidelines for the technical aspects of IUI (WHO, 2010) still in accordance with the current literature? SUMMARY ANSWER: In general, the laboratory guidelines of the World Health Organization (WHO) are a suitable protocol, although the evidence is not always conclusive and some changes are advisable. WHAT IS KNOWN ALREADY: Lack of standardization of the technical procedures required for IUI might result in inter-laboratory variation in pregnancy rates...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28818006/the-role-of-the-bdnf-val66met-polymorphism-in-recovery-of-aphasia-after-stroke
#8
Riemke G A de Boer, Kerstin Spielmann, Majanka H Heijenbrok-Kal, Rick van der Vliet, Gerard M Ribbers, W Mieke E van de Sandt-Koenderman
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is assumed to play a role in mediating neuroplasticity after stroke. Carriers of the function-limiting Val66Met (rs6265) single nucleotide polymorphism (SNP) may have a downregulation in BDNF secretion, which may lead to a poorer prognosis after stroke compared to noncarriers in motor learning and motor function recovery. The present study investigates whether this polymorphism may also affect the recovery of poststroke aphasia (ie, language impairment)...
August 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28815880/immunogenicity-efficacy-and-safety-of-nuwiq-%C3%A2-human-cl-rhfviii-in-previously-untreated-patients-with-severe-haemophilia-a-interim-results-from-the-nuprotect-study
#9
R J Liesner, M Abashidze, O Aleinikova, C Altisent, M J Belletrutti, A Borel-Derlon, M Carcao, H Chambost, A K C Chan, L Dubey, J Ducore, N A Fouzia, M Gattens, Y Gruel, B Guillet, N Kavardakova, M El Khorassani, A Klukowska, T Lambert, S Lohade, M Sigaud, V Turea, J K M Wu, V Vdovin, A Pavlova, M Jansen, L Belyanskaya, O Walter, S Knaub, E J Neufeld
INTRODUCTION: Nuwiq(®) (Human-cl rhFVIII) is a fourth generation recombinant FVIII, produced in a human cell line, without chemical modification or protein fusion. No inhibitors developed in studies with Nuwiq(®) in 201 previously treated patients with haemophilia A (HA). The immunogenicity, efficacy and safety of Nuwiq(®) in previously untreated patients (PUPs) with severe HA are being assessed in the ongoing NuProtect study. METHODS: The study, conducted across 38 centres worldwide, is evaluating 110 true PUPs of all ages and ethnicities enrolled for study up to 100 exposure days (EDs) or 5 years maximum...
August 16, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28812947/a-concept-analysis-of-professional-commitment-in-nursing
#10
Loreto García-Moyano, Rogelio Altisent, Begoña Pellicer-García, Sandra Guerrero-Portillo, Oihana Arrazola-Alberdi, María Teresa Delgado-Marroquín
BACKGROUND: The concept of professional commitment is being widely studied at present. However, although it is considered an indicator for the most human part of nursing care, there is no clear definition for it, and different descriptors are being used indiscriminately to reference it. OBJECTIVE: The aim of this study is to clarify the concept of professional commitment in nursing through the Rodgers' evolutionary concept analysis process. DESIGN: Systematic search using English and Spanish descriptors and concept analysis...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28795528/limit-of-detection-and-threshold-for-positivity-of-the-centers-for-disease-control-and-prevention-assay-for-factor-viii-inhibitors
#11
Connie H Miller, Brian Boylan, Amy D Shapiro, Steven R Lentz, Brian M Wicklund
BACKGROUND: The Bethesda assay (BA) for measurement of factor VIII (FVIII) inhibitors called for quantitation of positive inhibitors using dilutions producing 25-75% residual activity (RA), corresponding to 0.4-2.0 Bethesda units, recommending use of "more sensitive methods" for samples with RA closer to 100%. The Nijmegen modification (NBA) changed the reagents used but not these calculations. Some specimens negative by NBA have been shown to have FVIII antibodies detectable by sensitive immunologic methods...
August 10, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28791007/prospective-study-of-a-cohort-of-russian-nijmegen-breakage-syndrome-patients-demonstrating-predictive-value-of-low-kappa-deleting-recombination-excision-circle-krec-numbers-and-beneficial-effect-of-hematopoietic-stem-cell-transplantation-hsct
#12
Elena Deripapa, Dmitry Balashov, Yulia Rodina, Alexandra Laberko, Natalya Myakova, Nataliia V Davydova, Maria A Gordukova, Dmitrii S Abramov, Galina V Pay, Larisa Shelikhova, Andrey P Prodeus, Mikhail A Maschan, Alexey A Maschan, Anna Shcherbina
BACKGROUND: Nijmegen breakage syndrome (NBS) is a combined primary immunodeficiency with DNA repair defect, microcephaly, and other phenotypical features. It predominantly occurs in Slavic populations that have a high frequency of carriers with the causative NBN gene c.657_661del5 mutation. Due to the rarity of the disease in the rest of the world, studies of NBS patients are few. Here, we report a prospective study of a cohort of Russian NBS patients. METHODS: 35 Russian NBS patients of ages 1-19 years, referred to our Center between years 2012 and 2016, were prospectively studied...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28790359/nijmegen-breakage-syndrome-fibroblasts-and-ipscs-cellular-models-for-uncovering-disease-associated-signaling-pathways-and-establishing-a-screening-platform-for-anti-oxidants
#13
Barbara Mlody, Wasco Wruck, Soraia Martins, Karl Sperling, James Adjaye
Nijmegen Breakage Syndrome (NBS) is associated with cancer predisposition, premature aging, immune deficiency, microcephaly and is caused by mutations in the gene coding for NIBRIN (NBN) which is involved in DNA damage repair. Dermal-derived fibroblasts from NBS patients were reprogrammed into induced pluripotent stem cells (iPSCs) in order to bypass premature senescence. The influence of antioxidants on intracellular levels of ROS and DNA damage were screened and it was found that EDHB-an activator of the hypoxia pathway, decreased DNA damage in the presence of high oxidative stress...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28776711/relating-quality-of-life-to-outcomes-and-predictors-in-adult-cochlear-implant-users-are-we-measuring-the-right-things
#14
Aaron C Moberly, Michael S Harris, Lauren Boyce, Kara Vasil, Taylor Wucinich, David B Pisoni, Jodi Baxter, Christin Ray, Valeriy Shafiro
OBJECTIVE: Current clinical outcome measures for adults receiving cochlear implants (CIs) consist of word and sentence recognition, primarily under quiet conditions. However, these measures may not adequately reflect patients' CI-specific quality of life (QOL). This study first examined traditional auditory-only speech recognition measures and other potentially relevant auditory measures as correlates of QOL in CI users. Second, scores on nonauditory tasks of language and cognition were examined as potential predictors of QOL...
August 4, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28771842/challenges-in-interprofessional-collaboration-experiences-of-care-providers-and-policymakers-in-a-newly-set-up-dutch-assault-centre
#15
Elza Zijlstra, Sylvie Lo Fo Wong, Anne Teerling, Giel Hutschemaekers, Antoine Lagro-Janssen
BACKGROUND: Sexual and family violence are problems that affect many women and men, and the negative health consequences of violence are numerous. As adequate acute interprofessional care can prevent negative health consequences and improve forensic medical examination, a Centre for Sexual and Family Violence was set up. AIM: We aimed to improve our understanding of the challenges in interprofessional collaboration in a newly set-up centre for sexual and family violence...
August 3, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28738319/meeting-report-intercellular-interactions-in-context-towards-a-mechanistic-understanding-of-cells-in-organs
#16
David Bryant, Aaron Johnson
The Company of Biologists held the workshop 'Intercellular interactions in context: towards a mechanistic understanding of cells in organs' at historic Wiston House in West Sussex, UK, 5-8 February 2017. The meeting brought together around 30 scientists from disparate backgrounds - yet with a common interest of how tissue morphogenesis occurs and its dysregulation leads to pathologies - to intensively discuss their latest research, the current state of the field, as well as any challenges for the future. This report summarises the concepts and challenges that arose as key questions for the fields of cell, cancer and developmental biology...
July 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28738236/early-predictors-of-study-success-in-a-dutch-advanced-nurse-practitioner-education-program-a-retrospective-cohort-study
#17
Ercolie R Bossema, Tineke H J M Meijs, Jeroen W B Peters
BACKGROUND: Study delay and attrition are major concerns in higher education. They cost time and effort, and threaten the availability of higher qualified professionals. Knowing early what factors contribute to delay and attrition may help prevent this. OBJECTIVE: The aim of this study was to examine whether student characteristics, including a literature study report grade as a proxy of cognitive abilities, predicted study success in a dual advanced nurse practitioner education program...
October 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28734169/development-and-psychometric-validation-of-the-headache-screening-questionnaire-dutch-version
#18
Hedwig A van der Meer, Corine M Visscher, Raoul H H Engelbert, Wim M Mulleners, Maria W G Nijhuis-van der Sanden, Caroline M Speksnijder
BACKGROUND: Headache is a common disorder which may lead to substantial socio-economic loss. Treatment options include self-management strategies, medication and physiotherapy. Physiotherapists need to be able to screen for the presence of migraine and tension-type headache (TTH), so they can adjust their treatment strategies to the type of headache. A quick screening questionnaire to recognize migraine and TTH in the physiotherapy practice is needed. OBJECTIVE: The aim of this study was to create a headache screening questionnaire based on the ICHD-3 beta criteria for migraine and TTH, and to establish its content and criterion validity...
July 4, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28728951/quality-of-life-and-cochlear-implant-results-in-adults-with-postlingual-hearing-loss
#19
Aline Faria de Sousa, Maria Inês Vieira Couto, Ana Claudia Martinho-Carvalho
INTRODUCTION: Considering the variability of results found in the clinical population using a cochlear implant, researchers in the area have been interested in the inclusion of quality of life measures to subjectively assess the benefits of the implantation. OBJECTIVE: To assess the quality of life of adult users of cochlear implant. METHODS: A cross-sectional and clinical study in a group of 26 adults of both genders, with mean duration of cochlear implant use of 6...
July 5, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28699806/fibromyalgia-as-a-cause-of-uncontrolled-asthma-a-case-controlled-multicenter-study
#20
Eva Martinez-Moragon, V Plaza, Isabel Torres, Ana Rosado, Isabel Urrutia, Xavier Casas, Belen Hinojosa, Marina Blanco-Aparicio, Julio Delgado, Santiago Quirce, Carles Sabadell, Pilar Cobellero, Ana Muñoz-Fernández
BACKGROUND: Fibromyalgia can affect the control of asthma when both diseases are present in a single patient. OBJECTIVES: To characterize asthma in patients with concomitant fibromyalgia to assess whether fibromyalgia is an independent factor of asthma severity that influences upon poor asthma control. We also evaluated how dyspnea is perceived by the patients in order to demonstrate that alterations in the perception of airway obstruction may be responsible for poor asthma control...
July 12, 2017: Current Medical Research and Opinion
keyword
keyword
9218
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"