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https://www.readbyqxmd.com/read/28733868/impact-of-age-on-the-risk-of-advanced-colorectal-neoplasia-in-a-young-population-an-analysis-using-the-predicted-probability-model
#1
Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Mi Yeon Lee, Dong Il Park
BACKGROUND: The incidence of colorectal cancer is decreasing in adults aged ≥50 years and increasing in those aged <50 years. AIMS: We aimed to establish risk stratification model for advanced colorectal neoplasia (ACRN) in persons aged <50 years. METHODS: We reviewed the records of participants who had undergone a colonoscopy as part of a health examination at two large medical examination centers in Korea. By using logistic regression analysis, we developed predicted probability models for ACRN in a population aged 30-49 years...
July 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28733840/identification-of-a%C3%A2-rare-coch-mutation-by-whole-exome-sequencing-implications-for-personalized-therapeutic-rehabilitation-in-an-austrian-family-with-non-syndromic-autosomal-dominant-late-onset-hearing-loss
#2
Thomas Parzefall, Alexandra Frohne, Martin Koenighofer, Andreas Kirchnawy, Berthold Streubel, Christian Schoefer, Wolfgang Gstoettner, Klemens Frei, Trevor Lucas
BACKGROUND: Non-syndromic autosomal dominant hearing impairment is characteristically postlingual in onset. Genetic diagnostics are essential for genetic counselling, disease prognosis and understanding of the molecular mechanisms of disease. To date, 36 causative genes have been identified, many in only individual families. Gene selection for genetic screening by traditional methods and genetic diagnosis in autosomal dominant patients has therefore been fraught with difficulty. Whole-exome sequencing provides a powerful tool to analyze all protein-coding genomic regions in parallel, thus allowing the comprehensive screening of all known genes and associated alterations...
July 21, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28733716/osteosarcopenia-where-bone-muscle-and-fat-collide
#3
REVIEW
H P Hirschfeld, R Kinsella, G Duque
As the world's population ages, the prevalence of chronic diseases increases. Sarcopenia and osteoporosis are two conditions that are associated with aging, with similar risk factors that include genetics, endocrine function, and mechanical factors. Additionally, bone and muscle closely interact with each other not only anatomically, but also chemically and metabolically. Fat infiltration, a phenomenon observed in age-related bone and muscle loss, is highly prevalent and more severe in sarcopenic and osteoporotic subjects...
July 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28733532/cancer-risk-in-patients-with-candidiasis-a-nationwide-population-based-cohort-study
#4
Li-Min Chung, Ji-An Liang, Cheng-Li Lin, Li-Min Sun, Chia-Hung Kao
BACKGROUND: Candidiasis and certain types of cancer are related to immunocompromised status. This study aimed to evaluate whether Candida infection (CI) is associated with subsequent cancer risk in Taiwan. METHODS: Data from the National Health Insurance system of Taiwan were used to evaluate the association between CI and cancer risk. The CI cohort comprised 34,829 patients. Each patient was randomly frequency matched with one person from the general population without CI on the basis of age, sex, year of index date of CI diagnosis, and other characteristics to generate the control group...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733374/the-fallacy-of-average-how-using-hba1c-alone-to-assess-glycemic-control-can-be-misleading
#5
Roy W Beck, Crystal G Connor, Deborah M Mullen, David M Wesley, Richard M Bergenstal
HbA1c is a valuable metric for comparing treatment groups in a randomized trial, for assessing glycemic trends in a population over time, or for cross-sectional comparisons of glycemic control in different populations. However, what is not widely appreciated is that HbA1c may not be a good indicator of an individual patient's glycemic control because of the wide range of mean glucose concentrations and glucose profiles that can be associated with a given HbA1c level. To illustrate this point, we plotted mean glucose measured with continuous glucose monitoring (CGM) versus central laboratory-measured HbA1c in 387 participants in three randomized trials, showing that not infrequently HbA1c may underestimate or overestimate mean glucose, sometimes substantially...
August 2017: Diabetes Care
https://www.readbyqxmd.com/read/28733184/medication-use-and-its-potential-impact-on-the-oral-health-status-of%C3%A2-nursing-home-residents-in-flanders-belgium
#6
Barbara Janssens, Mirko Petrovic, Wolfgang Jacquet, Jos M G A Schols, Jacques Vanobbergen, Luc De Visschere
BACKGROUND: Polypharmacy is considered the most important etiologic factor of hyposalivation, which in turn can initiate oral health problems. OBJECTIVES: To describe the medication use of nursing home residents, to identify the medications related to hyposalivation and to find possible associations between the different classes of medication, the number of medications, and the oral health status of the residents. DESIGN: A cross-sectional study...
July 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28733154/community-pharmacists-knowledge-of-alzheimer-disease-care-in-high-and-low-income-chicago
#7
Marketa Marvanova, Paul Jacob Henkel
OBJECTIVES: This pilot study examined community pharmacists' knowledge to provide care and services for persons with Alzheimer disease (AD) and area income-based disparities in knowledge and availability of cognitive enhancers. METHODS: A cross-sectional telephone survey of pharmacies (n = 137) in high- and low-income areas in Chicago was conducted on pharmacists' degree, experience, and continuing education, as well as knowledge of AD disease and treatment expectations, adverse effects (AEs) of donepezil, and self-care recommendations for insomnia...
July 18, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28732008/falls-non-accidental-falls-and-syncope-in-community-dwelling-adults-aged-50-years-and-older-implications-for-cardiovascular-assessment
#8
Jaspreet Bhangu, Bellinda L King-Kallimanis, Orna A Donoghue, Laura Carroll, Rose Anne Kenny
OBJECTIVES: To calculate the prevalence of all falls, non-accidental falls and syncope in an older population and characterize cardiovascular risk profiles. DESIGN: Prospective, longitudinal cohort study. SETTING: The first two waves of data from the Irish Longitudinal Study on Ageing (TILDA). PARTICIPANTS: 8172 community-dwelling adults aged 50 years and older resident in the Republic of Ireland. MEASUREMENTS: Self-reported history of all falls, non-accidental falls and syncope in the year preceding the first two waves of data collection...
2017: PloS One
https://www.readbyqxmd.com/read/28731726/age-period-cohort-analysis-of-colorectal-cancer-service-members-aged-20-59-years-active-component-u-s-armed-forces-1997-2016
#9
Shauna Stahlman, Alexis Oetting
In the U.S. general population, incidence of colorectal cancer appears to be increasing in younger age groups since the mid-1980s. The objective of this report was to better understand the time-varying elements (age, period, and birth cohort effects) in the epidemiology of colorectal cancer among the active component of the U.S. Armed Forces. During 1997-2016, there were 1,108 incident cases of colorectal cancer among service members aged 20-59 years, corresponding to an overall incidence rate of 4.3 per 100,000 person-years (p-yrs)...
July 2017: MSMR
https://www.readbyqxmd.com/read/28731725/skin-and-soft-tissue-infections-active-component-u-s-armed-forces-2013-2016
#10
Shauna Stahlman, Valerie F Williams, Gi-Taik Oh, Eugene V Millar, Jason W Bennett
During the 4-year surveillance period, there were 282,571 incident cases of skin and soft tissue infection (SSTI) among active component U.S. military members diagnosed in inpatient or outpatient settings, corresponding to an overall incidence of 558.2 per 10,000 person-years (p-yrs). An additional 10,904 cases occurred in theater of operations (460.0 per 10,000 p-yrs). Approximately half (49.4%) were classified as "other SSTI" (e.g., folliculitis, impetigo); 45.9% were cellulitis/abscess; 4.6% were carbuncles/furuncles; and 0...
July 2017: MSMR
https://www.readbyqxmd.com/read/28731509/keeping-safe-continuous-glucose-monitoring-cgm-in-persons-with-type-1-diabetes-and-impaired-awareness-of-hypoglycaemia-a-qualitative-study
#11
A F Vloemans, C A J van Beers, M de Wit, W Cleijne, S M Rondags, P H Geelhoed-Duijvestijn, M H H Kramer, E H Serné, F J Snoek
AIM: To further our understanding of individual use and experience of continuous glucose monitoring (CGM) in adults with Type 1 diabetes and impaired awareness of hypoglycaemia, we conducted a qualitative study supplementary to a randomized controlled trial, using semi-structured interviews. METHODS: Twenty-three participants of the IN CONTROL trial were interviewed within 4 weeks after the last study visit. The interview centred around experiences of CGM, taking into account the person's expectations prior to the trial...
July 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28730628/acute-hepatic-porphyria-and-cancer-risk-a-nationwide-cohort-study
#12
C M Baravelli, S Sandberg, A K Aarsand, R M Nilsen, M C Tollånes
BACKGROUND: Acute hepatic porphyria (AHP) is considered to be a risk factor for primary liver cancer (PLC), but varying risk estimates have been published. OBJECTIVES: Our aim was to investigate the risk of PLC and other cancers in persons with AHP using a nationwide cohort design. Given that greater numbers of women than men tend to have manifest and more severe AHP, a further aim was to investigate sex differences in this risk. METHODS: The study sample consisted of all Norwegian residents aged 18 years or older during the period 2000-2011...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28730158/a-rapid-epidemiological-tool-to-measure-the-burden-of-norovirus-infection-and-disease-in-resource-limited-settings
#13
Daniel Olson, Molly M Lamb, Maria Renee Lopez, M Alejandra Paniagua-Avila, Alma Zacarias, Gabriela Samayoa-Reyes, Celia Cordon-Rosales, Edwin J Asturias
BACKGROUND: Rapid, cost-effective tools are needed to estimate the disease burden of acute gastroenteritis (AGE) and norovirus (NoV) in resource-limited settings. METHODS: Households with children (6 weeks-17 years) in rural Guatemala were randomly enrolled into 2 parallel AGE surveillance systems: (1) a prospective cohort, which included an enrollment visit followed by 1 year of prospective observation using a smartphone-based weekly symptom diary; and (2) 2 sequential cross-sectional rapid active sampling (RAS) surveys...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28729915/the-concomitant-association-of-thyroid-disorders-and-myasthenia-gravis
#14
Yu-Pei Lin, Usman Iqbal, Phung-Anh Nguyen, Md Mohaimenul Islam, Suleman Atique, Wen-Shan Jian, Yu-Chuan Jack Li, Chen-Ling Huang, Chung-Huei Hsu
BACKGROUND: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders. METHODS: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Patients with TD and MG were identified by referring to the ICD-9-CM codes...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28729325/risk-of-sarcoidosis-and-seropositive-rheumatoid-arthritis-from-occupational-silica-exposure-in-swedish-iron-foundries-a-retrospective-cohort-study
#15
Per Vihlborg, Ing-Liss Bryngelsson, Lena Andersson, Pål Graff
OBJECTIVE: To study the impact of occupational silica exposure on the incidence rates of sarcoidosis and rheumatoid arthritis (RA) in a cohort of exposed workers in Swedish iron foundries. DESIGN: The prevalence of sarcoidosis and RA in a cohort of silica exposed workers was compared with the prevalence in the general Swedish population in this register study. A mixed model was used to calculate silica exposure, and individual silica exposures were used to compute dose responses...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28729307/occupational-class-differences-in-long-sickness-absence-a-register-based-study-of-2-1-million-finnish-women-and-men-in-1996-2013
#16
Johanna Pekkala, Jenni Blomgren, Olli Pietiläinen, Eero Lahelma, Ossi Rahkonen
OBJECTIVES: Sickness absence is consistently higher in lower occupational classes, but attempts to analyse changes over time in socioeconomic differences are scarce. We examined trends in medically certified sickness absence by occupational class in Finland from 1996 to 2013 and assessed the magnitude and changes in absolute and relative occupational class differences. DESIGN: Population-based, repeated cross-sectional study. SETTING: A 70% random sample of Finns aged between 25 and 63 years in the years 1996-2013...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28729043/individualized-assessment-of-fracture-risk-contribution-of-osteogenomic-profile
#17
Tuan V Nguyen
Over the past decade, several genetic variants or genes for osteoporosis have been identified through genome-wide association studies and candidate gene association studies. These genetic variants are common in the general population but have modest effect sizes, with odds ratio ranging from 1.1 to 1.5. Thus, the utility of any single variant is limited. However, theoretical and empirical studies have suggested that a profiling of multiple variants that are associated with bone phenotypes (i.e., "osteogenomic profile") can improve the accuracy of fracture prediction and classification beyond that obtained by conventional clinical risk factors...
July 17, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28728918/financing-transformative-health-systems-towards-achievement-of-the-health-sustainable-development-goals-a-model-for-projected-resource-needs-in-67-low-income-and-middle-income-countries
#18
Karin Stenberg, Odd Hanssen, Tessa Tan-Torres Edejer, Melanie Bertram, Callum Brindley, Andreia Meshreky, James E Rosen, John Stover, Paul Verboom, Rachel Sanders, Agnès Soucat
BACKGROUND: The ambitious development agenda of the Sustainable Development Goals (SDGs) requires substantial investments across several sectors, including for SDG 3 (healthy lives and wellbeing). No estimates of the additional resources needed to strengthen comprehensive health service delivery towards the attainment of SDG 3 and universal health coverage in low-income and middle-income countries have been published. METHODS: We developed a framework for health systems strengthening, within which population-level and individual-level health service coverage is gradually scaled up over time...
July 14, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28728764/experiences-of-daily-life-among-adolescents-with-asthma-a-struggle-with-ambivalence
#19
Marina Jonsson, Marja Schuster, Jennifer L P Protudjer, Anna Bergström, Ann-Charlotte Egmar, Inger Kull
OBJECTIVE: There is limited knowledge about how adolescents with asthma view their disease in daily life and how these views impact on management. The aim of this study was to describe experiences of daily life, with particular focus on thoughts, feelings and management of adolescents with asthma. METHODS: In this qualitative study, data were obtained from 10 interviews with adolescents (aged 16-18 years) with asthma recruited from the Swedish population-based prospective birth cohort, BAMSE...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28728555/medical-homelessness-and-candidacy-women-transiting-between-prison-and-community-health-care
#20
Penelope Abbott, Parker Magin, Joyce Davison, Wendy Hu
BACKGROUND: Women in contact with the prison system have high health needs. Short periods in prison and serial incarcerations are common. Examination of their experiences of health care both in prison and in the community may assist in better supporting their wellbeing and, ultimately, decrease their risk of returning to prison. METHODS: We interviewed women in prisons in Sydney, Australia, using pre-release and post-release interviews. We undertook thematic analysis of the combined interviews, considering them as continuing narratives of their healthcare experiences...
July 20, 2017: International Journal for Equity in Health
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