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AMPK AND Sirt1

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https://www.readbyqxmd.com/read/29150224/reduced-gene-expression-of-sirtuins-and-active-ampk-levels-in-children-and-adolescents-with-obesity-and-insulin-resistance
#1
Zahra Arab Sadeghabadi, Mitra Nourbakhsh, Parvin Pasalar, Solaleh Emamgholipour, Abolfazl Golestani, Bagher Larijani, Maryam Razzaghy-Azar
BACKGROUND: Sirtuins, including SIRT1 and SIRT2, are longevity-associated deacetylase enzymes that modulate metabolic homeostasis in response to the cellular energy state. Adenosine monophosphate activated protein kinase (AMPK) and SIRT1 are interrelated and share several common target pathways. This study aimed to evaluate the SIRT1 and SIRT2 gene expression in peripheral blood mononuclear cells (PBMCs) as well as plasma levels of AMPK, in obese children and adolescents. MATERIALS AND METHODS: Participants included 60 children and adolescents (30 obese and 30 age- and gender-matched control subjects)...
November 14, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29130531/acute-hypoxic-preconditioning-prevents-palmitic-acid-induced-cardiomyocyte-apoptosis-via-switching-metabolic-glut4-glucose-pathway-back-to-cd36-fatty-acid-dependent
#2
Yeh-Peng Chen, Wei-Wen Kuo, Rathinasamy Baskaran, Cecilia-Hsuan Day, Ray-Jade Chen, Su-Ying Wen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Chia-Hua Kuo, Chih-Yang Huang
Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myocardial cell damage leads to an imbalance of energy metabolism, and many studies have indicated that short-term hypoxia during myocardial cell injury has a protective effect. In our previous animal studies, we found that short-term hypoxia in the heart has a protective effect, but long-term hypoxia increases myocardial cell injury. Palmitic acid (PA)-treated H9c2 cardiomyoblasts and neonatal rat ventricle cardiomyocytes were used to simulate hyperlipidemia model, which suppress cluster of differentiation 36 (CD36) and activate glucose transporter type 4 (GLUT4)...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29125913/standardized-kaempferia-parviflora-extract-enhances-exercise-performance-through-activation-of-mitochondrial-biogenesis
#3
Mi-Bo Kim, Taeyoon Kim, Changhee Kim, Jae-Kwan Hwang
Exercise enhances mitochondrial biogenesis in skeletal muscle. Increased mitochondrial function and content can contribute to the improvement in skeletal muscle function and the benefits of exercise by increasing the response to energy demands. The effect of standardized Kaempferia parviflora extract (KPE) on exercise performance was accessed in L6 myotubes and C57BL/6J mice. KPE significantly activated peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and increased mitochondrial density in L6 myotubes...
November 10, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29113798/fucoxanthin-attenuates-fatty-acid-induced-lipid-accumulation-in-fl83b-hepatocytes-through-regulated-sirt1-ampk-signaling-pathway
#4
Yi-Hsien Chang, Ya-Ling Chen, Wen-Chung Huang, Chian-Jiun Liou
The fucoxanthin, isolated from brown algae, was reported to have multiple biological functions to anti-inflammation, anti-tumor, and ameliorated obesity in mice. In this study we investigated whether fucoxanthin could inhibit lipids accumulation in FL83B hepatocytes. FL83B cells were induced as fatty liver cell model by 0.5 mM oleic acid for 48 h, and treated with various concentration of fucoxanthin for 24 h. The results demonstrated that fucoxanthin significantly suppressed lipid accumulation and decreased lipid peroxidation in hepatocytes...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29097705/metoprolol-prevents-chronic-obstructive-sleep-apnea-induced-atrial-fibrillation-by-inhibiting-structural-sympathetic-nervous-and-metabolic-remodeling-of-the-atria
#5
Li Sun, Sen Yan, Xiaoyu Wang, Shiqi Zhao, Hui Li, Yike Wang, Shuang Lu, Xinwen Dong, Jing Zhao, Shengzhu Yu, Minghui Li, Yue Li
Chronic obstructive sleep apnea (OSA) may promote the development of atrial fibrillation (AF) by inducing atrial electrical and structural remodeling as well as autonomic nerve hyperinnervation. Here, we investigated the roles of metoprolol in regulation of atrial remodeling induced by chronic OSA. A canine model of chronic OSA was established by stopping the ventilator and closing the airway for 4 h/day every other day for 12 weeks, while metoprolol (5 mg·kg-1·day-1) was continuously administered. Using that model, we observed that increases in sympathetic sprouting and atrial structural remodeling were sharply inhibited by metoprolol...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091865/the-role-of-sirt1-in-diabetic-retinopathy
#6
REVIEW
Hedyieh Karbasforooshan, Gholamreza Karimi
The prevalence of diabetes mellitus (DM), has been increasing worldwide. Diabetic retinopathy (DR) is the most common microvascular complication in diabetes. It is a multifactorial disease that occurs primarily through the long-term detrimental effects of hyperglycemia. The pathogenesis of DR is complex, including inflammation, oxidative stress and advanced glycation end products (AGES). SIRT1 is a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase that removes acetyl groups from proteins which can be implicated in DR...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29070475/-effect-of-resveratrol-on-forelimb-grip-strength-and-myofibril-structure-in-aged-rats
#7
Zhi-Yin Liao, Ke-Xiang Zhao, Qian Xiao
OBJECTIVE: To observe the effect of resveratrol on muscle mass, forelimb grip strength, myofibril structure and AMPK/sirt1 pathway in skeletal muscles of aged rats. METHODS: Twenty aged (25 months old) SD rats were randomly divided into aged control group and resveratrol treatment group (10 in each group) with 10 young (6 months old) rats served as the young control group. In resveratrol treatment group, the rats were treated with resveratrol (mixed in chow) for 6 weeks...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29068127/the-preventive-effects-of-edible-folic-acid-on-cardiomyocyte-apoptosis-and-survival-in-early-onset-triple-transgenic-alzheimer-s-disease-model-mice
#8
Kuan-Ho Lin, Chih-Hao Chiu, Wei-Wen Kuo, Da-Tong Ju, Chia-Yao Shen, Ray-Jade Chen, Chien-Chung Lin, Vijaya Padma Viswanadha, Jian-Sheng Liu, Rwei-Fen S Huang, Chih-Yang Huang
In recent years, neuropathological and epidemiological studies have indicated an association between Alzheimer's disease (AD) and several cardiovascular risk factors. In this study, the cardio-protective effects of folic acid (FA) in early stage AD was elucidated using a triple-transgenic (3xTg) Alzheimer's mouse model. Eleven-month-old C57BL/6 mice and 3xTg mice were assigned to five groups. During the four-month treatment period, the low-FA treatment group received FA through their diet, and the high-FA treatment groups received 3 mg/dl folate in drinking water and were also gastric-fed 1...
October 25, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29067115/advanced-glycation-end-products-and-lipopolysaccharides-stimulate-interleukin-6-secretion-via-the-rage-tlr4-nf-%C3%AE%C2%BAb-ros-pathways-and-resveratrol-attenuates-these-inflammatory-responses-in-mouse-macrophages
#9
Ayaka Ohtsu, Yui Shibutani, Kotomi Seno, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
Macrophages are essential for regulating the physiology of pregnancy; however, excessive inflammatory responses to macrophages, induced by infection and/or endogenous danger signals, may potentially result in complications during pregnancy. Advanced glycation end-products (AGE) and lipopolysaccharides (LPS) are known to induce inflammation and are associated with adverse developmental outcomes. The aim of the present study was to examine the effect of AGE and LPS on cytokines in the J774 murine macrophage cell line and the potential effect of resveratrol on AGE- and LPS-induced inflammation in macrophages...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29058611/adiponectin-is-required-for-maintaining-normal-body-temperature-in-a-cold-environment
#10
Qiong Wei, Jong Han Lee, Hongying Wang, Odelia Y N Bongmba, Chia-Shan Wu, Geetali Pradhan, Zilin Sun, Lindsey Chew, Mandeep Bajaj, Lawrence Chan, Robert S Chapkin, Miao-Hsueh Chen, Yuxiang Sun
BACKGROUND: Thermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated thermogenesis, the role of adiponectin in thermogenesis is not clear. In this study, we investigated the role of adiponectin in thermogenesis using adiponectin-null mice (Adipoq (-/-)). METHODS: Body composition was measured using EchoMRI. Metabolic parameters were determined by indirect calorimetry...
October 23, 2017: BMC Physiology
https://www.readbyqxmd.com/read/29057795/the-effect-of-piceatannol-from-passion-fruit-passiflora-edulis-seeds-on-metabolic-health-in-humans
#11
Munehiro Kitada, Yoshio Ogura, Hiroko Maruki-Uchida, Masahiko Sai, Taeko Suzuki, Keizo Kanasaki, Yuna Hara, Hiromi Seto, Yuka Kuroshima, Itaru Monno, Daisuke Koya
Animal studies have shown the beneficial effects of piceatannol on metabolic health; however, there is a lack of human studies designed to examine these effects. The objective of this study was to investigate the effects of piceatannol on metabolic health in humans. This randomized, placebo-controlled study was conducted on 39 subjects, including 10 overweight men and 9 overweight women (BMI ≥ 25), as well as 10 non-overweight men and 10 non-overweight women (BMI < 25). Subjects received piceatannol (20 mg/day) or placebo capsules for eight weeks in a random order...
October 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29036449/resveratrol-attenuates-bone-cancer-pain-through-regulating-the-expression-levels-of-asic3-and-activating-cell-autophagy
#12
Haili Zhu, Jieqiong Ding, Ji Wu, Tingting Liu, Jing Liang, Qiong Tang, Ming Jiao
Bone cancer pain (BCP) is one of the most common pains in patients with malignant cancers. The mechanism underlying BCP is largely unknown. Our previous studies and the increasing evidence both have shown that acid-sensing ion channels 3 (ASIC3) is an important protein in the pathological pain state in some pain models. We hypothesized that the expression change of ASIC3 might be one of the factors related to BCP. In this study, we established the BCP model through intrathecally injecting rat mammary gland carcinoma cells (MRMT-1) into the left tibia of Sprague-Dawley female rats, and found that the BCP rats showed bone destruction, increased mechanical pain sensitivities and up-regulated ASIC3 protein expression levels in L4-L6 dorsal root ganglion...
November 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29032153/metformin-overcomes-high-glucose-induced-insulin-resistance-of-podocytes-by-pleiotropic-effects-on-sirt1-and-ampk
#13
Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Patrycja Rachubik, Maria Szrejder, Stefan Angielski, Agnieszka Piwkowska
Podocyte insulin sensitivity is critical for glomerular function, and the loss of appropriate insulin signaling leads to alterations and disorders featuring diabetic nephropathy. Energy-sensing pathways, such as AMP-dependent protein kinase (AMPK) and protein deacetylase SIRT1, have been shown to play an important role in insulin resistance. The absence of a stimulating effect of insulin on glucose uptake into podocytes after exposure to hyperglycemic conditions has been demonstrated to be related to a decreased level and activity of SIRT1 protein, leading to reduced AMPK phosphorylation...
October 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29030114/impairment-of-energy-sensors-sirt1-and-ampk-in-lipid-induced-inflamed-adipocyte-is-regulated-by-fetuin-a
#14
Mrittika Chattopadhyay, Sandip Mukherjee, Subhendu K Chatterjee, Dipanjan Chattopadhyay, Snehasis Das, Subeer S Majumdar, Satinath Mukhopadhyay, Sutapa Mukherjee, Samir Bhattarcharya
Although several reports demonstrated that accumulation of excess lipid in adipose tissue produces defects in adipocyte which leads to the disruption of energy homeostasis causing severe metabolic problems, underlying mechanism of this event remains yet unclear. Here we demonstrate that FetuinA (FetA) plays a critical role in the impairment of two metabolic sensors, SIRT1 and AMPK, in inflamed adipocytes of high fat diet (HFD) mice. A linear increase in adipocyte hypertrophy from 10 to 16 week was in tandem with the increase in FetA and that coincided with SIRT1 cleavage and decrease in pAMPK which adversely affects PGC1α activation...
October 10, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29027961/dosis-facit-sanitatem-concentration-dependent-effects-of-resveratrol-on-mitochondria
#15
REVIEW
Corina T Madreiter-Sokolowski, Armin A Sokolowski, Wolfgang F Graier
The naturally occurring polyphenol, resveratrol (RSV), is known for a broad range of actions. These include a positive impact on lifespan and health, but also pro-apoptotic anti-cancer properties. Interestingly, cell culture experiments have revealed a strong impact of RSV on mitochondrial function. The compound was demonstrated to affect mitochondrial respiration, structure and mass of mitochondria as well as mitochondrial membrane potential and, ultimately, mitochondria-associated cell death pathways. Notably, the mitochondrial effects of RSV show a very strict and remarkable concentration dependency: At low concentrations, RSV (<50 μM) fosters cellular antioxidant defense mechanisms, activates AMP-activated protein kinase (AMPK)- and sirtuin 1 (SIRT1)-linked pathways and enhances mitochondrial network formation...
October 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29018142/adiponectin-has-a-pivotal-role-in-the-cardioprotective-effect-of-cp-3-iv-a-selective-cd36-azapeptide-ligand-after-transient-coronary-artery-occlusion-in-mice
#16
David N Huynh, Valérie L Bessi, Liliane Ménard, Jérôme Piquereau, Caroline Proulx, Maria Febbraio, William D Lubell, André C Carpentier, Yan Burelle, Huy Ong, Sylvie Marleau
CD36 is a multiligand receptor involved in lipid metabolism. We investigated the mechanisms underlying the cardioprotective effect of CP-3(iv), an azapeptide belonging to a new class of selective CD36 ligands. The role of CP-3(iv) in mediating cardioprotection was investigated because CD36 signaling leads to activation of peroxisome proliferator-activated receptor-γ, a transcriptional regulator of adiponectin. CP-3(iv) pretreatment reduced infarct size by 54% and preserved hemodynamics in C57BL/6 mice subjected to 30 min coronary ligation and reperfusion but had no effect in CD36-deficient mice...
October 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28992589/epigallocatechin-3-gallate-promotes-healthy-lifespan-through-mitohormesis-during-early-to-mid-adulthood-in-caenorhabditis-elegans
#17
Li-Gui Xiong, Yi-Jun Chen, Jie-Wen Tong, Yu-Shun Gong, Jian-An Huang, Zhong-Hua Liu
The green tea polyphenol epigallocatechin-3-gallate (EGCG) is widely consumed as a dietary supplement. Its potential properties include slowing aging and extending lifespan, although how exactly this is achieved remains unclear. Here, we report that EGCG promoted healthy lifespan in Caenorhabditis elegans when administered throughout or only at early-to-mid adulthood. Specifically, EGCG extended lifespan in an inverted U-shaped dose-response manner. The life-extending mechanism was stimulated by EGCG-induced production of reactive oxygen species (ROS)...
September 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/28973994/silibinin-restores-nad%C3%A2-%C2%BA-levels-and-induces-the-sirt1-ampk-pathway-in-non-alcoholic-fatty-liver
#18
Federico Salomone, Ignazio Barbagallo, Justyna Godos, Vincenzo Lembo, Walter Currenti, Diana Cinà, Roberto Avola, Nicolantonio D'Orazio, Filomena Morisco, Fabio Galvano, Giovanni Li Volti
Nicotinamide adenine dinucleotide (NAD⁺) homeostasis is emerging as a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and is tightly linked to the SIRT1/5'-AMP-activated protein kinase (AMPK) pathway. Silibinin, the main component of silymarin, has been proposed as a nutraceutical for the treatment of NAFLD. In this study, we aimed to identify whether silibinin may influence the NAD⁺/SIRT1 axis. To this end, C57BL/6 mice were fed a high fat diet (HFD) for 16 weeks, and were treated with silibinin or vehicle during the last 8 weeks...
September 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28970491/rev1-contributes-to-proper-mitochondrial-function-via-the-parp-nad-sirt1-pgc1%C3%AE-axis
#19
Nima Borhan Fakouri, Jon Ambæk Durhuus, Christine Elisabeth Regnell, Maria Angleys, Claus Desler, Mahdi Hasan- Olive, Ana Martín-Pardillos, Anastasia Tsaalbi-Shtylik, Kirsten Thomsen, Martin Lauritzen, Vilhelm A Bohr, Niels de Wind, Linda Hildegard Bergersen, Lene Juel Rasmussen
Nucleic acids, which constitute the genetic material of all organisms, are continuously exposed to endogenous and exogenous damaging agents, representing a significant challenge to genome stability and genome integrity over the life of a cell or organism. Unrepaired DNA lesions, such as single- and double-stranded DNA breaks (SSBs and DSBs), and single-stranded gaps can block progression of the DNA replication fork, causing replicative stress and/or cell cycle arrest. However, translesion synthesis (TLS) DNA polymerases, such as Rev1, have the ability to bypass some DNA lesions, which can circumvent the process leading to replication fork arrest and minimize replicative stress...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28966618/sirt1-adenosine-monophosphate-activated-protein-kinase-%C3%AE-signaling-enhances-macrophage-polarization-to-an-anti-inflammatory-phenotype-in-rheumatoid-arthritis
#20
So Youn Park, Sung Won Lee, Sang Yeob Lee, Ki Whan Hong, Sun Sik Bae, Koanhoi Kim, Chi Dae Kim
Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA). Macrophages of the M1 phenotype act as pro-inflammatory mediators in synovium, whereas those of the M2 phenotype suppress inflammation and promote tissue repair. SIRT1 is a class 3 histone deacetylase with anti-inflammatory characteristics. However, the role played by SIRT1 in macrophage polarization has not been defined in RA. We investigated whether SIRT1 exerts anti-inflammatory effects by modulating M1/M2 polarization in macrophages from RA patients...
2017: Frontiers in Immunology
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