Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Imke Janssen, Lynda H Powell, Sheila A Dugan, Carol A Derby, Howard M Kravitz
BACKGROUND: Cognitive decline may progress for decades before dementia onset. Better cardiovascular health (CVH) has been related to less cognitive decline, but it is unclear whether this begins early, for all racial subgroups, and all domains of cognitive function. The purpose of this study was to determine the impact of CVH on decline in the 2 domains of cognition that decline first in White and Black women at midlife. METHODS AND RESULTS: Subjects were 363 Black and 402 White women, similar in baseline age (mean±SD, 46...
April 24, 2024: Journal of the American Heart Association
#2
JOURNAL ARTICLE
Assunta Ingannato, Silvia Bagnoli, Salvatore Mazzeo, Giulia Giacomucci, Valentina Bessi, Camilla Ferrari, Sandro Sorbi, Benedetta Nacmias
BACKGROUND: Plasma biomarkers are preferable to invasive and expensive diagnostic tools, such as neuroimaging and lumbar puncture that are gold standard in the clinical management of Alzheimer's Disease (AD). Here, we investigated plasma Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light Chain (NfL) and Phosphorylated-tau-181 (pTau 181) in AD and in its early stages: Subjective cognitive decline (SCD) and Mild cognitive impairment (MCI). MATERIAL AND METHODS: This study included 152 patients (42 SCD, 74 MCI and 36 AD)...
2024: Frontiers in Endocrinology
#3
JOURNAL ARTICLE
Hannah Baumeister, Jacob W Vogel, Philip S Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M Gellersen, Renat Yakupov, Matthias C Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka D Freiesleben, Lukas Preis, Luisa-Sophie Schneider, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Ina R Vogt, Claudia Bartels, Björn H Schott, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Doreen Goerss, Matthias H Munk, Stefan Hetzer, Peter Dechent, Michael Ewers, Klaus Scheffler, Anika Wuestefeld, Olof Strandberg, Danielle van Westen, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Annika Spottke, Christoph Laske, Stefan Teipel, Robert Perneczky, Katharina Buerger, Anja Schneider, Josef Priller, Oliver Peters, Alfredo Ramirez, Jens Wiltfang, Michael T Heneka, Michael Wagner, Emrah Düzel, Frank Jessen, Oskar Hansson, David Berron
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± SD age = 70...
April 24, 2024: Brain
#4
RANDOMIZED CONTROLLED TRIAL
Cristiane Peixoto, Maria Niures Pimentel Dos Santos Matioli, Satiko Andrezza Ferreira Takano, Maurício Silva Teixeira, Carlos Eduardo Borges Passos Neto, Sonia Maria Dozzi Brucki
BACKGROUND: Population aging and the consequences of social distancing after the COVID-19 pandemic make it relevant to investigate the feasibility of remote interventions and their potential effects on averting functional decline. OBJECTIVE: (1) To investigate the feasibility, safety, and adherence of a remote protocol involving physical and cognitive exercises for older women with normal cognition; (2) to examine its effects on cognitive and well-being variables...
April 2024: Arquivos de Neuro-psiquiatria
#5
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#6
JOURNAL ARTICLE
Joël Macoir, Pascale Tremblay, Stéphanie Beaudoin, Mathias Parent, Carol Hudon
Subjective cognitive decline (SCD) may serve as an early indicator of Alzheimer's disease (AD). However, accurately quantifying cognitive impairment in SCD is challenging, mainly because existing assessment tools lack sensitivity. This study examined how tasks specifically designed to assess knowledge of famous people, could potentially aid in identifying cognitive impairment in SCD. A total of 60 adults with SCD and 60 healthy controls (HCs) aged 50 to 82 years performed a famous people verbal fluency task and a famous people naming task...
April 22, 2024: Applied Neuropsychology. Adult
#7
JOURNAL ARTICLE
Jingnan Sun, Zengmai Xie, Yike Sun, Anruo Shen, Renren Li, Xiao Yuan, Bai Lu, Yunxia Li
Alzheimer's disease (AD) constitutes a neurodegenerative disorder marked by a progressive decline in cognitive function and memory capacity. The accurate diagnosis of this condition predominantly relies on cerebrospinal fluid (CSF) markers, notwithstanding the associated burdens of pain and substantial financial costs endured by patients. This study encompasses subjects exhibiting varying degrees of cognitive impairment, encompassing individuals with subjective cognitive decline, mild cognitive impairment, and dementia, constituting a total sample size of 82 participants...
May 2024: MedComm
#8
JOURNAL ARTICLE
Qian Liu, Fang Wang, Lixia Tan, Li Liu, Xiuying Hu
INTRODUCTION: Subjective cognitive decline means a decline in the subjective perception of self-cognitive function, which is likely to evolve into mild cognitive impairment and dementia. The number of elderly with subjective cognitive decline has increased, bringing huge burdens and challenges to caregivers and society. With the increase in research on art therapies, some of them have gradually been proven to be effective for cognitive function. Therefore, this study aims to summarise the evidence and identify the best art therapy for elderly with subjective cognitive decline...
April 19, 2024: BMJ Open
#9
JOURNAL ARTICLE
Yifei Zhang, Zehan Zhang, Qingqian Yu, Bijuan Lan, Qinghuan Shi, Ruting Li, Ziheng Jiao, Weiyue Zhang, Feng Li
Central fatigue is a common pathological state characterized by psychological loss of drive, lack of appetite, drowsiness, and decreased psychic alertness. The mechanism underlying central fatigue is still unclear, and there is no widely accepted successful animal model that fully represents human characteristics. We aimed to construct a more clinically relevant and comprehensive animal model of central fatigue. In this study, we utilized the Modified Multiple Platform Method (MMPM) combined with alternate-day fasting (ADF) to create the animal model...
April 18, 2024: Brain Research Bulletin
#10
JOURNAL ARTICLE
Marco Ceccanti, Laura Libonati, Federica Moret, Edoardo D'Andrea, Maria Cristina Gori, Francesco Saverio Bersani, Maurizio Inghilleri, Chiara Cambieri
OBJECTIVE: The aim of our study was to measure the ability of ALS patients to process dynamic facial expressions as compared to a control group of healthy subjects and to correlate this ability in ALS patients with neuropsychological, clinical and neurological measures of the disease. METHODS: Sixty-three ALS patients and 47 healthy controls were recruited. All the ALS patients also underwent i) the Geneva Emotion Recognition Test (GERT) in which ten actors express 14 types of dynamic emotions in brief video clips with audio, ii) the Edimburgh Cognitive and Behavioral ALS Screen (ECAS) test; iii) the ALS Functional Rating Scale Revised (ALSFRS-R) and iv) the Medical Research Council (MRC) for the evaluation of muscle strength...
April 16, 2024: Journal of the Neurological Sciences
#11
JOURNAL ARTICLE
Han Soo Yoo, Han-Kyeol Kim, Jae-Hoon Lee, Joong-Hyun Chun, Hye Sun Lee, Michel J Grothe, Stefan Teipel, Enrica Cavedo, Andrea Vergallo, Harald Hampel, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyoo
BACKGROUND: Degeneration of cholinergic basal forebrain (BF) neurons characterizes Alzheimer's disease (AD). However, what role the BF plays in the dynamics of AD pathophysiology has not been investigated precisely. OBJECTIVE: To investigate the baseline and longitudinal roles of BF along with core neuropathologies in AD. METHODS: In this retrospective cohort study, we enrolled 113 subjects (38 amyloid [Aβ]-negative cognitively unimpaired, 6 Aβ-positive cognitively unimpaired, 39 with prodromal AD, and 30 with AD dementia) who performed brain MRI for BF volume and cortical thickness, 18F-florbetaben PET for Aβ, 18F-flortaucipir PET for tau, and detailed cognitive testing longitudinally...
April 16, 2024: Journal of Alzheimer's Disease: JAD
#12
JOURNAL ARTICLE
Martina Montalti, Giovanni Mirabella
INTRODUCTION: The widespread use of surgical masks during the COVID-19 pandemic has posed challenges in interpreting facial emotions. As the mouth is known to play a crucial role in decoding emotional expressions, its covering is likely to affect this process. Recent evidence suggests that facial expressions impact behavioral responses only when their emotional content is relevant to subjects' goals. Thus, this study investigates whether and how masked emotional faces alter such a phenomenon...
2024: Frontiers in Psychology
#13
REVIEW
Ignacio Negrón-Oyarzo, Tatiana Dib, Lorena Chacana-Véliz, Nélida López-Quilodrán, Jocelyn Urrutia-Piñones
Cognitive control of behavior is crucial for well-being, as allows subject to adapt to changing environments in a goal-directed way. Changes in cognitive control of behavior is observed during cognitive decline in elderly and in pathological mental conditions. Therefore, the recovery of cognitive control may provide a reliable preventive and therapeutic strategy. However, its neural basis is not completely understood. Cognitive control is supported by the prefrontal cortex, structure that integrates relevant information for the appropriate organization of behavior...
2024: Frontiers in Neural Circuits
#14
JOURNAL ARTICLE
Cristina Jaén, Christopher Maute, Scott Mackin, Monica R Camacho, Diana Truran, Rachel Nosheny, Michael W Weiner, Pamela Dalton
BACKGROUND: Early identification of deficits in our ability to perceive odors is important as many normal (i.e., aging) and pathological (i.e., sinusitis, viral, neurodegeneration) processes can result in diminished olfactory function. To realistically enable population-level measurements of olfaction, validated olfaction tests must be capable of being administered outside the research laboratory and clinical setting. AIM: The purpose of this study was to determine the feasibility of remotely testing olfactory performance using a test that was developed with funding from the National Institutes of Health as part of a ready-to-use, non-proprietary set of measurements useful for epidemiologic studies (NIH Toolbox Odor ID Test)...
2024: PloS One
#15
JOURNAL ARTICLE
Elena Sibilano, Domenico Buongiorno, Michael Lassi, Antonello Grippo, Valentina Bessi, Sandro Sorbi, Alberto Mazzoni, Vitoantonio Bevilacqua, Antonio Brunetti
The identification of EEG biomarkers to discriminate Subjective Cognitive Decline (SCD) from Mild Cognitive Impairment (MCI) conditions is a complex task which requires great clinical effort and expertise. We exploit the self-attention component of the Transformer architecture to obtain physiological explanations of the model's decisions in the discrimination of 56 SCD and 45 MCI patients using resting-state EEG. Specifically, an interpretability workflow leveraging attention scores and time-frequency analysis of EEG epochs through Continuous Wavelet Transform is proposed...
April 18, 2024: IEEE Journal of Biomedical and Health Informatics
#16
JOURNAL ARTICLE
Qi Zhang, Fangjie Li, Min Wei, Min Wang, Luyao Wang, Ying Han, Jiehui Jiang
BACKGROUND: Predicting cognitive decline in those already Aβ positive or Tau positive among the aging population poses clinical challenges. In Alzheimer's disease (AD) research, intra-default mode network (DMN) connections play a pivotal role in diagnosis. This paper proposes metabolic connectivity within the DMN as a supplementary biomarker to the AT(N) framework. METHODS: Extracting data from 1292 subjects in the Alzheimer's Disease Neuroimaging Initiative, we collected paired T1-weighted structural MRI and 18 F-labeled-fluorodeoxyglucose positron emission computed tomography (PET) scans...
April 15, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#17
JOURNAL ARTICLE
Se-Yeon Min, Nan-Sim Pang, Yu-Ri Kim, Sol-Ah Jeong, Bock-Young Jung
BACKGROUND: This cross-sectional study aimed to identify factors associated with age-related changes in masticatory performance (MP) and oral diadochokinesis (ODK) and to provide normal values in healthy old adults for the diagnosis of oral frailty. METHODS: A total of 385 participants were divided into three age groups (Gr1-3): 20-64 years, 65-74 years, and ≥ 75 years. To investigate tongue-lip motor function, ODK was assessed as the number of repetitions of the monosyllables /pa/ta/ka/...
April 16, 2024: BMC Oral Health
#18
JOURNAL ARTICLE
Zhen Liu, Dai Shi, Yue Cai, Anqi Li, Guoyu Lan, Pan Sun, Lin Liu, Yalin Zhu, Jie Yang, Yajing Zhou, Lizhi Guo, Laihong Zhang, Shuqing Deng, Shuda Chen, Xianfeng Yu, Xuhui Chen, Ruiyue Zhao, Qingyong Wang, Pengcheng Ran, Linsen Xu, Liemin Zhou, Kun Sun, Xinlu Wang, Qiyu Peng, Ying Han, Tengfei Guo
INTRODUCTION: The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge of Alzheimer's disease (AD). However, the characteristics and prevalence of AD in this area are still unclear due to the rarely available community-based neuroimaging AD cohort. METHODS: Following the standard protocols of the Alzheimer's Disease Neuroimaging Initiative, the Greater-Bay-Area Healthy Aging Brain Study (GHABS) was initiated in 2021...
April 16, 2024: Alzheimer's Research & Therapy
#19
JOURNAL ARTICLE
Sivan Raz
A considerable proportion of women subjectively perceive a detriment to their cognitive capacity during pregnancy, with decreased memory functions being the most frequently self-reported concerns. However, objective investigation of these perceived cognitive deficits has yielded inconsistent results. This study focused on memory functions during late pregnancy using multiple tasks designed to assess various memory indices, for example, working memory, learning rate, immediate recall, proactive and retroactive interference, delayed recall, retrieval efficiency, visuospatial constructional ability, recognition, and executive function...
April 15, 2024: Annals of the New York Academy of Sciences
#20
JOURNAL ARTICLE
Soroush Bijani, Fatemeh Sadat Kashfi, Sadaf Zahedi-Vanjani, Keivan Nedaei, Ali Sharafi, Ali Kalantari-Hesari, Mir-Jamal Hosseini
Social isolation can cause serious problem in performance of individuals in community. As gender differences may cause variation results in the severity of depressive behavior and response of patients to therapy, the impact of gender and the interaction of the level of endocrine secretion in depression were investigated in this study. Wistar rats of both sexes were subjected to post-weaning social isolation (PWSI) conditions and, together with the control group, experienced several behavioral tests including open-field Test (OFT), elevated plus maze (EPM), force swimming test (FST), splash test and novel object recognition test (NOR)...
April 15, 2024: Heliyon
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
