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ckd and eye diseases

Craig Balmforth, Job J M H van Bragt, Titia Ruijs, James R Cameron, Robert Kimmitt, Rebecca Moorhouse, Alicja Czopek, May Khei Hu, Peter J Gallacher, James W Dear, Shyamanga Borooah, Iain M MacIntyre, Tom M C Pearson, Laura Willox, Dinesh Talwar, Muriel Tafflet, Christophe Roubeix, Florian Sennlaub, Siddharthan Chandran, Baljean Dhillon, David J Webb, Neeraj Dhaun
BACKGROUND. Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and there is an established association between vasculopathy affecting the kidney and eye. Optical coherence tomography (OCT) is a novel, rapid method for high-definition imaging of the retina and choroid. Its use in patients at high cardiovascular disease risk remains unexplored. METHODS. We used the new SPECTRALIS OCT machine to examine retinal and retinal nerve fiber layer (RNFL) thickness, macular volume, and choroidal thickness in a prospective cross-sectional study in 150 subjects: 50 patients with hypertension (defined as a documented clinic BP greater than or equal to 140/90 mmHg (prior to starting any treatment) with no underlying cause identified); 50 with CKD (estimated glomerular filtration rate (eGFR) 8-125 ml/min/1...
December 8, 2016: JCI Insight
Makiko Katagiri, Jun Shoji, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
PURPOSE: We investigated the relationship between vitreous levels of soluble receptor for advanced glycation end products (sRAGE) and vascular endothelial growth factor (VEGF) and renal function, and correlations between vitreous sRAGE levels and proliferative diabetic retinopathy (PDR) activity. METHODS: We examined 33 eyes from 33 patients with diabetes mellitus who underwent a vitrectomy (eight patients in the non-PDR [NPDR] group and 25 in the PDR group). Serum creatinine levels and estimated glomerular filtration rate (eGFR) were measured and classified according to the chronic kidney disease (CKD)-staging method...
November 9, 2016: International Ophthalmology
Kevin Phan, Cheryl Au, Paul Mitchell, Gerald Liew, Adam J H Plant, Sarah B Wang, Joseph Chiha, Aravinda Thiagalingam, George Burlutsky, Bamini Gopinath
BACKGROUND: Prior studies have suggested the association between incidence of coronary artery disease (CAD) with chronic kidney disease (CKD) and poor glomerular filtration function. However to the best of our knowledge, few studies have specifically assessed this relationship based on the severity of CAD as quantified using Extent and Gensini scores. METHODS: Between June 2009 and January 2012, data were collected from 1,680 participants as part of the Australian Heart Eye Study (AHES) cohort...
August 2016: Journal of Thoracic Disease
Je-Wook Yu, Myung-Shik Lee
The NLRP3 inflammasome is assembled and activated in certain types of myeloid cells upon sensing microbe-derived toxins or host-derived danger signals. Activation of the NLRP3 inflammasome by endogenous ligands has been discovered in various disorders, including metabolic syndrome, type 2 diabetes, atherosclerosis, gout, reperfusion injury of the heart, neurodegeneration, such as Alzheimer's disease, chronic kidney diseases, and macular degeneration of the eyes. Despite the potential significance of the NLRP3 inflammasome in the pathogenesis of several diseases, details on the activation mechanism of the NLRP3 inflammasome by a variety of stimulators have yet to be reported...
November 2016: Archives of Pharmacal Research
Oussama N Boundaoui, Todd E Woodruff
PURPOSE: To report a case of presumed furosemide-associated bilateral angle-closure glaucoma. METHODS: Retrospective case report with spectral domain anterior segment optical coherence tomography imaging. RESULTS: A 21-year-old African American woman in her 17th week of pregnancy presented with acute angle-closure glaucoma in both eyes after being started on furosemide in her first trimester for fluid overload. Intraocular pressures were elevated in the low 40s mm Hg bilateral (OU) and anterior chambers were shallow with narrow grade 1 angles on gonioscopy (Schaffer classification)...
August 2016: Journal of Glaucoma
Timur Erk
Founded in 1985, the Turkish Kidney Foundation serves the society with 3 dialysis centers and a 113-bed general hospital. Interacting with public authorities and advocating end-stage renal disease (ESRD) patients' rights are essential services of this non-governmental organization (NGO). Over the last 30 years, keeping with the trend of chronic kidney disease (CKD) in the country, the foundation raised awareness in the population for this condition and prepared an activity road map by using statistical facts and data...
2016: Clinical Nephrology
Rohan Chawla, Koushik Tripathy, Sunil Chaudhary, Swati Phuljhele, Pradeep Venkatesh
PURPOSE: To describe a case of hypertension and retinitis pigmentosa presenting with a unilateral macular star. METHODS: Case report. RESULTS: A 17-year-old female with chronic kidney disease and hypertension presented with a mild blurring of vision in the left eye. There was a history of night blindness. Both eyes had optic disc pallor, arteriolar attenuation, and peripheral bony spicules suggestive of the triad of retinitis pigmentosa. Macular star was seen in the left eye alone...
April 29, 2016: Seminars in Ophthalmology
Chee Wai Wong, Ecosse L Lamoureux, Ching-Yu Cheng, Gemmy Chui Ming Cheung, E Shyong Tai, Tien Y Wong, Charumathi Sabanayagam
BACKGROUND: Chronic kidney disease (CKD) has been shown to be associated with diabetic retinopathy (DR) and age-related macular degeneration (AMD), leading causes of blindness in elderly adults in previous studies. However, the association of CKD with visual impairment (VI) is not clear. We aimed to examine the association of CKD with VI and other age-related ocular diseases in a population-based sample of Asian adults. METHODS: We analyzed data from 10,033 adults aged 40-80 years who participated in the Singapore Epidemiology of Eye Diseases (SEED, 2004-11) Study...
March 2016: EBioMedicine
Wei Yan Ng, Boon Wee Teo, E Shyong Tai, Sunil Sethi, Ecosse Lamoureux, Wong Tien Yin, Charumathi Sabanayagam
BACKGROUND: Serum cystatin C, a novel marker of renal function has been shown to be superior to serum creatinine in predicting renal function decline and adverse outcomes of chronic kidney disease (CKD). Our aim was to investigate the association between cystatin C and retinopathy in adults without diabetes. METHODS: We examined 1725 Indian adults, aged 40-80 years who participated in the Singapore Indian Eye Study (2007-2009) and were free of diabetes mellitus...
September 2016: European Journal of Preventive Cardiology
Shumin Bao, Wen Huang, Yuanbo Liang, Liping Jiang, Fenghua Wang, Yi Peng, Guangjuan Zhang, Ningli Wang
Few studies have examined the relationship between retinal microvascular abnormalities and chronic kidney disease (CKD). This study aims to examine the association between retinal vessel diameters and CKD in the rural China in order to provide the scientific basis for the early detection and diagnosis for CKD.Participants and data were extracted from the Handan Eye Study, a population-based cross-sectional study performed from 2006 to 2007. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were summarized by the average arteriolar and venular caliber of each eye...
December 2015: Medicine (Baltimore)
Yong Du, Christin Heidemann, Angelika Schaffrath Rosario, Amanda Buttery, Rebecca Paprott, Hannelore Neuhauser, Thea Riedel, Andrea Icks, Christa Scheidt-Nave
OBJECTIVES: To investigate changes in type 2 diabetes care indicators over time in Germany. METHODS: Adults aged 45-79 years with type 2 diabetes were identified from two national health examination surveys conducted in 1997-1999 (GNHIES98, n=333) and in 2008-2011 (DEGS1, n=526). We examined diabetes care indicators including treatment and preventive targets (glycemic control, blood pressure (BP), total cholesterol (TC), smoking, weight reduction, sports activity), self-management and care process measures (glucose self-monitoring, holding a diabetes passport, annual foot and eye examination; statin use), and the presence of diabetes-specific complications (diabetic nephropathy, retinopathy, neuropathy, diabetic foot, amputations) and comorbid cardiovascular disease (CVD) or chronic kidney disease (CKD)...
2015: BMJ Open Diabetes Research & Care
Chee Wai Wong, Boon Wee Teo, Ecosse Lamoureux, Mohammad Kamran Ikram, Jie Jin Wang, E Shyong Tai, Sunil Sethi, Tien Yin Wong, Charumathi Sabanayagam
PURPOSE: We examined the association of CKD defined by serum creatinine, serum cystatin C, and albuminuria with moderate diabetic retinopathy (DR). METHODS: We examined 1,119 Indian adults with diabetes, aged 40-80 years, who participated in the Singapore Indian Eye Study (2007-2009), a population-based cross-sectional study. The associations of CKD defined by each of the three markers alone and in combination with moderate DR were examined using logistic regression models adjusted for potential confounding factors including duration of diabetes, smoking, body mass index, systolic blood pressure, and HbA1c...
2015: Journal of Diabetes Research
Hélène François, Xavier Mariette
Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by lymphoplasmacytic infiltration of the exocrine (salivary and lachrymal) glands that results in sicca symptoms (dryness of the eyes and mouth). Systemic complications can occur in pSS, but renal involvement is rare, affecting <10% patients. The most frequent form of nephropathy in pSS is tubulointerstitial nephritis (TIN), in which infiltration of the kidney by plasma cells is a key feature and shows similarity to the lymphoplasmacytic infiltration of the salivary glands...
February 2016: Nature Reviews. Nephrology
Shinji Kitajima, Yasunori Iwata, Kengo Furuichi, Akihiro Sagara, Yasuyuki Shinozaki, Tadashi Toyama, Norihiko Sakai, Miho Shimizu, Takeshi Sakurai, Shuichi Kaneko, Takashi Wada
BACKGROUND: Various sleep abnormalities, such as delayed sleep onset, frequent awakening and daytime sleepiness, deteriorate the quality of life in patients with chronic kidney disease (CKD), including those on haemodialysis (HD). Although there are some candidate causative molecules in the central nervous system, the contribution of peripheral blood cells (PBCs) remains unclear. In this study, we performed polysomnographic analysis in CKD patients and used PBCs to examine the expression of genes related to sleep and wakefulness states...
April 2016: Clinical and Experimental Nephrology
Ming-Shian Tsai, Yu-Chiao Wang, Yin-Hsien Kao, Long-Bin Jeng, Chia-Hung Kao
The purpose of this study was to determine the risk of surgical mortality and morbidity in patients with diabetes mellitus (DM) undergoing a gastrectomy for gastric cancer (GC). Using the Taiwan National Health Insurance Research Database, we identified 6284 patients who underwent gastrectomy for GC from 1999 to 2010. In addition, we created a non-DM control cohort consisting of 6268 patients who received gastrectomy during the same period. Compared with the non-DM cohort, the DM cohort exhibited a higher prevalence of preoperative coexisting medical conditions, namely hypertension, hyperlipidemia, coronary artery disease, chronic kidney disease, chronic pulmonary disease, stroke, and cirrhosis...
September 2015: Medicine (Baltimore)
Amy McGowan, Giuliana Silvestri, Evelyn Moore, Vittorio Silvestri, Christopher C Patterson, Alexander P Maxwell, Gareth J McKay
BACKGROUND: Chronic kidney disease (CKD) and hypertension are global public health problems associated with considerable morbidity, premature mortality and attendant healthcare costs. Previous studies have highlighted that non-invasive examination of the retinal microcirculation can detect microvascular pathology that is associated with systemic disorders of the circulatory system such as hypertension. We examined the associations between retinal vessel caliber (RVC) and fractal dimension (DF), with both hypertension and CKD in elderly Irish nuns...
2015: PloS One
Asafa R Adedeji, John Tumbo, Indiran Govender
BACKGROUND: Clinical guidelines are systematically developed statements that assist practitioners and patients to make healthcare decisions for specific clinical circumstances. Non-adherence of doctors to guidelines is thought to contribute significantly to poor delivery of clinical care, resulting in poor clinical outcomes. AIM: To investigate adherence of doctors in rural district hospitals to clinical guidelines using the South African Hypertension Guideline 2006 as an example...
2015: African Journal of Primary Health Care & Family Medicine
Rosaria Lupica, Michele Buemi, Alfredo Campennì, Domenico Trimboli, Valeria Canale, Valeria Cernaro, Domenico Santoro
We report a case of a diabetic patient with progressive chronic kidney disease and unexplained hypercalcemia. This unusual presentation and the investigation of all possible causes led us to perform a renal biopsy. The systemic sarcoidosis diagnosis was confirmed by the presence of interstitial multiple granulomas composed of epithelioid and multinucleated giant cells delimited by a thin fibrous reaction, and by pulmonary computed tomography finding of numerous lumps with ground-glass appearance. Sarcoidosis most commonly involves lungs, lymph nodes, skin and eyes, whilst kidney is less frequently involved...
July 6, 2015: World Journal of Nephrology
Jeffrey H William, Aubrey L Gilbert, Sylvia E Rosas
Intraocular hypertension is common during hemodialysis. Dialysis disequilibrium syndrome and intraocular hypertension occur via similar pathophysiologic mechanisms. These mechanisms may contribute to the development of glaucoma and cataracts in a patient population already at high risk for ocular abnormalities, given the common risk factors for chronic kidney disease and impaired aqueous humor outflow. We describe a patient with complicated diabetes mellitus, end-stage renal disease, and recent cataract surgery who developed severe intraocular hypertension during hemodialysis...
November 2015: Clinical Nephrology
Haitham Ezzat, Amr Mohab
Sleep disorders are common among the patients undergoing dialysis in end stage renal disease (ESRD). Although variable, their prevalence has been reported to be higher when compared to the general population. The most frequently reported complaints are insomnia, restless leg syndrome (RLS), sleep-disordered breathing and excessive daytime sleepiness (EDS). The aim of this study was to assess the prevalence of sleep disorders in end stage renal disease patients on regular hemodialysis (group I with 30 patients) and CKD patients (group II with 30 patients) in comparison to 30 normal population (control group)...
July 2015: Renal Failure
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