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https://www.readbyqxmd.com/read/29684661/effects-of-vitamin-d-supplementation-on-adherence-to-and-persistence-with-long-term-statin-therapy-secondary-analysis-from-the-randomized-double-blind-placebo-controlled-vida-study
#1
Zhenqiang Wu, Carlos A Camargo, Kay-Tee Khaw, Debbie Waayer, Carlene M M Lawes, Les Toop, Robert Scragg
BACKGROUND AND AIMS: Long-term statin use increases survival. However, the adherence to and persistence with statin use are challenging and this influences the success of statin treatment. Our aim was to explore if monthly vitamin D supplementation (100,000-IU) improves the adherence to and persistence with long-term statin use in older adults. METHODS: We conducted a secondary analysis of a trial comparing data on dispensed statin prescriptions, between participants allocated to vitamin D supplementation or placebo, for those taking statin therapy...
April 7, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29677450/complete-programmable-decoding-of-oxidized-5-methylcytosine-nucleobases-in-dna-by-chemoselective-blockage-of-universal-tale-binders
#2
Mario Giess, Anna Witte, Julia Jasper, Oliver Koch, Daniel Summerer
5-methylcytosine (5mC) and its oxidized derivatives are regulatory elements of mammalian genomes involved in development and disease. These nucleobases do not selectively modulate Watson-Crick pairing, preventing their programmable targeting and analysis by traditional hybridiza-tion probes. Transcription-activator-like effectors (TALEs) can be engineered for use as programmable probes with epi-genetic nucleobase selectivity. However, only partial selectivi-ties for oxidized 5mC have been achieved so far, preventing unambiguous target binding...
April 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29669535/assessment-of-subjective-emotional-valence-and-long-lasting-impact-of-life-events-development-and-psychometrics-of-the-stralsund-life-event-list-sel
#3
Johanna König, Andrea Block, Mathias Becker, Kristin Fenske, Johannes Hertel, Sandra Van der Auwera, Kathleen Zymara, Henry Völzke, Harald Jürgen Freyberger, Hans Jörgen Grabe
BACKGROUND: Life events (LEs) are associated with future physical and mental health. They are crucial for understanding the pathways to mental disorders as well as the interactions with biological parameters. However, deeper insight is needed into the complex interplay between the type of LE, its subjective evaluation and accompanying factors such as social support. The "Stralsund Life Event List" (SEL) was developed to facilitate this research. METHODS: The SEL is a standardized interview that assesses the time of occurrence and frequency of 81 LEs, their subjective emotional valence, the perceived social support during the LE experience and the impact of past LEs on present life...
April 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29662079/author-correction-new-insights-into-gelatinization-mechanisms-of-cereal-endosperm-starches
#4
Shujun Wang, Chen Chao, Fengjuan Xiang, Xiu Zhang, Shuo Wang, Les Copeland
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29659597/measuring-movement-into-residential-care-institutions-in-haiti-after-hurricane-matthew-a-pilot-study
#5
Beth L Rubenstein, Matthew MacFarlane, Celina Jensen, Lindsay Stark
BACKGROUND: Governments have an ethical imperative to safeguard children in residential care institutions at all times, including in the aftermath of an emergency. Yet, a lack of accurate data about how the magnitude and characteristics of this population may change due to an emergency impedes leaders' ability to formulate responsive policies and services, mobilize resources and foster accountability. The purpose of this study was therefore to determine the feasibility of evaluating movement of children into residential care following an emergency...
2018: PloS One
https://www.readbyqxmd.com/read/29649888/factors-affecting-occupational-therapists-decision-to-join-their-regional-professional-association-facteurs-influen%C3%A3-ant-la-d%C3%A3-cision-des-ergoth%C3%A3-rapeutes-de-joindre-les-rangs-de-leur-association-professionnelle-r%C3%A3-gionale
#6
Angelica N Reyes, Cary A Brown
BACKGROUND: Voluntary occupational therapy organizations fill an important role. However, recruitment and retention can be problematic. Little is known about factors influencing occupational therapists to join/maintain membership in professional associations. PURPOSE: This study investigated factors influencing occupational therapists' decision to join/remain members of their association. METHOD: An electronic survey was carried out and data were analyzed using SPSS software and manual categorization of open-ended comments...
January 1, 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29649002/jak1-2-inhibition-with-baricitinib-in-the-treatment-of-autoinflammatory-interferonopathies
#7
Gina A Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason A Dare, Diane Brown, Deborah L Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A de Jesus, Dawn C Chapelle, Hanna Kim, Samantha Dill, Robert Colbert, Laura Failla, Bahar Kost, Michelle O'Brien, James C Reynolds, Les R Folio, Katherine R Calvo, Scott M Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angélique Biancotto, Edward W Cowen, John G Digiovanna, Massimo Gadina, Andrew J Lipton, Colleen Hadigan, Steven M Holland, Joseph Fontana, Ahmad S Alawad, Rebecca J Brown, Kristina I Rother, Theo Heller, Kristina M Brooks, Parag Kumar, Stephen R Brooks, Meryl Waldman, Harsharan K Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan M Janes, Seza Ozen, Paul G Wakim, Paul A Brogan, William L Macias, Raphaela Goldbach-Mansky
BACKGROUND: Monogenic Interferon (IFN)-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN-response-gene-signature (IRS), inflammatory organ damage and high mortality. We used the janus kinase (JAK) inhibitor baricitinib with IFN-blocking activity in vitro, to ameliorate disease. METHODS: Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 with SAVI (Stimulator of IFN genes (STING)-associated vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an Expanded Access Program...
April 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29644765/correlation-between-novel-3d-high-resolution-manometry-esophagogastric-junction-metrics-and-ph-metry-in-reflux-disease-patients
#8
Y Xiao, Z Lin, Y Li, J E Pandolfino, M Chen, P J Kahrilas
BACKGROUND AND AIMS: We recently developed 2 novel 3D high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) contractility to differentiate the lower esophageal sphincter (LES) and crural diaphragm (CD) elements of EGJ pressure. This study aimed to compare these metrics to the EGJ-contractile integral (EGJ-CI) and to analyze their correlation with esophageal acid exposure time (AET) on pH-metry. METHODS: Thirty-one gastro-oesophageal reflux disease (GERD) patients and 20 control subjects underwent 24-hour pH-metry and HRM using a 3D-HRM catheter...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29644483/studies-of-abnormalities-of-the-lower-esophageal-sphincter-during-esophageal-emptying-based-on-a-fully-coupled-bolus-esophageal-gastric-model
#9
Wenjun Kou, John E Pandolfino, Peter J Kahrilas, Neelesh A Patankar
The aim of this work was to develop a fully coupled bolus-esophageal-gastric model based on the immersed boundary-finite element method to study the process of esophageal emptying across the esophagogastric junction (EGJ). The model included an esophageal segment, an ellipsoid-shaped stomach, a bolus, and a simple model of the passive and active sphincteric functions of the lower esophageal sphincter (LES). We conducted three sets of case studies: (1) the effect of a non-relaxing LES; (2) the influence of the tissue anisotropy in the form of asymmetrical right- and left-sided compliance of the LES segment; and (3) the influence of LES and gastric wall stiffness on bulge formation of the distal esophageal wall...
April 11, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29627470/investigation-of-the-physical-properties-antioxidant-and-antimicrobial-activity-of-ternary-potato-starch-furcellaran-gelatin-films-incorporated-with-lavender-essential-oil
#10
Ewelina Jamróz, Lesław Juszczak, Mateusz Kucharek
Lavender essential oil (OEL) was added to starch, furcellaran and gelatin (S/F/G) films in concentrations of 2%, 4% and 6%. The films were examined in terms of physical properties (thickness, density, water solubility, water absorption and degree of swelling) and mechanical properties (tensile strength, elongation at break). The test results show that the film thickness increased upon addition of OEL. The solubility, water absorption and degree of swelling of the film decreased with increasing concentration of oils...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29625268/trunk-muscle-activation-patterns-during-walking-among-persons-with-lower-limb-loss-influences-of-walking-speed
#11
Courtney M Butowicz, Julian C Acasio, Christopher L Dearth, Brad D Hendershot
Persons with lower limb amputation (LLA) walk with altered trunk-pelvic motions. The underlying trunk muscle activation patterns associated with these motions may provide insight into neuromuscular control strategies post LLA and the increased incidence of low back pain (LBP). Eight males with unilateral LLA and ten able-bodied controls (CTR) walked over ground at 1.0 m/s, 1.3 m/s, 1.6 m/s, and self-selected speeds. Trunk muscle onsets/offsets were determined from electromyographic activity of bilateral thoracic (TES) and lumbar (LES) erector spinae...
March 26, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29617746/thoracoabdominal-pressure-gradient-and-gastroesophageal-reflux-insights-from-lung-transplant-candidates
#12
T Masuda, S K Mittal, B Kovacs, M Smith, R Walia, J Huang, R M Bremner
Advanced lung disease is associated with gastroesophageal reflux disease (GERD). The thoracoabdominal pressure gradient (TAPG) facilitates gastroesophageal reflux, but the effects of TAPG on gastroesophageal reflux in patients with pulmonary disease have not been well defined. Patients diagnosed with end-stage lung disease are expected to have the most extreme derangement in respiratory mechanics. The aim of this study is to explore the relationship between TAPG and reflux in lung transplant (LTx) candidates...
March 31, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29616748/electrocardiographic-t-wave-parameters-in-families-with-long-qt-syndrome
#13
Grażyna Markiewicz-Łoskot, Ewa Moric-Janiszewska, Bogusław Mazurek, Marianna Łoskot, Mariola Bartusek, Agnieszka Skierska, Lesław Szydłowski
BACKGROUND: T-wave parameters, especially the Tpeak-Tend interval (TpTe), reflect the total dispersion of repolarization, whose amplification may lead to the development of life-threatening ventricular arrhythmias observed in the long QT syndrome (LQTS). OBJECTIVES: The study attempted to evaluate QT, QTp (Q-Tpeak) and TpTe (Tpeak-Tend) intervals in unaffected and affected blood relatives of children with clinically confirmed LQTS as well as to determine whether the values of these repolarization parameters may be used in clinical practice...
March 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616636/h%C3%A3-patite-e-dans-les-camps
#14
P Bourée
No abstract text is available yet for this article.
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29616322/inter-individual-variability-in-the-production-of-flavan-3-ol-colonic-metabolites-preliminary-elucidation-of-urinary-metabotypes
#15
Pedro Mena, Iziar A Ludwig, Virginia B Tomatis, Animesh Acharjee, Luca Calani, Alice Rosi, Furio Brighenti, Sumantra Ray, Julian L Griffin, Les J Bluck, Daniele Del Rio
PURPOSE: There is much information on the bioavailability of (poly)phenolic compounds following acute intake of various foods. However, there are only limited data on the effects of repeated and combined exposure to specific (poly)phenol food sources and the inter-individual variability in their bioavailability. This study evaluated the combined urinary excretion of (poly)phenols from green tea and coffee following daily consumption by healthy subjects in free-living conditions. The inter-individual variability in the production of phenolic metabolites was also investigated...
April 3, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29609972/fixed-angle-plate-fixation-of-comminuted-patellar-fractures
#16
Tyler B Moore, Bharat R Sampathi, David P Zamorano, Martin C Tynan, John A Scolaro
INTRODUCTION: Comminuted patella fractures are uncommon and difficult fractures to manage. Multiple treatment modalities have been suggested, with little clinical data to support practice. Recent biomechanical and technical investigations have described successful plate fixation of comminuted patella fractures. The purpose of this study was to evaluate radiographic, clinical and functional outcome of comminuted patella fractures treated with a fixed angle locking plates. We believe stable fixation, which results in successful fracture union and functional recovery, can be achieved with this technique...
March 27, 2018: Injury
https://www.readbyqxmd.com/read/29609170/multisurface-modeling-of-ni-bioavailability-to-wheat-triticum-aestivum-l-in-various-soils
#17
Xiaopeng Zhao, Yang Jiang, Xueyuan Gu, Cheng Gu, J Anita Taylor, Les J Evans
Continual efforts have been made to determine a simple and universal method of estimating heavy metal phytoavailability in terrestrial systems. In the present study, a mechanism-based multi-surface model (MSM) was developed to predict the partition of Ni(II) in soil-solution phases and its bioaccumulation in wheat (Triticum aestivum L.) in 19 Chinese soils with a wide range of soil properties. MSM successfully predicted the Ni(II) dissolution in 0.01 M CaCl2 extracting solution (R2  = 0.875). The two-site model for clay fraction improved the prediction, particularly for alkaline soils, because of the additional consideration of edge sites...
March 30, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29608597/a-clinical-study-of-peroral-endoscopic-myotomy-reveals-that-impaired-lower-esophageal-sphincter-relaxation-in-achalasia-is-not-only-defined-by-high-resolution-manometry
#18
Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai
BACKGROUND AND AIM: Achalasia is an esophageal motility disorder characterized by impaired lower esophageal sphincter (LES) relaxation. On high-resolution manometry (HRM), impaired LES relaxation is defined by elevated integrated relaxation pressure (IRP). However, a new category of achalasia within the normal IRP range has been suggested. METHODS: HRM was performed using a Starlet device and an IRP threshold of 26 mmHg. Peroral endoscopic myotomy (POEM) was performed for cases of achalasia diagnosed using established methods...
2018: PloS One
https://www.readbyqxmd.com/read/29607397/initial-experience-with-a-novel-resection-and-plication-rap-method-for-acid-reflux-a-pilot-study
#19
Petros C Benias, Lionel D'Souza, Gloria Lan, Craig Gluckman, Sumant Inamdar, Arvind J Trindade, Larry S Miller, David L Carr-Locke
Background and study aims:  Current endoscopic therapies for gastroesophageal reflux disorder (GERD) are limited by technical complexity, and/or cost. We sought to evaluate the success of a novel resection and plication (RAP) anti-reflux procedure. Patients and methods:  RAP was performed on 10 patients with GERD refractory to proton pump inhibitor (PPI) therapy. RAP consists of semi-circumferential mucosectomy along with full-thickness plication of the lower esophageal sphincter (LES) and cardia...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29605981/axial-movements-and-length-changes-of-the-human-lower-esophageal-sphincter-during-respiration-and-distension-induced-secondary-peristalsis-using-functional-luminal-imaging-probe
#20
Donghua Liao, Christian Lottrup, Lotte Fynne, Barry P McMahon, Klaus Krogh, Asbjørn M Drewes, Jingbo Zhao, Hans Gregersen
Background/Aims: Efficient transport through the esophago-gastric junction (EGJ) requires synchronized circular and longitudinal muscle contraction of the esophagus including relaxation of the lower esophageal sphincter (LES). However, there is a scarcity of technology for measuring esophagus movements in the longitudinal (axial) direction. The aim of this study is to develop new analytical tools for dynamic evaluation of the length change and axial movement of the human LES based on the functional luminal imaging probe (FLIP) technology and to present normal signatures for the selected parameters...
April 30, 2018: Journal of Neurogastroenterology and Motility
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