keyword
https://read.qxmd.com/read/38496695/fibre-based-fluorescence-lifetime-imaging-microscopy-a-real-time-biopsy-guidance-tool-for-suspected-lung-cancer
#1
JOURNAL ARTICLE
Susan Fernandes, Elvira Williams, Neil Finlayson, Hazel Stewart, Catharine Dhaliwal, David A Dorward, William A Wallace, Ahsan R Akram, James Stone, Kevin Dhaliwal, Gareth O S Williams
Lung cancer is the most common cause of cancer-related deaths worldwide. Early detection improves outcomes, however, existing sampling techniques are associated with suboptimal diagnostic yield and procedure-related complications. Autofluorescence-based fluorescence-lifetime imaging microscopy (FLIM), a technique which measures endogenous fluorophore decay rates, may aid identification of optimal biopsy sites in suspected lung cancer. Our fibre-based fluorescence-lifetime imaging system, utilising 488 nm excitation, which is deliverable via existing diagnostic platforms, enables real-time visualisation and lifetime analysis of distal alveolar lung structure...
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38494909/impact-of-indocyanine-green-on-prolonged-air-leak-in-minimally-invasive-segmentectomy
#2
JOURNAL ARTICLE
Quentin Rudondy, Sebastien Frey, Imad Bentellis, Tayeb Benkirane, Charlotte Cohen, Jonathan Benzaquen, Marius Ilie, Abel Gomez-Caro, Jean-Phillippe Berthet
BACKGROUND: Video-assisted thoracoscopic segmentectomies have become the gold standard for the treatment of early-stage non-small cell lung cancer less than two centimeters. The main difficulty is the identification of intersegmental boundary lines which dictate postoperative morbidities. METHODS: We conducted a retrospective study to compare the perioperative outcomes of patients who underwent minimally invasive segmentectomy using the traditional deflation-inflation method or the novel indocyanine green (ICG) technique...
March 18, 2024: Thoracic Cancer
https://read.qxmd.com/read/38494270/phytocompounds-based-therapeutic-approach-investigating-curcumin-and-green-tea-extracts-on-mcf-7-breast-cancer-cell-line
#3
JOURNAL ARTICLE
Radwa M Fawzy, Amal A Abdel-Aziz, Khalid Bassiouny, Aysam M Fayed
BACKGROUND: Breast cancer (BC) has transcended lung cancer as the most common cancer in the world. Due to the disease's aggressiveness, rapid growth, and heterogeneity, it is crucial to investigate different therapeutic approaches for treatment. According to the World Health Organization (WHO), Plant-based therapeutics continue to be utilized as safe/non-toxic complementary or alternative treatments for cancer, even in developed countries, regardless of how cutting-edge conventional therapies are...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38476352/stereotactic-body-radiotherapy-in-lung-cancer-a-contemporary-review
#4
REVIEW
Emese Csiki, Mihály Simon, Judit Papp, Márton Barabás, Johanna Mikáczó, Kristóf Gál, David Sipos, Árpád Kovács
The treatment of early stage non-small cell lung cancer (NSCLC) has improved enormously in the last two decades. Although surgery is not the only choice, lobectomy is still the gold standard treatment type for operable patients. For inoperable patients stereotactic body radiotherapy (SBRT) should be offered, reaching very high local control and overall survival rates. With SBRT we can precisely irradiate small, well-defined lesions with high doses. To select the appropriate fractionation schedule it is important to determine the size, localization and extent of the lung tumor...
2024: Pathology Oncology Research: POR
https://read.qxmd.com/read/38457174/advances-in-lung-cancer-surgery-the-role-of-segmentectomy-in-early-stage-management
#5
REVIEW
Luca Bertolaccini, Monica Casiraghi, Clarissa Uslenghi, Cristina Diotti, Antonio Mazzella, Giovanni Caffarena, Lorenzo Spaggiari
INTRODUCTION: The evolving landscape of surgical interventions for early-stage non-small cell lung cancer (NSCLC) necessitates a reassessment of the traditional gold standard of lobectomy versus emerging sublobar resections, prompting this critical narrative review. AREAS COVERED: This review encompasses recent randomized controlled trials, notably JCOG0802/WJOG4607L and CALGB140503, comparing lobectomy and sublobar resections for early-stage NSCLC, focusing on tumor size and recurrence rates...
March 8, 2024: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38448801/bone-mineral-density-in-lower-thoracic-vertebra-for-osteoporosis-diagnosis-in-older-adults-during-ct-lung-cancer-screening
#6
JOURNAL ARTICLE
Nandong Hu, Miaomiao Wang, Meng Yang, Xin Chen, Jiangchuan Wang, Chao Xie, Bin Zhang, Zhongqiu Wang, Xiao Chen
BACKGROUND: Quantitative computed tomography (QCT)-based lumbar bone mineral density (LBMD) has been used to diagnose osteoporosis. This study explored the value of lower thoracic BMD (TBMD) in diagnosing osteoporosis in older adults during CT lung cancer screening. METHODS: This study included 751 subjects who underwent QCT scans with both LBMD and TBMD. 141 of them was selected for a validation. Osteoporosis was diagnosed based on LBMD using the ACR criteria (gold standard)...
March 6, 2024: BMC Geriatrics
https://read.qxmd.com/read/38432026/the-danish-lung-cancer-registry-a-nationwide-validation-study
#7
JOURNAL ARTICLE
Anja Gouliaev, Fatima Ali, Erik Jakobsen, Susanne O Dalton, Ole Hilberg, Torben R Rasmussen, Niels L Christensen
BACKGROUND: This study evaluates the validity of the information in the Danish Lung Cancer Registry (DLCR). Since 2000, the DLCR has been a tool for monitoring interventions and outcome of all Danish lung cancer patients with the intent to streamline and improve treatment and survival. The DLCR receives information from the Danish Patient Registries in addition to clinical information from the treating physicians. In the year 2022, more than 50 papers have been published using DLCR as a data source...
February 29, 2024: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/38420812/tumor-educated-platelet-rna-and-circulating-free-rna-emerging-liquid-biopsy-markers-for-different-tumor-types
#8
REVIEW
Haiyang Hu, Huangqin Song, Bin Han, Haoliang Zhao, Jiefeng He
The incidence and mortality from malignant tumors continue to rise each year. Consequently, early diagnosis and intervention are vital for improving patient' prognosis and survival. The traditional pathological tissue biopsy is currently considered the gold standard for cancer diagnosis. However, it suffers from several limitations including invasiveness, sometimes not repeatable or unsuitable, and the inability to capture the dynamic nature of tumors in terms of space and time. Consequently, these limit the application of tissue biopsies for the diagnosis of early-stage tumors and have redirected the research focus towards liquid biopsies...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38411206/lobar-or-sublobar-resection-of-peripheral-stage-i-non-small-cell-lung-cancer
#9
JOURNAL ARTICLE
Pedro Guimarães Rocha Lima, Matthieu Glorion, Moishe Liberman
PURPOSE OF REVIEW: We aim to highlight two recent clinical trials that have altered the approach of the management of stage I nonsmall cell lung cancer. RECENT FINDINGS: The JCOG 0802 and CALGB 140503 trials demonstrated that sublobar resection is noninferior to lobectomy for overall and disease-free survival in patients with stage I nonsmall cell lung cancer. SUMMARY: Since 1962, lobectomy has been deemed the gold standard treatment for operable lung cancer...
February 27, 2024: Current Opinion in Pulmonary Medicine
https://read.qxmd.com/read/38372784/tep-rna-a-new-frontier-for-early-diagnosis-of-nsclc
#10
REVIEW
Yuan Wang, Aiping Dong, Minhan Jin, Shirong Li, Yang Duan
BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer (LC), which is the leading cause of tumor mortality. In recent years, compared with tissue biopsy, which is the diagnostic gold standard for tumor diagnosis, Liquid biopsy (LB) is considered to be a more minimally invasive, sensitive, and safer alternative or auxiliary diagnostic method. However, the current value of LB in early diagnosis of LC is not ideal, so it is particularly important to study the changes in blood composition during the process of tumorigenesis and find more sensitive biomarkers...
February 19, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38372537/the-use-of-biomarkers-in-the-diagnosis-of-lung-cancer
#11
JOURNAL ARTICLE
Mona Mlika, Faouzi Mezni
Using a simple 10 to 20 milliliters of blood sample in order to make the diagnosis of lung cancer is the dream of every patient and practitioner. In fact, even if tissue samples or bronchial liquid represent the gold standard for microscopic diagnosis, using less invasive procedures represented the aim of many researches published in the literature. The utility of biomarkers has been widely reported in screening context, mainly in association to low dose CT-scan, or in therapeutic context in order to highlight therapeutic targets or to change treatment in a context of resistance to target therapies...
April 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38352000/endobronchial-ultrasound-a-novel-screening-test-for-pulmonary-hypertension-prior-to-major-pulmonary-surgery
#12
JOURNAL ARTICLE
Nathaniel Deboever, George A Eapen, Roberto F Casal, Jean-Bernard Durand, Michael A Eisenberg, Hope Feldman, Celestino May, Zohra Ali, David C Rice, Reza J Mehran
OBJECTIVES: Pulmonary hypertension (PH) is an important physiologic variable in the assessment of patients undergoing major thoracic operations but all too often neglected because of the need for right heart catheterization (RHC) due to the inaccuracy of transthoracic echocardiography. Patients with lung cancer often require endobronchial ultrasound (EBUS) as part of the staging of the cancer. We sought to investigate whether EBUS can be used to screen these patients for PH. METHODS: Patients undergoing a major thoracic operation requiring EBUS for staging were included prospectively in the study...
February 2024: JTCVS techniques
https://read.qxmd.com/read/38333112/plasma-ddpcr-for-the-detection-of-met-amplification-in-advanced-nsclc-patients-a-comparative-real-world-study
#13
JOURNAL ARTICLE
Jun-Wei Su, Cheng-Di Weng, Xiao-Cheng Lin, Mei-Mei Fang, Xiao Xiao, Yi-Chen Zhang, Xu-Chao Zhang, Jian Su, Chong-Rui Xu, Hong-Hong Yan, Hua-Jun Chen, Yi-Long Wu, Jin-Ji Yang
BACKGROUND: Mesenchymal-epithelial transition ( MET ) amplification is a crucial oncogenic driver and a resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) of non-small-cell lung cancer (NSCLC). Fluorescence in situ hybridization (FISH) is the gold standard for MET amplification detection. However, it is inapplicable when tissue samples are unavailable. OBJECTIVE: This study assessed the performance of plasma droplet digital polymerase chain reaction (ddPCR) in MET amplification detection in NSCLC patients...
2024: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/38311066/video-assisted-mediastinoscopic-lymphadenectomy-vamla-mature-results-for-staging-non-small-cell-lung-cancer-with-normal-mediastinum
#14
JOURNAL ARTICLE
Sergi Call, Nina Reig-Oussedik, Carme Obiols, José Sanz-Santos, Juan Manuel Ochoa-Alba, Lucía Reyes Cabanillas, Mireia Serra-Mitjans, Ramón Rami-Porta
OBJECTIVES: The aim of this study is to analyze the accuracy of video-assisted mediastinoscopic lymphadenectomy (VAMLA) and the unsuspected (u) N2-3 rates in patients with non-small cell lung cancer (NSCLC) and normal mediastinum by integrated positron emission tomography (PET) - computed tomography (CT). METHODS: Prospective observational single-center study of 603 consecutive VAMLAs from 2010 to 2022. EXCLUSION CRITERIA: other indications (n=32); tumors different from NSCLC (n=91); cN2-3 tumors by PET-CT (n=46)...
February 2, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38290794/a-successful-shift-from-thoracotomy-to-video-assisted-thoracoscopic-lobectomy-for-non-small-cell-lung-cancer-in-a-low-volume-center
#15
JOURNAL ARTICLE
Viktor Asbjornsson, Gyda Johannsdottir, Daniel Myer, Thorri Geir Runarsson, Leon Arnar Heitmann, Gudrun N Oskarsdottir, Per Martin Silverborn, Henrik Jessen Hansen, Tomas Gudbjartsson
OBJECTIVES: Although video-assisted thoracoscopic (VATS)-lobectomy has become the gold standard for pulmonary resections of NSCLC, lobectomy is still performed via thoracotomy in many European and North American centers. VATS-lobectomy was implemented overnight from thoracotomy in our low-volume center in early 2019, after one senior surgeon undertook observership VATS-training overseas, and immediately became the mainstay of surgical treatment for non-small cell lung cancer (NSCLC) in Iceland...
January 30, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38246326/a-multicenter-retrospective-case-control-study-on-simple-versus-extended-sleeve-lobectomies
#16
JOURNAL ARTICLE
Alessio Campisi, Andrea Dell'Amore, Eleonora Faccioli, Wentao Fang, Tangbin Chen, Chunyu Ji, Piotr Gabryel, Magdalena Sielewicz, Cezary Piwkowski, Samina Park, Young Tae Kim, Stefano Bongiolatti, Giovanni Mugnaini, Luca Voltolini, Chiara Catelli, Riccardo Giovannetti, Maurizio Infante, Luca Bertolaccini, Lorenzo Spaggiari, Jonas Ehrsam, Othmar Schöb, Ilhan Inci, Federico Rea
BACKGROUND: Sleeve resection is currently the gold standard procedure for centrally located non-small cell lung cancer (NSCLC). Extended sleeve lobectomies(ESL) consist in an atypical bronchoplasty with resection of more than one lobe, and carry several technical difficulties compared to simple sleeve lobectomy(SSL). Our study aimed to compare the outcomes of ESL and SSL for NSCLC. METHODS: This multicenter, retrospective, cohort study included 1314 patients who underwent ESL (155 patients) or SSL (1159 patients) between 2000 and 2018...
January 19, 2024: Annals of Thoracic Surgery
https://read.qxmd.com/read/38225616/advancing-accuracy-in-breath-testing-for-lung-cancer-strategies-for-improving-diagnostic-precision-in-imbalanced-data
#17
JOURNAL ARTICLE
Ke-Cheng Chen, Shuenn-Wen Kuo, Ruei-Hao Shie, Hsiao-Yu Yang
BACKGROUND: Breath testing using an electronic nose has been recognized as a promising new technique for the early detection of lung cancer. Imbalanced data are commonly observed in electronic nose studies, but methods to address them are rarely reported. OBJECTIVE: The objectives of this study were to assess the accuracy of electronic nose screening for lung cancer with imbalanced learning and to select the best mechanical learning algorithm. METHODS: We conducted a case‒control study that included patients with lung cancer and healthy controls and analyzed metabolites in exhaled breath using a carbon nanotube sensor array...
January 16, 2024: Respiratory Research
https://read.qxmd.com/read/38224684/pituitary-metastasis-arising-from-hepatocellular-carcinoma-a-case-report-and-update-of-the-literature
#18
JOURNAL ARTICLE
Isaac Rodriguez, Lena Vogel, Constantin Dreher, Asan Cherkezov, Frank Giordano, Matthias Frölich, Matthias Philip Ebert, Andreas Teufel, Judit Boda-Heggemann
Hepatocellular carcinoma (HCC) is the sixth most common neoplasia and the third leading cause of cancer-associated deaths worldwide. Most cases arise in patients with cirrhosis, and early detection through periodic screening can make it potentially curable. The presence of extrahepatic metastases (EHM) affects treatment decisions and curability. The lungs are the most common site for EHM, followed by lymph nodes, bones, and the adrenal glands. Interestingly, approximately only 15 cases of HCC metastasizing to the pituitary gland have been reported so far...
January 15, 2024: Zeitschrift Für Gastroenterologie
https://read.qxmd.com/read/38219419/mesbc-a-novel-mutually-exclusive-spectral-biclustering-method-for-cancer-subtyping
#19
JOURNAL ARTICLE
Fengrong Liu, Yaning Yang, Xu Steven Xu, Min Yuan
Many soft biclustering algorithms have been developed and applied to various biological and biomedical data analyses. However, few mutually exclusive (hard) biclustering algorithms have been proposed, which could better identify disease or molecular subtypes with survival significance based on genomic or transcriptomic data. In this study, we developed a novel mutually exclusive spectral biclustering (MESBC) algorithm based on spectral method to detect mutually exclusive biclusters. MESBC simultaneously detects relevant features (genes) and corresponding conditions (patients) subgroups and, therefore, automatically uses the signature features for each subtype to perform the clustering...
December 28, 2023: Computational Biology and Chemistry
https://read.qxmd.com/read/38212892/n-cadherin-a-diagnostic-marker-to-help-discriminate-primary-liver-carcinomas-from-extrahepatic-carcinomas
#20
JOURNAL ARTICLE
Tiemo S Gerber, Dirk A Ridder, Benjamin Goeppert, Alexander Brobeil, Philipp Stenzel, Stefanie Zimmer, Jörg Jäkel, Marie Oliver Metzig, Roxana Schwab, Steve Z Martin, András Kiss, Frank Bergmann, Peter Schirmacher, Peter R Galle, Hauke Lang, Wilfried Roth, Beate K Straub
Distinguishing primary liver cancer (PLC), namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), from liver metastases is of crucial clinical importance. Histopathology remains the gold standard, but differential diagnosis may be challenging. While absent in most epithelial, the expression of the adherens junction glycoprotein N-cadherin is commonly restricted to neural and mesenchymal cells, or carcinoma cells that undergo the phenomenon of epithelial-to-mesenchymal transition (EMT)...
January 11, 2024: International Journal of Cancer. Journal International du Cancer
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