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https://www.readbyqxmd.com/read/29138206/monitor-ic-study-a-mixed-methods-prospective-multicentre-controlled-cohort-study-assessing-5-year-outcomes-of-icu-survivors-and-related-healthcare-costs-a-study-protocol
#1
Wytske Geense, Marieke Zegers, Hester Vermeulen, Mark van den Boogaard, Johannes van der Hoeven
INTRODUCTION: Due to advances in critical care medicine, more patients survive their critical illness. However, intensive care unit (ICU) survivors often experience long-term physical, cognitive and mental problems, summarised as post-intensive care syndrome (PICS), impacting their health-related quality of life (HRQoL). In what frequency PICS occurs, and to what extent this influences ICU survivors' HRQoL, is mostly unknown. The aims of this study are therefore to study the: (1) 5-year patient outcomes, (2) predictors for PICS, (3) ratio between HRQoL of ICU survivors and healthcare-related costs, and (4) care and support needs...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29115764/development-of-a-clinical-transition-pathway-for-adolescents-in-the-netherlands
#2
Margot Walter, Johanna Mw Hazes, Radboud Jem Dolhain, Philomine van Pelt, Annette van Dijk, Sylvia Kamphuis
AIMS: To explore how young people with juvenile-onset rheumatic and musculoskeletal diseases (jRMDs) and their parent(s) experience care during preparation for the upcoming transfer to adult services, and to develop a clinical transition pathway. METHOD: A survey was conducted with 32 young people aged between 14 and 20 years with jRMDs, and their parents ( n =33), treated at the department of paediatric rheumatology in a tertiary care children's hospital in the Netherlands...
November 7, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29106598/safety-and-effectiveness-of-restrictive-eculizumab-treatment-in-atypical-haemolytic-uremic-syndrome
#3
Kioa L Wijnsma, Caroline Duineveld, Elena B Volokhina, Lambertus P van den Heuvel, Nicole C A J van de Kar, Jack F M Wetzels
Background: Atypical haemolytic uremic syndrome (aHUS) is a rare but severe form of thrombotic microangiopathy as a consequence of complement dysregulation. aHUS has a poor outcome with high mortality and >50% of patients developing end-stage renal disease. Since the end of 2012, these outcomes have greatly improved with the introduction of eculizumab. Currently the duration of treatment is debated. Most guidelines advise lifelong treatment. However, there is no hard evidence to support this advice...
July 4, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29067548/operating-room-waste-disposable-supply-utilization-in-neurointerventional-procedures
#4
Luigi Rigante, Walid Moudrous, Joost de Vries, André J Grotenhuis, Hieronymus D Boogaarts
BACKGROUND: Operating rooms account for 70% of hospital waste, increasing healthcare costs and creating environmental hazards. Endovascular treatment of cerebrovascular pathologies has become prominent, and associated products highly impact the total cost of care. We investigated the costs of endovascular surgical waste at our institution. METHODS: Data from 53 consecutive endovascular procedures at the Radboud UMC Nijmegen from May to December 2016 were collected...
October 25, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29040646/statins-affect-skeletal-muscle-performance-evidence-for-disturbances-in-energy-metabolism
#5
Neeltje A E Allard, Tom J J Schirris, Rebecca J Verheggen, Frans G M Russel, Richard J Rodenburg, Jan A M Smeitink, Paul D Thompson, Maria T E Hopman, Silvie Timmers
Context: Statin myopathy is linked to disturbances in mitochondrial function and exercise intolerance. Objectives: To determine whether differences exist in exercise performance, muscle function and mitochondrial oxidative capacity and content between symptomatic and asymptomatic statin users, and non-statin using controls. Design: Cross-sectional study. Setting: Department of Physiology of the Radboud University Medical Center...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29037467/cross-cultural-adaptation-and-refinement-of-an-english-version-of-a-dutch-patient-reported-questionnaire-for-hand-sensitivity-the-radboud-evaluation-of-sensitivity
#6
Tara L Packham, Joy C MacDermid, Susan Michlovitz, Edith Cup, Lucelle Van de Ven-Stevens
STUDY DESIGN: Longitudinal clinical measurement. INTRODUCTION: Sensory alterations in the hand can present as both decreased sensation or numbness, and hyperesthesia, including mechanical allodynia and cold intolerance. However, few patient-reported outcomes have been developed and validated for evaluation, particularly for increased sensitivity. The Radboud Evaluation of Sensitivity was developed in the Netherlands for patient-reported evaluation of hand sensitivity in complex regional pain syndrome...
October 13, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29036369/referral-of-patients-with-fever-of-unknown-origin-to-an-expertise-center-has-high-diagnostic-and-therapeutic-value
#7
Catharina M Mulders-Manders, Gianni Pietersz, Anna Simon, Chantal P Bleeker-Rovers
Background: up to 50% of patients with fever of unknown origin (FUO) remain undiagnosed despite extensive evaluation. In expertise centers, at least 25-63% of these patients is referred after evaluation in another hospital. The diagnostic and therapeutic yields of referral to an expertise center are currently unknown. Aim: To determine the diagnostic and therapeutic yield of referral of patients with fever of unknown origin (FUO) that remain undiagnosed in non-expertise hospitals...
July 28, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28989549/the-effectiveness-of-mindfulness-based-stress-reduction-on-psychological-distress-and-cognitive-functioning-in-patients-with-multiple-sclerosis-a-pilot-study
#8
Roos J Blankespoor, Melanie P J Schellekens, Sandra H Vos, Anne E M Speckens, Brigit A de Jong
Patients with multiple sclerosis (MS) often suffer from psychological distress and cognitive dysfunctioning. These factors negatively impact the health-related quality of life. Only recently behavioral therapeutic approaches are being used to treat psychological distress in MS. The aim of the present pilot study was not only to investigate the effectiveness of mindfulness-based stress reduction (MBSR) on psychological distress but also to explore whether it can improve cognitive functioning among patients with MS...
2017: Mindfulness
https://www.readbyqxmd.com/read/28949263/reference-values-of-maximum-performance-tests-of-speech-production
#9
Simone Knuijt, Johanna Kalf, Baziel Van Engelen, Alexander Geurts, Bert de Swart
PURPOSE: Maximum performance tests examine upper limits of speech motor performance, as used by speech-language pathologists in dysarthria assessment protocols. The Radboud Dysarthria Assessment includes maximum repetition rate, maximum phonation time, fundamental frequency range and maximum phonation volume to assist in detecting pathological performance. This study aims to obtain reference values for each of these tests. METHOD: A group of 224 healthy Dutch adults aged 18-80 years performed the maximum performance tests...
September 26, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28882923/-reframing-healthcare-services-through-the-lens-of-co-production-rhelaunch-a-study-protocol-for-a-mixed-methods-evaluation-of-mechanisms-by-which-healthcare-and-social-services-impact-the-health-and-well-being-of-patients-with-copd-and-chf-in-the-usa-and-the
#10
Gijs Hesselink, Julie Johnson, Paul Batalden, Michelle Carlson, Wytske Geense, Stef Groenewoud, Sylvester Jones, Brita Roy, Christina Sansone, Judith R L M Wolf, Bradley Bart, Hub Wollersheim
INTRODUCTION: The USA lags behind other high-income countries in many health indicators. Outcome differences are associated with differences in the relative spending between healthcare and social services at the national level. The impact of the ratio and delivery of social and healthcare services on the individual patient's health is however unknown. 'Reframing Healthcare Services through the Lens of Co-Production' (RheLaunCh) will be a cross-Atlantic comparative study of the mechanisms by which healthcare and social service delivery may impact patient health with chronic conditions...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28878046/nonlinear-temporal-dynamics-of-cerebral-small-vessel-disease-the-run-dmc-study
#11
Esther M C van Leijsen, Ingeborg W M van Uden, Mohsen Ghafoorian, Mayra I Bergkamp, Valerie Lohner, Eline C M Kooijmans, Helena M van der Holst, Anil M Tuladhar, David G Norris, Ewoud J van Dijk, Loes C A Rutten-Jacobs, Bram Platel, Catharina J M Klijn, Frank-Erik de Leeuw
OBJECTIVE: To investigate the temporal dynamics of cerebral small vessel disease (SVD) by 3 consecutive assessments over a period of 9 years, distinguishing progression from regression. METHODS: Changes in SVD markers of 276 participants of the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) cohort were assessed at 3 time points over 9 years. We assessed white matter hyperintensities (WMH) volume by semiautomatic segmentation and rated lacunes and microbleeds manually...
October 10, 2017: Neurology
https://www.readbyqxmd.com/read/28838198/lessons-from-globally-coordinated-cessation-of-serotype-2-oral-poliovirus-vaccine-for-the-remaining-serotypes
#12
Kimberly M Thompson, Radboud J Duintjer Tebbens
Background: Comparing model expectations with the experience of oral poliovirus vaccine (OPV) containing serotype 2 (OPV2) cessation can inform risk management for the expected cessation of OPV containing serotypes 1 and 3 (OPV13). Methods: We compare the expected post-OPV2-cessation OPV2-related viruses from models with the evidence available approximately 6 months after OPV2 cessation. We also model the trade-offs of use vs nonuse of monovalent OPV (mOPV) for outbreak response considering all 3 serotypes...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838194/lessons-from-the-polio-endgame-overcoming-the-failure-to-vaccinate-and-the-role-of-subpopulations-in-maintaining-transmission
#13
Kimberly M Thompson, Radboud J Duintjer Tebbens
Background: Recent detections of circulating serotype 2 vaccine-derived poliovirus in northern Nigeria (Borno and Sokoto states) and Pakistan (Balochistan Province) and serotype 1 wild poliovirus in Pakistan, Afghanistan, and Nigeria (Borno) represent public health emergencies that require aggressive response. Methods: We demonstrate the importance of undervaccinated subpopulations, using an existing dynamic poliovirus transmission and oral poliovirus vaccine evolution model...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28814852/prognostic-variables-and-scores-identifying-the-end-of-life-in-copd-a-systematic-review
#14
REVIEW
Laura-Jane E Smith, Elizabeth Moore, Ifrah Ali, Liam Smeeth, Patrick Stone, Jennifer K Quint
INTRODUCTION: COPD is a major cause of mortality, and the unpredictable trajectory of the disease can bring challenges to end-of-life care. We aimed to investigate known prognostic variables and scores that predict prognosis in COPD in a systematic literature review, specifically including variables that contribute to risk assessment of patients for death within 12 months. METHODS: We conducted a systematic review on prognostic variables, multivariate score or models for COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814432/minimal-to-no-transfer-of-certolizumab-pegol-into-breast-milk-results-from-cradle-a-prospective-postmarketing-multicentre-pharmacokinetic-study
#15
MULTICENTER STUDY
Megan Eb Clowse, Frauke Förger, Caroline Hwang, John Thorp, Radboud Jem Dolhain, Astrid van Tubergen, Laura Shaughnessy, Jeff Simpson, Marie Teil, Nathalie Toublanc, Maggie Wang, Thomas W Hale
BACKGROUND: Women with chronic inflammatory diseases face uncertainty regarding the safety of biologics during breast feeding. CRADLE was the first industry-sponsored study to evaluate certolizumab pegol (CZP) concentrations in human breast milk and estimate average daily infant dose (ADID) of maternal CZP. METHODS: CRADLE (NCT02154425) was a pharmacokinetic study of lactating mothers receiving CZP. After ≥3 CZP doses, breast milk samples were collected across one dosing period (14 days for 200 mg every 2 weeks [Q2W]; 28 days for 400 mg every 4 weeks [Q4W])...
November 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28738319/meeting-report-intercellular-interactions-in-context-towards-a-mechanistic-understanding-of-cells-in-organs
#16
David Bryant, Aaron Johnson
The Company of Biologists held the workshop 'Intercellular interactions in context: towards a mechanistic understanding of cells in organs' at historic Wiston House in West Sussex, UK, 5-8 February 2017. The meeting brought together around 30 scientists from disparate backgrounds - yet with a common interest of how tissue morphogenesis occurs and its dysregulation leads to pathologies - to intensively discuss their latest research, the current state of the field, as well as any challenges for the future. This report summarises the concepts and challenges that arose as key questions for the fields of cell, cancer and developmental biology...
July 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28696580/empowerment-in-adolescents-and-young-adults-with-cancer-relationship-with-health-related-quality-of-life
#17
Suzanne E J Kaal, Olga Husson, Saskia van Duivenboden, Rosemarie Jansen, Eveliene Manten-Horst, Petra Servaes, Judith B Prins, Sanne W van den Berg, Winette T A van der Graaf
BACKGROUND: The difficulties adolescents and young adults (AYAs) encounter during a cancer experience may result in a reduction in or absence of empowerment. The aims of the current study were to assess levels of empowerment and associated (demographic, clinical, or psychological) factors and examine the association between empowerment and health-related quality of life (HRQOL) among AYA patients with cancer. METHODS: Patients aged 18 to 35 years at time of cancer diagnosis and who were seen by 1 of the members of the specialized multidisciplinary AYA team of the Radboud University Medical Center were invited to complete questionnaires regarding empowerment; HRQOL; and sociodemographic, clinical, and psychological characteristics (autonomy, coping, unmet social support needs, and psychological distress)...
October 15, 2017: Cancer
https://www.readbyqxmd.com/read/28687986/insights-from-a-systematic-search-for-information-on-designs-costs-and-effectiveness-of-poliovirus-environmental-surveillance-systems
#18
REVIEW
Radboud J Duintjer Tebbens, Marita Zimmermann, Mark A Pallansch, Kimberly M Thompson
Poliovirus surveillance plays a critical role in achieving and certifying eradication and will play a key role in the polio endgame. Environmental surveillance can provide an opportunity to detect circulating polioviruses prior to the observation of any acute flaccid paralysis cases. We completed a systematic review of peer-reviewed publications on environmental surveillance for polio including the search terms "environmental surveillance" or "sewage," and "polio," "poliovirus," or "poliomyelitis," and compared characteristics of the resulting studies...
December 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28679431/iga-n-and-o-glycosylation-profiling-reveals-no-association-with-the-pregnancy-related-improvement-in-rheumatoid-arthritis
#19
Albert Bondt, Simone Nicolardi, Bas C Jansen, T Martijn Kuijper, Johanna M W Hazes, Yuri E M van der Burgt, Manfred Wuhrer, Radboud J E M Dolhain
BACKGROUND: The Fc glycosylation of immunoglobulin G (IgG) is well known to associate with rheumatoid arthritis (RA) disease activity. The same may be true for other classes of Igs. In the present study, we sought to determine whether the glycosylation of IgA was different between healthy subjects and patients with RA, as well as whether it was associated with RA disease activity, in particular with the pregnancy-associated improvement thereof or the flare after delivery. METHODS: A recently developed high-throughput method for glycoprofiling of IgA1 was applied to affinity-captured IgA from sera of patients with RA (n = 252) and healthy control subjects (n = 32) collected before, during and after pregnancy...
July 5, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28629318/the-effect-of-a-daily-application-of-a-0-05-chlorhexidine-oral-rinse-solution-on-the-incidence-of-aspiration-pneumonia-in-nursing-home-residents-a-multicenter-study
#20
Vanessa R Y Hollaar, Gert-Jan van der Putten, Claar D van der Maarel-Wierink, Ewald M Bronkhorst, Bert J M de Swart, Nico H J Creugers
BACKGROUND: Dysphagia and potential respiratory pathogens in the oral biofilm are risk factors for aspiration pneumonia in nursing home residents. The aim of the study was to examine if the daily application of 0.05% chlorhexidine oral rinse solution is effective in reducing the incidence of aspiration pneumonia in nursing home residents with dysphagia. Associations between background variables (age, gender, dysphagia severity, care dependency, medication use, number of medical diagnoses, teeth and dental implants, and wearing removable dentures) and the incidence of aspiration pneumonia were also examined...
June 19, 2017: BMC Geriatrics
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