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https://www.readbyqxmd.com/read/28882923/-reframing-healthcare-services-through-the-lens-of-co-production-rhelaunch-a-study-protocol-for-a-mixed-methods-evaluation-of-mechanisms-by-which-healthcare-and-social-services-impact-the-health-and-well-being-of-patients-with-copd-and-chf-in-the-usa-and-the
#1
Gijs Hesselink, Julie Johnson, Paul Batalden, Michelle Carlson, Wytske Geense, Stef Groenewoud, Sylvester Jones, Brita Roy, Christina Sansone, Judith R L M Wolf, Bradley Bart, Hub Wollersheim
INTRODUCTION: The USA lags behind other high-income countries in many health indicators. Outcome differences are associated with differences in the relative spending between healthcare and social services at the national level. The impact of the ratio and delivery of social and healthcare services on the individual patient's health is however unknown. 'Reframing Healthcare Services through the Lens of Co-Production' (RheLaunCh) will be a cross-Atlantic comparative study of the mechanisms by which healthcare and social service delivery may impact patient health with chronic conditions...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28878046/nonlinear-temporal-dynamics-of-cerebral-small-vessel-disease-the-run-dmc-study
#2
Esther M C van Leijsen, Ingeborg W M van Uden, Mohsen Ghafoorian, Mayra I Bergkamp, Valerie Lohner, Eline C M Kooijmans, Helena M van der Holst, Anil M Tuladhar, David G Norris, Ewoud J van Dijk, Loes C A Rutten-Jacobs, Bram Platel, Catharina J M Klijn, Frank-Erik de Leeuw
OBJECTIVE: To investigate the temporal dynamics of cerebral small vessel disease (SVD) by 3 consecutive assessments over a period of 9 years, distinguishing progression from regression. METHODS: Changes in SVD markers of 276 participants of the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) cohort were assessed at 3 time points over 9 years. We assessed white matter hyperintensities (WMH) volume by semiautomatic segmentation and rated lacunes and microbleeds manually...
September 6, 2017: Neurology
https://www.readbyqxmd.com/read/28838198/lessons-from-globally-coordinated-cessation-of-serotype-2-oral-poliovirus-vaccine-for-the-remaining-serotypes
#3
Kimberly M Thompson, Radboud J Duintjer Tebbens
Background: Comparing model expectations with the experience of oral poliovirus vaccine (OPV) containing serotype 2 (OPV2) cessation can inform risk management for the expected cessation of OPV containing serotypes 1 and 3 (OPV13). Methods: We compare the expected post-OPV2-cessation OPV2-related viruses from models with the evidence available approximately 6 months after OPV2 cessation. We also model the trade-offs of use vs nonuse of monovalent OPV (mOPV) for outbreak response considering all 3 serotypes...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838194/lessons-from-the-polio-endgame-overcoming-the-failure-to-vaccinate-and-the-role-of-subpopulations-in-maintaining-transmission
#4
Kimberly M Thompson, Radboud J Duintjer Tebbens
Background: Recent detections of circulating serotype 2 vaccine-derived poliovirus in northern Nigeria (Borno and Sokoto states) and Pakistan (Balochistan Province) and serotype 1 wild poliovirus in Pakistan, Afghanistan, and Nigeria (Borno) represent public health emergencies that require aggressive response. Methods: We demonstrate the importance of undervaccinated subpopulations, using an existing dynamic poliovirus transmission and oral poliovirus vaccine evolution model...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28814852/prognostic-variables-and-scores-identifying-the-end-of-life-in-copd-a-systematic-review
#5
REVIEW
Laura-Jane E Smith, Elizabeth Moore, Ifrah Ali, Liam Smeeth, Patrick Stone, Jennifer K Quint
INTRODUCTION: COPD is a major cause of mortality, and the unpredictable trajectory of the disease can bring challenges to end-of-life care. We aimed to investigate known prognostic variables and scores that predict prognosis in COPD in a systematic literature review, specifically including variables that contribute to risk assessment of patients for death within 12 months. METHODS: We conducted a systematic review on prognostic variables, multivariate score or models for COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814432/minimal-to-no-transfer-of-certolizumab-pegol-into-breast-milk-results-from-cradle-a-prospective-postmarketing-multicentre-pharmacokinetic-study
#6
Megan Eb Clowse, Frauke Förger, Caroline Hwang, John Thorp, Radboud Jem Dolhain, Astrid van Tubergen, Laura Shaughnessy, Jeff Simpson, Marie Teil, Nathalie Toublanc, Maggie Wang, Thomas W Hale
BACKGROUND: Women with chronic inflammatory diseases face uncertainty regarding the safety of biologics during breast feeding. CRADLE was the first industry-sponsored study to evaluate certolizumab pegol (CZP) concentrations in human breast milk and estimate average daily infant dose (ADID) of maternal CZP. METHODS: CRADLE (NCT02154425) was a pharmacokinetic study of lactating mothers receiving CZP. After ≥3 CZP doses, breast milk samples were collected across one dosing period (14 days for 200 mg every 2 weeks [Q2W]; 28 days for 400 mg every 4 weeks [Q4W])...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28738319/meeting-report-intercellular-interactions-in-context-towards-a-mechanistic-understanding-of-cells-in-organs
#7
David Bryant, Aaron Johnson
The Company of Biologists held the workshop 'Intercellular interactions in context: towards a mechanistic understanding of cells in organs' at historic Wiston House in West Sussex, UK, 5-8 February 2017. The meeting brought together around 30 scientists from disparate backgrounds - yet with a common interest of how tissue morphogenesis occurs and its dysregulation leads to pathologies - to intensively discuss their latest research, the current state of the field, as well as any challenges for the future. This report summarises the concepts and challenges that arose as key questions for the fields of cell, cancer and developmental biology...
July 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28696580/empowerment-in-adolescents-and-young-adults-with-cancer-relationship-with-health-related-quality-of-life
#8
Suzanne E J Kaal, Olga Husson, Saskia van Duivenboden, Rosemarie Jansen, Eveliene Manten-Horst, Petra Servaes, Judith B Prins, Sanne W van den Berg, Winette T A van der Graaf
BACKGROUND: The difficulties adolescents and young adults (AYAs) encounter during a cancer experience may result in a reduction in or absence of empowerment. The aims of the current study were to assess levels of empowerment and associated (demographic, clinical, or psychological) factors and examine the association between empowerment and health-related quality of life (HRQOL) among AYA patients with cancer. METHODS: Patients aged 18 to 35 years at time of cancer diagnosis and who were seen by 1 of the members of the specialized multidisciplinary AYA team of the Radboud University Medical Center were invited to complete questionnaires regarding empowerment; HRQOL; and sociodemographic, clinical, and psychological characteristics (autonomy, coping, unmet social support needs, and psychological distress)...
July 11, 2017: Cancer
https://www.readbyqxmd.com/read/28687986/insights-from-a-systematic-search-for-information-on-designs-costs-and-effectiveness-of-poliovirus-environmental-surveillance-systems
#9
REVIEW
Radboud J Duintjer Tebbens, Marita Zimmermann, Mark A Pallansch, Kimberly M Thompson
Poliovirus surveillance plays a critical role in achieving and certifying eradication and will play a key role in the polio endgame. Environmental surveillance can provide an opportunity to detect circulating polioviruses prior to the observation of any acute flaccid paralysis cases. We completed a systematic review of peer-reviewed publications on environmental surveillance for polio including the search terms "environmental surveillance" or "sewage," and "polio," "poliovirus," or "poliomyelitis," and compared characteristics of the resulting studies...
July 7, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28679431/iga-n-and-o-glycosylation-profiling-reveals-no-association-with-the-pregnancy-related-improvement-in-rheumatoid-arthritis
#10
Albert Bondt, Simone Nicolardi, Bas C Jansen, T Martijn Kuijper, Johanna M W Hazes, Yuri E M van der Burgt, Manfred Wuhrer, Radboud J E M Dolhain
BACKGROUND: The Fc glycosylation of immunoglobulin G (IgG) is well known to associate with rheumatoid arthritis (RA) disease activity. The same may be true for other classes of Igs. In the present study, we sought to determine whether the glycosylation of IgA was different between healthy subjects and patients with RA, as well as whether it was associated with RA disease activity, in particular with the pregnancy-associated improvement thereof or the flare after delivery. METHODS: A recently developed high-throughput method for glycoprofiling of IgA1 was applied to affinity-captured IgA from sera of patients with RA (n = 252) and healthy control subjects (n = 32) collected before, during and after pregnancy...
July 5, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28629318/the-effect-of-a-daily-application-of-a-0-05-chlorhexidine-oral-rinse-solution-on-the-incidence-of-aspiration-pneumonia-in-nursing-home-residents-a-multicenter-study
#11
Vanessa R Y Hollaar, Gert-Jan van der Putten, Claar D van der Maarel-Wierink, Ewald M Bronkhorst, Bert J M de Swart, Nico H J Creugers
BACKGROUND: Dysphagia and potential respiratory pathogens in the oral biofilm are risk factors for aspiration pneumonia in nursing home residents. The aim of the study was to examine if the daily application of 0.05% chlorhexidine oral rinse solution is effective in reducing the incidence of aspiration pneumonia in nursing home residents with dysphagia. Associations between background variables (age, gender, dysphagia severity, care dependency, medication use, number of medical diagnoses, teeth and dental implants, and wearing removable dentures) and the incidence of aspiration pneumonia were also examined...
June 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28628474/prediction-of-human-iron-bioavailability-using-rapid-c-elisas-for-human-plasma-hepcidin
#12
Nicole U Stoffel, Christophe Zeder, Eloïse Fort, Dorine W Swinkels, Michael B Zimmermann, Diego Moretti
BACKGROUND: Hepcidin is the central systemic regulator of iron metabolism, but its quantification in biological fluids is challenging. Rapid, accurate and user-friendly methods are needed. Our aim was to assess the ability of hepcidin as measured by three different c-ELISA assays to predict iron bioavailability in humans. METHODS: The three assays used were commercially available DRG and Peninsula assays and the c-ELISA method performed at Radboud University Medical Centre, Nijmegen, The Netherlands (Hepcidinanalysis...
July 26, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28606811/modeling-the-costs-and-benefits-of-temporary-recommendations-for-poliovirus-exporting-countries-to-vaccinate-international-travelers
#13
Radboud J Duintjer Tebbens, Kimberly M Thompson
Recognizing that infectious agents readily cross international borders, the International Health Regulations Emergency Committee issues Temporary Recommendations (TRs) that include vaccination of travelers from countries affected by public health emergencies, including serotype 1 wild polioviruses (WPV1s). This analysis estimates the costs and benefits of TRs implemented by countries with reported WPV1 during 2014-2016 while accounting for numerous uncertainties. We estimate the TR costs based on programmatic data and prior economic analyses and TR benefits by simulating potential WPV1 outbreaks in the absence of the TRs using the rate and extent of WPV1 importation outbreaks per reported WPV1 case during 2004-2013 and the number of reported WPV1 cases that occurred in countries with active TRs...
July 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28601913/the-effects-of-a-non-cognitive-versus-cognitive-admission-procedure-within-cohorts-in-one-medical-school
#14
Marieke de Visser, Cornelia Fluit, Janke Cohen-Schotanus, Roland Laan
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor's curriculum simultaneously...
June 10, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28596069/validation-of-the-effect-questionnaire-for-competence-based-clinical-teaching-in-residency-training-in-lithuania
#15
Eglė Vaižgėlienė, Žilvinas Padaiga, Daiva Rastenytė, Algimantas Tamelis, Kęstutis Petrikonis, Rima Kregždytė, Cornelia Fluit
BACKGROUND AND AIM: In 2013, all residency programs at the Lithuanian University of Health Sciences were renewed into a competency-based medical education curriculum. To assess the quality of clinical teaching in residency training, we chose the EFFECT (evaluation and feedback for effective clinical teaching) questionnaire designed and validated at the Radboud University Medical Centre in the Netherlands. The aim of this study was to validate the EFFECT questionnaire for quality assessment of clinical teaching in residency training...
May 26, 2017: Medicina
https://www.readbyqxmd.com/read/28499744/does-prednisone-use-or-disease-activity-in-pregnant-women-with-rheumatoid-arthritis-influence-the-body-composition-of-their-offspring
#16
Florentien Deirdre Olivia de Steenwinkel, Radboud J E M Dolhain, Johanna M W Hazes, Anita C S Hokken-Koelega
Glucocorticoids are given during pregnancy when rheumatoid arthritis (RA) is too active. It could lead to increased risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) in the offspring. Elevated RA disease activity during pregnancy is associated with low birth weight and rapid post-natal growth. Both can negatively influence the body composition later in life. This study shows that prednisone use or RA disease activity in pregnant women with RA had no influence on the body composition of prepubertal offspring...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28448701/valproate-intoxication-in-a-patient-with-blood-valproate-levels-within-therapeutic-range
#17
Johanna E M P Smits, Eveline Wallenburg, Arno van Spanje, Matthijs van Luin, Radboud M Marijnissen
No abstract text is available yet for this article.
April 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28437234/poliovirus-vaccination-during-the-endgame-insights-from-integrated-modeling
#18
Radboud J Duintjer Tebbens, Kimberly M Thompson
Managing the polio endgame requires access to sufficient quantities of poliovirus vaccines. After oral poliovirus vaccine (OPV) cessation, outbreaks may occur that require outbreak response using monovalent OPV (mOPV) and/or inactivated poliovirus vaccine. Areas covered: We review the experience and challenges with managing vaccine supplies in the context of the polio endgame. Building on models that explored polio endgame risks and the potential mOPV needs to stop outbreaks from live poliovirus reintroductions, we conceptually explore the potential demands for finished and bulk mOPV doses from a stockpile in the context of limited shelf-life of finished vaccine and time delays to convert bulk to finished vaccine...
May 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28390565/fertility-pregnancy-and-lactation-in-rheumatoid-arthritis
#19
REVIEW
Pascal H P de Jong, Radboud J E M Dolhain
Fertility is impaired in women with rheumatoid arthritis (RA), whereas less is known about male fertility problems. Pregnancy outcome in patients with RA is slightly less favorable compared with the general population, especially in patients with active disease. Disease activity usually improves during pregnancy, but less than previously thought. Although several antirheumatic drugs are contraindicated in pregnancy, more treatment options are available. There is evidence on the safety of TNF inhibitors in pregnancy...
May 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28382713/ultra-small-superparamagnetic-iron-oxides-for-metastatic-lymph-node-detection-back-on-the-block
#20
REVIEW
Ansje S Fortuin, Roger Brüggemann, Janine van der Linden, Ilia Panfilov, Bas Israël, Tom W J Scheenen, Jelle O Barentsz
In the past 15 years, encouraging clinical results for the detection of small lymph node metastases was obtained by the use of Combidex-enhanced MRI (CEM, also known as magnetic resonance lymphography). Withdrawal of the European Medicines Agency approval application by the manufacturer made it impossible for patients to benefit from this agent; a loss, especially for men with prostate cancer. Current conventional imaging techniques are not as accurate as CEM is, thus a surgical diagnostic exploration (extended lymph node dissection) is still the preferred technique to evaluate the lymph nodes, resulting in peri- and postoperative complications...
April 6, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
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