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https://www.readbyqxmd.com/read/28499744/does-prednisone-use-or-disease-activity-in-pregnant-women-with-rheumatoid-arthritis-influence-the-body-composition-of-their-offspring
#1
Florentien Deirdre Olivia de Steenwinkel, Radboud J E M Dolhain, Johanna M W Hazes, Anita C S Hokken-Koelega
Glucocorticoids are given during pregnancy when rheumatoid arthritis (RA) is too active. It could lead to increased risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) in the offspring. Elevated RA disease activity during pregnancy is associated with low birth weight and rapid post-natal growth. Both can negatively influence the body composition later in life. This study shows that prednisone use or RA disease activity in pregnant women with RA had no influence on the body composition of prepubertal offspring...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28448701/valproate-intoxication-in-a-patient-with-blood-valproate-levels-within-therapeutic-range
#2
Johanna E M P Smits, Eveline Wallenburg, Arno van Spanje, Matthijs van Luin, Radboud M Marijnissen
No abstract text is available yet for this article.
April 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28437234/poliovirus-vaccination-during-the-endgame-insights-from-integrated-modeling
#3
Radboud J Duintjer Tebbens, Kimberly M Thompson
Managing the polio endgame requires access to sufficient quantities of poliovirus vaccines. After oral poliovirus vaccine (OPV) cessation, outbreaks may occur that require outbreak response using monovalent OPV (mOPV) and/or inactivated poliovirus vaccine. Areas covered: We review the experience and challenges with managing vaccine supplies in the context of the polio endgame. Building on models that explored polio endgame risks and the potential mOPV needs to stop outbreaks from live poliovirus reintroductions, we conceptually explore the potential demands for finished and bulk mOPV doses from a stockpile in the context of limited shelf-life of finished vaccine and time delays to convert bulk to finished vaccine...
May 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28390565/fertility-pregnancy-and-lactation-in-rheumatoid-arthritis
#4
REVIEW
Pascal H P de Jong, Radboud J E M Dolhain
Fertility is impaired in women with rheumatoid arthritis (RA), whereas less is known about male fertility problems. Pregnancy outcome in patients with RA is slightly less favorable compared with the general population, especially in patients with active disease. Disease activity usually improves during pregnancy, but less than previously thought. Although several antirheumatic drugs are contraindicated in pregnancy, more treatment options are available. There is evidence on the safety of TNF inhibitors in pregnancy...
May 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28382713/ultra-small-superparamagnetic-iron-oxides-for-metastatic-lymph-node-detection-back-on-the-block
#5
REVIEW
Ansje S Fortuin, Roger Brüggemann, Janine van der Linden, Ilia Panfilov, Bas Israël, Tom W J Scheenen, Jelle O Barentsz
In the past 15 years, encouraging clinical results for the detection of small lymph node metastases was obtained by the use of Combidex-enhanced MRI (CEM, also known as magnetic resonance lymphography). Withdrawal of the European Medicines Agency approval application by the manufacturer made it impossible for patients to benefit from this agent; a loss, especially for men with prostate cancer. Current conventional imaging techniques are not as accurate as CEM is, thus a surgical diagnostic exploration (extended lymph node dissection) is still the preferred technique to evaluate the lymph nodes, resulting in peri- and postoperative complications...
April 6, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28336786/-18-f-fdg-pet-ct-optimizes-treatment-in-staphylococcus-aureus-bacteremia-and-is-associated-with-reduced-mortality
#6
Marvin A H Berrevoets, Ilse J E Kouijzer, Erik H J G Aarntzen, Marcel J R Janssen, Lioe-Fee De Geus-Oei, Heiman F L Wertheim, Bart-Jan Kullberg, Jaap Ten Oever, Wim J G Oyen, Chantal P Bleeker-Rovers
Metastatic infection is an important complication of Staphylococcus aureus bacteremia (SAB). Early diagnosis of metastatic infection is crucial, as specific treatment is required. However, metastatic infection can be asymptomatic and difficult to detect. In this study, we investigated the role of (18)F-FDG-PET/CT in patients with SAB for detection of metastatic infection and its consequences for treatment and outcome. Methods: All patients with SAB at Radboud university medical center were included between January 2013 and April 2016...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28331838/bibliometric-analysis-of-literature-on-antifungal-triazole-resistance-1980-2015
#7
Waleed M Sweileh, Ansam F Sawalha, Samah Al-Jabi, Sa'ed H Zyoud
BACKGROUND: Triazole antifungal agents play an important role in the treatment of a wide range of fungal infections. Little is known about antifungal triazole drug resistance when compared to antibiotic resistance. Therefore, this study was carried out to give a bibliometric overview of literature on triazole antifungal drug resistance. METHODS: Keywords related to triazole drug class and resistance were used in a search query in the Scopus search engine. The time span was set from 1980 to 2015...
March 2017: Germs
https://www.readbyqxmd.com/read/28326601/quantitative-analysis-of-eyes-and-other-optical-systems-in-linear-optics
#8
William F Harris, Tanya Evans, Radboud D van Gool
PURPOSE: To show that 14-dimensional spaces of augmented point P and angle Q characteristics, matrices obtained from the ray transference, are suitable for quantitative analysis although only the latter define an inner-product space and only on it can one define distances and angles. The paper examines the nature of the spaces and their relationships to other spaces including symmetric dioptric power space. METHODS: The paper makes use of linear optics, a three-dimensional generalization of Gaussian optics...
March 21, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28325747/brief-fixation-enables-same-day-breast-cancer-diagnosis-with-reliable-assessment-of-hormone-receptors-e-cadherin-and-her2-neu
#9
Altuna Halilovic, Joris Bulte, Yvonne Jacobs, Hanneke Braam, Patricia van Cleef, Margrethe Schlooz-Vries, Annelies Werner, Oliver Boelens, Iris Nagtegaal, Hans de Wilt, Peter Bult
AIMS: Preoperative core needle biopsy (CNB) is commonly used to confirm the diagnosis of breast cancer. For treatment purposes and for determining histological type, especially in case of neoadjuvant therapy, oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status and E-cadherin assessments are crucial. Considering the increasing demand for same-day diagnosis of breast lesions, an accelerated method of CNB processing was developed, in which the tissue fixation time is radically reduced...
March 21, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28323534/children-s-recognition-of-emotional-facial-expressions-through-photographs-and-drawings
#10
Claire Brechet
The author's purpose was to examine children's recognition of emotional facial expressions, by comparing two types of stimulus: photographs and drawings. The author aimed to investigate whether drawings could be considered as a more evocative material than photographs, as a function of age and emotion. Five- and 7-year-old children were presented with photographs and drawings displaying facial expressions of 4 basic emotions (i.e., happiness, sadness, anger, and fear) and were asked to perform a matching task by pointing to the face corresponding to the target emotion labeled by the experimenter...
March 2017: Journal of Genetic Psychology
https://www.readbyqxmd.com/read/28251678/costs-and-clinical-outcomes-of-implant-placement-during-ablative-surgery-and-postponed-implant-placement-in-curative-oral-oncology-a-five-year-retrospective-cohort-study
#11
Jan-Willem G H Wetzels, Gert J Meijer, Ron Koole, Eddy M Adang, Matthias A W Merkx, Caroline M Speksnijder
OBJECTIVES: The aim of this study was to compare costs and clinical outcomes of two protocols for implant placement in edentulous oral cancer patients: implant placement during ablative surgery and postponed implant placement. MATERIAL AND METHODS: All edentulous patients who underwent curative tumor surgery between 2007 and 2009 at the Radboud university medical center (Radboudumc) and UMC Utrecht, both in the Netherlands, were included retrospectively. At the Radboudumc, 79 of 98 patients received implants during ablative surgery...
March 2, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28202228/cross-institutional-knowledge-based-planning-kbp-implementation-and-its-performance-comparison-to-auto-planning-engine-ape
#12
Binbin Wu, Martijn Kusters, Martina Kunze-Busch, Tim Dijkema, Todd McNutt, Giuseppe Sanguineti, Karl Bzdusek, Anatoly Dritschilo, Dalong Pang
BACKGROUND AND PURPOSE: To investigate (1) whether a plan library established at one institution can be applied for another institution's knowledge-based planning (KBP); (2) the performance of cross-institutional KBP compared to Auto-Planning Engine (APE). MATERIAL AND METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (68Gy to PTV(68) and 50.3Gy to PTV(50.3)) with clinically-delivered and comparative APE plans. The Johns Hopkins University (JHU) contributed a three-dose-level plan library consisting of 179 clinically-delivered plans...
February 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28140671/comparison-of-three-methods-of-rating-nasolabial-appearance-in-cleft-lip-and-palate
#13
Sylwia A Fudalej, Dries Desmedt, Ewald Bronkhorst, Piotr S Fudalej
OBJECTIVE:   To investigate which of three methods of rating nasolabial appearance-esthetic index, visual analogue scale (VAS), or numerical scale with reference photographs-is optimal. DESIGN:   Experimental study. SETTING:   Radboud University Medical Centre, The Netherlands and University of Bern, Switzerland. SUBJECTS AND METHODS:   Cropped photographs of 60 patients with complete unilateral cleft lip and palate (mean age = 10...
January 31, 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28097370/osseointegrated-prosthesis-for-patients-with-an-amputation-multidisciplinary-team-approach-in-the-netherlands
#14
J P M Frölke, R A Leijendekkers, H van de Meent
This article reviews the development of multidisciplinary osseointegration treatment in the Netherlands since its start in 2009. People experiencing limitations due to their socket prosthesis after a leg amputation present to the Radboud University Nijmegen Medical Centre for an osseointegration implant or "bone-anchored" prosthesis. In this article we share our experience with the first 100 patients regarding referral pattern, selection criteria, available osseointegration systems, preoperative planning, surgical treatment, the rehabilitation protocol, outcome measurement, revision surgery, and future developments...
April 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28046761/mo-g-201-01-a-multi-institutional-study-investigating-the-performance-of-a-knowledge-based-planning-system-against-pinnacle-auto-planning-engine-in-sib-imrt-for-the-head-and-neck-cancer
#15
B Wu, M Kusters, M Kunze-Busch, T Dijkema, T McNutt, G Sanguineti, D Pang
PURPOSE: Knowledge-based Planning (KBP) founded on prior planning experience and Auto-Planning Engine (APE; commercialized in Pinnacle v9.10 TPS) based on progressive optimization algorithm both aim to eliminate the trial-and-error process in radiotherapy inverse planning. This study investigates the performance of the approaches in a multi-institutional setting to evaluate their functionalities in oropharyngeal cancer and offers suggestions how they can be implemented in the clinic. METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (SIB-IMRT with two-dose-level prescription: 68 Gy to PTV68 and 50...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28009475/reactivation-of-latent-hpv-infections-after-renal-transplantation
#16
F Hinten, L B Hilbrands, K A P Meeuwis, J IntHout, W G V Quint, A J Hoitsma, L F A G Massuger, W J G Melchers, J A de Hullu
Female renal transplant recipients (RTRs) have an increased risk for developing human papillomavirus (HPV)-related (pre)malignant lesions of the genital tract. This study aims to assess the genital prevalence of HPV before and after renal transplantation (RT). In female patients who were counseled for RT at the Radboud University Medical Center Nijmegen, the Netherlands, gynecological examination was performed at first visit, and 1 and 2 years later. HPV self-sampling and questionnaires on sexual behavior were performed every 3 months...
December 23, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27928745/perceived-emotion-genuineness-normative-ratings-for-popular-facial-expression-stimuli-and-the-development-of-perceived-as-genuine-and-perceived-as-fake-sets
#17
Amy Dawel, Luke Wright, Jessica Irons, Rachael Dumbleton, Romina Palermo, Richard O'Kearney, Elinor McKone
In everyday social interactions, people's facial expressions sometimes reflect genuine emotion (e.g., anger in response to a misbehaving child) and sometimes do not (e.g., smiling for a school photo). There is increasing theoretical interest in this distinction, but little is known about perceived emotion genuineness for existing facial expression databases. We present a new method for rating perceived genuineness using a neutral-midpoint scale (-7 = completely fake; 0 = don't know; +7 = completely genuine) that, unlike previous methods, provides data on both relative and absolute perceptions...
December 7, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27898224/recommended-reading-from-radboud-university-medical-centre-fellows
#18
Willem-Jan M Schellekens, Diana Jansen, Mirrin J Dorresteijn, Leo M A Heunks
No abstract text is available yet for this article.
November 29, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27887659/fab-glycosylation-of-immunoglobulin-g-does-not-associate-with-improvement-of-rheumatoid-arthritis-during-pregnancy
#19
Albert Bondt, Manfred Wuhrer, T Martijn Kuijper, Johanna M W Hazes, Radboud J E M Dolhain
BACKGROUND: Changes in immunoglobulin G (IgG) constant domain (Fc) glycosylation are associated with changes in rheumatoid arthritis (RA) disease activity in response to pregnancy. Here, we sought to determine whether the same holds true for variable domain (Fab) glycosylation. METHODS: IgGs were captured from RA and control sera obtained before (RA only), during and after pregnancy, followed by Fc and Fab separation, glycan release, and mass spectrometric detection...
November 25, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27865797/radboud-centre-for-mitochondrial-medicine-pediatric-mri-score
#20
Sheila Suet-Na Wong, Bozena Goraj, Cheuk-Wing Fung, Jeroen Vister, Lonneke de Boer, Saskia Koene, Jan Smeitink
We developed the first user-friendly, semi-quantitative, and quick-to-perform Radboud Centre for Mitochondrial Medicine Pediatric MRI score (RCMM-PMRIS), focusing on the six most commonly described neuroimaging abnormalities in the literature. The RCMM-PMRIS was validated through individual review of 30 sets of brain MRI studies in 24 patients with genetically confirmed mitochondrial disorders by six raters. The application of RCMM-PMRIS can help to define the extent of the brain involvement and therefore to assess the radiological mitochondrial disease severity, to monitor disease progression and consequently to act as an outcome measure for treatment effects in patients with mitochondrial disease...
January 2017: Mitochondrion
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