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https://www.readbyqxmd.com/read/28654924/influence-of-intrinsic-and-lifestyle-factors-on-the-development-of-ige-sensitization
#1
Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: IgE sensitization is a prerequisite for the development of allergic symptoms. The investigation of factors influencing the development of IgE is therefore crucial for understanding the onset of allergic diseases. METHODS: This epidemiological study investigated personal, intrinsic, and lifestyle factors in a nonselected cohort of 501 Austrian adolescents (aged 12-21 years). IgE levels to 112 allergen molecules were analyzed in the serum of participants using the ImmunoCAP ISAC®...
June 28, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28654205/driving-toward-precision-medicine-for-acute-leukemias-are-we-there-yet
#2
Clement Chung, Hilary Ma
Despite recent progress in the understanding of the molecular basis of acute leukemias, treatment options for these diseases have not shown significant changes over the last few decades. In this review, we present a nonexhaustive key summary of the current cytogenetic and molecular changes associated with acute leukemias in disease prognostication and potential targeted therapies. An emerging paradigm is that many genetic or molecular alterations target similar signal transduction, transcriptional, and epigenetic pathways...
June 27, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28654016/salivary-immune-and-metabolic-marker-analysis-simma-a-diagnostic-test-to-predict-caries-risk
#3
Alex Mira, Alejandro Artacho, Anny Camelo-Castillo, Sandra Garcia-Esteban, Aurea Simon-Soro
By using ELISA and colorimetric tests, we have measured 25 compounds in individuals with and without dental caries at different time points of dental biofilm formation and time of the day. We find that some compounds appear to be affected by circadian rhythms, others by dental plaque maturity, and others show constant values during a 24 h period. Using univariate analysis and cross-validation techniques, we have selected six components measured at specific time points that maximize the diagnostic separation of health and disease conditions...
June 27, 2017: Diagnostics
https://www.readbyqxmd.com/read/28653123/pixel-level-deep-segmentation-artificial-intelligence-quantifies-muscle-on-computed-tomography-for-body-morphometric-analysis
#4
Hyunkwang Lee, Fabian M Troschel, Shahein Tajmir, Georg Fuchs, Julia Mario, Florian J Fintelmann, Synho Do
Pretreatment risk stratification is key for personalized medicine. While many physicians rely on an "eyeball test" to assess whether patients will tolerate major surgery or chemotherapy, "eyeballing" is inherently subjective and difficult to quantify. The concept of morphometric age derived from cross-sectional imaging has been found to correlate well with outcomes such as length of stay, morbidity, and mortality. However, the determination of the morphometric age is time intensive and requires highly trained experts...
June 26, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28653033/neuroticism-depression-and-anxiety-traits-exacerbate-the-state-of-cognitive-impairment-and-hippocampal-vulnerability-to-alzheimer-s-disease
#5
Valérie Zufferey, Alessia Donati, Julius Popp, Reto Meuli, Jérôme Rossier, Richard Frackowiak, Bogdan Draganski, Armin von Gunten, Ferath Kherif
INTRODUCTION: Certain personality traits are associated with higher risk of Alzheimer's disease, similar to cognitive impairment. The identification of biological markers associated with personality in mild cognitive impairment could advance the early detection of Alzheimer's disease. METHODS: We used hierarchical multivariate linear models to quantify the interaction between personality traits, state of cognitive impairment, and MRI biomarkers (gray matter brain volume, gray matter mean water diffusion) in the medial temporal lobe (MTL)...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28651846/molecular-basis-of-%C3%AE-thalassemia-and-potential-therapeutic-targets
#6
REVIEW
Swee Lay Thein
The remarkable phenotypic diversity of β thalassemia that range from severe anemia and transfusion-dependency, to a clinically asymptomatic state exemplifies how a spectrum of disease severity can be generated in single gene disorders. While the genetic basis for β thalassemia, and how severity of the anemia could be modified at different levels of its pathophysiology have been well documented, therapy remains largely supportive with bone marrow transplant being the only cure. Identification of the genetic variants modifying fetal hemoglobin (HbF) production in combination with α globin genotype provide some prediction of disease severity for β thalassemia but generation of a personalized genetic risk score to inform prognosis and guide management requires a larger panel of genetic modifiers yet to be discovered...
June 20, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28651224/patterns-of-everyday-functioning-in-preschool-children-born-preterm-and-at-term
#7
Anna Karin Andersson, Lene Martin, Katarina Strand Brodd, Lena Almqvist
BACKGROUND/AIM: Children born preterm are at risk of neonatal complications but the long-term consequences for everyday functioning is not well known. The study aimed to identify patterns of everyday functioning in preschool children born preterm and at term in relation to perinatal data, neonatal risk factors, behaviour, and socioeconomic status. Registry data and data from parent rated questionnaires were collected for 331 children. METHOD: A person-oriented approach with a cluster analysis was used...
June 23, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28650229/hiv-treatment-and-re-infection-beliefs-predict-sexual-risk-behavior-of-men-who-have-sex-with-men
#8
Hong-Ha M Truong, Robin Fatch, H Fisher Raymond, Willi McFarland
We examined whether beliefs about antiretroviral (ART) efficacy and reinfection prospectively predicted subsequent condomless anal intercourse (CAI). Men who have sex with men in San Francisco (N = 773) were recruited for a longitudinal study using time-location sampling. HIV-negative men were more likely to have sero-discordant receptive CAI and HIV-positive men were more likely to have sero-discordant insertive CAI if they previously reported these behaviors at baseline and reported less concern about HIV transmission due to ART...
June 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28647668/a-combined-marker-of-early-non-improvement-and-the-occurrence-of-melancholic-features-improve-the-treatment-prediction-in-patients-with-major-depressive-disorders
#9
Stefanie Wagner, André Tadić, Sibylle C Roll, Alice Engel, Nadine Dreimüller, Jan Engelmann, Klaus Lieb
BACKGROUND: Early Improvement of depressive symptoms within two weeks of antidepressant treatment is a highly sensitive but less specific predictor of later treatment outcome. The aim of this study was to identify clinical features at treatment initiation which are associated with early improvement and non-improvement as well as to identify variables predicting non-remission in patients showing an early improvement. METHODS: 889 patients with a major depressive episode according to DSM-IV who had participated in an antidepressant treatment trial served as study sample...
June 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28646861/c-terminal-fragment-of-agrin-caf-levels-predict-acute-kidney-injury-after-acute-myocardial-infarction
#10
Spyridon Arampatzis, Georgios Chalikias, Vasilios Devetzis, Stavros Konstantinides, Uyen Huynh-Do, Dimitrios Tziakas
BACKGROUND: Patients with acute myocardial infarction are at high risk for acute kidney injury. Novel biomarkers that can predict acute kidney injury in AMI may allow timely interventions. C-terminal fragment of agrin (CAF), a proteoglycan of the glomerular and tubular basement membrane, have been recently associated with rapid renal function deterioration and proximal tubular dysfunction. It is unknown whether elevated CAF levels may serve as a novel AKI biomarker in patients presenting with AMI...
June 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28645934/repeated-measurements-of-cardiac-biomarkers-in-atrial-fibrillation-and-validation-of-the-abc-stroke-score-over-time
#11
Ziad Hijazi, Bertil Lindahl, Jonas Oldgren, Ulrika Andersson, Johan Lindbäck, Christopher B Granger, John H Alexander, Bernard J Gersh, Michael Hanna, Veli-Pekka Harjola, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Cardiac biomarkers are independent risk markers in atrial fibrillation, and the novel biomarker-based ABC stroke score (age, biomarkers, and clinical history of prior stroke) was recently shown to improve the prediction of stroke risk in patients with atrial fibrillation. Our aim was to investigate the short-term variability of the cardiac biomarkers and evaluate whether the ABC stroke risk score provides a stable short-term risk estimate. METHODS AND RESULTS: According to the study protocol, samples were obtained at entry and also at 2 months in 4796 patients with atrial fibrillation followed for a median of 1...
June 23, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28645223/decline-in-literacy-and-incident-ad-dementia-among-community-dwelling-older-persons
#12
Lei Yu, Robert S Wilson, S Duke Han, Sue Leurgans, David A Bennett, Patricia A Boyle
OBJECTIVE: To quantify longitudinal change in financial and health literacy and examine the associations of declining literacy with incident Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI). METHOD: Data came from 799 participants of an ongoing cohort study. Literacy was measured using a battery of 32 questions. Clinical diagnoses were made annually following uniform structured procedures. The associations of declining literacy with incident AD dementia and MCI were tested using a joint model for longitudinal and time-to-event data...
June 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28642373/failure-of-falls-risk-screening-tools-to-predict-outcome-a-prospective-cohort-study
#13
Kristie J Harper, Annette D Barton, Glenn Arendts, Deborah G Edwards, Antonio C Petta, Antonio Celenza
OBJECTIVE: To compare the Falls Risk for Older Persons-Community Setting Screening Tool (FROP Com Screen) with the Two-Item Screening Tool in older adults presenting to the ED. METHODS: A prospective cohort study, comparing the efficacy of the two falls risk assessment tools by applying them simultaneously in a sample of hospital ED presentations. RESULTS: Two hundred and one patients over 65 years old were recruited. Thirty-six per cent reported falls in the 6-month follow-up period...
June 22, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28642100/jcl-roundtable-future-of-the-lipid-laboratory-using-the-laboratory-to-manage-the-patient-part-2
#14
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
May 25, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28641570/1h-post-load-blood-glucose-in-the-identification-of-proatherogenic-cardiometabolic-profile-in-obesity
#15
Djordje S Popovic, Dragana Tomic-Naglic, Milena Mitrovic, Zeljko Zivanovic, Bojan Vukovic, Edita Stokic
BACKGROUND AND AIM: Current data show that 1h oral glucose tolerance test (OGTT) blood glucose (1h-BG) might identify persons at increased risk of developing type 2 diabetes and cardiovascular diseases more precisely than fasting blood glucose (FBG) and 2h OGTT blood glucose (2h-BG). The aim of study was to determine whether is justified to use 1h-BG, instead of traditional blood glucose measurements, in cardiometabolic profiling of obese individuals. METHOD: Cross-sectional study enrolled 60 obese individuals without previous history of diabetes and other cardiometabolic disorders...
June 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28636673/evaluation-of-molecular-diagnostic-approaches-for-the-detection-of-braf-p-v600e-mutations-in-papillary-thyroid-cancer-clinical-implications
#16
Artur Kowalik, Aldona Kowalska, Agnieszka Walczyk, Renata Chodurska, Janusz Kopczyński, Magdalena Chrapek, Elżbieta Wypiórkiewicz, Małgorzata Chłopek, Liliana Pięciak, Danuta Gąsior-Perczak, Iwona Pałyga, Krzysztof Gruszczyński, Ewelina Nowak, Stanisław Góźdź
Differentiated papillary thyroid cancer (PTC) is the most common cancer of the endocrine system. PTC has a very good prognosis and a high 5 year survival rate; however, some patients are unresponsive to treatment, and their diagnosis eventually results in death. Recent efforts have focused on searching for prognostic and predictive factors that may enable treatment personalization and monitoring across the course of the disease. The presence of the BRAF mutation is considered to contribute to the risk of poor clinical course, according to American Thyroid Association (ATA) recommendations...
2017: PloS One
https://www.readbyqxmd.com/read/28635195/a-study-to-estimate-prevalence-and-risk-factors-of-obstructive-sleep-apnoea-syndrome-in-a-semi-urban-indian-population
#17
Abhijeet Singh, Rajendra Prasad, Rajiv Garg, Surya Kant, Giridhar B Hosmane, Abhisek Dubey, Abhisek Agarwal, Ram Kishun Verma
Obstructive Sleep Apnea Syndrome (OSAS) has been recognised as a major cause of morbidity and mortality in developing countries like India. There is still a paucity of Indian studies regarding the prevalence of OSAS. The current single centre prospective cross-sectional study was undertaken to know prevalence estimates for key symptoms and features that can indicate the presence of OSAS in an Indian population. A survey was conducted on subjects with age groups ≥ 25 years at King George's Medical University, Lucknow, Uttar Pradesh, India from August 2009 to July 2011...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28633023/the-insular-cortex
#18
Nadine Gogolla
Whether you see the person you are in love with, try to listen to your own heartbeat, suffer from a headache, or crave for a chocolate cookie, one part of your brain is sure to increase its activity strongly: the insular cortex. The insular cortex, or 'insula' for short, is part of the cerebral cortex. J.C. Reil, a German neurologist, first named this brain structure in the early 19(th) century. Subsequent research findings have implicated the insula in an overwhelming variety of functions ranging from sensory processing to representing feelings and emotions, autonomical and motor control, risk prediction and decision-making, bodily- and self-awareness, and complex social functions like empathy...
June 19, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28632478/sexual-risk-behaviors-and-predictors-of-inconsistent-condom-use-among-crack-cocaine-users-in-the-french-overseas-territories-in-the-americas
#19
Marie-Claire Parriault, Astrid Van-Melle, Célia Basurko, Larissa Valmy, Bruno Hoen, André Cabié, Marie-Thérèse Goerger-Sow, Mathieu Nacher
The French overseas territories in the Americas are the French territories most affected by HIV. Crack cocaine users are particularly impacted. The objective of this study was to describe sexual risk behaviors and inconsistent condom use among crack cocaine users. A total of 640 crack cocaine users were interviewed. The sampling method was non-probabilistic. An anonymous standardized questionnaire of 110 questions was used. Over a third of persons did not use condoms systematically with casual sex partners (36...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28631387/umeclidinium-bromide-versus-placebo-for-people-with-chronic-obstructive-pulmonary-disease-copd
#20
REVIEW
Han Ni, Aung Htet, Soe Moe
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) have poor quality of life, reduced survival, and accelerated decline in lung function, especially associated with acute exacerbations, leading to high healthcare costs. Long-acting bronchodilators are the mainstay of treatment for symptomatic improvement, and umeclidinium is one of the new long-acting muscarinic antagonists approved for treatment of patients with stable COPD. OBJECTIVES: To assess the efficacy and safety of umeclidinium bromide versus placebo for people with stable COPD...
June 20, 2017: Cochrane Database of Systematic Reviews
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