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https://www.readbyqxmd.com/read/29782944/a-comprehensive-review-on-contact-lens-for-ophthalmic-drug-delivery
#1
REVIEW
Jiawen Xu, Yingyan Xue, Gaoyong Hu, Tianyu Lin, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang
With the prevalence of electronic devices and an aging population, the number of people affected with eye disease is increasing year by year. In spite of a large number of eye drops on the market, most of them do not perform sufficiently, due to rapid clearance mechanisms and ocular barriers. To enhance drug delivery to the eye, a number of novel formulations for ocular diseases have been investigated over recent decades, aiming to increase drug retention and permeation while also allowing for sustained drug release over prolonged periods...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29782814/primary-assessment-of-the-patient-with-orbital-fractures-should-include-pupillary-response-and-visual-acuity-changes-to-detect-occult-major-ocular-injuries
#2
Jeffrey Chow, Krishnan Parthasarathi, Patrick Mehanna, Eline Whist
PURPOSE: Sight-threatening injuries associated with orbital fractures are of major concern to maxillofacial surgeons whom are often the first asked to assess these patients. Eliciting signs and symptoms that are predictive of these injuries would allow expedited ophthalmic consultation and appropriate management. We hypothesized that abnormal pupillary response is predictive of major ocular injuries. PATIENTS AND METHODS: A retrospective cohort study of patients with facial fractures was instituted with review of all associated ophthalmic injuries...
May 1, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29782636/a-boxplot-for-circular-data
#3
Davide Buttarazzi, Giuseppe Pandolfo, Giovanni C Porzio
The box-and-whiskers plot is an extraordinary graphical tool that provides a quick visual summary of an observed distribution. In spite of its many extensions, a really suitable boxplot to display circular data is not yet available. Thanks to its simplicity and strong visual impact, such a tool would be especially useful in all fields where circular measures arise: biometrics, astronomy, environmetrics, Earth sciences, to cite just a few. For this reason, in line with Tukey's original idea, a Tukey-like circular boxplot is introduced...
May 21, 2018: Biometrics
https://www.readbyqxmd.com/read/29782582/surfaces-from-the-visual-past-recovering-high-resolution-terrain-data-from-historic-aerial-imagery-for-multitemporal-landscape-analysis
#4
Christopher Sevara, Geert Verhoeven, Michael Doneus, Erich Draganits
Historic aerial images are invaluable sources of aid to archaeological research. Often collected with large-format photogrammetric quality cameras, these images are potential archives of multidimensional data that can be used to recover information about historic landscapes that have been lost to modern development. However, a lack of camera information for many historic images coupled with physical degradation of their media has often made it difficult to compute geometrically rigorous 3D content from such imagery...
2018: Journal of archaeological method and theory
https://www.readbyqxmd.com/read/29782020/whole-mount-immunofluorescence-and-follicle-quantification-of-cultured-mouse-ovaries
#5
Vera D Rinaldi, Jordana C Bloom, John C Schimenti
Research in the field of mammalian reproductive biology often involves evaluating the overall health of ovaries and testes. Specifically, in females, ovarian fitness is often assessed by visualizing and quantifying follicles and oocytes. Because the ovary is an opaque three-dimensional tissue, traditional approaches require laboriously slicing the tissue into numerous serial sections in order to visualize cells throughout the entire organ. Furthermore, because quantification by this method typically entails scoring only a subset of the sections separated by the approximate diameter of an oocyte, it is prone to inaccuracy...
May 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781999/preparation-of-murine-submandibular-salivary-gland-for-upright-intravital-microscopy
#6
Xenia Ficht, Flavian Thelen, Bettina Stolp, Jens V Stein
The submandibular salivary gland (SMG) is one of the three major salivary glands, and is of interest for many different fields of biological research, including cell biology, oncology, dentistry, and immunology. The SMG is an exocrine gland comprised of secretory epithelial cells, myofibroblasts, endothelial cells, nerves, and extracellular matrix. Dynamic cellular processes in the rat and mouse SMG have previously been imaged, mostly using inverted multi-photon microscope systems. Here, we describe a straightforward protocol for the surgical preparation and stabilization of the murine SMG in anesthetized mice for in vivo imaging with upright multi-photon microscope systems...
May 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781873/case-report-use-of-sports-and-performance-vision-training-to-benefit-a-low-vision-patient-s-function
#7
Daniel M Laby
SIGNIFICANCE: Despite our inability to attenuate the course of many ocular diseases that can ultimately lead to loss or significantly decreased visual function, this report describes a potential technique to aid such patients in maximizing the use of the vision that remains. PURPOSE: The aim of this study was to demonstrate the applicability of utilizing sports vision training to improve objective and subjective visuomotor function in a low-vision patient. CASE REPORT: A 37-year-old woman with Usher syndrome presented with reduced central visual acuity and visual field...
May 17, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29781835/deep-learning-classifier-with-an-ultra-wide-field-scanning-laser-ophthalmoscope-detects-glaucoma-visual-field-severity
#8
Masumoto Hiroki, Hitoshi Tabuchi, Shunsuke Nakakura, Ishitobi Naofumi, Masayuki Miki, Enno Hiroki
PURPOSE: To evaluate the accuracy of detecting glaucoma visual field defect severity using deep-learning classifier (DL) with an ultra-wide-field scanning laser ophthalmoscope. METHODS: One eye of 982 open angle glaucoma (OAG) patients and 417 healthy eyes were enrolled. We categorized glaucoma patients into three groups according to the glaucoma visual field damage (Humphrey Field Analyzer 24-2 program) (early; -6▒dB (mean deviation) or better, moderate; between -6 and -12▒dB, and severe as mean deviation of -12▒dB or worse)...
May 17, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29781618/field-detection-of-citrus-huanglongbing-associated-with-candidatus-liberibacter-asiaticus-by-recombinese-polymerase-amplification-within-15-min
#9
Wenjuan Qian, Ying Lu, Youqing Meng, Zunzhong Ye, Liu Wang, Rui Wang, Qiqi Zheng, Jian Wu
Candidatus Liberibacter asiaticus(Las)is the most prevalent bacterium associated with Huanglongbing which is one of the most destructive diseases of citrus. In this paper, an extremely rapid and simple method for field detection of Las from leaf samples based on recombinase polymerase amplification (RPA) is developed. Three RPA primer pairs were designed and evaluated. RPA amplification was optimized so that it could be accomplished within 10 min. In combination with DNA crude extraction by 50-fold diluting after 1 min of grinding in 0...
May 21, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29780957/optic-nerve-compression-as-a-late-complication-of-a-hydrogel-explant-with-silicone-encircling-band
#10
Niels Crama, Leo Kluijtmans, B Jeroen Klevering
Purpose: To present a complication of compressive optic neuropathy caused by a swollen hydrogel explant and posteriorly displaced silicone encircling band. Observations: A 72-year-old female patient presented with progressive visual loss and a tilted optic disc. Her medical history included a retinal detachment in 1993 that was treated with a hydrogel explant under a solid silicone encircling band. Visual acuity had decreased from 6/10 to 6/20 and perimetry showed a scotoma in the temporal superior quadrant...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780940/colored-floaters-as-a-manifestation-of-digoxin-toxicity
#11
Lynn Shi, Linus D Sun, Jeffrey G Odel
Purpose: Since its report in one patient more than 70 years ago, digitalis-induced colored muscae volitantes have not surfaced again in the literature. We report here a case of digoxin induced colored floaters. Observations: An 89-year-old man on 0.25 mg digoxin daily developed visual hallucinations and colored floaters. He had floaters in the past but now they were in various colors including yellow, green, blue and red, though predominantly in yellow. These "weirdly" shaped little particles wiggled around as if in a viscous solution and casted shadows in his vision...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780918/bariatric-surgery-and-its-impact-on-pseudotumor-cerebri-a-case-report
#12
Norberto Mancera, Michel M Murr, Mitchell Drucker
Purpose: Pseudotumor cerebri is a debilitating condition that causes severe headaches and progressive visual field loss. In this report, we present a patient with Class III obesity, with pseudotumor cerebri who failed medical management and attempted weight loss via diet and exercise. Observations: After undergoing bariatric surgery, the patient had significant weight loss and improvement of visual field defects. Conclusion and importance: These results suggest that bariatric surgery may be an effective option for patients with rapidly progressing visual loss due to pseudotumor cerebri...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780917/advanced-pigment-dispersion-glaucoma-secondary-to-phakic-intraocular-collamer-lens-implant
#13
Clara Ye, Cajal K Patel, Anna C Momont, Yao Liu
Purpose: We report a case of pigment dispersion glaucoma secondary to uncomplicated phakic intraocular collamer lens (ICL) (Visian ICL™, Staar Inc., Monrovia, CA) implant that resulted in advanced visual field loss. Observations: A 50-year-old man presented for routine follow-up status post bilateral phakic intraocular collamer lens (ICL) placement 8 years earlier. He was incidentally found to have a decline in visual acuity from an anterior subcapsular cataract and elevated intraocular pressure (IOP) in the left eye...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780904/benign-yellow-dot-maculopathy
#14
Elad Moisseiev
Purpose: To describe a new family with benign yellow dot maculopathy. Observations: A young male patient was found to have bilateral multiple small yellow dots in both maculae. Visual acuity and color vision were normal, and no pathological findings were demonstrated on automated visual field, optical coherence tomography (OCT) and electrophysiological testing. Examination of his parents revealed similar findings in his mother, suggesting autosomal dominant inheritance...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780600/fluoroscopic-gastric-peroral-endoscopic-pyloromyotomy-g-poem-in-patients-with-a-failed-gastric-electrical-stimulator
#15
Abhinav Koul, Sunil Dacha, Parit Mekaroonkamol, Xiaoyu Li, Lianyong Li, Nikrad Shahnavaz, Steven Keilin, Field F Willingham, Jennifer Christie, Qiang Cai
Background: Gastric electrical stimulators (GESs) have been used to treat refractory gastroparesis in patients who fail initial therapies such as dietary modifications, control of psychological stressors and pharmacologic treatment. More recently, gastric peroral endoscopic pyloromyotomy (G-POEM) has emerged as a novel endoscopic technique to treat refractory gastroparesis. We present a case series of patients with refractory gastroparesis who failed treatment with an implanted GES that were safely treated with G-POEM performed under fluoroscopy as a salvage therapy...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29780438/magnetic-domain-patterns-in-bilayered-ribbons-studied-by-magnetic-force-microscopy-and-magneto-optical-kerr-microscopy
#16
Jana Trojková, Ondřej Životský, Aleš Hendrych, Dmitry Markov, Klára Drobíková
The magnetic domain patterns of amorphous bilayered FeSiB/FeNbSiB and FeNbCuSiB/CoSiB ribbons are observed and analysed using the magneto-optical Kerr microscopy (MOKM) and magnetic force microscopy (MFM). Both microscopic techniques are highly sensitive to the sample surface; possibility of Kerr microscopy to visualize the domains separately in both layers is achieved by focusing the laser spot on the ribbon cross section. Wide curved domains as well as fine fingerprint domains were detected at the surface of ribbons due to presence of local stresses coming from the preparation process...
2018: Scanning
https://www.readbyqxmd.com/read/29780060/development-of-oropharyngeal-scope-type-ii-with-integrated-tongue-depressor-for-examination-of-the-oropharynx-ntop2016-study
#17
Koichi Tsunoda, Rika Kobayashi, Akiko Kada, Akiko M Saito, Y U Hanada, Hayato Misawa, Keizo Horibe, Tonghyo Chong, Miwako Honda, Yoko Morita, Osamu Komiyama
The oropharynx is examined by focusing an electric light, penlight, or forehead mirror on a desired visual field using a tongue depressor. However, it is extremely difficult to obtain objective recorded evidence for display with these methods, and the tools for examination have remained virtually unchanged for the past century. Treatment of the pharynx/oral cavity is exceedingly difficult, particularly in elderly patients and children. Therefore, there is an increasing need to develop a method for displaying the visual field during oropharyngeal examinations which is acceptable to patients, which can easily be applied at all medical institutions, which can be displayed to third parties, and which can be used by doctors for recording data and determining treatment...
May 21, 2018: Kurume Medical Journal
https://www.readbyqxmd.com/read/29779933/-hereditary-optic-neuropathies-in-pediatric-ophthalmology
#18
C Orssaud, M P Robert, D Bremond Gignac
INTRODUCTION: Hereditary optic neuropathies (HON) often begin in adulthood. However, some of them can have an early onset. These may have specific clinical features and natural histories. PATIENTS AND METHODS: Retrospective study of HON patients with onset before the age of 14 years seen in a referral center. In addition to the age of onset, we evaluated the genetic etiology, visual acuity at 15 years, last best corrected visual acuity, optic disc appearance, visual field and extra-ophthalmological manifestations...
May 17, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29779878/a-role-for-mouse-primary-visual-cortex-in-motion-perception
#19
Tiago Marques, Mathew T Summers, Gabriela Fioreze, Marina Fridman, Rodrigo F Dias, Marla B Feller, Leopoldo Petreanu
Visual motion is an ethologically important stimulus throughout the animal kingdom. In primates, motion perception relies on specific higher-order cortical regions. Although mouse primary visual cortex (V1) and higher-order visual areas show direction-selective (DS) responses, their role in motion perception remains unknown. Here, we tested whether V1 is involved in motion perception in mice. We developed a head-fixed discrimination task in which mice must report their perceived direction of motion from random dot kinematograms (RDKs)...
May 12, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29779050/proprioceptive-loss-and-the-perception-control-and-learning-of-arm-movements-in-humans-evidence-from-sensory-neuronopathy
#20
R Chris Miall, Nick M Kitchen, Se-Ho Nam, Hannah Lefumat, Alix G Renault, Kristin Ørstavik, Jonathan D Cole, Fabrice R Sarlegna
It is uncertain how vision and proprioception contribute to adaptation of voluntary arm movements. In normal participants, adaptation to imposed forces is possible with or without vision, suggesting that proprioception is sufficient; in participants with proprioceptive loss (PL), adaptation is possible with visual feedback, suggesting that proprioception is unnecessary. In experiment 1 adaptation to, and retention of, perturbing forces were evaluated in three chronically deafferented participants. They made rapid reaching movements to move a cursor toward a visual target, and a planar robot arm applied orthogonal velocity-dependent forces...
May 19, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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