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https://www.readbyqxmd.com/read/27898224/recommended-reading-from-radboud-university-medical-centre-fellows
#1
Willem-Jan M Schellekens, Diana Jansen, Mirrin J Dorresteijn, Leo M A Heunks
No abstract text is available yet for this article.
November 29, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27887659/fab-glycosylation-of-immunoglobulin-g-does-not-associate-with-improvement-of-rheumatoid-arthritis-during-pregnancy
#2
Albert Bondt, Manfred Wuhrer, T Martijn Kuijper, Johanna M W Hazes, Radboud J E M Dolhain
BACKGROUND: Changes in immunoglobulin G (IgG) constant domain (Fc) glycosylation are associated with changes in rheumatoid arthritis (RA) disease activity in response to pregnancy. Here, we sought to determine whether the same holds true for variable domain (Fab) glycosylation. METHODS: IgGs were captured from RA and control sera obtained before (RA only), during and after pregnancy, followed by Fc and Fab separation, glycan release, and mass spectrometric detection...
November 25, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27865797/radboud-centre-for-mitochondrial-medicine-pediatric-mri-score
#3
Sheila Suet-Na Wong, Bozena Goraj, Cheuk-Wing Fung, Jeroen Vister, Lonneke de Boer, Saskia Koene, Jan Smeitink
We developed the first user-friendly, semi-quantitative, and quick-to-perform Radboud Centre for Mitochondrial Medicine Pediatric MRI score (RCMM-PMRIS), focusing on the six most commonly described neuroimaging abnormalities in the literature. The RCMM-PMRIS was validated through individual review of 30 sets of brain MRI studies in 24 patients with genetically confirmed mitochondrial disorders by six raters. The application of RCMM-PMRIS can help to define the extent of the brain involvement and therefore to assess the radiological mitochondrial disease severity, to monitor disease progression and consequently to act as an outcome measure for treatment effects in patients with mitochondrial disease...
November 16, 2016: Mitochondrion
https://www.readbyqxmd.com/read/27853908/implementing-medical-teaching-policy-in-university-hospitals
#4
Rik Engbers, Cornelia R M G Fluit, Sanneke Bolhuis, Marieke de Visser, Roland F J M Laan
Within the unique and complex settings of university hospitals, it is difficult to implement policy initiatives aimed at developing careers in and improving the quality of academic medical teaching because of the competing domains of medical research and patient care. Factors that influence faculty in making use of teaching policy incentives have remained underexplored. Knowledge of these factors is needed to develop theory on the successful implementation of medical teaching policy in university hospitals...
November 16, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27831742/the-potential-benefits-of-a-new-poliovirus-vaccine-for-long-term-poliovirus-risk-management
#5
Radboud J Duintjer Tebbens, Kimberly M Thompson
AIM: To estimate the incremental net benefits (INBs) of a hypothetical ideal vaccine with all of the advantages and no disadvantages of existing oral and inactivated poliovirus vaccines compared with current vaccines available for future outbreak response. METHODS: INB estimates based on expected costs and polio cases from an existing global model of long-term poliovirus risk management. RESULTS: Excluding the development costs, an ideal poliovirus vaccine could offer expected INBs of US$1...
November 10, 2016: Future Microbiology
https://www.readbyqxmd.com/read/27813290/identifying-clinical-factors-associated-with-low-disease-activity-and-remission-of-rheumatoid-arthritis-during-pregnancy
#6
Hilal Ince-Askan, Johanna M W Hazes, Radboud J E M Dolhain
OBJECTIVES: To identify a combination of clinical factors associated with low disease activity and remission in the third trimester during pregnancy in women with Rheumatoid Arthritis(RA). METHODS: This study is embedded in the Pregnancy induced Amelioration of Rheumatoid Arthritis(PARA)-study, a prospective cohort study. There was data available on 190 pregnancies from first trimester unto delivery. Multivariate regression analyses were performed on the disease activity(DAS28-CRP3) in the third trimester...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27723275/subfertility-in-rheumatoid-arthritis-is-often-unexplained-or-caused-by-anovulation
#7
Jenny Brouwer, Rosalie Fleurbaaij, Johanna M W Hazes, Radboud J E M Dolhain, Joop S E Laven
Objective - Subfertility is frequently encountered amongst female rheumatoid arthritis (RA) patients and has been associated with disease activity and anti-rheumatic drugs. However, little is known about the results of the fertility work-up in these women. Our aim was to study the outcome of fertility assessments in subfertile women with RA. Methods - A cross-sectional study was performed in a nationwide cohort of female RA patients who were pregnant or were trying to conceive between 2002 and 2010 (PARA study)...
October 9, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27718521/validation-of-the-simplified-psoriasis-index-spi-in-dutch-children-and-adolescents-with-plaque-psoriasis
#8
M J van Geel, M E Otero, E M G J de Jong, P C M van de Kerkhof, M M B Seyger
BACKGROUND: The Simplified Psoriasis Index (SPI) is a three-domain assessment measure for psoriasis, including separate indicators of current severity (SPI-s), psychosocial impact (SPI-p), and past history and interventions (SPI-i). There are two complementary versions available designed for completion by a health professional (proSPI) or by patient self-assessment (saSPI). The validity and reliability of proSPI versus saSPI have already been demonstrated in adults. To date, validated severity measures for pediatric psoriasis do not exist...
October 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27713763/in-hospital-costs-of-an-admission-for-adhesive-small-bowel-obstruction
#9
Pepijn Krielen, Barend A van den Beukel, Martijn W J Stommel, Harry van Goor, Chema Strik, Richard P G Ten Broek
BACKGROUND: Previous research on the costs of treatment for ASBO is outdated and often based on reimbursements, rather than true healthcare provider costs of the admission and related interventions. An accurate estimate of the true costs of treatment is necessary to understand the healthcare burden and to model cost-efficacy of adhesion strategies. The aim of this study was to provide an accurate cost estimate of the in-hospital costs for treatment of adhesive small bowel obstruction (ASBO) using micro-costing methods...
2016: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/27706913/longitudinal-retention-of-anatomical-knowledge-in-second-year-medical-students
#10
Denise E Doomernik, Harry van Goor, Jan G M Kooloos, Richard P Ten Broek
The Radboud University Medical Center has a problem-based, learner-oriented, horizontally, and vertically integrated medical curriculum. Anatomists and clinicians have noticed students' decreasing anatomical knowledge and the disability to apply knowledge in diagnostic reasoning and problem solving. In a longitudinal cohort, the retention of anatomical knowledge gained during the first year of medical school among second-year medical students was assessed. In May 2011, 346 medical students applied for the second-year gastro-intestinal (GI) tract course...
October 5, 2016: Anatomical Sciences Education
https://www.readbyqxmd.com/read/27696568/postural-orthostatic-tachycardia-is-not-a-useful-diagnostic-marker-for-chronic-fatigue-syndrome
#11
M E Roerink, J W M Lenders, I C Schmits, A M A Pistorius, J W Smit, H Knoop, J W M van der Meer
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is considered a diagnostic marker for chronic fatigue syndrome (CFS). OBJECTIVES: The aims of this study were to (i) compare POTS prevalence in a CFS cohort with fatigued patients not meeting CFS criteria, and (ii) assess activity, impairment and response to cognitive behavioural therapy (CBT) in CFS patients with POTS (POTS-CFS) and without POTS (non-POTS-CFS). METHODS: Prospective cohort study at the Radboud University Medical Centre in the Netherlands...
October 2, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27624148/effects-of-tetrahydrocannabinol-on-balance-and-gait-in-patients-with-dementia-a-randomised-controlled-crossover-trial
#12
Geke Ah van den Elsen, Lieke Tobben, Amir Ia Ahmed, Robbert Jan Verkes, Cornelis Kramers, Radboud M Marijnissen, Marcel Gm Olde Rikkert, Marjolein A van der Marck
Oral tetrahydrocannabinol (THC) is currently studied for its possible efficacy on dementia-related neuropsychiatric symptoms (NPS), but might lead to increased risk of falling. This was a randomised, double-blind, crossover study to evaluate the effects of THC on mobility in dementia patients. Eighteen community-dwelling patients (Mage=77 years) received 1.5 mg of oral THC twice daily and placebo, in random order, for three days, separated by a four-day washout. Balance and gait were assessed using SwayStar(TM) and GAITRite(TM) within two hours after administration, in two consecutive intervention periods, under the following conditions: standing with eyes open (EO) and eyes closed (EC), preferred speed walking with and without a cognitive dual task...
September 13, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27619828/improving-care-for-victims-a-study-protocol-of-the-evaluation-of-a-centre-for-sexual-and-family-violence
#13
E Zijlstra, S LoFoWong, G Hutschemaekers, A Lagro-Janssen
INTRODUCTION: Worldwide, sexual and family violence are highly prevalent problems. Victims of sexual and family violence often do not seek formal help in the acute phase. When they do seek help, they encounter a system of scattered care. For this reason, a centre for sexual and family violence was launched in Nijmegen, the Netherlands. The centre provides multidisciplinary care for victims of acute sexual and/or family violence. With the study described in this study protocol, we want to evaluate the implementation process and the reach of the Center for Sexual and Family Violence Nijmegen (CSFVN)...
September 12, 2016: BMJ Open
https://www.readbyqxmd.com/read/27613712/pathophysiology-underlying-drooling-in-parkinson-s-disease-oropharyngeal-bradykinesia
#14
Mehmet Karakoc, Mehmet Ilker Yon, Gul Yalcin Cakmakli, Ersin Kasim Ulusoy, Aydin Gulunay, Nese Oztekin, Fikri Ak
We aimed to investigate the association between drooling and possible etiological factors in Parkinson's disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson's disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Parkinson gait scale (DYPAGS) was administered for the objective quantification of PD gait features...
December 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27541801/high-dose-intravenous-pulse-methotrexate-in-patients-with-eosinophilic-fasciitis
#15
Jorre S Mertens, Manon C Zweers, Wietske Kievit, Hanneke K A Knaapen, Martijn Gerritsen, Timothy R D J Radstake, Frank H J van den Hoogen, Marjonne C W Creemers, Elke M G J de Jong
Importance: Eosinophilic fasciitis (EF) is a connective tissue disorder in which conventional treatment leads to disappointing results in a proportion of patients. Therefore, we investigated high-dose intravenous (IV) pulse methotrexate (MTX) as a treatment for EF. Objective: To examine safety and effects of monthly high-dose IV pulse MTX in EF. Design, Setting, and Participants: For this prospective single-arm study, we recruited 12 patients diagnosed with biopsy specimen-proven EF between 2006 and 2009 from the Department of Dermatology and Rheumatology at the Radboud University Medical Centre...
August 17, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27521430/late-onset-depressive-symptoms-increase-the-risk-of-dementia-in-small-vessel-disease
#16
Ingeborg W M van Uden, Helena M van der Holst, Esther M C van Leijsen, Anil M Tuladhar, Anouk G W van Norden, Karlijn F de Laat, Jurgen A H R Claassen, Ewoud J van Dijk, Roy P C Kessels, Edo Richard, Indira Tendolkar, Frank-Erik de Leeuw
OBJECTIVE: We prospectively investigated the role of depressive symptoms (DS) on all-cause dementia in a population with small vessel disease (SVD), considering onset age of DS and cognitive performance. METHODS: The RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort) is a prospective cohort study among 503 older adults with SVD on MRI without dementia at baseline (2006), with a follow-up of 5 years (2012). Kaplan-Meier curves stratified for DS and dementia risk were compared using log-rank test...
September 13, 2016: Neurology
https://www.readbyqxmd.com/read/27455960/the-effectiveness-of-a-nurse-led-intervention-with-the-distress-thermometer-for-patients-treated-with-curative-intent-for-breast-cancer-design-of-a-randomized-controlled-trial
#17
Floortje K Ploos van Amstel, Judith B Prins, Winette T A van der Graaf, Marlies E W J Peters, Petronella B Ottevanger
BACKGROUND: Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial consequences of the systematic use of the DT and its discussion by a nurse as compared to the usual care provided to outpatients who are treated for primary breast cancer is needed...
July 25, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27430397/very-high-uptake-of-risk-reducing-salpingo-oophorectomy-in-brca1-2-mutation-carriers-a-single-center-experience
#18
M G Harmsen, M Arts-de Jong, K Horstik, P Manders, L F A G Massuger, R P M G Hermens, N Hoogerbrugge, G H Woldringh, J A de Hullu
OBJECTIVE: Risk-reducing salpingo-oophorectomy (RRSO) is the only effective surgical strategy to reduce the increased risk of epithelial ovarian cancer in BRCA1/2 mutation carriers. Given the long-term health consequences of premature surgical menopause, we need insight in uptake and timing of RRSO to guide us in improving healthcare. METHODS: A single-center retrospective cohort study of BRCA1/2 mutation carriers diagnosed and counseled at the multidisciplinary Family Cancer Clinic of the Radboud university medical center in Nijmegen, The Netherlands, between 1999 and 2014...
October 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27406950/prediction-model-for-obtaining-spermatozoa-with-testicular-sperm-extraction-in-men-with-non-obstructive-azoospermia
#19
M Cissen, A M Meijerink, K W D'Hauwers, A Meissner, N van der Weide, M H Mochtar, A A de Melker, L Ramos, S Repping, D D M Braat, K Fleischer, M van Wely
STUDY QUESTION: Can an externally validated model, based on biological variables, be developed to predict successful sperm retrieval with testicular sperm extraction (TESE) in men with non-obstructive azoospermia (NOA) using a large nationwide cohort? SUMMARY ANSWER: Our prediction model including six variables was able to make a good distinction between men with a good chance and men with a poor chance of obtaining spermatozoa with TESE. WHAT IS KNOWN ALREADY: Using ICSI in combination with TESE even men suffering from NOA are able to father their own biological child...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27406949/prediction-model-for-live-birth-in-icsi-using-testicular-extracted-sperm
#20
A M Meijerink, M Cissen, M H Mochtar, K Fleischer, I Thoonen, A A de Melker, A Meissner, S Repping, D D M Braat, M van Wely, L Ramos
STUDY QUESTION: Which parameters have a predictive value for live birth in couples undergoing ICSI after successful testicular sperm extraction (TESE-ICSI)? SUMMARY ANSWER: Female age, a first or subsequent started TESE-ICSI cycle, male LH, male testosterone, motility of the spermatozoa during the ICSI procedure and the initial male diagnosis before performing TESE were identified as relevant and independent parameters for live birth after TESE-ICSI. WHAT IS KNOWN ALREADY: In reproductive medicine prediction models are used frequently to predict treatment success, but no prediction model currently exists for live birth after TESE-ICSI...
September 2016: Human Reproduction
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