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Subjective Cognitive Decline

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https://www.readbyqxmd.com/read/28226792/steady-state-visual-evoked-potential-based-brain-computer-interface-for-cognitive-assessment
#1
Nicolai Westergren, Rasmus L Bendtsen, Troels W Kjaer, Carsten E Thomsen, S Puthusserypady, Helge B D Sorensen, Nicolai Westergren, Rasmus L Bendtsen, Troels W Kjaer, Carsten E Thomsen, S Puthusserypady, Helge B D Sorensen, Troels W Kjaer, Nicolai Westergren, Carsten E Thomsen, Helge B D Sorensen, Rasmus L Bendtsen, S Puthusserypady
Cognitive assessment is of growing importance, with the general population getting older and a rapidly growing incidence of dementia, which is a major public health issue. Treatment of dementia must, to be most effective, start early in the disease process. Thus, early detection of cognitive decline is important. Cognitive decline may be detected using fully-automated computerized assessment. Such systems will provide inexpensive and widely available screenings of cognitive ability. The aim of this pilot study is to develop a real time steady state visual evoked potential (SSVEP) based brain-computer interface (BCI) for neurological cognitive assessment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224692/renal-function-affects-hippocampal-volume-and-cognition-the-role-of-vascular-burden-and-amyloid-deposition
#2
Hoyoung An, Booyeol Choi, Sang Joon Son, Eun Young Cho, Seon-Ok Kim, Sooyun Cho, Duk-Hee Kang, Chul Lee, Seong Yoon Kim
AIM: We determined if differences in renal function, even within normal levels, influenced hippocampal volume (HCV) and cognition. METHODS: Cognitively normal (CN) and mild cognitive impairment (MCI) subjects with eGFR ≥ 60 ml/min/1.73m(2) were selected from the ADNI database (N = 1,269) and divided into three groups (eGFR 60-75, 75-90 and ≥90). Associations between eGFR, HCV and cognition scores were examined using regression methods, and random-coefficient models...
February 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28223932/cerebrospinal-fluid-levels-of-amyloid-beta-1-43-mirror-1-42-in-relation-to-imaging-biomarkers-of-alzheimer-s-disease
#3
Ina S Almdahl, Camilla Lauridsen, Per Selnes, Lisa F Kalheim, Christopher Coello, Beata Gajdzik, Ina Møller, Marianne Wettergreen, Ramune Grambaite, Atle Bjørnerud, Geir Bråthen, Sigrid B Sando, Linda R White, Tormod Fladby
Introduction: Amyloid beta 1-43 (Aβ43), with its additional C-terminal threonine residue, is hypothesized to play a role in early Alzheimer's disease pathology possibly different from that of amyloid beta 1-42 (Aβ42). Cerebrospinal fluid (CSF) Aβ43 has been suggested as a potential novel biomarker for predicting conversion from mild cognitive impairment (MCI) to dementia in Alzheimer's disease. However, the relationship between CSF Aβ43 and established imaging biomarkers of Alzheimer's disease has never been assessed...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28222503/selenium-levels-in-serum-red-blood-cells-and-cerebrospinal-fluid-of-alzheimer-s-disease-patients-a-report-from-the-australian-imaging-biomarker-lifestyle-flagship-study-of-ageing-aibl
#4
Bárbara R Cardoso, Dominic J Hare, Ashley I Bush, Qiao-Xin Li, Christopher J Fowler, Colin L Masters, Ralph N Martins, Katherine Ganio, Amber Lothian, Soumya Mukherjee, Eugene A Kapp, Blaine R Roberts
Selenium (Se) protects cells against oxidative stress damage through a range of bioactive selenoproteins. Increased oxidative stress is a prominent feature of Alzheimer's disease (AD), and previous studies have shown that Se deficiency is associated with age-related cognitive decline. In this study, we assessed Se status in different biofluids from a subgroup of participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. As Se in humans can either be an active component of selenoproteins or inactive via non-specific incorporation into other proteins, we used both size exclusion chromatography-inductively coupled plasma-mass spectrometry (SEC-ICP-MS) and tandem mass spectrometry to characterize selenoproteins in serum...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222300/free-and-cued-selective-reminding-test-accuracy-for-alzheimer-s-and-neurodegenerative-disease-differential-diagnosis-a-large-scale-biomarker-characterized-monocenter-cohort-study-clinad
#5
Marc Teichmann, Stéphane Epelbaum, Dalila Samri, Marcel Levy Nogueira, Agnès Michon, Harald Hampel, Foudil Lamari, Bruno Dubois
INTRODUCTION: The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? METHODS: We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts, blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, "subjective cognitive decline," or depression...
February 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28217868/an-anti-nicotinic-cognitive-challenge-model-using-mecamylamine-in-comparison-with-the-anti-muscarinic-cognitive-challenge-using-scopolamine
#6
A C Baakman, R Alvarez-Jimenez, R Rissmann, E S Klaassen, J Stevens, S C Goulooze, J Burger, E L Swart, J M A van Gerven, G J Groeneveld
INTRODUCTION: The muscarinic acetylcholine receptor antagonist scopolamine is often used for proof-of-pharmacology studies with pro-cognitive compounds. From a pharmacological point of view, it would seem more rational to use a nicotinic rather than a muscarinic anticholinergic challenge to prove pharmacology of a nicotinic acetylcholine receptor agonist. This study aims to characterize a nicotinic anticholinergic challenge model using mecamylamine and to compare it to the scopolamine model...
February 20, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28213293/relations-between-personality-changes-and-cerebrospinal-fluid-biomarkers-of-alzheimer-s-disease-pathology
#7
D Tautvydaitė, J P Antonietti, H Henry, A von Gunten, J Popp
Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. With this study we aimed to describe the relationship between personality changes and cerebrospinal fluid (CSF) markers of AD pathology at early clinical stages of the disease. One hundred and ten subjects, of whom 66 cognitively impaired patients (57 with mild cognitive impairment (MCI), and 9 with mild dementia) and 44 healthy controls, had neuropsychological examination as well as lumbar puncture to determine concentrations of CSF biomarkers of AD pathology (amyloid beta1-42 (Aβ1-42), phosphorylated tau (ptau-181), and total-tau (tau))...
February 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28209926/characterization-of-the-influence-of-age-on-gabaa-and-glutamatergic-mediated-functions-in-the-dorsolateral-prefrontal-cortex-using-paired-pulse-tms-eeg
#8
Yoshihiro Noda, Reza Zomorrodi, Robin F H Cash, Mera S Barr, Faranak Farzan, Tarek K Rajji, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of these substances, direct neurophysiological data investigating the effect of aging in the DLPFC in human subjects is lacking. The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo...
February 16, 2017: Aging
https://www.readbyqxmd.com/read/28202945/left-ventricular-hypertrophy-in-association-with-cognitive-impairment-a-systematic-review-and-meta-analysis
#9
Marios K Georgakis, Andreas Synetos, Constantinos Mihas, Maria A Karalexi, Dimitrios Tousoulis, Sudha Seshadri, Eleni Th Petridou
Left ventricular hypertrophy (LVH) is a marker of prolonged exposure to high blood pressure and a predictor of cardiovascular disease risk. The objective of the current study was to investigate its association with cognitive function. Following standard guidelines, pairs of independent reviewers screened 2359 articles to search for studies that addressed the research question, extracted data and evaluated the quality of the studies using the Newcastle-Ottawa scale; authors were contacted for additional data...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28196313/executive-functioning-at-baseline-prospectively-predicts-depression-treatment-response
#10
Erica L Dawson, Angela F Caveney, Kortni K Meyers, Sara L Weisenbach, Bruno Giordani, Erich T Avery, Michael-Paul Schallmo, Armita Bahadori, Linas A Bieliauskas, Matthew Mordhorst, Sheila M Marcus, Kevin Kerber, Jon-Kar Zubieta, Scott A Langenecker
Objective: Existing cognitive and clinical predictors of treatment response to date are not of sufficient strength to meaningfully impact treatment decision making and are not readily employed in clinical settings. This study investigated whether clinical and cognitive markers used in a tertiary care clinic could predict response to usual treatment over a period of 4 to 6 months in a sample of 75 depressed adults. Methods: Patients (N = 384) were sequentially tested in 2 half-day clinics as part of a quality improvement project at an outpatient tertiary care center between August 2003 and September 2007; additional subjects evaluated in the clinic between 2007 and 2009 were also included...
February 9, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28193256/unbiased-estimates-of-cerebrospinal-fluid-%C3%AE-amyloid-1-42-cutoffs-in-a-large-memory-clinic-population
#11
Daniela Bertens, Betty M Tijms, Philip Scheltens, Charlotte E Teunissen, Pieter Jelle Visser
BACKGROUND: We sought to define a cutoff for β-amyloid 1-42 in cerebrospinal fluid (CSF), a key marker for Alzheimer's disease (AD), with data-driven Gaussian mixture modeling in a memory clinic population. METHODS: We performed a combined cross-sectional and prospective cohort study. We selected 2462 subjects with subjective cognitive decline, mild cognitive impairment, AD-type dementia, and dementia other than AD from the Amsterdam Dementia Cohort. We defined CSF β-amyloid 1-42 cutoffs by data-driven Gaussian mixture modeling in the total population and in subgroups based on clinical diagnosis, age, and apolipoprotein E (APOE) genotype...
February 14, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28185224/white-matter-microstructure-and-subcortical-gray-matter-structure-volumes-in-aspartylglucosaminuria-a-5-year-follow-up-brain-mri-study-of-an-adolescent-with-aspartylglucosaminuria-and-his-healthy-twin-brother
#12
Anna Tokola, Nina Brandstack, Antti Hakkarainen, Eero Salli, Laura Åberg, Taina Autti
OBJECTIVE: Aspartylglucosaminuria is an inherited, lysosomal storage disease causing progressive decline in cognitive and motor functions. The aim of this study was to evaluate volumes of subcortical gray matter structures and white matter microstructure in aspartylglucosaminuria in adolescence in a longitudinal study for the first time. METHODS: A boy with aspartylglucosaminuria and his healthy twin brother were imaged twice with a 3.0 T MRI scanner at the ages of 10 and 15 years...
February 10, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28184209/theory-of-mind-is-impaired-in-mild-to-moderate-huntington-s-disease-independently-from-global-cognitive-functioning
#13
Giovanna Lagravinese, Laura Avanzino, Alessia Raffo De Ferrari, Roberta Marchese, Carlo Serrati, Paola Mandich, Giovanni Abbruzzese, Elisa Pelosin
Affective "Theory of Mind" (ToM) is the specific ability to represent own and others' emotional states and feelings. Previous studies examined affective ToM ability in patients with Huntington's disease (HD), using the "Reading the Mind in the Eyes test" (RMET). Results were consistent in showing difficulties in inferring complex mental states from photographs of people even in the early stage of HD. However, there has been no agreement as to whether or not cognitive impairments in HD population might have contributed to poor performance on the RMET test...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28181457/cognitive-and-affective-functions-associated-with-insomnia-a-population-based-study
#14
Nozomi Hishikawa, Yusuke Fukui, Kota Sato, Yasuyuki Ohta, Toru Yamashita, Koji Abe
OBJECTIVES: The number of patients with insomnia is rapidly increasing as society ages. The influence of insomnia on cognitive, affective, and activities of daily living (ADL) functions has not been fully studied. METHODS: Participants were 142 residents of a local super-aged community who underwent health check-ups provided by the local government. Participants completed cognitive, affective and ADL function tests including the MMSE. We divided participants into two subgroups based on Athens Insomnia Scale (AIS) scores (AIS ≤3 and AIS ≥4) and compared cognitive, affective, and ADL functions by sex and age...
February 9, 2017: Neurological Research
https://www.readbyqxmd.com/read/28177065/gait-speed-and-grip-strength-reflect-cognitive-impairment-and-are-modestly-related-to-incident-cognitive-decline-in-memory-clinic-patients-with-subjective-cognitive-decline-and-mild-cognitive-impairment-findings-from-the-4c-study
#15
Astrid M Hooghiemstra, Inez H G B Ramakers, Nicole Sistermans, Yolande A L Pijnenburg, Pauline Aalten, Renske E G Hamel, René J F Melis, Frans R J Verhey, Marcel G M Olde Rikkert, Philip Scheltens, Wiesje M van der Flier
No abstract text is available yet for this article.
February 8, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28170189/mesenchymal-stem-cells-yield-transient-improvements-in-motor-function-in-an-infant-rhesus-macaque-with-severe-early-onset-krabbe-disease
#16
Irina A Isakova, Kate C Baker, Jason Dufour, Donald G Phinney
Krabbe disease, or globoid cell leukodystrophy, is a rare disorder caused by deficient galactosylceramidase activity and loss of myelin-forming oligodendrocytes, resulting in progressive demyelination and severely impaired motor function. Disease symptoms in humans appear within 3-6 months of age (early infantile) and manifest as marked irritability, spasticity, and seizures. The disease is often fatal by the second year of life, with few effective treatment options. Herein we evaluated the therapeutic potential of mesenchymal stem cells (MSCs) administered intracranially to a 1-month-old rhesus macaque diagnosed with severe early-onset Krabbe disease that displayed neurologic and behavioral symptoms similar to those of human patients...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28169310/tai-chi-chuan-and-baduanjin-practice-modulates-functional-connectivity-of-the-cognitive-control-network-in-older-adults
#17
Jing Tao, Xiangli Chen, Natalia Egorova, Jiao Liu, Xiehua Xue, Qin Wang, Guohua Zheng, Moyi Li, Wenjun Hong, Sharon Sun, Lidian Chen, Jian Kong
Cognitive impairment is one of the most common problem saffecting older adults. In this study, we investigated whether Tai Chi Chuan and Baduanjin practice can modulate mental control functionand the resting state functional connectivity (rsFC) of the cognitive control network in older adults. Participants in the two exercise groups practiced either Tai Chi Chuan or Baduanjin for 12 weeks, and those in the control group received basic health education. Memory tests and fMRI scans were conducted at baseline and at the end of the study...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28168099/gait-disorder-as-a-predictor-of-spatial-learning-and-memory-impairment-in-aged-mice
#18
Xin Wang, Qing M Wang, Zhaoxiang Meng, Zhenglu Yin, Xun Luo, Duonan Yu
OBJECTIVE: To investigate whether gait dysfunction is a predictor of severe spatial learning and memory impairment in aged mice. METHODS: A total of 100 12-month-old male mice that had no obvious abnormal motor ability and whose Morris water maze performances were not significantly different from those of two-month-old male mice were selected for the study. The selected aged mice were then divided into abnormal or normal gait groups according to the results from the quantitative gait assessment...
2017: PeerJ
https://www.readbyqxmd.com/read/28164725/applying-psycholinguistic-evidence-to-the-construction-of-a-new-test-of-verbal-memory-in-late-life-cognitive-decline
#19
Johannes Baltasar Hessler, David Brieber, Johanna Egle, Georg Mandler, Thomas Jahn
The construction of the German Auditory Wordlist Learning Test (AWLT) for the assessment of verbal memory in late-life cognitive decline was guided by psycholinguistic evidence, which indicates that a word's linguistic characteristics influence its probability of being learned and recalled. The AWLT includes four trials of learning, short and long delayed free recall, and a recognition task. Its words were selected with taking into account their semantic content, orthographic length, frequency in the language, and orthographic neighborhood size (the number of words derived by adding, subtracting, or replacing a single letter at a time)...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/28163503/pattern-reversal-visual-evoked-potential-and-cognitive-functions-in-subclinical-hypothyroid-subjects
#20
Pooja Jaiswal, Yogesh Saxena, Rani Gupta, Rajeev Mohan Kaushik
BACKGROUND: Central nervous system (CNS) involvement is insidious and may occur early in subclinical hypothyroid (SCH) state which can be picked up by electrophysiological study. This study aims to record visual evoked potential (VEP), event-related latency and cognitive functions, and find their association with the levels of serum thyroid-stimulating hormone (TSH) in patients with SCH. MATERIALS AND METHODS: In this cross-sectional study, 36 adult SCH patients and an equal number of age- and sex-matched euthyroid controls were included...
December 2016: Journal of Neurosciences in Rural Practice
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