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https://www.readbyqxmd.com/read/29053142/resolution-of-inflammation-and-sepsis-survival-are-improved-by-dietary-%C3%AE-3-fatty-acids
#1
Andreas Körner, Martin Schlegel, Julia Theurer, Hannes Frohnmeyer, Michael Adolph, Marieke Heijink, Martin Giera, Peter Rosenberger, Valbona Mirakaj
Critical conditions such as sepsis following infection or traumatic injury disturb the complex state of homeostasis that may lead to uncontrolled inflammation resulting in organ failure, shock and death. They are associated with endogenous mediators that control the onset of acute inflammatory response, but the central problem remains the complete resolution of inflammation. Omega-3 enriched lipid emulsions (Ω-3(+) LEs) were used in experimental studies and clinical trials to establish homeostasis, yet with little understanding about their role on the resolution of inflammation and tissue regeneration...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29039175/-comparison-of-limus-eluting-stent-with-paclitaxel-eluting-stent-for-patients-with-coronary-small-vessel-disease-a-systematic-review-and-meta-analysis
#2
Xiaoqun Zhang, Qiwen Wang, Xin Wang, Xiaolei Xu, Jianhua Zhu
OBJECTIVE: To compare the efficacy of limus-eluting stent (LES) with paclitaxel-eluting stent (PES) for patients with coronary small vessel disease. METHODS: The studies of LES and PES used for patients with coronary small vessel disease were searched in PubMed, Web of Science, ClinicalTrials, SinoMed, CNKI, Wanfang data and CQVIP. The relative risk (RR) estimates with 95% confidence intervals and other statistical variables were calculated with Stata 14.0, and the meta analysis was performed with RevMan 5...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29039034/inactivation-of-nsf-atpase-leads-to-cathepsin-b-release-after-transient-cerebral-ischemia
#3
Dong Yuan, Chunli Liu, Bingren Hu
Neurons have extraordinary large cell membrane surface area, thus requiring extremely high levels of intracellular membrane-trafficking activities. Consequently, defects in the membrane-trafficking activities preferentially affect neurons. A critical molecule for controlling the membrane-trafficking activities is the N-ethylmaleimide-sensitive factor (NSF) ATPase. This study is to investigate the cascade of events of NSF ATPase inactivation, resulting in a massive buildup of late endosomes (LEs) and fatal release of cathepsin B (CTSB) after transient cerebral ischemia using the 2-vessel occlusion with hypotension (2VO+Hypotension) global brain ischemia model...
October 17, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29038797/anthocyanin-profile-antioxidant-activity-and-enzyme-inhibiting-properties-of-blueberry-and-cranberry-juices-a-comparative-study
#4
Guillermo Cásedas, Francisco Les, María Pilar Gómez-Serranillos, Carine Smith, Víctor López
Cranberry (Vaccinium macrocarpon) and blueberry (Vaccinium myrtillus) juices are commonly consumed as a source of antioxidants. The aim of this study was to compare bioactivities as well as the differences in the polyphenol content and anthocyanin profile of both juices. Polyphenol and anthocyanin contents were quantified using spectrophotometric and chromatographic methods. Bioassays were carried out in terms of antioxidant properties in cell and cell free systems as well as inhibition of physiological enzymes that are targets involved in the prevention of chronic diseases (monoamine oxidase A, tyrosinase, acetylcholinesterase, α-glucosidase and dipeptidyl peptidase-4)...
October 17, 2017: Food & Function
https://www.readbyqxmd.com/read/29034312/tgf-%C3%AE-inhibition-improves-oncolytic-herpes-viroimmunotherapy-in-murine-models-of-rhabdomyosarcoma
#5
Brian Hutzen, Chun-Yu Chen, Pin-Yi Wang, Les Sprague, Hayley M Swain, Julia Love, Joe Conner, Louis Boon, Timothy P Cripe
Oncolytic viruses are an emerging class of cancer therapeutics that couple cytotoxicity with the induction of an anti-tumor immune response. Host-virus interactions are complex and modulated by a tumor microenvironment whose immunosuppressive activities can limit the effectiveness of cancer immunotherapies. In an effort to improve this aspect of oncolytic virotherapy, we combined the oncolytic herpes virus HSV1716 with the transforming growth factor beta receptor 1 (TGF-βR1) inhibitor A8301 to treat syngeneic models of murine rhabdomyosarcoma...
December 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/29032347/vocalic-transitions-as-markers-of-speech-acoustic-changes-with-stn-dbs-in-parkinson-s-disease
#6
Vincent Martel-Sauvageau, Kris Tjaden
PURPOSE: Deep Brain Stimulation of the subthalamic nucleus (STN-DBS) effectively treats cardinal symptoms of idiopathic Parkinson's disease (PD) that cannot be satisfactorily managed with medication. Research is equivocal regarding speech changes associated with STN-DBS. This study investigated the impact of STN-DBS on vocalic transitions and the relationship to intelligibility. METHODS: Eight Quebec-French speakers with PD and eight healthy controls participated...
October 7, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29031063/anticancer-properties-of-4-thiazolidinone-derivatives-depend-on-peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE
#7
Konrad A Szychowski, Marcin L Leja, Danylo V Kaminskyy, Anna P Kryshchyshyn, Urszula E Binduga, Oleh R Pinyazhko, Roman B Lesyk, Jakub Tobiasz, Jan Gmiński
Peroxisome proliferator-activated receptors (PPARs) play an important role in numerous chronic diseases such as diabetes, obesity, atherosclerosis and cancer, and PPAR modulators are among the approved drugs and drug-candidates for their treatment. The aim of this study was to elucidate the involvement of PPARs in the mechanism of cytotoxic and pro-apoptotic action of novel anticancer 4-thiazolidinone derivatives (Les-2194, Les-3377, Les-3640) and approved 4-thiazolidinones (Rosiglitazone, Pioglitazone) towards the human squamous carcinoma (SCC-15) cell line...
September 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29030643/three-dimensional-myoarchitecture-of-the-lower-esophageal-sphincter-and-esophageal-hiatus-using-optical-sectioning-microscopy
#8
Ali Zifan, Dushyant Kumar, Leo K Cheng, Ravinder K Mittal
Studies to date have failed to reveal the anatomical counterpart of the lower esophageal sphincter (LES). We assessed the LES and esophageal hiatus morphology using a block containing the human LES and crural diaphragm, serially sectioned at 50 μm intervals and imaged at 8.2 μm/pixel resolution. A 3D reconstruction of the tissue block was reconstructed in which each of the 652 cross sectional images were also segmented to identify the boundaries of longitudinal (LM) and circular muscle (CM) layers. The CM fascicles on the ventral surface of LES are arranged in a helical/spiral fashion...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29027729/application-of-bayesian-analysis-to-the-doubly-labelled-water-method-for-total-energy-expenditure-in-humans
#9
Yue Ruan, Les Bluck, James Smith, Adrian Mander, Priya Singh, Michelle Venables
RATIONALE: The doubly labelled water (DLW) method is the reference method for the estimation of free-living total energy expenditure (TEE). In this method, where both (2) H and (18) O are employed, different approaches have been adopted to deal with the non-conformity observed regarding the distribution space for the labels being non-coincident with total body water. However, the method adopted can have a significant effect on the estimated TEE. METHODS: We proposed a Bayesian reasoning approach to modify an assumed prior distribution for the space ratio using experimental data to derive the TEE...
October 13, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29026876/avoiding-icu-admission-by-using-a-fast-track-protocol-is-safe-in-selected-adult-to-adult-live-donor-liver-transplant-recipients
#10
Juan Echeverri, Nicolas Goldaracena, Akhil Kant Singh, Gonzalo Sapisochin, Nazia Selzner, Mark S Cattral, Paul D Greig, Les Lilly, Ian D McGilvray, Gary A Levy, Anand Ghanekar, Eberhard L Renner, David R Grant, Stuart A McCluskey, Markus Selzner
BACKGROUND: We evaluated patient characteristics of live donor liver transplant (LDLT) recipients undergoing a fast-track protocol without intensive care unit (ICU) admission versus LDLT patients receiving posttransplant ICU care. METHODS: Of the 153 LDLT recipients, 46 patients were included in our fast-track protocol without ICU admission. Both, fast-tracked patients and ICU-admitted patients were compared regarding donor and patient characteristics, perioperative characteristics, and postoperative outcomes and complications...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29022237/dysfunction-of-membrane-trafficking-leads-to-ischemia-reperfusion-injury-after-transient-cerebral-ischemia
#11
REVIEW
Dong Yuan, Chunli Liu, Bingren Hu
Neurons require an extraordinarily high level of membrane trafficking activities because of enriched axonal terminals and dendritic branches. For that reason, defects in the membrane trafficking pathway are a hallmark of most, and may be all, neurodegenerative disorders. A major cellular membrane trafficking pathway is the Golgi apparatus (Golgi hereafter)-late endosome-lysosome axis for supplying lysosomal enzymes. This pathway is regulated by N-ethylmaleimide-sensitive factor (NSF) ATPase. This review article is to discuss a novel hypothesis that brain ischemia inactivates NSF ATPase, resulting in a cascade of events of disruption of the Golgi-endosome-lysosome pathway, release of cathepsin B (CTSB), and induction of mitochondrial outer membrane permeabilization (MOMP) during the postischemic phase...
October 11, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29021697/chronic-saponin-treatment-attenuates-damage-to-the-pancreas-in-chronic-alcohol-treated-diabetic-rats
#12
Mi Ran Choi, Su Min Kwak, Sol Hee Bang, Jo-Eun Jeong, Dai-Jin Kim
BACKGROUND: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats. METHODS: Long-Evans Tokushima Fatty (LETO) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats were pair-fed a Lieber-DeCarli diet with and without 5% ethanol for 12 wks...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29019565/sleeve-gastrectomy-and-fundoplication-as-a-single-procedure-in-patients-with-obesity-and-gastroesophageal-reflux
#13
Juan Pablo Lasnibat, Italo Braghetto, Luis Gutierrez, Felipe Sanchez
BACKGROUND: Bariatric surgery in Chile has seen an exponential increase in recent years, especially in sleeve gastrectomy. Its use is currently discussed in patients suffering from gastroesophageal reflux disease. Different options have been considered for the management of these patients but up to now laparoscopic Roux-en-Y gastric bypass seems to be the best option. Sleeve gastrectomy plus concomitant fundoplication or hiatal hernia repair also has been suggested in patients having reflux or small hiatal hernia...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28988168/how-information-about-overdetection-changes-breast-cancer-screening-decisions-a-mediation-analysis-within-a-randomised-controlled-trial
#14
Jolyn Hersch, Kevin McGeechan, Alexandra Barratt, Jesse Jansen, Les Irwig, Gemma Jacklyn, Nehmat Houssami, Haryana Dhillon, Kirsten McCaffery
OBJECTIVES: In a randomised controlled trial, we found that informing women about overdetection changed their breast screening decisions. We now present a mediation analysis exploring the psychological pathways through which study participants who received the intervention processed information about overdetection and how this influenced their decision-making. We examined a series of potential mediators in the causal chain between exposure to overdetection information and women's subsequently reported breast screening intentions...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28977739/denonvilliers-fascia-in-men-a-sheet-plastination-and-confocal-microscopy-study-of-the-prerectal-space-and-the-presence-of-an-optimal-anterior-plane-when-mobilizing-the-rectum-for-cancer
#15
Zhaoyang Xu, Pierre H Chapuis, Les Bokey, Ming Zhang
AIM: The aim of this study was to investigate the detailed, in situ, morphology of Denonvilliers fascia (DVF) in cadavers using sheet plastination and confocal microscopy and to review and describe the optimal anterior plane for mobilisation of the distal rectum.. METHOD: Six, male cadavers (age range, 46-87 years) were prepared as six sets of transverse (x2), coronal (x1) and sagittal (x3) plastinated sections which were examined under a confocal laser scanning microscope...
October 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28975832/systemic-and-adjuvant-therapies-for-intrahepatic-cholangiocarcinoma
#16
Yun Shin Chun, Milind Javle
Intrahepatic cholangiocarcinoma represents the second most common primary liver cancer and is increasing in incidence. Most patients are diagnosed at an advanced, nonsurgical stage and only about 1 in 5 cases are surgically resectable. Despite surgery, the 5-year survival is low at only 30%. Multifocal, node- or margin-positive disease is at a higher risk of recurrence after resection. There is no level 1 evidence in support of postoperative adjuvant therapy. A recent adjuvant therapy phase III trial from the Partenariat de Recherche en Oncologie Digestive-Actions Concertées dans les Cancers Colo-Rectaux et Digestifs (PRODIGE) group reported no survival advantage with adjuvant gemcitabine and oxaliplatin therapy...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28971688/-les-carot%C3%A3-no%C3%A3-des-s%C3%A3-riques-comme-biomarqueurs-une-strat%C3%A3-gie-pour-am%C3%A3-liorer-la-validit%C3%A3-de-l-%C3%A3-valuation-alimentaire
#17
Jacynthe Lafrenière, Charles Couillard, Benoît Lamarche, Simone Lemieux
No abstract text is available yet for this article.
October 3, 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/28969656/inadequate-programming-insufficient-communication-and-non-compliance-with-the-basic-principles-of-maternal-death-audits-in-health-districts-in-burkina-faso-a-qualitative-study
#18
Boukaré Congo, Djénéba Sanon, Tieba Millogo, Charlemagne Marie Ouedraogo, Wambi Maurice E Yaméogo, Ziemlé Clement Meda, Seni Kouanda
BACKGROUND: Implementation of quality maternal death audits requires good programming, good communication and compliance with core principles. Studies on compliance with core principles in the conduct of maternal death audits (MDAs) exist but were conducted in urban areas, at the 2nd or 3rd level of the healthcare system, in experimental situations, or in a context of skills-building projects or technical platforms with an emphasis on the review of "near miss". This study aims to fill the gap of evidence on the implementation of MDAs in rural settings, at the first level of care and in the routine care situation in Burkina Faso...
September 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28967199/levels-and-determinants-of-breast-and-cervical-cancer-screening-uptake-in-hiv-infected-women-compared-with-the-general-population-in-france
#19
L Tron, F Lert, B Spire, R Dray-Spira
OBJECTIVES: Cancer is a growing concern for HIV-infected people, and screening plays a major role in alleviating the burden it causes. We sought to investigate the levels and determinants of breast cancer screening (BCS) and cervical cancer screening (CCS) in HIV-infected women as compared with the general population. METHODS: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study was conducted in 2011 in a national representative sample of 3022 HIV-infected hospital out-patients in France...
March 2017: HIV Medicine
https://www.readbyqxmd.com/read/28958969/nocardiose-cutan%C3%A3-e-chez-une-patiente-immunocomp%C3%A3-tente-a-propos-d-un-cas-et-revue-de-la-litt%C3%A3-rature
#20
Alexandre Tang, Anaëlle Muggeo, Boris Rihn, Marie Catherine Thiercelin, Lucien Brasme, Christophe de Champs, Thomas Guillard
Nocardia spp. est responsable d'infections opportunistes chez les patients immunodéprimés, principalement d'infections pulmonaires. Le système nerveux central est la localisation extra-pulmonaire la plus souvent retrouvée. Nous rapportons ici un cas d'infection cutanée à N. brasiliensis chez une patiente immunocompétente, ainsi qu'une revue de la littérature.
October 1, 2017: Annales de Biologie Clinique
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