keyword
MENU ▼
Read by QxMD icon Read
search

Subjective Cognitive Decline

keyword
https://www.readbyqxmd.com/read/29350336/brain-over-bladder-a-systematic-review-of-dual-cholinesterase-inhibitor-and-urinary-anticholinergic-use
#1
REVIEW
Laura K Triantafylidis, Jenna S Clemons, Emily P Peron, John Roefaro, Kristin M Zimmerman
BACKGROUND: Case reports have demonstrated that dual use of cholinesterase inhibitors (ChIs) and urinary anticholinergics (UAChs) in older adults may be associated with delusions, aggression, changes in cognition, and anxiety, which typically resolve on drug discontinuation. Despite opposing mechanisms of action, these drugs continue to be co-prescribed. OBJECTIVE: This systematic review evaluates cognitive and functional outcomes of dual use of ChIs and UAChs and describes its prevalence...
January 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29345732/near-visual-impairment-incidence-in-relation-to-diabetes-in-older-people-the-three-cities-study
#2
Marie Danet-Lamasou, Karine Pérès, Fanny Matharan, Claudine Berr, Isabelle Carrière, Christophe Tzourio, Cécile Delcourt, Isabelle Bourdel-Marchasson
OBJECTIVES: To characterize the relationship between diabetes mellitus (DM) and future risk of near vision impairment (VI) in a community-dwelling population of older people. DESIGN: Seven-year population-based longitudinal study. SETTING: Three-Cities Study, a French prospective study designed to assess the risk of cognitive and functional decline attributable to vascular factors. PARTICIPANTS: Community-dwelling individuals aged 65 and older (N = 8,412)...
January 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29344423/age-related-gray-and-white-matter-changes-in-normal-adult-brains
#3
Farnaz Farokhian, Chunlan Yang, Iman Beheshti, Hiroshi Matsuda, Shuicai Wu
Normal aging is associated with both structural changes in many brain regions and functional declines in several cognitive domains with advancing age. Advanced neuroimaging techniques enable explorative analyses of structural alterations that can be used as assessments of such age-related changes. Here we used voxel-based morphometry (VBM) to investigate regional and global brain volume differences among four groups of healthy adults from the IXI Dataset: older females (OF, mean age 68.35 yrs; n=69), older males (OM, 68...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29343737/moderate-decline-in-select-synaptic-markers-in-the-prefrontal-cortex-ba9-of-patients-with-alzheimer-s-disease-at-various-cognitive-stages
#4
Odile Poirel, Sébastien Mella, Catherine Videau, Lauriane Ramet, Maria Antonietta Davoli, Etienne Herzog, Pavel Katsel, Naguib Mechawar, Vahram Haroutunian, Jacques Epelbaum, Stéphanie Daumas, Salah El Mestikawy
Synaptic loss, plaques and neurofibrillary tangles are viewed as hallmarks of Alzheimer's disease (AD). This study investigated synaptic markers in neocortical Brodmann area 9 (BA9) samples from 171 subjects with and without AD at different levels of cognitive impairment. The expression levels of vesicular glutamate transporters (VGLUT1&2), glutamate uptake site (EAAT2), post-synaptic density protein of 95 kD (PSD95), vesicular GABA/glycine transporter (VIAAT), somatostatin (som), synaptophysin and choline acetyl transferase (ChAT) were evaluated...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343686/human-brain-patterns-underlying-vigilant-attention-impact-of-sleep-debt-circadian-phase-and-attentional-engagement
#5
M Maire, C F Reichert, V Gabel, A U Viola, C Phillips, C Berthomier, S Borgwardt, C Cajochen, C Schmidt
Sleepiness and cognitive function vary over the 24-h day due to circadian and sleep-wake-dependent mechanisms. However, the underlying cerebral hallmarks associated with these variations remain to be fully established. Using functional magnetic resonance imaging (fMRI), we investigated brain responses associated with circadian and homeostatic sleep-wake-driven dynamics of subjective sleepiness throughout day and night. Healthy volunteers regularly performed a psychomotor vigilance task (PVT) in the MR-scanner during a 40-h sleep deprivation (high sleep pressure) and a 40-h multiple nap protocol (low sleep pressure)...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343080/voices-from-australia-concerns-about-hiv-associated-neurocognitive-disorder
#6
Denise Cummins, Donna Waters, Christina Aggar, David Crawford, Judith Fethney, Catherine O'Connor
This study aimed to determine whether people living with HIV (PLHIV) are concerned about HIV associated neurocognitive disorder (HAND) and would find information and resources for HAND beneficial. An online survey focusing on the experience of HAND was distributed via the website of Positive Life New South Wales: a peak peer-support non-government organization in Australia. Of 126 respondents, 94 (74%) had heard of HAND, 52/94 (55%) had experienced concerns and of these, 48/52 (92%) felt anxiety about discussing the subject...
January 18, 2018: AIDS Care
https://www.readbyqxmd.com/read/29332050/supplemental-retinal-carotenoids-enhance-memory-in-healthy-individuals-with-low-levels-of-macular-pigment-in-a-randomized-double-blind-placebo-controlled-clinical-trial
#7
Rebecca Power, Robert F Coen, Stephen Beatty, Riona Mulcahy, Rachel Moran, Jim Stack, Alan N Howard, John M Nolan
BACKGROUND: There is a biologically plausible rationale whereby the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), which are collectively referred to as macular pigment (MP) in the central retina (macula), support the maintenance of cognition via their antioxidant and anti-inflammatory properties. OBJECTIVE: To investigate the impact of supplemental L, Z, and MZ on memory, executive function, and verbal fluency among healthy individuals with low MP levels...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29330990/association-of-quality-of-sleep-with-cognitive-decline-among-the-patients-of-chronic-kidney-disease-undergoing-haemodialysis
#8
Usama Bin Zubair, Batool Butt
BACKGROUND: This study was conducted to determine the association between the subjective quality of sleep and cognitive decline among the patients of chronic kidney disease (CKD) undergoing haemodialysis. METHODS: In this cross-sectional study 106 patients of chronic kidney disease (CKD) undergoing haemodialysis at a tertiary care hospital in Rawalpindi, Pakistan were included in the final analysis. Cognitive decline was measured by British Columbia Cognitive Complaints Inventory (BC-CCI)...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29326033/the-contribution-of-gender-differences-in-motor-behavioral-and-cognitive-features-to-functional-capacity-independence-and-quality-of-life-in-patients-with-huntington-s-disease
#9
Daniel Zielonka, Michał Ren, Giuseppe De Michele, Raymund A C Roos, Ferdinando Squitieri, Anna Rita Bentivoglio, Jerzy T Marcinkowski, G Bernhard Landwehrmeyer
INTRODUCTION: Huntington's disease (HD) is a neurodegenerative autosomal dominant disorder affecting patients' motor, behavioral and cognitive domains leading to total dependency for activities of daily life. This study compares whether gender differences in motor, cognitive and behavioral symptoms affect function and how functional impairment affects quality of life (QoL). METHODS: We recruited 2191 subjects from the REGISTRY data base that provides personal data, HD age of onset, visit date, CAG mutation size, UHDRS and TFC scores from at least one visit...
January 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29325011/cognitive-complaints-in-memory-clinic-patients-and-in-depressive-patients-an-interpretative-phenomenological-analysis
#10
Lisa Miebach, Steffen Wolfsgruber, Ingo Frommann, Klaus Fließbach, Frank Jessen, Rachel Buckley, Michael Wagner
Background and Objectives: Cognitive complaints are discussed as early signs of Alzheimer's disease (AD). However, they are also very common in cognitively normal older adults and in patients with depression. Qualitative, interview-based approaches might be useful to identify those features of cognitive complaints specific for the experiences of cognitive decline in preclinical or prodromal AD versus those complaints typically reported by depressed patients. Research Design and Methods: A semi-structured interview was administered to 21 cognitively normal older adults (HC), 18 nondemented memory clinic patients (MC), and 11 patients with a major depression (MD), all above 55 years...
January 8, 2018: Gerontologist
https://www.readbyqxmd.com/read/29324915/self-report-instruments-of-cognitive-failures-as-screening-tools-for-subjective-cognitive-impairment-in-older-adults
#11
Vasileios Papaliagkas, G Papantoniou, Magda Tsolaki, Despina Moraitou
BACKGROUND: The term "Subjective Cognitive Impairment (SCI)" is the most widely accepted term for cognitive complaints of otherwise apparently healthy older adults. It is presently clear that SCI might be a risk factor for the development of Mild Cognitive Impairment and dementia. As regards SCI measurement and potential diagnosis, several studies showed that SCI is a condition in which people score in the normal range on common tests but believe they experience cognitive decline. Hence, to assess the characteristic of the SCI subtle cognitive decline, self-report measures were developed to estimate "self-experience" of minimal decline in cognition seem the most appropriate tools...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29322488/difficulties-with-fine-motor-skills-and-cognitive-impairment-in-an-elderly-population-the-progetto-veneto-anziani
#12
Chiara Curreri, Caterina Trevisan, Pamela Carrer, Silvia Facchini, Valter Giantin, Stefania Maggi, Marianna Noale, Marina De Rui, Egle Perissinotto, Sabina Zambon, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: To investigate dysfunction in fine motor skills in a cohort of older Italian adults, identifying their prevalence and usefulness as indicators and predictors of cognitive impairment. DESIGN: Population-based longitudinal study with mean follow-up of 4.4 years. SETTING: Community. PARTICIPANTS: Older men and women enrolled in the Progetto Veneto Anziani (Pro.V.A.) (N = 2,361); 1,243 subjects who were cognitively intact at baseline were selected for longitudinal analyses...
January 11, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29317593/loneliness-5-years-ante-mortem-is-associated-with-disease-related-differential-gene-expression-in-postmortem-dorsolateral-prefrontal-cortex
#13
Turhan Canli, Lei Yu, Xiaoqing Yu, Hongyu Zhao, Debra Fleischman, Robert S Wilson, Philip L De Jager, David A Bennett
Subjective social isolation, loneliness, is associated with poor mental and physical health, but the underlying molecular mechanisms are poorly understood. Here we analyzed loneliness data collected on average 5 years ante-mortem and RNA gene expression at death in postmortem dorsolateral prefrontal cortex (DLPFC) from 181 participants in the Rush Memory and Aging Project (MAP), a longitudinal, prospective cohort study of common chronic conditions of aging. Our analytic protocol controlled for biographical variables (age, sex, education), psychological and health variables (depressive symptoms, interval between assessment and autopsy, slope of cognitive decline, AD pathology, presence of infarcts) and RNA integrity...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29316965/decreased-microglial-activation-through-gut-brain-axis-by-prebiotics-probiotics-or-synbiotics-effectively-restored-cognitive-function-in-obese-insulin-resistant-rats
#14
Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C Chattipakorn
BACKGROUND: Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics and probiotics improved obese-insulin resistance. However, the effects of prebiotics, probiotics, and synbiotics on cognition and microglial activity in an obese-insulin resistant condition have not yet been investigated. We aimed to evaluate the effect of prebiotic (Xyloolidosaccharide), probiotic (Lactobacillus paracasei HII01), or synbiotics in male obese-insulin resistant rats induced by a HFD...
January 9, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29315079/safety-and-tolerability-of-spermidine-supplementation-in-mice-and-older-adults-with-subjective-cognitive-decline
#15
Claudia Schwarz, Slaven Stekovic, Miranka Wirth, Gloria Benson, Philipp Royer, Stephan J Sigrist, Thomas Pieber, Christopher Dammbrueck, Christoph Magnes, Tobias Eisenberg, Tobias Pendl, Jens Bohlken, Theresa Köbe, Frank Madeo, Agnes Flöel
Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models. The present translational study aimed to determine safety and tolerability of a wheat germ extract containing enhanced spermidine concentrations. In a preclinical toxicity study, supplementation of spermidine using this extract did not result in morbidities or changes in behavior in BALBc/Rj mice during the 28-days repeated-dose tolerance study. Post mortem examination of the mice organs showed no increase in tumorigenic and fibrotic events...
January 8, 2018: Aging
https://www.readbyqxmd.com/read/29305751/volumetric-comparison-of-hippocampal-subfields-extracted-from-4-minute-accelerated-vs-8-minute-high-resolution-t2-weighted-3t-mri-scans
#16
Shan Cong, Shannon L Risacher, John D West, Yu-Chien Wu, Liana G Apostolova, Eileen Tallman, Maher Rizkalla, Paul Salama, Andrew J Saykin, Li Shen
The hippocampus has been widely studied using neuroimaging, as it plays an important role in memory and learning. However, hippocampal subfield information is difficult to capture by standard magnetic resonance imaging (MRI) techniques. To facilitate morphometric study of hippocampal subfields, ADNI introduced a high resolution (0.4 mm in plane) T2-weighted turbo spin-echo sequence that requires 8 min. With acceleration, the protocol can be acquired in 4 min. We performed a comparative study of hippocampal subfield volumes using standard and accelerated protocols on a Siemens Prisma 3T MRI in an independent sample of older adults that included 10 cognitively normal controls, 9 individuals with subjective cognitive decline, 10 with mild cognitive impairment, and 6 with a clinical diagnosis of Alzheimer's disease (AD)...
January 5, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29304748/revisiting-the-link-between-cognitive-decline-and-masticatory-dysfunction
#17
Chia-Shu Lin
Age-related decline in cognitive functions and dementia are major challenges in geriatric healthcare. Accumulating evidence from clinical, epidemiological and animal research suggests that tooth loss may be a risk factor for the decline of cognitive functions. This issue highlights the role of the brain-stomatognathic axis in geriatric medicine. Whether input from the stomatognathic apparatus can affect the brain remains an open debate. By revisiting the evidence published in the past five years, we argue that the hypothesis regarding the association between cognitive decline and masticatory dysfunction should be carefully interpreted...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29303427/the-association-of-total-cholesterol-with-processing-speed-is-moderated-by-age-in-mid-to-late-age-healthy-adults
#18
Odelia Elkana, Vitali Dayman, Motty Franko, Ariel Israel, Ramit Ravona Springer, Shlomo Segev, Michal Schnaider Beeri
OBJECTIVES: To investigate the nature of the association of normal levels of total cholesterol with cognitive function and the contribution of age to this association. METHODS: A sample of 61 senior executives, who were summoned for an annual medical examination with approximately four measurements of total cholesterol during 4 years, were examined with a computerized cognitive battery assessing mental processing speed as a sensitive measure of cognitive decline...
January 5, 2018: Experimental Aging Research
https://www.readbyqxmd.com/read/29301654/the-additive-effect-of-aging-on-sepsis-induced-cognitive-impairment-and-neuroinflammation
#19
Rodrigo Olivieri, Monique Michels, Bruna Pescador, Pricila Ávila, Mariane Abatti, Luana Cucker, Henrique Burger, Diogo Dominguini, João Quevedo, Felipe Dal-Pizzol
Systemic inflammation is emerging as a significant driver of cognitive decline in the aged and vulnerable brain. In sepsis survivors animals low-grade brain inflammation occurs, suggesting that sepsis is able to induce in microglia a primed-like state. The purpose of this study is to analyze the role of sepsis-induced brain inflammation in the progression of the physiological process of brain aging. Wistar rats 2month-old were subjected to sepsis and 60 and 90days after were submitted to the new object recognition test and brain was removed to the determination of cytokines, myeloperoxidase (MPO) activity, amyloid-beta peptide (Aβ) and immunohistochemistry markers of microglial activation...
January 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29289386/mortality-risk-factors-in-elderly-patients-in-intensive-care-without-limitation-of-therapeutic-effort
#20
S E Giannasi, M S Venuti, A D Midley, N Roux, C Kecskes, E San Román
OUTCOME: To determine mortality prognostic factors in elderly patients who are admitted to intensive care units (ICUs) due to acute critical illness. DESIGN: A prospective cohort study was carried out. SETTING: A polyvalent Intensive Care Unit at a University Hospital in Argentina. PATIENTS OR PARTICIPANTS: We included 249 patients over 65years of age who were consecutively admitted to the ICU and required mechanical ventilation for more than 48hours, between January 2011 and December 2012...
December 27, 2017: Medicina Intensiva
keyword
keyword
92172
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"