keyword
https://read.qxmd.com/read/38188164/diagnostic-value-of-artificial-intelligence-based-on-computed-tomography-ct-density-in-benign-and-malignant-pulmonary-nodules-a-retrospective-investigation
#21
JOURNAL ARTICLE
Wei Fan, Huitong Liu, Yan Zhang, Xiaolong Chen, Minggang Huang, Bingqiang Xu
OBJECTIVE: To evaluate the diagnostic value of artificial intelligence (AI) in the detection and management of benign and malignant pulmonary nodules (PNs) using computed tomography (CT) density. METHODS: A retrospective analysis was conducted on the clinical data of 130 individuals diagnosed with PNs based on pathological confirmation. The utilization of AI and physicians has been employed in the diagnostic process of distinguishing benign and malignant PNs. The CT images depicting PNs were integrated into AI-based software...
2024: PeerJ
https://read.qxmd.com/read/38184141/liquid-biopsy-in-lung-cancer
#22
REVIEW
Lan Li, Haixia Jiang, Bingjie Zeng, Xianzhao Wang, Yunxia Bao, Changqiang Chen, Lifang Ma, Jin Yuan
Lung cancer is a highly prevalent malignancy worldwide and the primary cause of mortality. The absence of systematic and standardized diagnostic approaches for identifying potential pulmonary nodules, early-stage cancers, and indeterminate tumors has led clinicians to consider tissue biopsy and pathological sections as the preferred method for clinical diagnosis, often regarded as the gold standard. The conventional tissue biopsy is an invasive procedure that does not adequately capture the diverse characteristics and evolving nature of tumors...
January 4, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38116291/liquid-biopsy-in-non-small-cell-lung-cancer-a-meta-analysis-of-state-of-the-art-and-future-perspectives
#23
Sara Franzi, Gabriele Seresini, Paolo Borella, Paola Rafaniello Raviele, Gianluca Bonitta, Giorgio Alberto Croci, Claudia Bareggi, Davide Tosi, Mario Nosotti, Silvia Tabano
Introduction: To date, tissue biopsy represents the gold standard for characterizing non-small-cell lung cancer (NSCLC), however, the complex architecture of the disease has introduced the need for new investigative approaches, such as liquid biopsy. Indeed, DNA analyzed in liquid biopsy is much more representative of tumour heterogeneity. Materials and methods: We performed a meta-analysis of 17 selected papers, to attest to the diagnostic performance of liquid biopsy in identifying EGFR mutations in NSCLC...
2023: Frontiers in Genetics
https://read.qxmd.com/read/38114815/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-revolutionizing-the-landscape-of-lung-disease-diagnostics
#24
REVIEW
Shinichi Yamamoto, Masayuki Nakayama
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a revolutionary diagnostic tool for lung diseases, including lung cancer, sarcoidosis, and lymphoproliferative diseases. This minimally invasive procedure offers a superior diagnostic yield while ensuring maximum patient safety when compared to traditional invasive techniques such as mediastinoscopy and thoracoscopy. By enabling real-time imaging and sampling of mediastinal and hilar lymph nodes and masses directly from the bronchoscope, EBUS-TBNA has redefined the precision of diagnostic bronchoscopy...
December 19, 2023: Journal of Medical Ultrasonics
https://read.qxmd.com/read/38090555/unnecessary-orchiectomy-due-to-atypical-sarcoidosis-manifesting-as-a-unilateral-scrotal-mass-a-case-report-and-literature-review
#25
Valeria Skopelidou, Pavel Hurník, Vladimir Židlík, Lubomír Tulinský, Jiří Lenz, Tomáš Balner, Dušan Žiak, Patricie Delongová, Rudolf Karas, Miroslava Škripková, Matěj Jendřejek
Sarcoidosis is a disease characterised primarily by lung tissue involvement. Extrapulmonary involvement, particularly in the genitourinary tract, is extremely rare, particularly when it comes to primary disease detection in this location. The gold standard in establishing a definitive diagnosis of sarcoidosis is a combination of the clinical picture, the results of imaging methods, and histopathological examination from the biopsy taken (thus ruling out other causes of granulomatous inflammation). However, it is common for the biopsy to be infeasible or for the patient to refuse such an examination, resulting in the neglect of this critical verification...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38086393/tidal-volume-expandability-and-ventilatory-efficiency-as-predictors-of-mortality-in-taiwanese-male-patients-with-chronic-obstructive-pulmonary-disease-a-10-year-follow-up-study-is-v%C3%AC-o-2peak-or-fev-1-the-gold-standard
#26
JOURNAL ARTICLE
Ming-Lung Chuang, Yu-Hsun Wang
Despite our knowledge of the risk factors for mortality associated with chronic obstructive pulmonary disease (COPD), the mortality rate for this condition continues to increase. This study aimed to investigate the predictive power of physiological variables on all-cause mortality in COPD patients compared to peak oxygen uptake (<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mover><mml:mi>V</mml:mi><mml:mo>˙</mml:mo></mml:mover></mml:mrow></mml:math>O2peak ) and forced expired volume in one second (FEV1 )...
2023: Chronic Respiratory Disease
https://read.qxmd.com/read/38083482/automatic-lung-cancer-subtypes-classification-on-ct-images-with-self-generated-multi-modality-hybrid-features
#27
JOURNAL ARTICLE
Gege Ma, Yuan Jin, Jianhu Pan, Shaoting Zhang, Dimitris N Metaxas, Wentao Zhu
Lung cancer is a malignant tumor with rapid progression and high fatality rate. According to histological morphology and cell behaviours of cancerous tissues, lung cancer can be classified into a variety of subtypes. Since different cancer subtype corresponds to distinct therapies, the early and accurate diagnosis is critical for following treatments and prognostic managements. In clinical practice, the pathological examination is regarded as the gold standard for cancer subtypes diagnosis, while the disadvantage of invasiveness limits its extensive use, leading the non-invasive and fast-imaging computed tomography (CT) test a more commonly used modality in early cancer diagnosis...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38082917/global-and-regional-lung-function-assessment-using-portable-electrical-impedance-tomography-eit-system-clinical-study
#28
JOURNAL ARTICLE
Fedi Zouari, Pak To Cheung, Adrien Touboul, Wang C Kwok, Venice Sin, Eddie C Wong, Iris Y Zhou, Terence C C Tam, Russell W Chan
Recent development of affordable, portable and self-administrable electrical impedance tomography (EIT) system demonstrated the feasibility of using standalone EIT and subject's anthropometrics to predict the gold standard spirometry indicators for lung-function assessment. Compared to spirometry, the system showed the advantage of providing spatial mapping of the spirometry indicators. Nevertheless, the previous study was limited to healthy subjects. Here, we recruited (N=88): 47 lung disease patients and 41 healthy controls to perform simultaneous EIT and spirometry measurements to validate the capabilities of the system...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38069222/opaganib-abc294640-induces-immunogenic-tumor-cell-death-and-enhances-checkpoint-antibody-therapy
#29
JOURNAL ARTICLE
Lynn W Maines, Staci N Keller, Charles D Smith
Antibody-based cancer drugs that target the checkpoint proteins CTLA-4, PD-1 and PD-L1 provide marked improvement in some patients with deadly diseases such as lung cancer and melanoma. However, most patients are either unresponsive or relapse following an initial response, underscoring the need for further improvement in immunotherapy. Certain drugs induce immunogenic cell death (ICD) in tumor cells in which the dying cells promote immunologic responses in the host that may enhance the in vivo activity of checkpoint antibodies...
November 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38067372/sarcopenia-and-mediastinal-adipose-tissue-as-a-prognostic-marker-for-short-and-long-term-outcomes-after-primary-surgical-treatment-for-lung-cancer
#30
JOURNAL ARTICLE
Florian Ponholzer, Georg Groemer, Caecilia Ng, Herbert Maier, Paolo Lucciarini, Florian Kocher, Dietmar Öfner, Eva Gassner, Stefan Schneeberger, Florian Augustin
Surgical resection remains the gold standard of treatment for early-stage lung cancer. Several risk models exist to predict postoperative morbidity and mortality. Psoas muscle sarcopenia has already successfully been used for morbidity prediction in lung transplantation and is not yet included in the available risk scores for pulmonary resections. We hypothesized that the skeletal muscle index and mediastinal adipose tissue might also have an impact on postoperative outcomes after primary surgery for primary lung cancer...
November 30, 2023: Cancers
https://read.qxmd.com/read/38061504/the-effect-of-deep-learning-based-lesion-segmentation-on-failure-load-calculations-of-metastatic-femurs-using-finite-element-analysis
#31
JOURNAL ARTICLE
Ali Ataei, Florieke Eggermont, Nico Verdonschot, Nikolas Lessmann, Esther Tanck
Bone ranks as the third most frequent tissue affected by cancer metastases, following the lung and liver. Bone metastases are often painful and may result in pathological fracture, which is a major cause of morbidity and mortality in cancer patients. To quantify fracture risk, finite element (FE) analysis has shown to be a promising tool, but metastatic lesions are typically not specifically segmented and therefore their mechanical properties may not be represented adequately. Deep learning methods potentially provide the opportunity to automatically segment these lesions and change the mechanical properties more adequately...
December 5, 2023: Bone
https://read.qxmd.com/read/38060569/the-association-between-cardiopulmonary-exercise-testing-and-postoperative-outcomes-in-patients-with-lung-cancer-undergoing-lung-resection-surgery-a-systematic-review-and-meta-analysis
#32
JOURNAL ARTICLE
Nabeela Arbee-Kalidas, Hlamatsi Jacob Moutlana, Yoshan Moodley, Moses Mogakolodi Kebalepile, Palesa Motshabi Chakane
BACKGROUND: Exercise capacity should be determined in all patients undergoing lung resection for lung cancer surgery and cardiopulmonary exercise testing (CPET) remains the gold standard. The purpose of this study was to investigate associations between preoperative CPET and postoperative outcomes in patients undergoing lung resection surgery for lung cancer through a review of the existing literature. METHODS: A search was conducted on PubMed, Scopus, Cochrane Library and CINAHL from inception until December 2022...
2023: PloS One
https://read.qxmd.com/read/38058061/different-endotracheal-intubations-for-non-small-cell-lung-cancer-surgery-a-retrospective-case-matched-study-on-postoperative-complications-and-quality-of-life
#33
JOURNAL ARTICLE
Mengzhe Zhang, Zengtuan Xiao, Chen Chen, Guiyue Wang, Xiaofei Wang, Yunqi Jia, Yiqing Yin, Zhenfa Zhang
BACKGROUND: Lung isolation and separation is still controversial in thoracic surgery. Preferences of the surgeon can drive the decision to use single- vs. double-lumen endotracheal intubation. We aimed to compare complications and quality of life (QOL) after radical lung cancer resection with a single-lumen tube (ST) and a double-lumen tube (DT) for patients with non-small cell lung cancer (NSCLC). METHODS: A total of 309 patients who underwent radical lung cancer resection with video-assisted thoracoscopy-lobectomy were subsequently included in the study...
December 2023: Discovery Medicine
https://read.qxmd.com/read/38056849/-perioperative-management-of-deep-vein-thrombosis-and-treatment-of-pulmonary-embolism
#34
JOURNAL ARTICLE
Yasushi Shintani
Preoperative evaluation of deep vein thrombosis( DVT), which is a known risk factor for the development of pulmonary embolism( PE), is important prior to performing thoracic surgery. The incidence of DVT after thoracic surgery is estimated to be 4% and the incidence of PE 0.6%. Lung cancer may be responsible for the highest incidence of thrombotic events associated with cancer. Longer operative time, intraoperative bleeding, extended surgical injury, pneumonectomy, and incomplete resection are all correlated to higher chance of acute PE after thoracic surgery...
September 2023: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38045245/navigational-bronchoscopy-versus-computed-tomography-guided-transthoracic-needle-biopsy-for-the-diagnosis-of-indeterminate-lung-nodules-protocol-and-rationale-for-the-veritas-multicenter-randomized-trial
#35
Robert J Lentz, Katherine Frederick-Dyer, Virginia B Planz, Tatsuki Koyama, Matthew C Aboudara, Briana Swanner, Lance Roller, See-Wei Low, Cristina Salmon, Sameer K Avasarala, Todd C Hoopman, Momen M Wahidi, Kamran Mahmood, George Z Cheng, James M Katsis, Jonathan S Kurman, Pierre-François D'Haese, Joyce Johnson, Eric L Grogan, Charla Walston, Lonny Yarmus, Gerard A Silvestri, Otis B Rickman, Najib M Rahman, Fabien Maldonado
BACKGROUND: Lung nodule incidence is increasing. Many nodules require biopsy to discriminate between benign and malignant etiologies. The gold-standard for minimally invasive biopsy, computed tomography-guided transthoracic needle biopsy (CT-TTNB), has never been directly compared to navigational bronchoscopy, a modality which has recently seen rapid technological innovation and is associated with improving diagnostic yield and lower complication rate. Current estimates of the diagnostic utility of both modalities are based largely on non-comparative data with significant risk for selection, referral, and publication biases...
November 23, 2023: medRxiv
https://read.qxmd.com/read/38003273/circulating-tumour-cells-detection-and-application-in-advanced-non-small-cell-lung-cancer
#36
REVIEW
Kalliopi Andrikou, Tania Rossi, Alberto Verlicchi, Ilaria Priano, Paola Cravero, Marco Angelo Burgio, Lucio Crinò, Sara Bandini, Paola Ulivi, Angelo Delmonte
Non-small cell lung cancer (NSCLC) is one of the deadliest diseases worldwide. Tissue biopsy is the current gold standard for the diagnosis and molecular profiling of NSCLC. However, this approach presents some limitations due to inadequate tissue sampling, and intra- and intertumour heterogenicity. Liquid biopsy is a noninvasive method to determine cancer-related biomarkers in peripheral blood, and can be repeated at multiple timepoints. One of the most studied approaches to liquid biopsies is represented by circulating tumour cells (CTCs)...
November 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37996118/staging-by-thoracoscopy-in-potentially-radically-treatable-lung-cancer-associated-with-minimal-pleural-effusion-stratify-protocol-of-a-prospective-multicentre-observational-study
#37
JOURNAL ARTICLE
Jenny Ferguson, Selina Tsim, Caroline Kelly, Laura Alexander, Shumaila Shad, Mark Neilly, Matthew Tate, Baryab Zahra, Merna Saleh, Gordon Cowell, Elspeth Banks, Seamus Grundy, John Corcoran, Nicola Downer, Andrew Stanton, Matthew Evison, Najib M Rahman, Nick Maskell, Kevin G Blyth
INTRODUCTION: Recurrence rate following radical therapy for lung cancer remains high, potentially reflecting occult metastatic disease, and better staging tools are required. Minimal pleural effusion (mini-PE) is associated with particularly high recurrence risk and is defined as an ipsilateral pleural collection (<1/3 hemithorax on chest radiograph), which is either too small to safely aspirate fluid for cytology using a needle, or from which fluid cytology is negative. Thoracoscopy (local anaesthetic thoracoscopy (LAT) or video-assisted thoracoscopic surgery (VATS)) is the gold-standard diagnostic test for pleural malignancy in patients with larger symptomatic effusions...
November 23, 2023: BMJ Open Respiratory Research
https://read.qxmd.com/read/37981101/preoperative-mediastinal-staging-in-early-stage-lung-cancer-targeted-nodal-sampling-is-not-inferior-to-systematic-nodal-sampling
#38
JOURNAL ARTICLE
Kerrie A Sullivan, Forough Farrokhyar, Yogita S Patel, Moishe Liberman, Simon R Turner, Anne V Gonzalez, Rahul Nayak, Kazuhiro Yasufuku, Waël C Hanna
OBJECTIVE: To determine whether targeted sampling (TS), which omits biopsy of triple- normal lymph nodes (LNs) on positron emission tomography, computed tomography, and endobronchial ultrasound (EBUS), is noninferior to systematic sampling (SS) of mediastinal LNs during EBUS for staging of patients with early-stage non-small cell lung cancer (NSCLC). METHODS: Patients who are clinical nodal (cN)0-N1 with suspected NSCLC eligible for EBUS based on positron emission tomography/computed tomography were enrolled in this prospective, multicenter trial...
November 21, 2023: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37980239/long-term-survival-analysis-of-pleural-mesothelioma-patients-undergoing-surgery-brief-report-from-a-tertiary-referral-centre
#39
JOURNAL ARTICLE
Riccardo Orlandi, Giovanni Leuzzi, Luigi Rolli, Michele Ferrari, Alessia Stanzi, Camilla Valsecchi, Ugo Pastorino
OBJECTIVES: to date, no consensus has been reached on the surgical gold-standard in pleural mesothelioma (PM). We retrospectively reviewed our experience as a tertiary referral centre, to compare short- and long-term survival of PM patients undergoing different types of surgery. METHODS: in retrospective, observational, single-centre study, we analysed all the patients histologically diagnosed with PM undergoing surgical procedures with palliative or curative intent at IRCCS Istituto Nazionale dei Tumori of Milan, Italy, from January 2003 to December 2020...
October 24, 2023: Clinical Lung Cancer
https://read.qxmd.com/read/37970683/completely-portal-robotic-pancoast-tumour-resection-with-en-bloc-resection-of-the-left-upper-lobe-and-chest-wall
#40
Gregor Kocher, Sarah Deckarm, Dominik Flury
The current gold standard for the treatment of Pancoast tumours is considered to be neoadjuvant chemoradiation followed by radical resection of the affected upper lobe en bloc with resection of the chest wall. Shaw and Paulson first described the most commonly used approach in 1961 via an extended posterolateral thoracotomy. However, because this approach comes with significant soft tissue damage and occasionally provides only suboptimal exposure, especially for anterior superior sulcus tumours, other approaches have been published in recent years, including open anterior approaches (Dartevelle and Gruenenwald) in addition to rare case reports of minimally invasive assisted hybrid procedures...
November 15, 2023: Multimedia Manual of Cardiothoracic Surgery: MMCTS
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