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Infectious disease hepatic failure

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https://www.readbyqxmd.com/read/27784430/-prognostic-value-of-a-logistic-regression-model-based-on-keratin-18-in-patients-with-hbv-related-liver-failure
#1
Q R Gan, X Y Jiang, X Zhang, M S Chen, C Pan
Objective: To investigate the association between serum keratin 18 (K18) level and prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). Methods: A total of 120 patients who visited Department of Hepatology in Fuzhou Infectious Disease Hospital and were diagnosed with HBV-related ACLF from December 2012 to March 2014 were enrolled and followed up for 3 months. The patients were divided into death group and survival group. The serum levels of K18 fragments (M30 and M65) were measured and related laboratory data were collected to analyze the differences in M30, M65, M30/M65, and other laboratory markers...
July 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27782894/etiologies-outcomes-and-prognostic-factors-of-pediatric-acute-liver-failure-a-single-center-s-experience-in-turkey
#2
Figen Özçay, Eda Karadağ Öncel, Zeren Barış, Oğuz Canan, Gökhan Moray, Mehmet Haberal
BACKGROUND/AIMS: Our aim was to determine the etiologies, outcomes, and prognostic indicators in children with acute liver failure. MATERIALS AND METHODS: Ninety-one patients who were followed for pediatric acute liver failure (PALF) over a 15-year period were included. Patients who survived with supportive therapy were designated as Group 1, while those who died or underwent liver transplantation were designated as Group 2. RESULTS: There were 37 (40...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27747531/rituximab-for-rheumatoid-arthritis
#3
Marc D Cohen, Edward Keystone
Rituximab is a chimeric monoclonal antibody directed at the CD20 molecule on the surfaces of some but not all B cells. It depletes almost all peripheral B cells, but other niches of B cells are variably depleted, including synovium. Its mechanism of action in rheumatoid arthritis (RA) is only partially understood. Rituximab was efficacious in clinical trials of patients with RA, including those who are methotrexate naïve, those with an incomplete response to methotrexate, and those with an incomplete response to tumor necrosis factor inhibitors...
December 2015: Rheumatol Ther
https://www.readbyqxmd.com/read/27713192/-infectious-diseases-after-lung-transplantation
#4
Yasushi Matsuda, Hideki Mitomo, Tetsu Sado, Masafumi Noda, Miki Akiba, Yoshinori Okada
Lung transplantation is getting to be a common treatment for the end-stage respiratory failure. Therefore we might encounter the various issues associated with infection under immunosuppression. At 1st, virus infections occur by Cytomegalovirus, Epstein-Barr virus, hepatitis B and C virus and John Cunningham virus. The 2nd, bacterial infections exacerbate graft condition by methicillin-resistant Staphylococcus aureus, Pseudomonas, Burkholderia cepacia and coagulase negative staphylococci. The 3rd, fungal infections are induced by Aspergillus, Candida and Cryptococcus...
October 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27677833/parasitic-and-infectious-diseases-of-the-biliary-tract-in-migrants-and-international-travelers
#5
Christoph Lübbert, Sophie Schneitler
In recent years, global and regional crises have led to extraordinary worldwide migration, accompanied by an increase in long-distance travel from Western countries. Both are linked to a rising incidence of rare parasitic and infectious diseases in first world countries, including in the biliary tract. Areas covered: A selective literature research in PubMed was performed to review the most important parasitic and infectious biliary diseases, which are caused by a wide variety of pathogens and may be latent over long periods, with chronic courses leading to cholangitis, hepatic failure or development of cholangiocarcinoma...
October 4, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27403111/orbital-pseudotumor-as-a-rare-extrahepatic-manifestation-of-hepatitis-c-infection
#6
Benjamin Misselwitz, Jana Epprecht, Joachim Mertens, Luc Biedermann, Michael Scharl, Eugenia Haralambieva, Andreas Lutterotti, Konrad P Weber, Beat Müllhaupt, Karla Chaloupka
Hepatitis C is frequently accompanied by immune-related extrahepatic manifestations affecting the skin, kidneys, central and peripheral nervous system and exocrine glands. We present the case of a 40-year-old man with left-sided ptosis, exophthalmos and headache. MRI demonstrated left-sided orbital pseudotumor with lacrimal and retro-orbital contrast enhancement extending to the cavernous sinus and the vestibulocochlear nerve. Immunological tests of serum and cerebrospinal fluid identified hepatitis C virus (HCV) as a potential causative agent but did not indicate any additional infectious, malignant or immunological disorder...
January 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27346103/-the-first-confirmed-imported-case-of-yellow-fever-in-china
#7
X F Dou, Y Zheng, Y N Lyu, J Li, X Y Li, L J Chen, L L Tian, S Li, Y W Chen, X H Pang, X He, Q Y Wang
OBJECTIVE: To describe the epidemiological characteristics of the first confirmed imported case of yellow fever in China. METHODS: This case was reported through the Infectious Disease Surveillance Program. Information on epidemiology and clinical manifestation of the case was collected through case interview and related medical records. Blood and saliva samples of the case were collected and tested by real-time PCR. RESULTS: The patient was male, 32 years old, and suffered a sudden onset of fever without other symptoms, on March 8(th), 2016...
June 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27303136/initial-sequential-organ-failure-assessment-score-versus-simplified-acute-physiology-score-to-analyze-multiple-organ-dysfunction-in-infectious-diseases-in-intensive-care-unit
#8
Remyasri Nair, Nithish M Bhandary, Ashton D D'Souza
AIMS: To investigate initial Sequential Organ Failure Assessment (SOFA) score of patients in Intensive Care Unit (ICU), who were diagnosed with infectious disease, as an indicator of multiple organ dysfunction and to examine if initial SOFA score is a better mortality predictor compared to Simplified Acute Physiology Score (SAPS). MATERIALS AND METHODS: Hospital-based study done in medical ICU, from June to September 2014 with a sample size of 48. Patients aged 18 years and above, diagnosed with infectious disease were included...
April 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27296391/scrub-typhus-in-a-tertiary-care-hospital-in-north-india
#9
Navneet Sharma, Manisha Biswal, Abhay Kumar, Kamran Zaman, Sanjay Jain, Ashish Bhalla
Scrub typhus, a zoonotic disease caused by the bacterium Orientia tsutsugamushi, has become endemic in many parts of India. We studied the clinical profile of this infection in 228 patients that reported to this tertiary care center from July 2013 to December 2014. The median age of patients was 35 years (interquartile range = 24.5-48.5 years), and 111 were males and 117 females. A high-grade fever occurred in 85%, breathlessness in 42%, jaundice in 32%, abdominal pain in 28%, renal failure in 11%, diarrhea in 10%, rashes in 9%, and seizures in 7%...
August 3, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27126766/-living-donor-liver-transplantation-for-the-treatment-complicated-hepatic-cystic-echinococcosis-first-case-report-from-china
#10
Y M Shao, W T Wang, Aji Tuerganaili, T Li, T M Jiang, R Q Zhang, Y B He, M Guo, L N Yan, H Wen
OBJECTIVE: To report the first clinical experience of living donor liver transplantation(LDLT) in patient with complicated hepatic cystic echinococcosis in China. METHODS: First Affiliated Hospital of Xinjiang Medical University successfully implemented LDLT in the treatment of one patient with complicated hepatic cystic echinococcosis after four times liver surgery and secondary congestive cirrhosis on May 9, 2015. The clinical data of the patient has been retrospectively analyzed...
April 26, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27092943/association-of-kidney-disease-measures-with-cause-specific-mortality-the-korean-heart-study
#11
Yejin Mok, Kunihiro Matsushita, Yingying Sang, Shoshana H Ballew, Morgan Grams, Sang Yop Shin, Sun Ha Jee, Josef Coresh
BACKGROUND: The link of low estimated glomerular filtration rate (eGFR) and high proteinuria to cardiovascular disease (CVD) mortality is well known. However, its link to mortality due to other causes is less clear. METHODS: We studied 367,932 adults (20-93 years old) in the Korean Heart Study (baseline between 1996-2004 and follow-up until 2011) and assessed the associations of creatinine-based eGFR and dipstick proteinuria with mortality due to CVD (1,608 cases), cancer (4,035 cases), and other (non-CVD/non-cancer) causes (3,152 cases) after adjusting for potential confounders...
2016: PloS One
https://www.readbyqxmd.com/read/27090203/the-optimal-immunosuppressive-protocol-for-the-portal-vein-infusion-of-pge1-and-methylprednisolone-in-pediatric-liver-transplantation-for-fulminant-hepatic-failure-of-unknown-etiology
#12
Yohei Yamada, Ken Hoshino, Rie Irie, Hirofumi Tomita, Mototoshi Kato, Naoki Shimojima, Akihiro Fujino, Taizo Hibi, Masahiro Shinoda, Hideaki Obara, Osamu Itano, Shigeyuki Kawachi, Minoru Tanabe, Michiie Sakamoto, Yuko Kitagawa, Tatsuo Kuroda
The outcome of LTx in pediatric patients with FHF of unknown etiology remains inferior to that of LTx in pediatric patients with cholestatic diseases. A higher incidence of steroid-resistant severe rejection has been increasingly recognized among the responsible factors. We assessed the efficacy of the administration of steroids and PGE1 via PVI in the management of LTx for FHF in pediatric patients. In our early cohort (1995-2007), seven patients who underwent LTx for FHF of unknown etiology were treated with conventional immunosuppressive therapy (calcineurin inhibitor and a steroid)...
August 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27063467/liver-immunology-and-its-role-in-inflammation-and-homeostasis
#13
REVIEW
Mark W Robinson, Cathal Harmon, Cliona O'Farrelly
The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. However, we now know that the healthy liver is also a site of complex immunological activity mediated by a diverse immune cell repertoire as well as non-hematopoietic cell populations. In the non-diseased liver, metabolic and tissue remodeling functions require elements of inflammation. This inflammation, in combination with regular exposure to dietary and microbial products, creates the potential for excessive immune activation...
May 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27034387/pathology-and-epidemiology-of-stillbirth-in-new-zealand-sea-lions-phocarctos-hookeri-from-enderby-island-auckland-islands-1998-2012
#14
S A Michael, B L Chilvers, S A Hunter, P Duignan, W Roe
Stillbirth is a small and often cryptic fraction of neonatal mortality in mammals including pinnipeds. As part of an investigation into the poor reproductive success of the endangered New Zealand sea lion (Phocarctos hookeri), archived tissues from 37 stillborn pups born on Enderby Island between 1998 and 2012 were examined using histopathological techniques. Apart from bronchopneumonia with neutrophilic infiltration in 4 cases, few inflammatory conditions were identified in stillborn pups. However, 27/32 (84%) stillborn pups had aspirated squames present in the respiratory tract, without meconium...
March 31, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27004027/better-prognosis-in-overweight-obese-coronary-heart-disease-patients-with-high-plasma-levels-of-leptin
#15
Luminita Animarie Vida Simiti, Irina Todor, Mirela Anca Stoia, Cerasela Mihaela Goidescu, Florin Petru Anton, Anca Daniela Farcas
BACKGROUND AND AIM: The involvement of leptin in atherosclerosis is very complex, including inflammation, the oxidative stress and thrombosis. Leptin has atherogenic and also antiatherogenic actions. In obesity elevated leptin levels are not sufficient to prevent disturbances of energy balance, suggesting that obese people are leptin resistant. The aim of the study was to investigate the relationship between baseline plasma levels of leptin and the incidence of new ischemic events in patients with CHD...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/26943982/ckd-and-infectious-diseases-in-asia-pacific-challenges-and-opportunities
#16
Vivekanand Jha, Narayan Prasad
The exact number of patients with chronic kidney disease (CKD) in Asia Pacific is uncertain. In numeric terms, the region is home to the largest population of patients with untreated chronic kidney failure. The climatic, geographic, social, cultural, economic, and environmental diversity within this region is higher than in any other part of the world. Large parts of the region face a climate-related burden of infectious diseases. Infections contribute to the development and progression of CKD and complicate the course of patients with pre-existing CKD (especially those on dialysis therapy or who are immunosuppressed), increase the cost of CKD care, and contribute to mortality and morbidity...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26885544/hepatitis-c-screening-in-people-with-human-immunodeficiency-virus-lessons-learned-from-syphilis-screening
#17
Alysse G Wurcel, Daniel D Chen, Rosemary E Fitzpatrick, Paula E Grasberger, Caleb H Kirshner, Jordan E Anderson, Kenneth K H Chui, Tamsin A Knox
Background.  The incidence of hepatitis C virus (HCV) infection is increasing in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). New guidelines recommend annual screening for HCV, similar to recommendations for syphilis screening with rapid plasma reagin (RPR). Methods.  This study compares the frequency of repeat HCV antibody (Ab) testing to repeat RPR testing in a retrospective chart review of 359 HCVAb-negative people living with HIV (PLWH) observed in an Infectious Diseases clinic...
January 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26809631/-a-case-of-severe-chronic-active-epstein-barr-virus-infection-with-aplastic-anemia-and-hepatitis
#18
Ja In Lee, Sung Won Lee, Nam Ik Han, Sang Mi Ro, Yong-Sun Noh, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
Epstein-Barr virus (EBV) causes various acute and chronic diseases. Chronic active EBV infection (CAEBV) is characterized by infectious mononucleosis-like symptoms that persist for more than 6 months with high viral loads in peripheral blood and/or an unusual pattern of anti-EBV antibodies. Severe CAEBV is associated with poor prognosis with severe symptoms, an extremely high EBV-related antibody titer, and hematologic complications that often include hemophagocytic lymphohistiocytosis. However, CAEBV which led to the development of aplastic anemia (AA) has not been reported yet...
January 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/26719063/modeling-for-critically-ill-patients-an-introduction-for-beginners
#19
Emmanuel Lafont, Saik Urien, Joe-Elie Salem, Nicholas Heming, Christophe Faisy
Models are mathematical tools used to describe real-world features. Therapeutic interventions in the field of critical care medicine may easily be translated into such models. Indeed, numerous variables influencing drug pharmacokinetics and pharmacodynamics are systematically documented in the intensive care unit over time. Organ failure, fluid shifts, other drug administration, and renal replacement therapy may cause changes in physiological values, such as body weight and composition, temperature, serum protein levels, arterial pH, and renal or hepatic function...
December 2015: Journal of Critical Care
https://www.readbyqxmd.com/read/26700085/a-local-experience-of-treatment-response-in-chronic-hepatitis-c-infection
#20
Behzad Bijani, Laleh Ghanei, Amir Mohammad Kazemifar
Hepatitis C virus infection is the major cause of liver cirrhosis. Antiviral treatment can achieve persistent viral clearance to prevent long-term complications of the disease. Despite the introduction of direct acting antivirals (DAAs) as effective therapy in recent years, the standard regimen consisting of interferon and ribavirin which are more accessible and inexpensive is still widely prescribed for the majority of worldwide hepatitis C patients in developing countries. The present study was conducted to demonstrate a local experience of treatment response (with combination therapy; interferon and ribavirin) and outcome in patients with chronic hepatitis C infection...
December 2015: Le Infezioni in Medicina
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