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https://www.readbyqxmd.com/read/29786664/enable-2017-the-first-european-phd-and-post-doc-symposium-session-3-in-vitro-to-in-vivo-modeling-life-in-3d
#1
Gianmarco Di Mauro, Ambra Dondi, Giovanni Giangreco, Alexander Hogrebe, Elja Louer, Elisa Magistrati, Meeli Mullari, Gemma Turon, Wouter Verdurmen, Helena Xicoy Cortada, Sanja Zivanovic
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European research institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research-NNF CPR, Denmark; European School of Molecular Medicine-SEMM, Italy) and an innovative science communication agency (Scienseed). With the aim to promote biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event...
May 22, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29785679/drooling-in-parkinson-s-disease-evidence-of-a-role-for-divided-attention
#2
Hannah Reynolds, Nick Miller, Richard Walker
Drooling is a frequently reported symptom in Parkinson's Disease (PD) with significant psychosocial impact and negative health consequences including silent aspiration of saliva with the associated risk of respiratory infections. It is suggested that in PD drooling is associated with inefficient oropharyngeal swallowing which reduces the effective clearance of saliva rather than hyper-salivation. This is compounded by unintended mouth opening and flexed posture increasing anterior loss of saliva. It is reported to occur most frequently during cognitively distracting concurrent tasks suggesting an impact from divided attention in a dual-task situation...
May 21, 2018: Dysphagia
https://www.readbyqxmd.com/read/29785147/selection-as-a-learning-experience-an-exploratory-study
#3
Marieke de Visser, Roland F Laan, Rik Engbers, Janke Cohen-Schotanus, Cornelia Fluit
Introduction: Research on selection for medical school does not explore selection as a learning experience, despite growing attention for the learning effects of assessment in general. Insight in the learning effects allows us to take advantage of selection as an inclusive part of medical students' learning process to become competent professionals. The aims of this study at Radboud University Medical Center, the Netherlands, were 1) to determine whether students have learning experiences in the selection process, and, if so, what experiences; and 2) to understand what students need in order to utilize the learning effects of the selection process at the start of the formal curriculum...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29754157/-patient-satisfaction-with-procedural-sedation-in-oral-and-maxillofacial-surgery
#4
J T Deferm, M Burger, T Prudon, M van Bergen, M Vaneker, W A Borstlap
Fear of treatment by an oral and maxillofacial (OMF) surgeon or the dentist is a widespread and deep-rooted phenomenon. A patient can be taught to cope with dental phobia by means of psychological, cognitive behavioural therapy, but in cases of invasive oral treatment, such therapy may be insufficiently effective. For these invasive procedures, sedation serves as an alternative treatment option. The department of Oral and Maxillofacial Surgery at the Radboud University Medical Centre in Nijmegen, the Netherlands, offers the possibility to utilise intravenous sedation with midazolam (Dormicum®) and remifentanil (Ultiva®)...
May 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29724890/progression-of-white-matter-hyperintensities-preceded-by-heterogeneous-decline-of-microstructural-integrity
#5
Esther M C van Leijsen, Mayra I Bergkamp, Ingeborg W M van Uden, Mohsen Ghafoorian, Helena M van der Holst, David G Norris, Bram Platel, Anil M Tuladhar, Frank-Erik de Leeuw
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when progression of WMH was preceded by changes in fluid-attenuated inversion recovery and diffusion tensor imaging values, thereby taking into account differences between participants with mild versus severe baseline WMH...
May 3, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29697426/does-mindfulness-training-enhance-the-professional-development-of-residents-a-qualitative-study
#6
Hanne Verweij, Hiske van Ravesteijn, Madelon L M van Hooff, Antoine L M Lagro-Janssen, Anne E M Speckens
PURPOSE: In addition to developing diagnostic and clinical skills, postgraduate medical education should stimulate residents' professional development. Teaching medical professionalism is challenging and is often left largely to the informal and hidden curricula. An intervention that might be beneficial for medical residents is Mindfulness-Based Stress Reduction (MBSR). The authors implemented MBSR as an optional course for residents and qualitatively explored how it influenced residents professionally...
April 24, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29685112/a-randomized-controlled-trial-testing-a-social-network-intervention-to-promote-physical-activity-among-adolescents
#7
Thabo J van Woudenberg, Kirsten E Bevelander, William J Burk, Crystal R Smit, Laura Buijs, Moniek Buijzen
BACKGROUND: The current study examined the effectiveness of a social network intervention to promote physical activity among adolescents. Social network interventions utilize peer influence to change behavior by identifying the most influential individuals within social networks (i.e., influence agents), and training them to promote the target behavior. METHOD: A total of 190 adolescents (46.32% boys; M age = 12.17, age range: 11-14 years) were randomly allocated to either the intervention or control condition...
April 23, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29651316/early-identification-of-patients-in-need-of-palliative-care-in-slovenian-general-practice
#8
Lisette Klok, Yvonne Engels, Carel Veldhoven, Danica Rotar Pavlič
Background: To help general practitioners (GPs) in early identification of patients with palliative care (PC) needs, this pilot study aimed to determine the potential of the combined original surprise question (SQ1) ('Would I be surprised if this patient died within the next 12 months?') and the second surprise question (SQ2) ('Would I be surprised if this patient was still alive after 12 months?'). We hypothesized that answering these SQs would trigger them to make a multidimensional care plan...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29624536/working-memory-training-following-neonatal-critical-illness-a-randomized-controlled-trial
#9
Raisa M Schiller, Marlous J Madderom, Joost van Rosmalen, Arno F J van Heijst, Ivo de Blaauw, Elisabeth Utens, André B Rietman, Frank Verhulst, Dick Tibboel, Tonya White, Hanneke IJsselstijn
OBJECTIVES: To test the immediate and long-term effectiveness of Cogmed Working Memory Training following extracorporeal membrane oxygenation and/or congenital diaphragmatic hernia. DESIGN: A nationwide randomized controlled trial assessing neuropsychologic outcome immediately and 1 year post Cogmed Working Memory Training, conducted between October 2014 and June 2017. Researchers involved in the follow-up assessments were blinded to group allocation. SETTING: Erasmus MC-Sophia Children's Hospital, Rotterdam, and Radboud University Medical Center, Nijmegen, the Netherlands...
April 5, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29615411/acpa-igg-galactosylation-associates-with-disease-activity-in-pregnant-patients-with-rheumatoid-arthritis
#10
Albert Bondt, Lise Hafkenscheid, David Falck, T Martijn Kuijper, Yoann Rombouts, Johanna M W Hazes, Manfred Wuhrer, Radboud J E M Dolhain
OBJECTIVES: Patients with autoantibody-positive rheumatoid arthritis (RA) are less likely to experience pregnancy-induced improvement of RA disease activity (DAS28-C reactive protein (CRP)) compared with patients with autoantibody-negative RA. Anti-citrullinated protein antibodies (ACPAs) are the most specific autoantibodies for RA. We previously demonstrated that disease improvement is associated with changes in total IgG glycosylation, which regulate antibody effector function. Therefore, we sought to analyse the ACPA-IgG glycosylation profile during pregnancy with the aim to understand the lower change of pregnancy-induced improvement of the disease in patients with autoantibody-positive RA...
April 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29540613/plasma-a%C3%AE-amyloid-%C3%AE-levels-and-severity-and-progression-of-small-vessel-disease
#11
Esther M C van Leijsen, H Bea Kuiperij, Iris Kersten, Mayra I Bergkamp, Ingeborg W M van Uden, Hugo Vanderstichele, Erik Stoops, Jurgen A H R Claassen, Ewoud J van Dijk, Frank-Erik de Leeuw, Marcel M Verbeek
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is a frequent pathology in aging and contributor to the development of dementia. Plasma Aβ (amyloid β) levels may be useful as early biomarker, but the role of plasma Aβ in SVD remains to be elucidated. We investigated the association of plasma Aβ levels with severity and progression of SVD markers. METHODS: We studied 487 participants from the RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort) of whom 258 participants underwent 3 MRI assessments during 9 years...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29495023/a-guide-to-managing-tooth-wear-the-radboud-philosophy
#12
B Loomans, N Opdam
This paper explains a conservative, pragmatic and minimally invasive intervention concept for the treatment of severe tooth wear patients based on the Radboud Tooth Wear Project in the Netherlands. Guidelines and flowcharts for management of severe tooth wear patients and rehabilitation in increased vertical dimension of occlusion are presented. We concluded that: (a) Restorative treatment is not always indicated, even for patients with severe tooth wear. (b) If the patient has no complaints, counselling and monitoring is probably the best option...
March 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29461957/disease-activity-and-dropout-in-young-persons-with-juvenile-idiopathic-arthritis-in-transition-of-care-a-longitudinal-observational-study
#13
Philomine A van Pelt, Radboud J E M Dolhain, Aike A Kruize, Judy J W Ammerlaan, Johanna W Hazes, Johannes W J Bijlsma, Nico M Wulffraat
OBJECTIVES: Reaching a certain age, juvenile idiopathic arthritis (JIA) patients in paediatric care are transferred to adult care. An increased disease activity after transfer and increased dropout has been suggested, however, evidence is scarce. Our aim is to determine whether the process of transition is associated with increased disease-activity and dropout, and to identify associated factors. METHODS: During a 3-year prospective transition cohort study, paediatric patients (14-17yrs) were transferred to adult care...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29437488/a-stepwise-procedure-to-define-a-data-collection-framework-for-a-clinical-biobank
#14
Peggy Manders, Tessa M A Peters, Ariaan E Siezen, Iris A L M van Rooij, Roger Snijder, Dorine W Swinkels, Gerhard A Zielhuis
INTRODUCTION: Current guidelines for clinical biobanking have a strong focus on obtaining, handling, and storage of biospecimens. However, to allow for research tying biomarker analysis to clinical decision making, there should be more focus on collection of data on donor characteristics. Therefore, our aim was to develop a stepwise procedure to define a framework as a tool to help start the data collection process in clinical biobanking. MATERIALS AND METHODS: The Radboud Biobank (RB) is a central clinical biobanking facility designed in accordance with the standards set by the Parelsnoer Institute, a Dutch national biobank originally initiated with eight different disease cohorts...
April 2018: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29395996/cerebral-tryptophan-metabolism-and-outcome-of-tuberculous-meningitis-an-observational-cohort-study
#15
Arjan van Laarhoven, Sofiati Dian, Raúl Aguirre-Gamboa, Julian Avila-Pacheco, Isis Ricaño-Ponce, Carolien Ruesen, Jessi Annisa, Valerie A C M Koeken, Lidya Chaidir, Yang Li, Tri Hanggono Achmad, Leo A B Joosten, Richard A Notebaart, Rovina Ruslami, Mihai G Netea, Marcel M Verbeek, Bachti Alisjahbana, Vinod Kumar, Clary B Clish, A Rizal Ganiem, Reinout van Crevel
BACKGROUND: Immunopathology contributes to the high mortality of tuberculous meningitis, but the biological pathways involved are mostly unknown. We aimed to compare cerebrospinal fluid (CSF) and serum metabolomes of patients with tuberculous meningitis with that of controls without tuberculous meningitis, and assess the link between metabolite concentrations and mortality. METHODS: In this observational cohort study at the Hasan Sadikin Hospital (Bandung, Indonesia) we measured 425 metabolites using liquid chromatography-mass spectrometry in CSF and serum from 33 HIV-negative Indonesian patients with confirmed or probable tuberculous meningitis and 22 control participants with complete clinical data between March 12, 2009, and Oct 27, 2013...
May 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29393211/the-radboud-dysarthria-assessment-development-and-clinimetric-evaluation
#16
Simone Knuijt, Johanna G Kalf, Baziel G M van Engelen, Bert J M de Swart, Alexander C H Geurts
OBJECTIVE: In the absence of an adequate dysarthria assessment in the Netherlands, we developed the Radboud Dysarthria Assessment (RDA). This article describes its development and clinimetric evaluation. PATIENTS AND METHODS: Forty-three patients were assessed with the RDA. The recording forms were subjected to exploratory factor analysis and estimation of internal consistency. The self-evaluation questionnaire was tested for internal consistency and the severity scale for intra- and inter-rater reliability...
2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29349543/saving-robots-improves-laparoscopic-performance-transfer-of-skills-from-a-serious-game-to-a-virtual-reality-simulator
#17
Wouter M IJgosse, Harry van Goor, Jan-Maarten Luursema
BACKGROUND: Residents find it hard to commit to structural laparoscopic skills training. Serious gaming has been proposed as a solution on the premise that it is effective and more motivating than traditional simulation. We establish construct validity for the laparoscopic serious game Underground by comparing laparoscopic simulator performance for a control group and an Underground training group. METHODS: A four-session laparoscopic basic skills course is part of the medical master students surgical internship at the Radboud University Medical Centre...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29314143/modeling-poliovirus-transmission-in-pakistan-and-afghanistan-to-inform-vaccination-strategies-in-undervaccinated-subpopulations
#18
Radboud J Duintjer Tebbens, Mark A Pallansch, Stephen L Cochi, Derek T Ehrhardt, Noha H Farag, Stephen C Hadler, Lee M Hampton, Maureen Martinez, Steve G F Wassilak, Kimberly M Thompson
Due to security, access, and programmatic challenges in areas of Pakistan and Afghanistan, both countries continue to sustain indigenous wild poliovirus (WPV) transmission and threaten the success of global polio eradication and oral poliovirus vaccine (OPV) cessation. We fitted an existing differential-equation-based poliovirus transmission and OPV evolution model to Pakistan and Afghanistan using four subpopulations to characterize the well-vaccinated and undervaccinated subpopulations in each country. We explored retrospective and prospective scenarios for using inactivated poliovirus vaccine (IPV) in routine immunization or supplemental immunization activities (SIAs)...
January 3, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29240310/diagnostic-accuracy-of-high-resolution-t2-weighted-mri-vs-contrast-enhanced-t1-weighted-mri-to-screen-for-cerebellopontine-angle-lesions-in-symptomatic-patients
#19
M A Hentschel, H P M Kunst, M M Rovers, S C A Steens
OBJECTIVE: To evaluate diagnostic accuracy of high-resolution T2-weighted MRI (T2w) for detecting cerebellopontine angle (CPA) lesions compared to a combined protocol including gadolinium enhanced T1-weighted MRI (GdT1w). SETTING: Department of Radiology & Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. PARTICIPANTS: A random sample of MRIs from 350 patients (700 CPAs) with asymmetrical audiovestibular complaints was used, acquired between 2013 and 2016...
December 14, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29218587/facial-expression-analysis-with-affdex-and-facet-a-validation-study
#20
Sabrina Stöckli, Michael Schulte-Mecklenbeck, Stefan Borer, Andrea C Samson
The goal of this study was to validate AFFDEX and FACET, two algorithms classifying emotions from facial expressions, in iMotions's software suite. In Study 1, pictures of standardized emotional facial expressions from three databases, the Warsaw Set of Emotional Facial Expression Pictures (WSEFEP), the Amsterdam Dynamic Facial Expression Set (ADFES), and the Radboud Faces Database (RaFD), were classified with both modules. Accuracy (Matching Scores) was computed to assess and compare the classification quality...
December 7, 2017: Behavior Research Methods
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