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https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#1
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667375/core-curriculum-to-facilitate-the-expansion-of-a-rheumatology-practice-to-include-nurse-practitioners-and-physician-assistants
#2
Benjamin J Smith, Marcy B Bolster, Barbara Slusher, Christine Stamatos, Jeanne R Scott, Heather Benham, Salahuddin Kazi, Elizabeth A Schlenk, Daniel E Schaffer, Vikas Majithia, Calvin R Brown, Joan M von Feldt, Joseph Flood, David M Haag, Karen L Smarr
OBJECTIVE: Due to an aging population, increasing prevalence of rheumatic disease, and a growing supply and demand gap of rheumatology providers, innovative solutions are needed to meet the needs of persons with rheumatic conditions. Nurse practitioners (NPs) and physician assistants (PAs) have been identified as a group of health professionals who could help address the workforce shortage. The Executive Committee of the Association of Rheumatology Health Professionals (ARHP), a division of the American College of Rheumatology (ACR), charged a task force to facilitate the preparation of NPs/PAs to work in a rheumatology practice setting...
April 17, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29667191/herbal-medicine-containing-aristolochic-acid-and-the-risk-of-hepatocellular-carcinoma-in-patients-with-hepatitis-b-virus-infection
#3
Chi-Jen Chen, Yao-Hsu Yang, Meng-Hung Lin, Chuan-Pin Lee, Yu-Tse Tsan, Ming-Nan Lai, Hsiao-Yu Yang, Wen-Chao Ho, Pau-Chung Chen
It was suspected that aristolochic acid-induced mutations may be associated with hepatitis B virus (HBV), playing an important role in liver carcinogenesis. The purpose of this study was to investigate the association between the use of Chinese herbs containing aristolochic acid and the risk of hepatocellular carcinoma (HCC) among HBV-infected patients. We conducted a retrospective, population-based, cohort study on patients older than 18 years who had a diagnosis of HBV infection between January 1, 1997 and December 31, 2010 and had visited traditional Chinese medicine clinics before one year before the diagnosis of HCC or the censor dates...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29667044/germline-variants-in-pancreatic-cancer-patients-with-a-personal-or-family-history-of-cancer-fulfilling-the-revised-bethesda-guidelines
#4
Akihiro Ohmoto, Chigusa Morizane, Emi Kubo, Erina Takai, Hiroko Hosoi, Yasunari Sakamoto, Shunsuke Kondo, Hideki Ueno, Kazuaki Shimada, Shinichi Yachida, Takuji Okusaka
BACKGROUND: Pancreatic cancer (PC) is categorized as a neoplasm associated with Lynch syndrome; however, the precise proportion of PC patients harboring DNA mismatch repair genes (MMR genes) remains unclear, especially in the Asian population. METHODS: Among 304 Japanese patients with pathologically proven pancreatic ductal adenocarcinoma, we selected 20 (6.6%) patients with a personal or family history involving first- or second-degree relatives fulfilling the revised Bethesda guidelines (RBG), defined as RBG-compatible cases...
April 17, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29666958/ictal-interictal-continuum-patterns
#5
REVIEW
Gamaleldin M Osman, Davi F Araújo, Carolina B Maciel
PURPOSE OF REVIEW: To present data available on the epidemiology and significance of rhythmic and periodic patterns that lie on the ictal interictal continuum and propose an algorithm for the clinical approach to patients exhibiting these patterns. RECENT FINDINGS: There is accumulating evidence on the prognostic implications of various rhythmic and periodic patterns in the critically ill population. These patterns are not only associated with increased seizure risk but have also been associated with worse outcome and increased long-term risk of epilepsy in recent studies...
April 18, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29666948/epidemiology-of-hip-fracture-in-belarus-development-of-a-country-specific-frax-model-and-its-comparison-to-neighboring-country-models
#6
H Ramanau, I Chernyanin, E Rudenka, O Lesnyak, A Zakroyeva, J P Bilezikian, H Johansson, N C Harvey, E V McCloskey, J A Kanis
Fracture probabilities resulting from the newly generated FRAX model for Belarus based on regional estimates of the hip fracture incidence were compared with FRAX models of neighboring countries. Differences between the country-specific FRAX patterns and the rank orders of fracture probabilities were modest. OBJECTIVE: This paper describes the epidemiology of hip fractures in Belarus that was used to develop the country-specific fracture prediction FRAX® tool and illustrates its features compared to models for the neighboring countries of Poland, Russia, and Lithuania...
April 17, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29666919/prevalence-of-vitamin-d-insufficiency-and-evidence-for-disease-prevention-in-the-older-population
#7
REVIEW
Julia Kühn, Paula Trotz, Gabriele I Stangl
The prevalence of vitamin D insufficiency, usually assessed by the analysis of circulating 25-hydroxyvitamin D (25[OH])D), is very high in the aging German population. An important factor that reduces endogenous vitamin D synthesis in older persons is physical inactivity or care-dependency that limits the time spent outside. Additionally, it has been suggested that the age-dependent decline in the glomerular filtration rate is associated with a reduced production of bioactive calcitriol. As this phenomenon is not detectable by the assessment of 25(OH)D, it is necessary to analyze the level of parathyroid hormone as a marker of calcitriol function...
April 17, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29666782/new-perspectives-on-diagnosis-and-therapy-of-malignant-pleural-mesothelioma
#8
REVIEW
Marika Rossini, Paola Rizzo, Ilaria Bononi, Anthony Clementz, Roberto Ferrari, Fernanda Martini, Mauro G Tognon
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons per million of the general population, leading to thousands of deaths every year worldwide. To date, the MPM is mostly associated with occupational asbestos exposure. Asbestos represents the predominant etiological factor, with approximately 70% of cases of MPM with well-documented occupational exposure to asbestos, with the exposure time, on average greater than 40 years...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29666626/next-generation-immune-repertoire-sequencing-as-a-clue-to-elucidate-the-landscape-of-immune-modulation-by-host-gut-microbiome-interactions
#9
Tatsuo Ichinohe, Takahiko Miyama, Takakazu Kawase, Yasuko Honjo, Kazutaka Kitaura, Hiroyuki Sato, Tadasu Shin-I, Ryuji Suzuki
The human immune system is a fine network consisted of the innumerable numbers of functional cells that balance the immunity and tolerance against various endogenous and environmental challenges. Although advances in modern immunology have revealed a role of many unique immune cell subsets, technologies that enable us to capture the whole landscape of immune responses against specific antigens have been not available to date. Acquired immunity against various microorganisms including host microbiome is principally founded on T cell and B cell populations, each of which expresses antigen-specific receptors that define a unique clonotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29666603/long-term-factors-associated-with-falls-and-fractures-poststroke
#10
Emma J Foster, Raphae S Barlas, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
Background: Risk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke. Methods: Data from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003-2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1-3, 3-5, and 0-10 years follow-up)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29666255/digitizing-omics-profiles-by-divergence-from-a-baseline
#11
Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole Pagane, Anching Lien, Tejasvi Matam, Elana J Fertig, Nathan D Price, Laurent Younes, Luigi Marchionni, Donald Geman
Data collected from omics technologies have revealed pervasive heterogeneity and stochasticity of molecular states within and between phenotypes. A prominent example of such heterogeneity occurs between genome-wide mRNA, microRNA, and methylation profiles from one individual tumor to another, even within a cancer subtype. However, current methods in bioinformatics, such as detecting differentially expressed genes or CpG sites, are population-based and therefore do not effectively model intersample diversity...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666138/increase-in-assisted-suicide-in-switzerland-did-the-socioeconomic-predictors-change-results-from-the-swiss-national-cohort
#12
Nicole Steck, Christoph Junker, Marcel Zwahlen
OBJECTIVE: To determine whether the strong increase in assisted suicides in Switzerland since 2008 is linked to a shift in the socioeconomic factors associated with assisted suicide and its related diagnoses. METHODS: In a population-based longitudinal study, we investigated assisted suicides in Switzerland over the period 2003-2014. Two groups of younger (25-64 years) and older (65-94 years) persons were analysed separately and compared. We calculated crude rates and used Cox proportional hazard and logistic regression models to examine associations of assisted dying with gender, marital status, education, religion, neighbourhood socioeconomic status and other variables, and investigated trends over time...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665755/incremental-direct-medical-costs-of-systemic-lupus-erythematosus-patients-in-the-years-preceding-diagnosis-a-general-population-based-study
#13
N McCormick, C A Marra, M Sadatsafavi, J A Aviña-Zubieta
Objective We estimated the incremental (extra) direct medical costs of a population-based cohort of newly diagnosed systemic lupus erythematosus (SLE) for five years before and after diagnosis, and the impact of sex and socioeconomic status (SES) on pre-index costs for SLE. Methods We identified all adults newly diagnosed with SLE over 2001-2010 in British Columbia, Canada, and obtained a sample of non-SLE individuals from the general population, matched on sex, age, and calendar-year of study entry. We captured costs for all outpatient encounters, hospitalisations, and dispensed medications each year...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29665517/depression-and-impulsiveness-among-soldiers-who-died-by-suicide-a-psychological-autopsy-study
#14
Leah Shelef, Neta Korem, Nirit Yavnai, Rinat Yedidya, Keren Ginat, Golan Shahar, Assaf Yacobi
INTRODUCTION: Despite the accumulated knowledge about suicide, suicidal acts remain difficult to predict, and many suicides are acted out impulsively. METHODS: We performed a psychological autopsy study based on inquiries about the deaths of all male soldiers aged 18-21 years who served in the Israeli army and died by suicide between 2009 and 2013 (n = 69). The study population was first divided into two groups: those who had depressive disorder (n = 31); and those who did not (n = 38)...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29665463/long-term-exposure-to-wind-turbine-noise-at-night-and-risk-for-diabetes-a-nationwide-cohort-study
#15
Aslak Harbo Poulsen, Ole Raaschou-Nielsen, Alfredo Peña, Andrea N Hahmann, Rikke Baastrup Nordsborg, Matthias Ketzel, Jørgen Brandt, Mette Sørensen
Focus on renewable energy sources and reduced unit costs has led to increased number of wind turbines (WTs). WT noise (WTN) is reported to be highly annoying at levels from 30 to 35 dB and up, whereas for traffic noise people report to be highly annoyed from 40 to 45 dB and up. This has raised concerns as to whether WTN may increase risk for major diseases, as exposure to traffic noise has consistently been associated with increased risk of cardiovascular disease and diabetes. We identified all Danish dwellings within a radius of 20 WT heights and 25% of all dwellings within 20-40 WT heights from a WT...
April 14, 2018: Environmental Research
https://www.readbyqxmd.com/read/29665462/urinary-phthalate-metabolites-and-environmental-phenols-in-university-students-in-south-china
#16
Xue-Mei Zhang, Xiang-Ying Lou, Liu-Hong Wu, Cong Huang, Da Chen, Ying Guo
In China, university students have unique lifestyles compared with the rest of the youth population, as they are almost entirely isolated in campuses. The number of university students is large, and since students represent the future of human reproduction, exposure to environmental endocrine disruptors (EEDs) may have a large impact on society. In this study, levels of several EEDs, including phthalate metabolites, parabens, bisphenol A (BPA) and its analogues, triclosan (TCS), and benzophenone-3, were determined in 169 urine samples collected from university students in Guangzhou, South China...
April 14, 2018: Environmental Research
https://www.readbyqxmd.com/read/29665174/a-managed-alcohol-program-in-sydney-australia-acceptability-cost-savings-and-non-beverage-alcohol-use
#17
Nadine Ezard, Michael E Cecilio, Brendan Clifford, Eileen Baldry, Lucy Burns, Carolyn A Day, Marian Shanahan, Kate Dolan
INTRODUCTION AND AIMS: Managed alcohol programs (MAPs) are a novel harm reduction intervention for people who experience long-term homelessness and severe long-term alcohol dependence. MAPs provide regulated amounts of alcohol onsite under supervision. Preliminary international evidence suggests that MAPs are associated with improvements such as reduced non-beverage alcohol consumption and decreases in some alcohol-related harms. There are currently no MAPs in Australia. We aimed to assess the feasibility of a MAP in inner-Sydney...
April 17, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29665085/carpal-tunnel-release-lifetime-prevalence-annual-incidence-and-risk-factors
#18
Mohammad-Hossein Pourmemari, Markku Heliövaara, Eira Viikari-Juntura, Rahman Shiri
INTRODUCTION: We estimated the lifetime prevalence and incidence of carpal tunnel release (CTR), and identified risk factors for CTR. METHODS: Study population consisted of individuals aged >30 years living in Finland during 2000-2001 (N=6256), and was linked to the Finnish Hospital Discharge Register from 2000 to 2011. RESULTS: Lifetime prevalence of CTR was 3.1% and incidence rate was 1.73 per 1000 person-years. Female sex (adjusted hazard ratio (HR)=1...
April 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29665075/the-characteristics-of-transferrin-variants-by-carbohydrate-deficient-transferrin-tests-using-capillary-zone-electrophoresis
#19
Gilsung Yoo, Juwon Kim, Kap Joon Yoon, Jong-Han Lee
BACKGROUND: Transferrin is the major plasma transport protein for iron. We aimed to investigate the characteristics of transferrin variant by carbohydrate-deficient transferrin (CDT) test using capillary zone electrophoresis. METHODS: We retrospectively analyzed the CDT tests of 2449 patients from March 2009 to May 2017 at a tertiary hospital in Korea. CDT was quantified using a Capillarys 2 system (Sebia, Lisses, France) by capillary zone electrophoresis. The characteristics of variant transferrin patterns using electropherogram of CDT tests were analyzed...
April 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29665006/police-contacts-arrests-and-decreasing-self-control-and-personal-responsibility-among-female-adolescents
#20
Alison E Hipwell, Joseph Beeney, Feifei Ye, Sabrina H Gebreselassie, Madeline R Stalter, Dyuti Ganesh, Kate Keenan, Stephanie D Stepp
BACKGROUND: Female involvement in the juvenile justice system (JJS) has increased rapidly in recent years. Although deficits in self-control and responsibility are associated with delinquency and higher rates of police contacts and arrests, much of this research has focused on males and/or selected samples of youth who already have a history of JJS involvement. Furthermore, little is known about the extent to which police contacts and arrests may disrupt normative psychosocial maturation...
April 17, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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