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https://www.readbyqxmd.com/read/27910983/investigation-and-intervention-of-autophagy-to-guide-cancer-treatment-with-nanogels
#1
Xudong Zhang, Xin Liang, Jianjun Gu, Danfeng Chang, Jinxie Zhang, Zhaowei Chen, Yanqi Ye, Chao Wang, Wei Tao, Xiaowei Zeng, Gan Liu, Yongjun Zhang, Lin Mei, Zhen Gu
Cancer cells use autophagy to resist poor survival environmental conditions such as low PH, poor nutrients as well as chemical therapy. Nanogels have been used as efficient chemical drug carriers for cancer treatment. However, the effect of nanogels on autophagy is still unknown. Here, we used Rab proteins as the marker of multiple trafficking vesicles in endocytosis and LC3 as the marker of autophagy to investigate the intracellular trafficking network of Rhodamine B (Rho)-labeled nanogels. The nanogels were internalized by the cells through multiple protein dependent endocytosis and micropinocytosis...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27909548/microvasculature-of-the-esophagus-and-gastroesophageal-junction-lesson-learned-from-submucosal-endoscopy
#2
REVIEW
Roberta Maselli, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Esperanza Grace Santi, Hiroki Sato, Bu'Hussain Hayee, Shin-Ei Kudo
Advanced therapeutic endoscopy, in particular endoscopic mucosal resection, endoscopic submucosal dissection, per-oral endoscopic myotomy, submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible. Combining these information with advanced diagnostic endoscopy, the esophagus is organized, from the luminal side to outside, into five layers (epithelium, lamina propria with lamina muscularis mucosa, submucosa, muscle layer, adventitia). A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and, at the lower esophageal sphincter (LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; peri-esophageal veins in adventitia...
November 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27908978/potential-of-laboratory-execution-systems-less-to-simplify-the-application-of-business-process-management-systems-bpmss-in-laboratory-automation
#3
Sebastian Neubert, Bernd Göde, Xiangyu Gu, Norbert Stoll, Kerstin Thurow
Modern business process management (BPM) is increasingly interesting for laboratory automation. End-to-end workflow automation and improved top-level systems integration for information technology (IT) and automation systems are especially prominent objectives. With the ISO Standard Business Process Model and Notation (BPMN) 2.X, a system-independent and interdisciplinary accepted graphical process control notation is provided, allowing process analysis, while also being executable. The transfer of BPM solutions to structured laboratory automation places novel demands, for example, concerning the real-time-critical process and systems integration...
December 1, 2016: Journal of Laboratory Automation
https://www.readbyqxmd.com/read/27882718/catching-up-or-falling-behind-continuing-wealth-disparities-for-immigrants-to-canada-by-region-of-origin-and-cohort
#4
Michelle Maroto, Laura Aylsworth
This paper investigates wealth disparities among first-generation immigrants using data from the 2012 Survey of Financial Security. We apply logistic and linear regression models to estimate disparities in homeownership and household equivalent net worth by immigrant status, region of origin, and time since arrival. By focusing on immigrant families from different regions who entered Canada at different points in time, this research applies theories related to assimilation, human capital, and structural barriers to wealth...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27882715/factors-influencing-church-choice-an-exploration-of-responses-from-new-attendees-at-growing-canadian-mainline-churches
#5
David Millard Haskell, Stephanie Burgoyne, Kevin N Flatt
Seventy new attendees of growing Mainline Protestant churches in Canada agreed to be interviewed regarding what attracted them to, and kept them at, their current congregation. A variety of responses revealed that, in part, the new attendees were drawn to their Mainline Protestant church by aspects of Conservative Protestant theology. Contemporary theories of group membership are used to explore the links between Conservative Protestant theology, group cohesion, and, to a lesser extent, church growth. Soixante-dix nouveaux participants provenant d'une église protestante traditionnelle au Canada en croissance ont accepté d'être interviewés au sujet des caractéristiques qui les ont attirés et qui les ont gardés à leur congrégation actuelle...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27882710/john-porter-book-prize-lecture-bringing-the-social-back-in-on-the-integration-of-muslim-immigrants-and-the-jurisprudence-of-muslim-minorities
#6
Abdolmohammad Kazemipur
In much of the academic debate on the integration of Muslims into Western liberal democracies, Islam is often treated as one or the sole independent variable in the lives of Muslims. Offering to view Islam-or the understanding of Islam among Muslims-as the dependent variable, The Muslim Question in Canada discusses the influence of socioeconomic forces in shaping the Muslim immigrants' opinions, modes of thinking, and even interpretations of their faith. Drawing on this general approach, which is introduced and developed in the book using a variety of both quantitative and qualitative data, this article focuses on a school of thought within the Islamic jurisprudence known as fiqh al-aqalliyyat al-Muslema (the jurisprudence of Muslim minorities)...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27874910/short-versus-long-cephalomedullary-nails-for-pertrochanteric-hip-fracture
#7
Nicholas B Frisch, Nickolas J Nahm, Jad G Khalil, Clifford M Les, Stuart T Guthrie, Michael A Charters
This study compared patients who underwent treatment with short or long cephalomedullary nails with integrated cephalocervical screws and linear compression. Patients with AO/OTA 31-A2 or A3 pertrochanteric fractures treated with either short (n=72) or long (n=97) InterTAN (Smith & Nephew, Memphis, Tennessee) cephalomedullary nails were reviewed. Information on perioperative measures (estimated blood loss, surgical time, and fluoroscopy time) and postoperative orthopedic complications (infection, implant failure, screw cutout, and periprosthetic femur fracture) was included...
November 22, 2016: Orthopedics
https://www.readbyqxmd.com/read/27866639/innovation-within-a-university-setting
#8
Elisabeth K Wynne, Thomas M Krummel
Elisabeth K. Wynne, MD, completed her undergraduate degree in bioengineering and is currently a surgical resident in training at the University of Washington. From 2014-2016, she served as a Biodesign Fellow at Stanford University. She plans to pursue a career of innovation as an academic surgeon. Thomas M. Krummel, MD, is the Emile Holman Professor and Chair Emeritus of the Department of Surgery at Stanford University School of Medicine. Throughout his career, Dr Krummel has been a pioneer and an innovator...
December 2016: Surgery
https://www.readbyqxmd.com/read/27865290/pneumatic-dilation-of-the-lower-esophageal-sphincter-can-now-be-successfully-performed-without-morbidity
#9
Yi Jia, Marco Bustamante, Sharareh Moraveji, Richard W McCallum
BACKGROUND: Patients with dysphagia may be diagnosed with impaired lower esophageal sphincter (LES) relaxation and treated with pneumatic dilation (PD), stretching and tearing LES muscle fibers. Esophageal perforation has been reported to be as high as 10%. We conducted a retrospective study to evaluate the perforation rate of PD when used for impaired relaxation of the LES using current techniques. METHODS: A chart review was conducted to identify patients referred for esophageal manometry by high-resolution manometry and later received PD from January 2013 to April 2016...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27862648/accuracy-of-the-air-flow-sphincter-locator-system-in-identifying-the-lower-esophageal-sphincter-for-placement-of-ph-catheters
#10
Joan W Chen, Jason R Baker, Jessica M Compton, Mark McDermott, Joel H Rubenstein
The Air Flow Sphincter Locator (AFSL) is marketed as an alternative method to manometry for localizing the lower esophageal sphincter (LES) for pH probe placement. Such a system is desirable due to the additional time, cost, and discomfort associated with dual nasal intubation, but its accuracy has never been assessed. To assess the accuracy of the AFSL in localizing the LES. Fifty consecutive outpatients presenting for pH and manometry studies were included. The upper border of the LES was determined using HRM and the AFSL by two technicians independently...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27855683/validation-of-the-clutter-image-rating-cir-scale-among-psychiatric-outpatients-in-singapore
#11
Vathsala Sagayadevan, Ying Wen Lau, Clarissa Ong, Siau Pheng Lee, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: The Clutter Image Rating (CIR) Scale though extensively used to assess hoarding behavior, has mainly been validated in Western populations. METHODS: The current study sought to validate the CIR in a sample of psychiatric outpatients (n = 500) in Singapore. Convergent and divergent validity as well as inter-observer reliabilities between participant CIR and interviewer-rated CIR were calculated. RESULTS: The CIR performed fairly in identifying participants with and without hoarding problems according to the Savings Inventory Revised (SI-R)...
November 17, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27853819/sur-les-processus-lin%C3%A3-aires-de-naissance-et-de-mort-sous-critiques-dans-un-environnement-al%C3%A3-atoire
#12
Nicolas Bacaër
An explicit formula is found for the rate of extinction of subcritical linear birth-and-death processes in a random environment. The formula is illustrated by numerical computations of the eigenvalue with largest real part of the truncated matrix for the master equation. The generating function of the corresponding eigenvector satisfies a Fuchsian system of singular differential equations. A particular attention is set on the case of two environments, which leads to Riemann's differential equation.
November 16, 2016: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/27848931/serum-albumin-and-c-reactive-protein-albumin-ratio-are-useful-biomarkers-of-crohn-s-disease-activity
#13
Guangming Qin, Jiangfeng Tu, Lingang Liu, Laisheng Luo, Jiaqi Wu, Lisha Tao, Chenjing Zhang, Xiaoge Geng, Xiaojun Chen, Xinbo Ai, Bo Shen, Wensheng Pan
BACKGROUND Serum albumin (ALB) may be low during acute inflammation, but it is also affected by nutritional status. Therefore, we hypothesized that ALB and the C-reactive protein/ALB ratio (CRP/ALB) may be associated with disease activity in patients with Crohn's disease (CD). MATERIAL AND METHODS Altogether, 100 patients with CD and 100 age- and sex-matched healthy volunteers were retrospectively enrolled in the current study. The patients with CD were subdivided into patients with active disease (Crohn's Disease Activity Index >150) and those in remission...
November 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27844476/coprescribing-naloxone-for-patients-on-chronic-opioid-therapy-les-sons-learned-from-a-patient-safety-initiative-in-primary-care-training-sites
#14
William Delaney, Jessica Huff, Sandra Mini, Aiswarya Thomas, Ralph Tremaglio
OBJECTIVE: To describe the development and implementation of a resident-led effort to increase coprescription of naloxone in a primary care setting. DESIGN: An exploratory, prospective pilot project to increase coprescription rates of naloxone. SETTING: Four primary care offices in western Connecticut serving as medical home training sites for primary care residents. PATIENTS, PARTICIPANTS: All patients on chronic opioid therapy...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27822379/removal-of-micropollutants-through-a-biological-wastewater-treatment-plant-in-a-subtropical-climate-queensland-australia
#15
Miguel Antonio Reyes Cardenas, Imtiaj Ali, Foon Yin Lai, Les Dawes, Ricarda Thier, Jay Rajapakse
BACKGROUND: Municipal wastewaters contain a multitude of organic compounds derived from domestic and industrial sources including active components of pharmaceutical and personal care products and compounds used in agriculture, such as pesticides, or food processing such as artificial sweeteners often referred to as micropollutants. Some of these compounds or their degradation products may have detrimental effects on the environment, wildlife and humans. Acesuflame is one of the most popular artificial sweeteners to date used in foodstuffs...
2016: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/27817814/exercise-induced-bronchoconstriction-in-athletes-a-qualitative-assessment-of-symptom-perception
#16
Oliver J Price, James H Hull, Les Ansley, Mike Thomas, Caroline Eyles
BACKGROUND: A poor relationship between perceived respiratory symptoms and objective evidence of exercise-induced bronchoconstriction (EIB) in athletes is often reported; however, the reasons for this disconnect remain unclear. The primary aim of this study was to utilise a qualitative-analytical approach to compare respiratory symptoms in athletes with and without objectively confirmed EIB. METHODS: Endurance athletes who had previously undergone bronchoprovocation test screening for EIB were divided into sub-groups, based on the presence or absence of EIB ± heightened self-report of dyspnoea: (i) EIB-Dys- (ii) EIB + Dys+ (iii) EIB + Dys- (iv) EIB-Dys+...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27817003/obstructive-ventilatory-disorder-in-heart-failure-caused-by-the-heart-or-the-lung
#17
REVIEW
Sergio Caravita, Jean-Luc Vachiéry
Heart failure (HF) is a clinical syndrome frequently associated with airway obstruction, either as a respiratory comorbidity or as a direct consequence of HF pathophysiology. Recognizing the relative contribution of an underlying airway disease as opposed to airway obstruction due to volume overload and left atrial pressure elevation is of importance for the appropriate management of patients affected by HF. This review focuses on "les liaisons dangereuses" between the heart and the lungs, outlying recent advances linking in a vicious circle of chronic obstructive lung disease (COPD) and obstructive sleep apnea (OSA) on one side and HF on the other side...
November 5, 2016: Current Heart Failure Reports
https://www.readbyqxmd.com/read/27810720/the-recovery-index-a-novel-approach-to-measuring-recovery-and-predicting-remission-in-major-depressive-disorder
#18
Waguih William IsHak, Wes Bonifay, Katherine Collison, Mark Reid, Haidy Youssef, Thomas Parisi, Robert M Cohen, Li Cai
BACKGROUND: Clinicians view "recovery" as the reduction in severity of symptoms over time, whereas patients view it as the restoration of premorbid functioning level and quality of life (QOL). The main purpose of this study is to incorporate patient-reported measures of functioning and QOL into the assessment of patient outcomes in MDD and to use this data to define recovery. METHOD: Using the STAR*D study of patients diagnosed with MDD, this present analysis grades patients' MDD severity, functioning level, and QOL at exit from each level of the study, as well as at follow-up...
October 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27807864/integrated-approach-to-reduce-perinatal-adverse-events-standardized-processes-interdisciplinary-teamwork-training-and-performance-feedback
#19
William Riley, James W Begun, Les Meredith, Kristi K Miller, Kathy Connolly, Rebecca Price, Janet H Muri, Mac McCullough, Stanley Davis
OBJECTIVE: To improve safety practices and reduce adverse events in perinatal units of acute care hospitals. DATA SOURCES: Primary data collected from perinatal units of 14 hospitals participating in the intervention between 2008 and 2012. Baseline secondary data collected from the same hospitals between 2006 and 2007. STUDY DESIGN: A prospective study involving 342,754 deliveries was conducted using a quality improvement collaborative that supported three primary interventions...
November 3, 2016: Health Services Research
https://www.readbyqxmd.com/read/27807221/la-bio%C3%A3-thique-la-r%C3%A3-%C3%A3-valuation-des-technologies-de-la-sant%C3%A3-et-la-gestion
#20
REVIEW
Lesley J J Soril, Fiona M Clement, Tom W Noseworthy
La réévaluation des technologies de la santé (RTS), ce domaine émergent des services de santé et des recherches stratégiques, favorise la prise en charge optimale des technologies pendant toute leur vie utile. La RTS, qui est une évaluation structurée et fondée sur des données probantes des effets cliniques, économiques, sociaux et éthiques des technologies en place, permet de faire une utilisation optimale de ces technologies, d'en prévoir le retrait progressif et de mieux rentabiliser celles qui sont utilisées dans le milieu de la santé...
November 2016: Healthcare Management Forum
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